                         SEQUENCE LISTING

<110>  Synthon Biopharmaceuticals B.V.
       Ariaans, Gerry
       Nolan, Declan
       van Dalen, Frans
 
<120>  COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY DISEASES

<130>  P1608PC00

<150>  US 61/576,922
<151>  2011-12-16

<150>  US 61/576,727
<151>  2011-12-16

<160>  42    

<170>  PatentIn version 3.5

<210>  1
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the soluble TNFalpha receptor of 
       etanercept (extracellular part of TNF receptor 2: amino acids 
       23-257 of UniProtKB/Swiss-Prot database entry P20333 
       TNR1B_HUMAN).

<400>  1

Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser 
1               5                   10                  15      


Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys 
            20                  25                  30          


Ser Lys Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr 
        35                  40                  45              


Ser Asp Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu 
    50                  55                  60                  


Trp Asn Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser 
65                  70                  75                  80  


Asp Gln Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys 
                85                  90                  95      


Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys 
            100                 105                 110         


Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala 
        115                 120                 125             


Arg Pro Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro 
    130                 135                 140                 


Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His 
145                 150                 155                 160 


Gln Ile Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala 
                165                 170                 175     


Val Cys Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val 
            180                 185                 190         


His Leu Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr 
        195                 200                 205             


Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly 
    210                 215                 220                 


Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly Asp 
225                 230                 235 


<210>  2
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       infliximab (cA2).

<400>  2

Glu Val Lys Leu Glu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Met Lys Leu Ser Cys Val Ala Ser Gly Phe Ile Phe Ser Asn His 
            20                  25                  30          


Trp Met Asn Trp Val Arg Gln Ser Pro Glu Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Lys Ser Ile Asn Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Ser Ala 
65                  70                  75                  80  


Val Tyr Leu Gln Met Thr Asp Leu Arg Thr Glu Asp Thr Gly Val Tyr 
                85                  90                  95      


Tyr Cys Ser Arg Asn Tyr Tyr Gly Ser Thr Tyr Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Thr Leu Thr Val Ser Ser 
        115                 120 


<210>  3
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       infliximab (cA2).

<400>  3

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Phe Val Gly Ser Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Met Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Thr Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser His Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Asn Leu Glu Val Lys 
            100                 105         


<210>  4
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       adalimumab (D2E7).

<400>  4

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  5
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       adalimumab (D2E7).

<400>  5

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  6
<211>  126
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       golimumab.

<400>  6

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Met Ser Tyr Asp Gly Ser Asn Lys Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Arg Gly Ile Ala Ala Gly Gly Asn Tyr Tyr Tyr Tyr Gly 
            100                 105                 110         


Met Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 125     


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       golimumab.

<400>  7

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Tyr Ser Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Pro 
                85                  90                  95      


Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 
            100                 105             


<210>  8
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       certolizumab pegol.

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Val Phe Thr Asp Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Ile Gly Glu Pro Ile Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Arg Ser Tyr Ala Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  9
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       certolizumab pegol.

<400>  9

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asn Val Gly Thr Asn 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Ala Leu Ile 
        35                  40                  45              


Tyr Ser Ala Ser Phe Leu Tyr Ser Gly Val Pro Tyr Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  10
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  10

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Ser Thr Pro Pro Thr Pro Ser Pro 
            100                 105                 110         


Ser Thr Pro Pro Thr Pro Ser Pro Ser Cys Cys His Pro Arg Leu Ser 
        115                 120                 125             


Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser Glu Ala Asn 
    130                 135                 140                 


Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly Val Thr Phe 
145                 150                 155                 160 


Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly Pro Pro Glu 
                165                 170                 175     


Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu Pro Gly Cys 
            180                 185                 190         


Ala Glu Pro Trp Asn His Gly Lys Thr Phe Thr Cys Thr Ala Ala Tyr 
        195                 200                 205             


Pro Glu Ser Lys Thr Pro Leu Thr Ala Thr Leu Ser Lys Ser Gly Asn 
    210                 215                 220                 


Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu Glu Leu 
225                 230                 235                 240 


Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly Phe Ser 
                245                 250                 255     


Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu Leu Pro 
            260                 265                 270         


Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser Gln Gly 
        275                 280                 285             


Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala Glu Asp 
    290                 295                 300                 


Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu Ala Leu 
305                 310                 315                 320 


Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly Lys Pro 
                325                 330                 335     


Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly Thr Cys 
            340                 345                 350         


Tyr 
    


<210>  11
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  11

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  12
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  12

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Tyr Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Glu Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Met Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Ile Asn Val Ser Val Val Met Ala Glu Ala Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  13
<211>  340
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Ser Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Arg Val Pro Pro Pro Pro Pro Cys Cys His Pro 
            100                 105                 110         


Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu Leu Leu Gly Ser 
        115                 120                 125             


Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg Asp Ala Ser Gly 
    130                 135                 140                 


Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser Ala Val Gln Gly 
145                 150                 155                 160 


Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val Ser Ser Val Leu 
                165                 170                 175     


Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr Phe Thr Cys Thr 
            180                 185                 190         


Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala Asn Ile Thr Lys 
        195                 200                 205             


Ser Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser 
    210                 215                 220                 


Glu Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg 
225                 230                 235                 240 


Gly Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln 
                245                 250                 255     


Glu Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro 
            260                 265                 270         


Ser Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala 
        275                 280                 285             


Ala Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His 
    290                 295                 300                 


Glu Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala 
305                 310                 315                 320 


Gly Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp 
                325                 330                 335     


Gly Thr Cys Tyr 
            340 


<210>  14
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  15
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  16
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  17
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Ala Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  18
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  19
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  20
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Glu Asp Glu Arg Ile Val Leu Val Asp Asn Lys Cys Lys Cys Ala 
1               5                   10                  15      


Arg Ile Thr Ser Arg Ile Ile Arg Ser Ser Glu Asp Pro Asn Glu Asp 
            20                  25                  30          


Ile Val Glu Arg Asn Ile Arg Ile Ile Val Pro Leu Asn Asn Arg Glu 
        35                  40                  45              


Asn Ile Ser Asp Pro Thr Ser Pro Leu Arg Thr Arg Phe Val Tyr His 
    50                  55                  60                  


Leu Ser Asp Leu Cys Lys Lys Cys Asp Pro Thr Glu Val Glu Leu Asp 
65                  70                  75                  80  


Asn Gln Ile Val Thr Ala Thr Gln Ser Asn Ile Cys Asp Glu Asp Ser 
                85                  90                  95      


Ala Thr Glu Thr Cys Tyr Thr Tyr Asp Arg Asn Lys Cys Tyr Thr Ala 
            100                 105                 110         


Val Val Pro Leu Val Tyr Gly Gly Glu Thr Lys Met Val Glu Thr Ala 
        115                 120                 125             


Leu Thr Pro Asp Ala Cys Tyr Pro Asp 
    130                 135         


<210>  21
<211>  585
<212>  PRT
<213>  Homo sapiens

<400>  21

Lys Ser Pro Ile Phe Gly Pro Glu Glu Val Asn Ser Val Glu Gly Asn 
1               5                   10                  15      


Ser Val Ser Ile Thr Cys Tyr Tyr Pro Pro Thr Ser Val Asn Arg His 
            20                  25                  30          


Thr Arg Lys Tyr Trp Cys Arg Gln Gly Ala Arg Gly Gly Cys Ile Thr 
        35                  40                  45              


Leu Ile Ser Ser Glu Gly Tyr Val Ser Ser Lys Tyr Ala Gly Arg Ala 
    50                  55                  60                  


Asn Leu Thr Asn Phe Pro Glu Asn Gly Thr Phe Val Val Asn Ile Ala 
65                  70                  75                  80  


Gln Leu Ser Gln Asp Asp Ser Gly Arg Tyr Lys Cys Gly Leu Gly Ile 
                85                  90                  95      


Asn Ser Arg Gly Leu Ser Phe Asp Val Ser Leu Glu Val Ser Gln Gly 
            100                 105                 110         


Pro Gly Leu Leu Asn Asp Thr Lys Val Tyr Thr Val Asp Leu Gly Arg 
        115                 120                 125             


Thr Val Thr Ile Asn Cys Pro Phe Lys Thr Glu Asn Ala Gln Lys Arg 
    130                 135                 140                 


Lys Ser Leu Tyr Lys Gln Ile Gly Leu Tyr Pro Val Leu Val Ile Asp 
145                 150                 155                 160 


Ser Ser Gly Tyr Val Asn Pro Asn Tyr Thr Gly Arg Ile Arg Leu Asp 
                165                 170                 175     


Ile Gln Gly Thr Gly Gln Leu Leu Phe Ser Val Val Ile Asn Gln Leu 
            180                 185                 190         


Arg Leu Ser Asp Ala Gly Gln Tyr Leu Cys Gln Ala Gly Asp Asp Ser 
        195                 200                 205             


Asn Ser Asn Lys Lys Asn Ala Asp Leu Gln Val Leu Lys Pro Glu Pro 
    210                 215                 220                 


Glu Leu Val Tyr Glu Asp Leu Arg Gly Ser Val Thr Phe His Cys Ala 
225                 230                 235                 240 


Leu Gly Pro Glu Val Ala Asn Val Ala Lys Phe Leu Cys Arg Gln Ser 
                245                 250                 255     


Ser Gly Glu Asn Cys Asp Val Val Val Asn Thr Leu Gly Lys Arg Ala 
            260                 265                 270         


Pro Ala Phe Glu Gly Arg Ile Leu Leu Asn Pro Gln Asp Lys Asp Gly 
        275                 280                 285             


Ser Phe Ser Val Val Ile Thr Gly Leu Arg Lys Glu Asp Ala Gly Arg 
    290                 295                 300                 


Tyr Leu Cys Gly Ala His Ser Asp Gly Gln Leu Gln Glu Gly Ser Pro 
305                 310                 315                 320 


Ile Gln Ala Trp Gln Leu Phe Val Asn Glu Glu Ser Thr Ile Pro Arg 
                325                 330                 335     


Ser Pro Thr Val Val Lys Gly Val Ala Gly Gly Ser Val Ala Val Leu 
            340                 345                 350         


Cys Pro Tyr Asn Arg Lys Glu Ser Lys Ser Ile Lys Tyr Trp Cys Leu 
        355                 360                 365             


Trp Glu Gly Ala Gln Asn Gly Arg Cys Pro Leu Leu Val Asp Ser Glu 
    370                 375                 380                 


Gly Trp Val Lys Ala Gln Tyr Glu Gly Arg Leu Ser Leu Leu Glu Glu 
385                 390                 395                 400 


Pro Gly Asn Gly Thr Phe Thr Val Ile Leu Asn Gln Leu Thr Ser Arg 
                405                 410                 415     


Asp Ala Gly Phe Tyr Trp Cys Leu Thr Asn Gly Asp Thr Leu Trp Arg 
            420                 425                 430         


Thr Thr Val Glu Ile Lys Ile Ile Glu Gly Glu Pro Asn Leu Lys Val 
        435                 440                 445             


Pro Gly Asn Val Thr Ala Val Leu Gly Glu Thr Leu Lys Val Pro Cys 
    450                 455                 460                 


His Phe Pro Cys Lys Phe Ser Ser Tyr Glu Lys Tyr Trp Cys Lys Trp 
465                 470                 475                 480 


Asn Asn Thr Gly Cys Gln Ala Leu Pro Ser Gln Asp Glu Gly Pro Ser 
                485                 490                 495     


Lys Ala Phe Val Asn Cys Asp Glu Asn Ser Arg Leu Val Ser Leu Thr 
            500                 505                 510         


Leu Asn Leu Val Thr Arg Ala Asp Glu Gly Trp Tyr Trp Cys Gly Val 
        515                 520                 525             


Lys Gln Gly His Phe Tyr Gly Glu Thr Ala Ala Val Tyr Val Ala Val 
    530                 535                 540                 


Glu Glu Arg Lys Ala Ala Gly Ser Arg Asp Val Ser Leu Ala Lys Ala 
545                 550                 555                 560 


Asp Ala Ala Pro Asp Glu Lys Val Leu Asp Ser Gly Phe Arg Glu Ile 
                565                 570                 575     


Glu Asn Lys Ala Ile Gln Asp Pro Arg 
            580                 585 


<210>  22
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Lys Asn His Leu Leu Phe Trp Gly Val Leu Ala Val Phe Ile Lys 
1               5                   10                  15      


Ala Val His Val Lys Ala 
            20          


<210>  23
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a signal peptide (heavy chain secretion 
       signal).

<400>  23

Met Glu Leu Gly Leu Cys Trp Val Phe Leu Val Ala Ile Leu Glu Gly 
1               5                   10                  15      


Val Gln Cys 
            


<210>  24
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a signal peptide (light chain secretion 
       signal).

<400>  24

Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 
1               5                   10                  15      


Ala Gln Pro Ala Met Ala 
            20          


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for a signal peptide (SC chain secretion 
       signal).

<400>  25

Met Ala Met Leu Leu Phe Val Leu Thr Cys Leu Leu Ala Val Phe Pro 
1               5                   10                  15      


Ala Ile Ser Thr 
            20  


<210>  26
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence for rice alpha-amylase signal peptide 
       (secretion signal).

<400>  26

Met Gln Val Leu Asn Thr Met Val Asn Lys His Phe Leu Ser Leu Ser 
1               5                   10                  15      


Val Leu Ile Val Leu Leu Gly Leu Ser Ser Asn Leu Thr Ala Gly 
            20                  25                  30      


<210>  27
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for infliximab heavy chain IgA2m(n) optimized for 
       maize.

<400>  27
atggagctgg gcctgtgctg ggtgttcctg gtggccatcc tcgagggcgt ccagtgcgag       60

gtgaagctcg aggagtccgg cggcggcctg gtccagcctg gcggctccat gaagctgtcc      120

tgcgtggcct ccggcttcat cttctccaac cactggatga actgggtgcg ccagtccccc      180

gagaagggcc tcgagtgggt ggccgagatc cgctccaagt ccatcaactc cgccacccac      240

tacgccgagt ccgtcaaggg caggttcacc atctcccgcg acgactccaa gtccgccgtg      300

tacctccaga tgaccgacct gcgcaccgag gacaccggcg tgtactactg ctcccgcaac      360

tactacggct ccacctacga ctactggggc cagggcacca ccctgaccgt gtcctccgct      420

agccccacct cccccaaggt gttccccctg tccctggact ccacccccca ggacggcaac      480

gtggtggtgg cctgcctggt ccagggcttc ttcccccagg agcccctgtc cgtcacctgg      540

agcgagtccg gccagaacgt gaccgcccgc aacttccccc cctcccagga cgcttccggc      600

gacctgtaca ccacctcctc ccagctgacc ctgcccgcta cccagtgccc cgacggcaag      660

tccgtgacct gccacgtgaa gcactacacc aactccagcc aggacgtgac cgtgccctgc      720

cgcgtgcctc ctccccctcc ctgctgccac cccaggctgt ccctgcacag gcccgctctc      780

gaggacctgc tgctgggctc cgaggccaac ctgacctgca ccctgaccgg cctgagggac      840

gcctccggcg ctaccttcac ctggaccccc tcctccggca agtccgctgt ccaaggccca      900

cctgagcgtg atctctgcgg ctgctactcc gtgtccagcg tgctgcccgg ctgcgcccag      960

ccctggaacc acggcgagac cttcacctgc accgccgctc accccgagct taagaccccc     1020

ctgaccgcca acatcaccaa gtccggcaac accttccgcc ccgaggtgca cctgctgccc     1080

cctccctccg aggagctggc cctgaacgag ctggtgaccc tgacctgcct cgccaggggc     1140

ttctccccga aggacgtgct tgtgcgctgg ctccagggct cccaggagct gccccgcgag     1200

aagtacctga cctgggcctc caggcaggag ccttcccagg gcaccaccac cttcgccgtg     1260

acctccatcc tgagggtggc cgccgaggac tggaagaagg gcgacacctt cagctgcatg     1320

gtgggtcacg aggctctgcc cctggccttc acccaaaaga ccatcgaccg cctggctggc     1380

aagcccaccc acgtgaacgt gtccgtggtg atggccgagg tggacggcac ctgctactga     1440


<210>  28
<211>  6910
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for infliximab heavy chain IgA1 and light chain 
       kappa optimized for HEK.

<400>  28
gcttcgcgat gtacgggcca gatatacgcg ttgacattga ttattgacta gttattaata       60

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      120

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      180

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      240

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      300

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      360

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      420

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      480

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      540

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      600

ctatataagc agagctctct ggctaactag agaacccact gcttactggc ttatcgaaat      660

taatacgact cactataggg agacccaagc tagcttggta ccgggccgac ctcaccatgg      720

gatggagctg tatcatcctc ttcttggtag caacagctac aggtaagggg ctcacagtag      780

caggcttgag gtctggacat atatatgggt gacaatgaca tccactttgc ctttctctcc      840

acaggtgtgc attccgaagt gaagctggag gagtctggag gcggcttggt gcaacctgga      900

ggctccatga aactctcctg tgttgcctct ggattcattt tcagtaacca ctggatgaac      960

tgggtccgcc agtctccaga gaaggggctt gaatgggttg ctgaaattag atcaaaatcc     1020

attaattctg caacacatta tgccgagtct gtgaaaggga ggttcaccat ctcaagagat     1080

gattccaaaa gtgctgtgta cctgcaaatg accgacctga gaactgaaga cactggcgtt     1140

tattactgtt ccaggaatta ctacggtagt acctacgact actggggcca aggcaccact     1200

ctcacagtgt cctcaggtga gtcgtacgct agcaagcttg atgacctggg ctgagctgga     1260

ctaagctggg ctgacctggg ctgggatggg atgggctagg atgacttggg ctggactggg     1320

cgggactgag ctggactggc ctgggctgag ctgggctggg ctggactgag ctggactggc     1380

ctgggctggg ctgggcggga tgggctgagg tggctgctaa tgtgggaaag aggccgtggg     1440

ttgagtgtga ttccacctgc agagccctga gcccagctgt gttcttaggg gttctgaggg     1500

ccacgcagct ctgttgcacc atgattctgt cttctctctt gcccactgcc tgaaggaaat     1560

ttggagtggg ctgggcccag agctcccctg tatagcaggc cctgtcctgg agggcctggc     1620

agggacatgg cttagcctgt tggcctctag tcccgagacc tcataggcca caggggtcca     1680

ctgtggcttg tttgggcctg gggtggggct catggagtgg tgggtgttgg actgagactc     1740

tgaccaggga cagggggatg gggtcacagc caagccactc cacccctacc ccatgcacac     1800

agcactcaga gcccagaccc tctcctaaga gcccccacca aaatcctctc taggggcagg     1860

ggatagagca agacatgtcc cccacccaga gcaggggctg cggtcaggga gctcagggga     1920

ctcagccact ccatggcaga gccctgttta atacaacttg tgtctgggat ggcctggatc     1980

agagacccta tctaaggagc atgttcagaa accatgttgc tgggatcaga cagcagggtc     2040

caactgcagg cctgtggtgc aggagctgtg tgaccatggg gctgtcacca ggcctctctg     2100

tgctgggttc ctccagtata gaggagaggc agtatagagg agagggccgc gtcctcacag     2160

tgcattctgt gttccagcat ccccgaccag ccccaaggtc ttcccgctga gcctctgcag     2220

cacccagcca gatgggaacg tggtcatcgc ctgcctggtc cagggcttct tcccccagga     2280

gccactcagt gtgacctgga gcgaaagcgg acagggcgtg accgccagaa acttcccacc     2340

cagccaggat gcctccgggg acctgtacac cacgagcagc cagctgaccc tgccggccac     2400

acagtgccta gccggcaagt ccgtgacatg ccacgtgaag cactacacga atcccagcca     2460

ggatgtgact gtgccctgcc caggtcagag ggcaggctgg ggagtggggc ggggccaccc     2520

cgtcgtgccc tgacactgcg cctgcacccg tgttccccac agggagccgc cccttcactc     2580

acaccagagt ggaccgcggg ccgagcccca ggaggtggtg gtggacaggc caggaggggc     2640

gaggcggggg catggggaag tatgtgctga ccagctcagg ccatctctcc actccagttc     2700

cctcaactcc acctacccca tctccctcaa ctccacctac cccatctccc tcatgctgcc     2760

acccccgact gtcactgcac cgaccggccc tcgaggacct gctcttaggt tcagaagcga     2820

acctcacgtg cacactgacc ggcctgagag atgcctcagg tgtcaccttc acctggacgc     2880

cctcaagtgg gaagagcgct gttcaaggac cacctgagcg tgacctctgt ggctgctaca     2940

gcgtgtccag tgtcctgccg ggctgtgccg agccatggaa ccatgggaag accttcactt     3000

gcactgctgc ctaccccgag tccaagaccc cgctaaccgc caccctctca aaatccggtg     3060

ggtccagacc ctgctcgggg ccctgctcag tgctctggtt tgcaaagcat attcctggcc     3120

tgcctcctcc ctcccaatcc tgggctccag tgctcatgcc aagtacagag ggaaactgag     3180

gcaggctgag gggccaggac acagcccggg gtgcccacca gagcagaggg gctctctcat     3240

cccctgccca gccccctgac ctggctctct accctccagg aaacacattc cggcccgagg     3300

tccacctgct gccgccgccg tcggaggagc tggccctgaa cgagctggtg acgctgacgt     3360

gcctggcacg cggcttcagc cccaaggacg tgctggttcg ctggctgcag gggtcacagg     3420

agctgccccg cgagaagtac ctgacttggg catcccggca ggagcccagc cagggcacca     3480

ccaccttcgc tgtgaccagc atactgcgcg tggcagccga ggactggaag aagggggaca     3540

ccttctcctg catggtgggc cacgaggccc tgccgctggc cttcacacag aagaccatcg     3600

accgcttggc gggtaaaccc acccatgtca atgtgtctgt tgtcatggcg gaggtggacg     3660

gcacctgcta ctgagccgcc cgcctgtccc cacccctgaa taaactccat gctcccccaa     3720

gcagccccac gcttccatcc ggcgcctgtc tgtccatcct cagggtctca gcacttggga     3780

aagggccagg gcatggacag ggaagaatac cccctgccct gagcctcggg gggcccctgg     3840

cacccccatg agactttcca ccctggtgtg agtgtgagtt gtgagtgtga gagtgtgtgg     3900

tgcaggaggc ctcgctggtg tgagatccac tagttctaga ggatctcccg atcccctatg     3960

gtgcactctc agtacaatct gctctgatgc cgcatagtta agccagtatc tgctccctgc     4020

ttgtgtgttg gaggtcgctg agtagtgcgc gagcaaaatt taagctacaa caaggcaagg     4080

cttgaccgac aattaattgc atgaagaatc tgcttagggt taggcgtttt gcgctgcttc     4140

gcgatgtacg ggccagatat acgcgttgac attgattatt gactagttat taatagtaat     4200

caattacggg gtcattagtt catagcccat atatggagtt ccgcgttaca taacttacgg     4260

taaatggccc gcctggctga ccgcccaacg acccccgccc attgacgtca ataatgacgt     4320

atgttcccat agtaacgcca atagggactt tccattgacg tcaatgggtg gagtatttac     4380

ggtaaactgc ccacttggca gtacatcaag tgtatcatat gccaagtacg ccccctattg     4440

acgtcaatga cggtaaatgg cccgcctggc attatgccca gtacatgacc ttatgggact     4500

ttcctacttg gcagtacatc tacgtattag tcatcgctat taccatggtg atgcggtttt     4560

ggcagtacat caatgggcgt ggatagcggt ttgactcacg gggatttcca agtctccacc     4620

ccattgacgt caatgggagt ttgttttggc accaaaatca acgggacttt ccaaaatgtc     4680

gtaacaactc cgccccattg acgcaaatgg gcggtaggcg tgtacggtgg gaggtctata     4740

taagcagagc tctctggcta actagagaac ccactgctta ctggcttatc gaaattaata     4800

cgactcacta tagggagacc caagctagct tggtaccggg ccgacctcac catgggatgg     4860

agctgtatca tcctcttctt ggtagcaaca gctacaggta aggggctcac agtagcaggc     4920

ttgaggtctg gacatatata tgggtgacaa tgacatccac tttgcctttc tctccacagg     4980

tgtgcattcc gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga     5040

aagagtcagt ttctcctgta gggccagtca gttcgttggc tcaagcatcc actggtatca     5100

gcaaagaaca aatggttctc caaggcttct cataaagtat gcttctgagt ctatgtctgg     5160

catccctagc agatttagtg gcagtggatc agggacagat tttactctta gcatcaacac     5220

tgtggagtct gaagatattg cagattatta ctgtcaacaa agtcattcct ggccattcac     5280

gttcggcagc gggacaaatt tggaagtgaa acgtgagtag aacgtacgct agcaagcttg     5340

atatcgaatt ctaaactctg agggggtcgg atgacgtggc cattctttgc ctaaagcatt     5400

gagtttactg caaggtcaga aaagcatgca aagccctcag aatggctgca aagagctcca     5460

acaaaacaat ttagaacttt attaaggaat agggggaagc taggaagaaa ctcaaaacat     5520

caagatttta aatacgcttc ttggtctcct tgctataatt atctgggata agcatgctgt     5580

tttctgtctg tccctaacat gccctgtgat tatccgcaaa caacacaccc aagggcagaa     5640

ctttgttact taaacaccat cctgtttgct tctttcctca ggaactgtgg ctgcaccatc     5700

tgtcttcatc ttcccgccat ctgatgagca gttgaaatct ggaactgcct ctgttgtgtg     5760

cctgctgaat aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct     5820

ccaatcgggt aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag     5880

cctcagcagc accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg     5940

cgaagtcacc catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg     6000

ttagagggag aagtgccccc acctgctcct cagttccagc ctgaccccct cccatccttt     6060

ggcctctgac cctttttcca caggggacct acccctattg cggtcctcca gctcatcttt     6120

cacctcaccc ccctcctcct ccttggcttt aattatgcta atgttggagg agaatgaata     6180

aataaagtga atctttgcac ctgtggtttc tctctttcct catttaataa ttattatctg     6240

ttgttttacc aactactcaa tttctcttat aagggactaa atatgtagtc atcctaaggc     6300

gcataaccat ttataaaaat catccttcat tctattttac cctatcatcc tctgcaagac     6360

agtcctccct caaacccaca agccttctgt cctcacagtc ccctgggcca tggtaggaga     6420

gacttgcttc cttgttttcc cctcctcagc aagccctcat agtccttttt aagggtgaca     6480

ggtcttacag tcatatatcc tttgattcaa ttccctgaga atcaaccaaa gcaaattcct     6540

gcagcccggg ggatccacta gtaacggccg ccagtgtgct ggaattctgc agatatccat     6600

cacactggcg gccgctcgag catgcatcta gagggcccta ttctatagtg tcacctaaat     6660

gctagagctc gctgatcagc ctcgactgtg ccttctagtt gccagccatc tgttgtttgc     6720

ccctcccccg tgccttcctt gaccctggaa ggtgccactc ccactgtcct ttcctaataa     6780

aatgaggaaa ttgcatcgca ttgtctgagt aggtgtcatt ctattctggg gggtggggtg     6840

gggcaggaca gcaaggggga ggattgggaa gacaatagca ggcatgctgg ggatgcggtg     6900

ggctctatgg                                                            6910


<210>  29
<211>  711
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for infliximab light chain optimized for maize.

<400>  29
atgaagtacc tgctgcccac cgctgctgct ggcctgctgc tgctcgctgc ccagcccgct       60

atggccgaca tcctgctgac ccagtccccc gccatcctgt ccgtgtcccc aggcgagcgc      120

gtgtccttct cctgccgcgc ctcccagttc gtgggctcct ccatccactg gtatcagcag      180

cgcaccaacg gctcccccag gctgctgatc aagtacgcct ccgagtccat gtccggcatc      240

ccgtccaggt tctccggctc cggcagcggc accgacttca ccctgtccat caacaccgtg      300

gagtccgagg acatcgccga ctactactgc cagcagtccc actcctggcc cttcaccttc      360

ggctccggca ccaacctcga ggtgaagcgt acggtggctg ccccctccgt gttcatcttc      420

cccccctccg acgagcagct gaagtccggc accgcctccg ttgtctgcct ccttaacaac      480

ttctaccccc gcgaggccaa ggtccagtgg aaggtggaca acgccctcca gtccggcaac      540

tcccaggagt ccgtcaccga gcaggactcc aaggacagca cctactccct gtcctccacc      600

ctgaccctgt ccaaggccga ctacgagaag cacaaggtgt acgcctgcga ggtgacccac      660

cagggcctgt cctcccccgt caccaagtcc ttcaaccgcg gcgagtgctg a               711


<210>  30
<211>  3092
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for SC- and J-chains optimized for HEK.

<400>  30
gcttcgcgat gtacgggcca gatatacgcg ttgacattga ttattgacta gttattaata       60

gtaatcaatt acggggtcat tagttcatag cccatatatg gagttccgcg ttacataact      120

tacggtaaat ggcccgcctg gctgaccgcc caacgacccc cgcccattga cgtcaataat      180

gacgtatgtt cccatagtaa cgccaatagg gactttccat tgacgtcaat gggtggagta      240

tttacggtaa actgcccact tggcagtaca tcaagtgtat catatgccaa gtacgccccc      300

tattgacgtc aatgacggta aatggcccgc ctggcattat gcccagtaca tgaccttatg      360

ggactttcct acttggcagt acatctacgt attagtcatc gctattacca tggtgatgcg      420

gttttggcag tacatcaatg ggcgtggata gcggtttgac tcacggggat ttccaagtct      480

ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa aatcaacggg actttccaaa      540

atgtcgtaac aactccgccc cattgacgca aatgggcggt aggcgtgtac ggtgggaggt      600

ctatataagc agagctctct ggctaactag agaacccact gcttactggc ttatcgaaat      660

taatacgact cactataggg agacccaagc tagcttggta ccgggccgac ctcaccatga      720

agaaccacct gctgttctgg ggcgtgctgg ccgtgttcat caaggccgtg cacgtgaagg      780

ctcaggagga tgagcgcatc gtcctcgtgg acaacaagtg caagtgcgcc cgcatcacct      840

cccgcatcat ccgctcctcc gaggacccca acgaggacat cgtggagcgc aacatccgca      900

tcatcgtgcc cctgaacaac cgcgagaaca tctccgaccc cacctccccc ctgaggaccc      960

gcttcgtgta ccacctgtcc gacctgtgca agaagtgcga ccccaccgag gtggagctgg     1020

acaaccagat cgtgaccgcc acccagtcca acatctgcga cgaggactcc gccaccgaga     1080

cctgctacac ctacgaccgc aacaagtgct acaccgccgt ggtgcccctg gtgtacggcg     1140

gcgagaccaa gatggtggag accgccctga cccccgacgc ttgctacccc gactgataat     1200

ctagaggatc tcccgatccc ctatggtgca ctctcagtac aatctgctct gatgccgcat     1260

agttaagcca gtatctgctc cctgcttgtg tgttggaggt cgctgagtag tgcgcgagca     1320

aaatttaagc tacaacaagg caaggcttga ccgacaatta attgcatgaa gaatctgctt     1380

agggttaggc gttttgcgct gcttcgcgat gtacgggcca gatatacgcg ttgacattga     1440

ttattgacta gttattaata gtaatcaatt acggggtcat tagttcatag cccatatatg     1500

gagttccgcg ttacataact tacggtaaat ggcccgcctg gctgaccgcc caacgacccc     1560

cgcccattga cgtcaataat gacgtatgtt cccatagtaa cgccaatagg gactttccat     1620

tgacgtcaat gggtggagta tttacggtaa actgcccact tggcagtaca tcaagtgtat     1680

catatgccaa gtacgccccc tattgacgtc aatgacggta aatggcccgc ctggcattat     1740

gcccagtaca tgaccttatg ggactttcct acttggcagt acatctacgt attagtcatc     1800

gctattacca tggtgatgcg gttttggcag tacatcaatg ggcgtggata gcggtttgac     1860

tcacggggat ttccaagtct ccaccccatt gacgtcaatg ggagtttgtt ttggcaccaa     1920

aatcaacggg actttccaaa atgtcgtaac aactccgccc cattgacgca aatgggcggt     1980

aggcgtgtac ggtgggaggt ctatataagc agagctctct ggctaactag agaacccact     2040

gcttactggc ttatcgaaat taatacgact cactataggg agacccaagc tagcttggta     2100

ccgggccgac ctcaccatga agtacctgct gcccaccgct gctgctggcc tgctgctgct     2160

cgctgcccag cccgctatgg ccgacatcct gctgacccag tcccccgcca tcctgtccgt     2220

gtccccaggc gagcgcgtgt ccttctcctg ccgcgcctcc cagttcgtgg gctcctccat     2280

ccactggtat cagcagcgca ccaacggctc ccccaggctg ctgatcaagt acgcctccga     2340

gtccatgtcc ggcatcccgt ccaggttctc cggctccggc agcggcaccg acttcaccct     2400

gtccatcaac accgtggagt ccgaggacat cgccgactac tactgccagc agtcccactc     2460

ctggcccttc accttcggct ccggcaccaa cctcgaggtg aagcgtacgg tggctgcccc     2520

ctccgtgttc atcttccccc cctccgacga gcagctgaag tccggcaccg cctccgttgt     2580

ctgcctcctt aacaacttct acccccgcga ggccaaggtc cagtggaagg tggacaacgc     2640

cctccagtcc ggcaactccc aggagtccgt caccgagcag gactccaagg acagcaccta     2700

ctccctgtcc tccaccctga ccctgtccaa ggccgactac gagaagcaca aggtgtacgc     2760

ctgcgaggtg acccaccagg gcctgtcctc ccccgtcacc aagtccttca accgcggcga     2820

gtgctgataa tctagagggc ccgtttaaac ccgctgatca gcctcgactg tgccttctag     2880

ttgccagcca tctgttgttt gcccctcccc cgtgccttcc ttgaccctgg aaggtgccac     2940

tcccactgtc ctttcctaat aaaatgagga aattgcatcg cattgtctga gtaggtgtca     3000

ttctattctg gggggtgggg tggggcagga cagcaagggg gaggattggg aagacaatag     3060

caggcatgct ggggatgcgg tgggctctat gg                                   3092


<210>  31
<211>  1515
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for adalimumab heavy chain IgA1 optimized for Lemna.

<400>  31
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcgaggtcc agctggtgga gtccggcggg      120

ggcctggtcc agcccgggcg ctccctgcgc ctcagctgcg cggccagcgg cttcaccttc      180

gacgattacg ccatgcactg ggtcagacag gccccgggga agggcctcga gtgggtgtcc      240

gccatcactt ggaacagcgg ccacatcgac tacgccgact ccgtggaggg gcggttcacg      300

atcagccggg acaacgccaa gaactccctg tacctgcaga tgaactccct cagagcggag      360

gacactgcgg tctactattg cgccaaggtg agctacctga gcaccgcgtc cagcttggac      420

tactgggggc agggcaccct ggtgacggtg tcctcagcct cgcccacgtc gccgaaggtc      480

ttccccctca gcctctgctc gacgcagccc gacgggaacg ttgtcatcgc ctgcctcgtg      540

cagggcttct tcccgcagga gccgctctcc gtgacctggt ccgagagcgg ccagggcgtt      600

accgctcgga acttcccgcc ctcccaggac gcgagcggcg atctctacac tacgtcctcg      660

cagcttacgc tcccggcgac gcaatgcctc gccggcaaga gcgtgacgtg ccacgtcaag      720

cactacacca atccctcgca ggacgtgacc gtgccctgcc cggtgccttc cacgcctccg      780

acgccgagcc cgtccacgcc gccgacccct tcgcccagct gctgtcaccc gcgcctctcc      840

ctccaccggc ccgccctgga ggacctgttg ctcgggagcg aggcgaacct cacctgcacg      900

ctcacgggcc tgcgcgacgc ctctggcgtt accttcacct ggacgccctc ttccgggaag      960

agcgccgtgc agggcccgcc cgagagagac ctctgcggtt gctactccgt gtcgagcgtg     1020

ctcccggggt gcgcggagcc gtggaaccac gggaagacct tcacctgcac cgcggcctac     1080

cctgagtcca agacgcccct gaccgccacc ctgtccaagt ccgggaacac cttccgcccg     1140

gaggtgcact tgctgccacc gcccagcgag gaactcgccc tgaacgagct ggtcacgctc     1200

acctgcctgg ctaggggctt ctcgcccaag gacgtgctgg tccgctggtt gcaaggcagc     1260

caggagctgc cgcgcgagaa gtacctcacc tgggcctcta ggcaggagcc ctcgcagggc     1320

accactacgt tcgcggtgac ctccatcctc agggtcgccg ctgaggactg gaagaaaggc     1380

gacaccttct cctgcatggt cggccacgag gcgctgcccc tcgccttcac ccagaagacc     1440

atcgaccggc tggccgggaa gcccacccac gtcaacgtca gcgtcgttat ggctgaggtt     1500

gacgggacgt gctac                                                      1515


<210>  32
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for adalimumab light chain kappa optimized for 
       Lemna.

<400>  32
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcgacatcc agatgacgca gagcccgtcg      120

agcctgtccg cctccgtcgg ggacagggtc acgatcacct gcagagccag ccagggcatc      180

cgcaactacc tggcctggta tcaacagaag cccgggaagg ctccgaagct cctgatctac      240

gcggccagca ccctccagag cggcgtcccg agccggttct ccggcagcgg ctccggcacc      300

gacttcaccc tcaccatcag ctcgctccag cccgaggacg tcgccaccta ctactgccag      360

aggtacaacc gcgcgccgta cacgttcggg cagggcacga aggtggagat caagcgcacg      420

gtggccgcgc ccagcgtctt catcttcccg ccctcggacg agcagctgaa gtccggcact      480

gcctccgtgg tctgcctgct caacaacttc tacccccgcg aagccaaggt gcagtggaag      540

gttgacaacg cgctccagag cgggaactcc caggagtccg tgaccgagca ggactccaag      600

gactccacct acagcctgtc cagcaccctc accctctcca aggccgacta cgagaagcac      660

aaggtgtacg cctgcgaggt gacccaccag ggcctctcct ccccggtgac caagtccttc      720

aaccgcggtg agtgc                                                       735


<210>  33
<211>  480
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for J-chain optimized for maize.

<400>  33
atgaagaacc acctgctgtt ctggggcgtg ctggccgtgt tcatcaaggc cgtgcacgtg       60

aaggctcagg aggatgagcg catcgtcctc gtggacaaca agtgcaagtg cgcccgcatc      120

acctcccgca tcatccgctc ctccgaggac cccaacgagg acatcgtgga gcgcaacatc      180

cgcatcatcg tgcccctgaa caaccgcgag aacatctccg accccacctc ccccctgagg      240

acccgcttcg tgtaccacct gtccgacctg tgcaagaagt gcgaccccac cgaggtggag      300

ctggacaacc agatcgtgac cgccacccag tccaacatct gcgacgagga ctccgccacc      360

gagacctgct acacctacga ccgcaacaag tgctacaccg ccgtggtgcc cctggtgtac      420

ggcggcgaga ccaagatggt ggagaccgcc ctgacccccg acgcttgcta ccccgactga      480


<210>  34
<211>  504
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for J-chain optimized for Lemna.

<400>  34
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggccaggagg acgagcgcat cgtcctcgtg      120

gacaacaagt gcaagtgcgc gcgcatcacc agccgcatca tccggtccag cgaggacccc      180

aacgaggaca tcgtcgagcg caacatccgc atcatcgtgc ccctgaacaa ccgcgagaac      240

atctccgacc cgacctcccc gctgaggacc cgcttcgtgt accacctgag cgacctctgc      300

aagaagtgcg accccaccga ggtggaactc gacaaccaga tcgtcacggc cacccagagc      360

aacatctgcg acgaggactc cgccaccgag acgtgctaca cctacgacag gaacaagtgc      420

tacacggccg tcgtgcccct cgtgtacggc ggggagacca agatggtcga gacggccctg      480

accccggacg cgtgctaccc cgac                                             504


<210>  35
<211>  1818
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for SC-chain optimized for maize.

<400>  35
atggctatgc tgctgttcgt gctgacctgc ctgctggccg tgttccccgc catctccacc       60

aagtccccca tcttcggccc cgaggaggtg aactccgtgg agggcaactc cgtgtccatc      120

acctgctact acccccccac ctccgtgaac cgccacacta ggaagtactg gtgcaggcag      180

ggcgctaggg gcggctgcat caccctgatc tcctccgagg gctacgtttc tagcaagtac      240

gctggcaggg ccaacctgac caacttcccc gagaacggca ccttcgtggt gaacatcgcc      300

cagctgtccc aggacgactc cggccgctac aagtgcggcc tgggcatcaa ctccaggggc      360

ctgtccttcg acgtgtccct cgaggtgtcc cagggcccag gcctgctgaa cgacaccaag      420

gtgtacaccg tggacctcgg tcgcaccgtc accatcaact gccccttcaa gaccgagaac      480

gcccagaagc gcaagtccct gtacaagcag atcggcctgt accccgtgct ggtgatcgac      540

tcctccggct acgtgaaccc caactacacc ggccgcatcc gcctggacat ccagggcact      600

ggccagctgc tgttctccgt ggtgatcaac cagctgcgcc tgtccgatgc tggccaatac      660

ctgtgccaag ctggcgacga ctccaactcc aacaagaaga acgccgacct ccaggtgctg      720

aagcccgagc ccgagctggt gtacgaggac ctgcgcggct ccgtgacctt ccactgcgct      780

ctgggccccg aggtggcgaa cgttgcgaag ttcctctgca ggcagtcctc cggcgagaac      840

tgcgacgtgg tggtgaacac cctgggcaag cgcgctcccg ctttcgaggg ccgcatcctg      900

ctgaaccccc aggacaagga cggctccttc tccgtcgtca tcaccggcct gcgcaaggag      960

gacgctggcc gctacctctg cggcgctcac tccgacggcc agctccagga gggctccccc     1020

atccaggcct ggcagctgtt cgtgaacgag gagtccacca tccccaggtc ccccaccgtg     1080

gtgaagggcg tggctggcgg ctccgtggct gtgctgtgcc cctacaaccg caaggagtcc     1140

aagtccatca agtactggtg cctgtgggag ggcgctcaga acggcaggtg ccccctgctc     1200

gtggactccg agggctgggt gaaggcccag tacgagggca ggctgtccct gctcgaggag     1260

cccggcaacg gcaccttcac cgtgatcctg aaccagctga cctcccgcga cgccggcttc     1320

tactggtgcc tcaccaacgg cgacaccctg tggaggacca ccgtggagat caagatcatc     1380

gagggcgagc ccaacctgaa ggtcccaggg aacgtgaccg ctgtgctggg cgagaccctg     1440

aaggtcccct gccacttccc ctgcaagttc tcctcctacg agaagtactg gtgcaagtgg     1500

aacaacaccg gctgccaggc tctgccctcc caggacgagg gcccctccaa ggccttcgtg     1560

aactgcgacg agaactcccg cctggtgtcc ctgaccctga acctggtgac cagggccgac     1620

gagggctggt actggtgcgg cgtgaagcag ggccacttct acggcgagac cgccgctgtg     1680

tacgtggccg tggaggagag gaaggccgct ggctctaggg atgtttctct tgccaaggct     1740

gacgctgccc ccgacgagaa ggtgctggac tccggcttcc gcgagatcga gaacaaggcc     1800

atccaggacc cccgctga                                                   1818


<210>  36
<211>  1848
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA sequence for SC-chain optimized for Lemna.

<400>  36
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcaagtccc cgatcttcgg gccggaggaa      120

gtgaactcgg tggaggggaa ctccgtcagc atcacctgct actatcctcc gacgagcgtg      180

aaccggcaca cgaggaagta ctggtgcagg caaggggcca gaggcgggtg catcaccctc      240

atctccagcg aggggtacgt ctcgtccaag tacgccggtc gcgccaacct cacgaacttc      300

cccgagaacg ggacgttcgt tgtgaacatc gcccagctgt cgcaggacga cagcggccgc      360

tacaagtgtg gcctcgggat caacagccgc gggctctcct tcgacgtctc gctggaggtg      420

tcccagggcc ccggcctcct gaacgacacg aaagtgtaca ccgttgacct cggccggacg      480

gtcactatca actgcccgtt caagaccgag aacgcccaga agcgcaagag cctctacaag      540

cagatcggcc tctacccggt cctggtgatc gactcctcgg gctacgtcaa cccgaactac      600

accggccgca tccggctgga catccagggg accgggcagc tgctcttctc cgtggtcatc      660

aaccagctcc gcctgagcga cgccgggcag tacctgtgcc aggccgggga cgatagcaac      720

tccaacaaga agaacgccga cctccaagtg ctgaagcccg agccggagct ggtctacgag      780

gacctccgcg ggtccgtgac cttccactgc gccctgggcc cggaggtcgc caacgtggcg      840

aagttcctgt gccggcagtc ctcgggtgag aactgcgacg tggtcgtgaa caccctcggg      900

aagcgcgcgc ccgccttcga gggccgcatc ctgctcaatc cccaggacaa ggacgggtcc      960

ttcagcgtgg tcatcacggg cctccgcaag gaagacgcgg gccgctacct ctgcggcgcc     1020

cactcggacg gccagctcca ggaggggagc cccatccagg cctggcagct gttcgtcaac     1080

gaggagtcca cgatccccag aagccccacc gtggttaagg gcgtcgccgg tggctccgtg     1140

gcggtgctgt gcccgtacaa ccgcaaggag agcaagtcca tcaagtactg gtgcctgtgg     1200

gagggcgccc agaacgggag atgcccgctc ctggtggact ccgaggggtg ggtgaaggcg     1260

cagtacgagg gccgcctctc gctcctggag gagcccggca acggcacctt caccgtcatc     1320

ctcaaccagc tgacgtcgcg ggacgccggc ttctactggt gcctcaccaa cggcgacacc     1380

ctctggagga ccacggtgga gatcaagatc atcgagggcg agccgaacct gaaagtccct     1440

gggaacgtga ccgctgtcct cggcgagacc ctgaaggtgc cctgccactt cccctgcaag     1500

ttctccagct acgagaagta ctggtgcaag tggaacaaca ccggctgtca ggccctcccc     1560

tcgcaggacg aggggccgtc caaggcgttc gtgaactgcg acgagaacag ccgcctcgtg     1620

tccctcaccc tcaacctcgt gacccgcgcc gacgagggct ggtactggtg cggggtgaag     1680

cagggccact tctacgggga gaccgccgcg gtctacgtgg cggtcgagga gcgcaaggcc     1740

gctggctccc gcgacgtcag cctggccaag gccgacgccg cgcccgacga gaaggtgctg     1800

gactccgggt tccgggagat cgagaacaag gccatccagg atccccgg                  1848


<210>  37
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       ustekinumab (CTNO-1275).

<400>  37

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Tyr Ser Phe Thr Thr Tyr 
            20                  25                  30          


Trp Leu Gly Trp Val Arg Gln Met Pro Gly Lys Gly Leu Asp Trp Ile 
        35                  40                  45              


Gly Ile Met Ser Pro Val Asp Ser Asp Ile Arg Tyr Ser Pro Ser Phe 
    50                  55                  60                  


Gln Gly Gln Val Thr Met Ser Val Asp Lys Ser Ile Thr Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Asn Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Arg Pro Gly Gln Gly Tyr Phe Asp Phe Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  38
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       ustekinumab (CTNO-1275).

<400>  38

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Trp 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Glu Lys Ala Pro Lys Ser Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ile Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  39
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the heavy chain variable region of 
       briakinumab (CJ-695, ABT-874).

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Phe Ile Arg Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Lys Thr His Gly Ser His Asp Asn Trp Gly Gln Gly Thr Met Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  40
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino acid sequence of the light chain variable region of 
       briakinumab (J-695, ABT-874).

<400>  40

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Lys Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Tyr Asn Asp Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Arg Tyr Thr 
                85                  90                  95      


His Pro Ala Leu Leu Phe Gly Thr Gly Thr Lys Val Thr Val Leu Gly 
            100                 105                 110         


<210>  41
<211>  1509
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lemna-optimized complete SILA heavy chain IgA1 DNA (including 
       signal peptide SEQ ID NO:26).

<400>  41
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcgaggtcc agctggtgca gtccggcgcg      120

gaggtcaaga agcctgggga atccctgaag atcagctgca agggcagcgg gtacagcttc      180

accacttact ggctcggctg ggtgcgccag atgccgggca aggggctgga ctggatcggg      240

atcatgtccc ccgtggactc cgacatccgg tactccccga gcttccaggg ccaggtcact      300

atgtccgtgg acaagagcat caccacggcc tacttgcagt ggaactccct gaaggcgagc      360

gataccgcga tgtactattg cgcgagacgg agacccgggc agggctactt cgacttctgg      420

gggcagggca ccctggtgac ggtgtcctca gcctcgccca cgtcgccgaa ggtcttcccc      480

ctcagcctct gctcgacgca gcccgacggg aacgttgtca tcgcctgcct cgtgcagggc      540

ttcttcccgc aggagccgct ctccgtgacc tggtccgaga gcggccaggg cgttaccgct      600

cggaacttcc cgccctccca ggacgcgagc ggcgatctct acactacgtc ctcgcagctt      660

acgctcccgg cgacgcaatg cctcgccggc aagagcgtga cgtgccacgt caagcactac      720

accaatccct cgcaggacgt gaccgtgccc tgcccggtgc cttccacgcc tccgacgccg      780

agcccgtcca cgccgccgac cccttcgccc agctgctgtc acccgcgcct ctccctccac      840

cggcccgccc tggaggacct gttgctcggg agcgaggcga acctcacctg cacgctcacg      900

ggcctgcgcg acgcctctgg cgttaccttc acctggacgc cctcttccgg gaagagcgcc      960

gtgcagggcc cgcccgagag agacctctgc ggttgctact ccgtgtcgag cgtgctcccg     1020

gggtgcgcgg agccgtggaa ccacgggaag accttcacct gcaccgcggc ctaccctgag     1080

tccaagacgc ccctgaccgc caccctgtcc aagtccggga acaccttccg cccggaggtg     1140

cacttgctgc caccgcccag cgaggaactc gccctgaacg agctggtcac gctcacctgc     1200

ctggctaggg gcttctcgcc caaggacgtg ctggtccgct ggttgcaagg cagccaggag     1260

ctgccgcgcg agaagtacct cacctgggcc tctaggcagg agccctcgca gggcaccact     1320

acgttcgcgg tgacctccat cctcagggtc gccgctgagg actggaagaa aggcgacacc     1380

ttctcctgca tggtcggcca cgaggcgctg cccctcgcct tcacccagaa gaccatcgac     1440

cggctggccg ggaagcccac ccacgtcaac gtcagcgtcg ttatggctga ggttgacggg     1500

acgtgctac                                                             1509


<210>  42
<211>  735
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Lemna-optimized complete SILA light chain DNA (including signal 
       peptide SEQ ID NO:26).

<400>  42
atgcaggtcc tgaacacgat ggtcaacaag cacttcctct ccctgtccgt cctcatcgtc       60

ctcctcgggc tgagcagcaa cctcaccgcc ggcgacatcc agatgacgca gagcccgtcg      120

agcctgtccg cctccgtcgg ggacagggtc acgatcacct gcagagccag ccagggcatc      180

tcgtcctggc tggcctggta tcaacagaag cccgagaagg ctccgaagtc cctgatctac      240

gcggccagct ccctccagag cggcgtcccg agccggttct ccggcagcgg ctccggcacc      300

gacttcaccc tcaccatcag ctcgctccag cccgaggact tcgccaccta ctactgccag      360

cagtacaaca tctacccgta cacgttcggg cagggcacga agctggagat caagcgcacg      420

gtggccgcgc ccagcgtctt catcttcccg ccctcggacg agcagctgaa gtccggcact      480

gcctccgtgg tctgcctgct caacaacttc tacccccgcg aagccaaggt gcagtggaag      540

gttgacaacg cgctccagag cgggaactcc caggagtccg tgaccgagca ggactccaag      600

gactccacct acagcctgtc cagcaccctc accctctcca aggccgacta cgagaagcac      660

aaggtgtacg cctgcgaggt gacccaccag ggcctctcct ccccggtgac caagtccttc      720

aaccgcggtg agtgc                                                       735


