               SEQUENCE LISTING

<110> L'OREAL

<120> Utilisation de la proteine MMP-12 dans la prevention et/ou le traitement des peaux vieillies ou senescentes

<130> BR94550/KLP/GGJ/gg

<160> 6

<170> BiSSAP 1.0

<210> 1
<211> 365
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..365
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 1
Gly Pro Val Trp Arg Lys His Tyr Ile Thr Tyr Arg Ile Asn Asn Tyr 
1               5                   10                   15    
Thr Pro Asp Met Asn Arg Glu Asp Val Asp Tyr Ala Ile Arg Lys Ala 
            20                   25                  30        
Phe Gln Val Trp Ser Asn Val Thr Pro Leu Lys Phe Ser Lys Ile Asn 
        35                   40                  45            
Thr Gly Met Ala Asp Ile Leu Val Val Phe Ala Arg Gly Ala His Gly 
    50                   55                  60                
Asp Phe His Ala Phe Asp Gly Lys Gly Gly Ile Leu Ala His Ala Phe 
65                   70                  75                  80
Gly Pro Gly Ser Gly Ile Gly Gly Asp Ala His Phe Asp Glu Asp Glu 
                85                   90                  95    
Phe Trp Thr Thr His Ser Gly Gly Thr Asn Leu Phe Leu Thr Ala Val 
            100                  105                110        
His Glu Ile Gly His Ser Leu Gly Leu Gly His Ser Ser Asp Pro Lys 
        115                  120                125            
Ala Val Met Phe Pro Thr Tyr Lys Tyr Val Asp Ile Asn Thr Phe Arg 
    130                  135                140                
Leu Ser Ala Asp Asp Ile Arg Gly Ile Gln Ser Leu Tyr Gly Asp Pro 
145                  150                155                  160
Lys Glu Asn Gln Arg Leu Pro Asn Pro Asp Asn Ser Glu Pro Ala Leu 
                165                  170                175    
Cys Asp Pro Asn Leu Ser Phe Asp Ala Val Thr Thr Val Gly Asn Lys 
            180                  185                190        
Ile Phe Phe Phe Lys Asp Arg Phe Phe Trp Leu Lys Val Ser Glu Arg 
        195                  200                205            
Pro Lys Thr Ser Val Asn Leu Ile Ser Ser Leu Trp Pro Thr Leu Pro 
    210                  215                220                
Ser Gly Ile Glu Ala Ala Tyr Glu Ile Glu Ala Arg Asn Gln Val Phe 
225                  230                235                  240
Leu Phe Lys Asp Asp Lys Tyr Trp Leu Ile Ser Asn Leu Arg Pro Glu 
                245                  250                255    
Pro Asn Tyr Pro Lys Ser Ile His Ser Phe Gly Phe Pro Asn Phe Val 
            260                  265                270        
Lys Lys Ile Asp Ala Ala Val Phe Asn Pro Arg Phe Tyr Arg Thr Tyr 
        275                  280                285            
Phe Phe Val Asp Asn Gln Tyr Trp Arg Tyr Asp Glu Arg Arg Gln Met 
    290                  295                300                
Met Asp Pro Gly Tyr Pro Lys Leu Ile Thr Lys Asn Phe Gln Gly Ile 
305                  310                315                  320
Gly Pro Lys Ile Asp Ala Val Phe Tyr Ser Lys Asn Lys Tyr Tyr Tyr 
                325                  330                335    
Phe Phe Gln Gly Ser Asn Gln Phe Glu Tyr Asp Phe Leu Leu Gln Arg 
            340                  345                350        
Ile Thr Lys Thr Leu Lys Ser Asn Ser Trp Phe Gly Cys 
        355                  360                365

<210> 2
<211> 364
<212> PRT
<213> Mus musculus

<220> 
<221> SOURCE
<222> 1..364
<223> /mol_type="protein"
      /organism="Mus musculus"

<400> 2
Arg Ser Arg Trp Met Lys Arg Tyr Leu Thr Tyr Arg Ile Tyr Asn Tyr 
1               5                   10                   15    
Thr Pro Asp Met Lys Arg Glu Asp Val Asp Tyr Ile Phe Gln Lys Ala 
            20                   25                  30        
Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Arg Lys Leu His 
        35                   40                  45            
Lys Asp Glu Ala Asp Ile Met Ile Leu Phe Ala Phe Gly Ala His Gly 
    50                   55                  60                
Asp Phe Asn Tyr Phe Asp Gly Lys Gly Gly Thr Leu Ala His Ala Phe 
65                   70                  75                  80
Tyr Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Glu Ala Glu 
                85                   90                  95    
Thr Trp Thr Lys Ser Phe Gln Gly Thr Asn Leu Phe Leu Val Ala Val 
            100                  105                110        
His Glu Leu Gly His Ser Leu Gly Leu Gln His Ser Asn Asn Pro Lys 
        115                  120                125            
Ser Ile Met Tyr Pro Thr Tyr Arg Tyr Leu Asn Pro Ser Thr Phe Arg 
    130                  135                140                
Leu Ser Ala Asp Asp Ile Arg Asn Ile Gln Ser Leu Tyr Gly Ala Pro 
145                  150                155                  160
Val Lys Pro Pro Ser Leu Thr Lys Pro Ser Ser Pro Pro Ser Thr Phe 
                165                  170                175    
Cys His Gln Ser Leu Ser Phe Asp Ala Val Thr Thr Val Gly Glu Lys 
            180                  185                190        
Ile Phe Phe Phe Lys Asp Trp Phe Phe Trp Trp Lys Leu Pro Gly Ser 
        195                  200                205            
Pro Ala Thr Asn Ile Thr Ser Ile Ser Ser Ile Trp Pro Ser Ile Pro 
    210                  215                220                
Ser Gly Ile Gln Ala Ala Tyr Glu Ile Glu Ser Arg Asn Gln Leu Phe 
225                  230                235                  240
Leu Phe Lys Asp Glu Lys Tyr Trp Leu Ile Asn Asn Leu Val Pro Glu 
                245                  250                255    
Pro His Tyr Pro Arg Ser Ile Tyr Ser Leu Gly Phe Ser Ala Ser Val 
            260                  265                270        
Lys Lys Val Asp Ala Ala Val Phe Asp Pro Leu Arg Gln Lys Val Tyr 
        275                  280                285            
Phe Phe Val Asp Lys His Tyr Trp Arg Tyr Asp Val Arg Gln Glu Leu 
    290                  295                300                
Met Asp Pro Ala Tyr Pro Lys Leu Ile Ser Thr His Phe Pro Gly Ile 
305                  310                315                  320
Lys Pro Lys Ile Asp Ala Val Leu Tyr Phe Lys Arg His Tyr Tyr Ile 
                325                  330                335    
Phe Gln Gly Ala Tyr Gln Leu Glu Tyr Asp Pro Leu Phe Arg Arg Val 
            340                  345                350        
Thr Lys Thr Leu Lys Ser Thr Ser Trp Phe Gly Cys 
        355                  360                

<210> 3
<211> 364
<212> PRT
<213> Rattus norvegicus

<220> 
<221> SOURCE
<222> 1..364
<223> /mol_type="protein"
      /organism="Rattus norvegicus"

<400> 3
Arg Ser Arg Trp Met Lys Arg Tyr Leu Thr Tyr Arg Ile Tyr Asn Tyr 
1               5                   10                   15    
Thr Pro Asp Met Lys Arg Ala Asp Val Asp Tyr Ile Phe Gln Lys Ala 
            20                   25                  30        
Phe Gln Val Trp Ser Asp Val Thr Pro Leu Arg Phe Arg Lys Ile His 
        35                   40                  45            
Lys Gly Glu Ala Asp Ile Thr Ile Leu Phe Ala Phe Gly Asp His Gly 
    50                   55                  60                
Asp Phe Tyr Asp Phe Asp Gly Lys Gly Gly Thr Leu Ala His Ala Phe 
65                   70                  75                  80
Tyr Pro Gly Pro Gly Ile Gln Gly Asp Ala His Phe Asp Glu Ala Glu 
                85                   90                  95    
Thr Trp Thr Lys Ser Phe Gln Gly Thr Asn Leu Phe Leu Val Ala Val 
            100                  105                110        
His Glu Leu Gly His Ser Leu Gly Leu Pro His Ser Asn Asn Pro Lys 
        115                  120                125            
Ser Ile Met Tyr Pro Thr Tyr Arg Tyr Leu His Pro Asn Thr Phe Arg 
    130                  135                140                
Leu Ser Ala Asp Asp Ile His Ser Ile Gln Ser Leu Tyr Gly Ala Pro 
145                  150                155                  160
Val Lys Asn Pro Ser Leu Thr Asn Pro Gly Ser Pro Pro Ser Thr Val 
                165                  170                175    
Cys His Gln Ser Leu Ser Phe Asp Ala Val Thr Thr Val Gly Asp Lys 
            180                  185                190        
Ile Phe Phe Phe Lys Asp Trp Phe Phe Trp Trp Arg Leu Pro Gly Ser 
        195                  200                205            
Pro Ala Thr Asn Ile Thr Ser Ile Ser Ser Met Trp Pro Thr Ile Pro 
    210                  215                220                
Ser Gly Ile Gln Ala Ala Tyr Glu Ile Gly Gly Arg Asn Gln Leu Phe 
225                  230                235                  240
Leu Phe Lys Asp Glu Lys Tyr Trp Leu Ile Asn Asn Leu Val Pro Glu 
                245                  250                255    
Pro His Tyr Pro Arg Ser Ile His Ser Leu Gly Phe Pro Ala Ser Val 
            260                  265                270        
Lys Lys Ile Asp Ala Ala Val Phe Asp Pro Leu Arg Gln Lys Val Tyr 
        275                  280                285            
Phe Phe Val Asp Lys Gln Tyr Trp Arg Tyr Asp Val Arg Gln Glu Leu 
    290                  295                300                
Met Asp Ala Ala Tyr Pro Lys Leu Ile Ser Thr His Phe Pro Gly Ile 
305                  310                315                  320
Arg Pro Lys Ile Asp Ala Val Leu Tyr Phe Lys Arg His Tyr Tyr Ile 
                325                  330                335    
Phe Gln Gly Ala Tyr Gln Leu Glu Tyr Asp Pro Leu Leu His Arg Val 
            340                  345                350        
Thr Lys Thr Leu Ser Ser Thr Ser Trp Phe Gly Cys 
        355                  360                

<210> 4
<211> 20
<212> PRT
<213> Homo sapiens

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="protein"
      /organism="Homo sapiens"

<400> 4
Ala Arg Asn Gln Val Phe Leu Phe Lys Asp Asp Lys Tyr Trp Leu Ile 
1               5                   10                   15    
Ser Asn Leu Arg 
            20

<210> 5
<211> 20
<212> PRT
<213> Mus musculus

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="protein"
      /organism="Mus musculus"

<400> 5
Gly Arg Asn Gln Leu Phe Leu Phe Lys Asp Glu Lys Tyr Trp Leu Ile 
1               5                   10                   15    
Asn Asn Leu Val 
            20

<210> 6
<211> 20
<212> PRT
<213> Rattus norvegicus

<220> 
<221> SOURCE
<222> 1..20
<223> /mol_type="protein"
      /organism="Rattus norvegicus"

<400> 6
Ser Arg Asn Gln Leu Phe Leu Phe Lys Asp Glu Lys Tyr Trp Leu Ile 
1               5                   10                   15    
Asn Asn Leu Val 
            20

