                         SEQUENCE LISTING

<110>  PhaseBio Pharmaceuticals, Inc.
       Jowett, James
       Woods, Christopher
 
<120>  THERAPEUTIC AGENTS COMPRISING INSULIN AMINO ACID SEQUENCES

<130>  PHAS-025/01WO 309646-2127

<150>  US 61/563,985
<151>  2011-11-28

<160>  34    

<170>  PatentIn version 3.5

<210>  1
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  1

Val Pro Gly Gly 
1               


<210>  2
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  2

Ile Pro Gly Gly 
1               


<210>  3
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  3

Val Pro Gly Xaa Gly 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  4

Ala Val Gly Val Pro 
1               5   


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  5

Ile Pro Gly Xaa Gly 
1               5   


<210>  6
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  6

Ile Pro Gly Val Gly 
1               5   


<210>  7
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring or non-natural amino acid

<400>  7

Leu Pro Gly Xaa Gly 
1               5   


<210>  8
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  8

Leu Pro Gly Val Gly 
1               5   


<210>  9
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  9

Val Ala Pro Gly Val Gly 
1               5       


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  10

Gly Val Gly Val Pro Gly Val Gly 
1               5               


<210>  11
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  11

Val Pro Gly Phe Gly Val Gly Ala Gly 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP component sequence

<400>  12

Val Pro Gly Val Gly Val Pro Gly Gly 
1               5                   


<210>  13
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  13

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  14
<211>  691
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP-1-120 fusion protein

<400>  14

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn Val Pro Gly Val Gly Val Pro Gly Val Gly 
                85                  90                  95      


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
            100                 105                 110         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        115                 120                 125             


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
    130                 135                 140                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
145                 150                 155                 160 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                165                 170                 175     


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
            180                 185                 190         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        195                 200                 205             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    210                 215                 220                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
225                 230                 235                 240 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                245                 250                 255     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            260                 265                 270         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
        275                 280                 285             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly 
    290                 295                 300                 


Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val 
305                 310                 315                 320 


Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly 
                325                 330                 335     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val 
            340                 345                 350         


Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        355                 360                 365             


Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly 
    370                 375                 380                 


Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly 
385                 390                 395                 400 


Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                405                 410                 415     


Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val 
            420                 425                 430         


Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro 
        435                 440                 445             


Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val Pro Gly 
    450                 455                 460                 


Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala 
465                 470                 475                 480 


Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly Val Gly 
                485                 490                 495     


Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val Gly Val 
            500                 505                 510         


Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro 
        515                 520                 525             


Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val Pro Gly 
    530                 535                 540                 


Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Val 
545                 550                 555                 560 


Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly 
                565                 570                 575     


Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val Gly Val 
            580                 585                 590         


Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro 
        595                 600                 605             


Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly 
    610                 615                 620                 


Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro Gly Val 
625                 630                 635                 640 


Gly Val Pro Gly Val Gly Val Pro Gly Gly Gly Val Pro Gly Ala Gly 
                645                 650                 655     


Val Pro Gly Val Gly Val Pro Gly Val Gly Val Pro Gly Val Gly Val 
            660                 665                 670         


Pro Gly Gly Gly Val Pro Gly Ala Gly Val Pro Gly Gly Gly Val Pro 
        675                 680                 685             


Gly Trp Pro 
    690     


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ile Val Glu Gln Cys Cys Ala Ser Val Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  16
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  16

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Ala 
            20                  25                  30  


<210>  17
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide

<400>  17

Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
1               5                   10          


<210>  18
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide

<400>  18

Gly Ala Gly Ser Ser Ser Arg Arg Ala Pro Gln Thr 
1               5                   10          


<210>  19
<211>  261
<212>  DNA
<213>  Homo sapiens

<400>  19
atgtttgtga accaacacct gtgcggctca cacctggtgg aagctctcta cctagtgtgc       60

ggggaacgag gcttcttcta cacacccaag acccgccggg aggcagagga cctgcaggtg      120

gggcaggtgg agctgggcgg gggccctggt gcaggcagcc tgcagccctt ggccctggag      180

gggtccctgc agaagcgtgg cattgtggaa caatgctgta ccagcatctg ctccctctac      240

cagctggaga actactgcaa c                                                261


<210>  20
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu 
1               5                   10                  15      


Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg 
            20                  25                  30          


Arg Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly 
        35                  40                  45              


Pro Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln 
    50                  55                  60                  


Lys Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr 
65                  70                  75                  80  


Gln Leu Glu Asn Tyr Cys Asn 
                85          


<210>  21
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Linker peptide

<400>  21

Gly Phe Leu Gly 
1               


<210>  22
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  22

His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 
1               5                   10                  15      


Ser Ser Tyr Leu Glu Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu 
            20                  25                  30          


Val Lys Gly Arg Gly 
        35          


<210>  23
<211>  87
<212>  PRT
<213>  Heloderma suspectum

<400>  23

Met Lys Ile Ile Leu Trp Leu Cys Val Phe Gly Leu Phe Leu Ala Thr 
1               5                   10                  15      


Leu Phe Pro Ile Ser Trp Gln Met Pro Val Glu Ser Gly Leu Ser Ser 
            20                  25                  30          


Glu Asp Ser Ala Ser Ser Glu Ser Phe Ala Ser Lys Ile Lys Arg His 
        35                  40                  45              


Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu Glu 
    50                  55                  60                  


Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser Ser 
65                  70                  75                  80  


Gly Ala Pro Pro Pro Ser Gly 
                85          


<210>  24
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  24

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  25
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  25

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  26
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  26

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  27
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Val Ala Thr Lys Thr Phe Ala Leu Leu Leu Leu Ser Leu Phe Leu 
1               5                   10                  15      


Ala Val Gly Leu Gly Glu Lys Lys Glu Gly His Phe Ser Ala Leu Pro 
            20                  25                  30          


Ser Leu Pro Val Gly Ser His Ala Lys Val Ser Ser Pro Gln Pro Arg 
        35                  40                  45              


Gly Pro Arg Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala 
    50                  55                  60                  


Met Asp Lys Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
65                  70                  75                  80  


Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln Arg Glu Ala 
                85                  90                  95      


Arg Ala Leu Glu Leu Ala Ser Gln Ala Asn Arg Lys Glu Glu Glu Ala 
            100                 105                 110         


Val Glu Pro Gln Ser Ser Pro Ala Lys Asn Pro Ser Asp Glu Asp Leu 
        115                 120                 125             


Leu Arg Asp Leu Leu Ile Gln Glu Leu Leu Ala Cys Leu Leu Asp Gln 
    130                 135                 140                 


Thr Asn Leu Cys Arg Leu Arg Ser Arg 
145                 150             


<210>  28
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys Ser Ile Tyr Phe Val Ala Gly Leu Phe Val Met Leu Val Gln 
1               5                   10                  15      


Gly Ser Trp Gln Arg Ser Leu Gln Asp Thr Glu Glu Lys Ser Arg Ser 
            20                  25                  30          


Phe Ser Ala Ser Gln Ala Asp Pro Leu Ser Asp Pro Asp Gln Met Asn 
        35                  40                  45              


Glu Asp Lys Arg His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys 
    50                  55                  60                  


Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn 
65                  70                  75                  80  


Thr Lys Arg Asn Arg Asn Asn Ile Ala Lys Arg His Asp Glu Phe Glu 
                85                  90                  95      


Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 
            100                 105                 110         


Gly Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
        115                 120                 125             


Arg Arg Asp Phe Pro Glu Glu Val Ala Ile Val Glu Glu Leu Gly Arg 
    130                 135                 140                 


Arg His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp 
145                 150                 155                 160 


Asn Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile 
                165                 170                 175     


Thr Asp Arg Lys 
            180 


<210>  29
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  29

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  30
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP biopolymer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(300)
<223>  Xaa may be any natural or non-natural amino acid residue

<400>  30

Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
1               5                   10                  15      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            20                  25                  30          


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        35                  40                  45              


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    50                  55                  60                  


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
65                  70                  75                  80  


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                85                  90                  95      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            100                 105                 110         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        115                 120                 125             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    130                 135                 140                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
145                 150                 155                 160 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                165                 170                 175     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            180                 185                 190         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        195                 200                 205             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    210                 215                 220                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
225                 230                 235                 240 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                245                 250                 255     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            260                 265                 270         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        275                 280                 285             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
    290                 295                 300 


<210>  31
<211>  450
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP biopolymer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(450)
<223>  Xaa may be any natural or non-natural amino acid residue

<400>  31

Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
1               5                   10                  15      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            20                  25                  30          


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        35                  40                  45              


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    50                  55                  60                  


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
65                  70                  75                  80  


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                85                  90                  95      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            100                 105                 110         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        115                 120                 125             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    130                 135                 140                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
145                 150                 155                 160 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                165                 170                 175     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            180                 185                 190         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        195                 200                 205             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    210                 215                 220                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
225                 230                 235                 240 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                245                 250                 255     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            260                 265                 270         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        275                 280                 285             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    290                 295                 300                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
305                 310                 315                 320 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                325                 330                 335     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            340                 345                 350         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        355                 360                 365             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    370                 375                 380                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
385                 390                 395                 400 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                405                 410                 415     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            420                 425                 430         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        435                 440                 445             


Xaa Gly 
    450 


<210>  32
<211>  600
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP biopolymer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(600)
<223>  Xaa may be any natural or non-natural amino acid residue

<400>  32

Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
1               5                   10                  15      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            20                  25                  30          


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        35                  40                  45              


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    50                  55                  60                  


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
65                  70                  75                  80  


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                85                  90                  95      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            100                 105                 110         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        115                 120                 125             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    130                 135                 140                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
145                 150                 155                 160 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                165                 170                 175     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            180                 185                 190         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        195                 200                 205             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    210                 215                 220                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
225                 230                 235                 240 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                245                 250                 255     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            260                 265                 270         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        275                 280                 285             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    290                 295                 300                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
305                 310                 315                 320 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                325                 330                 335     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            340                 345                 350         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        355                 360                 365             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    370                 375                 380                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
385                 390                 395                 400 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                405                 410                 415     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            420                 425                 430         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        435                 440                 445             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    450                 455                 460                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
465                 470                 475                 480 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                485                 490                 495     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            500                 505                 510         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        515                 520                 525             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    530                 535                 540                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
545                 550                 555                 560 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                565                 570                 575     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            580                 585                 590         


Gly Xaa Gly Val Pro Gly Xaa Gly 
        595                 600 


<210>  33
<211>  900
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  ELP biopolymer sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(900)
<223>  Xaa may be any natural or non-natural amino acid residue

<400>  33

Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
1               5                   10                  15      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            20                  25                  30          


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        35                  40                  45              


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    50                  55                  60                  


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
65                  70                  75                  80  


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                85                  90                  95      


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            100                 105                 110         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        115                 120                 125             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    130                 135                 140                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
145                 150                 155                 160 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                165                 170                 175     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            180                 185                 190         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        195                 200                 205             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    210                 215                 220                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
225                 230                 235                 240 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                245                 250                 255     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            260                 265                 270         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        275                 280                 285             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    290                 295                 300                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
305                 310                 315                 320 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                325                 330                 335     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            340                 345                 350         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        355                 360                 365             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    370                 375                 380                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
385                 390                 395                 400 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                405                 410                 415     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            420                 425                 430         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        435                 440                 445             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    450                 455                 460                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
465                 470                 475                 480 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                485                 490                 495     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            500                 505                 510         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        515                 520                 525             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    530                 535                 540                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
545                 550                 555                 560 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                565                 570                 575     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            580                 585                 590         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        595                 600                 605             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    610                 615                 620                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
625                 630                 635                 640 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                645                 650                 655     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            660                 665                 670         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        675                 680                 685             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    690                 695                 700                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
705                 710                 715                 720 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                725                 730                 735     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            740                 745                 750         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        755                 760                 765             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    770                 775                 780                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
785                 790                 795                 800 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                805                 810                 815     


Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro 
            820                 825                 830         


Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly 
        835                 840                 845             


Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa 
    850                 855                 860                 


Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly 
865                 870                 875                 880 


Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val Pro Gly Xaa Gly Val 
                885                 890                 895     


Pro Gly Xaa Gly 
            900 


<210>  34
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  non-cleavable spacer peptide


<220>
<221>  REPEAT
<222>  (1)..(20)
<223>  Gly residues in Gy Gly Gly Gly Ser subsequence may be repeated 1 
       to 4 times

<220>
<221>  REPEAT
<222>  (1)..(20)
<223>  Gy Gly Gly Gly Ser subsequence may be repeated 1 to 4 times

<400>  34

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


