                               SEQUENCE LISTING

<110> TRUSTEES OF BOSTON UNIVERSITY
 
<120> UTILITY OF INSULIN-LIKE 6 (INSL6) FOR THE TREATMENT OF 
      AUTOIMMUNE DISEASES

<130> 701586-072631-PCT

<140>
<141>

<150> 61/569,499
<151> 2011-12-12

<160> 4     

<170> PatentIn version 3.5

<210> 1
<211> 213
<212> PRT
<213> Homo sapiens

<400> 1
Met Pro Arg Leu Leu Arg Leu Ser Leu Leu Trp Leu Gly Leu Leu Leu 
1               5                   10                  15      


Val Arg Phe Ser Arg Glu Leu Ser Asp Ile Ser Ser Ala Arg Lys Leu 
            20                  25                  30          


Cys Gly Arg Tyr Leu Val Lys Glu Ile Glu Lys Leu Cys Gly His Ala 
        35                  40                  45              


Asn Trp Ser Gln Phe Arg Phe Glu Glu Glu Thr Pro Phe Ser Arg Leu 
    50                  55                  60                  


Ile Ala Gln Ala Ser Glu Lys Val Glu Ala Tyr Ser Pro Tyr Gln Phe 
65                  70                  75                  80  


Glu Ser Pro Gln Thr Ala Ser Pro Ala Arg Gly Arg Gly Thr Asn Pro 
                85                  90                  95      


Val Ser Thr Ser Trp Glu Glu Ala Val Asn Ser Trp Glu Met Gln Ser 
            100                 105                 110         


Leu Pro Glu Tyr Lys Asp Lys Lys Gly Tyr Ser Pro Leu Gly Lys Thr 
        115                 120                 125             


Arg Glu Phe Ser Ser Ser His Asn Ile Asn Val Tyr Ile His Glu Asn 
    130                 135                 140                 


Ala Lys Phe Gln Lys Lys Arg Arg Asn Lys Ile Lys Thr Leu Ser Asn 
145                 150                 155                 160 


Leu Phe Trp Gly His His Pro Gln Arg Lys Arg Arg Gly Tyr Ser Glu 
                165                 170                 175     


Lys Cys Cys Leu Thr Gly Cys Thr Lys Glu Glu Leu Ser Ile Ala Cys 
            180                 185                 190         


Leu Pro Tyr Ile Asp Phe Lys Arg Leu Lys Glu Lys Arg Ser Ser Leu 
        195                 200                 205             


Val Thr Lys Ile Tyr 
    210             


<210> 2
<211> 711
<212> DNA
<213> Homo sapiens

<400> 2
gcctggggtc acagggatgc cgcggctcct ccgcttgtcc ctgctgtggc ttggactcct       60

gctggttcgg ttttctcgtg aactgagcga catcagcagt gccaggaagc tgtgcggcag      120

gtacttggtg aaagaaatag aaaaactctg cggccatgcc aactggagcc agttccgttt      180

cgaggaggaa acccctttct cacggttgat tgcacaggcc tcggagaagg tcgaagccta      240

cagcccatac cagttcgaaa gcccgcaaac cgcttccccg gcccggggaa gaggcacaaa      300

cccagtgtct acttcttggg aagaagcagt aaacagttgg gaaatgcagt cactacctga      360

gtataaggat aaaaagggat attcacccct tggtaagaca agagaatttt cttcatcaca      420

taatatcaat gtatatattc atgagaatgc aaaatttcag aagaaacgta gaaacaaaat      480

taaaacctta agcaatttgt tttgggggca tcatccccaa agaaaacgca gaggatattc      540

agaaaagtgt tgtcttacag gatgtacaaa agaagaactt agcattgcat gtcttccata      600

tattgatttt aaaaggctaa aggaaaaaag atcatcactt gtaactaaga tatactaacc      660

atcttagaat tttttctaac ctaataaaag cttaatacat ttatttaaaa a               711


<210> 3
<211> 252
<212> PRT
<213> Homo sapiens

<400> 3
Leu Glu Leu Val Pro Arg Gly Ser Gly Asp Pro Ile Glu Gly Arg Gly 
1               5                   10                  15      


Gly Gly Gly Gly Asp Pro Lys Ser Cys Asp Lys Pro His Thr Cys Pro 
            20                  25                  30          


Leu Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Ala Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      6xHis tag

<400> 4
His His His His His His 
1               5       


