                         SEQUENCE LISTING

<110>  Biotest AG
       ImmunoGen, Inc.
 
<120>  USES OF IMMUNOCONJUGATES TARGETING CD138

<130>  332630WO/CJS

<140>  
<141>  

<150>  61/722,367
<151>  2012-11-05

<150>  61/568,640
<151>  2011-12-08

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  448
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence (predicted) of heavy chain of chimeric 
       human/mouse antibody


<220>
<221>  CDR1
<222>  (31)..(35)

<220>
<221>  CDR2
<222>  (51)..(68)

<220>
<221>  CDR3
<222>  (99)..(111)

<400>  1

Gln Val Gln Leu Gln Gln Ser Gly Ser Glu Leu Met Met Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Thr Gly Arg Thr Ile Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Phe Thr Ala Asp Ile Ser Ser Asn Thr Val Gln 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Asp Tyr Tyr Gly Asn Phe Tyr Tyr Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 
    210                 215                 220                 


Gly Pro Pro Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 
            260                 265                 270         


Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 
        435                 440                 445             


<210>  2
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Amino Acid sequence (predicted) of light chain of chimeric 
       human/mouse antibody


<220>
<221>  CDR1
<222>  (24)..(34)

<220>
<221>  CDR2
<222>  (50)..(56)

<220>
<221>  CDR3
<222>  (89)..(97)

<400>  2

Asp Ile Gln Met Thr Gln Ser Thr Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Ser Ala Ser Gln Gly Ile Asn Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val Glu Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser Asn Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Ile Gly Thr Tyr Tyr Cys Gln Gln Tyr Ser Lys Leu Pro Arg 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  3
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgH primer MHV7

<400>  3
atgggcatca agatggagtc acagacccag g                                      31


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1 constant region primer MHCG1

<400>  4
cagtggatag acagatgggg g                                                 21


<210>  5
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ig kappa primer MKV2

<400>  5
atggagacag acacactcct gctatgggtg                                        30


<210>  6
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ig kappa primer MKV4

<400>  6
atgagggccc ctgctcagtt ttttggcttc ttg                                    33


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Ig kappa primer MKV9

<400>  7
atggtatcca cacctcagtt ccttg                                             25


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer MKC

<400>  8
actggatggt gggaagatgg                                                   20


<210>  9
<211>  50
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward (For) primer

<400>  9
agagaagctt gccgccacca tgattgcctc tgctcagttc cttggtctcc                  50


<210>  10
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer BT03

<400>  10
caacagtata gtaagctccc tcggacgttc ggtgg                                  35


<210>  11
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  oligonucleotide primer BT04

<400>  11
ccaccgaacg tccgagggag cttactatac tgttg                                  35


<210>  12
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  primer g2258

<400>  12
cgcgggatcc actcacgttt gatttccagc ttggtgcctc c                           41


<210>  13
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer g22949

<400>  13
cgatgggccc ttggtggagg ctgaggagac ggtgactgag gttcc                       45


