                         SEQUENCE LISTING

<110>  Synthon Biopharmaceuticals B.V.
       Ariaans, Gerry
       Nolan, Declan
       van Dalen, Frans
 
<120>  COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS

<130>  P1553US00

<150>  US 61/576,922
<151>  2011-12-16

<150>  US 61/576,727
<151>  2011-12-16

<160>  21    

<170>  PatentIn version 3.5

<210>  1
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       ustekinumab (CTNO-1275).

<400>  1

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  2
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       ustekinumab (CTNO-1275).

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       briakinumab (CJ-695, ABT-874).

<400>  3

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Thr His Gly Ser His Asp Asn Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  4
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       briakinumab (J-695, ABT-874).

<400>  4

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Lys Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Tyr Thr 
                85                  90                  95      


His Pro Ala Leu Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  5
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  6
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  6

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  7
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  8
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  9
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  9

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  10
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  10

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  11
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  12
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  12

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Ala Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  13
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  14
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  15
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  16
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  16

Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu Gly Asn 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn Arg His 
            20                  25                  30          


Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys Ile Thr 
        35                  40                  45              


Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly Arg Ala 
    50                  55                  60                  


Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn Ile Ala 
65                  70                  75                  80  


Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu Gly Ile 
                85                  90                  95      


Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser Gln Gly 
            100                 105                 110         


Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu Gly Arg 
        115                 120                 125             


Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln Lys Arg 
    130                 135                 140                 


Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val Ile Asp 
145                 150                 155                 160 


Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg Leu Asp 
                165                 170                 175     


Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn Gln Leu 
            180                 185                 190         


Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp Asp Ser 
        195                 200                 205             


Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro Glu Pro 
    210                 215                 220                 


Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His Cys Ala 
225                 230                 235                 240 


Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg Gln Ser 
                245                 250                 255     


Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys Arg Ala 
            260                 265                 270         


Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys Asp Gly 
        275                 280                 285             


Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala Gly Arg 
    290                 295                 300                 


Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly Ser Pro 
305                 310                 315                 320 


Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile Pro Arg 
                325                 330                 335     


Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala Val Leu 
            340                 345                 350         


Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp Cys Leu 
        355                 360                 365             


Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp Ser Glu 
    370                 375                 380                 


Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu Glu Glu 
385                 390                 395                 400 


Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr Ser Arg 
                405                 410                 415     


Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu Trp Arg 
            420                 425                 430         


Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu Lys Val 
        435                 440                 445             


Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val Pro Cys 
    450                 455                 460                 


His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys Lys Trp 
465                 470                 475                 480 


Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly Pro Ser 
                485                 490                 495     


Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser Leu Thr 
            500                 505                 510         


Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys Gly Val 
        515                 520                 525             


Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val Ala Val 
    530                 535                 540                 


Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala Lys Ala 
545                 550                 555                 560 


Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg Glu Ile 
                565                 570                 575     


Glu Asn Lys Ala Ile Gln Asp Pro Arg 
            580                 585 


<210>  17
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a signal peptide (secretion signal).

<400>  17

Met Gln Val Leu Asn Thr Met Val Asn Lys His Phe Leu Ser Leu Ser 
1               5                   10                  15      


Val Leu Ile Val Leu Leu Gly Leu Ser Ser Asn Leu Thr Ala Gly 
            20                  25                  30      


<210>  18
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lemna-optimized complete SILA heavy chain IgA1 DNA (including 
       signal peptide SEQ ID NO:17).

<400>  18
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcgaggtcc agctggtgca gtccggcgcg      120

gaggtcaaga agcctgggga atccctgaag atcagctgca agggcagcgg gtacagcttc      180

accacttact ggctcggctg ggtgcgccag atgccgggca aggggctgga ctggatcggg      240

atcatgtccc ccgtggactc cgacatccgg tactccccga gcttccaggg ccaggtcact      300

atgtccgtgg acaagagcat caccacggcc tacttgcagt ggaactccct gaaggcgagc      360

gataccgcga tgtactattg cgcgagacgg agacccgggc agggctactt cgacttctgg      420

gggcagggca ccctggtgac ggtgtcctca gcctcgccca cgtcgccgaa ggtcttcccc      480

ctcagcctct gctcgacgca gcccgacggg aacgttgtca tcgcctgcct cgtgcagggc      540

ttcttcccgc aggagccgct ctccgtgacc tggtccgaga gcggccaggg cgttaccgct      600

cggaacttcc cgccctccca ggacgcgagc ggcgatctct acactacgtc ctcgcagctt      660

acgctcccgg cgacgcaatg cctcgccggc aagagcgtga cgtgccacgt caagcactac      720

accaatccct cgcaggacgt gaccgtgccc tgcccggtgc cttccacgcc tccgacgccg      780

agcccgtcca cgccgccgac cccttcgccc agctgctgtc acccgcgcct ctccctccac      840

cggcccgccc tggaggacct gttgctcggg agcgaggcga acctcacctg cacgctcacg      900

ggcctgcgcg acgcctctgg cgttaccttc acctggacgc cctcttccgg gaagagcgcc      960

gtgcagggcc cgcccgagag agacctctgc ggttgctact ccgtgtcgag cgtgctcccg     1020

gggtgcgcgg agccgtggaa ccacgggaag accttcacct gcaccgcggc ctaccctgag     1080

tccaagacgc ccctgaccgc caccctgtcc aagtccggga acaccttccg cccggaggtg     1140

cacttgctgc caccgcccag cgaggaactc gccctgaacg agctggtcac gctcacctgc     1200

ctggctaggg gcttctcgcc caaggacgtg ctggtccgct ggttgcaagg cagccaggag     1260

ctgccgcgcg agaagtacct cacctgggcc tctaggcagg agccctcgca gggcaccact     1320

acgttcgcgg tgacctccat cctcagggtc gccgctgagg actggaagaa aggcgacacc     1380

ttctcctgca tggtcggcca cgaggcgctg cccctcgcct tcacccagaa gaccatcgac     1440

cggctggccg ggaagcccac ccacgtcaac gtcagcgtcg ttatggctga ggttgacggg     1500

acgtgctac                                                             1509


<210>  19
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lemna-optimized complete SILA light chain DNA (including signal 
       peptide SEQ ID NO:17).

<400>  19
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcgacatcc agatgacgca gagcccgtcg      120

agcctgtccg cctccgtcgg ggacagggtc acgatcacct gcagagccag ccagggcatc      180

tcgtcctggc tggcctggta tcaacagaag cccgagaagg ctccgaagtc cctgatctac      240

gcggccagct ccctccagag cggcgtcccg agccggttct ccggcagcgg ctccggcacc      300

gacttcaccc tcaccatcag ctcgctccag cccgaggact tcgccaccta ctactgccag      360

cagtacaaca tctacccgta cacgttcggg cagggcacga agctggagat caagcgcacg      420

gtggccgcgc ccagcgtctt catcttcccg ccctcggacg agcagctgaa gtccggcact      480

gcctccgtgg tctgcctgct caacaacttc tacccccgcg aagccaaggt gcagtggaag      540

gttgacaacg cgctccagag cgggaactcc caggagtccg tgaccgagca ggactccaag      600

gactccacct acagcctgtc cagcaccctc accctctcca aggccgacta cgagaagcac      660

aaggtgtacg cctgcgaggt gacccaccag ggcctctcct ccccggtgac caagtccttc      720

aaccgcggtg agtgc                                                       735


<210>  20
<211>  504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lemna-optimized complete human J-chain DNA (including signal 
       peptide SEQ ID NO:17).

<400>  20
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggccaggagg acgagcgcat cgtcctcgtg      120

gacaacaagt gcaagtgcgc gcgcatcacc agccgcatca tccggtccag cgaggacccc      180

aacgaggaca tcgtcgagcg caacatccgc atcatcgtgc ccctgaacaa ccgcgagaac      240

atctccgacc cgacctcccc gctgaggacc cgcttcgtgt accacctgag cgacctctgc      300

aagaagtgcg accccaccga ggtggaactc gacaaccaga tcgtcacggc cacccagagc      360

aacatctgcg acgaggactc cgccaccgag acgtgctaca cctacgacag gaacaagtgc      420

tacacggccg tcgtgcccct cgtgtacggc ggggagacca agatggtcga gacggccctg      480

accccggacg cgtgctaccc cgac                                             504


<210>  21
<211>  1848
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lemna-optimized complete human SC-chain DNA (including signal 
       peptide SEQ ID NO:17).

<400>  21
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcaagtccc cgatcttcgg gccggaggaa      120

gtgaactcgg tggaggggaa ctccgtcagc atcacctgct actatcctcc gacgagcgtg      180

aaccggcaca cgaggaagta ctggtgcagg caaggggcca gaggcgggtg catcaccctc      240

atctccagcg aggggtacgt ctcgtccaag tacgccggtc gcgccaacct cacgaacttc      300

cccgagaacg ggacgttcgt tgtgaacatc gcccagctgt cgcaggacga cagcggccgc      360

tacaagtgtg gcctcgggat caacagccgc gggctctcct tcgacgtctc gctggaggtg      420

tcccagggcc ccggcctcct gaacgacacg aaagtgtaca ccgttgacct cggccggacg      480

gtcactatca actgcccgtt caagaccgag aacgcccaga agcgcaagag cctctacaag      540

cagatcggcc tctacccggt cctggtgatc gactcctcgg gctacgtcaa cccgaactac      600

accggccgca tccggctgga catccagggg accgggcagc tgctcttctc cgtggtcatc      660

aaccagctcc gcctgagcga cgccgggcag tacctgtgcc aggccgggga cgatagcaac      720

tccaacaaga agaacgccga cctccaagtg ctgaagcccg agccggagct ggtctacgag      780

gacctccgcg ggtccgtgac cttccactgc gccctgggcc cggaggtcgc caacgtggcg      840

aagttcctgt gccggcagtc ctcgggtgag aactgcgacg tggtcgtgaa caccctcggg      900

aagcgcgcgc ccgccttcga gggccgcatc ctgctcaatc cccaggacaa ggacgggtcc      960

ttcagcgtgg tcatcacggg cctccgcaag gaagacgcgg gccgctacct ctgcggcgcc     1020

cactcggacg gccagctcca ggaggggagc cccatccagg cctggcagct gttcgtcaac     1080

gaggagtcca cgatccccag aagccccacc gtggttaagg gcgtcgccgg tggctccgtg     1140

gcggtgctgt gcccgtacaa ccgcaaggag agcaagtcca tcaagtactg gtgcctgtgg     1200

gagggcgccc agaacgggag atgcccgctc ctggtggact ccgaggggtg ggtgaaggcg     1260

cagtacgagg gccgcctctc gctcctggag gagcccggca acggcacctt caccgtcatc     1320

ctcaaccagc tgacgtcgcg ggacgccggc ttctactggt gcctcaccaa cggcgacacc     1380

ctctggagga ccacggtgga gatcaagatc atcgagggcg agccgaacct gaaagtccct     1440

gggaacgtga ccgctgtcct cggcgagacc ctgaaggtgc cctgccactt cccctgcaag     1500

ttctccagct acgagaagta ctggtgcaag tggaacaaca ccggctgtca ggccctcccc     1560

tcgcaggacg aggggccgtc caaggcgttc gtgaactgcg acgagaacag ccgcctcgtg     1620

tccctcaccc tcaacctcgt gacccgcgcc gacgagggct ggtactggtg cggggtgaag     1680

cagggccact tctacgggga gaccgccgcg gtctacgtgg cggtcgagga gcgcaaggcc     1740

gctggctccc gcgacgtcag cctggccaag gccgacgccg cgcccgacga gaaggtgctg     1800

gactccgggt tccgggagat cgagaacaag gccatccagg atccccgg                  1848


