                         SEQUENCE LISTING

<110>  aTyr Pharma Inc.
 
<120>  PEGYLATED ASPARTYL-tRNA SYNTHETASE POLYPEPTIDES

<130>  ATYR-108/01WO

<150>  US 61/567,602
<151>  2011-12-06

<160>  198   

<170>  PatentIn version 3.5

<210>  1
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  2
<211>  1506
<212>  DNA
<213>  Homo sapiens

<400>  2
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat gtgagccatt caaatttttg     1020

gagccaactc taagactaga atattgtgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

ccttag                                                                1506


<210>  3
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
145                 150                 


<210>  4
<211>  171
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg 
                165                 170     


<210>  5
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val 
                165                 170                 


<210>  6
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn 
            180         


<210>  7
<211>  184
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val 
            180                 


<210>  8
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala 
        


<210>  9
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


<210>  10
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile 
1               5                   10                  15      


Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser 
            20                  25                  30          


Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe 
        35                  40                  45              


Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met 
    50                  55                  60                  


Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu 
65                  70                  75                  80  


Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln 
                85                  90                  95      


Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu 
            100                 105                 110         


Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala Glu 
        115                 120                 125             


Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu Asp 
    130                 135                 140                 


Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe Arg 
145                 150                 155                 160 


Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn Lys 
                165                 170                 175     


Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser Glu 
            180                 185                 190         


Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala Tyr 
        195                 200                 205             


Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala Asp 
    210                 215                 220                 


Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp Ser 
225                 230                 235                 240 


Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu 
                245                 250                 255 


<210>  11
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln 
1               5                   10                  15      


Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln 
            20                  25                  30          


Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg 
        35                  40                  45              


Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn 
    50                  55                  60                  


Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val 
65                  70                  75                  80  


Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly 
                85                  90                  95      


Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp 
            100                 105                 110         


Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro 
        115                 120                 125             


Arg Leu Pro Leu 
    130         


<210>  12
<211>  122
<212>  PRT
<213>  Homo sapiens

<400>  12

Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
1               5                   10                  15      


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
            20                  25                  30          


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
        35                  40                  45              


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
    50                  55                  60                  


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
65                  70                  75                  80  


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
                85                  90                  95      


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
            100                 105                 110         


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
        115                 120         


<210>  13
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  13

Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp Thr Met Val Gln 
1               5                   10                  15      


Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu Ile Gln Thr Val 
            20                  25                  30          


Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu Glu Pro Thr Leu 
        35                  40                  45              


Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg Glu Ala Gly Val 
    50                  55                  60                  


Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn Glu Lys Leu Leu 
65                  70                  75                  80  


Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe Tyr Ile Leu Asp 
                85                  90                  95      


Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met Pro Asp Pro Arg 
            100                 105                 110         


Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met Arg Gly Glu Glu 
        115                 120                 125             


Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln Leu Leu Thr Glu 
    130                 135                 140                 


Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile Lys Ala Tyr Ile 
145                 150                 155                 160 


Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly Gly Gly Ile Gly 
                165                 170                 175     


Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His Asn Val Arg Gln 
            180                 185                 190         


Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr Pro 
        195                 200                 205 


<210>  14
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val 
1               5                   10                  15      


Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln 
            20                  25                  30          


Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala 
        35                  40                  45              


Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala 
    50                  55                  60                  


Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu 
65                  70                  75                  80  


Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe 
                85                  90                  95      


Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn 
            100                 105                 110         


Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser 
        115                 120                 125             


Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala 
    130                 135                 140                 


Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala 
145                 150                 155                 160 


Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp 
                165                 170                 175     


Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu 
            180                 185                 190         


Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp 
        195                 200                 205             


Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu 
    210                 215                 220                 


Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu 
225                 230                 235                 240 


Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg 
                245                 250                 255     


Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn 
            260                 265                 270         


Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe 
        275                 280                 285             


Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met 
    290                 295                 300                 


Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met 
305                 310                 315                 320 


Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln 
                325                 330                 335     


Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile 
            340                 345                 350         


Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly 
        355                 360                 365             


Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His 
    370                 375                 380                 


Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr 
385                 390                 395                 400 


Pro 
    


<210>  15
<211>  470
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Gly Lys Gln Cys Phe Leu Val 
        35                  40                  45              


Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp 
    50                  55                  60                  


His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu 
65                  70                  75                  80  


Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile 
                85                  90                  95      


Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr 
            100                 105                 110         


Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala 
        115                 120                 125             


Val Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn 
    130                 135                 140                 


Gln Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr 
145                 150                 155                 160 


Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg 
                165                 170                 175     


Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile 
            180                 185                 190         


Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr 
        195                 200                 205             


Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln 
    210                 215                 220                 


Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val 
225                 230                 235                 240 


Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val 
                245                 250                 255     


Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met 
            260                 265                 270         


Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu 
        275                 280                 285             


Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu 
    290                 295                 300                 


Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala 
305                 310                 315                 320 


Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp 
                325                 330                 335     


Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys 
            340                 345                 350         


Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg 
        355                 360                 365             


Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser 
    370                 375                 380                 


Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg 
385                 390                 395                 400 


Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile 
                405                 410                 415     


Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala 
            420                 425                 430         


Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu 
        435                 440                 445             


Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp 
    450                 455                 460                 


Pro Lys Arg Leu Thr Pro 
465                 470 


<210>  16
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Thr Ser Thr 
    130                 135                 140                 


Ser Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg 
145                 150                 155                 160 


Glu Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile 
                165                 170                 175     


Ile Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr 
            180                 185                 190         


Phe Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln 
        195                 200                 205             


Met Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val 
    210                 215                 220                 


Phe Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val 
225                 230                 235                 240 


Gly Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met 
                245                 250                 255     


Glu Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu 
            260                 265                 270         


Arg Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu 
        275                 280                 285             


Pro Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala 
    290                 295                 300                 


Leu Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp 
305                 310                 315                 320 


Leu Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys 
                325                 330                 335     


Tyr Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg 
            340                 345                 350         


Pro Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser 
        355                 360                 365             


Tyr Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg 
    370                 375                 380                 


Ile His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile 
385                 390                 395                 400 


Asp Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala 
                405                 410                 415     


Pro Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu 
            420                 425                 430         


Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp 
        435                 440                 445             


Pro Lys Arg Leu Thr Pro 
    450                 


<210>  17
<211>  452
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Ser 
305                 310                 315                 320 


Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp 
                325                 330                 335     


Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe 
            340                 345                 350         


Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp 
        355                 360                 365             


Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His 
    370                 375                 380                 


Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu 
385                 390                 395                 400 


Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro 
                405                 410                 415     


His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu 
            420                 425                 430         


Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys 
        435                 440                 445             


Arg Leu Thr Pro 
    450         


<210>  18
<211>  85
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Trp Asn Glu Leu Leu Cys Cys Phe Trp 
            20                  25                  30          


Asp Cys Ile Met Phe Val Arg Pro Pro Cys Ser Leu Val Ile Pro Asn 
        35                  40                  45              


Asp Ser Leu Leu Lys Phe Thr Leu Cys His Leu Thr Pro Val Trp Met 
    50                  55                  60                  


Thr Glu Arg Asp Pro Ala Ser Lys Lys Lys Lys Lys Lys Glu Ser His 
65                  70                  75                  80  


Thr Tyr Ser Phe Gln 
                85  


<210>  19
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Gly Asn Ser Ala Ser 
            20                  25          


<210>  20
<211>  401
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val 
1               5                   10                  15      


Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln 
            20                  25                  30          


Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala 
        35                  40                  45              


Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val Arg Pro Glu Ala 
    50                  55                  60                  


Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln Asp Thr Arg Leu 
65                  70                  75                  80  


Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser Gln Ala Val Phe 
                85                  90                  95      


Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu Thr Leu Ile Asn 
            100                 105                 110         


Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile Ser Ala Ala Ser 
        115                 120                 125             


Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe Lys Asn Asn Ala 
    130                 135                 140                 


Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met Cys Ile Cys Ala 
145                 150                 155                 160 


Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe Arg Ala Glu Asp 
                165                 170                 175     


Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly Leu Asp Ile Glu 
            180                 185                 190         


Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu Glu Ile Ala Asp 
        195                 200                 205             


Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg Phe Gln Thr Glu 
    210                 215                 220                 


Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro Phe Lys Phe Leu 
225                 230                 235                 240 


Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu Ala Met Leu Arg 
                245                 250                 255     


Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu Ser Thr Pro Asn 
            260                 265                 270         


Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr Asp Thr Asp Phe 
        275                 280                 285             


Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro Phe Tyr Thr Met 
    290                 295                 300                 


Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr Asp Met Phe Met 
305                 310                 315                 320 


Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile His Asp Pro Gln 
                325                 330                 335     


Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp Leu Glu Lys Ile 
            340                 345                 350         


Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro Pro His Ala Gly 
        355                 360                 365             


Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe Leu Gly Leu His 
    370                 375                 380                 


Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro Lys Arg Leu Thr 
385                 390                 395                 400 


Pro 
    


<210>  21
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Leu Phe Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro 
1               5                   10                  15      


Arg Asp Pro Lys Arg Leu Thr Pro 
            20                  


<210>  22
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  22

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Ser Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
145                 150                 


<210>  23
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypetide variant with reduced cysteine content

<400>  23

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Ser Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
145                 150                 


<210>  24
<211>  154
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  24

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Ser Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Ser Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
145                 150                 


<210>  25
<211>  462
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimizedversion of the wild type AspRS1N1 polypeptide

<400>  25
atgccgagcg cgagcgccag ccgtaagagc caggaaaaac cacgtgagat tatggatgcc       60

gcagaggact atgcgaaaga acgttacggt atttccagca tgatccaatc tcaggagaaa      120

ccggaccgcg ttctggttcg tgttcgcgat ctgaccattc agaaggcgga cgaggtggtt      180

tgggtgcgtg cgcgcgtgca caccagccgt gcaaaaggca aacagtgctt tctggtcctg      240

cgtcagcagc aattcaacgt ccaggcgctg gtggcagtgg gtgaccacgc cagcaaacaa      300

atggtgaagt tcgctgctaa catcaataaa gaatccattg ttgatgttga aggcgtcgtt      360

cgcaaggtca atcaaaagat cggctcgtgt acgcaacaag atgtcgagct gcatgtgcag      420

aagatttacg tcatcagcct ggcggagccg cgtttgccgc tg                         462


<210>  26
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of the wild type AspRS1N1 polypeptide

<400>  26
atgccgagcg cgagcgccag ccgtaagagc caggaaaaac cacgtgagat tatggatgcc       60

gcagaggact atgcgaaaga acgttacggt atttccagca tgatccaatc tcaggagaaa      120

ccggaccgcg ttctggttcg tgttcgcgat ctgaccattc agaaggcgga cgaggtggtt      180

tgggtgcgtg cgcgcgtgca caccagccgt gcaaaaggca aacagagctt tctggtcctg      240

cgtcagcagc aattcaacgt ccaggcgctg gtggcagtgg gtgaccacgc cagcaaacaa      300

atggtgaagt tcgctgctaa catcaataaa gaatccattg ttgatgttga aggcgtcgtt      360

cgcaaggtca atcaaaagat cggctcgtgt acgcaacaag atgtcgagct gcatgtgcag      420

aagatttacg tcatcagcct ggcggagccg cgtttgccgc tgggtaagcc gatccctaac      480

ccgctgttgg gtctggacag cacgcatcac catcaccacc actaa                      525


<210>  27
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon optimized version of the wild type full length DRS 
       polypeptide

<400>  27
atgccatcag cctcagcatc tcgtaaaagc caggaaaaac cgcgcgaaat catggacgct       60

gccgaagatt atgccaaaga gcgctatggt atcagttcga tgatccagtc acaagagaaa      120

ccagatcgtg tgctggtccg tgttcgtgac ctgaccatcc agaaagcgga tgaagttgtt      180

tgggtccgtg ctcgtgttca tacaagccgt gccaaaggca aacagtgctt cctggttctg      240

cgtcaacagc agtttaacgt tcaggccctg gtagccgttg gtgatcacgc ctcaaaacaa      300

atggtgaaat tcgccgccaa catcaacaaa gagagcatcg tcgacgttga aggtgtcgtc      360

cgtaaagtga atcagaaaat cggctcctgt acacagcaag atgtggagct gcatgtccaa      420

aaaatctatg tcatctcact ggccgaacct cgtctgcctc tgcaactgga tgatgctgta      480

cgccctgaag ctgaaggcga agaagaaggt cgtgctacgg ttaatcagga tactcgcctg      540

gacaaccgtg tcattgatct gcgcacctca acctctcaag cggtattccg cctgcaatcc      600

ggcatctgtc acctgttccg tgaaacgctg atcaacaaag ggtttgtgga gattcagacc      660

ccgaaaatca ttagtgccgc cagcgaaggt ggagcaaatg tgtttaccgt gtcctatttc      720

aaaaacaatg cctatctggc acagtctcct cagctgtata aacaaatgtg tatctgtgct      780

gacttcgaga aagtgttctc aatcgggccg gtattccgtg cagaggatag caacacacac      840

cgccatctga ccgaatttgt aggcctggac atcgaaatgg ccttcaacta tcattatcac      900

gaggtgatgg aagaaatcgc tgatacaatg gtacagatct ttaaagggct gcaagaacgc      960

tttcaaacag agattcaaac cgtcaataaa cagttcccgt gtgaaccgtt caaatttctg     1020

gaaccgaccc tgcgtctgga atattgtgaa gcactggcta tgctgcgcga agctggtgtc     1080

gaaatgggtg atgaggatga cctgtctacc cctaacgaaa aactgctggg ccacctggta     1140

aaagaaaaat atgacacaga cttctatatc ctggacaaat atccgctggc agttcgtccg     1200

ttttatacga tgcctgatcc tcgtaatccg aaacaaagca actcctatga catgttcatg     1260

cgtggtgaag agatcctgtc tggtgctcaa cgtatccatg atccacagct gctgacagaa     1320

cgtgcactgc atcacggtat tgatctggag aaaatcaaag cctatatcga ctcctttcgc     1380

tttggtgccc ctccacatgc cggtggtgga attgggctgg agcgtgtaac aatgctgttc     1440

ctgggactgc acaacgtccg tcaaacctca atgtttccac gtgaccctaa acgtctgaca     1500

cct                                                                   1503


<210>  28
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  An E.coli codon optimized nucleic acid sequence encoding the DRS 
       polypeptide AspRS1N1

<400>  28
atgccgagcg cgagcgccag ccgtaagagc caggaaaaac cacgtgagat tatggatgcc       60

gcagaggact atgcgaaaga acgttacggt atttccagca tgatccaatc tcaggagaaa      120

ccggaccgcg ttctggttcg tgttcgcgat ctgaccattc agaaggcgga cgaggtggtt      180

tgggtgcgtg cgcgcgtgca caccagccgt gcaaaaggca aacagagctt tctggtcctg      240

cgtcagcagc aattcaacgt ccaggcgctg gtggcagtgg gtgaccacgc cagcaaacaa      300

atggtgaagt tcgctgctaa catcaataaa gaatccattg ttgatgttga aggcgtcgtt      360

cgcaaggtca atcaaaagat cggctcgtgt acgcaacaag atgtcgagct gcatgtgcag      420

aagatttacg tcatcagcct ggcggagccg cgtttgccgc tgggtaagcc gatccctaac      480

ccgctgttgg gtctggacag cacgcatcac catcaccacc actaa                      525


<210>  29
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Traqnslated protein of the E.coli codon optimized nucleic acid 
       sequence encoding the DRS polypeptide AspRS1N1

<400>  29

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Ser Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gly Lys Pro Ile Pro Asn 
145                 150                 155                 160 


Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His 
                165                 170                 


<210>  30
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  The nucleic acid sequence of the native AspRS1N1 cloned into the 
       identical expression cassette

<400>  30
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgggtaagcc tatccctaac      480

cctctcctcg gtctcgattc tacgcaccac caccaccacc actga                      525


<210>  31
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  the non-mutated AspRS1N1 protein with C-terminal tag

<400>  31

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gly Lys Pro Ile Pro Asn 
145                 150                 155                 160 


Pro Leu Leu Gly Leu Asp Ser Thr His His His His His His 
                165                 170                 


<210>  32
<211>  45
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  Primer

<400>  32
agtcttgcac ttgtcacgaa ttcgatgccc agcgccagcg ccagc                       45


<210>  33
<211>  75
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(75)
<223>  Primer

<400>  33
cggtgggcat gtgtgagttt tgtctcactt gtcgtcatcg tctttgtagt ccgtagaatc       60

gagaccgagg agagg                                                        75


<210>  34
<211>  45
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(45)
<223>  Primer

<400>  34
gatcaccggc gaaggagggc caccatgccc agcgccagcg ccagc                       45


<210>  35
<211>  75
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(75)
<223>  Primer

<400>  35
cggtgggcat gtgtgagttt tgtctcactt gtcgtcatcg tctttgtagt ccgtagaatc       60

gagaccgagg agagg                                                        75


<210>  36
<211>  591
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  secretory AspRS1N1 sequence

<400>  36
atgtacagga tgcaactcct gtcttgcatt gcactaagtc ttgcacttgt cacgaattcg       60

atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg      120

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      180

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      240

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      300

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      360

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      420

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      480

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgggtaagcc tatccctaac      540

cctctcctcg gtctcgattc tacggactac aaagacgatg acgacaagtg a               591


<210>  37
<211>  531
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  intracellular AspRS1N1 sequence

<400>  37
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgggtaagcc tatccctaac      480

cctctcctcg gtctcgattc tacggactac aaagacgatg acgacaagtg a               531


<210>  38
<211>  37
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  Human C76X Primer

<400>  38
gctaaaggga aacagagctt cttagtccta cgtcagc                                37


<210>  39
<211>  37
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(37)
<223>  Human C130X Primer

<400>  39
gtgaatcaga aaattggaag cagcacacag caagacg                                37


<210>  40
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E.coli codon optimized C76X Primer

<400>  40
cgtgcaaaag gcaaacagag ctttctggtc ctgcgtcagc                             40


<210>  41
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  E.coli codon optimized C130X Primer

<400>  41
caatcaaaag atcggctcga gcacgcaaca agatgtcgag c                           41


<210>  42
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  42

His Ile Gly His 
1               


<210>  43
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Met Ser Lys Ser 
1               5   


<210>  44
<211>  18
<212>  DNA
<213>  Homo sapiens

<400>  44
actttttgat ggggttgt                                                     18


<210>  45
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  45
cctttttcat gggcttgttt ttttcttgta aatttgttt                              39


<210>  46
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin-cleavable amino acid linker sequence

<400>  46

Gly Arg Gly Asp 
1               


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin-cleavable amino acid linker sequence

<400>  47

Gly Arg Gly Asp Asn Pro 
1               5       


<210>  48
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin-cleavable amino acid linker sequence

<400>  48

Gly Arg Gly Asp Ser 
1               5   


<210>  49
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Thrombin-cleavable amino acid linker sequence

<400>  49

Gly Arg Gly Asp Ser Pro Lys 
1               5           


<210>  50
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase-cleavable amino acid linker sequence

<400>  50

Ala Ala Pro Val 
1               


<210>  51
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase-cleavable amino acid linker sequence

<400>  51

Ala Ala Pro Leu 
1               


<210>  52
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase-cleavable amino acid linker sequence

<400>  52

Ala Ala Pro Phe 
1               


<210>  53
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase-cleavable amino acid linker sequence

<400>  53

Ala Ala Pro Ala 
1               


<210>  54
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Elastase-cleavable amino acid linker sequence

<400>  54

Ala Tyr Leu Val 
1               


<210>  55
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase-cleavable amino acid linker sequence


<220>
<221>  VARIANT
<222>  (3)..(3)
<223>  Xaa = Any amino acid

<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any Amino Acid

<400>  55

Gly Pro Xaa Gly Pro Xaa 
1               5       


<210>  56
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase-cleavable amino acid linker sequence


<220>
<221>  VARIANT
<222>  (4)..(4)
<223>  Xaa = Any Amino Acid

<400>  56

Leu Gly Pro Xaa 
1               


<210>  57
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase-cleavable amino acid linker sequence


<220>
<221>  VARIANT
<222>  (6)..(6)
<223>  Xaa = Any Amino Acid

<400>  57

Gly Pro Ile Gly Pro Xaa 
1               5       


<210>  58
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Matrix metalloproteinase-cleavable amino acid linker sequence


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Any Amino Acid

<400>  58

Ala Pro Gly Leu Xaa 
1               5   


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence


<220>
<221>  VARIANT
<222>  (5)..(5)
<223>  Xaa = Any Amino Acid

<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any Amino Acid

<400>  59

Pro Leu Gly Pro Xaa Arg Xaa 
1               5           


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence


<220>
<221>  VARIANT
<222>  (7)..(7)
<223>  Xaa = Any Amino Acid

<400>  60

Pro Leu Gly Leu Leu Gly Xaa 
1               5           


<210>  61
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence

<400>  61

Pro Gln Gly Ile Ala Gly Trp 
1               5           


<210>  62
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence

<400>  62

Pro Leu Gly Cys His 
1               5   


<210>  63
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence

<400>  63

Pro Leu Gly Leu Tyr Ala 
1               5       


<210>  64
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence

<400>  64

Pro Leu Ala Leu Trp Ala Arg 
1               5           


<210>  65
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Collagenase-cleavable amino acid linker sequence

<400>  65

Pro Leu Ala Tyr Trp Ala Arg 
1               5           


<210>  66
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stromelysin-cleavable amino acid linker sequence

<400>  66

Pro Tyr Ala Tyr Tyr Met Arg 
1               5           


<210>  67
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gelatinase-cleavable amino acid linker sequence

<400>  67

Pro Leu Gly Met Tyr Ser Arg 
1               5           


<210>  68
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme-cleavable amino acid linker 
       sequence

<400>  68

Gly Asp Lys Pro 
1               


<210>  69
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Angiotensin converting enzyme-cleavable amino acid linker 
       sequence

<400>  69

Gly Ser Asp Lys Pro 
1               5   


<210>  70
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B-cleavable amino acid linker sequence

<400>  70

Ala Leu Ala Leu 
1               


<210>  71
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Cathepsin B-cleavable amino acid linker sequence

<400>  71

Gly Phe Leu Gly 
1               


<210>  72
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  V5 tag sequence

<400>  72

Gly Lys Pro Ile Pro Asn Pro Leu Leu Gly Leu Asp Ser Thr 
1               5                   10                  


<210>  73
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag sequence

<400>  73

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  74
<211>  182
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn 
            180         


<210>  75
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  75

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu 
            180 


<210>  76
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr 
        


<210>  77
<211>  176
<212>  PRT
<213>  Homo sapiens

<400>  77

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


<210>  78
<211>  174
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val 
                165                 170                 


<210>  79
<211>  172
<212>  PRT
<213>  Homo sapiens

<400>  79

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala 
                165                 170         


<210>  80
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly 
                165                 170 


<210>  81
<211>  168
<212>  PRT
<213>  Homo sapiens

<400>  81

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu 
                165             


<210>  82
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly 
                165     


<210>  83
<211>  164
<212>  PRT
<213>  Homo sapiens

<400>  83

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala 
                


<210>  84
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro 
        


<210>  85
<211>  160
<212>  PRT
<213>  Homo sapiens

<400>  85

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


<210>  86
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp 
145                 150                 155             


<210>  87
<211>  156
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu 
145                 150                 155     


<210>  88
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
145                 150                 


<210>  89
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu 
145                 150         


<210>  90
<211>  150
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro 
145                 150 


<210>  91
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala 
145             


<210>  92
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser 
145     


<210>  93
<211>  151
<212>  PRT
<213>  Homo sapiens

<400>  93

Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu Ile Met Asp 
1               5                   10                  15      


Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile 
            20                  25                  30          


Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu 
        35                  40                  45              


Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His 
    50                  55                  60                  


Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln 
65                  70                  75                  80  


Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys 
                85                  90                  95      


Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp 
            100                 105                 110         


Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr 
        115                 120                 125             


Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu 
    130                 135                 140                 


Ala Glu Pro Arg Leu Pro Leu 
145                 150     


<210>  94
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  94

Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala 
1               5                   10                  15      


Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser 
            20                  25                  30          


Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile 
        35                  40                  45              


Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser 
    50                  55                  60                  


Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe 
65                  70                  75                  80  


Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met 
                85                  90                  95      


Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu 
            100                 105                 110         


Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln 
        115                 120                 125             


Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu 
    130                 135                 140                 


Pro Arg Leu Pro Leu 
145                 


<210>  95
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  95

Arg Lys Ser Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp 
1               5                   10                  15      


Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu 
            20                  25                  30          


Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys 
        35                  40                  45              


Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala 
    50                  55                  60                  


Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val 
65                  70                  75                  80  


Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys 
                85                  90                  95      


Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val 
            100                 105                 110         


Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val 
        115                 120                 125             


Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg 
    130                 135                 140                 


Leu Pro Leu 
145         


<210>  96
<211>  145
<212>  PRT
<213>  Homo sapiens

<400>  96

Ser Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala 
1               5                   10                  15      


Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro 
            20                  25                  30          


Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp 
        35                  40                  45              


Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly 
    50                  55                  60                  


Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala 
65                  70                  75                  80  


Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala 
                85                  90                  95      


Ala Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg 
            100                 105                 110         


Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu 
        115                 120                 125             


His Val Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro 
    130                 135                 140                 


Leu 
145 


<210>  97
<211>  143
<212>  PRT
<213>  Homo sapiens

<400>  97

Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu 
1               5                   10                  15      


Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg 
            20                  25                  30          


Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val 
        35                  40                  45              


Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln 
    50                  55                  60                  


Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val 
65                  70                  75                  80  


Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn 
                85                  90                  95      


Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val 
            100                 105                 110         


Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val 
        115                 120                 125             


Gln Lys Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
    130                 135                 140             


<210>  98
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  98

Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr 
1               5                   10                  15      


Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu 
            20                  25                  30          


Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp 
        35                  40                  45              


Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe 
    50                  55                  60                  


Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val 
65                  70                  75                  80  


Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn 
                85                  90                  95      


Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln 
            100                 105                 110         


Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys 
        115                 120                 125             


Ile Tyr Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
    130                 135                 140     


<210>  99
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  99

Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile 
1               5                   10                  15      


Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg 
            20                  25                  30          


Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg 
        35                  40                  45              


Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val 
    50                  55                  60                  


Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp 
65                  70                  75                  80  


His Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu 
                85                  90                  95      


Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile 
            100                 105                 110         


Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr 
        115                 120                 125             


Val Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu 
    130                 135                 


<210>  100
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser 
1               5                   10                  15      


Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg 
            20                  25                  30          


Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg 
        35                  40                  45              


Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg 
    50                  55                  60                  


Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala 
65                  70                  75                  80  


Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile 
                85                  90                  95      


Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser 
            100                 105                 110         


Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile 
        115                 120                 125             


Ser Leu Ala Glu Pro Arg Leu Pro Leu 
    130                 135         


<210>  101
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser 
1               5                   10                  15      


Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg 
            20                  25                  30          


Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg 
        35                  40                  45              


Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg 
    50                  55                  60                  


Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala 
65                  70                  75                  80  


Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile 
                85                  90                  95      


Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser 
            100                 105                 110         


Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile 
        115                 120                 125             


Ser Leu Ala Glu Pro Arg Leu 
    130                 135 


<210>  102
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser 
1               5                   10                  15      


Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg 
            20                  25                  30          


Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg 
        35                  40                  45              


Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg 
    50                  55                  60                  


Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala 
65                  70                  75                  80  


Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile 
                85                  90                  95      


Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser 
            100                 105                 110         


Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile 
        115                 120                 125             


Ser Leu Ala Glu Pro Arg Leu 
    130                 135 


<210>  103
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  103

Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile 
1               5                   10                  15      


Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu 
            20                  25                  30          


Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His 
        35                  40                  45              


Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln 
    50                  55                  60                  


Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys 
65                  70                  75                  80  


Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser Ile Val Asp 
                85                  90                  95      


Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr 
            100                 105                 110         


Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser Leu 
        115                 120                 125             


Ala Glu Pro Arg Leu 
    130             


<210>  104
<211>  137
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Gln Glu Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala 
1               5                   10                  15      


Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro 
            20                  25                  30          


Asp Arg Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp 
        35                  40                  45              


Glu Val Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly 
    50                  55                  60                  


Lys Gln Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala 
65                  70                  75                  80  


Leu Val Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala 
                85                  90                  95      


Cys Asn Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg 
            100                 105                 110         


Lys Val Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu 
        115                 120                 125             


His Val Gln Lys Ile Tyr Val Ile Ser 
    130                 135         


<210>  105
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu 
1               5                   10                  15      


Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg 
            20                  25                  30          


Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val 
        35                  40                  45              


Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln 
    50                  55                  60                  


Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val 
65                  70                  75                  80  


Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Cys Asn 
                85                  90                  95      


Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val 
            100                 105                 110         


Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val 
        115                 120                 125             


Gln Lys Ile Tyr Val Ile Ser 
    130                 135 


<210>  106
<211>  135
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Lys Pro Arg Glu Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu 
1               5                   10                  15      


Arg Tyr Gly Ile Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg 
            20                  25                  30          


Val Leu Val Arg Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val 
        35                  40                  45              


Val Trp Val Arg Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln 
    50                  55                  60                  


Cys Phe Leu Val Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val 
65                  70                  75                  80  


Ala Val Gly Asp His Ala Ser Lys Gln Met Val Lys Phe Ala Cys Asn 
                85                  90                  95      


Ile Asn Lys Glu Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val 
            100                 105                 110         


Asn Gln Lys Ile Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val 
        115                 120                 125             


Gln Lys Ile Tyr Val Ile Ser 
    130                 135 


<210>  107
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile 
1               5                   10                  15      


Ser Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg 
            20                  25                  30          


Val Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg 
        35                  40                  45              


Ala Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val 
    50                  55                  60                  


Leu Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp 
65                  70                  75                  80  


His Ala Ser Lys Gln Met Val Lys Phe Ala Cys Asn Ile Asn Lys Glu 
                85                  90                  95      


Ser Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile 
            100                 105                 110         


Gly Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr 
        115                 120                 125             


Val Ile Ser 
    130     


<210>  108
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser Ser Met Ile 
1               5                   10                  15      


Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val Arg Asp Leu 
            20                  25                  30          


Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala Arg Val His 
        35                  40                  45              


Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu Arg Gln Gln 
    50                  55                  60                  


Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His Ala Ser Lys 
65                  70                  75                  80  


Gln Met Val Lys Phe Ala Cys Asn Ile Asn Lys Glu Ser Ile Val Asp 
                85                  90                  95      


Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly Ser Cys Thr 
            100                 105                 110         


Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val Ile Ser 
        115                 120                 125         


<210>  109
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  109

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Ser Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  110
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  110

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Ser Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  111
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  111

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Cys His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Ser Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Ser Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  112
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  112

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Ala His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  113
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  113

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Val His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Cys Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Cys Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  114
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  114

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Ala His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Cys Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Ser Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Ser Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  115
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  115

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Val His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Ala Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Ser Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Ser Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  116
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DRS polypeptide variant with reduced cysteine content

<400>  116

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Ala His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Ala Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Ser Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Ser Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  117
<211>  501
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  RS polypeptide variant with reduced cysteine content

<400>  117

Met Pro Ser Ala Ser Ala Ser Arg Lys Ser Gln Glu Lys Pro Arg Glu 
1               5                   10                  15      


Ile Met Asp Ala Ala Glu Asp Tyr Ala Lys Glu Arg Tyr Gly Ile Ser 
            20                  25                  30          


Ser Met Ile Gln Ser Gln Glu Lys Pro Asp Arg Val Leu Val Arg Val 
        35                  40                  45              


Arg Asp Leu Thr Ile Gln Lys Ala Asp Glu Val Val Trp Val Arg Ala 
    50                  55                  60                  


Arg Val His Thr Ser Arg Ala Lys Gly Lys Gln Cys Phe Leu Val Leu 
65                  70                  75                  80  


Arg Gln Gln Gln Phe Asn Val Gln Ala Leu Val Ala Val Gly Asp His 
                85                  90                  95      


Ala Ser Lys Gln Met Val Lys Phe Ala Ala Asn Ile Asn Lys Glu Ser 
            100                 105                 110         


Ile Val Asp Val Glu Gly Val Val Arg Lys Val Asn Gln Lys Ile Gly 
        115                 120                 125             


Ser Cys Thr Gln Gln Asp Val Glu Leu His Val Gln Lys Ile Tyr Val 
    130                 135                 140                 


Ile Ser Leu Ala Glu Pro Arg Leu Pro Leu Gln Leu Asp Asp Ala Val 
145                 150                 155                 160 


Arg Pro Glu Ala Glu Gly Glu Glu Glu Gly Arg Ala Thr Val Asn Gln 
                165                 170                 175     


Asp Thr Arg Leu Asp Asn Arg Val Ile Asp Leu Arg Thr Ser Thr Ser 
            180                 185                 190         


Gln Ala Val Phe Arg Leu Gln Ser Gly Ile Val His Leu Phe Arg Glu 
        195                 200                 205             


Thr Leu Ile Asn Lys Gly Phe Val Glu Ile Gln Thr Pro Lys Ile Ile 
    210                 215                 220                 


Ser Ala Ala Ser Glu Gly Gly Ala Asn Val Phe Thr Val Ser Tyr Phe 
225                 230                 235                 240 


Lys Asn Asn Ala Tyr Leu Ala Gln Ser Pro Gln Leu Tyr Lys Gln Met 
                245                 250                 255     


Cys Ile Ala Ala Asp Phe Glu Lys Val Phe Ser Ile Gly Pro Val Phe 
            260                 265                 270         


Arg Ala Glu Asp Ser Asn Thr His Arg His Leu Thr Glu Phe Val Gly 
        275                 280                 285             


Leu Asp Ile Glu Met Ala Phe Asn Tyr His Tyr His Glu Val Met Glu 
    290                 295                 300                 


Glu Ile Ala Asp Thr Met Val Gln Ile Phe Lys Gly Leu Gln Glu Arg 
305                 310                 315                 320 


Phe Gln Thr Glu Ile Gln Thr Val Asn Lys Gln Phe Pro Ser Glu Pro 
                325                 330                 335     


Phe Lys Phe Leu Glu Pro Thr Leu Arg Leu Glu Tyr Ser Glu Ala Leu 
            340                 345                 350         


Ala Met Leu Arg Glu Ala Gly Val Glu Met Gly Asp Glu Asp Asp Leu 
        355                 360                 365             


Ser Thr Pro Asn Glu Lys Leu Leu Gly His Leu Val Lys Glu Lys Tyr 
    370                 375                 380                 


Asp Thr Asp Phe Tyr Ile Leu Asp Lys Tyr Pro Leu Ala Val Arg Pro 
385                 390                 395                 400 


Phe Tyr Thr Met Pro Asp Pro Arg Asn Pro Lys Gln Ser Asn Ser Tyr 
                405                 410                 415     


Asp Met Phe Met Arg Gly Glu Glu Ile Leu Ser Gly Ala Gln Arg Ile 
            420                 425                 430         


His Asp Pro Gln Leu Leu Thr Glu Arg Ala Leu His His Gly Ile Asp 
        435                 440                 445             


Leu Glu Lys Ile Lys Ala Tyr Ile Asp Ser Phe Arg Phe Gly Ala Pro 
    450                 455                 460                 


Pro His Ala Gly Gly Gly Ile Gly Leu Glu Arg Val Thr Met Leu Phe 
465                 470                 475                 480 


Leu Gly Leu His Asn Val Arg Gln Thr Ser Met Phe Pro Arg Asp Pro 
                485                 490                 495     


Lys Arg Leu Thr Pro 
            500     


<210>  118
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  118
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat ctgagccatt caaatttttg     1020

gagccaactc taagactaga atattgtgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  119
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  119
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat gtgagccatt caaatttttg     1020

gagccaactc taagactaga atattctgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  120
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  120
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatctgcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat ctgagccatt caaatttttg     1020

gagccaactc taagactaga atattctgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  121
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  121
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatcgccc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat gtgagccatt caaatttttg     1020

gagccaactc taagactaga atattgtgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  122
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  122
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatcgtcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat gtgagccatt caaatttttg     1020

gagccaactc taagactaga atattgtgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  123
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  123
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatcgccc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat ctgagccatt caaatttttg     1020

gagccaactc taagactaga atattctgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  124
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  124
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatcgtcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg catttgtgct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat ctgagccatt caaatttttg     1020

gagccaactc taagactaga atattctgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  125
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  125
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatcgccc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg cattgcggct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat ctgagccatt caaatttttg     1020

gagccaactc taagactaga atattctgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  126
<211>  1503
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DRS polynucleotide encoding polypetide variant with reduced 
       cysteine content

<400>  126
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaacagag tcattgatct taggacatca actagtcagg cagtcttccg tctccagtct      600

ggcatcgtcc atctcttccg agaaacttta attaacaaag gttttgtgga aatccaaact      660

cctaaaatta tttcagctgc cagtgaagga ggagccaatg tttttactgt gtcatatttt      720

aaaaataatg catacctggc tcagtcccca cagctatata agcaaatgtg cattgcggct      780

gattttgaga aggttttctc tattggacca gtattcagag cggaagactc taatacccat      840

agacatctaa ctgagtttgt tggtttggac attgaaatgg cttttaatta ccattaccac      900

gaagttatgg aagaaattgc tgacaccatg gtacaaatat tcaaaggact tcaagaaagg      960

tttcagactg aaattcaaac agtgaataaa cagttcccat ctgagccatt caaatttttg     1020

gagccaactc taagactaga atattctgaa gcattggcta tgcttaggga agctggagtc     1080

gaaatgggag atgaagacga tctgagcaca ccaaatgaaa agctgttggg tcatttggta     1140

aaggaaaagt atgatacaga tttttatatt cttgataaat atccattggc tgtaagacct     1200

ttctatacca tgcctgaccc aagaaatccc aaacagtcca actcttacga tatgttcatg     1260

agaggagaag aaatattgtc aggagctcaa agaatacatg atcctcaact gctaacagag     1320

agagctttac atcatggaat tgatttggag aaaattaagg cttacattga ttccttccgc     1380

tttggagccc ctcctcatgc tggtggaggc attggattgg aacgagttac tatgctgttt     1440

ctgggattgc ataatgttcg tcagacctcc atgttccctc gtgatcccaa acgactcact     1500

cct                                                                   1503


<210>  127
<211>  546
<212>  DNA
<213>  Homo sapiens

<400>  127
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540

gacaac                                                                 546


<210>  128
<211>  540
<212>  DNA
<213>  Homo sapiens

<400>  128
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga tacaagatta      540


<210>  129
<211>  534
<212>  DNA
<213>  Homo sapiens

<400>  129
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccagga taca            534


<210>  130
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  130
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg ttaaccag                   528


<210>  131
<211>  522
<212>  DNA
<213>  Homo sapiens

<400>  131
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagctactg tt                         522


<210>  132
<211>  516
<212>  DNA
<213>  Homo sapiens

<400>  132
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga agagct                                516


<210>  133
<211>  510
<212>  DNA
<213>  Homo sapiens

<400>  133
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agaggaagga                                       510


<210>  134
<211>  504
<212>  DNA
<213>  Homo sapiens

<400>  134
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaaggaga agag                                             504


<210>  135
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  135
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg cagaagga                                                    498


<210>  136
<211>  492
<212>  DNA
<213>  Homo sapiens

<400>  136
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcctgagg ca                                                          492


<210>  137
<211>  486
<212>  DNA
<213>  Homo sapiens

<400>  137
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480

cggcct                                                                 486


<210>  138
<211>  480
<212>  DNA
<213>  Homo sapiens

<400>  138
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgatgctgtt      480


<210>  139
<211>  474
<212>  DNA
<213>  Homo sapiens

<400>  139
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctgga tgat            474


<210>  140
<211>  468
<212>  DNA
<213>  Homo sapiens

<400>  140
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tgcagctg                   468


<210>  141
<211>  462
<212>  DNA
<213>  Homo sapiens

<400>  141
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctgcccc tg                         462


<210>  142
<211>  456
<212>  DNA
<213>  Homo sapiens

<400>  142
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc cgtctg                                456


<210>  143
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  143
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggctgaaccc                                       450


<210>  144
<211>  444
<212>  DNA
<213>  Homo sapiens

<400>  144
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagttt ggct                                             444


<210>  145
<211>  438
<212>  DNA
<213>  Homo sapiens

<400>  145
atgcccagcg ccagcgccag ccgcaagagt caggagaagc cgcgggagat catggacgcg       60

gcggaagatt atgctaaaga gagatatgga atatcttcaa tgatacaatc acaagaaaaa      120

ccagatcgag ttttggttcg ggttagagac ttgacaatac aaaaagctga tgaagttgtt      180

tgggtacgtg caagagttca tacaagcaga gctaaaggga aacagtgctt cttagtccta      240

cgtcagcagc agtttaatgt ccaggctctt gtggcggtgg gagaccatgc aagcaagcag      300

atggttaaat ttgctgccaa catcaacaaa gagagcattg tggatgtaga aggtgttgtg      360

agaaaagtga atcagaaaat tggaagctgt acacagcaag acgttgagtt acatgttcag      420

aagatttatg tgatcagt                                                    438


<210>  146
<211>  453
<212>  DNA
<213>  Homo sapiens

<400>  146
gccagcgcca gccgcaagag tcaggagaag ccgcgggaga tcatggacgc ggcggaagat       60

tatgctaaag agagatatgg aatatcttca atgatacaat cacaagaaaa accagatcga      120

gttttggttc gggttagaga cttgacaata caaaaagctg atgaagttgt ttgggtacgt      180

gcaagagttc atacaagcag agctaaaggg aaacagtgct tcttagtcct acgtcagcag      240

cagtttaatg tccaggctct tgtggcggtg ggagaccatg caagcaagca gatggttaaa      300

tttgctgcca acatcaacaa agagagcatt gtggatgtag aaggtgttgt gagaaaagtg      360

aatcagaaaa ttggaagctg tacacagcaa gacgttgagt tacatgttca gaagatttat      420

gtgatcagtt tggctgaacc ccgtctgccc ctg                                   453


<210>  147
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  147
gccagccgca agagtcagga gaagccgcgg gagatcatgg acgcggcgga agattatgct       60

aaagagagat atggaatatc ttcaatgata caatcacaag aaaaaccaga tcgagttttg      120

gttcgggtta gagacttgac aatacaaaaa gctgatgaag ttgtttgggt acgtgcaaga      180

gttcatacaa gcagagctaa agggaaacag tgcttcttag tcctacgtca gcagcagttt      240

aatgtccagg ctcttgtggc ggtgggagac catgcaagca agcagatggt taaatttgct      300

gccaacatca acaaagagag cattgtggat gtagaaggtg ttgtgagaaa agtgaatcag      360

aaaattggaa gctgtacaca gcaagacgtt gagttacatg ttcagaagat ttatgtgatc      420

agtttggctg aaccccgtct gcccctg                                          447


<210>  148
<211>  441
<212>  DNA
<213>  Homo sapiens

<400>  148
cgcaagagtc aggagaagcc gcgggagatc atggacgcgg cggaagatta tgctaaagag       60

agatatggaa tatcttcaat gatacaatca caagaaaaac cagatcgagt tttggttcgg      120

gttagagact tgacaataca aaaagctgat gaagttgttt gggtacgtgc aagagttcat      180

acaagcagag ctaaagggaa acagtgcttc ttagtcctac gtcagcagca gtttaatgtc      240

caggctcttg tggcggtggg agaccatgca agcaagcaga tggttaaatt tgctgccaac      300

atcaacaaag agagcattgt ggatgtagaa ggtgttgtga gaaaagtgaa tcagaaaatt      360

ggaagctgta cacagcaaga cgttgagtta catgttcaga agatttatgt gatcagtttg      420

gctgaacccc gtctgcccct g                                                441


<210>  149
<211>  435
<212>  DNA
<213>  Homo sapiens

<400>  149
agtcaggaga agccgcggga gatcatggac gcggcggaag attatgctaa agagagatat       60

ggaatatctt caatgataca atcacaagaa aaaccagatc gagttttggt tcgggttaga      120

gacttgacaa tacaaaaagc tgatgaagtt gtttgggtac gtgcaagagt tcatacaagc      180

agagctaaag ggaaacagtg cttcttagtc ctacgtcagc agcagtttaa tgtccaggct      240

cttgtggcgg tgggagacca tgcaagcaag cagatggtta aatttgctgc caacatcaac      300

aaagagagca ttgtggatgt agaaggtgtt gtgagaaaag tgaatcagaa aattggaagc      360

tgtacacagc aagacgttga gttacatgtt cagaagattt atgtgatcag tttggctgaa      420

ccccgtctgc ccctg                                                       435


<210>  150
<211>  429
<212>  DNA
<213>  Homo sapiens

<400>  150
gagaagccgc gggagatcat ggacgcggcg gaagattatg ctaaagagag atatggaata       60

tcttcaatga tacaatcaca agaaaaacca gatcgagttt tggttcgggt tagagacttg      120

acaatacaaa aagctgatga agttgtttgg gtacgtgcaa gagttcatac aagcagagct      180

aaagggaaac agtgcttctt agtcctacgt cagcagcagt ttaatgtcca ggctcttgtg      240

gcggtgggag accatgcaag caagcagatg gttaaatttg ctgccaacat caacaaagag      300

agcattgtgg atgtagaagg tgttgtgaga aaagtgaatc agaaaattgg aagctgtaca      360

cagcaagacg ttgagttaca tgttcagaag atttatgtga tcagtttggc tgaaccccgt      420

ctgcccctg                                                              429


<210>  151
<211>  423
<212>  DNA
<213>  Homo sapiens

<400>  151
ccgcgggaga tcatggacgc ggcggaagat tatgctaaag agagatatgg aatatcttca       60

atgatacaat cacaagaaaa accagatcga gttttggttc gggttagaga cttgacaata      120

caaaaagctg atgaagttgt ttgggtacgt gcaagagttc atacaagcag agctaaaggg      180

aaacagtgct tcttagtcct acgtcagcag cagtttaatg tccaggctct tgtggcggtg      240

ggagaccatg caagcaagca gatggttaaa tttgctgcca acatcaacaa agagagcatt      300

gtggatgtag aaggtgttgt gagaaaagtg aatcagaaaa ttggaagctg tacacagcaa      360

gacgttgagt tacatgttca gaagatttat gtgatcagtt tggctgaacc ccgtctgccc      420

ctg                                                                    423


<210>  152
<211>  417
<212>  DNA
<213>  Homo sapiens

<400>  152
gagatcatgg acgcggcgga agattatgct aaagagagat atggaatatc ttcaatgata       60

caatcacaag aaaaaccaga tcgagttttg gttcgggtta gagacttgac aatacaaaaa      120

gctgatgaag ttgtttgggt acgtgcaaga gttcatacaa gcagagctaa agggaaacag      180

tgcttcttag tcctacgtca gcagcagttt aatgtccagg ctcttgtggc ggtgggagac      240

catgcaagca agcagatggt taaatttgct gccaacatca acaaagagag cattgtggat      300

gtagaaggtg ttgtgagaaa agtgaatcag aaaattggaa gctgtacaca gcaagacgtt      360

gagttacatg ttcagaagat ttatgtgatc agtttggctg aaccccgtct gcccctg         417


<210>  153
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  153
atggacgcgg cggaagatta tgctaaagag agatatggaa tatcttcaat gatacaatca       60

caagaaaaac cagatcgagt tttggttcgg gttagagact tgacaataca aaaagctgat      120

gaagttgttt gggtacgtgc aagagttcat acaagcagag ctaaagggaa acagtgcttc      180

ttagtcctac gtcagcagca gtttaatgtc caggctcttg tggcggtggg agaccatgca      240

agcaagcaga tggttaaatt tgctgccaac atcaacaaag agagcattgt ggatgtagaa      300

ggtgttgtga gaaaagtgaa tcagaaaatt ggaagctgta cacagcaaga cgttgagtta      360

catgttcaga agatttatgt gatcagtttg gctgaacccc gtctgcccct g               411


<210>  154
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  154
gcggcggaag attatgctaa agagagatat ggaatatctt caatgataca atcacaagaa       60

aaaccagatc gagttttggt tcgggttaga gacttgacaa tacaaaaagc tgatgaagtt      120

gtttgggtac gtgcaagagt tcatacaagc agagctaaag ggaaacagtg cttcttagtc      180

ctacgtcagc agcagtttaa tgtccaggct cttgtggcgg tgggagacca tgcaagcaag      240

cagatggtta aatttgctgc caacatcaac aaagagagca ttgtggatgt agaaggtgtt      300

gtgagaaaag tgaatcagaa aattggaagc tgtacacagc aagacgttga gttacatgtt      360

cagaagattt atgtgatcag tttggctgaa ccccgtctgc ccctg                      405


<210>  155
<211>  399
<212>  DNA
<213>  Homo sapiens

<400>  155
gcggcggaag attatgctaa agagagatat ggaatatctt caatgataca atcacaagaa       60

aaaccagatc gagttttggt tcgggttaga gacttgacaa tacaaaaagc tgatgaagtt      120

gtttgggtac gtgcaagagt tcatacaagc agagctaaag ggaaacagtg cttcttagtc      180

ctacgtcagc agcagtttaa tgtccaggct cttgtggcgg tgggagacca tgcaagcaag      240

cagatggtta aatttgctgc caacatcaac aaagagagca ttgtggatgt agaaggtgtt      300

gtgagaaaag tgaatcagaa aattggaagc tgtacacagc aagacgttga gttacatgtt      360

cagaagattt atgtgatcag tttggctgaa ccccgtctg                             399


<210>  156
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  156
gcggcggaag attatgctaa agagagatat ggaatatctt caatgataca atcacaagaa       60

aaaccagatc gagttttggt tcgggttaga gacttgacaa tacaaaaagc tgatgaagtt      120

gtttgggtac gtgcaagagt tcatacaagc agagctaaag ggaaacagtg cttcttagtc      180

ctacgtcagc agcagtttaa tgtccaggct cttgtggcgg tgggagacca tgcaagcaag      240

cagatggtta aatttgctgc caacatcaac aaagagagca ttgtggatgt agaaggtgtt      300

gtgagaaaag tgaatcagaa aattggaagc tgtacacagc aagacgttga gttacatgtt      360

cagaagattt atgtgatcag tttggctgaa ccc                                   393


<210>  157
<211>  411
<212>  DNA
<213>  Homo sapiens

<400>  157
atgcaggaga agccgcggga gatcatggac gcggcggaag attatgctaa agagagatat       60

ggaatatctt caatgataca atcacaagaa aaaccagatc gagttttggt tcgggttaga      120

gacttgacaa tacaaaaagc tgatgaagtt gtttgggtac gtgcaagagt tcatacaagc      180

agagctaaag ggaaacagtg cttcttagtc ctacgtcagc agcagtttaa tgtccaggct      240

cttgtggcgg tgggagacca tgcaagcaag cagatggtta aatttgcttg caacatcaac      300

aaagagagca ttgtggatgt agaaggtgtt gtgagaaaag tgaatcagaa aattggaagc      360

tgtacacagc aagacgttga gttacatgtt cagaagattt atgtgatcag t               411


<210>  158
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  158
atgaagccgc gggagatcat ggacgcggcg gaagattatg ctaaagagag atatggaata       60

tcttcaatga tacaatcaca agaaaaacca gatcgagttt tggttcgggt tagagacttg      120

acaatacaaa aagctgatga agttgtttgg gtacgtgcaa gagttcatac aagcagagct      180

aaagggaaac agtgcttctt agtcctacgt cagcagcagt ttaatgtcca ggctcttgtg      240

gcggtgggag accatgcaag caagcagatg gttaaatttg cttgcaacat caacaaagag      300

agcattgtgg atgtagaagg tgttgtgaga aaagtgaatc agaaaattgg aagctgtaca      360

cagcaagacg ttgagttaca tgttcagaag atttatgtga tcagt                      405


<210>  159
<211>  405
<212>  DNA
<213>  Homo sapiens

<400>  159
atgaagccgc gggagatcat ggacgcggcg gaagattatg ctaaagagag atatggaata       60

tcttcaatga tacaatcaca agaaaaacca gatcgagttt tggttcgggt tagagacttg      120

acaatacaaa aagctgatga agttgtttgg gtacgtgcaa gagttcatac aagcagagct      180

aaagggaaac agtgcttctt agtcctacgt cagcagcagt ttaatgtcca ggctcttgtg      240

gcggtgggag accatgcaag caagcagatg gttaaatttg cttgcaacat caacaaagag      300

agcattgtgg atgtagaagg tgttgtgaga aaagtgaatc agaaaattgg aagctgtaca      360

cagcaagacg ttgagttaca tgttcagaag atttatgtga tcagt                      405


<210>  160
<211>  393
<212>  DNA
<213>  Homo sapiens

<400>  160
atgatcatgg acgcggcgga agattatgct aaagagagat atggaatatc ttcaatgata       60

caatcacaag aaaaaccaga tcgagttttg gttcgggtta gagacttgac aatacaaaaa      120

gctgatgaag ttgtttgggt acgtgcaaga gttcatacaa gcagagctaa agggaaacag      180

tgcttcttag tcctacgtca gcagcagttt aatgtccagg ctcttgtggc ggtgggagac      240

catgcaagca agcagatggt taaatttgct tgcaacatca acaaagagag cattgtggat      300

gtagaaggtg ttgtgagaaa agtgaatcag aaaattggaa gctgtacaca gcaagacgtt      360

gagttacatg ttcagaagat ttatgtgatc agt                                   393


<210>  161
<211>  381
<212>  DNA
<213>  Homo sapiens

<400>  161
atggcggaag attatgctaa agagagatat ggaatatctt caatgataca atcacaagaa       60

aaaccagatc gagttttggt tcgggttaga gacttgacaa tacaaaaagc tgatgaagtt      120

gtttgggtac gtgcaagagt tcatacaagc agagctaaag ggaaacagtg cttcttagtc      180

ctacgtcagc agcagtttaa tgtccaggct cttgtggcgg tgggagacca tgcaagcaag      240

cagatggtta aatttgcttg caacatcaac aaagagagca ttgtggatgt agaaggtgtt      300

gtgagaaaag tgaatcagaa aattggaagc tgtacacagc aagacgttga gttacatgtt      360

cagaagattt atgtgatcag t                                                381


<210>  162
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  162
cagttcccat ctgagccatt c                                                 21


<210>  163
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  163
gactagaata ttctgaagca ttggc                                             25


<210>  164
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  164
ccagtctggc atcgcccatc tcttcc                                            26


<210>  165
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  165
ccagtctggc atcgtccatc tcttcc                                            26


<210>  166
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  166
ccacagctat ataagcaaat gtgcattgcg gctgattttg ag                          42


<210>  167
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  167
gggttaggga taggcttacc agccaaactg atcacataaa tc                          42


<210>  168
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  168
gggttaggga taggcttacc gggttcagcc aaactgatca c                           41


<210>  169
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  169
gggttaggga taggcttacc cagacggggt tcagccaaac                             40


<210>  170
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  170
gggttaggga taggcttacc cagctgcagg ggcagacggg g                           41


<210>  171
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  171
gggttaggga taggcttacc atcatccagc tgcaggggca g                           41


<210>  172
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  172
gggttaggga taggcttacc aacagcatca tccagctgca gg                          42


<210>  173
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  173
gggttaggga taggcttacc aggccgaaca gcatcatcca g                           41


<210>  174
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  174
gggttaggga taggcttacc tgcctcaggc cgaacagcat c                           41


<210>  175
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  175
gggttaggga taggcttacc tccttctgcc tcaggccgaa c                           41


<210>  176
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  176
gggttaggga taggcttacc ctcttctcct tctgcctcag g                           41


<210>  177
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  177
gggttaggga taggcttacc tccttcctct tctccttctg c                           41


<210>  178
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  178
gggttaggga taggcttacc agctcttcct tcctcttctc c                           41


<210>  179
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  179
gggttaggga taggcttacc ctggttaaca gtagctcttc c                           41


<210>  180
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  180
gggttaggga taggcttacc tgtatcctgg ttaacagtag c                           41


<210>  181
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  181
gggttaggga taggcttacc taatcttgta tcctggttaa c                           41


<210>  182
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  182
gggttaggga taggcttacc gttgtctaat cttgtatcct gg                          42


<210>  183
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  183
gaaggagata taccatgagc gccagcgcca gccg                                   34


<210>  184
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  184
gaaggagata taccatgagc gccagccgca agag                                   34


<210>  185
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  185
gaaggagata taccatgagc cgcaagagtc aggag                                  35


<210>  186
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  186
gaaggagata taccatgaag agtcaggaga agcc                                   34


<210>  187
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  187
gaaggagata tcatatgcag gagaagccgc gggag                                  35


<210>  188
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  188
gaaggagata tcatatgaag ccgcgggaga tcatg                                  35


<210>  189
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  189
gaaggagata tcatatgcgg gagatcatgg acgcgg                                 36


<210>  190
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  190
gaaggagata tcatatgatc atggacgcgg cgg                                    33


<210>  191
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  191
gaaggagata tcatatggcg gaagattatg ctaaag                                 36


<210>  192
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  192
gaaggagata tcatatggat tatgctaaag                                        30


<210>  193
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  193
accgatcaca tatgcaggag aagccgcggg agatcatgga                             40


<210>  194
<211>  39
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  194
aagcttacgc atatgaagcc gcgggagatc atggacgcg                              39


<210>  195
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  195
aactgttacc atatgatcat ggacgcggcg gaagattatg                             40


<210>  196
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  196
aactgtcatc atatggcgga agattatgct aaagagagat at                          42


<210>  197
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  197
tgacggctcg agactgatca cataaatctt ctg                                    33


<210>  198
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  198
gcagatggtt aaatttgctt gcaacatcaa caaagagagc attgtgg                     47


