                         SEQUENCE LISTING

<110>  Integrated Biotherapeutics, Inc.
 
<120>  Immunogenic Composition Comprising Panton-Valentine Leukocidin 
       (PVL) Derived Polypeptides

<130>  2877.008PC01

<140>  To Be Assigned
<141>  Herewith

<150>  US 61/566,234
<151>  2011-12-02

<160>  137   

<170>  PatentIn version 3.5

<210>  1
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukS-PV amino acid consensus sequence A


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  X can be Glu, Gln, or may be missing

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X can be Asp, Gly, or may be missing

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X can be Thr, Lys, Ile, Val, or may be missing

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X can be Ser, Thr, Ala, or may be missing

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X can be Asp, Lys, Asn, Arg, or may be missing

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  X can be Lys, Arg, or may be missing

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X can be Trp, Leu, or may be missing

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X can be Gly, Ala, or may be missing

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X can be Val, Ile, or may be missing

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  X can be Ile, Val, or may be missing

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  X can be Asp, Gly, or may be missing

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  X can be Val or Met

<220>
<221>  misc_feature
<222>  (22)..(22)
<223>  X can be Lys, Thr, or Pro

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  X can be Asp, Asn, or Val

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  X can be Ile or Val

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  X can be Leu, Val, or Ile

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  X can be Asn, Ser, or Lys

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  X can be Lys or Arg

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  X can be Thr, Ser, or Ala

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X can be Tyr or Phe

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X can be Tyr, Ser, Asn, or Thr

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  X can be Asn or Asp

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  X can be Tyr, Val, Leu, Phe, or Ser

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  X can be Asn, Lys, Gly, or Gln

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  X can be Thr, Tyr, Ser, Asn, Lys, or Arg

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  X can be Gly or may be missing

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  X can be Tyr or may be missing

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X can be Asp, Asn, Glu, Pro, or Arg

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X can be His, Tyr, Leu, or Ala

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  X can be Ile, Thr, Val, or Asn

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  X can be Ala, Arg, or Ser

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  X can be Met, Ile, or Leu

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  X can be Arg, Ile, Val, or Leu

<400>  1

Xaa Xaa Xaa Xaa Ser Xaa Xaa Xaa Xaa Xaa Thr Gln Asn Xaa Gln Phe 
1               5                   10                  15      


Xaa Phe Xaa Lys Asp Xaa Lys Tyr Asn Lys Xaa Ala Leu Xaa Xaa Lys 
            20                  25                  30          


Met Gln Gly Phe Ile Xaa Ser Xaa Thr Xaa Xaa Xaa Xaa Xaa Lys Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Lys Xaa Xaa Xaa Trp Pro 
    50                  55                  60  


<210>  2
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukS-PV amino acid consensus sequence B


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X can be Gly, Ser, or Ala

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  X can be Lys, Thr, Ser, or Met

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  X can be Thr or Ser

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  X can be Asn or Lys

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X can be Pro, Lys, Ser, or Gln

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  X can be Asn or Tyr

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  X can be Val, Thr, or Ile

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  X can be Asp, Ser, or Phe

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  X can be Ser or may be missing

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  X can be Ile or may be missing

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  X can be Tyr, His, or Thr

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  X can be Asn or Thr

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  X can be Asp or Glu

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  X can be Ser or Thr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  X can be Val, Thr, Ala, or Ile

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  X can be Asn or Asp

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  X can be Ser or Gly

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  X can be Thr or Lys

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  X can be Ile or Val

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  X can be Gly or may be missing

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X can be Asn, Lys, or may be missing

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X can be Phe or may be missing

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  X can be Asn, Gln, or may be missing

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  X can be Ser, Thr, or may be missing

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  X can be Gly, Ala, Val, or may be missing

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  X can be Pro or may be missing

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  X can be Ser, Leu, or may be missing

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  X can be Thr, Leu, Ile, or may be missing

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  X can be Gly, Ala, or may be missing

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X can be Asn, Ser, or Lys

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  X can be Ser, Ala, or Glu

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  X can be Asn or Ser

<400>  2

Phe Gln Tyr Asn Ile Xaa Leu Xaa Xaa Xaa Asp Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Ile Asn Xaa Xaa Xaa Leu Pro Lys Xaa Lys Ile Xaa Xaa Xaa Xaa Val 
            20                  25                  30          


Xaa Gln Xaa Leu Gly Tyr Asn Xaa Gly Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Gly Xaa Gly Xaa Phe Xaa Tyr Ser Lys 
    50                  55                  60  


<210>  3
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukS-PV amino acid consensus sequence C


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X can be Val or Ala

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  X can be Pro or Asp

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X can be Asp or Asn

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  X can be Asn, Ser, or Asp

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  X can be Glu or Gln

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  X can be Val or Ile

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  X can be His, Gln, or Thr

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  X can be Ala or Thr

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  X can be Val or Leu

<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  X can be Lys or Arg

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  X can be Gly or Asp

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  X can be Ser, Lys, or Thr

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  X can be Gly, Ser, or Lys

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  X can be Asp, Glu, or Leu

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  X can be Thr, Lys, or Ile

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  X can be Arg or may be missing

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  X can be Ser or Val

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  X can be Glu, Asp, or Asn

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  X can be Phe or Leu

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  X can be Glu or Lys

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  X can be Ile or Phe

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  X can be Thr, Ser, or Ala

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  X can be Met or Leu

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  X can be Val, Ala, Ile, or Thr

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  X can be His or Tyr

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  X can be Thr, Ile, or Tyr

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  X can be Arg, Lys, Val, Leu, or Phe

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  X can be Arg, Thr, Phe, or Leu

<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  X can be Thr, Ser, Arg, or Pro

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  X can be Thr, His, Arg, Lys, or Pro

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  X can be His, Arg, Thr, Leu, or Gln

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  X can be Tyr or may be missing

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  X can be Gly or may be missing

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  X can be Asn or may be missing

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  X can be Ser or may be missing

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  X can be Tyr or Gly

<400>  3

Phe Xaa Xaa Xaa Xaa Xaa Leu Pro Pro Leu Xaa Xaa Ser Gly Phe Asn 
1               5                   10                  15      


Pro Ser Phe Ile Xaa Thr Xaa Ser His Glu Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Gly Arg Asn Xaa Asp Xaa Thr Xaa 
        35                  40                  45              


Ala Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210>  4
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid consensus sequence


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  X can be Val, Ile, or Ala

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  X can be Asp or His

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  X can be Asn or Gln

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  X can be Leu or Val

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  X can be Ser or Thr

<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  X can be Phe or Tyr

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  X can be Ser or Asn

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  X can be Ser, Ile, Asn, or Thr

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  X can be Lys or Asn

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  X can be Ser or Thr

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  X can be Leu or Gly

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  X can be Ser or Asn

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  X can be Glu, Thr, or Lys

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  X can be Ser or Ala

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  X can be Thr or may be missing

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  X can be Thr or Ser

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  X can be Ile or Leu

<220>
<221>  misc_feature
<222>  (60)..(60)
<223>  X can be Asp or Ser

<400>  4

Asn Xaa Val Xaa Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val 
1               5                   10                  15      


Gln Xaa Thr Xaa Gly Tyr Xaa Xaa Gly Gly Asp Ile Xaa Ile Xaa Xaa 
            20                  25                  30          


Gly Leu Xaa Gly Gly Xaa Asn Gly Xaa Xaa Xaa Phe Ser Glu Thr Ile 
        35                  40                  45              


Asn Tyr Lys Gln Glu Ser Tyr Arg Xaa Xaa Xaa Xaa 
    50                  55                  60  


<210>  5
<211>  312
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukS-PV amino acid sequence (with signal peptide)

<400>  5

Met Val Lys Lys Arg Leu Leu Ala Ala Thr Leu Ser Leu Gly Ile Ile 
1               5                   10                  15      


Thr Pro Ile Ala Thr Ser Phe His Glu Ser Lys Ala Asp Asn Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg Thr Glu Asp Thr 
        35                  40                  45              


Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys Asn Thr Asp His 
                85                  90                  95      


Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly Leu Lys Thr 
            100                 105                 110         


Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile 
        115                 120                 125             


Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn 
    130                 135                 140                 


Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser Phe Asn Tyr Ser 
145                 150                 155                 160 


Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser Glu Val Glu His 
                165                 170                 175     


Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala Asn Ser Phe Ile 
            180                 185                 190         


Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn Leu Phe Val Gly 
        195                 200                 205             


Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro Ser Phe Ile Ala 
225                 230                 235                 240 


Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr Arg Arg Thr Thr 
            260                 265                 270         


His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile His Asn Ala Phe 
        275                 280                 285             


Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His 
    290                 295                 300                 


Glu Ile Lys Val Lys Gly His Asn 
305                 310         


<210>  6
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukS-PV amino acid sequence (without signal peptide)

<400>  6

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  7
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Lys97Ala (K97A)

<400>  7

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Ala Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  8
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Asp101Ala (D101A)

<400>  8

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Ala Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  9
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Tyr131Ala (Y131A)

<400>  9

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Ala Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  10
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Ser209Ala (S209A)

<400>  10

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ala Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  11
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Thr28Phe (T28F)

<400>  11

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Phe Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  12
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LukS-PV amino acid sequence-Thr28Phe/Tyr131Ala (T28F/Y131A)

<400>  12

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Phe Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Ala Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  13
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Thr28Phe/Ser209Ala 
       (T28F/S209A)

<400>  13

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Phe Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Lys Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ala Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  14
<211>  284
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukS-PV amino acid sequence-Thr28Phe/Lys97Ala/Ser209Ala 
       (T28F/K97A/S209A)

<400>  14

Asp Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg 
1               5                   10                  15      


Thr Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Phe Gln Asn Ile Gln 
            20                  25                  30          


Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu 
        35                  40                  45              


Lys Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys 
    50                  55                  60                  


Asn Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile 
65                  70                  75                  80  


Gly Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro 
                85                  90                  95      


Ala Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn 
            100                 105                 110         


Ile Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser 
        115                 120                 125             


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser 
    130                 135                 140                 


Glu Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala 
145                 150                 155                 160 


Asn Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn 
                165                 170                 175     


Leu Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe 
            180                 185                 190         


Val Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro 
        195                 200                 205             


Ala Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser 
    210                 215                 220                 


Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr 
225                 230                 235                 240 


Arg Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile 
                245                 250                 255     


His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn 
            260                 265                 270         


Trp Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
        275                 280                 


<210>  15
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukS-PV amino acid sequence

<400>  15

Met Val Lys Lys Arg Leu Leu Ala Ala Thr Leu Ser Leu Gly Ile Ile 
1               5                   10                  15      


Thr Pro Ile Ala Thr Ser Phe His Glu Ser Lys Ala Asp Asn Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg Thr Glu Asp Thr 
        35                  40                  45              


Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys Asn Thr Asp His 
                85                  90                  95      


Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly Leu Lys Thr 
            100                 105                 110         


Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile 
        115                 120                 125             


Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn 
    130                 135                 140                 


Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser Phe Asn Tyr Ser 
145                 150                 155                 160 


Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser Glu Val Glu Arg 
                165                 170                 175     


Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala Asn Ser Phe Ile 
            180                 185                 190         


Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn Leu Phe Val Gly 
        195                 200                 205             


Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro Ser Phe Ile Ala 
225                 230                 235                 240 


Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu Phe Glu Ile Thr 
                245                 250                 255     


Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr Arg Arg Thr Thr His 
            260                 265                 270         


Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  16
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence (with signal peptide)

<400>  16

Met Lys Lys Ile Val Lys Ser Ser Val Val Thr Ser Ile Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro Val Ser 
            20                  25                  30          


Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr Ala Thr 
        35                  40                  45              


Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe Asn Phe 
    50                  55                  60                  


Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys Ala Ala 
65                  70                  75                  80  


Gly Asn Ile Tyr Ser Gly Tyr Thr Lys Pro Asn Pro Lys Asp Thr Ile 
                85                  90                  95      


Ser Ser Gln Phe Tyr Trp Gly Ser Lys Tyr Asn Ile Ser Ile Asn Ser 
            100                 105                 110         


Asp Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys Asn Gln 
        115                 120                 125             


Asn Glu Glu Phe Gln Val Gln Gln Thr Val Gly Tyr Ser Tyr Gly Gly 
    130                 135                 140                 


Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Gly Asn Gly Ser Lys 
145                 150                 155                 160 


Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr Ser 
                165                 170                 175     


Leu Asp Lys Arg Thr Asn Phe Lys Lys Ile Gly Trp Asp Val Glu Ala 
            180                 185                 190         


His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Tyr 
        195                 200                 205             


His Ser Thr Tyr Gly Asn Glu Met Phe Leu Gly Ser Arg Gln Ser Asn 
    210                 215                 220                 


Leu Asn Ala Gly Gln Asn Phe Leu Glu Tyr His Lys Met Pro Val Leu 
225                 230                 235                 240 


Ser Arg Gly Asn Phe Asn Pro Glu Phe Ile Gly Val Leu Ser Arg Lys 
                245                 250                 255     


Gln Asn Ala Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln Arg Glu 
            260                 265                 270         


Met Asp Arg Tyr Thr Asn Phe Trp Asn Gln Leu His Trp Ile Gly Asn 
        275                 280                 285             


Asn Tyr Lys Asp Glu Asn Arg Ala Thr His Thr Ser Ile Tyr Glu Val 
    290                 295                 300                 


Asp Trp Glu Asn His Thr Val Lys Leu Ile Asp Thr Gln Ser Lys Glu 
305                 310                 315                 320 


Lys Asn Pro Met Ser 
                325 


<210>  17
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence (without signal peptide)

<400>  17

Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      


Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile 
            20                  25                  30          


Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              


Asp Thr Leu Ile Leu Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr 
    50                  55                  60                  


Lys Pro Asn Pro Lys Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser 
65                  70                  75                  80  


Lys Tyr Asn Ile Ser Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val 
                85                  90                  95      


Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         


Thr Val Gly Tyr Ser Tyr Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             


Ser Gly Gly Gly Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 


Lys Gln Glu Ser Tyr Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys 
145                 150                 155                 160 


Lys Ile Gly Trp Asp Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     


Gly Pro Tyr Gly Arg Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met 
            180                 185                 190         


Phe Leu Gly Ser Arg Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             


Glu Tyr His Lys Met Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 


Phe Ile Gly Val Leu Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys 
225                 230                 235                 240 


Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp 
                245                 250                 255     


Asn Gln Leu His Trp Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala 
            260                 265                 270         


Thr His Thr Ser Ile Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys 
        275                 280                 285             


Leu Ile Asp Thr Gln Ser Lys Glu Lys Asn Pro Met Ser 
    290                 295                 300     


<210>  18
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukF-PV amino acid sequence-Lys102Ala (K102A)

<400>  18

Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      


Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile 
            20                  25                  30          


Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              


Asp Thr Leu Ile Leu Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr 
    50                  55                  60                  


Lys Pro Asn Pro Lys Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser 
65                  70                  75                  80  


Lys Tyr Asn Ile Ser Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val 
                85                  90                  95      


Val Asp Tyr Ala Pro Ala Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         


Thr Val Gly Tyr Ser Tyr Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             


Ser Gly Gly Gly Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 


Lys Gln Glu Ser Tyr Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys 
145                 150                 155                 160 


Lys Ile Gly Trp Asp Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     


Gly Pro Tyr Gly Arg Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met 
            180                 185                 190         


Phe Leu Gly Ser Arg Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             


Glu Tyr His Lys Met Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 


Phe Ile Gly Val Leu Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys 
225                 230                 235                 240 


Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp 
                245                 250                 255     


Asn Gln Leu His Trp Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala 
            260                 265                 270         


Thr His Thr Ser Ile Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys 
        275                 280                 285             


Leu Ile Asp Thr Gln Ser Lys Glu Lys Asn Pro Met Ser 
    290                 295                 300     


<210>  19
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukF-PV amino acid sequence-Asp121Ala (D121A)

<400>  19

Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      


Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile 
            20                  25                  30          


Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              


Asp Thr Leu Ile Leu Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr 
    50                  55                  60                  


Lys Pro Asn Pro Lys Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser 
65                  70                  75                  80  


Lys Tyr Asn Ile Ser Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val 
                85                  90                  95      


Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         


Thr Val Gly Tyr Ser Tyr Gly Gly Ala Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             


Ser Gly Gly Gly Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 


Lys Gln Glu Ser Tyr Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys 
145                 150                 155                 160 


Lys Ile Gly Trp Asp Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     


Gly Pro Tyr Gly Arg Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met 
            180                 185                 190         


Phe Leu Gly Ser Arg Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             


Glu Tyr His Lys Met Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 


Phe Ile Gly Val Leu Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys 
225                 230                 235                 240 


Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp 
                245                 250                 255     


Asn Gln Leu His Trp Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala 
            260                 265                 270         


Thr His Thr Ser Ile Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys 
        275                 280                 285             


Leu Ile Asp Thr Gln Ser Lys Glu Lys Asn Pro Met Ser 
    290                 295                 300     


<210>  20
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  mutant LukF-PV amino acid sequence-Glu147Ala (E147A)

<400>  20

Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      


Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile 
            20                  25                  30          


Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              


Asp Thr Leu Ile Leu Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr 
    50                  55                  60                  


Lys Pro Asn Pro Lys Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser 
65                  70                  75                  80  


Lys Tyr Asn Ile Ser Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val 
                85                  90                  95      


Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         


Thr Val Gly Tyr Ser Tyr Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             


Ser Gly Gly Gly Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 


Lys Gln Ala Ser Tyr Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys 
145                 150                 155                 160 


Lys Ile Gly Trp Asp Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     


Gly Pro Tyr Gly Arg Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met 
            180                 185                 190         


Phe Leu Gly Ser Arg Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             


Glu Tyr His Lys Met Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 


Phe Ile Gly Val Leu Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys 
225                 230                 235                 240 


Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp 
                245                 250                 255     


Asn Gln Leu His Trp Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala 
            260                 265                 270         


Thr His Thr Ser Ile Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys 
        275                 280                 285             


Leu Ile Asp Thr Gln Ser Lys Glu Lys Asn Pro Met Ser 
    290                 295                 300     


<210>  21
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  21

Met Lys Lys Ile Val Lys Ser Ser Val Val Thr Ser Ile Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro Val Ser 
            20                  25                  30          


Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr Ala Thr 
        35                  40                  45              


Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe Asn Phe 
    50                  55                  60                  


Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys Ala Ala 
65                  70                  75                  80  


Gly Asn Ile Tyr Ser Gly Tyr Thr Lys Pro Asn Pro Lys Asp Thr Ile 
                85                  90                  95      


Ser Ser Gln Phe Tyr Trp Gly Ser Lys Tyr Asn Ile Ser Ile Asn Ser 
            100                 105                 110         


Asp Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys Asn Gln 
        115                 120                 125             


Asn Glu Glu Phe Gln Val Gln Gln Thr Val Gly Tyr Ser Tyr Gly Gly 
    130                 135                 140                 


Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Gly Asn Gly Ser Lys 
145                 150                 155                 160 


Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr Ser 
                165                 170                 175     


Leu Asp Lys Arg Thr Asn Phe Lys Lys Ile Gly Trp Asp Val Glu Ala 
            180                 185                 190         


His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Tyr 
        195                 200                 205             


His Ser Thr Tyr Gly Asn Glu Met Phe Leu Gly Ser Arg Gln Ser Asn 
    210                 215                 220                 


Leu Asn Ala Gly Gln Asn Phe Leu Glu Tyr His Lys Met Pro Val Leu 
225                 230                 235                 240 


Ser Arg Gly Asn Phe Asn Pro Glu Phe Ile Gly Val Leu Ser Arg Lys 
                245                 250                 255     


Gln Asn Ala Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln Arg Glu 
            260                 265                 270         


Met Asp Arg Tyr Thr Asn Phe Trp Asn Gln Leu His Trp Ile Gly Asn 
        275                 280                 285             


Asn Tyr Lys Asp Glu Asn Arg Ala Thr His Thr Ser Ile Tyr Glu Val 
    290                 295                 300                 


Asp Trp Glu Asn His Thr Val Lys Leu Ile Asp Thr Gln Ser Lys Glu 
305                 310                 315                 320 


Lys Asn Pro 
            


<210>  22
<211>  328
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  22

Met Lys Lys Ile Val Lys Ser Ser Val Val Thr Ser Ile Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro Val Ser 
            20                  25                  30          


Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr Ala Thr 
        35                  40                  45              


Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe Asn Phe 
    50                  55                  60                  


Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys Ala Ala 
65                  70                  75                  80  


Gly Asn Ile Tyr Ser Gly Tyr Thr Lys Pro Asn Pro Lys Asp Thr Ile 
                85                  90                  95      


Ser Ser Gln Phe Tyr Trp Gly Ser Lys Tyr Asn Ile Ser Ile Asn Ser 
            100                 105                 110         


Asp Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys Asn Gln 
        115                 120                 125             


Asn Glu Glu Phe Gln Val Gln Gln Thr Val Gly Tyr Ser Tyr Gly Gly 
    130                 135                 140                 


Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Gly Asn Gly Ser Lys 
145                 150                 155                 160 


Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr Ser 
                165                 170                 175     


Leu Asp Lys Arg Thr Asn Phe Lys Lys Ile Gly Trp Asp Val Glu Ala 
            180                 185                 190         


His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Tyr 
        195                 200                 205             


His Ser Thr Tyr Gly Asn Glu Met Phe Leu Gly Ser Arg Gln Ser Asn 
    210                 215                 220                 


Leu Asn Ala Gly Gln Asn Phe Leu Glu Tyr His Lys Met Pro Val Leu 
225                 230                 235                 240 


Ser Arg Gly Asn Phe Asn Pro Glu Phe Ile Gly Val Leu Ser Arg Lys 
                245                 250                 255     


Gln Asn Ala Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln Arg Glu 
            260                 265                 270         


Met Asp Arg Tyr Thr Asn Phe Trp Asn Gln Leu His Trp Ile Gly Asn 
        275                 280                 285             


Asn Tyr Lys Asp Glu Asn Arg Ala Thr His Thr Ser Ile Tyr Glu Val 
    290                 295                 300                 


Asp Trp Glu Asn His Thr Val Lys Leu Ile Asp Thr Gln Ser Lys Glu 
305                 310                 315                 320 


Lys Lys Ser Tyr Glu Leu Asn Arg 
                325             


<210>  23
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  23

Met Lys Lys Ile Val Lys Ser Ser Val Val Thr Ser Ile Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro Val Ser 
            20                  25                  30          


Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr Ala Thr 
        35                  40                  45              


Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe Asn Phe 
    50                  55                  60                  


Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys Ala Ala 
65                  70                  75                  80  


Gly Asn Ile Tyr Ser Gly Tyr Thr Lys Pro Asn Pro Lys Asp Thr Ile 
                85                  90                  95      


Ser Ser Gln Phe Tyr Trp Gly Ser Lys Tyr Asn Ile Ser Ile Asn Ser 
            100                 105                 110         


Asp Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys Asn Gln 
        115                 120                 125             


Asn Glu Glu Phe Gln Val Gln Gln Thr Val Gly Tyr Ser Tyr Gly Gly 
    130                 135                 140                 


Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Gly Asn Gly Ser Lys 
145                 150                 155                 160 


Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr Ser 
                165                 170                 175     


Leu Asp Lys Arg Thr Asn Phe Lys Lys Ile Gly Trp Asp Val Glu Ala 
            180                 185                 190         


His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Tyr 
        195                 200                 205             


His Ser Thr Tyr Gly Asn Glu Met Phe Leu Gly Ser Arg Gln Ser Asn 
    210                 215                 220                 


Leu Asn Ala Gly Gln Asn Phe Leu Glu Tyr His Lys Met Pro Val Leu 
225                 230                 235                 240 


Ser Arg Gly Asn Phe Asn Pro Glu Phe Ile Gly Val Leu Ser Arg Lys 
                245                 250                 255     


Gln Asn Ala Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln Arg Glu 
            260                 265                 270         


Met Asp Arg Tyr Thr Asn Phe Trp Ile Asn Phe Asn Trp Ile Gly Asn 
        275                 280                 285             


Asn Tyr Lys Asp Glu Asn Arg Ala Thr His Thr Ser Ile Tyr Glu Val 
    290                 295                 300                 


Asp Trp Glu Asn His Thr Val Lys Leu Ile Asp Thr Gln Ser Lys Glu 
305                 310                 315                 320 


Lys Asn Pro Met 
                


<210>  24
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  24

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Leu Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  25
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  25

Met Lys Phe Lys Asn Ile Val Lys Ser Ser Val Ala Thr Ser Ile Thr 
1               5                   10                  15      


Leu Ile Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr Gln Pro Thr Ser Asp Ser 
                85                  90                  95      


Ser Ile Asn Ser Gln Phe Tyr Trp Gly Ala Lys Tyr Asn Val Phe Val 
            100                 105                 110         


Ser Ser Glu Ser Lys Asp Ser Val Asn Ile Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ile Asn Gly Leu Thr Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Ser Asp Ser Leu Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Asn Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Ile Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Lys Asp Val Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Glu Asn Phe Trp Asn Asn Leu His Trp Ile 
        275                 280                 285             


Gly Tyr Asn Phe Lys Asn Gln Lys Arg Ala Thr His Thr Ser Ile Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Lys His Thr Val Lys Leu Val Ala Ser Gln Ser 
305                 310                 315                 320 


Ser Glu 
        


<210>  26
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  26

Met Lys Phe Lys Asn Ile Val Lys Ser Ser Val Ala Thr Ser Ile Thr 
1               5                   10                  15      


Leu Ile Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr Gln Pro Thr Ser Asp Ser 
                85                  90                  95      


Ser Ile Asn Ser Gln Phe Tyr Trp Gly Ala Lys Tyr Asn Val Phe Val 
            100                 105                 110         


Ser Ser Glu Ser Lys Asp Ser Val Asn Ile Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ile Asn Gly Leu Thr Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Ser Asp Ser Leu Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Asn Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Ile Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Lys Asp Val Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Glu Asn Phe Trp Asn Asn Leu His Trp Ile 
        275                 280                 285             


Gly Tyr Asn Ile Lys Asn Gln Lys Arg Ala Thr His Thr Ser Ile Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Lys His Thr Val Lys Leu Val Ala Ser Gln Ser 
305                 310                 315                 320 


Ser Glu 
        


<210>  27
<211>  322
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  wild-type LukF-PV amino acid sequence

<400>  27

Met Lys Ile Lys Asn Ile Val Lys Ser Ser Val Ala Thr Ser Ile Thr 
1               5                   10                  15      


Phe Ile Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr Gln Pro Thr Ser Asp Ser 
                85                  90                  95      


Ser Ile Asn Ser Gln Phe Tyr Trp Gly Ala Lys Tyr Asn Val Phe Val 
            100                 105                 110         


Ser Ser Glu Ser Lys Asp Ser Val Asn Ile Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ile Asn Gly Leu Thr Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Ile Asn His Lys Leu Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Ser Asp Ser Leu Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Asn Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Ile Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Lys Asp Val Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Gln Met Asp Arg Tyr Glu Asn Phe Trp Asn Asn Leu His Trp Ile 
        275                 280                 285             


Gly Tyr Asn Ile Lys Asn Gln Lys Arg Ala Thr His Thr Ser Ile Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Lys His Thr Val Lys Leu Val Ala Ser Gln Ser 
305                 310                 315                 320 


Ser Glu 
        


<210>  28
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panton-Valentine leukocidin chain S precursor amino acid sequence

<400>  28

Met Ile Phe Met Val Lys Lys Arg Leu Leu Ala Ala Thr Leu Ser Leu 
1               5                   10                  15      


Gly Ile Ile Thr Pro Ile Ala Thr Ser Phe His Glu Ser Lys Ala Asp 
            20                  25                  30          


Asn Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Val Lys Arg Thr 
        35                  40                  45              


Glu Asp Thr Ser Ser Asp Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Asn Ser Lys Thr Thr Tyr Tyr Asn Tyr Lys Asn 
                85                  90                  95      


Thr Asp His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Asp Ser Val Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Asn Ser Gly Pro Ser Thr Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Thr Ile Ser Tyr Asn Gln Gln Asn Tyr Ile Ser Glu 
                165                 170                 175     


Val Glu His Gln Asn Ser Lys Ser Val Gln Trp Gly Ile Lys Ala Asn 
            180                 185                 190         


Ser Phe Ile Thr Ser Leu Gly Lys Met Ser Gly His Asp Pro Asn Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro Tyr Ser Gln Asn Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Asn Glu Leu Pro Pro Leu Val His Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Thr Arg 
            260                 265                 270         


Arg Thr Thr His Tyr Gly Asn Ser Tyr Leu Glu Gly Ser Arg Ile His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly His Asn 
305                 310                 315 


<210>  29
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  29

Met Leu Lys Asn Lys Met Leu Ala Thr Thr Leu Ser Ile Ser Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Thr Pro Leu Phe Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Ala Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Ser Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Gly Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  30
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin S subunit amino acid sequence

<400>  30

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Lys Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Asn 
                85                  90                  95      


Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Val Thr Ala Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Ile His 
        275                 280                 285             


Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  31
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Panton-Valentine leukocidin subunit S amino acid sequence

<400>  31

Met Lys Leu Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val 
1               5                   10                  15      


Ser Leu Leu Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala 
            20                  25                  30          


Ala Asn Asp Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile 
        35                  40                  45              


Lys Arg Thr Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn 
    50                  55                  60                  


Ile Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu 
65                  70                  75                  80  


Ile Leu Lys Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn 
                85                  90                  95      


Tyr Lys Asn Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr 
            100                 105                 110         


Asn Ile Gly Leu Lys Thr Asn Asp Ser Asn Val Ser Leu Ile Asn Tyr 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly 
    130                 135                 140                 


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn 
145                 150                 155                 160 


Gly Ser Phe Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr 
                165                 170                 175     


Val Ser Glu Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val 
            180                 185                 190         


Lys Ala Asn Ser Phe Val Thr Ala Ser Gly Gln Lys Ser Ala Phe Asp 
        195                 200                 205             


Ser Asp Leu Phe Val Gly Tyr Lys Pro Asn Ser Lys Asp Pro Arg Asp 
    210                 215                 220                 


Tyr Phe Val Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe 
225                 230                 235                 240 


Asn Pro Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp 
                245                 250                 255     


Thr Ser Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His 
            260                 265                 270         


Ala Ile Lys Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His 
        275                 280                 285             


Arg Val His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu 
    290                 295                 300                 


Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315             


<210>  32
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C amino acid sequence

<400>  32

Met Leu Lys Asn Lys Ile Leu Ala Ala Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Pro Asn Ile Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  33
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin S subunit amino acid sequence

<400>  33

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Ile Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Asn 
                85                  90                  95      


Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Val Thr Ala Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro Asn Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Gly Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  34
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C amino acid sequence

<400>  34

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  35
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  35

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Glu Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  36
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin S subunit amino acid sequence

<400>  36

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Ala 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  37
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  37

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Ser 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  38
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  38

Met Lys Leu Met Leu Lys Asn Lys Ile Leu Thr Thr Thr Leu Ser Val 
1               5                   10                  15      


Ser Leu Leu Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala 
            20                  25                  30          


Ala Asn Asp Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile 
        35                  40                  45              


Lys Arg Thr Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn 
    50                  55                  60                  


Ile Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu 
65                  70                  75                  80  


Ile Leu Lys Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn 
                85                  90                  95      


Tyr Lys Lys Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr 
            100                 105                 110         


Asn Ile Gly Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly 
    130                 135                 140                 


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn 
145                 150                 155                 160 


Gly Ser Phe Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr 
                165                 170                 175     


Val Ser Glu Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val 
            180                 185                 190         


Lys Ala Asn Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp 
        195                 200                 205             


Ser Asp Leu Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp 
    210                 215                 220                 


Tyr Phe Val Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe 
225                 230                 235                 240 


Asn Pro Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp 
                245                 250                 255     


Thr Ser Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His 
            260                 265                 270         


Ala Ile Lys Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His 
        275                 280                 285             


Arg Val His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu 
    290                 295                 300                 


Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315             


<210>  39
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  39

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn His Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  40
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  40

Met Lys Ile Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val 
1               5                   10                  15      


Ser Leu Leu Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala 
            20                  25                  30          


Ala Asn Asp Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile 
        35                  40                  45              


Lys Arg Thr Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn 
    50                  55                  60                  


Ile Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu 
65                  70                  75                  80  


Ile Leu Lys Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn 
                85                  90                  95      


Tyr Lys Asn Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr 
            100                 105                 110         


Asn Ile Gly Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr 
        115                 120                 125             


Leu Pro Lys Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly 
    130                 135                 140                 


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn 
145                 150                 155                 160 


Gly Ser Phe Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr 
                165                 170                 175     


Val Ser Glu Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val 
            180                 185                 190         


Lys Ala Asn Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp 
        195                 200                 205             


Ser Asp Leu Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp 
    210                 215                 220                 


Tyr Phe Val Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe 
225                 230                 235                 240 


Asn Pro Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp 
                245                 250                 255     


Thr Ser Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His 
            260                 265                 270         


Ala Ile Lys Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His 
        275                 280                 285             


Arg Val His Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val Lys Tyr Glu 
    290                 295                 300                 


Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315             


<210>  41
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  41

Met Leu Lys Asn Lys Ile Leu Thr Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  42
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin S subunit amino acid sequence

<400>  42

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Thr Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  43
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  43

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Asn 
                85                  90                  95      


Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  44
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  44

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asn Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Ile Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Ser Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  45
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  45

Met Leu Lys Asn Lys Ile Leu Thr Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys 
                85                  90                  95      


Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Ile Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  46
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  S component of leucocodin R amino acid sequence

<400>  46

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Ser Lys Asn 
                85                  90                  95      


Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  47
<211>  315
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hlgC-like ORFamino acid sequence

<400>  47

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Gly Phe Val Lys Asp Lys Lys Tyr Asn Lys Val Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Asn 
                85                  90                  95      


Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
                165                 170                 175     


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
        195                 200                 205             


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
    210                 215                 220                 


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
            260                 265                 270         


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
        275                 280                 285             


Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
    290                 295                 300                 


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
305                 310                 315 


<210>  48
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin LukS component amino acid sequence

<400>  48

Ala Asn Asp Thr Glu Asp Ile Gly Lys Gly Ser Asp Ile Glu Ile Ile 
1               5                   10                  15      


Lys Arg Thr Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn 
            20                  25                  30          


Ile Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu 
        35                  40                  45              


Ile Leu Lys Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn 
    50                  55                  60                  


Tyr Lys Lys Thr Asn His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr 
65                  70                  75                  80  


Asn Ile Gly Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr 
                85                  90                  95      


Leu Pro Lys Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly 
            100                 105                 110         


Tyr Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn 
        115                 120                 125             


Gly Ser Phe Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr 
    130                 135                 140                 


Val Ser Glu Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val 
145                 150                 155                 160 


Lys Ala Asn Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp 
                165                 170                 175     


Ser Asp Leu Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp 
            180                 185                 190         


Tyr Phe Val Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe 
        195                 200                 205             


Asn Pro Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp 
    210                 215                 220                 


Thr Ser Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His 
225                 230                 235                 240 


Ala Ile Lys Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His 
                245                 250                 255     


Arg Val His Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu 
            260                 265                 270         


Val Asn Trp Lys Thr His Glu Ile Lys Glu Lys Gly Gln Asn 
        275                 280                 285     


<210>  49
<211>  305
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C amino acid sequence

<400>  49

Met Leu Lys Asn Lys Ile Leu Ala Thr Thr Leu Ser Val Ser Leu Leu 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Leu Leu Glu Asn Ala Lys Ala Ala Asn Asp 
            20                  25                  30          


Thr Glu Asp Ile Gly Lys Gly Asn Asp Val Glu Ile Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Lys Thr Ser Asn Lys Trp Gly Val Thr Gln Asn Ile Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Asn 
                85                  90                  95      


Thr Asn His Ile Lys Ser Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly 
            100                 105                 110         


Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
    130                 135                 140                 


Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln 
145                 150                 155                 160 


Gln Asn Tyr Val Ser Glu Val Glu Gln Gln Asn Ser Lys Ser Val Leu 
                165                 170                 175     


Trp Gly Val Lys Ala Asn Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser 
            180                 185                 190         


Ala Phe Asp Ser Asp Leu Phe Val Gly Tyr Lys Pro His Ser Lys Asp 
        195                 200                 205             


Pro Arg Asp Tyr Phe Val Pro Asp Ser Glu Leu Pro Pro Leu Val Gln 
    210                 215                 220                 


Ser Gly Phe Asn Pro Ser Phe Ile Ala Thr Val Ser His Glu Lys Gly 
225                 230                 235                 240 


Ser Ser Asp Thr Ser Glu Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp 
                245                 250                 255     


Val Thr His Ala Ile Lys Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu 
            260                 265                 270         


Asp Gly His Arg Val His Asn Ala Phe Lys Asn Arg Asn Tyr Thr Val 
        275                 280                 285             


Lys Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly Gln 
    290                 295                 300                 


Asn 
305 


<210>  50
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A amino acid sequence

<400>  50

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Val 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  51
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin S-subunit amino acid sequence

<400>  51

Met Lys Leu Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val 
1               5                   10                  15      


Gly Leu Ile Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn 
            20                  25                  30          


Thr Asn Ile Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr 
        35                  40                  45              


Glu Asp Val Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe 
    50                  55                  60                  


Asp Phe Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys 
65                  70                  75                  80  


Met Gln Gly Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly 
                85                  90                  95      


Ser Gly Tyr Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn 
            100                 105                 110         


Ile Gly Leu Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu 
        115                 120                 125             


Pro Lys Asn Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr 
    130                 135                 140                 


Asn Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly 
145                 150                 155                 160 


Ser Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val 
                165                 170                 175     


Ser Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys 
            180                 185                 190         


Ala Asn Glu Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg 
        195                 200                 205             


Tyr Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu 
    210                 215                 220                 


Tyr Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe 
225                 230                 235                 240 


Asn Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp 
                245                 250                 255     


Thr Ser Glu Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr 
            260                 265                 270         


Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn 
        275                 280                 285             


Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys 
    290                 295                 300                 


Thr His Glu Ile Lys Val Lys Gly His Asn 
305                 310                 


<210>  52
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin S-subunit amino acid sequence

<400>  52

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  53
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin LukE precursor amino acid sequence

<400>  53

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile His Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Met Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Ile Ser His Glu Lys Gly Thr Ser Glu Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  54
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LukNS amino acid sequence

<400>  54

Met Phe Lys Lys Gln Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  55
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin/Hemolysin toxin family protein amino acid sequence

<400>  55

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ala Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  56
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin E-subunit amino acid sequence

<400>  56

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Ser Thr Lys Asp Pro Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Ala 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Val 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  57
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin S-subunit amino acid sequence

<400>  57

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Arg Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  58
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Beta-channel forming cytolysin amino acid sequence

<400>  58

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Ala Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  59
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gamma-hemolysin component A amino acid sequence

<400>  59

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Ala Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  60
<211>  311
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin E-subunit amino acid sequence

<400>  60

Met Phe Lys Lys Lys Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Gly Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn 
        115                 120                 125             


Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly 
    130                 135                 140                 


Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn 
145                 150                 155                 160 


Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val 
                165                 170                 175     


Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu 
            180                 185                 190         


Phe Val Thr Pro Asp Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe 
        195                 200                 205             


Val Gln Ser Pro Asn Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Ala 
    210                 215                 220                 


Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
225                 230                 235                 240 


Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
                245                 250                 255     


Phe Glu Ile Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu 
            260                 265                 270         


Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val 
        275                 280                 285             


Asn Arg Asn Phe Val Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu 
    290                 295                 300                 


Ile Lys Val Lys Gly His Asn 
305                 310     


<210>  61
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin S-subunit amino acid sequence

<400>  61

Met Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Leu Lys Met Gln 
1               5                   10                  15      


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Tyr Asn Tyr Lys Lys Thr Asn 
            20                  25                  30          


His Val Lys Ala Met Arg Trp Pro Phe Gln Tyr Asn Ile Gly Leu Lys 
        35                  40                  45              


Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
    50                  55                  60                  


Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile Gly Gly 
65                  70                  75                  80  


Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe Asn Tyr 
                85                  90                  95      


Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu Val Glu 
            100                 105                 110         


Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn Ser Phe 
        115                 120                 125             


Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu Phe Val 
    130                 135                 140                 


Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val Pro Asp 
145                 150                 155                 160 


Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile 
                165                 170                 175     


Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu 
            180                 185                 190         


Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys Arg Ser 
        195                 200                 205             


Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His Asn Ala 
    210                 215                 220                 


Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp Lys Thr 
225                 230                 235                 240 


His Glu Ile Lys Val Lys Gly Gln Asn 
                245                 


<210>  62
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin S-subunit amino acid sequence

<400>  62

Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile Ala Pro Leu Ala Ser 
1               5                   10                  15      


Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile Glu Asn Ile Gly Asp 
            20                  25                  30          


Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val Ser Ser Lys Lys Trp 
        35                  40                  45              


Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr 
    50                  55                  60                  


Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe Ile Asn Ser Arg 
65                  70                  75                  80  


Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu Leu Thr Lys Arg 
                85                  90                  95      


Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Thr Lys Asp Pro 
            100                 105                 110         


Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Glu Thr Thr 
        115                 120                 125             


Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
    130                 135                 140                 


Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
145                 150                 155                 160 


Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp Lys Gln Asn Ser 
                165                 170                 175     


Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu Phe Val Thr Pro Asp 
            180                 185                 190         


Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe Val Gln Ser Pro Asn 
        195                 200                 205             


Gly Pro Thr Gly Ser Ala Arg Glu Tyr Phe Ala Pro Asp Asn Gln Leu 
    210                 215                 220                 


Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu 
225                 230                 235                 240 


Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu Ile Ser Tyr 
                245                 250                 255     


Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe Pro Arg Thr Gly 
            260                 265                 270         


Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn Arg Asn Phe Val 
        275                 280                 285             


Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly 
    290                 295                 300                 


His Asn 
305     


<210>  63
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin E-subunit amino acid sequence

<400>  63

Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile Ala Pro Leu Ala Ser 
1               5                   10                  15      


Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile Glu Asn Ile Gly Asp 
            20                  25                  30          


Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val Ser Ser Lys Lys Trp 
        35                  40                  45              


Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr 
    50                  55                  60                  


Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe Ile Asn Ser Arg 
65                  70                  75                  80  


Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu Leu Thr Lys Arg 
                85                  90                  95      


Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Ser Thr Lys Asp Pro 
            100                 105                 110         


Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Glu Thr Thr 
        115                 120                 125             


Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
    130                 135                 140                 


Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
145                 150                 155                 160 


Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp Lys Gln Asn Ser 
                165                 170                 175     


Lys Ser Val Lys Trp Gly Val Lys Ala Asn Ala Phe Val Thr Pro Asp 
            180                 185                 190         


Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe Val Gln Ser Pro Asn 
        195                 200                 205             


Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Val Pro Asp Asn Gln Leu 
    210                 215                 220                 


Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu 
225                 230                 235                 240 


Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu Ile Ser Tyr 
                245                 250                 255     


Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe Pro Arg Thr Gly 
            260                 265                 270         


Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn Arg Asn Phe Val 
        275                 280                 285             


Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly 
    290                 295                 300                 


His Asn 
305     


<210>  64
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gamma-hemolysin component A amino acid sequence

<400>  64

Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile Ala Pro Leu Ala Ser 
1               5                   10                  15      


Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile Glu Asn Ile Gly Asp 
            20                  25                  30          


Gly Ala Glu Val Ile Lys Arg Met Glu Asp Val Ser Ser Lys Lys Trp 
        35                  40                  45              


Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr 
    50                  55                  60                  


Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe Ile Asn Ser Arg 
65                  70                  75                  80  


Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu Leu Thr Lys Arg 
                85                  90                  95      


Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Thr Lys Asp Pro 
            100                 105                 110         


Asn Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Glu Thr Thr 
        115                 120                 125             


Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
    130                 135                 140                 


Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
145                 150                 155                 160 


Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp Lys Gln Asn Ser 
                165                 170                 175     


Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu Phe Val Thr Pro Asp 
            180                 185                 190         


Gly Lys Lys Ser Ala His Asp Arg Tyr Leu Phe Val Gln Ser Pro Asn 
        195                 200                 205             


Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Ala Pro Asp Asn Gln Leu 
    210                 215                 220                 


Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu 
225                 230                 235                 240 


Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu Ile Ser Tyr 
                245                 250                 255     


Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe Pro Arg Thr Gly 
            260                 265                 270         


Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn Arg Asn Phe Val 
        275                 280                 285             


Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly 
    290                 295                 300                 


His Asn 
305     


<210>  65
<211>  306
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gamma-hemolysin component A amino acid sequence

<400>  65

Met Leu Ala Ala Thr Leu Ser Val Gly Leu Ile Ala Pro Leu Ala Ser 
1               5                   10                  15      


Pro Ile His Glu Ser Arg Ala Asn Thr Asn Ile Glu Asn Ile Gly Asp 
            20                  25                  30          


Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val Ser Ser Lys Lys Trp 
        35                  40                  45              


Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val Lys Asp Lys Lys Tyr 
    50                  55                  60                  


Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly Phe Ile Asn Ser Arg 
65                  70                  75                  80  


Thr Ser Phe Ser Asp Val Lys Gly Ser Gly Tyr Glu Leu Thr Lys Arg 
                85                  90                  95      


Met Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu Ser Thr Lys Asp Pro 
            100                 105                 110         


Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Glu Thr Thr 
        115                 120                 125             


Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
    130                 135                 140                 


Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
145                 150                 155                 160 


Ser Tyr Thr Gln Lys Ser Tyr Val Ser Glu Val Asp Lys Gln Asn Ser 
                165                 170                 175     


Lys Ser Val Lys Trp Gly Val Lys Ala Asn Glu Phe Val Thr Pro Asp 
            180                 185                 190         


Gly Lys Lys Ser Ala Gln Asp Arg Tyr Leu Phe Val Gln Ser Pro Asn 
        195                 200                 205             


Gly Pro Ser Gly Ser Ala Arg Glu Tyr Phe Ala Pro Asp Asn Gln Leu 
    210                 215                 220                 


Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu 
225                 230                 235                 240 


Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu Phe Glu Ile Ser Tyr 
                245                 250                 255     


Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Leu Phe Pro Arg Thr Gly 
            260                 265                 270         


Ile Tyr Ala Glu Arg Lys His Asn Ala Phe Val Asn Arg Asn Phe Val 
        275                 280                 285             


Val Arg Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val Lys Gly 
    290                 295                 300                 


His Asn 
305     


<210>  66
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin chain lukM precursor amino acid sequence

<400>  66

Met Phe Lys Arg Lys Leu Leu Val Thr Thr Leu Ser Leu Gly Leu Ile 
1               5                   10                  15      


Val Pro Ile Ala Thr Pro Phe Gln Gly Ser Lys Ala Thr Thr Asn Ala 
            20                  25                  30          


Glu Asp Ile Gly Asp Asp Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Arg Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Ile Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Thr Phe Asn Asp Val Lys Gln Asn Arg Ala 
                85                  90                  95      


Asn Lys Arg Met Val Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Ser 
            100                 105                 110         


Lys Asp Gln Asn Thr Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile 
        115                 120                 125             


Glu Thr Val Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Lys 
    130                 135                 140                 


Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser 
145                 150                 155                 160 


Lys Ser Ile Lys Tyr Ser Gln Lys Ser Tyr Val Ser Glu Val Glu Gln 
                165                 170                 175     


Gln Ser Ser Lys Thr Ile Lys Trp Gly Val Lys Ala Asn Ser Phe Val 
            180                 185                 190         


Ile Ala Gly His Arg Trp Ser Ala Tyr Asp Glu Leu Leu Phe Ile Arg 
        195                 200                 205             


Asn Thr Thr Arg Gly Pro Asn Ala Arg Asp Tyr Phe Val Asp Asp Asn 
    210                 215                 220                 


Glu Leu Pro Pro Leu Ile Thr Ser Gly Phe Asn Pro Ser Phe Ile Ala 
225                 230                 235                 240 


Thr Val Ser His Glu Lys Asp Ser Gly Asp Thr Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Val Thr Tyr Ala Thr Tyr Leu Pro Lys 
            260                 265                 270         


Gln Gly Leu Tyr Pro Glu Arg Lys His Asn Glu Phe Val Asn Arg Asn 
        275                 280                 285             


Phe Val Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Ile Lys Val 
    290                 295                 300                 


Lys Gly His Asn 
305             


<210>  67
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin chain lukM precursor amino acid sequence

<400>  67

Met Phe Lys Arg Lys Leu Leu Val Thr Thr Leu Ser Leu Gly Leu Ile 
1               5                   10                  15      


Val Pro Ile Ala Thr Pro Phe Gln Gly Ser Lys Ala Thr Thr Asn Ala 
            20                  25                  30          


Glu Asp Ile Gly Asp Asp Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Arg Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Ile Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Thr Phe Asn Asp Val Lys Gln Asn Arg Ala 
                85                  90                  95      


Asn Lys Arg Met Val Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Ser 
            100                 105                 110         


Lys Asp Gln Asn Thr Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile 
        115                 120                 125             


Glu Thr Val Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Lys 
    130                 135                 140                 


Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser 
145                 150                 155                 160 


Lys Ser Ile Lys Tyr Ser Gln Lys Ser Tyr Val Ser Glu Val Glu Gln 
                165                 170                 175     


Gln Ser Ser Lys Thr Ile Lys Trp Gly Val Lys Ala Asn Ser Phe Val 
            180                 185                 190         


Ile Ala Gly His Arg Trp Ser Ala Tyr Asp Glu Leu Leu Phe Ile Arg 
        195                 200                 205             


Asn Thr Thr Arg Gly Pro Asn Ala Arg Asp Tyr Phe Val Asp Asp Asn 
    210                 215                 220                 


Glu Leu Pro Pro Leu Ile Thr Ser Gly Phe Asn Pro Ser Phe Ile Ala 
225                 230                 235                 240 


Thr Val Ser His Glu Lys Asp Ser Gly Asp Thr Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Val Thr Tyr Ala Thr Tyr Leu Pro Lys 
            260                 265                 270         


Leu Gly Leu Tyr Pro Glu Arg Lys His Asn Glu Phe Val Asn Arg Asn 
        275                 280                 285             


Phe Val Val Lys Tyr Glu Val Asn Trp Lys Thr Tyr Glu Ile Lys Val 
    290                 295                 300                 


Lys Gly His Asn 
305             


<210>  68
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LukM precursor amino acid sequence

<400>  68

Met Phe Lys Arg Lys Leu Leu Val Thr Thr Leu Ser Leu Gly Leu Ile 
1               5                   10                  15      


Val Pro Ile Ala Thr Pro Phe Gln Gly Ser Lys Ala Thr Thr Asn Ala 
            20                  25                  30          


Glu Asp Ile Gly Asp Asp Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Arg Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Ile Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Thr Phe Asn Asp Val Lys Gln Asn Arg Ala 
                85                  90                  95      


Asn Lys Arg Met Val Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Ser 
            100                 105                 110         


Lys Asp Gln Asn Thr Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile 
        115                 120                 125             


Glu Thr Val Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Lys 
    130                 135                 140                 


Phe Gln Ser Val Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser 
145                 150                 155                 160 


Lys Ser Ile Lys Tyr Ser Gln Lys Ser Tyr Val Ser Glu Val Glu Gln 
                165                 170                 175     


Gln Ser Ser Lys Thr Ile Lys Trp Gly Val Lys Ala Asn Ser Phe Val 
            180                 185                 190         


Ile Ala Gly His Arg Trp Ser Ala Tyr Asp Glu Leu Leu Phe Ile Arg 
        195                 200                 205             


Asn Thr Thr Arg Gly Pro Asn Ala Arg Asp Tyr Phe Val Asp Asp Asn 
    210                 215                 220                 


Glu Leu Pro Pro Leu Ile Thr Ser Gly Phe Asn Pro Ser Phe Ile Ala 
225                 230                 235                 240 


Thr Val Ser His Glu Lys Asp Ser Gly Asp Thr Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Val Thr Tyr Ala Thr Tyr Leu Pro Lys 
            260                 265                 270         


Leu Gly Leu Tyr Pro Glu Arg Lys His Asn Glu Phe Val Asn Arg Asn 
        275                 280                 285             


Phe Val Val Lys Tyr Glu Val Asn Trp Lys Thr Tyr Glu Ile Lys Val 
    290                 295                 300                 


Lys Gly His Asn 
305             


<210>  69
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  69

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Pro Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Thr Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Ile Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  70
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  70

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Phe Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  71
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-channel forming cytolysin amino acid sequence

<400>  71

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Thr Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Lys Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  72
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma hemolysin amino acid sequence

<400>  72

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Lys Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  73
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  73

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Lys Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Thr Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  74
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  74

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Lys Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  75
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  75

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Ala Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  76
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin chain II precursor amino acid sequence

<400>  76

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  77
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-channel forming cytolysin amino acid sequence

<400>  77

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  78
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  beta-channel forming cytolysin amino acid sequence

<400>  78

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Leu Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  79
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  preLukM amino acid sequence

<400>  79

Met Phe Asn Arg Lys Leu Leu Val Thr Thr Leu Ser Leu Gly Leu Ile 
1               5                   10                  15      


Val Pro Ile Ala Thr Pro Phe Gln Gly Ser Lys Ala Thr Thr Asn Ala 
            20                  25                  30          


Glu Asp Ile Gly Asp Asp Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Arg Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Ile Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Thr Phe Asn Asp Val Lys Gln Asn Arg Ala 
                85                  90                  95      


Asn Lys Arg Met Val Trp Pro Phe Gln Tyr Asn Ile Gly Leu Thr Ser 
            100                 105                 110         


Lys Asp Gln Asn Thr Ser Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile 
        115                 120                 125             


Glu Thr Val Asp Val Gly Gln Thr Leu Gly Tyr Asn Ile Gly Gly Lys 
    130                 135                 140                 


Phe Gln Ser Val Pro Ser Ile Gly Gly Asn Gly Ser Phe Asn Tyr Ser 
145                 150                 155                 160 


Lys Ser Ile Lys Tyr Ser Gln Lys Ser Tyr Val Ser Glu Val Glu Gln 
                165                 170                 175     


Gln Ser Ser Lys Thr Ile Lys Trp Gly Val Lys Ala Asn Ser Phe Val 
            180                 185                 190         


Ile Ala Gly His Arg Trp Ser Ala Tyr Asp Glu Leu Leu Phe Ile Arg 
        195                 200                 205             


Asn Thr Thr Arg Gly Pro Asn Ala Arg Asp Tyr Phe Val Asp Asp Asn 
    210                 215                 220                 


Glu Leu Pro Pro Leu Ile Thr Ser Gly Phe Asn Pro Ser Phe Ile Ala 
225                 230                 235                 240 


Thr Val Ser His Glu Lys Asp Ser Gly Asp Thr Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Val Thr Tyr Ala Thr Tyr Leu Pro Lys 
            260                 265                 270         


Leu Gly Leu Tyr Pro Glu Arg Lys His Asn Glu Phe Val Asn Arg Asn 
        275                 280                 285             


Leu Val Val Lys Tyr Glu Val Asn Trp Lys Thr Ser Glu Leu Lys Val 
    290                 295                 300                 


Arg Gly His Asn 
305             


<210>  80
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  80

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Met 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Thr Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Leu Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  81
<211>  309
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin-S subunit amino acid sequence

<400>  81

Met Ile Lys Asn Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys 
            20                  25                  30          


Ile Glu Asp Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp 
        35                  40                  45              


Ile Thr Ser Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro 
                85                  90                  95      


Tyr Ile Lys Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys 
            100                 105                 110         


Thr Lys Asp Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys 
        115                 120                 125             


Ile Asp Ser Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly 
    130                 135                 140                 


Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr 
145                 150                 155                 160 


Ser Lys Thr Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu 
                165                 170                 175     


Ser Gln Asn Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe 
            180                 185                 190         


Val Thr Pro Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala 
        195                 200                 205             


Gln Asp Pro Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn 
    210                 215                 220                 


Gln Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr 
225                 230                 235                 240 


Thr Leu Ser His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile 
                245                 250                 255     


Thr Tyr Gly Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His 
            260                 265                 270         


Arg Phe Ala Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val 
        275                 280                 285             


Thr Val Lys Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys 
    290                 295                 300                 


Ser Ile Thr Pro Lys 
305                 


<210>  82
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  hlgA-like ORF amino acid sequence

<400>  82

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Gly Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Lys Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg Pro Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  83
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  83

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Arg Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Arg Gly Lys Gly Asp Lys Ser Asp Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  84
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  84

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Lys Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Arg Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Lys Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  85
<211>  321
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component A precursor amino acid sequence

<400>  85

Met Asn Leu Lys Leu Asn Arg Lys Lys Val Ile Ser Met Ile Lys Asn 
1               5                   10                  15      


Lys Ile Leu Thr Ala Thr Leu Ala Val Gly Leu Ile Ala Pro Leu Ala 
            20                  25                  30          


Asn Pro Phe Ile Glu Ile Ser Arg Ala Glu Asn Lys Ile Glu Asp Ile 
        35                  40                  45              


Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser Lys 
    50                  55                  60                  


Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp Lys 
65                  70                  75                  80  


Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile Ser 
                85                  90                  95      


Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys Arg 
            100                 105                 110         


Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp Ser 
        115                 120                 125             


Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser Ala 
    130                 135                 140                 


Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln Ser 
145                 150                 155                 160 


Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr Ile 
                165                 170                 175     


Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn Ser 
            180                 185                 190         


Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro Asn 
        195                 200                 205             


Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Gln Thr 
    210                 215                 220                 


Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro Pro 
225                 230                 235                 240 


Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser His 
                245                 250                 255     


Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly Arg 
            260                 265                 270         


Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala Val 
        275                 280                 285             


Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys Tyr 
    290                 295                 300                 


Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr Pro 
305                 310                 315                 320 


Lys 
    


<210>  86
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synergohymenotropic toxin amino acid sequenceSynergohymenotropic 
       toxin amino acid sequence

<400>  86

Met Val Lys Asn Lys Leu Leu Ala Ala Thr Leu Ser Ile Ser Leu Ile 
1               5                   10                  15      


Leu Pro Leu Ile Thr Pro Tyr Ser Glu Glu Ala Lys Ala Ala Asn Thr 
            20                  25                  30          


Ile Glu Glu Ile Gly Glu Gly Ala Gln Ile Ile Lys Arg Thr Glu Asp 
        35                  40                  45              


Val Ser Ser Arg Lys Trp Gly Val Thr Gln Asn Ile Gln Phe Asp Phe 
    50                  55                  60                  


Val Lys Asp Pro Lys Tyr Asn Lys Asp Ala Leu Ile Ile Lys Met Gln 
65                  70                  75                  80  


Gly Phe Ile Lys Ser Arg Thr Ser Phe Thr Asp Val Lys Gly Lys Gly 
                85                  90                  95      


Tyr Glu Ser Thr Lys Arg Ile Leu Trp Pro Phe Gln Tyr Asn Ile Ala 
            100                 105                 110         


Leu Lys Thr Asn Asp Pro Asn Val Phe Leu Ile Asn Tyr Leu Pro Lys 
        115                 120                 125             


Asn Lys Ile Glu Ser Ile Asp Val Ser Gln Thr Leu Gly Tyr Asn Val 
    130                 135                 140                 


Gly Gly Asn Phe Gln Ser Ala Pro Leu Leu Gly Gly Lys Gly Glu Phe 
145                 150                 155                 160 


Asn Tyr Ser Lys Lys Ile Ser Tyr Thr Gln Lys Asn Tyr Ile Ser Glu 
                165                 170                 175     


Val Ala Gln Gln Asn Ser Lys Asn Ile Arg Trp Glu Val Lys Ala Asn 
            180                 185                 190         


Ser Phe Asn Thr Glu Asn Gly Gln Val Ser Ala Tyr Asp Arg His Leu 
        195                 200                 205             


Phe Val Arg Ser Pro Ile Gly Pro Asn Ala Arg Asp Phe Phe Val Pro 
    210                 215                 220                 


Asn Asp Glu Leu Pro Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe 
225                 230                 235                 240 


Ile Ala Thr Val Ser His Glu Lys Asp Lys Gly Asp Thr Ser Glu Phe 
                245                 250                 255     


Glu Ile Ala Tyr Gly Arg Asn Leu Asp Ile Thr Tyr Ala Thr Phe Phe 
            260                 265                 270         


Pro Arg Thr Gly Ile Phe Ala Glu Arg Arg His Asn Ala Leu Met Asn 
        275                 280                 285             


Arg Asn Leu Val Thr Lys Tyr Glu Val Asn Trp Lys Thr His Glu Ile 
    290                 295                 300                 


Lys Val Lys Gly His Asn 
305                 310 


<210>  87
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin LukEamino acid sequence

<400>  87

Met Phe Lys Lys Lys Met Leu Ala Ala Ser Leu Ser Val Gly Leu Ile 
1               5                   10                  15      


Ala Pro Leu Ala Ser Pro Ile Gln Glu Ser Arg Ala Asn Thr Asn Ile 
            20                  25                  30          


Glu Asn Ile Gly Asp Gly Ala Glu Val Ile Lys Arg Thr Glu Asp Val 
        35                  40                  45              


Ser Ser Lys Lys Trp Gly Val Thr Gln Asn Val Gln Phe Asp Phe Val 
    50                  55                  60                  


Lys Asp Lys Lys Tyr Asn Lys Asp Ala Leu Ile Val Lys Met Gln Gly 
65                  70                  75                  80  


Phe Ile Asn Ser Arg Thr Ser Phe Ser Asp Val Lys Gly Arg Gly Tyr 
                85                  90                  95      


Glu Leu Thr Lys Arg Leu Ile Trp Pro Phe Gln Tyr Asn Ile Gly Leu 
            100                 105                 110         


Thr Thr Lys Asp Pro Asn Val Ser Leu Ile Asn Ser Ile Thr Leu Pro 
        115                 120                 125             


Lys Thr Lys Ile Glu Thr Thr Asp Val Gly Gln Thr Leu Gly Tyr Asn 
    130                 135                 140                 


Ile Gly Gly Asn Phe Gln Ser Ala Pro Ser Ile Gly Gly Asn Gly Ser 
145                 150                 155                 160 


Phe Asn Tyr Ser Lys Thr Ile Ser Tyr Thr Gln Lys Ser Tyr Val Ser 
                165                 170                 175     


Glu Val Asp Lys Gln Asn Ser Lys Ser Val Lys Trp Gly Val Lys Ala 
            180                 185                 190         


Asn Lys Phe Val Thr Pro Asp Gly Lys Lys Phe Ala His Asp Arg Tyr 
        195                 200                 205             


Leu Phe Val Gln Ser Pro Asn Gly Pro Thr Gly Ser Ala Arg Glu Tyr 
    210                 215                 220                 


Phe Ala Pro Asp Asn Gln Leu Pro Pro Leu Val Gln Ser Gly Phe Asn 
225                 230                 235                 240 


Pro Ser Phe Ile Thr Thr Leu Ser His Glu Lys Gly Ser Lys Leu Ile 
                245                 250                 255     


Arg Val Asn Leu Lys Phe Ser Tyr Gly Arg Asn Leu Asp Ile Thr Tyr 
            260                 265                 270         


Ala Thr Leu Phe Pro Arg Thr Gly Ile Tyr Ala Glu Arg Lys His Asn 
        275                 280                 285             


Ala Phe Val Asn Arg Asn Phe Val Val Arg Tyr Lys Val Asn Trp Lys 
    290                 295                 300                 


Thr His Glu Ile Lys Val Lys Gly His Asn 
305                 310                 


<210>  88
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Chain B, crystal structure of octameric pore form of 
       gamma-hemolysin amino acid sequence

<400>  88

Met Gly His His His His His His Ala Met Glu Asn Lys Ile Glu Asp 
1               5                   10                  15      


Ile Gly Gln Gly Ala Glu Ile Ile Lys Arg Thr Gln Asp Ile Thr Ser 
            20                  25                  30          


Lys Arg Leu Ala Ile Thr Gln Asn Ile Gln Phe Asp Phe Val Lys Asp 
        35                  40                  45              


Lys Lys Tyr Asn Lys Asp Ala Leu Val Val Lys Met Gln Gly Phe Ile 
    50                  55                  60                  


Ser Ser Arg Thr Thr Tyr Ser Asp Leu Lys Lys Tyr Pro Tyr Ile Lys 
65                  70                  75                  80  


Arg Met Ile Trp Pro Phe Gln Tyr Asn Ile Ser Leu Lys Thr Lys Asp 
                85                  90                  95      


Ser Asn Val Asp Leu Ile Asn Tyr Leu Pro Lys Asn Lys Ile Asp Ser 
            100                 105                 110         


Ala Asp Val Ser Gln Lys Leu Gly Tyr Asn Ile Gly Gly Asn Phe Gln 
        115                 120                 125             


Ser Ala Pro Ser Ile Gly Gly Ser Gly Ser Phe Asn Tyr Ser Lys Thr 
    130                 135                 140                 


Ile Ser Tyr Asn Gln Lys Asn Tyr Val Thr Glu Val Glu Ser Gln Asn 
145                 150                 155                 160 


Ser Lys Gly Val Lys Trp Gly Val Lys Ala Asn Ser Phe Val Thr Pro 
                165                 170                 175     


Asn Gly Gln Val Ser Ala Tyr Asp Gln Tyr Leu Phe Ala Gln Asp Pro 
            180                 185                 190         


Thr Gly Pro Ala Ala Arg Asp Tyr Phe Val Pro Asp Asn Gln Leu Pro 
        195                 200                 205             


Pro Leu Ile Gln Ser Gly Phe Asn Pro Ser Phe Ile Thr Thr Leu Ser 
    210                 215                 220                 


His Glu Arg Gly Lys Gly Asp Lys Ser Glu Phe Glu Ile Thr Tyr Gly 
225                 230                 235                 240 


Arg Asn Met Asp Ala Thr Tyr Ala Tyr Val Thr Arg His Arg Leu Ala 
                245                 250                 255     


Val Asp Arg Lys His Asp Ala Phe Lys Asn Arg Asn Val Thr Val Lys 
            260                 265                 270         


Tyr Glu Val Asn Trp Lys Thr His Glu Val Lys Ile Lys Ser Ile Thr 
        275                 280                 285             


Pro Lys 
    290 


<210>  89
<211>  203
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C amino acid sequence

<400>  89

Leu Lys Thr Asn Asp Lys Tyr Val Ser Leu Ile Asn Tyr Leu Pro Lys 
1               5                   10                  15      


Asn Lys Ile Glu Ser Thr Asn Val Ser Gln Thr Leu Gly Tyr Asn Ile 
            20                  25                  30          


Gly Gly Asn Phe Gln Ser Ala Pro Ser Leu Gly Gly Asn Gly Ser Phe 
        35                  40                  45              


Asn Tyr Ser Lys Ser Ile Ser Tyr Thr Gln Gln Asn Tyr Val Ser Glu 
    50                  55                  60                  


Val Glu Gln Gln Asn Ser Lys Ser Val Leu Trp Gly Val Lys Ala Asn 
65                  70                  75                  80  


Ser Phe Ala Thr Glu Ser Gly Gln Lys Ser Ala Phe Asp Ser Asp Leu 
                85                  90                  95      


Phe Val Gly Tyr Lys Pro His Ser Lys Asp Pro Arg Asp Tyr Phe Val 
            100                 105                 110         


Pro Asp Ser Glu Leu Pro Pro Leu Val Gln Ser Gly Phe Asn Pro Ser 
        115                 120                 125             


Phe Ile Ala Thr Val Ser His Glu Lys Gly Ser Ser Asp Thr Ser Glu 
    130                 135                 140                 


Phe Glu Ile Thr Tyr Gly Arg Asn Met Asp Val Thr His Ala Ile Lys 
145                 150                 155                 160 


Arg Ser Thr His Tyr Gly Asn Ser Tyr Leu Asp Gly His Arg Val His 
                165                 170                 175     


Asn Ala Phe Val Asn Arg Asn Tyr Thr Val Lys Tyr Glu Val Asn Trp 
            180                 185                 190         


Lys Thr His Glu Ile Lys Val Lys Gly Gln Asn 
        195                 200             


<210>  90
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leucocidin F amino acid sequence

<400>  90

Met Lys Lys Ile Val Lys Ser Arg Glu Val Thr Ser Ile Ala Leu Leu 
1               5                   10                  15      


Leu Leu Ser Asn Thr Leu Asp Ala Ala Gln His Ile Thr Pro Val Ser 
            20                  25                  30          


Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr Ala Thr 
        35                  40                  45              


Ser Asp Ser Asp Lys Leu Lys Ile Ser Gln Ile Leu Thr Phe Asn Phe 
    50                  55                  60                  


Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Ile Leu Lys Ala Ala 
65                  70                  75                  80  


Gly Asn Ile Tyr Ser Gly Tyr Thr Lys Pro Asn Pro Lys Asp Thr Ile 
                85                  90                  95      


Ser Ser Gln Phe Tyr Trp Gly Ser Lys Tyr Asn Ile Ser Ile Asn Ser 
            100                 105                 110         


Asp Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys Asn Gln 
        115                 120                 125             


Asn Glu Glu Phe Gln Val Gln Gln Thr Val Gly Tyr Ser Tyr Gly Gly 
    130                 135                 140                 


Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Gly Asn Gly Ser Lys 
145                 150                 155                 160 


Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr Ser 
                165                 170                 175     


Leu Asp Lys Arg Thr Asn Phe Lys Lys Ile Gly Trp Asp Val Glu Ala 
            180                 185                 190         


His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Tyr 
        195                 200                 205             


His Ser Thr Tyr Gly Asn Glu Met Phe Leu Gly Ser Arg Gln Ser Asn 
    210                 215                 220                 


Leu Asn Ala Gly Gln Asn Phe Leu Glu Tyr His Lys Met Pro Val Leu 
225                 230                 235                 240 


Ser Arg Gly Asn Phe Asn Pro Glu Phe Ile Gly Val Leu Ser Arg Lys 
                245                 250                 255     


Gln Asn Ala Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln Ser Glu 
            260                 265                 270         


Met Asp Arg Tyr Thr Asn Phe Trp Ile Asn Phe Asn Trp Ile Gly Asn 
        275                 280                 285             


Asn Tyr Lys Asp His Ile Arg Ala Thr His Thr Ser Ile Tyr Glu Val 
    290                 295                 300                 


Asp Trp Glu Asn His Thr Val Lys Leu Ile Asp Thr Gln Ser Lys Glu 
305                 310                 315                 320 


Lys Asn Pro Met Ser 
                325 


<210>  91
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  91

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Leu Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  92
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  92

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Ala Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Ser Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  93
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin/Hemolysin toxin family protein amino acid sequence

<400>  93

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Thr Ser Ile Ala 
1               5                   10                  15      


Leu Ile Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Tyr Phe Tyr Trp Gly Ala Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Thr Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Glu Ala Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Tyr Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn His Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp His Asn His Thr Val Lys Leu Ile Asp Thr Asn Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  94
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin, LukD amino acid sequence

<400>  94

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Thr Ser Ile Ala 
1               5                   10                  15      


Leu Leu Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  95
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin, LukD amino acid sequence

<400>  95

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Thr Ser Ile Ala 
1               5                   10                  15      


Leu Leu Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Val Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asp Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  96
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin, LukD amino acid sequence

<400>  96

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  97
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin amino acid sequence

<400>  97

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Val 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  98
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  98

Met Lys Met Lys Lys Leu Ile Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  99
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  99

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Arg Asp 
                85                  90                  95      


Tyr Asp Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Ser Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  100
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin D subunit amino acid sequence

<400>  100

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Arg Asp 
                85                  90                  95      


Tyr Asp Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  101
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin D subunit amino acid sequence

<400>  101

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Asn Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Arg Asp 
                85                  90                  95      


Tyr Asp Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  102
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  102

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val His Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Ile 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  103
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin LukD amino acid sequence

<400>  103

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Ser Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Val 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  104
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin LukD amino acid sequence

<400>  104

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Phe Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Leu His Trp Val 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn His Thr Val Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  105
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin/hemolysin toxin family protein amino acid sequence

<400>  105

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Thr Ser Ile Ala 
1               5                   10                  15      


Leu Ile Met Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Tyr Phe Tyr Trp Gly Ala Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Asn Gly Leu Ser Gly Gly Leu Asn Gly Ser 
145                 150                 155                 160 


Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg Thr 
                165                 170                 175     


Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val Glu 
            180                 185                 190         


Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser 
        195                 200                 205             


Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln Ser 
    210                 215                 220                 


Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro Leu 
225                 230                 235                 240 


Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser His 
                245                 250                 255     


Lys Gln Asn Glu Ala Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln Arg 
            260                 265                 270         


Glu Met Asp Arg Tyr Thr Asn Tyr Trp Asn Arg Leu His Trp Ile Gly 
        275                 280                 285             


Asn Asn His Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr Glu 
    290                 295                 300                 


Val Asp Trp His Asn His Thr Val Lys Leu Ile Asp Thr Asn Ser Lys 
305                 310                 315                 320 


Glu Thr Asn Pro Gly Val 
                325     


<210>  106
<211>  327
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukotoxin, LukD amino acid sequence

<400>  106

Met Lys Ile Glu Lys Leu Gly Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln Asn Ile Thr Pro 
            20                  25                  30          


Lys Arg Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Phe Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Asn Ser Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Asp Lys 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Ile Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Leu Phe Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln Trp Asn Arg Ser His Trp Val 
        275                 280                 285             


Gly Asn Asn Tyr Lys Asn Gln Asn Thr Val Thr Phe Thr Ser Thr Tyr 
    290                 295                 300                 


Glu Val Asp Trp Gln Asn Ile Leu Leu Lys Leu Ile Gly Thr Asp Ser 
305                 310                 315                 320 


Lys Glu Thr Asn Pro Gly Val 
                325         


<210>  107
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Gamma-hemolysin component B amino acid sequence

<400>  107

Met Lys Ile Ser Lys Val Ile Lys Ala Ala Thr Ala Thr Ser Val Ala 
1               5                   10                  15      


Leu Met Leu Phe Ser Asn Pro Val Tyr Ala Ala Asn Gln Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Leu Asn Ile Ser Gln Leu Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Ser Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Ile Tyr Ser Ser Phe Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ala Glu Ser Lys Gly Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Ser Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Lys Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Glu Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Lys His Thr Asp Asn Lys Thr Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Ala Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Asp Leu Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Lys Leu Asn Ala Gly Gln Asn Phe Leu Pro Thr Ser Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Lys Pro Asn Gly Ala Lys Thr Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Glu Tyr Thr Asn Tyr Trp Asn Gly Phe His Trp Met 
        275                 280                 285             


Gly Thr Asn Tyr Lys Asn Gln Asn Asn Ala Thr Phe Thr Ser Phe Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Asp Gln His Thr Val Lys Leu Ile Lys Thr His Ser 
305                 310                 315                 320 


Asp Glu Lys Asn Pro Ser 
                325     


<210>  108
<211>  326
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synergohymenotropic toxin amino acid sequence

<400>  108

Met Lys Ile Ser Lys Val Ile Lys Ala Ala Thr Ala Thr Ser Val Ala 
1               5                   10                  15      


Leu Met Leu Phe Ser Asn Pro Val Tyr Ala Ala Asn Gln Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Asn Leu Asn Ile Ser Gln Leu Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Ser Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Ile Tyr Ser Ser Phe Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ala Glu Ser Lys Gly Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Ser Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Lys Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Glu Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Lys His Thr Asp Asn Lys Thr Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Ala Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Asp Leu Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Lys Leu Asn Ala Gly Gln Asn Phe Leu Pro Thr Arg Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Lys Pro Asn Gly Ala Lys Thr Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Glu Tyr Thr Asn Tyr Trp Asn Gly Phe His Trp Met 
        275                 280                 285             


Gly Thr Asn Tyr Lys Asn Gln Asn Asn Ala Thr Phe Thr Ser Phe Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Asp Gln His Thr Val Lys Leu Ile Lys Thr His Ser 
305                 310                 315                 320 


Asp Glu Lys Asn Pro Ser 
                325     


<210>  109
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  109

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Glu Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Ile Asn Lys 
                325 


<210>  110
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  110

Met Asn Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Glu Arg Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Ile Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Tyr Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Ile Asn Lys 
                325 


<210>  111
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  111

Met Asn Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Glu Arg Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Ile Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  112
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  112

Met Lys Met Lys Lys Leu Val Lys Ser Ser Val Ala Ser Ser Ile Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Val Asp Ala Ala Gln His Ile Thr Pro 
            20                  25                  30          


Val Ser Glu Lys Lys Val Asp Asp Lys Ile Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ser Asp Asn Asp Lys Leu Asn Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Lys Lys Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asn Tyr Ser Gln Phe Tyr Trp Gly Gly Lys Tyr Asn Val Ser Val 
            100                 105                 110         


Ser Ser Glu Ser Asn Asp Ala Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Gln Thr Leu Gly Tyr Ser Tyr 
    130                 135                 140                 


Gly Gly Asp Ile Asn Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Ile Asp Arg Lys Thr Asn His Lys Ser Ile Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Tyr Asp Pro Thr Tyr Gly Asn Glu Leu Phe Leu Gly Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Asn Ala Gly Gln Asn Phe Leu Pro Thr His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ala Arg Gly Asn Phe Asn Pro Glu Phe Ile Ser Val Leu Ser 
                245                 250                 255     


His Lys Gln Asn Asp Thr Lys Lys Ser Lys Ile Lys Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Arg Tyr Thr Asn Gln 
        275                 280     


<210>  113
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  113

Met Asn Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  114
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  114

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Asn Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  115
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  115

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Cys Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  116
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  116

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Arg Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  117
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  117

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  118
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component C precursor amino acid sequence

<400>  118

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Thr Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  119
<211>  325
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  119

Met Asn Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Ala Gly Asn Ile Asn Ser Gly Tyr Glu Arg Pro Asn Pro Lys Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Ile Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Ile Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ser Ser Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln 
            260                 265                 270         


Arg Glu Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala 
        275                 280                 285             


Gly Ala Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr 
    290                 295                 300                 


Glu Ile Asp Trp Glu Asn His Lys Val Lys Leu Leu Gly Thr Lys Glu 
305                 310                 315                 320 


Thr Glu Asn Asn Lys 
                325 


<210>  120
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Leukocidin-F subunit amino acid sequence

<400>  120

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Gly Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Ala Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val Glu 
            180                 185                 190         


Ala His Lys Ile Met Asn Gly Trp Gly Pro Tyr Gly Arg Asp Ser Phe 
        195                 200                 205             


His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln Ser Ser 
    210                 215                 220                 


Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro Leu Leu 
225                 230                 235                 240 


Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser His Arg 
                245                 250                 255     


Gln Asp Arg Ala Lys Lys Ser Lys Ile Thr Val Thr Tyr Gln Arg Glu 
            260                 265                 270         


Met Asp Leu Tyr Gln Ile Arg Trp Asn Gly Phe Tyr Trp Ala Gly Ala 
        275                 280                 285             


Asn Tyr Lys Asn Phe Lys Thr Arg Thr Phe Lys Ser Thr Tyr Glu Ile 
    290                 295                 300                 


Asp Trp Glu Asn His Lys Val Lys Leu Leu Asp Thr Lys Glu Thr Glu 
305                 310                 315                 320 


Asn Asn Lys 
            


<210>  121
<211>  268
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  121

Met Lys Met Asn Lys Leu Val Lys Ser Ser Val Ala Thr Ser Met Ala 
1               5                   10                  15      


Leu Leu Leu Leu Ser Ser Thr Ala Asn Ala Glu Gly Lys Ile Thr Pro 
            20                  25                  30          


Val Ser Val Lys Lys Val Asp Asp Lys Val Thr Leu Tyr Lys Thr Thr 
        35                  40                  45              


Ala Thr Ala Asp Ser Asp Lys Phe Lys Ile Ser Gln Ile Leu Thr Phe 
    50                  55                  60                  


Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys Asp Thr Leu Val Leu Lys 
65                  70                  75                  80  


Ala Thr Gly Asn Ile Asn Ser Gly Phe Val Lys Pro Asn Pro Asn Asp 
                85                  90                  95      


Tyr Asp Phe Ser Lys Leu Tyr Trp Gly Ala Lys Tyr Asn Val Ser Ile 
            100                 105                 110         


Ser Ser Gln Ser Asn Asp Ser Val Asn Val Val Asp Tyr Ala Pro Lys 
        115                 120                 125             


Asn Gln Asn Glu Glu Phe Gln Val Gln Asn Thr Leu Gly Tyr Thr Phe 
    130                 135                 140                 


Gly Gly Asp Ile Ser Ile Ser Asn Gly Leu Ser Gly Gly Leu Asn Gly 
145                 150                 155                 160 


Asn Thr Ala Phe Ser Glu Thr Ile Asn Tyr Lys Gln Glu Ser Tyr Arg 
                165                 170                 175     


Thr Thr Leu Ser Arg Asn Thr Asn Tyr Lys Asn Val Gly Trp Gly Val 
            180                 185                 190         


Glu Ala His Lys Ile Met Asn Asn Gly Trp Gly Pro Tyr Gly Arg Asp 
        195                 200                 205             


Ser Phe His Pro Thr Tyr Gly Asn Glu Leu Phe Leu Ala Gly Arg Gln 
    210                 215                 220                 


Ser Ile Ala Tyr Ala Gly Gln Asn Phe Ile Ala Gln His Gln Met Pro 
225                 230                 235                 240 


Leu Leu Ser Arg Ser Asn Phe Asn Pro Glu Phe Leu Ser Val Leu Ser 
                245                 250                 255     


His Arg Gln Asp Gly Ala Lys Asn Leu Lys Leu Gln 
            260                 265             


<210>  122
<211>  236
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  gamma-hemolysin component B amino acid sequence

<400>  122

Met Lys Pro Asn Pro Asn Asp Tyr Asp Phe Ser Lys Leu Tyr Trp Gly 
1               5                   10                  15      


Ala Lys Tyr Asn Val Ser Ile Ser Ser Gln Ser Asn Asp Ser Val Asn 
            20                  25                  30          


Val Val Asp Tyr Ala Pro Lys Asn Gln Asn Glu Glu Phe Gln Val Gln 
        35                  40                  45              


Asn Thr Leu Gly Tyr Thr Phe Gly Gly Asp Ile Ser Ile Ser Asn Gly 
    50                  55                  60                  


Leu Ser Gly Gly Leu Asn Gly Asn Thr Ala Phe Ser Glu Thr Ile Asn 
65                  70                  75                  80  


Tyr Lys Gln Glu Ser Tyr Arg Thr Thr Leu Ser Arg Asn Thr Asn Tyr 
                85                  90                  95      


Lys Asn Val Gly Trp Gly Val Glu Ala His Lys Ile Met Asn Asn Gly 
            100                 105                 110         


Trp Gly Pro Tyr Gly Arg Asp Ser Phe His Pro Thr Tyr Gly Asn Glu 
        115                 120                 125             


Leu Phe Leu Ala Gly Arg Gln Ser Ser Ala Tyr Ala Gly Gln Asn Phe 
    130                 135                 140                 


Ile Ala Gln His Gln Met Pro Leu Leu Ser Arg Ser Asn Phe Asn Pro 
145                 150                 155                 160 


Glu Phe Leu Ser Val Leu Ser His Arg Gln Asp Gly Ala Lys Lys Ser 
                165                 170                 175     


Lys Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Leu Tyr Gln Ile Arg 
            180                 185                 190         


Trp Asn Gly Phe Tyr Trp Ala Gly Ala Asn Tyr Lys Asn Phe Lys Thr 
        195                 200                 205             


Arg Thr Phe Lys Ser Thr Tyr Glu Ile Asp Trp Glu Asn His Lys Val 
    210                 215                 220                 


Lys Leu Leu Asp Thr Lys Glu Thr Glu Asn Asn Lys 
225                 230                 235     


<210>  123
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the wild-type LukS-PV

<400>  123
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt cacacaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tccttcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  124
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (K97A) LukS-PV

<400>  124
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt cacacaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctgc aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tccttcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  125
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (D102A) LukS-PV

<400>  125
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt cacacaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gcttcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tccttcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  126
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (Y131A) LukS-PV

<400>  126
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt cacacaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

gcatcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tccttcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  127
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (S209A) LukS-PV

<400>  127
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt cacacaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

gcatcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tcctgcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  128
<211>  4184
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (T28F) LukS-PV

<400>  128
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt ctttcaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tccttcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2280

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2340

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2400

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2460

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2520

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2580

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2640

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2700

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2760

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2820

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     2880

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     2940

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3000

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3060

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3120

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3180

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3240

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3300

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3360

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3420

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3480

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3540

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3600

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3660

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3720

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3780

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3840

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     3900

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     3960

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4020

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4080

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4140

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4184


<210>  129
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (T28F/Y131A) LukS-PV

<400>  129
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt ctttcaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gcttcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tccttcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  130
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (T28F/S209A) LukS-PV

<400>  130
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt ctttcaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctaa aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tcctgcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  131
<211>  4304
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (T28F/K97A/Y131A) LukS-PV

<400>  131
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gataacaata ttgagaatat tggtgatggc      180

gctgaggtag tcaaaagaac agaagataca agtagcgata agtggggggt ctttcaaaat      240

attcagtttg attttgttaa agataaaaag tataacaaag acgctttgat tttaaaaatg      300

caaggtttta tcaattcaaa gactacttat tacaattaca aaaacacaga tcatataaaa      360

gcaatgaggt ggcctttcca atacaatatt ggtctcaaaa caaatgaccc caatgtagat      420

ttaataaatt atctacctgc aaataaaata gattcagtaa atgttagtca aacattaggt      480

tataacatag gtggtaattt taatagtggt ccatcaacag gaggtaatgg ttcatttaat      540

tattcaaaaa caattagtta taatcaacaa aactatatca gtgaagtaga acatcaaaat      600

tcaaaaagtg ttcaatgggg aataaaagct aattcattta tcacatcatt aggtaaaatg      660

tctggacatg atccaaattt atttgttgga tataaaccat atagtcaaaa tccgagagac      720

tattttgtgc cagacaatga attaccccca ttagtacaca gtggtttcaa tcctgcattt      780

attgcaactg tttctcatga aaaaggctca ggagatacaa gtgaatttga aataacgtat      840

ggcagaaata tggatgttac tcatgctact agaagaacaa cacactatgg caatagttat      900

ttagaaggat ctagaataca caacgcattt gtaaacagaa attacacagt taaatatgaa      960

gtgaactgga aaactcatga aattaaagtg aaaggacata attgaggtac cccgggtcga     1020

cctgcagcca agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct     1080

cagaactcca tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg     1140

agaatccaag ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa     1200

atcactggat ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca     1260

tttcagtcag ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt     1320

ttaaagaccg taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc     1380

cgcctgatga atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata     1440

tgggatagtg ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg     1500

ctctggagtg aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg     1560

gcgtgttacg gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc     1620

gtctcagcca atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac     1680

aacttcttcg cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg     1740

atgccgctgg cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg     1800

cttaatgaat tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc     1860

agttattggt gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa     1920

acgaaaggct cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc     1980

tctcctgagt aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt     2040

gaaaacctct gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc     2100

gggagcagac aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc     2160

atgacccagt cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc     2220

agattgtact gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa     2280

aataccgcat caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc     2340

ggctgcggcg agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag     2400

gggataacgc aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa     2460

aggccgcgtt gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc     2520

gacgctcaag tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc     2580

ctggaagctc cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg     2640

cctttctccc ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt     2700

cggtgtaggt cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc     2760

gctgcgcctt atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc     2820

cactggcagc agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag     2880

agttcttgaa gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg     2940

ctctgctgaa gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa     3000

ccaccgctgg tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag     3060

gatctcaaga agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact     3120

cacgttaagg gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa     3180

attaaaaatg aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt     3240

accaatgctt aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag     3300

ttgcctgact ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca     3360

gtgctgcaat gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc     3420

agccagccgg aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt     3480

ctattaattg ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg     3540

ttgttgccat tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca     3600

gctccggttc ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg     3660

ttagctcctt cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca     3720

tggttatggc agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg     3780

tgactggtga gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct     3840

cttgcccggc gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca     3900

tcattggaaa acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca     3960

gttcgatgta acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg     4020

tttctgggtg agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac     4080

ggaaatgttg aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt     4140

attgtctcat gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc     4200

cgcgcacatt tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat     4260

taacctataa aaataggcgt atcacgaggc cctttcgtct tcac                      4304


<210>  132
<211>  2375
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the wild-type LukF-PV

<400>  132
tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag       60

taggacaaat ccgccctcta gagctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc      120

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga      180

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgacccag      240

tcacgtagcg atagcggagt gtatactggc ttaactatgc ggcatcagag cagattgtac      300

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca      360

tcaggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc      420

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg      480

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt      540

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa      600

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct      660

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc      720

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg      780

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct      840

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag      900

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga      960

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     1020

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     1080

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     1140

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     1200

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     1260

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     1320

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     1380

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     1440

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     1500

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     1560

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     1620

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     1680

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     1740

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     1800

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     1860

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     1920

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     1980

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     2040

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     2100

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     2160

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     2220

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     2280

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     2340

aaaataggcg tatcacgagg ccctttcgtc ttcac                                2375


<210>  133
<211>  4355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (K102A) LukF-PV

<400>  133
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gctcaacata tcacacctgt aagtgagaaa      180

aaggttgatg ataaaattac tttgtacaaa acaactgcaa catcagattc cgataagtta      240

aaaatttctc agattttaac ttttaatttt attaaagata aaagttatga taaagataca      300

ttaatactca aagctgctgg aaacatttat tctggctata caaagccaaa tccaaaagac      360

actattagtt ctcaatttta ttggggttct aagtacaaca tttcaattaa ttcagattct      420

aatgactcag taaacgttgt agattatgca cctgcaaatc aaaatgaaga atttcaagta      480

caacaaacgg taggttattc ttatggtgga gatattaata tctctaacgg cttatcaggt      540

ggaggtaatg gttcaaaatc tttttcagag acaattaact ataaacaaga aagctataga      600

actagcttag ataaaagaac taatttcaaa aaaattggtt gggatgttga agcacataaa      660

attatgaata atggttgggg accatatggc agagatagtt atcattcaac ttatggtaat      720

gaaatgtttt taggctcaag acaaagcaac ttaaatgctg gacaaaactt cttggaatat      780

cacaaaatgc cagtgttatc cagaggtaac ttcaatccag aatttattgg tgtcctatct      840

cgaaaacaaa acgctgcaaa aaaatcaaaa attactgtta cttatcaaag agaaatggat      900

agatatacaa acttttggaa tcaacttcac tggataggta ataattataa agatgaaaat      960

agagcaactc atacatcaat ttatgaagtt gattgggaaa atcatacagt taaattaata     1020

gatactcaat ctaaggaaaa aaatcctatg agctaaggta ccccgggtcg acctgcagcc     1080

aagcttaatt agctgagctt ggactcctgt tgatagatcc agtaatgacc tcagaactcc     1140

atctggattt gttcagaacg ctcggttgcc gccgggcgtt ttttattggt gagaatccaa     1200

gctagcttgg cgagattttc aggagctaag gaagctaaaa tggagaaaaa aatcactgga     1260

tataccaccg ttgatatatc ccaatggcat cgtaaagaac attttgaggc atttcagtca     1320

gttgctcaat gtacctataa ccagaccgtt cagctggata ttacggcctt tttaaagacc     1380

gtaaagaaaa ataagcacaa gttttatccg gcctttattc acattcttgc ccgcctgatg     1440

aatgctcatc cggaatttcg tatggcaatg aaagacggtg agctggtgat atgggatagt     1500

gttcaccctt gttacaccgt tttccatgag caaactgaaa cgttttcatc gctctggagt     1560

gaataccacg acgatttccg gcagtttcta cacatatatt cgcaagatgt ggcgtgttac     1620

ggtgaaaacc tggcctattt ccctaaaggg tttattgaga atatgttttt cgtctcagcc     1680

aatccctggg tgagtttcac cagttttgat ttaaacgtgg ccaatatgga caacttcttc     1740

gcccccgttt tcaccatggg caaatattat acgcaaggcg acaaggtgct gatgccgctg     1800

gcgattcagg ttcatcatgc cgtttgtgat ggcttccatg tcggcagaat gcttaatgaa     1860

ttacaacagt actgcgatga gtggcagggc ggggcgtaat ttttttaagg cagttattgg     1920

tgcccttaaa cgcctggggt aatgactctc tagcttgagg catcaaataa aacgaaaggc     1980

tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag     2040

taggacaaat ccgccctcta gagctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc     2100

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     2160

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgacccag     2220

tcacgtagcg atagcggagt gtatactggc ttaactatgc ggcatcagag cagattgtac     2280

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     2340

tcaggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     2400

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     2460

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     2520

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     2580

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     2640

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     2700

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     2760

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     2820

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     2880

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     2940

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     3000

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     3060

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     3120

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     3180

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     3240

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     3300

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     3360

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     3420

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     3480

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     3540

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     3600

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     3660

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     3720

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     3780

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     3840

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     3900

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     3960

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     4020

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     4080

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     4140

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     4200

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     4260

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     4320

aaaataggcg tatcacgagg ccctttcgtc ttcac                                4355


<210>  134
<211>  4354
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (D121A) LukF-PV

<400>  134
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gctcaacata tcacacctgt aagtgagaaa      180

aaggttgatg ataaaattac tttgtacaaa acaactgcaa catcagattc cgataagtta      240

aaaatttctc agattttaac ttttaatttt attaaagata aaagttatga taaagataca      300

ttaatactca aagctgctgg aaacatttat tctggctata caaagccaaa tccaaaagac      360

actattagtt ctcaatttta ttggggttct aagtacaaca tttcaattaa ttcagattct      420

aatgactcag taaacgttgt agattatgca cctaaaaatc aaaatgaaga atttcaagta      480

caacaaacgg taggttattc ttatggtgga gctattaata tctctaacgg cttatcaggt      540

ggaggtaatg gttcaaaatc tttttcagag acaattaact ataaacaaga agctatagaa      600

ctagcttaga taaaagaact aatttcaaaa aaattggttg ggatgttgaa gcacataaaa      660

ttatgaataa tggttgggga ccatatggca gagatagtta tcattcaact tatggtaatg      720

aaatgttttt aggctcaaga caaagcaact taaatgctgg acaaaacttc ttggaatatc      780

acaaaatgcc agtgttatcc agaggtaact tcaatccaga atttattggt gtcctatctc      840

gaaaacaaaa cgctgcaaaa aaatcaaaaa ttactgttac ttatcaaaga gaaatggata      900

gatatacaaa cttttggaat caacttcact ggataggtaa taattataaa gatgaaaata      960

gagcaactca tacatcaatt tatgaagttg attgggaaaa tcatacagtt aaattaatag     1020

atactcaatc taaggaaaaa aatcctatga gctaaggtac cccgggtcga cctgcagcca     1080

agcttaatta gctgagcttg gactcctgtt gatagatcca gtaatgacct cagaactcca     1140

tctggatttg ttcagaacgc tcggttgccg ccgggcgttt tttattggtg agaatccaag     1200

ctagcttggc gagattttca ggagctaagg aagctaaaat ggagaaaaaa atcactggat     1260

ataccaccgt tgatatatcc caatggcatc gtaaagaaca ttttgaggca tttcagtcag     1320

ttgctcaatg tacctataac cagaccgttc agctggatat tacggccttt ttaaagaccg     1380

taaagaaaaa taagcacaag ttttatccgg cctttattca cattcttgcc cgcctgatga     1440

atgctcatcc ggaatttcgt atggcaatga aagacggtga gctggtgata tgggatagtg     1500

ttcacccttg ttacaccgtt ttccatgagc aaactgaaac gttttcatcg ctctggagtg     1560

aataccacga cgatttccgg cagtttctac acatatattc gcaagatgtg gcgtgttacg     1620

gtgaaaacct ggcctatttc cctaaagggt ttattgagaa tatgtttttc gtctcagcca     1680

atccctgggt gagtttcacc agttttgatt taaacgtggc caatatggac aacttcttcg     1740

cccccgtttt caccatgggc aaatattata cgcaaggcga caaggtgctg atgccgctgg     1800

cgattcaggt tcatcatgcc gtttgtgatg gcttccatgt cggcagaatg cttaatgaat     1860

tacaacagta ctgcgatgag tggcagggcg gggcgtaatt tttttaaggc agttattggt     1920

gcccttaaac gcctggggta atgactctct agcttgaggc atcaaataaa acgaaaggct     1980

cagtcgaaag actgggcctt tcgttttatc tgttgtttgt cggtgaacgc tctcctgagt     2040

aggacaaatc cgccctctag agctgcctcg cgcgtttcgg tgatgacggt gaaaacctct     2100

gacacatgca gctcccggag acggtcacag cttgtctgta agcggatgcc gggagcagac     2160

aagcccgtca gggcgcgtca gcgggtgttg gcgggtgtcg gggcgcagcc atgacccagt     2220

cacgtagcga tagcggagtg tatactggct taactatgcg gcatcagagc agattgtact     2280

gagagtgcac catatgcggt gtgaaatacc gcacagatgc gtaaggagaa aataccgcat     2340

caggcgctct tccgcttcct cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg     2400

agcggtatca gctcactcaa aggcggtaat acggttatcc acagaatcag gggataacgc     2460

aggaaagaac atgtgagcaa aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt     2520

gctggcgttt ttccataggc tccgcccccc tgacgagcat cacaaaaatc gacgctcaag     2580

tcagaggtgg cgaaacccga caggactata aagataccag gcgtttcccc ctggaagctc     2640

cctcgtgcgc tctcctgttc cgaccctgcc gcttaccgga tacctgtccg cctttctccc     2700

ttcgggaagc gtggcgcttt ctcatagctc acgctgtagg tatctcagtt cggtgtaggt     2760

cgttcgctcc aagctgggct gtgtgcacga accccccgtt cagcccgacc gctgcgcctt     2820

atccggtaac tatcgtcttg agtccaaccc ggtaagacac gacttatcgc cactggcagc     2880

agccactggt aacaggatta gcagagcgag gtatgtaggc ggtgctacag agttcttgaa     2940

gtggtggcct aactacggct acactagaag gacagtattt ggtatctgcg ctctgctgaa     3000

gccagttacc ttcggaaaaa gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg     3060

tagcggtggt ttttttgttt gcaagcagca gattacgcgc agaaaaaaag gatctcaaga     3120

agatcctttg atcttttcta cggggtctga cgctcagtgg aacgaaaact cacgttaagg     3180

gattttggtc atgagattat caaaaaggat cttcacctag atccttttaa attaaaaatg     3240

aagttttaaa tcaatctaaa gtatatatga gtaaacttgg tctgacagtt accaatgctt     3300

aatcagtgag gcacctatct cagcgatctg tctatttcgt tcatccatag ttgcctgact     3360

ccccgtcgtg tagataacta cgatacggga gggcttacca tctggcccca gtgctgcaat     3420

gataccgcga gacccacgct caccggctcc agatttatca gcaataaacc agccagccgg     3480

aagggccgag cgcagaagtg gtcctgcaac tttatccgcc tccatccagt ctattaattg     3540

ttgccgggaa gctagagtaa gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat     3600

tgctacaggc atcgtggtgt cacgctcgtc gtttggtatg gcttcattca gctccggttc     3660

ccaacgatca aggcgagtta catgatcccc catgttgtgc aaaaaagcgg ttagctcctt     3720

cggtcctccg atcgttgtca gaagtaagtt ggccgcagtg ttatcactca tggttatggc     3780

agcactgcat aattctctta ctgtcatgcc atccgtaaga tgcttttctg tgactggtga     3840

gtactcaacc aagtcattct gagaatagtg tatgcggcga ccgagttgct cttgcccggc     3900

gtcaatacgg gataataccg cgccacatag cagaacttta aaagtgctca tcattggaaa     3960

acgttcttcg gggcgaaaac tctcaaggat cttaccgctg ttgagatcca gttcgatgta     4020

acccactcgt gcacccaact gatcttcagc atcttttact ttcaccagcg tttctgggtg     4080

agcaaaaaca ggaaggcaaa atgccgcaaa aaagggaata agggcgacac ggaaatgttg     4140

aatactcata ctcttccttt ttcaatatta ttgaagcatt tatcagggtt attgtctcat     4200

gagcggatac atatttgaat gtatttagaa aaataaacaa ataggggttc cgcgcacatt     4260

tccccgaaaa gtgccacctg acgtctaaga aaccattatt atcatgacat taacctataa     4320

aaataggcgt atcacgaggc cctttcgtct tcac                                 4354


<210>  135
<211>  4355
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  plasmid construct encoding the mutant (E147A) LukF-PV

<400>  135
ctcgagaaat cataaaaaat ttatttgctt tgtgagcgga taacaattat aatagattca       60

attgtgagcg gataacaatt tcacacagaa ttcattaaag aggagaaatt aactatgaga      120

ggatcgcatc accatcacca tcacggatcc gctcaacata tcacacctgt aagtgagaaa      180

aaggttgatg ataaaattac tttgtacaaa acaactgcaa catcagattc cgataagtta      240

aaaatttctc agattttaac ttttaatttt attaaagata aaagttatga taaagataca      300

ttaatactca aagctgctgg aaacatttat tctggctata caaagccaaa tccaaaagac      360

actattagtt ctcaatttta ttggggttct aagtacaaca tttcaattaa ttcagattct      420

aatgactcag taaacgttgt agattatgca cctaaaaatc aaaatgaaga atttcaagta      480

caacaaacgg taggttattc ttatggtgga gatattaata tctctaacgg cttatcaggt      540

ggaggtaatg gttcaaaatc tttttcagag acaattaact ataaacaagc aagctataga      600

actagcttag ataaaagaac taatttcaaa aaaattggtt gggatgttga agcacataaa      660

attatgaata atggttgggg accatatggc agagatagtt atcattcaac ttatggtaat      720

gaaatgtttt taggctcaag acaaagcaac ttaaatgctg gacaaaactt cttggaatat      780

cacaaaatgc cagtgttatc cagaggtaac ttcaatccag aatttattgg tgtcctatct      840

cgaaaacaaa acgctgcaaa aaaatcaaaa attactgtta cttatcaaag agaaatggat      900

agatatacaa acttttggaa tcaacttcac tggataggta ataattataa agatgaaaat      960

agagcaactc atacatcaat ttatgaagtt gattgggaaa atcatacagt taaattaata     1020

gatactcaat ctaaggaaaa aaatcctatg agctaaggta ccccgggtcg acctgcagcc     1080

aagcttaatt agctgagctt ggactcctgt tgatagatcc agtaatgacc tcagaactcc     1140

atctggattt gttcagaacg ctcggttgcc gccgggcgtt ttttattggt gagaatccaa     1200

gctagcttgg cgagattttc aggagctaag gaagctaaaa tggagaaaaa aatcactgga     1260

tataccaccg ttgatatatc ccaatggcat cgtaaagaac attttgaggc atttcagtca     1320

gttgctcaat gtacctataa ccagaccgtt cagctggata ttacggcctt tttaaagacc     1380

gtaaagaaaa ataagcacaa gttttatccg gcctttattc acattcttgc ccgcctgatg     1440

aatgctcatc cggaatttcg tatggcaatg aaagacggtg agctggtgat atgggatagt     1500

gttcaccctt gttacaccgt tttccatgag caaactgaaa cgttttcatc gctctggagt     1560

gaataccacg acgatttccg gcagtttcta cacatatatt cgcaagatgt ggcgtgttac     1620

ggtgaaaacc tggcctattt ccctaaaggg tttattgaga atatgttttt cgtctcagcc     1680

aatccctggg tgagtttcac cagttttgat ttaaacgtgg ccaatatgga caacttcttc     1740

gcccccgttt tcaccatggg caaatattat acgcaaggcg acaaggtgct gatgccgctg     1800

gcgattcagg ttcatcatgc cgtttgtgat ggcttccatg tcggcagaat gcttaatgaa     1860

ttacaacagt actgcgatga gtggcagggc ggggcgtaat ttttttaagg cagttattgg     1920

tgcccttaaa cgcctggggt aatgactctc tagcttgagg catcaaataa aacgaaaggc     1980

tcagtcgaaa gactgggcct ttcgttttat ctgttgtttg tcggtgaacg ctctcctgag     2040

taggacaaat ccgccctcta gagctgcctc gcgcgtttcg gtgatgacgg tgaaaacctc     2100

tgacacatgc agctcccgga gacggtcaca gcttgtctgt aagcggatgc cgggagcaga     2160

caagcccgtc agggcgcgtc agcgggtgtt ggcgggtgtc ggggcgcagc catgacccag     2220

tcacgtagcg atagcggagt gtatactggc ttaactatgc ggcatcagag cagattgtac     2280

tgagagtgca ccatatgcgg tgtgaaatac cgcacagatg cgtaaggaga aaataccgca     2340

tcaggcgctc ttccgcttcc tcgctcactg actcgctgcg ctcggtcgtt cggctgcggc     2400

gagcggtatc agctcactca aaggcggtaa tacggttatc cacagaatca ggggataacg     2460

caggaaagaa catgtgagca aaaggccagc aaaaggccag gaaccgtaaa aaggccgcgt     2520

tgctggcgtt tttccatagg ctccgccccc ctgacgagca tcacaaaaat cgacgctcaa     2580

gtcagaggtg gcgaaacccg acaggactat aaagatacca ggcgtttccc cctggaagct     2640

ccctcgtgcg ctctcctgtt ccgaccctgc cgcttaccgg atacctgtcc gcctttctcc     2700

cttcgggaag cgtggcgctt tctcatagct cacgctgtag gtatctcagt tcggtgtagg     2760

tcgttcgctc caagctgggc tgtgtgcacg aaccccccgt tcagcccgac cgctgcgcct     2820

tatccggtaa ctatcgtctt gagtccaacc cggtaagaca cgacttatcg ccactggcag     2880

cagccactgg taacaggatt agcagagcga ggtatgtagg cggtgctaca gagttcttga     2940

agtggtggcc taactacggc tacactagaa ggacagtatt tggtatctgc gctctgctga     3000

agccagttac cttcggaaaa agagttggta gctcttgatc cggcaaacaa accaccgctg     3060

gtagcggtgg tttttttgtt tgcaagcagc agattacgcg cagaaaaaaa ggatctcaag     3120

aagatccttt gatcttttct acggggtctg acgctcagtg gaacgaaaac tcacgttaag     3180

ggattttggt catgagatta tcaaaaagga tcttcaccta gatcctttta aattaaaaat     3240

gaagttttaa atcaatctaa agtatatatg agtaaacttg gtctgacagt taccaatgct     3300

taatcagtga ggcacctatc tcagcgatct gtctatttcg ttcatccata gttgcctgac     3360

tccccgtcgt gtagataact acgatacggg agggcttacc atctggcccc agtgctgcaa     3420

tgataccgcg agacccacgc tcaccggctc cagatttatc agcaataaac cagccagccg     3480

gaagggccga gcgcagaagt ggtcctgcaa ctttatccgc ctccatccag tctattaatt     3540

gttgccggga agctagagta agtagttcgc cagttaatag tttgcgcaac gttgttgcca     3600

ttgctacagg catcgtggtg tcacgctcgt cgtttggtat ggcttcattc agctccggtt     3660

cccaacgatc aaggcgagtt acatgatccc ccatgttgtg caaaaaagcg gttagctcct     3720

tcggtcctcc gatcgttgtc agaagtaagt tggccgcagt gttatcactc atggttatgg     3780

cagcactgca taattctctt actgtcatgc catccgtaag atgcttttct gtgactggtg     3840

agtactcaac caagtcattc tgagaatagt gtatgcggcg accgagttgc tcttgcccgg     3900

cgtcaatacg ggataatacc gcgccacata gcagaacttt aaaagtgctc atcattggaa     3960

aacgttcttc ggggcgaaaa ctctcaagga tcttaccgct gttgagatcc agttcgatgt     4020

aacccactcg tgcacccaac tgatcttcag catcttttac tttcaccagc gtttctgggt     4080

gagcaaaaac aggaaggcaa aatgccgcaa aaaagggaat aagggcgaca cggaaatgtt     4140

gaatactcat actcttcctt tttcaatatt attgaagcat ttatcagggt tattgtctca     4200

tgagcggata catatttgaa tgtatttaga aaaataaaca aataggggtt ccgcgcacat     4260

ttccccgaaa agtgccacct gacgtctaag aaaccattat tatcatgaca ttaacctata     4320

aaaataggcg tatcacgagg ccctttcgtc ttcac                                4355


<210>  136
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  LukF-PV Triple Mutant

<400>  136

Ala Gln His Ile Thr Pro Val Ser Glu Lys Lys Val Asp Asp Lys Ile 
1               5                   10                  15      


Thr Leu Tyr Lys Thr Thr Ala Thr Ser Asp Ser Asp Lys Leu Lys Ile 
            20                  25                  30          


Ser Gln Ile Leu Thr Phe Asn Phe Ile Lys Asp Lys Ser Tyr Asp Lys 
        35                  40                  45              


Asp Thr Leu Ile Leu Lys Ala Ala Gly Asn Ile Tyr Ser Gly Tyr Thr 
    50                  55                  60                  


Lys Pro Asn Pro Lys Asp Thr Ile Ser Ser Gln Phe Tyr Trp Gly Ser 
65                  70                  75                  80  


Lys Tyr Asn Ile Ser Ile Asn Ser Asp Ser Asn Asp Ser Val Asn Val 
                85                  90                  95      


Val Asp Tyr Ala Pro Ala Asn Gln Asn Glu Glu Phe Gln Val Gln Gln 
            100                 105                 110         


Thr Val Gly Tyr Ser Tyr Gly Gly Ala Ile Asn Ile Ser Asn Gly Leu 
        115                 120                 125             


Ser Gly Gly Gly Asn Gly Ser Lys Ser Phe Ser Glu Thr Ile Asn Tyr 
    130                 135                 140                 


Lys Gln Ala Ser Tyr Arg Thr Ser Leu Asp Lys Arg Thr Asn Phe Lys 
145                 150                 155                 160 


Lys Ile Gly Trp Asp Val Glu Ala His Lys Ile Met Asn Asn Gly Trp 
                165                 170                 175     


Gly Pro Tyr Gly Arg Asp Ser Tyr His Ser Thr Tyr Gly Asn Glu Met 
            180                 185                 190         


Phe Leu Gly Ser Arg Gln Ser Asn Leu Asn Ala Gly Gln Asn Phe Leu 
        195                 200                 205             


Glu Tyr His Lys Met Pro Val Leu Ser Arg Gly Asn Phe Asn Pro Glu 
    210                 215                 220                 


Phe Ile Gly Val Leu Ser Arg Lys Gln Asn Ala Ala Lys Lys Ser Lys 
225                 230                 235                 240 


Ile Thr Val Thr Tyr Gln Arg Glu Met Asp Arg Tyr Thr Asn Phe Trp 
                245                 250                 255     


Asn Gln Leu His Trp Ile Gly Asn Asn Tyr Lys Asp Glu Asn Arg Ala 
            260                 265                 270         


Thr His Thr Ser Ile Tyr Glu Val Asp Trp Glu Asn His Thr Val Lys 
        275                 280                 285             


Leu Ile Asp Thr Gln Ser Lys Glu Lys Asn Pro Met Ser 
    290                 295                 300     


<210>  137
<211>  948
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  polynucleotide sequence of Triple PVLF

<400>  137
atgagaggat cgcatcacca tcaccatcac ggatccgctc aacatatcac acctgtaagt       60

gagaaaaagg ttgatgataa aattactttg tacaaaacaa ctgcaacatc agattccgat      120

aagttaaaaa tttctcagat tttaactttt aattttatta aagataaaag ttatgataaa      180

gatacattaa tactcaaagc tgctggaaac atttattctg gctatacaaa gccaaatcca      240

aaagacacta ttagttctca attttattgg ggttctaagt acaacatttc aattaattca      300

gattctaatg actcagtaaa cgttgtagat tatgcacctg caaatcaaaa tgaagaattt      360

caagtacaac aaacggtagg ttattcttat ggtggagcta ttaatatctc taacggctta      420

tcaggtggag gtaatggttc aaaatctttt tcagagacaa ttaactataa acaagcaagc      480

tatagaacta gcttagataa aagaactaat ttcaaaaaaa ttggttggga tgttgaagca      540

cataaaatta tgaataatgg ttggggacca tatggcagag atagttatca ttcaacttat      600

ggtaatgaaa tgtttttagg ctcaagacaa agcaacttaa atgctggaca aaacttcttg      660

gaatatcaca aaatgccagt gttatccaga ggtaacttca atccagaatt tattggtgtc      720

ctatctcgaa aacaaaacgc tgcaaaaaaa tcaaaaatta ctgttactta tcaaagagaa      780

atggatagat atacaaactt ttggaatcaa cttcactgga taggtaataa ttataaagat      840

gaaaatagag caactcatac atcaatttat gaagttgatt gggaaaatca tacagttaaa      900

ttaatagata ctcaatctaa ggaaaaaaat cctatgagct aaggtacc                   948
