                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR
 
<120>  NEW EFFICIENT INTERFERON-BASED TREATING METHODS

<130>  362041D30473

<150>  US 61/569,648
<151>  2011-12-12

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  2803
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  DNA of human IL28A (promoter + gene)

<400>  1
tggtggcaca aatctgtaat ctcagctact tgggaggcta aggcaagaga atcgcttgaa       60

cccaggaggt ggaggttgca gttagtcaag attttgcact gcactccagc ctgggtgacc      120

gaacaagacc ctgtctcaaa atatatatat atatatatgc caggaggggt ggctcaggcc      180

tgtaatctca gcactttaat aggctgggtg aggaggatgg cttgagccca ggagtttgag      240

gctgcagtga gctgtgatca tgccattgca ctccagtgac agagtgagac cctgtcttaa      300

acaacaacaa aaccagagca ggtggaatcc tcctgggaac ataccttcct gtaggttacc      360

cctgagtctc catcagtttc tctttccctc cagctgctca tctggctcac tagccctgcc      420

ctgctctggg ctttcccagc ctggggctcc cctggtggcc ggtgtcttac ctgaggctgt      480

gttttcactt ttcctacatc agctgggact gcccttctgt cagggataaa agctgcccca      540

tggagctcag gcaggaatta catcccagac agagctcaaa actgacagaa agagtcaaag      600

ccaggacaca gtctgagatc cagaagaggg gactgaaaag aacagagact ccagacaaga      660

cccaaacaga ccctgggtga cagcctcaga gtgtttcttc tgctgacaaa gaccagagat      720

caggaatgaa actaggtgag tcccacatct ctgtccgtgc tcagctcctg cagcccctgc      780

cctcagtggg cagcctctcc atcccctcag ctccctttct ctctgtgaca cagacatgac      840

tggggactgc acgccagtgc tggtgctgat ggccgcagtg ctgaccgtga ctggagcagt      900

tcctgtcgcc aggctccacg gggctctccc ggatgcaagg ggctgccaca tagcccagtt      960

caagtccctg tctccacagg agctgcaggc ctttaagagg gccaaagatg ccttagtgag     1020

tctccccctg ccctcctgcc atggactagc ctccaccccc actccaagcg tcaccatgct     1080

ttcccactcc cagcttcctt cactgggcta gcctccaccc tccctgcagt gggctatctc     1140

atgctcctac tgtagggact gactcatgtt ttcctgtaga agagggtcct ctaccatcct     1200

cccagcagtt aacctcccct atcctgttgt cagccatcct ccaatcccac caggatggtc     1260

taacctccac ccctcctgct ggggctaacc tgtgcctttg ctgtctagga agagtcgctt     1320

ctgctgaagg actgcaggtg ccactcccgc ctcttcccca ggacctggga cctgaggcag     1380

ctgcaggtga gagggggagt caggcccacc cctgctctcc cagccccact cacctggctc     1440

tgtagtggcc ccttcaccgt ctctttctcc cttgtctctc tctcttctcc tcacacctgc     1500

tctcccttcc ctccgctccc acctgaccac actggctgtg ccctctcccc tgtgcctgtc     1560

accttcactt gttcctctct atcctgctcc ccaacctgtt cccctcacct cccccctcac     1620

ctgctctttc tcacctctcc tcaggtgagg gagcgcccca tggctttgga ggctgagctg     1680

gccctgacgc tgaaggttct ggaggccacc gctgacactg acccagccct ggtggacgtc     1740

ttggaccagc cccttcacac cctgcaccat atcctctccc agttccgggc ctgtgtgagt     1800

cgttggggcc tgggcaccca ggtctgtgag ctctgagcag cgtccttccc cttgccaagg     1860

ccccggctca cacaccgccc tcctctgccc acagatccag cctcagccca cggcagggcc     1920

caggacccgg ggccgcctcc accattggct gtaccggctc caggaggccc caaaaaaggt     1980

gagtgacccg ggaagagagg gactgaggtc tggggagcca ctgggagccc agaacccaga     2040

cagcccctga cccatcccct cctccctaca ggagtcccct ggctgcctcg aggcctctgt     2100

caccttcaac ctcttccgcc tcctcacgcg agacctgaat tgtgttgcca gtggggacct     2160

gtgtgtctga ccctcccacc agtcatgcaa cctgagattt tatttataaa ttagccactt     2220

gtcttaattt attgccaccc agtcgctatt tatgtatttg tgtgtgtaaa tccaactcac     2280

ctccaggaaa atgtttattt ttctactttt tataaccctt gttgaaataa acaaaggaaa     2340

agacactcat gacgttggac tgtgtgtctg ttggtgtgta tttcctttgt gttgctgcca     2400

taacaacgct aaaagtagca tcttccaaag acacacttga tgagctggga gtctgcaggt     2460

cagaggctcg ctggccctgg ctggtttctc tcctgtggga ctcacaggct agaatccaag     2520

cattgctgct gggctcttac tgggagctct gaagagaaac tctttccagg gtcagtcaca     2580

ttgttggcag atcactgttc cttgctgctg taggactaag gttcctgccc cctcctggct     2640

atgggtccat cctgagctga ctctgctgaa gggttctcca ctcctctcac taagctaacc     2700

tctaccctcc ctgcagtggg ctatctcatg ctcctactat aggggctgat tcatgtcctc     2760

ctgcagtgga gggtcctgta acatcctccc gggagttaac ctc                       2803


<210>  2
<211>  200
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Amino acid sequence of IL28A containing 112T and 160Y

<400>  2

Met Lys Leu Asp Met Thr Gly Asp Cys Thr Pro Val Leu Val Leu Met 
1               5                   10                  15      


Ala Ala Val Leu Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu His 
            20                  25                  30          


Gly Ala Leu Pro Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser 
        35                  40                  45              


Leu Ser Pro Gln Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu 
    50                  55                  60                  


Glu Glu Ser Leu Leu Leu Lys Asp Cys Arg Cys His Ser Arg Leu Phe 
65                  70                  75                  80  


Pro Arg Thr Trp Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Met 
                85                  90                  95      


Ala Leu Glu Ala Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr 
            100                 105                 110         


Ala Asp Thr Asp Pro Ala Leu Val Asp Val Leu Asp Gln Pro Leu His 
        115                 120                 125             


Thr Leu His His Ile Leu Ser Gln Phe Arg Ala Cys Ile Gln Pro Gln 
    130                 135                 140                 


Pro Thr Ala Gly Pro Arg Thr Arg Gly Arg Leu His His Trp Leu Tyr 
145                 150                 155                 160 


Arg Leu Gln Glu Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala 
                165                 170                 175     


Ser Val Thr Phe Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys 
            180                 185                 190         


Val Ala Ser Gly Asp Leu Cys Val 
        195                 200 


<210>  3
<211>  5132
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  DNA of human IL28B (promoter + gene)

<400>  3
aggccccccg gcgctgcctg ctctcgcact accgctcgct ggagccccgg acgctggcgg       60

ctgccaaggc gctgagggac cgctacgtaa gtcaccgccc agcccctgtg ccccctggga      120

ccctggcccc accgggttcc catacacccg ttcctgtccc aaggggtcct gcgtcctagc      180

gcccagcagg cgcctctcct atgtcagcgc ccacaattcc caccacgaga cccccgcagt      240

ccccgtcgtc agcgcgaacg caggctcagg gtcaatcaca gaagggagcc ctgccgggag      300

gactcggctc caggtcgggg cgaggggctt tgctggggga gcgcggagtg caattcaacc      360

ctggttcgcg ccttcgggga gctccctggt tcagtacacg acaggcacga ccgtgcgctg      420

ccagtaccca tccacgtcca ggaatcccag actgtgcaga ggttaggggc cctggcgagg      480

gggcctagcc gtatgcgata agcgccgctt gtcccgcagg aggaagaggc gctgagctgg      540

gggcagcgca actgctcctt ccgccccagg agggatcctc cgcggccatc ggtgaggccc      600

gggagtgggc gggagaggca tggcccgggc gcggcccgct ctaacgccct ctcgtccccg      660

cagtcctgcg ctcggctccg ccacgtggcc cggggcatcg cggacgccca ggcagtgctc      720

agcggcctgc accgctcgga gctgctcccc ggcgccggcc cgatcctgga gctgctggcg      780

gccgcgggga gggatgtggc ggcctgcgtg agtgacggcc gcgccccgcc gcccctctcc      840

cccgccagct tctctgcatc ctcaggccca cggcgagccc cagcgctttg ccaatctgtc      900

ctgcttagcg gaaaaaccca tccagaccgg agtcgggtcc tctgggtgtc ctgaaatccg      960

ggctcgagtc tgcggctggg agggccacgg gcagatgcag agaggggctt cgtccttcgc     1020

cttttccatt tgcctcatgt cccacctcca gcttgagctg gcacggccag gctcctccag     1080

gaaggtcccc ggggcccaga agaggcgtca caaaccccgg agagcggtga gtgcaacagg     1140

caatacaggg ttagcccgca gggaggacca ggcgaggctg acaaggacgg gactgaggct     1200

gcgagcagcg ggactggagg gggattccgg gggcgggggg aagagcctgg cttagccccg     1260

ctgccctccc tccctggctc caggactcgc ctcggtgccg caaagccagc gtggtcttca     1320

acctcctgcg cctgctcacg tgggagctcc ggctggctgc acactctggg ccttgcctct     1380

gaccccgccc cctctggcag cacggaaacc tccacgccat tggctgccga aagcagctcc     1440

tgtcgtccat tgggctggcc gggcgaggct ctcagtcaat gggtgctgag gcacgaaaac     1500

ttcttcgcag ccttgggcct gacttggatc cactgtctca gatataagag gagcgggtcc     1560

ttctacaggg aagagaccac agttctccag gaagccacga tatttcctcg gggtgcattg     1620

tacgaccctc caacggttgc tgtggcagga aaaaacttga gctctggaaa ccgtggctga     1680

ccccaggcaa cagggaccag ttcctccttg tgtggttacc aggacacccc caacaccagg     1740

tcctaacccc ggatttgtag ccccacagcc agctttgaga ttctgtgaat ccgtgactct     1800

tggatccggc atctaaggga caccaatcca tgagggattt ggtagtgaaa ggcccaaggg     1860

tccttaaccg actgtggttc tttggattcc cttacgtgtg tttgtatttg tgaagttcct     1920

gtgcatttgc tattctgtct cccggtttaa atttattgcc agttatcaaa gagtgttttg     1980

atcgcattgg ttgttttccg tatgatgatt gtgaggtgca ccttacagca aaaaaagagg     2040

ccgagccagg gactcaggtg gcctgagttt cagttctgac cctgccagtt aattacagtg     2100

gaattcaggg caaattactt ttctgagcct ctgtttcctc acctatagga tgggttagca     2160

tacttgcctt gtggaggagt agtgtccgtt gagatcacgt tttaaactct ccagctgagg     2220

tcctagtatg gtcttaatga gtggattcta ttaaataatc actcacataa atacacaaac     2280

aattgtgtta ttaatttttt ctccaaatct gtgcattagc aatctgcgtt gctgaatgca     2340

cccctccttg ccaaggtcac acggctagtg agggtcagaa ccaggtttga accccagacc     2400

cttcatctcc aagacccatg ctcttcacca ctgcctgaac ttccctaaga aagacggcac     2460

ccacgtggtg tccttcaagt ccttcgtcac acctcaattc ttgagcagag cctcatattc     2520

ctgagtcctt ccttgcctgg gcaattaaga aatattggcc tctgggcatg gtggctcaca     2580

ctgaaatccc agcaatttgg gaggcctaga cagagagatg acttgacatc aggaatttga     2640

gaccagcctt gccaacatgg tgaaacgcca tctctactaa aaatataaaa attagctggg     2700

aatggtggca caaatctgta atctcagcta cttgggaggc taaggcaaga gaattgcttg     2760

aacccaggag gcggaggttg cagttagcca agattttgca ctgcactcca gcctgggtga     2820

ccgaacaaga ccctgtctca aaatatatat atatatatat atatatatat gccaggagtg     2880

gtggctcagg cctgtaatct cagcacttta ataggctggg tgaggaggat ggcttgagcc     2940

caggagtttg aggctgcagt gagctgtgat catgccattg cactgcagtg acagagtgag     3000

accctgtctt aaacaacaac aaaaccagag caggtggaat cctcttggga acataccttc     3060

ctgtaggtta cccctgagtc tccatcagtt tctctttccc tccagctgct catctggctc     3120

actagccctg ccctgctctg ggctttccca gcctggggct cccctggtgg ccggtgtctt     3180

acctgaggct gtgttttcac ttttcctaca tcagctggga ctgcccttct gtcagggata     3240

aaagctgccc catggagctc aggcaggaat tacatcccag acagagctca aaactgacag     3300

aaagagtcaa agccaggaca cagtctgaga tccagaagag gggactgaaa agaacagaga     3360

ctccagacaa gacccaaaca gaccctgggt gacagcctca gagtgtttct tctgctgaca     3420

aagaccagag atcaggaatg aaactaggtg agtcccacat ctctgtccgt gctcagctcc     3480

tgcagcccct gccctcagtg ggcagcctct gcattccctc agctcccttt ctctctgtga     3540

cacagacatg accggggact gcatgccagt gctggtgctg atggccgcag tgctgaccgt     3600

gactggagca gttcctgtcg ccaggctccg cggggctctc ccggatgcaa ggggctgcca     3660

catagcccag ttcaagtccc tgtctccaca ggagctgcag gcctttaaga gggccaaaga     3720

tgccttagtg agtctccccc tgccctcctg ccatggacta gcctccaccc gcactccaag     3780

ggtcaccatg ctttcccact cccagcttcc ttcactgggc tagcctccac cctccctgca     3840

gtgggctatc tcatgctcct actgcaggga ctgactcatg ttttcctgaa gaagagggtc     3900

ctctaccatc ctcccagcag ttaacctccc ctatcctgtt gtcagccatc ctccaatccc     3960

atcagagtgg tctaacctcc acccctcctg ctggggctaa cctgtgcctt tgctgtctag     4020

gaagagtcgc ttctgctgaa ggactgcaag tgccgctccc gcctcttccc caggacctgg     4080

gacctgaggc agctgcaggt gagaggggga gtcaggccca cccctgccct cccagccctg     4140

ctcacctggc tctgtagtgg ccccttcacc ttctccttct ccattgtccc tctctcctct     4200

ccccacacct gctacccctt ccctctgctc ctacctgacc acactggctg tgccctctcc     4260

cctgtgcctg tcaccttcac ttgttcctct ctatcctcct cccccaacct gttcccctca     4320

cctcccccct cacctgctct ttctcacctc tcctcaggtg agggagcgcc ccgtggcttt     4380

ggaggctgag ctggccctga cgctgaaggt tctggaggcc accgctgaca ctgacccagc     4440

cctgggggat gtcttggacc agccccttca caccctgcac catatcctct cccagctccg     4500

ggcctgtgtg agtcgtcagg gcccgggcac ccaggtctgt gagctctgag cagcgtcctt     4560

cccctggcca aggccccggc tcacacaccg ccctcctctg cccacagatc cagcctcagc     4620

ccacggcagg gcccaggacc cggggccgcc tccaccattg gctgcaccgg ctccaggagg     4680

ccccaaaaaa ggtgagtgac ccgggaagag agggactgag gtctggggag ccactgggag     4740

cccagaaccc agacagcccc tgacccatcc cctcctccct acaggagtcc cctggctgcc     4800

tcgaggcctc tgtcaccttc aacctcttcc gcctcctcac gcgagacctg aattgtgttg     4860

ccagcgggga cctgtgtgtc tgacccttcc gccagtcatg caacctgaga ttttatttat     4920

aaattagcca cttggcttaa tttattgtca cccagtcgct atttatgtat ttgtgtatgt     4980

aaatccaact cacctccagg aaaatgttta tttttctact ttttgaaatc cttgttgaaa     5040

taaacaatga ggaaaagaca cccatgacgt gggactgtgt gtgcgttggt gtgtatttcc     5100

tttgcattgc tgccataaca aattacccta aa                                   5132


<210>  4
<211>  196
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Amino acid of human IL28B (containing 70K)

<400>  4

Met Thr Gly Asp Cys Met Pro Val Leu Val Leu Met Ala Ala Val Leu 
1               5                   10                  15      


Thr Val Thr Gly Ala Val Pro Val Ala Arg Leu Arg Gly Ala Leu Pro 
            20                  25                  30          


Asp Ala Arg Gly Cys His Ile Ala Gln Phe Lys Ser Leu Ser Pro Gln 
        35                  40                  45              


Glu Leu Gln Ala Phe Lys Arg Ala Lys Asp Ala Leu Glu Glu Ser Leu 
    50                  55                  60                  


Leu Leu Lys Asp Cys Lys Cys Arg Ser Arg Leu Phe Pro Arg Thr Trp 
65                  70                  75                  80  


Asp Leu Arg Gln Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala 
                85                  90                  95      


Glu Leu Ala Leu Thr Leu Lys Val Leu Glu Ala Thr Ala Asp Thr Asp 
            100                 105                 110         


Pro Ala Leu Gly Asp Val Leu Asp Gln Pro Leu His Thr Leu His His 
        115                 120                 125             


Ile Leu Ser Gln Leu Arg Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly 
    130                 135                 140                 


Pro Arg Thr Arg Gly Arg Leu His His Trp Leu His Arg Leu Gln Glu 
145                 150                 155                 160 


Ala Pro Lys Lys Glu Ser Pro Gly Cys Leu Glu Ala Ser Val Thr Phe 
                165                 170                 175     


Asn Leu Phe Arg Leu Leu Thr Arg Asp Leu Asn Cys Val Ala Ser Gly 
            180                 185                 190         


Asp Leu Cys Val 
        195     


<210>  5
<211>  3094
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  DNA of human IL29 (promoter + gene)

<400>  5
acatagtaaa acccagtctc tactaaaaat acaaaaacta gccaggcgtg atggcatgca       60

cctgtaatcc caactactta ggaggctgag gcaggagaat cgcttcaact cgggaggcag      120

aagttgcagt gagccaagat tgcaccattg cactccagcc tgggcaacaa gagcaaaact      180

acgtctcaaa aaataataat aacaataaaa taaaaaacaa gctttttttt ttttgaaaca      240

ggatctcact ccatcaccca ggctggagtg cagtggcacg atcttggctc actgcaacct      300

ccgcctcccg ggttcaagtg attctcatgc ctcggcctcc tgagtagctg agaccacagg      360

cgcatgccac cacacctggc taatttagaa taaaaaagaa gcttcctctc tgccactcag      420

gtagccttat ccctaatctc agcctccgtc agggactccc tgaggccagt tggctgaaag      480

ctgcccaggg agttctaagg atttcagttt ctctttcctt cttgatgcag ctcccagctc      540

acttggccct gcccacacct gttccctcat caggctccca gacgggcccc gcccactcat      600

gcctcttaag tcaaagtgga aattctcatt tccaattacc ttttcacttt acacacatca      660

tcttggattg cccattttgc gtggctaaaa agcagagcca tgccgctggg gaagcagttg      720

cgatttagcc atggctgcag cttggaccgt ggtgctggtg actttggtgc taggcttggc      780

cgtggcaggc cctgtcccca cttccaagcc caccacaact gggaagggct gccacattgg      840

caggttcaaa tctctgtcac cacaggagct agcgagcttc aagaaggcca gggacgcctt      900

ggtgagttcc tgttgctgtg gatgaaccac ttctacgggt gtcccaatta ctgcccttct      960

actgtgggct agcctctagc cttccaacta tggcaaacct ctatcctttc tgcactgggt     1020

taaacccatg ctgtcaggcc aacttcatcc ttgctgctat gagctagctt ccagccatcc     1080

tgctgtgggc taacccctgc ccttgctctc taggaagagt cactcaagct gaaaaactgg     1140

agttgcagct ctcctgtctt ccccgggaat tgggacctga ggcttctcca ggtgagctga     1200

aagtcaggcc cccttcaccc ttcccttgac cctctccccc ctcttcttaa gtggcccctt     1260

agccttcttt gtttcccttg tccttcactc tcttggacct ctcctcacct gtcctgtgcc     1320

cctgccactt caaaactgct ctcttgactc tgtccttccc ctgggtccct tttatcatct     1380

cccatcggcc ccacttccct agctcgctca cctgtccctg tcacttccac tctcactctt     1440

catttctctc ccaaatgtct ccagtctgtc gcccacctgt gcctttcgtc ctgctccact     1500

tctccctgtc tgttcccaac actgaccccc tctccctctc acctgcctct gtcacctgtc     1560

cctcattatc tctcactgac attcatccag ctcatgctcc cccctcatcc acccttctct     1620

tttttttttt tttttttttt tttttgagac agagtcttgc tctatggccc aggctggagt     1680

gcagtggcat gatctcggtt cactgcaacc tctgcctccc gggttcaagc aattatcctg     1740

cctcagcctc ccgagtagct gggattacag gcatgtgcca tgatgcccag ctaatttttg     1800

tatttttagc agagacgggg tttcactatg ttggccaggc ttggtctcga aatcctgacc     1860

tcaggtgatc cacccgcctc ggcctcccaa agtgctggga ttacaggcgt gagccaccac     1920

acccagccct acccttcttc tctgtgcatg caactgtccc tctcttactg tgcccccaac     1980

ctgctttctc ctcacccgtc cccaccccgc cccagagaac ttctgtgacc cccgtaagtc     2040

ccctttcatt tgtctccatt tcacttatcc cctcacctgc ctccttgacc atcctgcctc     2100

acctgtatcc ttcctcatgt cttccccctc ctgtctcctt ctccccagac ccctcacctg     2160

tccccaccac atgcactgtg tcaccgacct tccccaggac tgcctacctg tccccactaa     2220

ctgggtcttc ttgcctgttc tccctcacct gctctttctc acctctcctc aggtgaggga     2280

gcgccctgtg gccttggagg ctgagctggc cctgacgctg aaggtcctgg aggccgctgc     2340

tggcccagcc ctggaggacg tcctagacca gccccttcac accctgcacc acatcctctc     2400

ccagctccag gcctgtgtga gtccttgggg cccgggcacc caggtctgtg ggctctgagc     2460

agcatccttc ccctgtggtg gcccaggctc cgcctcacac accgccctct tctgcccaca     2520

gatccagcct cagcccacag cagggcccag gccccggggc cgcctccacc actggctgca     2580

ccggctccag gaggccccca aaaaggtgag tgacccagga agagaaggac cagggtctgg     2640

ggagccaata ggagcccaga ccctggacag cccctgaccc atcccctcct cccctacagg     2700

agtccgctgg ctgcctggag gcatctgtca ccttcaacct cttccgcctc ctcacgcgag     2760

acctcaaata tgtggccgat gggaacctgt gtctgagaac gtcaacccac cctgagtcca     2820

cctgacaccc cacaccttat ttatgcgctg agccctactc cttccttaat ttatttcctc     2880

tcacccttta tttatgaagc tgcagccctg actgagacat agggctgagt ttattgtttt     2940

acttttatac attatgcaca aataaacaac aaggaattgg aaccttctgt gataggtgaa     3000

tccttgagtg tgtgtgtgat tgtgggtctg tgactgggtg tggatgtctg ggtgatgcag     3060

gcaaaatttg tgactcgttg tgtatatttg tgtg                                 3094


<210>  6
<211>  200
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Amino acid sequence of human IL29 (containing D188N)

<400>  6

Met Ala Ala Ala Trp Thr Val Val Leu Val Thr Leu Val Leu Gly Leu 
1               5                   10                  15      


Ala Val Ala Gly Pro Val Pro Thr Ser Lys Pro Thr Thr Thr Gly Lys 
            20                  25                  30          


Gly Cys His Ile Gly Arg Phe Lys Ser Leu Ser Pro Gln Glu Leu Ala 
        35                  40                  45              


Ser Phe Lys Lys Ala Arg Asp Ala Leu Glu Glu Ser Leu Lys Leu Lys 
    50                  55                  60                  


Asn Trp Ser Cys Ser Ser Pro Val Phe Pro Gly Asn Trp Asp Leu Arg 
65                  70                  75                  80  


Leu Leu Gln Val Arg Glu Arg Pro Val Ala Leu Glu Ala Glu Leu Ala 
                85                  90                  95      


Leu Thr Leu Lys Val Leu Glu Ala Ala Ala Gly Pro Ala Leu Glu Asp 
            100                 105                 110         


Val Leu Asp Gln Pro Leu His Thr Leu His His Ile Leu Ser Gln Leu 
        115                 120                 125             


Gln Ala Cys Ile Gln Pro Gln Pro Thr Ala Gly Pro Arg Pro Arg Gly 
    130                 135                 140                 


Arg Leu His His Trp Leu His Arg Leu Gln Glu Ala Pro Lys Lys Glu 
145                 150                 155                 160 


Ser Ala Gly Cys Leu Glu Ala Ser Val Thr Phe Asn Leu Phe Arg Leu 
                165                 170                 175     


Leu Thr Arg Asp Leu Lys Tyr Val Ala Asp Gly Asn Leu Cys Leu Arg 
            180                 185                 190         


Thr Ser Thr His Pro Glu Ser Thr 
        195                 200 


