
                                SEQUENCE LISTING

<110> ProtevoBio, Inc.
      Innovent Biologics, Inc.
      HER, Jeng-Horng
      CHEN, Huang-Tsu

<120> PROTEIN INHIBITORS TO COMPLEMENT AND
  VEGF PATHWAYS AND METHODS OF USE THEREOF
  

<130> 701672000140

<140> PCT/US2012/067489   
<141> 2012-11-30  

<150> US 61/629,932       
<151> 2011-12-01  

<160> 43

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 193
<212> PRT
<213> Homo sapiens

<400> 1
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile
    


<210> 2
<211> 193
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 2
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Lys Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile
    


<210> 3
<211> 193
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 3
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Asp
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile
    


<210> 4
<211> 193
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 4
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Lys Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Asp
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile
    


<210> 5
<211> 193
<212> PRT
<213> Homo sapiens

<400> 5
Pro His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr
 1               5                  10                  15      
Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu
            20                  25                  30          
Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp
        35                  40                  45              
Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys Ser Cys
    50                  55                  60                  
Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Thr Asp
65                  70                  75                  80  
Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly His Arg
                85                  90                  95      
Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala
            100                 105                 110         
His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile
    


<210> 6
<211> 643
<212> PRT
<213> Homo sapiens

<400> 6
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Asn Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Ser Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Gly
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asp Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile Ile Pro Asn Lys Cys Thr Pro Pro Asn Val Glu Asn Gly Ile Leu
        195                 200                 205             
Val Ser Asp Asn Arg Ser Leu Phe Ser Leu Asn Glu Val Val Glu Phe
    210                 215                 220                 
Arg Cys Gln Pro Gly Phe Val Met Lys Gly Pro Arg Arg Val Lys Cys
225                 230                 235                 240 
Gln Ala Leu Asn Lys Trp Glu Pro Glu Leu Pro Ser Cys Ser Arg Val
                245                 250                 255     
Cys Gln Pro Pro Pro Asp Val Leu His Ala Glu Arg Thr Gln Arg Asp
            260                 265                 270         
Lys Asp Asn Phe Ser Pro Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro
        275                 280                 285             
Gly Tyr Asp Leu Arg Gly Ala Ala Ser Met Arg Cys Thr Pro Gln Gly
    290                 295                 300                 
Asp Trp Ser Pro Ala Ala Pro Thr Cys Glu Val Lys Ser Cys Asp Asp
305                 310                 315                 320 
Phe Met Gly Gln Leu Leu Asn Gly Arg Val Leu Phe Pro Val Asn Leu
                325                 330                 335     
Gln Leu Gly Ala Lys Val Asp Phe Val Cys Asp Glu Gly Phe Gln Leu
            340                 345                 350         
Lys Gly Ser Ser Ala Ser Tyr Cys Val Leu Ala Gly Met Glu Ser Leu
        355                 360                 365             
Trp Asn Ser Ser Val Pro Val Cys Glu Gln Ile Phe Cys Pro Ser Pro
    370                 375                 380                 
Pro Val Ile Pro Asn Gly Arg His Thr Gly Lys Pro Leu Glu Val Phe
385                 390                 395                 400 
Pro Phe Gly Lys Thr Val Asn Tyr Thr Cys Asp Pro His Pro Asp Arg
                405                 410                 415     
Gly Thr Ser Phe Asp Leu Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser
            420                 425                 430         
Asp Pro Gln Gly Asn Gly Val Trp Ser Ser Pro Ala Pro Arg Cys Gly
        435                 440                 445             
Ile Leu Gly His Cys Gln Ala Pro Asp His Phe Leu Phe Ala Lys Leu
    450                 455                 460                 
Lys Thr Gln Thr Asn Ala Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys
465                 470                 475                 480 
Tyr Glu Cys Arg Pro Glu Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys
                485                 490                 495     
Leu Asp Asn Leu Val Trp Ser Ser Pro Lys Asp Val Cys Lys Arg Lys
            500                 505                 510         
Ser Cys Lys Thr Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile
        515                 520                 525             
Thr Asp Ile Gln Val Gly Ser Arg Ile Asn Tyr Ser Cys Thr Thr Gly
    530                 535                 540                 
His Arg Leu Ile Gly His Ser Ser Ala Glu Cys Ile Leu Ser Gly Asn
545                 550                 555                 560 
Ala Ala His Trp Ser Thr Lys Pro Pro Ile Cys Gln Arg Ile Pro Cys
                565                 570                 575     
Gly Leu Pro Pro Thr Ile Ala Asn Gly Asp Phe Ile Ser Thr Asn Arg
            580                 585                 590         
Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly
        595                 600                 605             
Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr
    610                 615                 620                 
Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro
625                 630                 635                 640 
Gln Cys Ile
            


<210> 7
<211> 228
<212> PRT
<213> Homo sapiens

<400> 7
Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
 1               5                  10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Lys
225             


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 8
Pro Gly Gly Gly Gly Gly Gly
 1               5          


<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 9
Pro Met Ala Trp Met Met Leu Leu Leu Gly Leu Leu Ala Tyr Gly Ser
 1               5                  10                  15      
Gly Val Asp Ser
            20  


<210> 10
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 10
Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val
 1               5                  10                  15      
Pro Gly Ser Thr Gly Asp Thr
            20              


<210> 11
<211> 203
<212> PRT
<213> Homo sapiens

<400> 11
Pro Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile
 1               5                  10                  15      
His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser
            20                  25                  30          
Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile
        35                  40                  45              
Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile
    50                  55                  60                  
Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr
65                  70                  75                  80  
Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr
                85                  90                  95      
Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu
            100                 105                 110         
Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu
        115                 120                 125             
Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln
    130                 135                 140                 
His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu
145                 150                 155                 160 
Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser
                165                 170                 175     
Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys
            180                 185                 190         
Lys Asn Ser Thr Phe Val Arg Val His Glu Lys
        195                 200             


<210> 12
<211> 628
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 12
Pro Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile
 1               5                  10                  15      
His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser
            20                  25                  30          
Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile
        35                  40                  45              
Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile
    50                  55                  60                  
Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr
65                  70                  75                  80  
Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr
                85                  90                  95      
Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu
            100                 105                 110         
Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu
        115                 120                 125             
Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln
    130                 135                 140                 
His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu
145                 150                 155                 160 
Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser
                165                 170                 175     
Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys
            180                 185                 190         
Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr His Thr
        195                 200                 205             
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
    210                 215                 220                 
Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro
225                 230                 235                 240 
Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val
                245                 250                 255     
Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
            260                 265                 270         
Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
        275                 280                 285             
Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys
    290                 295                 300                 
Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser
305                 310                 315                 320 
Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro
                325                 330                 335     
Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val
            340                 345                 350         
Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly
        355                 360                 365             
Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp
    370                 375                 380                 
Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp
385                 390                 395                 400 
Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His
                405                 410                 415     
Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly
            420                 425                 430         
Gly Gly Gly Gly Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg
        435                 440                 445             
Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu
    450                 455                 460                 
Lys Tyr Glu Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser Ile Ile
465                 470                 475                 480 
Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg
                485                 490                 495     
Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val
            500                 505                 510         
Ile Lys Asp Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys
        515                 520                 525             
Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly
    530                 535                 540                 
Asn Thr Val Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro
545                 550                 555                 560 
Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn
                565                 570                 575     
Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro
            580                 585                 590         
Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile
        595                 600                 605             
Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala
    610                 615                 620                 
Pro Gln Cys Ile
625             


<210> 13
<211> 190
<212> PRT
<213> Homo sapiens

<400> 13
Pro Arg Ser Cys Glu Val Pro Thr Arg Leu Asn Ser Ala Ser Leu Lys
 1               5                  10                  15      
Gln Pro Tyr Ile Thr Gln Asn Tyr Phe Pro Val Gly Thr Val Val Glu
            20                  25                  30          
Tyr Glu Cys Arg Pro Gly Tyr Arg Arg Glu Pro Ser Leu Ser Pro Lys
        35                  40                  45              
Leu Thr Cys Leu Gln Asn Leu Lys Trp Ser Thr Ala Val Glu Phe Cys
    50                  55                  60                  
Lys Lys Lys Ser Cys Pro Asn Pro Gly Glu Ile Arg Asn Gly Gln Ile
65                  70                  75                  80  
Asp Val Pro Gly Gly Ile Leu Phe Gly Ala Thr Ile Ser Phe Ser Cys
                85                  90                  95      
Asn Thr Gly Tyr Lys Leu Phe Gly Ser Thr Ser Ser Phe Cys Leu Ile
            100                 105                 110         
Ser Gly Ser Ser Val Gln Trp Ser Asp Pro Leu Pro Glu Cys Arg Glu
        115                 120                 125             
Ile Tyr Cys Pro Ala Pro Pro Gln Ile Asp Asn Gly Ile Ile Gln Gly
    130                 135                 140                 
Glu Arg Asp His Tyr Gly Tyr Arg Gln Ser Val Thr Tyr Ala Cys Asn
145                 150                 155                 160 
Lys Gly Phe Thr Met Ile Gly Glu His Ser Ile Tyr Cys Thr Val Asn
                165                 170                 175     
Asn Asp Glu Gly Glu Trp Ser Gly Pro Pro Pro Glu Cys Arg
            180                 185                 190 


<210> 14
<211> 190
<212> PRT
<213> Homo sapiens

<400> 14
Pro Arg Glu Thr Cys Pro Tyr Ile Arg Asp Pro Leu Asn Gly Gln Ala
 1               5                  10                  15      
Val Pro Ala Asn Gly Thr Tyr Glu Phe Gly Tyr Gln Met His Phe Ile
            20                  25                  30          
Cys Asn Glu Gly Tyr Tyr Leu Ile Gly Glu Glu Ile Leu Tyr Cys Glu
        35                  40                  45              
Leu Lys Gly Ser Val Ala Ile Trp Ser Gly Lys Pro Pro Ile Cys Glu
    50                  55                  60                  
Lys Val Leu Cys Thr Pro Pro Pro Lys Ile Lys Asn Gly Lys His Thr
65                  70                  75                  80  
Phe Ser Glu Val Glu Val Phe Glu Tyr Leu Asp Ala Val Thr Tyr Ser
                85                  90                  95      
Cys Asp Pro Ala Pro Gly Pro Asp Pro Phe Ser Leu Ile Gly Glu Ser
            100                 105                 110         
Thr Ile Tyr Cys Gly Asp Asn Ser Val Trp Ser Arg Ala Ala Pro Glu
        115                 120                 125             
Cys Lys Val Val Lys Cys Arg Phe Pro Val Val Glu Asn Gly Lys Gln
    130                 135                 140                 
Ile Ser Gly Phe Gly Lys Lys Phe Tyr Tyr Lys Ala Thr Val Met Phe
145                 150                 155                 160 
Glu Cys Asp Lys Gly Phe Tyr Leu Asp Gly Ser Asp Thr Ile Val Cys
                165                 170                 175     
Asp Ser Asn Ser Thr Trp Asp Pro Pro Val Pro Lys Cys Leu
            180                 185                 190 


<210> 15
<211> 246
<212> PRT
<213> Homo sapiens

<400> 15
Pro Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile Leu
 1               5                  10                  15      
Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala Ile
            20                  25                  30          
Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met Val
        35                  40                  45              
Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys Gln
    50                  55                  60                  
Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe Thr
65                  70                  75                  80  
Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr Thr
                85                  90                  95      
Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu Cys
            100                 105                 110         
Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val Lys
        115                 120                 125             
Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser Ala
    130                 135                 140                 
Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe Val
145                 150                 155                 160 
Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys Ser
                165                 170                 175     
Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile Ser
            180                 185                 190         
Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys Ile
        195                 200                 205             
Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly Tyr
    210                 215                 220                 
Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg
225                 230                 235                 240 
Pro Leu Pro Ser Cys Glu
                245     


<210> 16
<211> 188
<212> PRT
<213> Homo sapiens

<400> 16
Pro Asn Cys Gly Pro Pro Pro Thr Leu Ser Phe Ala Ala Pro Met Asp
 1               5                  10                  15      
Ile Thr Leu Thr Glu Thr Arg Phe Lys Thr Gly Thr Thr Leu Lys Tyr
            20                  25                  30          
Thr Cys Leu Pro Gly Tyr Val Arg Ser His Ser Thr Gln Thr Leu Thr
        35                  40                  45              
Cys Asn Ser Asp Gly Glu Trp Val Tyr Asn Thr Phe Cys Ile Tyr Lys
    50                  55                  60                  
Arg Cys Arg His Pro Gly Glu Leu Arg Asn Gly Gln Val Glu Ile Lys
65                  70                  75                  80  
Thr Asp Leu Ser Phe Gly Ser Gln Ile Glu Phe Ser Cys Ser Glu Gly
                85                  90                  95      
Phe Phe Leu Ile Gly Ser Thr Thr Ser Arg Cys Glu Val Gln Asp Arg
            100                 105                 110         
Gly Val Gly Trp Ser His Pro Leu Pro Gln Cys Glu Ile Val Lys Cys
        115                 120                 125             
Lys Pro Pro Pro Asp Ile Arg Asn Gly Arg His Ser Gly Glu Glu Asn
    130                 135                 140                 
Phe Tyr Ala Tyr Gly Phe Ser Val Thr Tyr Ser Cys Asp Pro Arg Phe
145                 150                 155                 160 
Ser Leu Leu Gly His Ala Ser Ile Ser Cys Thr Val Glu Asn Glu Thr
                165                 170                 175     
Ile Gly Val Trp Arg Pro Ser Pro Pro Thr Cys Glu
            180                 185             


<210> 17
<211> 577
<212> DNA
<213> Homo sapiens

<400> 17
dcaatgcaat gccccagaat ggcttccatt tgccaggcct accaacctaa ctgatgaatt 60
tgagtttccc attgggacat atctgaacta tgaatgccgc cctggttatt ccggaagacc 120
gttttctatc atctgcctaa aaaactcagt ctggactggt gctaaggaca ggtgcagacg 180
taaatcatgt cgtaatcctc cagatcctgt gaatggcatg gtgcatgtga tcaaaggcat 240
ccagttcgga tcccaaatta aatattcttg tactaaagga taccgactca ttggttcctc 300
gtctgccaca tgcatcatct caggtgatac tgtcatttgg gataatgaaa cacctatttg 360
tgacagaatt ccttgtgggc taccccccac catcaccaat ggagatttca ttagcaccaa 420
cagagagaat tttcactatg gatcagtggt gacctaccgc tgcaatcctg gaagcggagg 480
gagaaaggtg tttgagcttg tgggtgagcc ctccatatac tgcaccagca atgacgatca 540
agtgggcatc tggagcggcc ccgcccctca gtgcatt                          577

<210> 18
<211> 577
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 18
dcaatgcaat gccccagaat ggcttccatt tgccaggcct accaacctaa ctgatgaatt 60
tgagtttccc attgggacat atctgaaata tgaatgccgc cctggttatt ccggaagacc 120
gttttctatc atctgcctaa aaaactcagt ctggactggt gctaaggaca ggtgcagacg 180
taaatcatgt cgtaatcctc cagatcctgt gaatggcatg gtgcatgtga tcaaaggcat 240
ccagttcgga tcccaaatta aatattcttg tactaaagga taccgactca ttggttcctc 300
gtctgccaca tgcatcatct caggtaatac tgtcatttgg gataatgaaa cacctatttg 360
tgacagaatt ccttgtgggc taccccccac catcaccaat ggagatttca ttagcaccaa 420
cagagagaat tttcactatg gatcagtggt gacctaccgc tgcaatcctg gaagcggagg 480
gagaaaggtg tttgagcttg tgggtgagcc ctccatatac tgcaccagca atgacgatca 540
agtgggcatc tggagcggcc ccgcccctca gtgcatt                          577

<210> 19
<211> 577
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 19
dcaatgcaat gccccagaat ggcttccatt tgccaggcct accaacctaa ctgatgaatt 60
tgagtttccc attgggacat atctgaacta tgaatgccgc cctggttatt acggaagacc 120
gttttctatc atctgcctaa aaaactcagt ctggactggt gctaaggaca ggtgcagacg 180
taaatcatgt cgtaatcctc cagatcctgt gaatggcatg gtgcatgtga tcaaagacat 240
ccagttcgga tcccaaatta aatattcttg tactaaagga taccgactca ttggttcctc 300
gtctgccaca tgcatcatct caggtgatac tgtcatttgg gataatgaaa cacctatttg 360
tgacagaatt ccttgtgggc taccccccac catcaccaat ggagatttca ttagcaccaa 420
cagagagaat tttcactatg gatcagtggt gacctaccgc tgcaatcctg gaagcggagg 480
gagaaaggtg tttgagcttg tgggtgagcc ctccatatac tgcaccagca atgacgatca 540
agtgggcatc tggagcggcc ccgcccctca gtgcatt                          577

<210> 20
<211> 577
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 20
dcaatgcaat gccccagaat ggcttccatt tgccaggcct accaacctaa ctgatgaatt 60
tgagtttccc attgggacat atctgaaata tgaatgccgc cctggttatt acggaagacc 120
gttttctatc atctgcctaa aaaactcagt ctggactggt gctaaggaca ggtgcagacg 180
taaatcatgt cgtaatcctc cagatcctgt gaatggcatg gtgcatgtga tcaaagacat 240
ccagttcgga tcccaaatta aatattcttg tactaaagga taccgactca ttggttcctc 300
gtctgccaca tgcatcatct caggtaatac tgtcatttgg gataatgaaa cacctatttg 360
tgacagaatt ccttgtgggc taccccccac catcaccaat ggagatttca ttagcaccaa 420
cagagagaat tttcactatg gatcagtggt gacctaccgc tgcaatcctg gaagcggagg 480
gagaaaggtg tttgagcttg tgggtgagcc ctccatatac tgcaccagca atgacgatca 540
agtgggcatc tggagcggcc ccgcccctca gtgcatt                          577

<210> 21
<211> 577
<212> DNA
<213> Homo sapiens

<400> 21
dcactgtcaa gccccagatc attttctgtt tgccaagttg aaaacccaaa ccaatgcatc 60
tgactttccc attgggacat ctttaaagta cgaatgccgt cctgagtact acgggaggcc 120
attctctatc acatgtctag ataacctggt ctggtcaagt cccaaagatg tctgtaaacg 180
taaatcatgt aaaactcctc cagatccagt gaatggcatg gtgcatgtga tcacagacat 240
ccaggttgga tccagaatca actattcttg tactacaggg caccgactca ttggtcactc 300
atctgctgaa tgtatcctct cgggcaatgc tgcccattgg agcacgaagc cgccaatttg 360
tcaacgaatt ccttgtgggc taccccccac catcgccaat ggagatttca ttagcaccaa 420
cagagagaat tttcactatg gatcagtggt gacctaccgc tgcaatcctg gaagcggagg 480
gagaaaggtg tttgagcttg tgggtgagcc ctccatatac tgcaccagca atgacgatca 540
agtgggcatc tggagcggcc cggcccctca gtgcatt                          577

<210> 22
<211> 1927
<212> DNA
<213> Homo sapiens

<400> 22
dcaatgcaat gccccagaat ggcttccatt tgccaggcct accaacctaa ctgatgaatt 60
tgagtttccc attgggacat atctgaacta tgaatgccgc cctggttatt ccggaagacc 120
gttttctatc atctgcctaa aaaactcagt ctggactggt gctaaggaca ggtgcagacg 180
taaatcatgt cgtaatcctc cagatcctgt gaatggcatg gtgcatgtga tcaaaggcat 240
ccagttcgga tcccaaatta aatattcttg tactaaagga taccgactca ttggttcctc 300
gtctgccaca tgcatcatct caggtgatac tgtcatttgg gataatgaaa cacctatttg 360
tgacagaatt ccttgtgggc taccccccac catcaccaat ggagatttca ttagcaccaa 420
cagagagaat tttcactatg gatcagtggt gacctaccgc tgcaatcctg gaagcggagg 480
gagaaaggtg tttgagcttg tgggtgagcc ctccatatac tgcaccagca atgacgatca 540
agtgggcatc tggagcggcc ccgcccctca gtgcattata cctaacaaat gcacgcctcc 600
aaatgtggaa aatggaatat tggtatctga caacagaagc ttattttcct taaatgaagt 660
tgtggagttt aggtgtcagc ctggctttgt catgaaagga ccccgccgtg tgaagtgcca 720
ggccctgaac aaatgggagc cggagctacc aagctgctcc agggtatgtc agccacctcc 780
agatgtcctg catgctgagc gtacccaaag ggacaaggac aacttttcac ctgggcagga 840
agtgttctac agctgtgagc ccggctacga cctcagaggg gctgcgtcta tgcgctgcac 900
accccaggga gactggagcc ctgcagcccc cacatgtgaa gtgaaatcct gtgatgactt 960
catgggccaa cttcttaatg gccgtgtgct atttccagta aatctccagc ttggagcaaa 1020
agtggatttt gtttgtgatg aaggatttca attaaaaggc agctctgcta gttactgtgt 1080
cttggctgga atggaaagcc tttggaatag cagtgttcca gtgtgtgaac aaatcttttg 1140
tccaagtcct ccagttattc ctaatgggag acacacagga aaacctctgg aagtctttcc 1200
ctttgggaaa acagtaaatt acacatgcga cccccaccca gacagaggga cgagcttcga 1260
cctcattgga gagagcacca tccgctgcac aagtgaccct caagggaatg gggtttggag 1320
cagccctgcc cctcgctgtg gaattctggg tcactgtcaa gccccagatc attttctgtt 1380
tgccaagttg aaaacccaaa ccaatgcatc tgactttccc attgggacat ctttaaagta 1440
cgaatgccgt cctgagtact acgggaggcc attctctatc acatgtctag ataacctggt 1500
ctggtcaagt cccaaagatg tctgtaaacg taaatcatgt aaaactcctc cagatccagt 1560
gaatggcatg gtgcatgtga tcacagacat ccaggttgga tccagaatca actattcttg 1620
tactacaggg caccgactca ttggtcactc atctgctgaa tgtatcctct cgggcaatgc 1680
tgcccattgg agcacgaagc cgccaatttg tcaacgaatt ccttgtgggc taccccccac 1740
catcgccaat ggagatttca ttagcaccaa cagagagaat tttcactatg gatcagtggt 1800
gacctaccgc tgcaatcctg gaagcggagg gagaaaggtg tttgagcttg tgggtgagcc 1860
ctccatatac tgcaccagca atgacgatca agtgggcatc tggagcggcc cggcccctca 1920
gtgcatt                                                           1927

<210> 23
<211> 682
<212> DNA
<213> Homo sapiens

<400> 23
dgacaaaact cacacatgcc caccgtgccc agcacctgaa ctcctggggg gaccgtcagt 60
cttcctcttc cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac 120
atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga 180
cggcgtggag gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta 240
ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa 300
gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa 360
agggcagccc cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa 420
gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga 480
gtgggagagc aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc 540
cgacggctcc ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg 600
gaacgtcttc tcatgctccg tgatgcatga ggctctgcac aaccactata cgcagaagag 660
cctctccctg tctccgggta aa                                          682

<210> 24
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 24
dggaggtgga ggcggtggt                                              19

<210> 25
<211> 58
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 25
datggcctgg atgatgcttc tcctcggact ccttgcttat ggatcaggag tcgactct   58

<210> 26
<211> 67
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 26
datggagaca gacacactcc tgctatgggt actgctgctc tgggttccag ggtcgactgg 60
cgacact                                                           67

<210> 27
<211> 607
<212> DNA
<213> Homo sapiens

<400> 27
dggtagacct ttcgtagaga tgtacagtga aatccccgaa attatacaca tgactgaagg 60
aagggagctc gtcattccct gccgggttac gtcacctaac atcactgtta ctttaaaaaa 120
gtttccactt gacactttga tccctgatgg aaaacgcata atctgggaca gtagaaaggg 180
cttcatcata tcaaatgcaa cgtacaaaga aatagggctt ctgacctgtg aagcaacagt 240
caatgggcat ttgtataaga caaactatct cacacatcga caaaccaata caatcataga 300
tgtggttctg agtccgtctc atggaattga actatctgtt ggagaaaagc ttgtcttaaa 360
ttgtacagca agaactgaac taaatgtggg gattgacttc aactgggaat acccttcttc 420
gaagcatcag cataagaaac ttgtaaaccg agacctaaaa acccagtctg ggagtgagat 480
gaagaaattt ttgagcacct taactataga tggtgtaacc cggagtgacc aaggattgta 540
cacctgtgca gcatccagtg ggctgatgac caagaagaac agcacatttg tcagggtcca 600
tgaaaag                                                           607

<210> 28
<211> 1882
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 28
dggaagacct tttgttgaaa tgtattctga aattcctgaa attattcata tgactgaagg 60
aagagaactt gttattcctt gtagagttac ttctcctaat attactgtta ctcttaagaa 120
gtttcctctt gatactctta ttcctgatgg aaagagaatt atttgggatt ctagaaaggg 180
atttattatt tctaatgcta cttataagga aattggactt cttacttgtg aagctactgt 240
taatggacat ctttataaga ctaattatct tactcataga caaactaata ccatcatcga 300
cgtggttctg agtccgtctc atggaattga actatctgtt ggagaaaagc ttgtcttaaa 360
ttgtacagca agaactgaac taaatgtggg gattgacttc aactgggaat acccttcttc 420
gaagcatcag cataagaaac ttgtaaaccg agacctaaaa acccagtctg ggagtgagat 480
gaagaaattc ttgagcaccc tgactataga tggtgtaacc cggagtgacc aaggattgta 540
cacctgtgca gcatccagtg ggctgatgac caagaagaac agcacatttg tcagggtcca 600
tgaaaaagac aaaactcaca catgtccacc gtgtccagca cctgaactcc tgggtggacc 660
gtcagtcttc ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga 720
ggtcacatgc gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta 780
cgtggacggc gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag 840
cacgtaccgt gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga 900
gtacaagtgc aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa 960
agccaaaggg cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct 1020
gaccaagaac caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc 1080
cgtggagtgg gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct 1140
ggactccgac ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca 1200
gcaggggaac gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca 1260
gaagagcctc tccctgtctc cgggtaaagg tggaggaggc ggtggtcaat gcaatgcccc 1320
agaatggctt ccatttgcca ggcctaccaa cctaactgat gaatttgagt ttcccattgg 1380
gacatatctg aaatatgaat gccgccctgg ttattacgga agaccgtttt ctatcatctg 1440
cctaaaaaac tcagtctgga ctggtgctaa ggacaggtgc agacgtaaat catgtcgtaa 1500
tcctccagat cctgtgaatg gcatggtgca tgtgatcaaa gacatccagt tcggatccca 1560
aattaaatat tcttgtacta aaggataccg actcattggt tcctcgtctg ccacatgcat 1620
catctcaggt aatactgtca tttgggataa tgaaacacct atttgtgaca gaattccttg 1680
tgggctaccc cccaccatca ccaatggaga tttcattagc accaacagag agaattttca 1740
ctatggatca gtggtgacct accgctgcaa tcctggaagc ggagggagaa aggtgtttga 1800
gcttgtgggt gagccctcca tatactgcac cagcaatgac gatcaagtgg gcatctggag 1860
cggccccgca cctcagtgca tt                                          1882

<210> 29
<211> 568
<212> DNA
<213> Homo sapiens

<400> 29
dcgtagctgc gaggtgccaa caaggctaaa ttctgcatcc ctcaaacagc cttatatcac 60
tcagaattat tttccagtcg gtactgttgt ggaatatgag tgccgtccag gttacagaag 120
agaaccttct ctatcaccaa aactaacttg ccttcagaat ttaaaatggt ccacagcagt 180
cgaattttgt aaaaagaaat catgccctaa tccgggagaa atacgaaatg gtcagattga 240
tgtaccaggt ggcatattat ttggtgcaac catctccttc tcatgtaaca cagggtacaa 300
attatttggc tcgacttcta gtttttgtct tatttcaggc agctctgtcc agtggagtga 360
cccgttgcca gagtgcagag aaatttattg tccagcacca ccacaaattg acaatggaat 420
aattcaaggg gaacgtgacc attatggata tagacagtct gtaacgtatg catgtaataa 480
aggattcacc atgattggag agcactctat ttattgtact gtgaataatg atgaaggaga 540
gtggagtggc ccaccacctg aatgcaga                                    568

<210> 30
<211> 568
<212> DNA
<213> Homo sapiens

<400> 30
dagagaaaca tgtccatata tacgggatcc tttaaatggc caagcagtcc ctgcaaatgg 60
gacttacgag tttggttatc agatgcactt tatttgtaat gagggttatt acttaattgg 120
tgaagaaatt ctatattgtg aacttaaagg atcagtagca atttggagcg gtaagccccc 180
aatatgtgaa aaggttttgt gtacaccacc tccaaaaata aaaaatggaa aacacacctt 240
tagtgaagta gaagtatttg agtatcttga tgcagtaact tatagttgtg atcctgcacc 300
tggaccagat ccattttcac ttattggaga gagcacgatt tattgtggtg acaattcagt 360
gtggagtcgt gctgctccag agtgtaaagt ggtcaaatgt cgatttccag tagtcgaaaa 420
tggaaaacag atatcaggat ttggaaaaaa attttactac aaagcaacag ttatgtttga 480
atgcgataag ggtttttacc tcgatggcag cgacacaatt gtctgtgaca gtaacagtac 540
ttgggatccc ccagttccaa agtgtctt                                    568

<210> 31
<211> 736
<212> DNA
<213> Homo sapiens

<400> 31
dgaagattgc aatgaacttc ctccaagaag aaatacagaa attctgacag gttcctggtc 60
tgaccaaaca tatccagaag gcacccaggc tatctataaa tgccgccctg gatatagatc 120
tcttggaaat gtaataatgg tatgcaggaa gggagaatgg gttgctctta atccattaag 180
gaaatgtcag aaaaggccct gtggacatcc tggagatact ccttttggta cttttaccct 240
tacaggagga aatgtgtttg aatatggtgt aaaagctgtg tatacatgta atgaggggta 300
tcaattgcta ggtgagatta attaccgtga atgtgacaca gatggatgga ccaatgatat 360
tcctatatgt gaagttgtga agtgtttacc agtgacagca ccagagaatg gaaaaattgt 420
cagtagtgca atggaaccag atcgggaata ccattttgga caagcagtac ggtttgtatg 480
taactcaggc tacaagattg aaggagatga agaaatgcat tgttcagacg atggtttttg 540
gagtaaagag aaaccaaagt gtgtggaaat ttcatgcaaa tccccagatg ttataaatgg 600
atctcctata tctcagaaga ttatttataa ggagaatgaa cgatttcaat ataaatgtaa 660
catgggttat gaatacagtg aaagaggaga tgctgtatgc actgaatctg gatggcgtcc 720
gttgccttca tgtgaa                                                 736

<210> 32
<211> 562
<212> DNA
<213> Homo sapiens

<400> 32
daattgtggt cctccaccca ctttatcatt tgctgccccg atggatatta cgttgactga 60
gacacgcttc aaaactggaa ctactctgaa atacacctgc ctccctggct acgtcagatc 120
ccattcaact cagacgctta cctgtaattc tgatggcgaa tgggtgtata acaccttctg 180
tatctacaaa cgatgcagac acccaggaga gttacgtaat gggcaagtag agattaagac 240
agatttatct tttggatcac aaatagaatt cagctgttca gaaggatttt tcttaattgg 300
ctcaaccact agtcgttgtg aagtccaaga tagaggagtt ggctggagtc atcctctccc 360
acaatgtgaa attgtcaagt gtaagcctcc tccagacatc aggaatggaa ggcacagcgg 420
tgaagaaaat ttctacgcat acggcttttc tgtcacctac agctgtgacc cccgcttctc 480
actcttgggc catgcctcca tttcttgcac tgtggagaat gaaacaatag gtgtttggag 540
accaagccct cctacctgtg aa                                          562

<210> 33
<211> 634
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 33
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Lys Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Asp
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile Gly Gly Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys
        195                 200                 205             
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
    210                 215                 220                 
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
225                 230                 235                 240 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
                245                 250                 255     
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
            260                 265                 270         
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
        275                 280                 285             
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
    290                 295                 300                 
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
305                 310                 315                 320 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
                325                 330                 335     
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
            340                 345                 350         
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
        355                 360                 365             
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
    370                 375                 380                 
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
385                 390                 395                 400 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
                405                 410                 415     
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Gly Gly
            420                 425                 430         
Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His
        435                 440                 445             
Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro
    450                 455                 460                 
Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro
465                 470                 475                 480 
Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser
                485                 490                 495     
Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val
            500                 505                 510         
Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn
        515                 520                 525             
Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser
    530                 535                 540                 
Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn
545                 550                 555                 560 
Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His
                565                 570                 575     
Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met
            580                 585                 590         
Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp
        595                 600                 605             
Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys
    610                 615                 620                 
Asn Ser Thr Phe Val Arg Val His Glu Lys
625                 630                 


<210> 34
<211> 628
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 34
Pro Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
 1               5                  10                  15      
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Lys Tyr Glu
            20                  25                  30          
Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
        35                  40                  45              
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
    50                  55                  60                  
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Asp
65                  70                  75                  80  
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
                85                  90                  95      
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val
            100                 105                 110         
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
        115                 120                 125             
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
    130                 135                 140                 
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
145                 150                 155                 160 
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
                165                 170                 175     
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
            180                 185                 190         
Ile Gly Gly Gly Gly Gly Gly Gly Arg Pro Phe Val Glu Met Tyr Ser
        195                 200                 205             
Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile
    210                 215                 220                 
Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe
225                 230                 235                 240 
Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser
                245                 250                 255     
Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu
            260                 265                 270         
Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr
        275                 280                 285             
Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro
    290                 295                 300                 
Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys
305                 310                 315                 320 
Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr
                325                 330                 335     
Pro Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys
            340                 345                 350         
Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile
        355                 360                 365             
Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser
    370                 375                 380                 
Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu
385                 390                 395                 400 
Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
                405                 410                 415     
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            420                 425                 430         
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        435                 440                 445             
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    450                 455                 460                 
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
465                 470                 475                 480 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                485                 490                 495     
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            500                 505                 510         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        515                 520                 525             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
    530                 535                 540                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
545                 550                 555                 560 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                565                 570                 575     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            580                 585                 590         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        595                 600                 605             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    610                 615                 620                 
Ser Pro Gly Lys
625             


<210> 35
<211> 633
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 35
Pro Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile
 1               5                  10                  15      
His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser
            20                  25                  30          
Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile
        35                  40                  45              
Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile
    50                  55                  60                  
Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr
65                  70                  75                  80  
Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr
                85                  90                  95      
Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu
            100                 105                 110         
Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu
        115                 120                 125             
Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln
    130                 135                 140                 
His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu
145                 150                 155                 160 
Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser
                165                 170                 175     
Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys
            180                 185                 190         
Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Gly Gly Gly Gly Gly
        195                 200                 205             
Gly Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe Ala Arg Pro Thr Asn
    210                 215                 220                 
Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr Tyr Leu Lys Tyr Glu
225                 230                 235                 240 
Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser Ile Ile Cys Leu Lys
                245                 250                 255     
Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys Arg Arg Lys Ser Cys
            260                 265                 270         
Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val His Val Ile Lys Asp
        275                 280                 285             
Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys Thr Lys Gly Tyr Arg
    290                 295                 300                 
Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile Ser Gly Asn Thr Val
305                 310                 315                 320 
Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg Ile Pro Cys Gly Leu
                325                 330                 335     
Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn
            340                 345                 350         
Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly
        355                 360                 365             
Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr
    370                 375                 380                 
Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys
385                 390                 395                 400 
Ile Gly Gly Gly Gly Gly Gly Asp Lys Thr His Thr Cys Pro Pro Cys
                405                 410                 415     
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
            420                 425                 430         
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
        435                 440                 445             
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
    450                 455                 460                 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
465                 470                 475                 480 
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
                485                 490                 495     
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
            500                 505                 510         
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
        515                 520                 525             
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu
    530                 535                 540                 
Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
545                 550                 555                 560 
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
                565                 570                 575     
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
            580                 585                 590         
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
        595                 600                 605             
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
    610                 615                 620                 
Gln Lys Ser Leu Ser Leu Ser Pro Gly
625                 630             


<210> 36
<211> 633
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 36
Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
 1               5                  10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Gly Gly Gly Gly Gly Gly Gly Arg Pro Phe Val Glu Met
225                 230                 235                 240 
Tyr Ser Glu Ile Pro Glu Ile Ile His Met Thr Glu Gly Arg Glu Leu
                245                 250                 255     
Val Ile Pro Cys Arg Val Thr Ser Pro Asn Ile Thr Val Thr Leu Lys
            260                 265                 270         
Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp
        275                 280                 285             
Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile
    290                 295                 300                 
Gly Leu Leu Thr Cys Glu Ala Thr Val Asn Gly His Leu Tyr Lys Thr
305                 310                 315                 320 
Asn Tyr Leu Thr His Arg Gln Thr Asn Thr Ile Ile Asp Val Val Leu
                325                 330                 335     
Ser Pro Ser His Gly Ile Glu Leu Ser Val Gly Glu Lys Leu Val Leu
            340                 345                 350         
Asn Cys Thr Ala Arg Thr Glu Leu Asn Val Gly Ile Asp Phe Asn Trp
        355                 360                 365             
Glu Tyr Pro Ser Ser Lys His Gln His Lys Lys Leu Val Asn Arg Asp
    370                 375                 380                 
Leu Lys Thr Gln Ser Gly Ser Glu Met Lys Lys Phe Leu Ser Thr Leu
385                 390                 395                 400 
Thr Ile Asp Gly Val Thr Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala
                405                 410                 415     
Ala Ser Ser Gly Leu Met Thr Lys Lys Asn Ser Thr Phe Val Arg Val
            420                 425                 430         
His Glu Lys Gly Gly Gly Gly Gly Gly Gln Cys Asn Ala Pro Glu Trp
        435                 440                 445             
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro
    450                 455                 460                 
Ile Gly Thr Tyr Leu Lys Tyr Glu Cys Arg Pro Gly Tyr Tyr Gly Arg
465                 470                 475                 480 
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys
                485                 490                 495     
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn
            500                 505                 510         
Gly Met Val His Val Ile Lys Asp Ile Gln Phe Gly Ser Gln Ile Lys
        515                 520                 525             
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr
    530                 535                 540                 
Cys Ile Ile Ser Gly Asn Thr Val Ile Trp Asp Asn Glu Thr Pro Ile
545                 550                 555                 560 
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp
                565                 570                 575     
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr
            580                 585                 590         
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val
        595                 600                 605             
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile
    610                 615                 620                 
Trp Ser Gly Pro Ala Pro Gln Cys Ile
625                 630             


<210> 37
<211> 633
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 37
Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
 1               5                  10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Gly Gly Gly Gly Gly Gly Gln Cys Asn Ala Pro Glu Trp
225                 230                 235                 240 
Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro
                245                 250                 255     
Ile Gly Thr Tyr Leu Lys Tyr Glu Cys Arg Pro Gly Tyr Tyr Gly Arg
            260                 265                 270         
Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys
        275                 280                 285             
Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn
    290                 295                 300                 
Gly Met Val His Val Ile Lys Asp Ile Gln Phe Gly Ser Gln Ile Lys
305                 310                 315                 320 
Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr
                325                 330                 335     
Cys Ile Ile Ser Gly Asn Thr Val Ile Trp Asp Asn Glu Thr Pro Ile
            340                 345                 350         
Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp
        355                 360                 365             
Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr
    370                 375                 380                 
Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val
385                 390                 395                 400 
Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile
                405                 410                 415     
Trp Ser Gly Pro Ala Pro Gln Cys Ile Gly Gly Gly Gly Gly Gly Gly
            420                 425                 430         
Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu Ile Ile His Met
        435                 440                 445             
Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val Thr Ser Pro Asn
    450                 455                 460                 
Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr Leu Ile Pro Asp
465                 470                 475                 480 
Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe Ile Ile Ser Asn
                485                 490                 495     
Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu Ala Thr Val Asn
            500                 505                 510         
Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg Gln Thr Asn Thr
        515                 520                 525             
Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile Glu Leu Ser Val
    530                 535                 540                 
Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr Glu Leu Asn Val
545                 550                 555                 560 
Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys His Gln His Lys
                565                 570                 575     
Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly Ser Glu Met Lys
            580                 585                 590         
Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr Arg Ser Asp Gln
        595                 600                 605             
Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met Thr Lys Lys Asn
    610                 615                 620                 
Ser Thr Phe Val Arg Val His Glu Lys
625                 630             


<210> 38
<211> 205
<212> PRT
<213> Homo sapiens

<400> 38
Pro Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
 1               5                  10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
                85                  90                  95      
Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile
            100                 105                 110         
Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr
        115                 120                 125             
Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys
    130                 135                 140                 
His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly
145                 150                 155                 160 
Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr
                165                 170                 175     
Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met
            180                 185                 190         
Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys
        195                 200                 205 


<210> 39
<211> 228
<212> PRT
<213> Homo sapiens

<400> 39
Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
 1               5                  10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Lys
225             


<210> 40
<211> 630
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 40
Pro Asp Thr Gly Arg Pro Phe Val Glu Met Tyr Ser Glu Ile Pro Glu
 1               5                  10                  15      
Ile Ile His Met Thr Glu Gly Arg Glu Leu Val Ile Pro Cys Arg Val
            20                  25                  30          
Thr Ser Pro Asn Ile Thr Val Thr Leu Lys Lys Phe Pro Leu Asp Thr
        35                  40                  45              
Leu Ile Pro Asp Gly Lys Arg Ile Ile Trp Asp Ser Arg Lys Gly Phe
    50                  55                  60                  
Ile Ile Ser Asn Ala Thr Tyr Lys Glu Ile Gly Leu Leu Thr Cys Glu
65                  70                  75                  80  
Ala Thr Val Asn Gly His Leu Tyr Lys Thr Asn Tyr Leu Thr His Arg
                85                  90                  95      
Gln Thr Asn Thr Ile Ile Asp Val Val Leu Ser Pro Ser His Gly Ile
            100                 105                 110         
Glu Leu Ser Val Gly Glu Lys Leu Val Leu Asn Cys Thr Ala Arg Thr
        115                 120                 125             
Glu Leu Asn Val Gly Ile Asp Phe Asn Trp Glu Tyr Pro Ser Ser Lys
    130                 135                 140                 
His Gln His Lys Lys Leu Val Asn Arg Asp Leu Lys Thr Gln Ser Gly
145                 150                 155                 160 
Ser Glu Met Lys Lys Phe Leu Ser Thr Leu Thr Ile Asp Gly Val Thr
                165                 170                 175     
Arg Ser Asp Gln Gly Leu Tyr Thr Cys Ala Ala Ser Ser Gly Leu Met
            180                 185                 190         
Thr Lys Lys Asn Ser Thr Phe Val Arg Val His Glu Lys Asp Lys Thr
        195                 200                 205             
His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
    210                 215                 220                 
Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
225                 230                 235                 240 
Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro
                245                 250                 255     
Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala
            260                 265                 270         
Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val
        275                 280                 285             
Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
    290                 295                 300                 
Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
305                 310                 315                 320 
Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu
                325                 330                 335     
Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys
            340                 345                 350         
Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser
        355                 360                 365             
Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp
    370                 375                 380                 
Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser
385                 390                 395                 400 
Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala
                405                 410                 415     
Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
            420                 425                 430         
Gly Gly Gly Gly Gly Gly Gln Cys Asn Ala Pro Glu Trp Leu Pro Phe
        435                 440                 445             
Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro Ile Gly Thr
    450                 455                 460                 
Tyr Leu Lys Tyr Glu Cys Arg Pro Gly Tyr Tyr Gly Arg Pro Phe Ser
465                 470                 475                 480 
Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys Asp Arg Cys
                485                 490                 495     
Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn Gly Met Val
            500                 505                 510         
His Val Ile Lys Asp Ile Gln Phe Gly Ser Gln Ile Lys Tyr Ser Cys
        515                 520                 525             
Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr Cys Ile Ile
    530                 535                 540                 
Ser Gly Asn Thr Val Ile Trp Asp Asn Glu Thr Pro Ile Cys Asp Arg
545                 550                 555                 560 
Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp Phe Ile Ser
                565                 570                 575     
Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr Tyr Arg Cys
            580                 585                 590         
Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val Gly Glu Pro
        595                 600                 605             
Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile Trp Ser Gly
    610                 615                 620                 
Pro Ala Pro Gln Cys Ile
625                 630 


<210> 41
<211> 228
<212> PRT
<213> Homo sapiens

<400> 41
Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
 1               5                  10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr
65                  70                  75                  80  
Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            100                 105                 110         
Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Lys
225             


<210> 42
<211> 228
<212> PRT
<213> Homo sapiens

<400> 42
Pro Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
 1               5                  10                  15      
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
            20                  25                  30          
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
        35                  40                  45              
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
    50                  55                  60                  
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
65                  70                  75                  80  
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                85                  90                  95      
Gly Lys Asp Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
            100                 105                 110         
Met Gln Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
        115                 120                 125             
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
    130                 135                 140                 
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Arg His Ile Ala Val
145                 150                 155                 160 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                165                 170                 175     
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
            180                 185                 190         
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
        195                 200                 205             
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
    210                 215                 220                 
Ser Pro Gly Lys
225             


<210> 43
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 43
Pro Met Glu Thr Asp Thr Leu Leu Leu Trp Val Leu Leu Leu Trp Val
 1               5                  10                  15      
Pro Gly Ser Thr Gly
            20      

