                         SEQUENCE LISTING

<110>  Pieris AG
 
<120>  Methods for preventing or treating disorders by increasing 
       bioavailability of iron and related pharmaceutical formulation

<130>  PIE14160PCT

<150>  US 61/569,501
<151>  2011-11-12

<150>  US 61/599,152
<151>  2012-02-15

<160>  7     

<170>  PatentIn version 3.5



<210>  1
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of hNGAL 

<400>  1

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Leu Ala Gly Asn Glu Val Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Met Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Ile Val Met Pro Leu Ala Glu Lys Cys Glu Tyr Leu Phe 
65                  70                  75                  80  
Gln Thr Phe Val Pro Gly Cys Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      
Ile Lys Ser Gly Pro Gly Arg Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Val Val Trp Gln 
        115                 120                 125             
Asn Arg Glu Val Phe Trp Val Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly         



        

<210>  2
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of hNGAL 

<400>  2

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Leu Ala Gly Asn Glu Val Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Met Lys Met Trp Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Ile Val Met Pro Leu Ala Glu Lys Cys Glu Tyr Leu Phe 
65                  70                  75                  80  
Gln Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Gly 
                85                  90                  95      
Ile Lys Ser Gly Pro Gly Arg Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Val Val Trp Gln 
        115                 120                 125             
Asn Arg Glu Val Phe Trp Val Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly         





<210>  3
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  Mutein of hNGAL 


<400>  3

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Leu Ala Gly Asn Glu Val Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Met Lys Met Trp Ala Thr Ile Tyr Glu Leu Glu Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Ile Val Met Phe Leu Ala Lys Lys Cys Glu Tyr Leu Phe 
65                  70                  75                  80  
Gln Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asp 
                85                  90                  95      
Ile Lys Ser Ser Pro Gly Arg Thr Ser Gly Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Thr Val Trp Gln 
        115                 120                 125             
Asn Arg Glu Val Phe Trp Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly         








<210>  4
<211>  178
<212>  PRT
<213>  Artificial

<220>
<223>  wild type hNGAL

<400>  4

Gln Asp Ser Thr Ser Asp Leu Ile Pro Ala Pro Pro Leu Ser Lys Val 
1               5                   10                  15      
Pro Leu Gln Gln Asn Phe Gln Asp Asn Gln Phe His Gly Lys Trp Tyr 
            20                  25                  30          
Val Val Gly Leu Ala Gly Asn Ala Ile Leu Arg Glu Asp Lys Asp Pro 
        35                  40                  45              
Gln Lys Met Tyr Ala Thr Ile Tyr Glu Leu Lys Glu Asp Lys Ser Tyr 
    50                  55                  60                  
Asn Val Thr Ser Val Leu Phe Arg Lys Lys Lys Cys Asp Tyr Trp Ile 
65                  70                  75                  80  
Arg Thr Phe Val Pro Gly Ser Gln Pro Gly Glu Phe Thr Leu Gly Asn 
                85                  90                  95      
Ile Lys Ser Tyr Pro Gly Leu Thr Ser Tyr Leu Val Arg Val Val Ser 
            100                 105                 110         
Thr Asn Tyr Asn Gln His Ala Met Val Phe Phe Lys Lys Val Ser Gln 
        115                 120                 125             
Asn Arg Glu Tyr Phe Lys Ile Thr Leu Tyr Gly Arg Thr Lys Glu Leu 
    130                 135                 140                 
Thr Ser Glu Leu Lys Glu Asn Phe Ile Arg Phe Ser Lys Ser Leu Gly 
145                 150                 155                 160 
Leu Pro Glu Asn His Ile Val Phe Pro Val Pro Ile Asp Gln Cys Ile 
                165                 170                 175     
Asp Gly 





<210>  5
<211>  25
<212>  PRT
<213>  human

<220>
<223>  Hepcidin-25 

<400>  5

Asp Thr His Phe Pro Ile Cys Ile Phe Cys Cys Gly Cys Cys His Arg 
1               5                   10                  15      
Ser Lys Cys Gly Met Cys Cys Lys Thr
            20                  25 


<210>  6
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  variable light chain region of 12B9 antibody from WO 2008/097481
<400>  6

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln
1               5                   10                  15     
Thr Ala Thr Ile Thr Cys Ser Gly Asp Lys Leu Gly Glu Arg Tyr Ala
            20                  25                  30         
Cys Trp Tyr Gln Gln Arg Pro Gly Gln Ser Pro Val Leu Val Ile Tyr
        35                  40                  45             
Gln Asp Ile Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser
    50                  55                  60                 
Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met
65                  70                  75                  80 
Asp Glu Ala Asp Tyr Phe Cys Gln Ala Trp Tyr Ser Ser Thr Asn Val
                85                  90                  95     
Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105


<210>  7
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  variable heavy chain region of 12B9 antibody from WO 2008/097481
<400>  7
     
Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg
1               5                   10                  15     
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30         
Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45             
Ala Val Ile Trp Tyr Ala Glu Ser Asn Lys Tyr Tyr Ala Asp Ser Val
    50                  55                  60                 
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80 
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95     
Ala Arg Ala Gln Glu Gly Ile Ala Pro Asp Ala Phe Asp Ile Trp Gly
            100                 105                 110        
Gln Gly Thr Met Val Thr Val Ser Ser
        115                 120

              

     



