                         SEQUENCE LISTING

<110>  BRITISH COLUMBIA CANCER AGENCY BRANCH
       THE UNIVERSITY OF BRITISH COLUMBIA
 
<120>  MUTATIONS INDICATIVE OF WEAVER SYNDROME

<130>  PAT 101721W-90

<140>  PCT/CA2012/050902
<141>  2012-12-14

<150>  US 61/570,780
<151>  2011-12-14

<160>  151   

<170>  PatentIn version 3.5

<210>  1
<211>  2723
<212>  DNA
<213>  Homo sapiens


<220>
<223>  enhancer of zeste homolog 2 (Drosophila) (EZH2)

<400>  1
ggcggcgctt gattgggctg ggggggccaa ataaaagcga tggcgattgg gctgccgcgt       60

ttggcgctcg gtccggtcgc gtccgacacc cggtgggact cagaaggcag tggagccccg      120

gcggcggcgg cggcggcgcg cgggggcgac gcgcgggaac aacgcgagtc ggcgcgcggg      180

acgaagaata atcatgggcc agactgggaa gaaatctgag aagggaccag tttgttggcg      240

gaagcgtgta aaatcagagt acatgcgact gagacagctc aagaggttca gacgagctga      300

tgaagtaaag agtatgttta gttccaatcg tcagaaaatt ttggaaagaa cggaaatctt      360

aaaccaagaa tggaaacagc gaaggataca gcctgtgcac atcctgactt ctgtgagctc      420

attgcgcggg actagggagt gttcggtgac cagtgacttg gattttccaa cacaagtcat      480

cccattaaag actctgaatg cagttgcttc agtacccata atgtattctt ggtctcccct      540

acagcagaat tttatggtgg aagatgaaac tgttttacat aacattcctt atatgggaga      600

tgaagtttta gatcaggatg gtactttcat tgaagaacta ataaaaaatt atgatgggaa      660

agtacacggg gatagagaat gtgggtttat aaatgatgaa atttttgtgg agttggtgaa      720

tgcccttggt caatataatg atgatgacga tgatgatgat ggagacgatc ctgaagaaag      780

agaagaaaag cagaaagatc tggaggatca ccgagatgat aaagaaagcc gcccacctcg      840

gaaatttcct tctgataaaa tttttgaagc catttcctca atgtttccag ataagggcac      900

agcagaagaa ctaaaggaaa aatataaaga actcaccgaa cagcagctcc caggcgcact      960

tcctcctgaa tgtaccccca acatagatgg accaaatgct aaatctgttc agagagagca     1020

aagcttacac tcctttcata cgcttttctg taggcgatgt tttaaatatg actgcttcct     1080

acatcgtaag tgcaattatt cttttcatgc aacacccaac acttataagc ggaagaacac     1140

agaaacagct ctagacaaca aaccttgtgg accacagtgt taccagcatt tggagggagc     1200

aaaggagttt gctgctgctc tcaccgctga gcggataaag accccaccaa aacgtccagg     1260

aggccgcaga agaggacggc ttcccaataa cagtagcagg cccagcaccc ccaccattaa     1320

tgtgctggaa tcaaaggata cagacagtga tagggaagca gggactgaaa cggggggaga     1380

gaacaatgat aaagaagaag aagagaagaa agatgaaact tcgagctcct ctgaagcaaa     1440

ttctcggtgt caaacaccaa taaagatgaa gccaaatatt gaacctcctg agaatgtgga     1500

gtggagtggt gctgaagcct caatgtttag agtcctcatt ggcacttact atgacaattt     1560

ctgtgccatt gctaggttaa ttgggaccaa aacatgtaga caggtgtatg agtttagagt     1620

caaagaatct agcatcatag ctccagctcc cgctgaggat gtggatactc ctccaaggaa     1680

aaagaagagg aaacaccggt tgtgggctgc acactgcaga aagatacagc tgaaaaagga     1740

cggctcctct aaccatgttt acaactatca accctgtgat catccacggc agccttgtga     1800

cagttcgtgc ccttgtgtga tagcacaaaa tttttgtgaa aagttttgtc aatgtagttc     1860

agagtgtcaa aaccgctttc cgggatgccg ctgcaaagca cagtgcaaca ccaagcagtg     1920

cccgtgctac ctggctgtcc gagagtgtga ccctgacctc tgtcttactt gtggagccgc     1980

tgaccattgg gacagtaaaa atgtgtcctg caagaactgc agtattcagc ggggctccaa     2040

aaagcatcta ttgctggcac catctgacgt ggcaggctgg gggattttta tcaaagatcc     2100

tgtgcagaaa aatgaattca tctcagaata ctgtggagag attatttctc aagatgaagc     2160

tgacagaaga gggaaagtgt atgataaata catgtgcagc tttctgttca acttgaacaa     2220

tgattttgtg gtggatgcaa cccgcaaggg taacaaaatt cgttttgcaa atcattcggt     2280

aaatccaaac tgctatgcaa aagttatgat ggttaacggt gatcacagga taggtatttt     2340

tgccaagaga gccatccaga ctggcgaaga gctgtttttt gattacagat acagccaggc     2400

tgatgccctg aagtatgtcg gcatcgaaag agaaatggaa atcccttgac atctgctacc     2460

tcctcccccc tcctctgaaa cagctgcctt agcttcagga acctcgagta ctgtgggcaa     2520

tttagaaaaa gaacatgcag tttgaaattc tgaatttgca aagtactgta agaataattt     2580

atagtaatga gtttaaaaat caacttttta ttgccttctc accagctgca aagtgttttg     2640

taccagtgaa tttttgcaat aatgcagtat ggtacatttt tcaactttga ataaagaata     2700

cttgaacttg tccttgttga atc                                             2723


<210>  2
<211>  2256
<212>  DNA
<213>  Homo sapiens


<220>
<223>  enhancer of zeste homolog 2 (Drosophila) (EZH2)

<400>  2
atgggccaga ctgggaagaa atctgagaag ggaccagttt gttggcggaa gcgtgtaaaa       60

tcagagtaca tgcgactgag acagctcaag aggttcagac gagctgatga agtaaagagt      120

atgtttagtt ccaatcgtca gaaaattttg gaaagaacgg aaatcttaaa ccaagaatgg      180

aaacagcgaa ggatacagcc tgtgcacatc ctgacttctg tgagctcatt gcgcgggact      240

agggagtgtt cggtgaccag tgacttggat tttccaacac aagtcatccc attaaagact      300

ctgaatgcag ttgcttcagt acccataatg tattcttggt ctcccctaca gcagaatttt      360

atggtggaag atgaaactgt tttacataac attccttata tgggagatga agttttagat      420

caggatggta ctttcattga agaactaata aaaaattatg atgggaaagt acacggggat      480

agagaatgtg ggtttataaa tgatgaaatt tttgtggagt tggtgaatgc ccttggtcaa      540

tataatgatg atgacgatga tgatgatgga gacgatcctg aagaaagaga agaaaagcag      600

aaagatctgg aggatcaccg agatgataaa gaaagccgcc cacctcggaa atttccttct      660

gataaaattt ttgaagccat ttcctcaatg tttccagata agggcacagc agaagaacta      720

aaggaaaaat ataaagaact caccgaacag cagctcccag gcgcacttcc tcctgaatgt      780

acccccaaca tagatggacc aaatgctaaa tctgttcaga gagagcaaag cttacactcc      840

tttcatacgc ttttctgtag gcgatgtttt aaatatgact gcttcctaca tcgtaagtgc      900

aattattctt ttcatgcaac acccaacact tataagcgga agaacacaga aacagctcta      960

gacaacaaac cttgtggacc acagtgttac cagcatttgg agggagcaaa ggagtttgct     1020

gctgctctca ccgctgagcg gataaagacc ccaccaaaac gtccaggagg ccgcagaaga     1080

ggacggcttc ccaataacag tagcaggccc agcaccccca ccattaatgt gctggaatca     1140

aaggatacag acagtgatag ggaagcaggg actgaaacgg ggggagagaa caatgataaa     1200

gaagaagaag agaagaaaga tgaaacttcg agctcctctg aagcaaattc tcggtgtcaa     1260

acaccaataa agatgaagcc aaatattgaa cctcctgaga atgtggagtg gagtggtgct     1320

gaagcctcaa tgtttagagt cctcattggc acttactatg acaatttctg tgccattgct     1380

aggttaattg ggaccaaaac atgtagacag gtgtatgagt ttagagtcaa agaatctagc     1440

atcatagctc cagctcccgc tgaggatgtg gatactcctc caaggaaaaa gaagaggaaa     1500

caccggttgt gggctgcaca ctgcagaaag atacagctga aaaaggacgg ctcctctaac     1560

catgtttaca actatcaacc ctgtgatcat ccacggcagc cttgtgacag ttcgtgccct     1620

tgtgtgatag cacaaaattt ttgtgaaaag ttttgtcaat gtagttcaga gtgtcaaaac     1680

cgctttccgg gatgccgctg caaagcacag tgcaacacca agcagtgccc gtgctacctg     1740

gctgtccgag agtgtgaccc tgacctctgt cttacttgtg gagccgctga ccattgggac     1800

agtaaaaatg tgtcctgcaa gaactgcagt attcagcggg gctccaaaaa gcatctattg     1860

ctggcaccat ctgacgtggc aggctggggg atttttatca aagatcctgt gcagaaaaat     1920

gaattcatct cagaatactg tggagagatt atttctcaag atgaagctga cagaagaggg     1980

aaagtgtatg ataaatacat gtgcagcttt ctgttcaact tgaacaatga ttttgtggtg     2040

gatgcaaccc gcaagggtaa caaaattcgt tttgcaaatc attcggtaaa tccaaactgc     2100

tatgcaaaag ttatgatggt taacggtgat cacaggatag gtatttttgc caagagagcc     2160

atccagactg gcgaagagct gttttttgat tacagataca gccaggctga tgccctgaag     2220

tatgtcggca tcgaaagaga aatggaaatc ccttga                               2256


<210>  3
<211>  751
<212>  PRT
<213>  Homo sapiens


<220>
<223>  enhancer of zeste homolog 2 (Drosophila) (EZH2)

<400>  3

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Arg Lys Cys Asn Tyr Ser Phe 
    290                 295                 300                 


His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu 
305                 310                 315                 320 


Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala 
                325                 330                 335     


Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro 
            340                 345                 350         


Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser 
        355                 360                 365             


Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp 
    370                 375                 380                 


Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys 
385                 390                 395                 400 


Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn 
                405                 410                 415     


Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro 
            420                 425                 430         


Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu 
        435                 440                 445             


Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly 
    450                 455                 460                 


Thr Lys Thr Cys Arg Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser 
465                 470                 475                 480 


Ile Ile Ala Pro Ala Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys 
                485                 490                 495     


Lys Lys Arg Lys His Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln 
            500                 505                 510         


Leu Lys Lys Asp Gly Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys 
        515                 520                 525             


Asp His Pro Arg Gln Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala 
    530                 535                 540                 


Gln Asn Phe Cys Glu Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn 
545                 550                 555                 560 


Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys 
                565                 570                 575     


Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr 
            580                 585                 590         


Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn 
        595                 600                 605             


Cys Ser Ile Gln Arg Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser 
    610                 615                 620                 


Asp Val Ala Gly Trp Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn 
625                 630                 635                 640 


Glu Phe Ile Ser Glu Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala 
                645                 650                 655     


Asp Arg Arg Gly Lys Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe 
            660                 665                 670         


Asn Leu Asn Asn Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys 
        675                 680                 685             


Ile Arg Phe Ala Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val 
    690                 695                 700                 


Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala 
705                 710                 715                 720 


Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala 
                725                 730                 735     


Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745                 750     


<210>  4
<211>  400
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 2 with partial flanking regions

<400>  4
catttcttca ctgattgtta gtttgctgcg gattaaaaca caggtgatca tattcaggct       60

ggttagatta gtgattttaa tatgaaacca ttgcttttag aataatcatg ggccagactg      120

ggaagaaatc tgagaaggga ccagtttgtt ggcggaagcg tgtaaaatca gagtacatgc      180

gactgagaca gctcaagagg ttcagacgag ctgatgaagt aaaggtataa ttttatcttt      240

tgtgaaaatg aatatacaat taaggatagg ttttttcccc tcctaagttc aataagtttt      300

tatttaaaat aattctagcc aagtttgtat ttacaataag atgagtgaat acttggaagc      360

ttaggttctt gatctgtctt aacattatac catgcacatt                            400


<210>  5
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 3 with partial flanking regions

<400>  5
ttttgaggat acactagatt tttaacctgc tttacaggtg ttatacattt tctaacaatg       60

aacaatttct cctttcctct ccttcatttt tttttttaag agtatgttta gttccaatcg      120

tcagaaaatt ttggaaagaa cggaaatctt aaaccaagaa tggaaacagc gaaggataca      180

gcctgtgcac atcctgactt ctgtgagctc attgcgcggg actagggagg ttggttaaca      240

taacatgttg tagtaattat catcatcttt tggtttatgc tattggaaca tttgtttggt      300

tattgggagg aaatcattga cctcagggtg tccatctttt tattgctatt                 350


<210>  6
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 4 with partial flanking regions

<400>  6
attaaatatt tgggtaggca gcatctcttt acaatatgat ggctacagct taaggttgtc       60

cttttattct taagagtcaa ttttattttt tctgttttag tgttcggtga ccagtgactt      120

ggattttcca acacaagtca tcccattaaa gactctgaat gcagttgctt cagtacccat      180

aatgtattct tggtctcccc tacagcagaa ttttatggta tgtaaataag atatcttctg      240

cttatttgat aataacttat ttgaagtaaa aaagcataga taattttatt gtcaaggtga      300

atcaagacag tataaattct aaaaagctat caaaataaca cttgaagtaa                 350


<210>  7
<211>  400
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 5 with partial flanking regions

<400>  7
gataaatttt agagtttgct ctctgactag tattttaaat ctggagaact gggtaaagac       60

atgtacacat gaaaaaaagg ttgtatttta gttatttcac atttgatact tagagtaaac      120

ctgcttttta aatatatttt tttcttttag gtggaagatg aaactgtttt acataacatt      180

ccttatatgg gagatgaagt tttagatcag gatggtactt tcattgaaga actaataaaa      240

aattatgatg ggaaagtaca cggggataga ggtgagccat atgcttcttc tcttggaaaa      300

aggggctaaa gaattgagag acacttttgt ttatgaagca tatagggcat gagaaaaatt      360

ttaatattaa aattaagttt tgcactgaac tataagggac                            400


<210>  8
<211>  450
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 6 with partial flanking regions

<400>  8
agttactagg ctatgcctgt tttgtccaag tagaaaaagg atacataaac ttttgacatt       60

attgcttctc ctgtgtgttt ctgacatttg atgcgtttca gaatgtgggt ttataaatga      120

tgaaattttt gtggagttgg tgaatgccct tggtcaatat aatgatgatg acgatgatga      180

tgatggagac gatcctgaag aaagagaaga aaagcagaaa gatctggagg atcaccgaga      240

tggtatgcct gattattagg attctgtgta gccattacag ctttctttca aaaacagtag      300

aaagagtaga aatagggctt agtttcttct ttctcttttt ctttctttgt taaatatcac      360

attgatagca gtataatcaa aattaacata ttatggccag gtagggtggc taactctgta      420

atcctagcac ttgggaggct aaggtgggca                                       450


<210>  9
<211>  400
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 7 with partial flanking regions

<400>  9
taaagtatgt gagaagtaag taaaacacaa aatagagatg atttcttaga aaatcagctt       60

tgttatagag acataattgg gtagagaaaa tgaaagatca aaaacttgtt tacttccatt      120

ctttttttcc tttcatattc tcctgtttag ataaagaaag ccgcccacct cggaaatttc      180

cttctgataa aatttttgaa gccatttcct caatgtttcc agataagggc acagcagaag      240

aactaaagga aaagtaagaa tttgttcctt tgaggcaatc ttgccctgta tggtatgtaa      300

ctcaccattt tggtttatta caaatggaat caatgtagcg gatgagccac tacactttgt      360

ttacagtgtt tgcaagatac ttgaagcaac atgtgtactt                            400


<210>  10
<211>  450
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 8 with partial flanking regions

<400>  10
tttagttggc tctttatcta aatagagcca ttcctttatg ttttaggcaa gataaacatc       60

aaaagtaaca catggaaacc ttttagaaac tgttttcaaa aaagtgattt ttgtttcatg      120

tttacttaaa tttttcttgg ttaatgtcag atataaagaa ctcaccgaac agcagctccc      180

aggcgcactt cctcctgaat gtacccccaa catagatgga ccaaatgcta aatctgttca      240

gagagagcaa agcttacact cctttcatac gcttttctgt aggcgatgtt ttaaatatga      300

ctgcttccta catcgtaagt gcaattattg tacgttttca ttttctatct ttgttgtgga      360

attatgtttt aaagcagctt ggagagtgct atcatttatt acaactagaa tttatcattt      420

aatcttgtag ttactttgac aaatatcttt                                       450


<210>  11
<211>  300
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 9 with partial flanking regions

<400>  11
agattataat ccattaattg acttttccag tggaactgga agagtgaaaa agtaagtatt       60

ttatagttat attagattct ttgtttcatt tattttgcag cttttcatgc aacacccaac      120

acttataagc ggaagaacac agaaacagct ctagacaaca aaccttgtgg accacagtgt      180

taccagcatt tggtaagact tagtgcctaa ttattgcaga gggtacttga gaggactttg      240

cactttggtg gaggtgatca agtcagcgtt aatgttgtct gcacccatgc tgttatgggc      300


<210>  12
<211>  600
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 10 with partial flanking regions

<400>  12
aagtatatta gacatgcaaa tgattatttg tgataaatgg ataatgtgat acattttttg       60

actaacctgg cttatatagt attttttttt ctcttccatc aaaatgagtt ttagaacttt      120

gccctgatgt tgacattttt catttcgtag gagggagcaa aggagtttgc tgctgctctc      180

accgctgagc ggataaagac cccaccaaaa cgtccaggag gccgcagaag aggacggctt      240

cccaataaca gtagcaggcc cagcaccccc accattaatg tgctggaatc aaaggataca      300

gacagtgata gggaagcagg gactgaaacg gggggagaga acaatgataa agaagaagaa      360

gagaagaaag atgaaacttc gagctcctct ggtaagacac gtctaataac tgggttttac      420

tgttctgtga aagttcgtgt tgtgaggatt aaggatgtat aatgcattga ataattttct      480

tagttggtta gtttcagtat aaagaccaga gttatctcaa gaatgtgtag ctgtgttgtt      540

tctgtttcct gcctgcaccc gtaccctagc ttgtggtgtt tgccctgctt ggttgtttga      600


<210>  13
<211>  450
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 11 with partial flanking regions

<400>  13
ggaaaatgtg aactacgatg ggttagtgtt ttgccgattg gatttgagtt gtcctcatct       60

tttcgctttt ttcttaagca caccctgaat tgtacttctt aatattattt ccaatcattt      120

cttgaccagt gcttacattt ggttttgtag aagcaaattc tcggtgtcaa acaccaataa      180

agatgaagcc aaatattgaa cctcctgaga atgtggagtg gagtggtgct gaagcctcaa      240

tgtttagagt cctcattggc acttactatg acaatttctg tgccattgct aggttaattg      300

ggaccaaaac atgtagacag gtaagatatc cgataaaaat gttgttaaaa gagcttcaaa      360

catagagata aaactgtact cgttgtccaa acaaagaaaa ttcttggtta ttactaagct      420

cctattcatc tcctaaaaat aatttttttt                                       450


<210>  14
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 12 with partial flanking regions

<400>  14
gtgagggtag ggacagcgat gtgtgttata tccccagcat ctagcagtgt cacagaagag       60

acaaagacat ttttctggta tgcatgagta taagaatggt ttgcctaaat aagactgtcc      120

tcatggctct gtgactgtgc ctcttgtcag gtgtatgagt ttagagtcaa agaatctagc      180

atcatagctc cagctcccgc tgaggatgtg gatactcctc caaggaaaaa gaagaggaaa      240

caccggtgag tctgtcatga agctccttag agaagtcaac atagatagac actgcaggca      300

aggcccttcc taagggctgt tgttggtttc tacttagtct atttttaaaa                 350


<210>  15
<211>  300
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 13 with partial flanking regions

<400>  15
actgatggca aatataaact gggcagggca tgactcttgg ctttaacgca ttcctgtatt       60

catggcacag atagatccag ttaagcagct ctctgttgga tttgtagctt cccgcagaaa      120

tttggtttaa ttttctttgt gtttttgcag gttgtgggct gcacactgca gaaagataca      180

gctgaaaaag ggttagcatc tttccattcc tctcattatt agcttaacaa tatctgcttt      240

gttttcattt gttttagaat agtaactgga ttagagcttg ggttattcta atataattgc      300


<210>  16
<211>  400
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 14 with partial flanking regions

<400>  16
gaaaccggaa tatgtgtaat gttatgcatt cagtaaaggc aggccagcta cactccacag       60

gtagtaggga agaatgtact cgtgttaatt gtgtatgatc gtttccatct ccctggattc      120

attggcctgc atgatgttat ctttactcag acggctcctc taaccatgtt tacaactatc      180

aaccctgtga tcatccacgg cagccttgtg acagttcgtg cccttgtgtg atagcacaaa      240

atttttgtga aaagttttgt caatgtagtt cagagtgtaa gtatttgttg ctttgatgca      300

attgcatgag aactaaatag gtctttggtt agcaatttaa aaaatcaaaa ataagaacat      360

gggagcactc ccttgtttac ttgacgaaac tcatcaattt                            400


<210>  17
<211>  400
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 15 with partial flanking regions

<400>  17
tgagagtcag tgagatgccc agtacagccc ttgccacgta tctttctgca agtttttgca       60

tacggtgatg agtgaagaac ctccaaacct ctctctgaag gtcaaaaccg ctttccggga      120

tgccgctgca aagcacagtg caacaccaag cagtgcccgt gctacctggc tgtccgagag      180

tgtgaccctg acctctgtct tacttgtgga gccgctgacc attgggacag taaaaatgtg      240

tcctgcaaga actgcagtat tcagcggggc tccaaaaagg tgagcaacaa gtcacttctg      300

gaagattgtt tgtagttagc tatttagtga tgcaaatgtc aggattgcct tagatgattt      360

agctggggca aaaagtaaaa gtgatccttg aaaggtgcaa                            400


<210>  18
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 16 with partial flanking regions

<400>  18
tgactgaagc tgtgtgccca attactgcct tagaacaaac aggtctgagg atttacagtg       60

atagcttttg ttttcattct gtagtctact ttgtccccag tccattttca ccctcctttt      120

ttgatgatgt gattgtgttt tattctctag catctattgc tggcaccatc tgacgtggca      180

ggctggggga tttttatcaa agatcctgtg cagaaaaatg aattcatctc agaatactgt      240

ggagaggtaa ggcactgata acctgtattc aggtggcatt gtatatacta actttacttt      300

attttagatt gattttatta ggtaagtctg tgggtttgat tggaaatgaa                 350


<210>  19
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 17 with partial flanking regions

<400>  19
gaccgaatgg gaaagagaac ttggctgtag tgaccctttt tgttgcgttt tctccagaag       60

gtccagtatt cactctgtgc gcttttgtgt gttctgtcag gcttgatcac ctttatccaa      120

aagaattttc tcctgtgtct ttctttttag attatttctc aagatgaagc tgacagaaga      180

gggaaagtgt atgataaata catgtgcagc tttctgttca acttgaacaa tggtatgttt      240

cagagctggg aggcagtgag ttcctgagtt gcatgtggca gccttctgcc ggccgagtgt      300

tcagaaacga gggtagaggt cagtgaggtg accagaagga ggatctcctt                 350


<210>  20
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 18 with partial flanking regions

<400>  20
tcatttctta ctgaatgaag ctgcttgatt tatttgcttt tgcaggcaaa ccctgaagaa       60

ctgtaaccag ttgcatttac aaaatcataa taacttggtt tacttataac tgaaattatt      120

cactgggctg tgcttacttt tttcttttta gattttgtgg tggatgcaac ccgcaagggt      180

aacaaaattc gttttgcaaa tcattcggta aatccaaact gctatgcaaa aggtaggtac      240

ctttgacgtg agaattggaa ctcccttttc agtcctgtga tgatggactt gaatacttct      300

gggatagttg tttgttatgt gaacaagtca gttaaccccc cgtggcccgt                 350


<210>  21
<211>  350
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 19 with partial flanking regions

<400>  21
ggtacctttg acgtgagaat tggaactccc ttttcagtcc tgtgatgatg gacttgaata       60

cttctgggat agttgtttgt tatgtgaaca agtcagttaa ccccccgtgg cccgtcttca      120

tgctcactga caccagtgtg tctctttgca gttatgatgg ttaacggtga tcacaggata      180

ggtatttttg ccaagagagc catccagact ggcgaagagc tgttttttga ttacaggttg      240

gtaaagtaca tttctagcat gatctctaag ggctttttct actggattgt gaactctgga      300

caaaggaggg tttttagttc tttgcttctt ttgatgggtc actttgccat                 350


<210>  22
<211>  550
<212>  DNA
<213>  Homo sapiens

<220>
<223>  exon 20 with partial flanking regions

<400>  22
tttaatgcac ccactatctt cagcaggctt tgttgtgtta agtctcagca catgttggat       60

gggtggccat ccagcggaca tctccttcct gttgtttcag atacagccag gctgatgccc      120

tgaagtatgt cggcatcgaa agagaaatgg aaatcccttg acatctgcta cctcctcccc      180

cctcctctga aacagctgcc ttagcttcag gaacctcgag tactgtgggc aatttagaaa      240

aagaacatgc agtttgaaat tctgaatttg caaagtactg taagaataat ttatagtaat      300

gagtttaaaa atcaactttt tattgccttc tcaccagctg caaagtgttt tgtaccagtg      360

aatttttgca ataatgcagt atggtacatt tttcaacttt gaataaagaa tacttgaact      420

tgtccttgtt gaatcatctc tcataacgtg tcaataactg ctttcaggac tgctcaacaa      480

aaaactttta aatttaactc cttgggtttt ttagttgtct ttgtatgaat cttgatttaa      540

ctaatactgc                                                             550


<210>  23
<211>  50
<212>  DNA
<213>  Homo sapiens

<220>
<223>  reference DNA sequence

<400>  23
tttagatcag gatggtactt tcattgaaga actaataaaa aattatgatg                  50


<210>  24
<211>  47
<212>  DNA
<213>  Homo sapiens

<220>
<223>  Patient DNA sequence

<400>  24
tttagatcag gatggtactt tcattgaaga actaataaaa aatgatg                     47


<210>  25
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  reference amino acid sequence

<400>  25

Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp 
1               5                   10                  15      


Gly 
    


<210>  26
<211>  16
<212>  PRT
<213>  Homo sapiens

<220>
<223>  patient amino acid sequence

<400>  26

Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys Asn Asp Gly 
1               5                   10                  15      


<210>  27
<211>  50
<212>  DNA
<213>  Homo sapiens

<220>
<223>  reference DNA sequence

<400>  27
tcattcggta aatccaaact gctatgcaaa aggtaggtac ctttgacgtg                  50


<210>  28
<211>  50
<212>  DNA
<213>  Homo sapiens

<220>
<223>  patient DNA sequence

<400>  28
ttattcggta aatccaaact gctatgcaaa aggtaggtac ctttgacgtg                  50


<210>  29
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  reference amino acid sequence

<400>  29

His Ser Val Asn Pro Asn Cys Tyr Ala Lys 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Homo sapiens

<220>
<223>  patient amino acid sequence

<400>  30

Tyr Ser Val Asn Pro Asn Cys Tyr Ala Lys 
1               5                   10  


<210>  31
<211>  50
<212>  DNA
<213>  Homo sapiens

<220>
<223>  reference DNA sequence

<400>  31
gtggaagatg aaactgtttt acataacatt ccttatatgg gagatgaagt                  50


<210>  32
<211>  50
<212>  DNA
<213>  Homo sapiens

<220>
<223>  patient DNA sequence

<400>  32
gtggaagatg aaactgtttt acataacatt tcttgtatgg gagatgaagt                  50


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  reference amino acid sequence

<400>  33

Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly Asp Glu 
1               5                   10                  15      


Val 
    


<210>  34
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  patient amino acid sequence

<400>  34

Val Glu Asp Glu Thr Val Leu His Asn Ile Ser Cys Met Gly Asp Glu 
1               5                   10                  15      


Val 
    


<210>  35
<211>  50
<212>  DNA
<213>  Homo sapiens

<220>
<223>  patient DNA sequence

<400>  35
gtggaagatg aaactgtttt acataacatt ccttgtatgg gagatgaagt                  50


<210>  36
<211>  17
<212>  PRT
<213>  Homo sapiens

<220>
<223>  patient amino acid sequence

<400>  36

Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Cys Met Gly Asp Glu 
1               5                   10                  15      


Val 
    


<210>  37
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex2.F

<400>  37
cagatcaaga acctaagctt cca                                               23


<210>  38
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex2.R

<400>  38
tagtttgctg cggattaaaa ca                                                22


<210>  39
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex3.F

<400>  39
gacaccctga ggtcaatgat tt                                                22


<210>  40
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex3.R

<400>  40
tttttaacct gctttacagg tgtt                                              24


<210>  41
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex4.F

<400>  41
tcttgattca ccttgacaat aaaa                                              24


<210>  42
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex4.R

<400>  42
atttgggtag gcagcatctc t                                                 21


<210>  43
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex5.F

<400>  43
tgccctatat gcttcataaa caa                                               23


<210>  44
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex5.R

<400>  44
tgggtaaaga catgtacaca tgaaa                                             25


<210>  45
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex6.F

<400>  45
cctggccata atatgttaat tttg                                              24


<210>  46
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex6.R

<400>  46
actaggctat gcctgttttg tcc                                               23


<210>  47
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex7.F

<400>  47
gctcatccgc tacattgatt                                                   20


<210>  48
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex7.R

<400>  48
agaaaatcag ctttgttata gagacat                                           27


<210>  49
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex8.F

<400>  49
aaatgatagc actctccaag ctg                                               23


<210>  50
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex8.R

<400>  50
gccattcctt tatgttttag gc                                                22


<210>  51
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex9.F

<400>  51
agcatgggtg cagacaacat                                                   20


<210>  52
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex9.R

<400>  52
tccattaatt gacttttcca gtg                                               23


<210>  53
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex10.F

<400>  53
tctggtcttt atactgaaac taaccaa                                           27


<210>  54
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex10.R

<400>  54
gattatttgt gataaatgga taatgtg                                           27


<210>  55
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex11.F

<400>  55
tttttaggag atgaatagga gctt                                              24


<210>  56
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex11.R

<400>  56
tgtcctcatc ttttcgcttt t                                                 21


<210>  57
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex12.F

<400>  57
ccaacaacag cccttaggaa                                                   20


<210>  58
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex12.R

<400>  58
cccagcatct agcagtgtca                                                   20


<210>  59
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex13.F

<400>  59
aacccaagct ctaatccagt ta                                                22


<210>  60
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex13.R

<400>  60
tcttggcttt aacgcattcc                                                   20


<210>  61
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex14.F

<400>  61
agggagtgct cccatgttct                                                   20


<210>  62
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex14.R

<400>  62
gccagctaca ctccacaggt                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex15.F

<400>  63
tttgccccag ctaaatcatc                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex15.R

<400>  64
gtacagccct tgccacgtat                                                   20


<210>  65
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex16.F

<400>  65
tccaatcaaa cccacagact t                                                 21


<210>  66
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex16.R

<400>  66
tgaggattta cagtgatagc ttttg                                             25


<210>  67
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex17.F

<400>  67
cctctaccct cgtttctgaa ca                                                22


<210>  68
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex17.R

<400>  68
cttggctgta gtgacccttt tt                                                22


<210>  69
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex18.F

<400>  69
gggggttaac tgacttgttc ac                                                22


<210>  70
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex18.R

<400>  70
aggcaaaccc tgaagaactg ta                                                22


<210>  71
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex19.F

<400>  71
ggcaaagtga cccatcaaaa                                                   20


<210>  72
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex19.R

<400>  72
tggacttgaa tacttctggg ata                                               23


<210>  73
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex20.F

<400>  73
cactttgcag ctggtgagaa                                                   20


<210>  74
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer EZH2_ex20.R

<400>  74
tgcacccact atcttcagca                                                   20


<210>  75
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex1A.F

<400>  75
gcagcagaaa ggcatagagg                                                   20


<210>  76
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex1A.R

<400>  76
tggcattggt ctgagtttcc                                                   20


<210>  77
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex1B.F

<400>  77
ttccttgagt cctggtggtc                                                   20


<210>  78
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex1B.R

<400>  78
tcagctgtga actgataagc aac                                               23


<210>  79
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex2.F

<400>  79
ttcatacatt gctttttcag aagg                                              24


<210>  80
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex2.R

<400>  80
tcattcacaa aatgttccaa gg                                                22


<210>  81
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex3.F

<400>  81
tgtttccaga cagtcttctt tgg                                               23


<210>  82
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex3.R

<400>  82
tccaatctgg gaaacagagc                                                   20


<210>  83
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4A.F

<400>  83
tctgatttca tctccctttt cc                                                22


<210>  84
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4A.R

<400>  84
ggcttcgttg gggtttattc                                                   20


<210>  85
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4B.F

<400>  85
atagcctcac agggtccaac                                                   20


<210>  86
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4B.R

<400>  86
acttgggctg tttgcttttc                                                   20


<210>  87
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4C.F

<400>  87
tctctctgat ctgaaggcat c                                                 21


<210>  88
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4C.R

<400>  88
agcctcctga aaccaaaacc                                                   20


<210>  89
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4D.F

<400>  89
ccagactaca aattcagtac attgc                                             25


<210>  90
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4D.R

<400>  90
ttccgttttc aaaagagagt cc                                                22


<210>  91
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4E.F

<400>  91
cgtggaggtt cattgagagg                                                   20


<210>  92
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex4E.R

<400>  92
caacagacca atttcagaag gac                                               23


<210>  93
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex5.F

<400>  93
atgtggtttc ccatctggtt                                                   20


<210>  94
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex5.R

<400>  94
tgtgctagaa gctgagaata aaaa                                              24


<210>  95
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex6.F

<400>  95
gcctttgtca gaatttcatt cc                                                22


<210>  96
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex6.R

<400>  96
ccaggacaaa agggggtagt                                                   20


<210>  97
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex7.F

<400>  97
catcctgcct cttcccataa                                                   20


<210>  98
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex7.R

<400>  98
tgtatgactg ctgacacaca cac                                               23


<210>  99
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex8.F

<400>  99
tggcagctga caattcagac                                                   20


<210>  100
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex8.R

<400>  100
ctcactggtc gggcttacac                                                   20


<210>  101
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex9.F

<400>  101
tcctaatcca caaagctgga g                                                 21


<210>  102
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex9.R

<400>  102
ttatggccat cagccatttc                                                   20


<210>  103
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex10.F

<400>  103
cgagtgattg gctgaacatc                                                   20


<210>  104
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex10.R

<400>  104
tccactggaa tcatccaaaa g                                                 21


<210>  105
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex11.F

<400>  105
tccttttctg ccacttttaa cc                                                22


<210>  106
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex11.R

<400>  106
cccagtgttg ccacaaaata g                                                 21


<210>  107
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex12.F

<400>  107
ctttctgttg tatcacgtca gg                                                22


<210>  108
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex12.R

<400>  108
aggctgaagc aggagaatgg                                                   20


<210>  109
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex13.F

<400>  109
tttttcagtg ctaacaaata gacttga                                           27


<210>  110
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex13.R

<400>  110
ttccagtggc aatatgatga a                                                 21


<210>  111
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex14.F

<400>  111
atactctggt cattatgtgt cactg                                             25


<210>  112
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex14.R

<400>  112
aagaggggag gagtaccatg a                                                 21


<210>  113
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex15.F

<400>  113
tgtggacaga cagacattgc                                                   20


<210>  114
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex15.R

<400>  114
gccagataat gccctgagag                                                   20


<210>  115
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex16.F

<400>  115
tctccaactt aaaggggaaa aag                                               23


<210>  116
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex16.R

<400>  116
gcttgtgctt ccgttcttg                                                    19


<210>  117
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex17.F

<400>  117
ggaaatgtgg ctgcaacttc                                                   20


<210>  118
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex17.R

<400>  118
tggcaagaca caacaataag g                                                 21


<210>  119
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex18.F

<400>  119
tgctttgtag aatgtgatgt tttc                                              24


<210>  120
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex18.R

<400>  120
gggaaaagac cctaccttgg                                                   20


<210>  121
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex19.F

<400>  121
gggatctttt ctctgagagg ttc                                               23


<210>  122
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex19.R

<400>  122
aaatgaactt aattccagag aacg                                              24


<210>  123
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex20.F

<400>  123
tctgttctct tgggagttgg                                                   20


<210>  124
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex20.R

<400>  124
accatgcctg gctgaatg                                                     18


<210>  125
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex21.F

<400>  125
tttcccagag aagagaatga gg                                                22


<210>  126
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex21.R

<400>  126
caaatggcac tttcttcaag g                                                 21


<210>  127
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex22A1.F

<400>  127
tctgaagcag ggacagtgtg                                                   20


<210>  128
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex22A1.R

<400>  128
tttatccagc cttgggtcag                                                   20


<210>  129
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex22B1.F

<400>  129
aatcccaatc cttggtttcc                                                   20


<210>  130
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex22B1.R

<400>  130
tcttcctgag gcctgagttg                                                   20


<210>  131
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex22C1.F

<400>  131
tgagaagatg ccagtgttgg                                                   20


<210>  132
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer NSD1.ex22C1.R

<400>  132
ttctgagtgt tgggatatga gg                                                22


<210>  133
<211>  39
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 2

<400>  133

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys 
        35                  


<210>  134
<211>  43
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 3

<400>  134

Ser Met Phe Ser Ser Asn Arg Gln Lys Ile Leu Glu Arg Thr Glu Ile 
1               5                   10                  15      


Leu Asn Gln Glu Trp Lys Gln Arg Arg Ile Gln Pro Val His Ile Leu 
            20                  25                  30          


Thr Ser Val Ser Ser Leu Arg Gly Thr Arg Glu 
        35                  40              


<210>  135
<211>  39
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 4

<400>  135

Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile Pro Leu 
1               5                   10                  15      


Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser Trp Ser 
            20                  25                  30          


Pro Leu Gln Gln Asn Phe Met 
        35                  


<210>  136
<211>  40
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 5

<400>  136

Val Glu Asp Glu Thr Val Leu His Asn Ile Pro Tyr Met Gly Asp Glu 
1               5                   10                  15      


Val Leu Asp Gln Asp Gly Thr Phe Ile Glu Glu Leu Ile Lys Asn Tyr 
            20                  25                  30          


Asp Gly Lys Val His Gly Asp Arg 
        35                  40  


<210>  137
<211>  48
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 6

<400>  137

Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn Ala 
1               5                   10                  15      


Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp Pro 
            20                  25                  30          


Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp Asp 
        35                  40                  45              


<210>  138
<211>  34
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 7

<400>  138

Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe Glu 
1               5                   10                  15      


Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu Lys 
            20                  25                  30          


Glu Lys 
        


<210>  139
<211>  60
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 8

<400>  139

Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu Pro Pro Glu 
1               5                   10                  15      


Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val Gln Arg Glu 
            20                  25                  30          


Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg Cys Phe Lys 
        35                  40                  45              


Tyr Asp Cys Phe Leu His Arg Lys Cys Asn Tyr Ser 
    50                  55                  60  


<210>  140
<211>  30
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 9

<400>  140

Phe His Ala Thr Pro Asn Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala 
1               5                   10                  15      


Leu Asp Asn Lys Pro Cys Gly Pro Gln Cys Tyr Gln His Leu 
            20                  25                  30  


<210>  141
<211>  81
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 10

<400>  141

Glu Gly Ala Lys Glu Phe Ala Ala Ala Leu Thr Ala Glu Arg Ile Lys 
1               5                   10                  15      


Thr Pro Pro Lys Arg Pro Gly Gly Arg Arg Arg Gly Arg Leu Pro Asn 
            20                  25                  30          


Asn Ser Ser Arg Pro Ser Thr Pro Thr Ile Asn Val Leu Glu Ser Lys 
        35                  40                  45              


Asp Thr Asp Ser Asp Arg Glu Ala Gly Thr Glu Thr Gly Gly Glu Asn 
    50                  55                  60                  


Asn Asp Lys Glu Glu Glu Glu Lys Lys Asp Glu Thr Ser Ser Ser Ser 
65                  70                  75                  80  


Glu 
    


<210>  142
<211>  56
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 11

<400>  142

Ala Asn Ser Arg Cys Gln Thr Pro Ile Lys Met Lys Pro Asn Ile Glu 
1               5                   10                  15      


Pro Pro Glu Asn Val Glu Trp Ser Gly Ala Glu Ala Ser Met Phe Arg 
            20                  25                  30          


Val Leu Ile Gly Thr Tyr Tyr Asp Asn Phe Cys Ala Ile Ala Arg Leu 
        35                  40                  45              


Ile Gly Thr Lys Thr Cys Arg Gln 
    50                  55      


<210>  143
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 12

<400>  143

Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala Pro 
1               5                   10                  15      


Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His Arg 
            20                  25                  30          


<210>  144
<211>  14
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 13

<400>  144

Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp 
1               5                   10                  


<210>  145
<211>  42
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 14

<400>  145

Gly Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg 
1               5                   10                  15      


Gln Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys 
            20                  25                  30          


Glu Lys Phe Cys Gln Cys Ser Ser Glu Cys 
        35                  40          


<210>  146
<211>  59
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 15

<400>  146

Gln Asn Arg Phe Pro Gly Cys Arg Cys Lys Ala Gln Cys Asn Thr Lys 
1               5                   10                  15      


Gln Cys Pro Cys Tyr Leu Ala Val Arg Glu Cys Asp Pro Asp Leu Cys 
            20                  25                  30          


Leu Thr Cys Gly Ala Ala Asp His Trp Asp Ser Lys Asn Val Ser Cys 
        35                  40                  45              


Lys Asn Cys Ser Ile Gln Arg Gly Ser Lys Lys 
    50                  55                  


<210>  147
<211>  32
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 16

<400>  147

His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp Gly Ile Phe Ile 
1               5                   10                  15      


Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu Tyr Cys Gly Glu 
            20                  25                  30          


<210>  148
<211>  27
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 17

<400>  148

Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys Val Tyr Asp Lys 
1               5                   10                  15      


Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn 
            20                  25          


<210>  149
<211>  27
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 18

<400>  149

Asp Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala 
1               5                   10                  15      


Asn His Ser Val Asn Pro Asn Cys Tyr Ala Lys 
            20                  25          


<210>  150
<211>  29
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 19

<400>  150

Val Met Met Val Asn Gly Asp His Arg Ile Gly Ile Phe Ala Lys Arg 
1               5                   10                  15      


Ala Ile Gln Thr Gly Glu Glu Leu Phe Phe Asp Tyr Arg 
            20                  25                  


<210>  151
<211>  19
<212>  PRT
<213>  Homo sapiens

<220>
<223>  amino acid sequence encoded by exon 20

<400>  151

Tyr Ser Gln Ala Asp Ala Leu Lys Tyr Val Gly Ile Glu Arg Glu Met 
1               5                   10                  15      


Glu Ile Pro 
            


