
                                SEQUENCE LISTING

<110> Lin Chang
      Emeran A. Mayer
      The Regents of the University of California

<120> GLUCORTICOID RECEPTOR GENE Nr3c1
  METHYLATION IN IRRITABLE BOWEL SYNDROME AND OTHER STRESS
  DISORDERS

<130> 30435249WOU1

<150> 61/564,761          
<151> 2011-11-29  

<160> 15

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 70
<212> DNA
<213> Homo Sapiens

<400> 1
gcgcttgccg ccaaggggca gagcgagctc ccgagtgggt ctggagccgc ggagctgggc 60
gggggcggga                                                        70

<210> 2
<211> 6801
<212> DNA
<213> Homo Sapiens

<400> 2
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct 60
ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc 120
tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag 180
acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac 240
ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga 300
ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt 360
tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt 420
ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt 480
tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc 540
agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga 600
gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc 660
aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca 720
gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa 780
gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa 840
acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca 900
gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt 960
ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc 1020
aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat 1080
ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac 1140
ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt 1200
ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa 1260
attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg 1320
aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa 1380
ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg 1440
tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg 1500
aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca 1560
attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact 1620
tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc 1680
agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca 1740
cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta 1800
acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta 1860
tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc 1920
cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa 1980
ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt 2040
aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg 2100
gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact 2160
tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa 2220
tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg 2280
cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca 2340
agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta 2400
ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt 2460
caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct 2520
aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag 2580
ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat 2640
caactgacaa aactcttgga ttctatgcat gaagtggttg aaaatctcct taactattgc 2700
ttccaaacat ttttggataa gaccatgagt attgaattcc ccgagatgtt agctgaaatc 2760
atcaccaatc agataccaaa atattcaaat ggaaatatca aaaaacttct gtttcatcaa 2820
aagtgactgc cttaataaga atggttgcct taaagaaagt cgaattaata gcttttattg 2880
tataaactat cagtttgtcc tgtagaggtt ttgttgtttt attttttatt gttttcatct 2940
gttgttttgt tttaaatacg cactacatgt ggtttataga gggccaagac ttggcaacag 3000
aagcagttga gtcgtcatca cttttcagtg atgggagagt agatggtgaa atttattagt 3060
taatatatcc cagaaattag aaaccttaat atgtggacgt aatctccaca gtcaaagaag 3120
gatggcacct aaaccaccag tgcccaaagt ctgtgtgatg aactttctct tcatactttt 3180
tttcacagtt ggctggatga aattttctag actttctgtt ggtgtatccc ccccctgtat 3240
agttaggata gcatttttga tttatgcatg gaaacctgaa aaaaagttta caagtgtata 3300
tcagaaaagg gaagttgtgc cttttatagc tattactgtc tggttttaac aatttccttt 3360
atatttagtg aactacgctt gctcattttt tcttacataa ttttttattc aagttattgt 3420
acagctgttt aagatgggca gctagttcgt agctttccca aataaactct aaacattaat 3480
caatcatctg tgtgaaaatg ggttggtgct tctaacctga tggcacttag ctatcagaag 3540
accacaaaaa ttgactcaaa tctccagtat tcttgtcaaa aaaaaaaaaa aaaaagctca 3600
tattttgtat atatctgctt cagtggagaa ttatataggt tgtgcaaatt aacagtccta 3660
actggtatag agcacctagt ccagtgacct gctgggtaaa ctgtggatga tggttgcaaa 3720
agactaattt aaaaaataac taccaagagg ccctgtctgt acctaacgcc ctatttttgc 3780
aatggctata tggcaagaaa gctggtaaac tatttgtctt tcaggacctt ttgaagtagt 3840
ttgtataact tcttaaaagt tgtgattcca gataaccagc tgtaacacag ctgagagact 3900
tttaatcaga caaagtaatt cctctcacta aactttaccc aaaaactaaa tctctaatat 3960
ggcaaaaatg gctagacacc cattttcaca ttcccatctg tcaccaattg gttaatcttt 4020
cctgatggta caggaaagct cagctactga tttttgtgat ttagaactgt atgtcagaca 4080
tccatgtttg taaaactaca catccctaat gtgtgccata gagtttaaca caagtcctgt 4140
gaatttcttc actgttgaaa attattttaa acaaaataga agctgtagta gccctttctg 4200
tgtgcacctt accaactttc tgtaaactca aaacttaaca tatttactaa gccacaagaa 4260
atttgatttc tattcaaggt ggccaaatta tttgtgtaat agaaaactga aaatctaata 4320
ttaaaaatat ggaacttcta atatattttt atatttagtt atagtttcag atatatatca 4380
tattggtatt cactaatctg ggaagggaag ggctactgca gctttacatg caatttatta 4440
aaatgattgt aaaatagctt gtatagtgta aaataagaat gatttttaga tgagattgtt 4500
ttatcatgac atgttatata ttttttgtag gggtcaaaga aatgctgatg gataacctat 4560
atgatttata gtttgtacat gcattcatac aggcagcgat ggtctcagaa accaaacagt 4620
ttgctctagg ggaagaggga gatggagact ggtcctgtgt gcagtgaagg ttgctgaggc 4680
tctgacccag tgagattaca gaggaagtta tcctctgcct cccattctga ccacccttct 4740
cattccaaca gtgagtctgt cagcgcaggt ttagtttact caatctcccc ttgcactaaa 4800
gtatgtaaag tatgtaaaca ggagacagga aggtggtgct tacatcctta aaggcaccat 4860
ctaatagcgg gttactttca catacagccc tcccccagca gttgaatgac aacagaagct 4920
tcagaagttt ggcaatagtt tgcatagagg taccagcaat atgtaaatag tgcagaatct 4980
cataggttgc caataataca ctaattcctt tctatcctac aacaagagtt tatttccaaa 5040
taaaatgagg acatgttttt gttttctttg aatgcttttt gaatgttatt tgttattttc 5100
agtattttgg agaaattatt taataaaaaa acaatcattt gctttttgaa tgctctctaa 5160
aagggaatgt aatattttaa gatggtgtgt aacccggctg gataaatttt tggtgcctaa 5220
gaaaactgct tgaatattct tatcaatgac agtgttaagt ttcaaaaaga gcttctaaaa 5280
cgtagattat cattccttta tagaatgtta tgtggttaaa accagaaagc acatctcaca 5340
cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact caatgagaaa 5400
aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat cgacaactat 5460
aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg tgggggaaaa 5520
gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg tgctgtttga 5580
aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac tgttgaagtt 5640
tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta tttttagtgt 5700
ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga cataacactt 5760
ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc accccaaaag 5820
gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga tgagctctgg 5880
gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag caattccagt 5940
ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta catcaccatg 6000
gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac catggtagcc 6060
ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg tgaatgtgtt 6120
tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa ggaggacact 6180
ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa cctggtccac 6240
ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa atgtctgaaa 6300
ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa cttgcttaac 6360
tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta tataatgggg 6420
acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta ttttttatca 6480
cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa ataaaagttg 6540
tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc tttttaccta 6600
cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt attttttcat 6660
ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg cagtaaatgt 6720
tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat ctgctttttc 6780
attaaaaaaa aaaaaaaaaa a                                           6801



<210> 3
<211> 4154
<212> DNA
<213> Homo Sapiens

<400> 3
ggcgccgcct ccacccgctc cccgctcggt cccgctcgct cgcccaggcc gggctgccct 60
ttcgcgtgtc cgcgctctct tccctccgcc gccgcctcct ccattttgcg agctcgtgtc 120
tgtgacggga gcccgagtca ccgcctgccc gtcggggacg gattctgtgg gtggaaggag 180
acgccgcagc cggagcggcc gaagcagctg ggaccgggac ggggcacgcg cgcccggaac 240
ctcgacccgc ggagcccggc gcggggcgga gggctggctt gtcagctggg caatgggaga 300
ctttcttaaa taggggctct ccccccaccc atggagaaag gggcggctgt ttacttcctt 360
tttttagaaa aaaaaaatat atttccctcc tgctccttct gcgttcacaa gctaagttgt 420
ttatctcggc tgcggcggga actgcggacg gtggcgggcg agcggctcct ctgccagagt 480
tgatattcac tgatggactc caaagaatca ttaactcctg gtagagaaga aaaccccagc 540
agtgtgcttg ctcaggagag gggagatgtg atggacttct ataaaaccct aagaggagga 600
gctactgtga aggtttctgc gtcttcaccc tcactggctg tcgcttctca atcagactcc 660
aagcagcgaa gacttttggt tgattttcca aaaggctcag taagcaatgc gcagcagcca 720
gatctgtcca aagcagtttc actctcaatg ggactgtata tgggagagac agaaacaaaa 780
gtgatgggaa atgacctggg attcccacag cagggccaaa tcagcctttc ctcgggggaa 840
acagacttaa agcttttgga agaaagcatt gcaaacctca ataggtcgac cagtgttcca 900
gagaacccca agagttcagc atccactgct gtgtctgctg cccccacaga gaaggagttt 960
ccaaaaactc actctgatgt atcttcagaa cagcaacatt tgaagggcca gactggcacc 1020
aacggtggca atgtgaaatt gtataccaca gaccaaagca cctttgacat tttgcaggat 1080
ttggagtttt cttctgggtc cccaggtaaa gagacgaatg agagtccttg gagatcagac 1140
ctgttgatag atgaaaactg tttgctttct cctctggcgg gagaagacga ttcattcctt 1200
ttggaaggaa actcgaatga ggactgcaag cctctcattt taccggacac taaacccaaa 1260
attaaggata atggagatct ggttttgtca agccccagta atgtaacact gccccaagtg 1320
aaaacagaaa aagaagattt catcgaactc tgcacccctg gggtaattaa gcaagagaaa 1380
ctgggcacag tttactgtca ggcaagcttt cctggagcaa atataattgg taataaaatg 1440
tctgccattt ctgttcatgg tgtgagtacc tctggaggac agatgtacca ctatgacatg 1500
aatacagcat ccctttctca acagcaggat cagaagccta tttttaatgt cattccacca 1560
attcccgttg gttccgaaaa ttggaatagg tgccaaggat ctggagatga caacttgact 1620
tctctgggga ctctgaactt ccctggtcga acagtttttt ctaatggcta ttcaagcccc 1680
agcatgagac cagatgtaag ctctcctcca tccagctcct caacagcaac aacaggacca 1740
cctcccaaac tctgcctggt gtgctctgat gaagcttcag gatgtcatta tggagtctta 1800
acttgtggaa gctgtaaagt tttcttcaaa agagcagtgg aaggacagca caattaccta 1860
tgtgctggaa ggaatgattg catcatcgat aaaattcgaa gaaaaaactg cccagcatgc 1920
cgctatcgaa aatgtcttca ggctggaatg aacctggaag ctcgaaaaac aaagaaaaaa 1980
ataaaaggaa ttcagcaggc cactacagga gtctcacaag aaacctctga aaatcctggt 2040
aacaaaacaa tagttcctgc aacgttacca caactcaccc ctaccctggt gtcactgttg 2100
gaggttattg aacctgaagt gttatatgca ggatatgata gctctgttcc agactcaact 2160
tggaggatca tgactacgct caacatgtta ggagggcggc aagtgattgc agcagtgaaa 2220
tgggcaaagg caataccagg tttcaggaac ttacacctgg atgaccaaat gaccctactg 2280
cagtactcct ggatgtttct tatggcattt gctctggggt ggagatcata tagacaatca 2340
agtgcaaacc tgctgtgttt tgctcctgat ctgattatta atgagcagag aatgactcta 2400
ccctgcatgt acgaccaatg taaacacatg ctgtatgttt cctctgagtt acacaggctt 2460
caggtatctt atgaagagta tctctgtatg aaaaccttac tgcttctctc ttcagttcct 2520
aaggacggtc tgaagagcca agagctattt gatgaaatta gaatgaccta catcaaagag 2580
ctaggaaaag ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat 2640
caactgacaa aactcttgga ttctatgcat gaaaatgtta tgtggttaaa accagaaagc 2700
acatctcaca cattaatctg attttcatcc caacaatctt ggcgctcaaa aaatagaact 2760
caatgagaaa aagaagatta tgtgcacttc gttgtcaata ataagtcaac tgatgctcat 2820
cgacaactat aggaggcttt tcattaaatg ggaaaagaag ctgtgccctt ttaggatacg 2880
tgggggaaaa gaaagtcatc ttaattatgt ttaattgtgg atttaagtgc tatatggtgg 2940
tgctgtttga aagcagattt atttcctatg tatgtgttat ctggccatcc caacccaaac 3000
tgttgaagtt tgtagtaact tcagtgagag ttggttactc acaacaaatc ctgaaaagta 3060
tttttagtgt ttgtaggtat tctgtgggat actatacaag cagaactgag gcacttagga 3120
cataacactt ttggggtata tatatccaaa tgcctaaaac tatgggagga aaccttggcc 3180
accccaaaag gaaaactaac atgatttgtg tctatgaagt gctggataat tagcatggga 3240
tgagctctgg gcatgccatg aaggaaagcc acgctccctt cagaattcag aggcagggag 3300
caattccagt ttcacctaag tctcataatt ttagttccct tttaaaaacc ctgaaaacta 3360
catcaccatg gaatgaaaaa tattgttata caatacattg atctgtcaaa cttccagaac 3420
catggtagcc ttcagtgaga tttccatctt ggctggtcac tccctgactg tagctgtagg 3480
tgaatgtgtt tttgtgtgtg tgtgtctggt tttagtgtca gaagggaaat aaaagtgtaa 3540
ggaggacact ttaaaccctt tgggtggagt ttcgtaattt cccagactat tttcaagcaa 3600
cctggtccac ccaggattag tgaccaggtt ttcaggaaag gatttgcttc tctctagaaa 3660
atgtctgaaa ggattttatt ttctgatgaa aggctgtatg aaaataccct cctcaaataa 3720
cttgcttaac tacatataga ttcaagtgtg tcaatattct attttgtata ttaaatgcta 3780
tataatgggg acaaatctat attatactgt gtatggcatt attaagaagc tttttcatta 3840
ttttttatca cagtaatttt aaaatgtgta aaaattaaaa ccagtgactc ctgtttaaaa 3900
ataaaagttg tagtttttta ttcatgctga ataataatct gtagttaaaa aaaaagtgtc 3960
tttttaccta cgcagtgaaa tgtcagactg taaaaccttg tgtggaaatg tttaactttt 4020
attttttcat ttaaatttgc tgttctggta ttaccaaacc acacatttgt accgaattgg 4080
cagtaaatgt tagccattta cagcaatgcc aaatatggag aaacatcata ataaaaaaat 4140
ctgctttttc atta                                                   4154

<210> 4
<211> 38
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 4
gggttctgct ttgcaacttc gccactcacg cagctcag                         38

<210> 5
<211> 39
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 5
cctttttcct ggggagttgg ttaagagggc caccgagtt                        39

<210> 6
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 6
ccattgtcaa gagggaagga a                                           21

<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 7
tgtttggaag caatagttaa ggag                                        24

<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 8
agaactggca gcggttttat c                                           21

<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 9
gtgtgagatg tgctttctgg ttt                                         23

<210> 10
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 10
cccagcacaa tgaagatcaa                                             20

<210> 11
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 11
acatctgctg gaaggtggac                                             20

<210> 12
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 12
atgttcgtca tgggtgtgaa                                             20

<210> 13
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 13
ggtgctaagc agttggtggt                                             20

<210> 14
<211> 119
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 14
ccattgtcaa gagggaagga aactccagcc agaactggca gcggttttat caactgacaa 60
aactcttgga ttctatgcat gaagtggttg aaaatctcct taactattgc ttccaaaca  119

<210> 15
<211> 91
<212> DNA
<213> Artificial Sequence

<220> 
<223> Homo Sapiens

<400> 15
agaactggca gcggttttat caactgacaa aactcttgga ttctatgcat gaaaatgtta 60
tgtggttaaa accagaaagc acatctcaca c                                91
