                         SEQUENCE LISTING

<110>  The Research Foundation of State University of New York 
       SUNY at Stony Brook
       Wimmer, Eckard
       Cello, Jeronimo
       Liu, Ying
 
<120>  Novel Attenuated Poliovirus: PV-1 Mono-cre-X

<130>  14421/48976

<140>  not assigned
<141>  2012-12-13

<150>  US 61/576706
<151>  2011-12-16

<160>  3     

<170>  PatentIn version 3.5

<210>  1
<211>  7570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PV-1(mono-cre) attenuated  poliovirus


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  cloverleaf

<220>
<221>  misc_feature
<222>  (109)..(169)
<223>  PVcre(2C)

<220>
<221>  misc_feature
<222>  (4514)..(4574)
<223>  PVcre(2C) - inactivated

<400>  1
ttaaaacagc tctggggttg tacccacccc agaggcccac gtggcggcta gtactccggt       60

attgcggtac ccttgtacgc ctgttttata ctcccttccc gctagcacta ttaacaacta      120

catacagttc aagagcaaac accgtattga accagtatgt ttgctagtag ctagcttaga      180

cgcacaaaac caagttcaat agaagggggt acaaaccagt accaccacga acaagcactt      240

ctgtttcccc ggtgatgtcg tatagactgc ttgcgtggtt gaaagcgacg gatccgttat      300

ccgcttatgt acttcgagaa gcccagtacc acctcggaat cttcgatgcg ttgcgctcag      360

cactcaaccc cagagtgtag cttaggctga tgagtctgga catccctcac cggtgacggt      420

ggtccaggct gcgttggcgg cctacctatg gctaacgcca tgggacgcta gttgtgaaca      480

aggtgtgaag agcctattga gctacataag aatcctccgg cccctgaatg cggctaatcc      540

caacctcgga gcaggtggtc acaaaccagt gattggcctg tcgtaacgcg caagtccgtg      600

gcggaaccga ctactttggg tgtccgtgtt tccttttatt ttattgtggc tgcttatggt      660

gacaatcaca gattgttatc ataaagcgaa ttggattggc catccggtga aagtgagact      720

cattatctat ctgtttgctg gatccgctcc attgagtgtg tttactctaa gtacaatttc      780

aacagttatt tcaatcagac aattgtatca taatgggtgc tcaggtttca tcacagaaag      840

tgggcgcaca tgaaaactca aatagagcgt atggtagttc taccattaat tacaccacca      900

ttaattatta tagagattca gctagtaacg cggcttcgaa acaggacttc tctcaagacc      960

cttccaagtt caccgagccc atcaaggatg tcctgataaa aacagcccca atgctaaact     1020

cgccaaacat agaggcttgc gggtatagcg atagagtact gcaattaaca ctgggaaact     1080

ccactataac cacacaggag gcggctaatt cagtagtcgc ttatgggcgt tggcctgaat     1140

atctgaggga cagcgaagcc aatccagtgg accagccgac agaaccagac gtcgctgcat     1200

gcaggtttta tacgctagac accgtgtctt ggacgaaaga gtcgcgaggg tggtggtgga     1260

agttgcctga tgcactgagg gacatgggac tctttgggca aaatatgtac taccactacc     1320

taggtaggtc cgggtacacc gtgcatgtac agtgtaacgc ctccaaattc caccaggggg     1380

cactaggggt attcgccgta ccagagatgt gtctggccgg ggatagcaac accactacca     1440

tgcacaccag ctatcaaaat gccaatcctg gcgagaaagg aggcactttc acgggtacgt     1500

tcactcctga caacaaccag acatcacctg cccgcaggtt ctgcccggtg gattacctcc     1560

ttggaaatgg cacgttgttg gggaatgcct ttgtgttccc gcaccagata ataaacctac     1620

ggaccaacaa ctgtgctaca ctggtactcc cttacgtgaa ctccctctcg atagatagta     1680

tggtaaagca caataattgg ggaattgcaa tattaccatt ggccccatta aattttgcta     1740

gtgagtcctc cccagagatt ccaatcacct tgaccatagc ccctatgtgc tgtgagttca     1800

atggattaag aaacatcacc ctgccacgct tacagggcct gccggtcatg aacacccctg     1860

gtagcaatca atatcttact gcagacaact tccagtcacc gtgtgcgctg cctgaatttg     1920

atgtgacccc acctattgac atacccggtg aagtaaagaa catgatggaa ttggcagaaa     1980

tcgacaccat gattcccttt gacttaagtg ccacaaaaaa gaacaccatg gaaatgtata     2040

gggttcggtt aagtgacaaa ccacatacag acgatcccat actctgcctg tcactctctc     2100

cagcctcaga tcctaggttg tcacatacta tgcttggaga aatcctaaat tactacacac     2160

actgggcagg atccctgaag ttcacgtttc tgttctgtgg atccatgatg gcaactggca     2220

aactgttggt gtcatacgcg cctcctggag ccgacccacc aaagaagcgt aaggaggcga     2280

tgttgggaac acatgtgatc tgggacatag gactgcagtc ctcatgtact atggtagtgc     2340

catggattag caacaccacg tatcggcaaa ccatagatga tagtttcacc gaaggcggat     2400

acatcagcgt cttctaccaa actagaatag tcgtccctct ttcgacaccc agagagatgg     2460

acatccttgg ttttgtgtca gcgtgtaatg acttcagcgt gcgcttgttg cgagatacca     2520

cacatataga gcaaaaagcg ctagcacagg ggttaggtca gatgcttgaa agcatgattg     2580

acaacacagt ccgtgaaacg gtgggggcgg caacatctag agacgctctc ccaaacactg     2640

aagccagtgg accaacacac tccaaggaaa ttccggcact caccgcagtg gaaactgggg     2700

ccacaaatcc actagtccct tctgatacag tgcaaaccag acatgttgta caacataggt     2760

caaggtcaga gtctagcata gagtctttct tcgcgcgggg tgcatgcgtg accattatga     2820

ccgtggataa cccagcttcc accacgaata aggataagct ttttgcagtg tggaagatca     2880

cttataaaga tactgtccag ttacggagga aattggagtt cttcacctat tctagatttg     2940

atatggaact tacctttgtg gttactgcaa atttcactga gactaacaat ggccatgcat     3000

taaatcaagt gtaccaaatt atgtacgtac caccaggcgc tccagtgccc gaaaaatggg     3060

acgactacac atggcaaacc tcatcaaatc catcaatctt ttacacctac gggacagctc     3120

cagcccggat ctcggtaccg tatgttggta tttcgaacgc ctattcacac ttttacgacg     3180

gtttttccaa agtaccactg aaggaccagt cggcagcact aggtgactcc ctttatggtg     3240

cagcatctct aaatgacttc ggtattttgg ctgttagagt agtcaatgat cacaacccga     3300

ccaaggtcac ctccaaaatc agagtgtatc taaaacccaa acacatcaga gtctggtgcc     3360

cgcgtccacc gagggcagtg gcgtactacg gccctggagt ggattacaag gatggtacgc     3420

ttacacccct ctccaccaag gagctcacca catatggatt cggacaccaa aacaaagcgg     3480

tgtacactgc aggttacaaa atttgcaact accacttggc cactcaggat gatttgcaaa     3540

acgcagtgaa cgtcatgtgg agtagagacc tcttagtcac agaatcaaga gcccagggca     3600

ccgattcaat cgcaaggtgc aattgcaacg caggggtgta ctactgcgag tctagaagga     3660

aatactaccc agtatccttc gttggcccaa cgttccagta catggaggct aataactatt     3720

acccagctag gtaccagtcc catatgctca ttggccatgg attcgcatct ccaggggatt     3780

gtggtggcat actcagatgt caccacgggg tgatagggat cattactgct ggtggagaag     3840

ggttggttgc attttcagac attagagact tgtatgccta cgaagaagaa gccatggaac     3900

aaggcctcac caattacata gagtcacttg gggccgcatt tggaagtgga tttactcagc     3960

agattagcga caaaataaca gagttgacca atatggtgac cagtaccatc actgaaaagc     4020

tacttaagaa cttgatcaag atcatatcct cactagttat tataactagg aactatgaag     4080

acaccacaac agtgctcgct accctggccc ttcttgggtg tgatgcttca ccatggcagt     4140

ggcttagaaa gaaagcatgc gatgttctgg agatacctta tgtcatcaag caaggtgaca     4200

gttggttgaa gaagtttact gaagcatgca acgcagctaa gggactggag tgggtgtcaa     4260

acaaaatctc aaaattcatt gattggctca aggagaaaat tatcccacaa gctagagata     4320

agttggaatt tgtaacaaaa cttagacaac tagaaatgct ggaaaaccaa atctcaacta     4380

tacaccaatc atgccctagt caggaacacc aggaaattct attcaataat gtcagatggt     4440

tatccatcca gtctaagagg tttgcccctc tttacgcagt ggaagccaaa agaatacaga     4500

aactcgagca tactattaac aactacatac aatttaagag ccaacaccgt atcgaaccag     4560

tatgtttgct agtacatggc agccccggaa caggtaaatc tgtagcaacc aacctgattg     4620

ctagagccat agctgaaaga gaaaacacgt ccacgtactc gctacccccg gatccatcac     4680

acttcgacgg atacaaacaa cagggagtgg tgattatgga cgacctgaat caaaacccag     4740

atggtgcgga catgaagctg ttctgtcaga tggtatcaac agtggagttt ataccaccca     4800

tggcatccct ggaggagaaa ggaatcctgt ttacttcaaa ttacgttcta gcatccacaa     4860

actcaagcag aatttccccc cccactgtgg cacacagtga cgcgttagcc aggcgctttg     4920

cgttcgacat ggacattcag gtcatgaatg agtattctag agatgggaaa ttgaacatgg     4980

ccatggctac tgaaatgtgt aagaactgtc accaaccagc aaactttaag agatgctgtc     5040

ctttagtgtg tggtaaggca attcaattaa tggacaaatc ttccagagtt agatacagta     5100

ttgaccagat cactacaatg attatcaatg agagaaacag aagatccaac attggcaatt     5160

gtatggaggc tttgtttcaa ggaccactcc agtataaaga cttgaaaatt gacatcaaga     5220

cgagtccccc tcctgaatgt atcaatgact tgctccaagc agttgactcc caggaggtga     5280

gagattactg tgagaagaag ggttggatag ttaacatcac cagccaggtt caaacagaaa     5340

ggaacatcaa cagggcaatg acaattctac aagcggtgac aaccttcgcc gcagtggctg     5400

gagttgtcta tgtcatgtat aaactgtttg ctggacacca gggagcatac actggtttac     5460

caaacaaaaa acccaacgtg cccaccattc ggacagcaaa ggtacaagga ccagggttcg     5520

attacgcagt ggctatggct aaaagaaaca ttgttacagc aactactagc aagggagagt     5580

tcactatgtt aggagtccac gacaacgtgg ctattttacc aacccacgct tcacctggtg     5640

aaagcattgt gatcgatggc aaagaagtgg agatcttgga tgccaaagcg ctcgaagatc     5700

aagcaggaac caatcttgaa atcactataa tcactctaaa gagaaatgaa aagttcagag     5760

acattagacc acatatacct actcaaatca ctgagacaaa tgatggggtc ttgatcgtga     5820

acactagcaa gtaccccaat atgtatgttc ctgtcggtgc tgtgactgaa cagggatatc     5880

taaatctcgg tgggcgccaa actgctcgta ctctaatgta caactttcca accagagcag     5940

gacagtgtgg tggagtcatc acatgtactg ggaaagtcat cgggatgcat gttggtggga     6000

acggttcaca cgggtttgca gcggccctga agcgatcata cttcactcag agtcaaggtg     6060

aaatccagtg gatgagacct tcgaaggaag tgggatatcc aatcataaat gccccgtcca     6120

aaaccaagct tgaacccagt gctttccact atgtgtttga aggggtgaag gaaccagcag     6180

tcctcactaa aaacgatccc aggcttaaga cagactttga ggaggcaatt ttctccaagt     6240

acgtgggtaa caaaattact gaagtggatg agtacatgaa agaggcagta gaccactatg     6300

ctggccagct catgtcacta gacatcaaca tagaacaaat gtgcttggag gatgccatgt     6360

atggcactga tggtctagaa gcacttgatt tgtccaccag tgctggctac ccttatgtag     6420

caatgggaaa gaagaagaga gacatcttga acaaacaaac cagagacact aaggaaatgc     6480

aaaaactgct cgacacatat ggaatcaacc tcccactggt gacttatgta aaggatgaac     6540

ttagatccaa aacaaaggtt gagcagggga aatccagatt aattgaagct tctagtttga     6600

atgactcagt ggcaatgaga atggcttttg ggaacctata tgctgctttt cacaaaaacc     6660

caggagtgat aacaggttca gcagtggggt gcgatccaga tttgttttgg agcaaaattc     6720

cggtattgat ggaagagaag ctgtttgctt ttgactacac agggtatgat gcatctctca     6780

gccctgcttg gttcgaggca ctaaagatgg tgcttgagaa aatcggattc ggagacagag     6840

ttgactacat cgactaccta aaccactcac accacctgta caagaataaa acatactgtg     6900

tcaagggcgg tatgccatct ggctgctcag gcacttcaat ttttaactca atgattaaca     6960

acttgattat caggacactc ttactgaaaa cctacaaggg catagattta gaccacctaa     7020

aaatgattgc ctatggtgat gatgtaattg cttcctaccc ccatgaagtt gacgctagtc     7080

tcctagccca atcaggaaaa gactatggac taactatgac tccagctgac aaatcagcta     7140

catttgaaac agtcacatgg gagaatgtaa cattcttgaa gagattcttc agggcagacg     7200

agaaataccc atttcttatt catccagtaa tgccaatgaa ggaaattcat gaatcaatta     7260

gatggactaa agatcctagg aacactcagg atcacgttcg ctctctgtgc cttttagctt     7320

ggcacaatgg cgaagaagaa tataacaaat tcctagctaa aatcaggagt gtgccaattg     7380

gaagagcttt attgctccca gagtactcaa cattgtaccg ccgttggctt gactcatttt     7440

agtaacccta cctcagtcga attggattgg gtcatactgt tgtaggggta aatttttctt     7500

taattcggag gaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     7560

aaaaaaaaaa                                                            7570


<210>  2
<211>  2643
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  attenuated poliovirus

<400>  2
atgggagctc aggtgtcatc ccaaaaagta ggcgcacacg aaaactcgaa tcgggcatac       60

ggatctagta cgattaacta tactacaatc aattactata gggactccgc ctctaacgcc      120

gcttcgaaac aggacttttc gcaagaccct agcaagttta ccgaaccgat taaggacgtg      180

ttgatcaaaa ccgcacctat gcttaactca cctaacatag aggcatgcgg atactccgat      240

agggtgttgc aactgacact cggcaatagt acgattacga cacaggaagc cgctaatagc      300

gtagtcgcat acggaaggtg gcccgaatac cttagagact ccgaagcgaa tccagtcgat      360

cagcctaccg aacctgacgt cgccgcatgt cggttttaca cactcgatac cgtgtcatgg      420

actaaggaat cgcgagggtg gtggtggaaa ctgccagacg cattgcgcga tatggggttg      480

ttcggacaga atatgtacta tcactatctc ggaagatccg ggtataccgt acacgtgcaa      540

tgtaacgcct ctaagtttca ccagggagcg ttaggcgtat tcgcagtgcc agagatgtgt      600

ctagccggag actccaatac gactactatg catacctcat accaaaacgc taacccaggc      660

gaaaaggggg ggacatttac cggaacattc acacccgata acaatcagac atcccccgct      720

agacggtttt gcccagtcga ctatctactc ggaaacggta cactgttagg gaatgccttc      780

gtattcccac accagataat taacttacgg actaacaatt gcgcaaccct agtgttgcca      840

tacgttaact cactgtcaat cgatagtatg gtgaaacata acaattgggg gatcgcaata      900

ttaccgttag cgccactgaa tttcgccagc gaatcgtcac ctgagatacc gattaccctt      960

acaatcgcac ctatgtgttg cgagttcaac ggattgcgta atataaccct accacggttg     1020

caggggttgc ccgttatgaa taccccaggg tctaaccaat accttaccgc cgataatttc     1080

caatcccctt gcgcactgcc agagttcgac gtaacccctc caatcgacat acccggcgag     1140

gttaagaata tgatggagtt agccgaaatc gatactatga taccgttcga tctatccgct     1200

acgaaaaaga atactatgga gatgtatcgc gtgagattgt ccgataagcc acataccgac     1260

gatccgatac tgtgtctgtc actgtcaccc gccagcgatc ctaggttgtc ccatacaatg     1320

ttaggcgaga tactgaatta ctatacccat tgggccggta gtctgaaatt cacatttctg     1380

ttttgcggat ctatgatggc gaccggaaag ctgttagtgt catacgctcc acccggagcc     1440

gatccaccta aaaaacgcaa ggaagcgatg ctcggtacac acgtgatatg ggatatcgga     1500

ctgcaatcgt catgtactat ggtcgtgcca tggatatcga atacgactta tagacagaca     1560

atcgacgata gctttaccga gggggggtat attagcgtat tctatcagac acgtatcgta     1620

gtgccactgt caacccctag agagatggac atactcggat tcgtatccgc atgtaacgac     1680

tttagcgtga gactgttacg cgatactacc catatcgaac agaaagcgct agcacagggg     1740

ttagggcaaa tgctagagtc aatgatcgac aatactgtac gcgaaaccgt aggcgcagcg     1800

accagtaggg acgcactacc gaataccgaa gcgagcggac ctacccactc taaagagata     1860

ccggcactaa ccgccgtcga aaccggagcg actaacccac tagtcccatc cgataccgtg     1920

caaaccagac acgtagtgca acatcggtct agatccgagt catcaatcga atcctttttc     1980

gctagaggcg catgcgttac gattatgacc gtcgataacc cagcgtcaac gactaacaaa     2040

gacaaattgt tcgccgtatg gaaaattacc tataaggata ccgtgcaatt gcgacgtaaa     2100

ctagagttct ttacatactc tagattcgat atggagctta cattcgtagt gaccgctaac     2160

tttaccgaga ctaataacgg tcacgccctt aatcaggtgt atcagattat gtacgtaccg     2220

ccaggcgcac cagtgcccga aaaatgggac gactatacat ggcagactag ctctaatccg     2280

tcaattttct atacatacgg taccgcacca gctaggatta gcgtgccata cgtcggtata     2340

tcgaacgctt actcacactt ttacgacgga ttctctaaag tgccacttaa ggaccaatcc     2400

gccgcactag gcgatagcct atacggagcc gctagtctta acgatttcgg tatactcgcc     2460

gttagggtcg tgaacgacca taaccctact aaggtcacct ctaagattag ggtgtatctt     2520

aagcctaagc atattagggt gtggtgtcct agaccgccta gagccgttgc gtattacgga     2580

ccaggcgtcg actataagga cggtacattg accccactgt caacgaaaga ccttacgacg     2640

tac                                                                   2643


<210>  3
<211>  7579
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PV-1(mono-cre-X) attenuated poliovirus


<220>
<221>  misc_feature
<222>  (1)..(88)
<223>  cloverleaf

<220>
<221>  misc_feature
<222>  (109)..(169)
<223>  PVcre(2C)

<220>
<221>  misc_feature
<222>  (4503)..(4563)
<223>  PVcre(2C)inactivated

<400>  3
ttaaaacagc tctggggttg tacccacccc agaggcccac gtggcggcta gtactccggt       60

attgcggtac ccttgtacgc ctgttttata ctcccttccc gctagcacta ttaacaacta      120

catacagttc aagagcaaac accgtattga accagtatgt ttgctagtag ctagcttaga      180

cgcacaaaac caagttcaat agaagggggt acaaaccagt accaccacga acaagcactt      240

ctgtttcccc ggtgatgtcg tatagactgc ttgcgtggtt gaaagcgacg gatccgttat      300

ccgcttatgt acttcgagaa gcccagtacc acctcggaat cttcgatgcg ttgcgctcag      360

cactcaaccc cagagtgtag cttaggctga tgagtctgga catccctcac cggtgacggt      420

ggtccaggct gcgttggcgg cctacctatg gctaacgcca tgggacgcta gttgtgaaca      480

aggtgtgaag agcctattga gctacataag aatcctccgg cccctgaatg cggctaatcc      540

caacctcgga gcaggtggtc acaaaccagt gattggcctg tcgtaacgcg caagtccgtg      600

gcggaaccga ctactttggg tgtccgtgtt tccttttatt ttattgtggc tgcttatggt      660

gacaatcaca gattgttatc ataaagcgaa ttggattggc catccggtga aagtgagact      720

cattatctat ctgtttgctg gatccgctcc attgagtgtg tttactctaa gtacaatttc      780

aacagttatt tcaatcagac aattgtatca taatgggagc tcaggtgtca tcccaaaaag      840

taggcgcaca cgaaaactcg aatcgggcat acggatctag tacgattaac tatactacaa      900

tcaattacta tagggactcc gcctctaacg ccgcttcgaa acaggacttt tcgcaagacc      960

ctagcaagtt taccgaaccg attaaggacg tgttgatcaa aaccgcacct atgcttaact     1020

cacctaacat agaggcatgc ggatactccg atagggtgtt gcaactgaca ctcggcaata     1080

gtacgattac gacacaggaa gccgctaata gcgtagtcgc atacggaagg tggcccgaat     1140

accttagaga ctccgaagcg aatccagtcg atcagcctac cgaacctgac gtcgccgcat     1200

gtcggtttta cacactcgat accgtgtcat ggactaagga atcgcgaggg tggtggtgga     1260

aactgccaga cgcattgcgc gatatggggt tgttcggaca gaatatgtac tatcactatc     1320

tcggaagatc cgggtatacc gtacacgtgc aatgtaacgc ctctaagttt caccagggag     1380

cgttaggcgt attcgcagtg ccagagatgt gtctagccgg agactccaat acgactacta     1440

tgcatacctc ataccaaaac gctaacccag gcgaaaaggg ggggacattt accggaacat     1500

tcacacccga taacaatcag acatcccccg ctagacggtt ttgcccagtc gactatctac     1560

tcggaaacgg tacactgtta gggaatgcct ttgtgttccc gcaccagata ataaacctac     1620

ggaccaacaa ctgtgctaca ctggtactcc cttacgtgaa ctccctctcg atagatagta     1680

tggtaaagca caataattgg ggaattgcaa tattaccatt ggccccatta aattttgcta     1740

gtgagtcctc cccagagatt ccaatcacct tgaccatagc ccctatgtgc tgtgagttca     1800

atggattaag aaacatcacc ctgccacgct tacagggcct gccggtcatg aacacccctg     1860

gtagcaatca atatcttact gcagacaact tccagtcacc gtgtgcgctg cctgaatttg     1920

atgtgacccc acctattgac atacccggtg atgatggaat tggcagaaat cgacaccatg     1980

attccctttg acttaagtgc cacaaaaaag aacaccatgg aaatgtatag ggttcggtta     2040

agtgacaaac cacatacaga cgatcccata ctctgcctgt cactctctcc agcctcagat     2100

cctaggttgt cacatactat gcttggagaa atcctaaatt actacacaca ctgggcagga     2160

tccctgaagt tcacgtttct gttctgtgga tccatgatgg caactggcaa actgttggtg     2220

tcatacgcgc ctcctggagc cgacccacca aagaagcgta aggaggcgat gttgggaaca     2280

catgtgatct gggacatagg actgcagtcc tcatgtacta tggtagtgcc atggattagc     2340

aacaccacgt atcggcaaac catagatgat agtttcaccg aaggcggata catcagcgtc     2400

ttctaccaaa ctagaatagt cgtccctctt tcgacaccca gagagatgga catccttggt     2460

tttgtgtcag cgtgtaatga cttcagcgtg cgcttgttgc gagataccac acatatagag     2520

caaaaagcgc tagcacaggg gttaggtcag atgcttgaaa gcatgattga caacacagtc     2580

cgtgaaacgg tgggggcggc aacatctaga gacgctctcc caaacactga agccagtgga     2640

ccaacacact ccaaggaaat tccggcactc accgcagtgg aaactggggc cacaaatcca     2700

ctagtccctt ctgatacagt gcaaaccaga catgttgtac aacataggtc aaggtcagag     2760

tctagcatag agtctttctt cgcgcggggt gcatgcgtga ccattatgac cgtggataac     2820

ccagcttcca ccacgaataa ggataagctt tttgcagtgt ggaagatcac ttataaagat     2880

actgtccagt tacggaggaa attggagttc ttcacctatt ctagatttga tatggaactt     2940

acctttgtgg ttactgcaaa tttcactgag actaacaatg gccatgcatt aaatcaagtg     3000

taccaaatta tgtacgtacc accaggcgct ccagtgcccg aaaaatggga cgactacaca     3060

tggcaaacct catcaaatcc atcaatcttt tacacctacg ggacagctcc agcccggatc     3120

tcggtaccgt atgttggtat ttcgaacgcc tattcacact tttacgacgg tttttccaaa     3180

gtaccactga aggaccagtc ggcagcacta ggtgactccc tttatggtgc agcatctcta     3240

aatgacttcg gtattttggc tgttagagta gtcaatgatc acaacccgac caaggtcacc     3300

tccaaaatca gagtgtatct aaaacccaaa cacatcagag tctggtgccc gcgtccaccg     3360

agggcagtgg cgtactacgg ccctggagtg gattacaagg atggtacgct tacacccctc     3420

tccaccaagg atctgaccac atatggattc ggacaccaaa acaaagcggt gtacactgca     3480

ggttacaaaa tttgcaacta ccacttggcc actcaggatg atttgcaaaa cgcagtgaac     3540

gtcatgtgga gtagagacct cttagtcaca gaatcaagag cccagggcac cgattcaatc     3600

gcaaggtgca attgcaacgc aggggtgtac tactgcgagt ctagaaggaa atactaccca     3660

gtatccttcg ttggcccaac gttccagtac atggaggcta ataactatta cccagctagg     3720

taccagtccc atatgctcat tggccatgga ttcgcatctc caggggattg tggtggcata     3780

ctcagatgtc accacggggt gatagggatc attactgctg gtggagaagg gttggttgca     3840

ttttcagaca ttagagactt gtatgcctac gaagaagaag ccatggaaca aggcctcacc     3900

aattacatag agtcacttgg ggccgcattt ggaagtggat ttactcagca gattagcgac     3960

aaaataacag agttgaccaa tatggtgacc agtaccatca ctgaaaagct acttaagaac     4020

ttgatcaaga tcatatcctc actagttatt ataactagga actatgaaga caccacaaca     4080

gtgctcgcta ccctggccct tcttgggtgt gatgcttcac catggcagtg gcttagaaag     4140

aaagcatgcg atgttctgga gataccttat gtcatcaagc aaggtgacag ttggttgaag     4200

aagtttactg aagcatgcaa cgcagctaag ggcctggagt gggtgtcaaa caaaatctca     4260

aaattcattg attggctcaa ggagaaaatt atcccacaag ctagagataa gttggaattt     4320

gtaacaaaac ttagacaact agaaatgctg gaaaaccaaa tctcaactat acaccaatca     4380

tgccctagtc aggaacacca ggaaattcta ttcaataatg tcagatggtt atccatccag     4440

tctaagaggt ttgcccctct ttacgcagtg gaagccaaaa gaatacagaa actcgagcat     4500

actattaaca actacataca atttaagagc caacaccgta tcgaaccagt atgtttgcta     4560

gtacatggca gccccggaac aggtaaatct gtagcaacca acctgattgc tagagccata     4620

gctgaaagag aaaacacgtc cacgtactcg ctacccccgg atccatcaca cttcgacgga     4680

tacaaacaac agggagtggt gattatggac gacctgaatc aaaacccaga tggtgcggac     4740

atgaagctgt tctgtcagat ggtatcaaca gtggagttta taccacccat ggcatccctg     4800

gaggagaaag gaatcctgtt tacttcaaat tacgttctag catccacaaa ctcaagcaga     4860

atttcccccc ccactgtggc acacagtgac gcgttagcca ggcgctttgc gttcgacatg     4920

gacattcagg tcatgaatga gtattctaga gatgggaaat tgaacatggc catggctact     4980

gaaatgtgta agaactgtca ccaaccagca aactttaaga gatgctgtcc tttagtgtgt     5040

ggtaaggcaa ttcaattaat ggacaaatct tccagagtta gatacagtat tgaccagatc     5100

actacaatga ttatcaatga gagaaacaga agatccaaca ttggcaattg tatggaggct     5160

ttgtttcaag gaccactcca gtataaagac ttgaaaattg acatcaagac gagtccccct     5220

cctgaatgta tcaatgactt gctccaagca gttgactccc aggaggtgag agattactgt     5280

gagaagaagg gttggatagt taacatcacc agccaggttc aaacagaaag gaacatcaac     5340

agggcaatga caattctaca agcggtgaca accttcgccg cagtggctgg agttgtctat     5400

gtcatgtata aactgtttgc tggacaccag ggagcataca ctggtttacc aaacaaaaaa     5460

cccaacgtgc ccaccattcg gacagcaaag gtacaaggac cagggttcga ttacgcagtg     5520

gctatggcta aaagaaacat tgttacagca actactagca agggagagtt cactatgtta     5580

ggagtccacg acaacgtggc tattttacca acccacgctt cacctggtga aagcattgtg     5640

atcgatggca aagaagtgga gatcttggat gccaaagcgc tcgaagatca agcaggaacc     5700

aatcttgaaa tcactataat cactctaaag agaaatgaaa agttcagaga cattagacca     5760

catataccta ctcaaatcac tgagacaaat gatggagtct tgatcgtgaa cactagcaag     5820

taccccaata tgtatgttcc tgtcggtgct gtgactgaac agggatatct aaatctcggt     5880

gggcgccaaa ctgctcgtac tctaatgtac aactttccaa ccagagcagg acagtgtggt     5940

ggagtcatca catgtactgg gaaagtcatc gggatgcatg ttggtgggaa cggttcacac     6000

gggtttgcag cggccctgaa gcgatcatac ttcactcaga gtcaaggtga aatccagtgg     6060

atgagacctt cgaaggaagt gggatatcca atcataaatg ccccgtccaa aaccaagctt     6120

gaacccagtg ctttccacta tgtgtttgaa ggggtgaagg aaccagcagt cctcactaaa     6180

aacgatccca ggcttaagac agactttgag gaggcaattt tctccaagta cgtgggtaac     6240

aaaattactg aagtggatga gtacatgaaa gaggcagtag accactatgc tggccagctc     6300

atgtcactag acatcaacac agaacaaatg tgcttggagg atgccatgta tggcactgat     6360

ggtctagaag cacttgattt gtccaccagt gctggctacc cttatgtagc aatgggaaag     6420

aagaagagag acatcttgaa caaacaaacc agagacacta aggaaatgca aaaactgctc     6480

gacacatatg gaatcaacct cccactggtg acttatgtaa aggatgaact tagatccaaa     6540

acaaaggttg agcaggggaa atccagatta attgaagctt ctagtttgaa tgactcagtg     6600

gcaatgagaa tggcttttgg gaacctatat gctgcttttc acaaaaaccc aggagtgata     6660

acaggttcag cagtggggtg cgatccagat ttgttttgga gcaaaattcc ggtattgatg     6720

gaagagaagc tgtttgcttt tgactacaca gggtatgatg catctctcag ccctgcttgg     6780

ttcgaggcac taaagatggt gcttgagaaa atcggattcg gagacagagt tgactacatc     6840

gactacctaa accactcaca ccacctgtac aagaataaaa catactgtgt caagggcggt     6900

atgccatctg gctgctcagg cacttcaatt tttaactcaa tgattaacaa cttgattatc     6960

aggacactct tactgaaaac ctacaagggc atagatttag accacctaaa aatgattgcc     7020

tatggtgatg atgtaattgc ttcctacccc catgaagttg acgctagtct cctagcccaa     7080

tcaggaaaag actatggact aactatgact ccagctgaca aatcagctac atttgaaaca     7140

gtcacatggg agaatgtaac attcttgaag agattcttca gggcagacga gaaataccca     7200

tttcttattc atccagtaat gccaatgaag gaaattcatg aatcaattag atggactaaa     7260

gatcctagga acactcagga tcacgttcgc tctctgtgcc ttttagcttg gcacaatggc     7320

gaagaagaat ataacaaatt cctagctaaa atcaggagtg tgccaattgg aagagcttta     7380

ttgctcccag agtactcaac attgtaccgc cgttggcttg actcatttta gtaaccctac     7440

ctcagtcgaa ttggattggg tcatactgtt gtaggggtaa atttttcttt aattcggaga     7500

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     7560

aaaaaaaaaa aaaaaaaaa                                                  7579


