﻿SEQUENCE LISTING

<110>   Novartis AG

<120>   Method of detecting the presence of an antibody in a sample

<130>   P058614WO

<141>   2012-12-12

<150>   GB1121301.4
<151>   2011-12-12

<160>   36

<170>   SeqWin2010, version 1.0

<210>   1
<211>   436
<212>   DNA
<213>   Mus musculus

<400>   1
catgaagttg cctgttaggc tgttggtgct gatgttctgg attcctgttt ccagcagtga  60
tgctgtgatg acccaaactc cactctccct gcctgtcagt cttggagatc aagcctccat  120
ctcctgcagg tctagtcaga gccttgaaaa cactgatgga agcacctatt tgaactggta  180
cctccagaaa ccaggccagt ctccacagct cctgatctac agggtttcca cccgattttc  240
tggggtccta gacaggttca gtggtagtgg atcagggaca gatttcacac tgaaaatcag  300
cagagtggag gctgaggatt tgggagttta tttctgcctc caacttacac atgtcccgta  360
cacgttcgga ggggggacca agctggaaat aaaacgggct gatgctgcac caactgtatc  420
catcttccca ccatcc                                                  436

<210>   2
<211>   146
<212>   PRT
<213>   Mus musculus

<400>   2
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Val 
1               5                   10                  15      

Ser Ser Ser Asp Ala Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          

Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              

Glu Asn Thr Asp Gly Ser Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  

Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser 
65                  70                  75                  80  

Gly Val Leu Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         

Leu Gln Leu Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 

Ser Ser 
145     

<210>   3
<211>   436
<212>   DNA
<213>   Mus musculus

<400>   3
atggctgtct tagggctgtt cttctgcctg gtgacattcc caagctgtgt cctatcccag  60
gtgcagctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc  120
tgcacagtct ctggtttctc attaactagc tatggtgtac actgggttcg ccagtctcca  180
ggaaagggtc tggagtggct gggagtgata tggaatggtg gaagcacaga ctataatgca  240
gctttcatat ccagactaaa catcatcaag gacaattcca agagccaagt tttctttaag  300
atgaacaatc ttcaagctga tgacacagcc acatattact gtgtcagaaa ctgggactac  360
tggggccaag gcaccactct cacagtctcc tcagctacaa caacagcccc atctgtctat  420
cccctggccc ctggaa                                                  436

<210>   4
<211>   145
<212>   PRT
<213>   Mus musculus

<400>   4
Met Ala Val Leu Gly Leu Phe Phe Cys Leu Val Thr Phe Pro Ser Cys 
1               5                   10                  15      

Val Leu Ser Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln 
            20                  25                  30          

Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu 
        35                  40                  45              

Thr Ser Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu 
    50                  55                  60                  

Glu Trp Leu Gly Val Ile Trp Asn Gly Gly Ser Thr Asp Tyr Asn Ala 
65                  70                  75                  80  

Ala Phe Ile Ser Arg Leu Asn Ile Ile Lys Asp Asn Ser Lys Ser Gln 
                85                  90                  95      

Val Phe Phe Lys Met Asn Asn Leu Gln Ala Asp Asp Thr Ala Thr Tyr 
            100                 105                 110         

Tyr Cys Val Arg Asn Trp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             

Val Ser Ser Ala Thr Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 

Gly 
145 

<210>   5
<211>   449
<212>   DNA
<213>   Mus musculus

<400>   5
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat  60
gttttgatga cccaatctcc actctccctg cctgtcagtc ttggagatca agcctccatc  120
tcttgcagat ctagtcagat cattgtacat agtaatggaa acacctattt agagtggtac  180
ctgcagaaac caggccagtc tccaaagctc ctgatctaca gagtttccaa ccgattttct  240
ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc  300
agagtggagg ctgaggatct gggagtttat tactgctttc aaggttcaca tgttccgtac  360
acgttcggag gggggaccaa gctggaaata aaacgggctg atgctgcacc aactgtatcc  420
atcttcccac catccagtaa agcttggga                                    449

<210>   6
<211>   149
<212>   PRT
<213>   Mus musculus

<400>   6
Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      

Ser Ser Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 
            20                  25                  30          

Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile 
        35                  40                  45              

Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 
    50                  55                  60                  

Gly Gln Ser Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  

Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         

Phe Gln Gly Ser His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             

Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 
    130                 135                 140                 

Ser Ser Lys Ala Trp 
145                 

<210>   7
<211>   464
<212>   DNA
<213>   Mus musculus

<400>   7
catgggcagg cttacttttt cattcttgct actgattgtc cctgcatatg tcctgtgcca  60
ggttactctg aaagagtctg gcccggggat attgcagccc tcccagaccc tcagtctgac  120
ttgttctttc tctgggtttt cactgagcac ttctaatatg ggtgtaggct ggattcgtca  180
gccttcaggg aagggtctgg agtggctctt acacattttg tggaatgata gtaagtacta  240
taatccagcc ctgaagagcc ggctcacaat ctccaaggat acctacaaca acaaggtatt  300
cctcaagatc gccaatgtgg acactgcaga ttctgccaca tactactgtg ttcgattccc  360
ccatgatggt tacaaagtta tggactactg gggtcaagga acctcagtca ccgtctcctc  420
agccaaaacg acacccccat ctgtctatcc cctggcccct ggaa                   464

<210>   8
<211>   154
<212>   PRT
<213>   Mus musculus

<400>   8
Met Gly Arg Leu Thr Phe Ser Phe Leu Leu Leu Ile Val Pro Ala Tyr 
1               5                   10                  15      

Val Leu Cys Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln 
            20                  25                  30          

Pro Ser Gln Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu 
        35                  40                  45              

Ser Thr Ser Asn Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys 
    50                  55                  60                  

Gly Leu Glu Trp Leu Leu His Ile Leu Trp Asn Asp Ser Lys Tyr Tyr 
65                  70                  75                  80  

Asn Pro Ala Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Tyr Asn 
                85                  90                  95      

Asn Lys Val Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ser Ala 
            100                 105                 110         

Thr Tyr Tyr Cys Val Arg Phe Pro His Asp Gly Tyr Lys Val Met Asp 
        115                 120                 125             

Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Lys Thr Thr 
    130                 135                 140                 

Pro Pro Ser Val Tyr Pro Leu Ala Pro Gly 
145                 150                 

<210>   9
<211>   477
<212>   DNA
<213>   Mus musculus

<400>   9
tactagtcga catgggcttc aagatgaagt cacagtccca ggttcttatg ttactgctgc  60
tatgggtatc tggtacctgt ggggacattg tgatgtcaca gtctccatcc tccctaactg  120
tgtcagttgg agagaaggtt actatgagct gcaagtccag tcagagcctt ttatatagta  180
gcaatcaaaa gaactacttg gcctggtacc agcagaaacc agggcagtct cctaaactgc  240
tgatttactg ggcatccact agggattctg gggtccctga tcgcttcaca ggcagtggat  300
ctgggacaga tttcactctc accatcagca gtgtgaaggc tgaagacctg gcagtttatt  360
actgtcagca atattatagc tatccgtaca cgttcggagg ggggaccaag ctggaaataa  420
aacgggctga tgctgcacca actgtatcca tcttcccacc atccagtaag cttggga     477

<210>   10
<211>   158
<212>   PRT
<213>   Mus musculus

<400>   10
Leu Val Asp Met Gly Phe Lys Met Lys Ser Gln Ser Gln Val Leu Met 
1               5                   10                  15      

Leu Leu Leu Leu Trp Val Ser Gly Thr Cys Gly Asp Ile Val Met Ser 
            20                  25                  30          

Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly Glu Lys Val Thr Met 
        35                  40                  45              

Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn 
    50                  55                  60                  

Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu 
65                  70                  75                  80  

Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val Pro Asp Arg Phe Thr 
                85                  90                  95      

Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Lys 
            100                 105                 110         

Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro 
        115                 120                 125             

Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
    130                 135                 140                 

Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Lys Leu Gly 
145                 150                 155             

<210>   11
<211>   444
<212>   DNA
<213>   Mus musculus

<400>   11
cttgattttc cttgccctca ttttaaaagg tgtccagtgt gaggtgcagc tggtggagtc  60
tgggggagac ttagtgaagc ctggagggtc cctgaaactc tcctgtgcag cctctggatt  120
cactttcagt agctctggca tgtcttgggt tcgccagact ccagacaaga ggctggagtg  180
ggtcgcaatt gttactagtg gtggtagtta cacctactgt ccagacagtg tgaaggggcg  240
attcaccatc tccagagaca atgccaagca caccctgtac ctgcaaatga gcagtccgaa  300
gtctgaggac acagccatgt tttactgtgc aagacatggg gtctactata ggtttgacta  360
ctggggccaa ggcaccactc tcacagtctc ctcagccaaa acaacacccc catcagtcta  420
tcccctggcc cctggaagct tggg                                         444

<210>   12
<211>   147
<212>   PRT
<213>   Mus musculus

<400>   12
Leu Ile Phe Leu Ala Leu Ile Leu Lys Gly Val Gln Cys Glu Val Gln 
1               5                   10                  15      

Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser Leu Lys 
            20                  25                  30          

Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Gly Met Ser 
        35                  40                  45              

Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala Ile Val 
    50                  55                  60                  

Thr Ser Gly Gly Ser Tyr Thr Tyr Cys Pro Asp Ser Val Lys Gly Arg 
65                  70                  75                  80  

Phe Thr Ile Ser Arg Asp Asn Ala Lys His Thr Leu Tyr Leu Gln Met 
                85                  90                  95      

Ser Ser Pro Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys Ala Arg His 
            100                 105                 110         

Gly Val Tyr Tyr Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
        115                 120                 125             

Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
    130                 135                 140                 

Gly Ser Leu 
145         

<210>   13
<211>   112
<212>   PRT
<213>   Mus musculus

<400>   13
Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly Asp Gln 
1               5                   10                  15      

Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Glu Asn Thr Asp Gly 
            20                  25                  30          

Ser Thr Tyr Leu Asn Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 
        35                  40                  45              

Leu Leu Ile Tyr Arg Val Ser Thr Arg Phe Ser Gly Val Leu Asp Arg 
    50                  55                  60                  

Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 
65                  70                  75                  80  

Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Leu Gln Leu Thr His 
                85                  90                  95      

Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 110         

<210>   14
<211>   112
<212>   PRT
<213>   Mus musculus

<400>   14
Gln Val Gln Leu Lys Gln Ser Gly Pro Gly Leu Val Gln Pro Ser Gln 
1               5                   10                  15      

Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          

Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              

Gly Val Ile Trp Asn Gly Gly Ser Thr Asp Tyr Asn Ala Ala Phe Ile 
    50                  55                  60                  

Ser Arg Leu Asn Ile Ile Lys Asp Asn Ser Lys Ser Gln Val Phe Phe 
65                  70                  75                  80  

Lys Met Asn Asn Leu Gln Ala Asp Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      

Arg Asn Trp Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 
            100                 105                 110         

<210>   15
<211>   113
<212>   PRT
<213>   Mus musculus

<400>   15
Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Ser Leu Gly Asp 
1               5                   10                  15      

Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ile Ile Val His Ser Asn 
            20                  25                  30          

Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Arg Val Ser Asn Arg Phe Ser Gly Val Pro Asp 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser 
65                  70                  75                  80  

Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln Gly Ser 
                85                  90                  95      

His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

Ala 
    

<210>   16
<211>   121
<212>   PRT
<213>   Mus musculus

<400>   16
Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      

Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          

Asn Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              

Trp Leu Leu His Ile Leu Trp Asn Asp Ser Lys Tyr Tyr Asn Pro Ala 
    50                  55                  60                  

Leu Lys Ser Arg Leu Thr Ile Ser Lys Asp Thr Tyr Asn Asn Lys Val 
65                  70                  75                  80  

Phe Leu Lys Ile Ala Asn Val Asp Thr Ala Asp Ser Ala Thr Tyr Tyr 
                85                  90                  95      

Cys Val Arg Phe Pro His Asp Gly Tyr Lys Val Met Asp Tyr Trp Gly 
            100                 105                 110         

Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120     

<210>   17
<211>   113
<212>   PRT
<213>   Mus musculus

<400>   17
Val Met Ser Gln Ser Pro Ser Ser Leu Thr Val Ser Val Gly Glu Lys 
1               5                   10                  15      

Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn 
            20                  25                  30          

Gln Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Asp Ser Gly Val Pro Asp 
    50                  55                  60                  

Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  

Ser Val Lys Ala Glu Asp Leu Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr 
                85                  90                  95      

Ser Tyr Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

Ala 
    

<210>   18
<211>   117
<212>   PRT
<213>   Mus musculus

<400>   18
Val Gln Leu Val Glu Ser Gly Gly Asp Leu Val Lys Pro Gly Gly Ser 
1               5                   10                  15      

Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser Gly 
            20                  25                  30          

Met Ser Trp Val Arg Gln Thr Pro Asp Lys Arg Leu Glu Trp Val Ala 
        35                  40                  45              

Ile Val Thr Ser Gly Gly Ser Tyr Thr Tyr Cys Pro Asp Ser Val Lys 
    50                  55                  60                  

Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys His Thr Leu Tyr Leu 
65                  70                  75                  80  

Gln Met Ser Ser Pro Lys Ser Glu Asp Thr Ala Met Phe Tyr Cys Ala 
                85                  90                  95      

Arg His Gly Val Tyr Tyr Arg Phe Asp Tyr Trp Gly Gln Gly Thr Thr 
            100                 105                 110         

Leu Thr Val Ser Ser 
        115         

<210>   19
<211>   17
<212>   PRT
<213>   Mus musculus

<400>   19
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Gln Lys Asn Tyr Leu 
1               5                   10                  15      

Ala 
    

<210>   20
<211>   7
<212>   PRT
<213>   Mus musculus

<400>   20
Trp Ala Ser Thr Arg Asp Ser 
1               5           

<210>   21
<211>   9
<212>   PRT
<213>   Mus musculus

<400>   21
Gln Gln Tyr Tyr Ser Tyr Pro Tyr Thr 
1               5                   

<210>   22
<211>   10
<212>   PRT
<213>   Mus musculus

<400>   22
Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  

<210>   23
<211>   9
<212>   PRT
<213>   Mus musculus

<400>   23
Val Ile Trp Asn Gly Gly Ser Thr Asp 
1               5                   

<210>   24
<211>   4
<212>   PRT
<213>   Mus musculus

<400>   24
Asn Trp Asp Tyr 
1               

<210>   25
<211>   16
<212>   PRT
<213>   Mus musculus

<400>   25
Arg Ser Ser Gln Ile Ile Val His Ser Asn Gly Asn Thr Tyr Leu Glu 
1               5                   10                  15      

<210>   26
<211>   7
<212>   PRT
<213>   Mus musculus

<400>   26
Arg Val Ser Asn Arg Phe Ser 
1               5           

<210>   27
<211>   9
<212>   PRT
<213>   Mus musculus

<400>   27
Phe Gln Gly Ser His Val Pro Tyr Thr 
1               5                   

<210>   28
<211>   12
<212>   PRT
<213>   Mus musculus

<400>   28
Gly Phe Ser Leu Ser Thr Ser Asn Met Gly Val Gly 
1               5                   10          

<210>   29
<211>   9
<212>   PRT
<213>   Mus musculus

<400>   29
His Ile Leu Trp Asn Asp Ser Lys Tyr 
1               5                   

<210>   30
<211>   11
<212>   PRT
<213>   Mus musculus

<400>   30
Phe Pro His Asp Gly Tyr Lys Val Met Asp Tyr 
1               5                   10      

<210>   31
<211>   16
<212>   PRT
<213>   Mus musculus

<400>   31
Arg Ser Ser Gln Ser Leu Glu Asn Thr Asp Gly Ser Thr Tyr Leu Asn 
1               5                   10                  15      

<210>   32
<211>   7
<212>   PRT
<213>   Mus musculus

<400>   32
Arg Val Ser Thr Arg Phe Ser 
1               5           

<210>   33
<211>   9
<212>   PRT
<213>   Mus musculus

<400>   33
Leu Gln Leu Thr His Val Pro Tyr Thr 
1               5                   

<210>   34
<211>   10
<212>   PRT
<213>   Mus musculus

<400>   34
Gly Phe Thr Phe Ser Ser Ser Gly Met Ser 
1               5                   10  

<210>   35
<211>   10
<212>   PRT
<213>   Mus musculus

<400>   35
Ile Val Thr Ser Gly Gly Ser Tyr Thr Tyr 
1               5                   10  

<210>   36
<211>   9
<212>   PRT
<213>   Mus musculus

<400>   36
His Gly Val Tyr Tyr Arg Phe Asp Tyr 
1               5                   

