                               SEQUENCE LISTING

<110> THE GENERAL HOSPITAL CORPORATION
 
<120> DIFFERENTIATION OF BROWN ADIPOCYTES

<130> 030258-071751-PCT

<140>
<141>

<150> 61/566,278
<151> 2011-12-02

<160> 53    

<170> PatentIn version 3.5

<210> 1
<211> 1820
<212> DNA
<213> Homo sapiens

<400> 1
ttcaagtctt tttcttttaa cggattgatc ttttgctaga tagagacaaa atatcagtgt       60

gaattacagc aaacccctat tccatgctgt tatgggtgaa actctgggag attctcctat      120

tgacccagaa agcgattcct tcactgatac actgtctgca aacatatcac aagaaatgac      180

catggttgac acagagatgc cattctggcc caccaacttt gggatcagct ccgtggatct      240

ctccgtaatg gaagaccact cccactcctt tgatatcaag cccttcacta ctgttgactt      300

ctccagcatt tctactccac attacgaaga cattccattc acaagaacag atccagtggt      360

tgcagattac aagtatgacc tgaaacttca agagtaccaa agtgcaatca aagtggagcc      420

tgcatctcca ccttattatt ctgagaagac tcagctctac aataagcctc atgaagagcc      480

ttccaactcc ctcatggcaa ttgaatgtcg tgtctgtgga gataaagctt ctggatttca      540

ctatggagtt catgcttgtg aaggatgcaa gggtttcttc cggagaacaa tcagattgaa      600

gcttatctat gacagatgtg atcttaactg tcggatccac aaaaaaagta gaaataaatg      660

tcagtactgt cggtttcaga aatgccttgc agtggggatg tctcataatg ccatcaggtt      720

tgggcggatg ccacaggccg agaaggagaa gctgttggcg gagatctcca gtgatatcga      780

ccagctgaat ccagagtccg ctgacctccg ggccctggca aaacatttgt atgactcata      840

cataaagtcc ttcccgctga ccaaagcaaa ggcgagggcg atcttgacag gaaagacaac      900

agacaaatca ccattcgtta tctatgacat gaattcctta atgatgggag aagataaaat      960

caagttcaaa cacatcaccc ccctgcagga gcagagcaaa gaggtggcca tccgcatctt     1020

tcagggctgc cagtttcgct ccgtggaggc tgtgcaggag atcacagagt atgccaaaag     1080

cattcctggt tttgtaaatc ttgacttgaa cgaccaagta actctcctca aatatggagt     1140

ccacgagatc atttacacaa tgctggcctc cttgatgaat aaagatgggg ttctcatatc     1200

cgagggccaa ggcttcatga caagggagtt tctaaagagc ctgcgaaagc cttttggtga     1260

ctttatggag cccaagtttg agtttgctgt gaagttcaat gcactggaat tagatgacag     1320

cgacttggca atatttattg ctgtcattat tctcagtgga gaccgcccag gtttgctgaa     1380

tgtgaagccc attgaagaca ttcaagacaa cctgctacaa gccctggagc tccagctgaa     1440

gctgaaccac cctgagtcct cacagctgtt tgccaagctg ctccagaaaa tgacagacct     1500

cagacagatt gtcacggaac acgtgcagct actgcaggtg atcaagaaga cggagacaga     1560

catgagtctt cacccgctcc tgcaggagat ctacaaggac ttgtactagc agagagtcct     1620

gagccactgc caacatttcc cttcttccag ttgcactatt ctgagggaaa atctgacacc     1680

taagaaattt actgtgaaaa agcattttaa aaagaaaagg ttttagaata tgatctattt     1740

tatgcatatt gtttataaag acacatttac aatttacttt taatattaaa aattaccata     1800

ttatgaaatt gctgatagta                                                 1820


<210> 2
<211> 505
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Glu Thr Leu Gly Asp Ser Pro Ile Asp Pro Glu Ser Asp Ser 
1               5                   10                  15      


Phe Thr Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu Met Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210> 3
<211> 1837
<212> DNA
<213> Homo sapiens

<400> 3
gagccgcgca cgggactggg aaggggaccc acccgagggt ccagccacca gccccctcac       60

taatagcggc caccccggca gcggcggcag cagcagcagc gacgcagcgg cgacagctca      120

gagcagggag gccgcgccac ctgcgggccg gccggagcgg gcagccccag gccccctccc      180

cgggcacccg cgttcatgca acgcctggtg gcctgggacc cagcatgtct ccccctgccg      240

ccgccgccgc ctgcctttaa atccatggaa gtggccaact tctactacga ggcggactgc      300

ttggctgctg cgtacggcgg caaggcggcc cccgcggcgc cccccgcggc cagacccggg      360

ccgcgccccc ccgccggcga gctgggcagc atcggcgacc acgagcgcgc catcgacttc      420

agcccgtacc tggagccgct gggcgcgccg caggccccgg cgcccgccac ggccacggac      480

accttcgagg cggctccgcc cgcgcccgcc cccgcgcccg cctcctccgg gcagcaccac      540

gacttcctct ccgacctctt ctccgacgac tacgggggca agaactgcaa gaagccggcc      600

gagtacggct acgtgagcct ggggcgcctg ggggccgcca agggcgcgct gcaccccggc      660

tgcttcgcgc ccctgcaccc accgcccccg ccgccgccgc cgcccgccga gctcaaggcg      720

gagccgggct tcgagcccgc ggactgcaag cggaaggagg aggccggggc gccgggcggc      780

ggcgcaggca tggcggcggg cttcccgtac gcgctgcgcg cttacctcgg ctaccaggcg      840

gtgccgagcg gcagcagcgg gagcctctcc acgtcctcct cgtccagccc gcccggcacg      900

ccgagccccg ctgacgccaa ggcgcccccg accgcctgct acgcgggggc cgcgccggcg      960

ccctcgcagg tcaagagcaa ggccaagaag accgtggaca agcacagcga cgagtacaag     1020

atccggcgcg agcgcaacaa catcgccgtg cgcaagagcc gcgacaaggc caagatgcgc     1080

aacctggaga cgcagcacaa ggtcctggag ctcacggccg agaacgagcg gctgcagaag     1140

aaggtggagc agctgtcgcg cgagctcagc accctgcgga acttgttcaa gcagctgccc     1200

gagcccctgc tcgcctcctc cggccactgc tagcgcggcc cccgcgcgcg tccccctgcc     1260

ggccggggct gagactccgg ggagcgcccg cgcccgcgcc ctcgcccccg cccccggcgg     1320

cgccggcaaa actttggcac tggggcactt ggcagcgcgg ggagcccgtc ggtaatttta     1380

atattttatt atatatatat atctatattt ttgtccaaac caaccgcaca tgcagatggg     1440

gctcccgccc gtggtgttat ttaaagaaga aacgtctatg tgtacagatg aatgataaac     1500

tctctgcttc tccctctgcc cctctccagg cgccggcggg cgggccggtt tcgaagttga     1560

tgcaatcggt ttaaacatgg ctgaacgcgt gtgtacacgg gactgacgca acccacgtgt     1620

aactgtcagc cgggccctga gtaatcgctt aaagatgttc ctacgggctt gttgctgttg     1680

atgttttgtt ttgttttgtt ttttggtctt tttttgtatt ataaaaaata atctatttct     1740

atgagaaaag aggcgtctgt atattttggg aatcttttcc gtttcaagca ttaagaacac     1800

ttttaataaa cttttttttg agaatggtta caaagcc                              1837


<210> 4
<211> 345
<212> PRT
<213> Homo sapiens

<400> 4
Met Gln Arg Leu Val Ala Trp Asp Pro Ala Cys Leu Pro Leu Pro Pro 
1               5                   10                  15      


Pro Pro Pro Ala Phe Lys Ser Met Glu Val Ala Asn Phe Tyr Tyr Glu 
            20                  25                  30          


Ala Asp Cys Leu Ala Ala Ala Tyr Gly Gly Lys Ala Ala Pro Ala Ala 
        35                  40                  45              


Pro Pro Ala Ala Arg Pro Gly Pro Arg Pro Pro Ala Gly Glu Leu Gly 
    50                  55                  60                  


Ser Ile Gly Asp His Glu Arg Ala Ile Asp Phe Ser Pro Tyr Leu Glu 
65                  70                  75                  80  


Pro Leu Gly Ala Pro Gln Ala Pro Ala Pro Ala Thr Ala Thr Asp Thr 
                85                  90                  95      


Phe Glu Ala Ala Pro Pro Ala Pro Ala Pro Ala Pro Ala Ser Ser Gly 
            100                 105                 110         


Gln His His Asp Phe Leu Ser Asp Leu Phe Ser Asp Asp Tyr Gly Gly 
        115                 120                 125             


Lys Asn Cys Lys Lys Pro Ala Glu Tyr Gly Tyr Val Ser Leu Gly Arg 
    130                 135                 140                 


Leu Gly Ala Ala Lys Gly Ala Leu His Pro Gly Cys Phe Ala Pro Leu 
145                 150                 155                 160 


His Pro Pro Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Lys Ala Glu 
                165                 170                 175     


Pro Gly Phe Glu Pro Ala Asp Cys Lys Arg Lys Glu Glu Ala Gly Ala 
            180                 185                 190         


Pro Gly Gly Gly Ala Gly Met Ala Ala Gly Phe Pro Tyr Ala Leu Arg 
        195                 200                 205             


Ala Tyr Leu Gly Tyr Gln Ala Val Pro Ser Gly Ser Ser Gly Ser Leu 
    210                 215                 220                 


Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala Asp 
225                 230                 235                 240 


Ala Lys Ala Pro Pro Thr Ala Cys Tyr Ala Gly Ala Ala Pro Ala Pro 
                245                 250                 255     


Ser Gln Val Lys Ser Lys Ala Lys Lys Thr Val Asp Lys His Ser Asp 
            260                 265                 270         


Glu Tyr Lys Ile Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
        275                 280                 285             


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
    290                 295                 300                 


Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
305                 310                 315                 320 


Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
                325                 330                 335     


Pro Leu Leu Ala Ser Ser Gly His Cys 
            340                 345 


<210> 5
<211> 8738
<212> DNA
<213> Homo sapiens

<400> 5
ctgacaatgc tggggagatg aagatagtgt gtggctgctt ctggactcaa ggaggaggag       60

agagattccg cgagccgaca ccatgcgatc caaggcgagg gcgaggaagc tagccaaaag      120

tgacggtgac gttgtaaata atatgtatga gcccaaccgg gacctgctgg ccagccacag      180

cgcggaggac gaggccgagg acagtgccat gtcgcccatc cccgtggggc caccgtcccc      240

cttccccacc agcgaggact tcacccccaa ggagggctcg ccgtacgagg cccctgtcta      300

cattcctgaa gacattccga tcccagcaga cttcgagctc cgagagtcct ccatcccagg      360

ggctggcctg ggggtctggg ccaagaggaa gatggaagcc ggggagaggc tgggcccctg      420

cgtggtggtg ccccgggcgg cggcaaagga gacagacttc ggatgggagc aaatactgac      480

ggacgtggaa gtgtcgcccc aggaaggctg catcacaaag atctccgaag acctgggcag      540

tgagaagttc tgcgtggatg caaatcaggc gggggctggc agctggctca agtacatccg      600

tgtggcgtgc tcctgcgatg accagaacct caccatgtgt cagatcagtg agcagattta      660

ctataaagtc attaaggaca ttgagccagg tgaggagctg ctggtgcacg tgaaggaagg      720

cgtctacccc ctgggcacag tgccgcccgg cctggacgag gagcccacgt tccgctgtga      780

cgagtgtgac gaactcttcc agtccaagct ggacctgcgg cgccataaga agtacacgtg      840

tggctcagtg ggggctgcgc tctacgaggg cctggctgag gagctcaagc ccgagggcct      900

tggcggtggc agcggccaag cccacgagtg caaggactgc gagcggatgt tccccaacaa      960

gtacagcctg gagcagcaca tggtcatcca cacggaggag cgcgagtaca aatgcgacca     1020

gtgtcccaag gccttcaact ggaagtccaa cctcatccgc caccagatgt cccacgacag     1080

cggcaaacgc ttcgaatgtg aaaactgcgt gaaggtgttc acggacccca gcaaccttca     1140

gcggcacatc cgctcgcagc acgtgggcgc tcgggcccac gcctgccccg actgcgggaa     1200

gaccttcgcc acgtcctccg gcctcaagca gcacaagcat atccacagca cggtgaagcc     1260

tttcatatgt gaggtctgcc acaagtccta cacgcagttc tccaacctgt gccggcacaa     1320

gcggatgcac gccgactgcc gcacgcagat caagtgcaag gactgtggcc agatgttcag     1380

cactacctcc tccctcaaca agcaccggcg cttctgcgag ggcaagaacc attacacgcc     1440

gggcggcatc tttgccccgg gcctgccctt gacccccagc cccatgatgg acaaggcaaa     1500

accctccccc agcctcaatc acgccagcct gggcttcaac gagtactttc cctccaggcc     1560

gcacccgggg agcctgccct tctccacggc gcctcccacg ttccccgcac tcacccccgg     1620

cttcccgggc atcttccctc catccttgta cccccggccg cctctgctac ctcccacatc     1680

gctgctcaag agccccctga accacaccca ggacgccaag ctccccagtc ccctggggaa     1740

cccagccctg cccctggtct ccgccgtcag caacagcagc cagggcacga cggcagctgc     1800

ggggcccgag gagaagttcg agagccgcct ggaggactcc tgtgtggaga agctgaagac     1860

caggagcagc gacatgtcgg acggcagtga ctttgaggac gtcaacacca ccacggggac     1920

cgacctggac acgaccacgg ggacgggctc ggacctggac agcgacgtgg acagcgaccc     1980

tgacaaggac aagggcaagg gcaagtccgc cgagggccag cccaagtttg ggggcggctt     2040

ggcgcccccg ggggccccga acagcgtggc cgaggtgcct gtcttctatt cccagcactc     2100

attcttcccg ccacccgacg agcagctgct gactgcaacg ggcgccgccg gggactccat     2160

caaggccatc gcatccattg ccgagaagta ctttggcccc ggcttcatgg ggatgcagga     2220

gaagaagctg ggctcgctcc cctaccactc ggcgttcccc ttccagttcc tgcccaactt     2280

cccccactcc ctttacccct tcacggaccg agccctcgcc cacaacttgc tggtcaaggc     2340

cgagccaaag tcaccccggg acgccctcaa ggtgggcggc cccagtgccg agtgcccctt     2400

tgatctcacc accaagccca aagacgtgaa gcccatcctg cccatgccca agggcccctc     2460

ggcccccgca tccggcgagg agcagccgct ggacctgagc atcggcagcc gggcccgtgc     2520

cagccaaaac ggcggcgggc gggagccccg caagaaccac gtctatgggg aacgcaagct     2580

gggcgccggc gaggggctgc cccaggtgtg cccggcgcgg atgccccagc agcccccgct     2640

ccactacgcc aagccctcgc ccttcttcat ggaccccatc tacagcaggg tagaaaagcg     2700

gaaggtcaca gaccccgtgg gagccctgaa ggagaagtac ctgcggccgt ccccgctgct     2760

cttccacccc cagatgtcag ccatagagac catgacagag aagctggaga gctttgcagc     2820

catgaaggcg gactcgggca gctccctgca gcccctcccc caccacccct tcaacttccg     2880

gtccccaccc ccaacgctct ccgaccccat cctcaggaag ggcaaggagc gatacacgtg     2940

caggtactgt gggaagatct tccccagatc agccaatctc accagacacc tgaggacgca     3000

cactggggag cagccgtaca ggtgtaagta ctgcgaccgc tccttcagca tctcttcgaa     3060

cctccagcgg cacgtccgga acatccacaa caaggagaag cctttcaagt gccacctgtg     3120

caaccgctgc ttcgggcagc agaccaacct ggaccggcac ctcaagaagc acgagcacga     3180

gaacgcacca gtgagccagc accccggggt cctcacgaac cacctgggga ccagcgcgtc     3240

ctctcccacc tcagagtcgg acaaccacgc acttttagac gagaaagaag actcttattt     3300

ctcggaaatc agaaacttta ttgccaatag tgagatgaac caagcatcaa cgcgaacaga     3360

gaaacgggcg gacatgcaga tcgtggacgg cagtgcccag tgtccaggcc tagccagtga     3420

gaagcaggag gacgtggagg aggaggacga cgatgacctg gaggaggacg atgaggacag     3480

cctggccggg aagtcgcagg atgacaccgt gtcccccgca cccgagcccc aggccgccta     3540

cgaggatgag gaggatgagg agccagccgc ctccctggcc gtgggctttg accacacccg     3600

aaggtgtgct gaggaccacg aaggcggtct gttagctttg gagccgatgc cgacttttgg     3660

gaaggggctg gacctccgca gagcagctga ggaagcattt gaagttaaag atgtgcttaa     3720

ttccacctta gattctgagg ctttaaaaca tacactgtgc aggcaggcta agaaccaggc     3780

atatgcaatg atgctgtccc tttccgaaga cactcctctc cacaccccct cccagggttc     3840

tctggacgct tggttgaagg tcactggagc cacgtcggag tctggagcat ttcaccccat     3900

caaccacctc tgacgggctg ggcagccggg ggccggtggc cagagcgagg gcaccagcca     3960

cgaaggacgg aggcgggcgg ggccccggag aaccctgtcc ctgcgtgtgg ccactcctca     4020

gcatcctccc cacccaccat ggttcattcc gacttttcca atggaaactc agatcccaaa     4080

agtccctaaa gcagtcgtag agtctcacca tctccaagga ttggtcttga gaacactgtt     4140

cagtgacggc catgcaggtg gccgtccaaa gacagccaac ggagctgcct cgcagaatca     4200

gccagtgggc aggtggacgc tctgctgaga cagaagctgg tggccactgc cgggtgcccg     4260

cgtggggtcg cggaagggaa tggatagact ggtgtgctca aaagagagag atcactcaaa     4320

tgatttttat aatgaaatga caagaataac ccttttggta accgtattga ctgcagagtc     4380

tatttaagca tgtggtttta aaaatagaca gtatttttta aaaatcaaaa aatgacttgc     4440

aaattgtttt ttaaaagtaa ttttgcattg ctttgaaatt tgagctcatt tgcaaacccg     4500

agtctgcctg ggaacccgca ctgtgcctgg gtgtattctt tatactgtag ataatggaga     4560

aattttctat ctctgtccct atttgtataa gccaaggtga tgctgggtgc cccgaggcag     4620

aacaagaggc gcggggccac acccgtgaac catgcagacg gccgaagaag tcttaggcag     4680

ggcgccctgg gctgcaggcc tgcccgaggc tgggatggga agtgtgcctg ccctcgtgtg     4740

acatggaatt ggtgtcagga ccgccacgtg gccttcagag gaatccacag gtccccaccc     4800

aagatccctc aattatatgg ggaagtcgag ggcctgtggc ttggatccgc catgcagaga     4860

tgtggccggg cacccatctt ccttccctcc tctgtccctg cctcggccac cccacgcggg     4920

aacccagcgc cgtcctctga aggcagggcc ttggccacgt cctgggtctc ccacctccca     4980

cctgacccca gcggctccgg tgtcctccac gtggctgccc tggggagcaa tcccagcgga     5040

tcgctccggg ccaccaagcc gcacctgtgc ctgagactcc ggatggacga cacagtcgtc     5100

acgtcgctct tcctgcgggt tcttggcgag acacagcttg agaacagaag ggcgtcgggg     5160

gaacctgccg caaggagcag agacagcaca gccccccggg cccagccgcc tccctctctt     5220

gggacgcaac ttcttcccca ctcggatggg ctttaaatta ttcccatagg ggccaatttc     5280

aaataataat ttttttccct gatggaattt accttaatct gtatataact tgtaattttt     5340

tctaattcat ttcttttctt attttatttc ctccttaaca gtatttttgg cattagacat     5400

tcttattgtg aagaaataat gttaatataa gtatctggtg aaggaccaaa accgtgtgat     5460

aaggttgtgt gtcgtgtggg agtggggcga ttttttatgt gccaaatacc cccgtccccc     5520

ccatgaatcc tgctgtccct gctgccgttt accagacaat catatgtttt tgttaaattt     5580

gcgtttcagt tacatttgca tttaagacaa gtgttctatt tatttcttgt attgtttgga     5640

agaaaaaatg atgatagagt cccaaaaaga agagaaaaaa aatgcccaag ttgcccttta     5700

aaaaaaaaga gcgtaaatac aaacaggagt ggtgcaagcc gccttggtgt gggtttgtgt     5760

cacgtgtgga catctcctca ggctttgtgt cacgcgtgga catctcctca ggctgtcccc     5820

agcggtgacg ggaggtgtcc tggctgctcc aggacaaaag acaatcgtct ctgtgggtgc     5880

cgggtggtcc aggcttgcac tgaagacgtg ccacggggag gctcctgcag gaggctcaac     5940

ccgacggatc acagtgaaag ggattcctcc cacgccagat ctgcacaacg aggcaagaca     6000

ggacccacct gtgcgtgcgc tggggccatg gggtggcccc gccggggcag cgggggagct     6060

gcctgcagaa gagccagctg gcgtgtcggg aaggatccag gatctgcaaa cacaactgct     6120

caggccttct cacgcgtttc cacaacatcc cctgggtcag acccaccagg taccccgtag     6180

gaatttccag tttcccttga tctagatggg attcttataa aaattcaacc tcagacataa     6240

acaccccatt tctgtaaacc caaattatat ggtttcttct gcgaaagagt aaggtgtgtg     6300

cttttttttt tttgcaatat gaccccgtct ctctgaagtg ggacattcgg acggatggag     6360

ccctcagcgt gtcttttcag caggagcaga accgatgaga gccgccctta ccgttggtct     6420

ccggatcccc cagtcccatc ccgccgtttt cggctgtctt cctaaccgtc ctgtcttctc     6480

ttggcgctct ttccttccac ctttcccaag agtcctggtt gcacgtttta agtcatatat     6540

tttcgtcccc ctgaaaatga tggcaagccc agtttctcct gagcattcag acccccaggc     6600

cccagcactt ggcgttttca ggaggccctg ttcttagagc ccctgacaaa ggcagcactt     6660

atttcctggg ctggtgcgcc ccaaaacacg gccccgacac ttagtgtggc cccaggcccc     6720

agcgagcctc gccctcccag ttttgctctg cccagcagtg ttggtgccca gagatgacaa     6780

gggccaggga gcctggcccg ggtgtgagaa ttcagagatt ctggcctcca gctgtcacca     6840

caccgtaacg gggccatgta actgtgcagc atggacaggg atgcgacggg gcagctggct     6900

gtgtccatgg ccaggtggcc agggtcaggg ctgcaagcca ggggtccagg gcccttccgt     6960

tcagcccaaa tgctgcccca atgctaactc cttggattgt caacccccat cccccaaatg     7020

gaaattccga aggaggcctc ctcgcacctg ccctccgctg ctcctcagac cccagccccc     7080

agcgagccga cgtccccacc cgttcctgct ctcatcccca ggttgggcac gtggggttcc     7140

tcctctgtgg gcctggcaga cccttcatga gtgggaccca agatatcact gacttcaacc     7200

cagaggatcg agcccctgca ccctgcctgg ggccctgggg tgtggagcag tggctggggt     7260

gggcgtggtg tggcctgaga gactgcccag ctggagaggc cttcctttac aaggccacgc     7320

gtgcagctgt cccatccaga ccccgactgg ccaagacctc cacgtcccca gagtccagcc     7380

ctggaaattc caagggccct ggcgtcctct gccttccccg cttccccatg agcgtctgca     7440

aaacacttgc ctgaatacat atcacgtatt ttagactcga agcctcaaag cactggattg     7500

tggtcccctg ccccctctgt cccgtccccc tgcccaagtg actgaaacct actgagctat     7560

attcactgtg ctgtcctagg gggagggaga gcagagctcg cccctgcact gcagccttgt     7620

gggggagggc aaggctctcc tcccagccag ggacgccagg acatagctgc tcctggtcag     7680

tggaggtcag ccgggtatca aaagccatga aactgtgtct ctgtagcaat gagtgatact     7740

gtgacaaaac catccttgca ttcttcctag aagagttcct ctgctccttc cattccattt     7800

ttgtgtttgt tttgttcttt tctgtcactg atccgtatta ccacttttgg aaaaaaataa     7860

ataaataaat aaataaaagg cagcttgagt ttccaaacgt gtgattcact tgtgaacaaa     7920

agtcattcta acaattgcct tcagcgtcac gtgcattgcc actgcgcttt cggcacgagg     7980

gatgctgagc cctggtgtca gagtcgtaat ttaaagcgtg tgtgtatatg gactttgtcc     8040

cttaaggtcg atataaagaa tcctcgcaga atcacagacc tgtgccgccc gccaccttct     8100

gccattgtta cattacagat ttggtttagt tttgttttgt tttgtttttt cttttagaac     8160

tgtatagtat tgaaaaagaa atcaaatgta aatgtctggt tttcatataa tgtttaaaaa     8220

gaccattgag aaggaggctg gcgctcgccc catgtccccc ttgattgtaa attgcttctg     8280

ttctgtttat aagtaaactg tgcatgactc ctgcttagcg gtcattatcg tgtctgttgg     8340

tgaaattttt attaaaagga aaattctgta gatgcactta ttgaatatgt gattaggatc     8400

tacgtctgag actaggagtc ctgaactgct gacgcgaaag aggcgcagtt cccaattaat     8460

acggaaatcg ctgtgggaga agaatgaaat aagacgtgaa gtgtaggaaa tcatgaaaag     8520

aacaattttg caaattgcat tctgatgctt gtgatgaaca caaatgtact tgtgtagaga     8580

catttcctta agagaaagcc taggagaagc cgatttggag gttaatgctg tagaatagga     8640

ctgtatacca aatgtaatct ttccaatgct ccaatgaatt tatacatgag attgatatgc     8700

aataaatctg tgtgcttttc taaaaaaaaa aaaaaaaa                             8738


<210> 6
<211> 8674
<212> DNA
<213> Homo sapiens

<400> 6
ctgacaatgc tggggagatg aagatagtgt gtggctgctt ctggactcaa ggaggaggag       60

agagattccg cgagccgaca ccatgcgatc caaggcgagg gcgaggaagc tagccaaaag      120

tgacggtgac gttgtaaata atatgtatga gcccaaccgg gacctgctgg ccagccacag      180

cgcggaggac gaggccgagg acagtgccat gtcgcccatc cccgtggggc caccgtcccc      240

cttccccacc agcgaggact tcacccccaa ggagggctcg ccgtacgagg cccctgtcta      300

cattcctgaa gacattccga tcccagcaga cttcgagctc cgagagtcct ccatcccagg      360

ggctggcctg ggggtctggg ccaagaggaa gatggaagcc ggggagaggc tgggcccctg      420

cgtggtggtg ccccgggcgg cggcaaagga gacagacttc ggatgggagc aaatactgac      480

ggacgtggaa gtgtcgcccc aggaaggctg catcacaaag atctccgaag acctgggcag      540

tgagaagttc tgcgtggatg caaatcaggc gggggctggc agctggctca agtacatccg      600

tgtggcgtgc tcctgcgatg accagaacct caccatgtgt cagatcagtg agcagattta      660

ctataaagtc attaaggaca ttgagccagg tgaggagctg ctggtgcacg tgaaggaagg      720

cgtctacccc ctgggcacag tgccgcccgg cctggacgag gagcccacgt tccgctgtga      780

cgagtgtgac gaactcttcc agtccaagct ggacctgcgg cgccataaga agtacacgtg      840

tggctcagtg ggggctgcgc tctacgaggg cctggctgag gagctcaagc ccgagggcct      900

tggcggtggc agcggccaag cccacgagtg caaggactgc gagcggatgt tccccaacaa      960

gtacagcctg gagcagcaca tggtcatcca cacggaggag cgcgagtaca aatgcgacca     1020

gtgtcccaag gccttcaact ggaagtccaa cctcatccgc caccagatgt cccacgacag     1080

cggcaaacgc ttcgaatgtg aaaactgcgt gaaggtgttc acggacccca gcaaccttca     1140

gcggcacatc cgctcgcagc acgtgggcgc tcgggcccac gcctgccccg actgcgggaa     1200

gaccttcgcc acgtcctccg gcctcaagca gcacaagcat atccacagca cggtgaagcc     1260

tttcatatgt gaggtctgcc acaagtccta cacgcagttc tccaacctgt gccggcacaa     1320

gcggatgcac gccgactgcc gcacgcagat caagtgcaag gactgtggcc agatgttcag     1380

cactacctcc tccctcaaca agcaccggcg cttctgcgag ggcaagaacc attacacgcc     1440

gggcggcatc tttgccccgg gcctgccctt gacccccagc cccatgatgg acaaggcaaa     1500

accctccccc agcctcaatc acgccagcct gggcttcaac gagtactttc cctccaggcc     1560

gcacccgggg agcctgccct tctccacggc gcctcccacg ttccccgcac tcacccccgg     1620

cttcccgggc atcttccctc catccttgta cccccggccg cctctgctac ctcccacatc     1680

gctgctcaag agccccctga accacaccca ggacgccaag ctccccagtc ccctggggaa     1740

cccagccctg cccctggtct ccgccgtcag caacagcagc cagggcacga cggcagctgc     1800

ggggcccgag gagaagttcg agagccgcct ggaggactcc tgtgtggaga agctgaagac     1860

caggagcagc gacatgtcgg acggcagtga ctttgaggac gtcaacacca ccacggggac     1920

cgacctggac acgaccacgg ggacgggctc ggacctggac agcgacgtgg acagcgaccc     1980

tgacaaggac aagggcaagg gcaagtccgc cgagggccag cccaagtttg ggggcggctt     2040

ggcgcccccg ggggccccga acagcgtggc cgaggtgcct gtcttctatt cccagcactc     2100

attcttcccg ccacccgacg agcagctgct gactgcaacg ggcgccgccg gggactccat     2160

caaggccatc gcatccattg ccgagaagta ctttggcccc ggcttcatgg ggatgcagga     2220

gaagaagctg ggctcgctcc cctaccactc ggcgttcccc ttccagttcc tgcccaactt     2280

cccccactcc ctttacccct tcacggaccg agccctcgcc cacaacttgc tggtcaaggc     2340

cgagccaaag tcaccccggg acgccctcaa ggtgggcggc cccagtgccg agtgcccctt     2400

tgatctcacc accaagccca aagacgtgaa gcccatcctg cccatgccca agggcccctc     2460

ggcccccgca tccggcgagg agcagccgct ggacctgagc atcggcagcc gggcccgtgc     2520

cagccaaaac ggcggcgggc gggagccccg caagaaccac gtctatgggg aacgcaagct     2580

gggcgccggc gaggggctgc cccaggtgtg cccggcgcgg atgccccagc agcccccgct     2640

ccactacgcc aagccctcgc ccttcttcat ggaccccatc tacagcaggg tagaaaagcg     2700

gaaggtcaca gaccccgtgg gagccctgaa ggagaagtac ctgcggccgt ccccgctgct     2760

cttccacccc cagatgtcag ccatagagac catgacagag aagctggaga gctttgcagc     2820

catgaaggcg gactcgggca gctccctgca gcccctcccc caccacccct tcaacttccg     2880

gtccccaccc ccaacgctct ccgaccccat cctcaggaag ggcaaggagc gatacacgtg     2940

caggtactgt gggaagatct tccccagatc agccaatctc accagacacc tgaggacgca     3000

cactggggag cagccgtaca ggtgtaagta ctgcgaccgc tccttcagca tctcttcgaa     3060

cctccagcgg cacgtccgga acatccacaa caaggagaag cctttcaagt gccacctgtg     3120

caaccgctgc ttcgggcagc agaccaacct ggaccggcac ctcaagaagc acgagcacga     3180

gaacgcacca gtgagccagc accccggggt cctcacgaac cacctgggga ccagcgcgtc     3240

ctctcccacc tcagagtcgg acaaccacgc acttttagac gagaaagaag actcttattt     3300

ctcggaaatc agaaacttta ttgccaatag tgagatgaac caagcatcaa cgcgaacaga     3360

gaaacgggcg gacatgcaga tcgtggacgg cagtgcccag tgtccaggcc tagccagtga     3420

gaagcaggag gacgtggagg aggaggacga cgatgacctg gaggaggacg atgaggacag     3480

cctggccggg aagtcgcagg atgacaccgt gtcccccgca cccgagcccc aggccgccta     3540

cgaggatgag gaggatgagg agccagccgc ctccctggcc gtgggctttg accacacccg     3600

aaggtgtgct gaggaccacg aaggcggtct gttagctttg gagccgatgc cgacttttgg     3660

gaaggggctg gacctccgca gagcagctga ggaagcattt gaagttaaag atgtgcttaa     3720

ttccacctta gattctgagg ctttaaaaca tacactgtgc aggcaggcta agaaccaggg     3780

ttctctggac gcttggttga aggtcactgg agccacgtcg gagtctggag catttcaccc     3840

catcaaccac ctctgacggg ctgggcagcc gggggccggt ggccagagcg agggcaccag     3900

ccacgaagga cggaggcggg cggggccccg gagaaccctg tccctgcgtg tggccactcc     3960

tcagcatcct ccccacccac catggttcat tccgactttt ccaatggaaa ctcagatccc     4020

aaaagtccct aaagcagtcg tagagtctca ccatctccaa ggattggtct tgagaacact     4080

gttcagtgac ggccatgcag gtggccgtcc aaagacagcc aacggagctg cctcgcagaa     4140

tcagccagtg ggcaggtgga cgctctgctg agacagaagc tggtggccac tgccgggtgc     4200

ccgcgtgggg tcgcggaagg gaatggatag actggtgtgc tcaaaagaga gagatcactc     4260

aaatgatttt tataatgaaa tgacaagaat aacccttttg gtaaccgtat tgactgcaga     4320

gtctatttaa gcatgtggtt ttaaaaatag acagtatttt ttaaaaatca aaaaatgact     4380

tgcaaattgt tttttaaaag taattttgca ttgctttgaa atttgagctc atttgcaaac     4440

ccgagtctgc ctgggaaccc gcactgtgcc tgggtgtatt ctttatactg tagataatgg     4500

agaaattttc tatctctgtc cctatttgta taagccaagg tgatgctggg tgccccgagg     4560

cagaacaaga ggcgcggggc cacacccgtg aaccatgcag acggccgaag aagtcttagg     4620

cagggcgccc tgggctgcag gcctgcccga ggctgggatg ggaagtgtgc ctgccctcgt     4680

gtgacatgga attggtgtca ggaccgccac gtggccttca gaggaatcca caggtcccca     4740

cccaagatcc ctcaattata tggggaagtc gagggcctgt ggcttggatc cgccatgcag     4800

agatgtggcc gggcacccat cttccttccc tcctctgtcc ctgcctcggc caccccacgc     4860

gggaacccag cgccgtcctc tgaaggcagg gccttggcca cgtcctgggt ctcccacctc     4920

ccacctgacc ccagcggctc cggtgtcctc cacgtggctg ccctggggag caatcccagc     4980

ggatcgctcc gggccaccaa gccgcacctg tgcctgagac tccggatgga cgacacagtc     5040

gtcacgtcgc tcttcctgcg ggttcttggc gagacacagc ttgagaacag aagggcgtcg     5100

ggggaacctg ccgcaaggag cagagacagc acagcccccc gggcccagcc gcctccctct     5160

cttgggacgc aacttcttcc ccactcggat gggctttaaa ttattcccat aggggccaat     5220

ttcaaataat aatttttttc cctgatggaa tttaccttaa tctgtatata acttgtaatt     5280

ttttctaatt catttctttt cttattttat ttcctcctta acagtatttt tggcattaga     5340

cattcttatt gtgaagaaat aatgttaata taagtatctg gtgaaggacc aaaaccgtgt     5400

gataaggttg tgtgtcgtgt gggagtgggg cgatttttta tgtgccaaat acccccgtcc     5460

cccccatgaa tcctgctgtc cctgctgccg tttaccagac aatcatatgt ttttgttaaa     5520

tttgcgtttc agttacattt gcatttaaga caagtgttct atttatttct tgtattgttt     5580

ggaagaaaaa atgatgatag agtcccaaaa agaagagaaa aaaaatgccc aagttgccct     5640

ttaaaaaaaa agagcgtaaa tacaaacagg agtggtgcaa gccgccttgg tgtgggtttg     5700

tgtcacgtgt ggacatctcc tcaggctttg tgtcacgcgt ggacatctcc tcaggctgtc     5760

cccagcggtg acgggaggtg tcctggctgc tccaggacaa aagacaatcg tctctgtggg     5820

tgccgggtgg tccaggcttg cactgaagac gtgccacggg gaggctcctg caggaggctc     5880

aacccgacgg atcacagtga aagggattcc tcccacgcca gatctgcaca acgaggcaag     5940

acaggaccca cctgtgcgtg cgctggggcc atggggtggc cccgccgggg cagcggggga     6000

gctgcctgca gaagagccag ctggcgtgtc gggaaggatc caggatctgc aaacacaact     6060

gctcaggcct tctcacgcgt ttccacaaca tcccctgggt cagacccacc aggtaccccg     6120

taggaatttc cagtttccct tgatctagat gggattctta taaaaattca acctcagaca     6180

taaacacccc atttctgtaa acccaaatta tatggtttct tctgcgaaag agtaaggtgt     6240

gtgctttttt ttttttgcaa tatgaccccg tctctctgaa gtgggacatt cggacggatg     6300

gagccctcag cgtgtctttt cagcaggagc agaaccgatg agagccgccc ttaccgttgg     6360

tctccggatc ccccagtccc atcccgccgt tttcggctgt cttcctaacc gtcctgtctt     6420

ctcttggcgc tctttccttc cacctttccc aagagtcctg gttgcacgtt ttaagtcata     6480

tattttcgtc cccctgaaaa tgatggcaag cccagtttct cctgagcatt cagaccccca     6540

ggccccagca cttggcgttt tcaggaggcc ctgttcttag agcccctgac aaaggcagca     6600

cttatttcct gggctggtgc gccccaaaac acggccccga cacttagtgt ggccccaggc     6660

cccagcgagc ctcgccctcc cagttttgct ctgcccagca gtgttggtgc ccagagatga     6720

caagggccag ggagcctggc ccgggtgtga gaattcagag attctggcct ccagctgtca     6780

ccacaccgta acggggccat gtaactgtgc agcatggaca gggatgcgac ggggcagctg     6840

gctgtgtcca tggccaggtg gccagggtca gggctgcaag ccaggggtcc agggcccttc     6900

cgttcagccc aaatgctgcc ccaatgctaa ctccttggat tgtcaacccc catcccccaa     6960

atggaaattc cgaaggaggc ctcctcgcac ctgccctccg ctgctcctca gaccccagcc     7020

cccagcgagc cgacgtcccc acccgttcct gctctcatcc ccaggttggg cacgtggggt     7080

tcctcctctg tgggcctggc agacccttca tgagtgggac ccaagatatc actgacttca     7140

acccagagga tcgagcccct gcaccctgcc tggggccctg gggtgtggag cagtggctgg     7200

ggtgggcgtg gtgtggcctg agagactgcc cagctggaga ggccttcctt tacaaggcca     7260

cgcgtgcagc tgtcccatcc agaccccgac tggccaagac ctccacgtcc ccagagtcca     7320

gccctggaaa ttccaagggc cctggcgtcc tctgccttcc ccgcttcccc atgagcgtct     7380

gcaaaacact tgcctgaata catatcacgt attttagact cgaagcctca aagcactgga     7440

ttgtggtccc ctgccccctc tgtcccgtcc ccctgcccaa gtgactgaaa cctactgagc     7500

tatattcact gtgctgtcct agggggaggg agagcagagc tcgcccctgc actgcagcct     7560

tgtgggggag ggcaaggctc tcctcccagc cagggacgcc aggacatagc tgctcctggt     7620

cagtggaggt cagccgggta tcaaaagcca tgaaactgtg tctctgtagc aatgagtgat     7680

actgtgacaa aaccatcctt gcattcttcc tagaagagtt cctctgctcc ttccattcca     7740

tttttgtgtt tgttttgttc ttttctgtca ctgatccgta ttaccacttt tggaaaaaaa     7800

taaataaata aataaataaa aggcagcttg agtttccaaa cgtgtgattc acttgtgaac     7860

aaaagtcatt ctaacaattg ccttcagcgt cacgtgcatt gccactgcgc tttcggcacg     7920

agggatgctg agccctggtg tcagagtcgt aatttaaagc gtgtgtgtat atggactttg     7980

tcccttaagg tcgatataaa gaatcctcgc agaatcacag acctgtgccg cccgccacct     8040

tctgccattg ttacattaca gatttggttt agttttgttt tgttttgttt tttcttttag     8100

aactgtatag tattgaaaaa gaaatcaaat gtaaatgtct ggttttcata taatgtttaa     8160

aaagaccatt gagaaggagg ctggcgctcg ccccatgtcc cccttgattg taaattgctt     8220

ctgttctgtt tataagtaaa ctgtgcatga ctcctgctta gcggtcatta tcgtgtctgt     8280

tggtgaaatt tttattaaaa ggaaaattct gtagatgcac ttattgaata tgtgattagg     8340

atctacgtct gagactagga gtcctgaact gctgacgcga aagaggcgca gttcccaatt     8400

aatacggaaa tcgctgtggg agaagaatga aataagacgt gaagtgtagg aaatcatgaa     8460

aagaacaatt ttgcaaattg cattctgatg cttgtgatga acacaaatgt acttgtgtag     8520

agacatttcc ttaagagaaa gcctaggaga agccgatttg gaggttaatg ctgtagaata     8580

ggactgtata ccaaatgtaa tctttccaat gctccaatga atttatacat gagattgata     8640

tgcaataaat ctgtgtgctt ttctaaaaaa aaaa                                 8674


<210> 7
<211> 1276
<212> PRT
<213> Homo sapiens

<400> 7
Met Arg Ser Lys Ala Arg Ala Arg Lys Leu Ala Lys Ser Asp Gly Asp 
1               5                   10                  15      


Val Val Asn Asn Met Tyr Glu Pro Asn Arg Asp Leu Leu Ala Ser His 
            20                  25                  30          


Ser Ala Glu Asp Glu Ala Glu Asp Ser Ala Met Ser Pro Ile Pro Val 
        35                  40                  45              


Gly Pro Pro Ser Pro Phe Pro Thr Ser Glu Asp Phe Thr Pro Lys Glu 
    50                  55                  60                  


Gly Ser Pro Tyr Glu Ala Pro Val Tyr Ile Pro Glu Asp Ile Pro Ile 
65                  70                  75                  80  


Pro Ala Asp Phe Glu Leu Arg Glu Ser Ser Ile Pro Gly Ala Gly Leu 
                85                  90                  95      


Gly Val Trp Ala Lys Arg Lys Met Glu Ala Gly Glu Arg Leu Gly Pro 
            100                 105                 110         


Cys Val Val Val Pro Arg Ala Ala Ala Lys Glu Thr Asp Phe Gly Trp 
        115                 120                 125             


Glu Gln Ile Leu Thr Asp Val Glu Val Ser Pro Gln Glu Gly Cys Ile 
    130                 135                 140                 


Thr Lys Ile Ser Glu Asp Leu Gly Ser Glu Lys Phe Cys Val Asp Ala 
145                 150                 155                 160 


Asn Gln Ala Gly Ala Gly Ser Trp Leu Lys Tyr Ile Arg Val Ala Cys 
                165                 170                 175     


Ser Cys Asp Asp Gln Asn Leu Thr Met Cys Gln Ile Ser Glu Gln Ile 
            180                 185                 190         


Tyr Tyr Lys Val Ile Lys Asp Ile Glu Pro Gly Glu Glu Leu Leu Val 
        195                 200                 205             


His Val Lys Glu Gly Val Tyr Pro Leu Gly Thr Val Pro Pro Gly Leu 
    210                 215                 220                 


Asp Glu Glu Pro Thr Phe Arg Cys Asp Glu Cys Asp Glu Leu Phe Gln 
225                 230                 235                 240 


Ser Lys Leu Asp Leu Arg Arg His Lys Lys Tyr Thr Cys Gly Ser Val 
                245                 250                 255     


Gly Ala Ala Leu Tyr Glu Gly Leu Ala Glu Glu Leu Lys Pro Glu Gly 
            260                 265                 270         


Leu Gly Gly Gly Ser Gly Gln Ala His Glu Cys Lys Asp Cys Glu Arg 
        275                 280                 285             


Met Phe Pro Asn Lys Tyr Ser Leu Glu Gln His Met Val Ile His Thr 
    290                 295                 300                 


Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe Asn Trp 
305                 310                 315                 320 


Lys Ser Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly Lys Arg 
                325                 330                 335     


Phe Glu Cys Glu Asn Cys Val Lys Val Phe Thr Asp Pro Ser Asn Leu 
            340                 345                 350         


Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala His Ala Cys 
        355                 360                 365             


Pro Asp Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys Gln His 
    370                 375                 380                 


Lys His Ile His Ser Thr Val Lys Pro Phe Ile Cys Glu Val Cys His 
385                 390                 395                 400 


Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg Met His 
                405                 410                 415     


Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln Met Phe 
            420                 425                 430         


Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu Gly Lys 
        435                 440                 445             


Asn His Tyr Thr Pro Gly Gly Ile Phe Ala Pro Gly Leu Pro Leu Thr 
    450                 455                 460                 


Pro Ser Pro Met Met Asp Lys Ala Lys Pro Ser Pro Ser Leu Asn His 
465                 470                 475                 480 


Ala Ser Leu Gly Phe Asn Glu Tyr Phe Pro Ser Arg Pro His Pro Gly 
                485                 490                 495     


Ser Leu Pro Phe Ser Thr Ala Pro Pro Thr Phe Pro Ala Leu Thr Pro 
            500                 505                 510         


Gly Phe Pro Gly Ile Phe Pro Pro Ser Leu Tyr Pro Arg Pro Pro Leu 
        515                 520                 525             


Leu Pro Pro Thr Ser Leu Leu Lys Ser Pro Leu Asn His Thr Gln Asp 
    530                 535                 540                 


Ala Lys Leu Pro Ser Pro Leu Gly Asn Pro Ala Leu Pro Leu Val Ser 
545                 550                 555                 560 


Ala Val Ser Asn Ser Ser Gln Gly Thr Thr Ala Ala Ala Gly Pro Glu 
                565                 570                 575     


Glu Lys Phe Glu Ser Arg Leu Glu Asp Ser Cys Val Glu Lys Leu Lys 
            580                 585                 590         


Thr Arg Ser Ser Asp Met Ser Asp Gly Ser Asp Phe Glu Asp Val Asn 
        595                 600                 605             


Thr Thr Thr Gly Thr Asp Leu Asp Thr Thr Thr Gly Thr Gly Ser Asp 
    610                 615                 620                 


Leu Asp Ser Asp Val Asp Ser Asp Pro Asp Lys Asp Lys Gly Lys Gly 
625                 630                 635                 640 


Lys Ser Ala Glu Gly Gln Pro Lys Phe Gly Gly Gly Leu Ala Pro Pro 
                645                 650                 655     


Gly Ala Pro Asn Ser Val Ala Glu Val Pro Val Phe Tyr Ser Gln His 
            660                 665                 670         


Ser Phe Phe Pro Pro Pro Asp Glu Gln Leu Leu Thr Ala Thr Gly Ala 
        675                 680                 685             


Ala Gly Asp Ser Ile Lys Ala Ile Ala Ser Ile Ala Glu Lys Tyr Phe 
    690                 695                 700                 


Gly Pro Gly Phe Met Gly Met Gln Glu Lys Lys Leu Gly Ser Leu Pro 
705                 710                 715                 720 


Tyr His Ser Ala Phe Pro Phe Gln Phe Leu Pro Asn Phe Pro His Ser 
                725                 730                 735     


Leu Tyr Pro Phe Thr Asp Arg Ala Leu Ala His Asn Leu Leu Val Lys 
            740                 745                 750         


Ala Glu Pro Lys Ser Pro Arg Asp Ala Leu Lys Val Gly Gly Pro Ser 
        755                 760                 765             


Ala Glu Cys Pro Phe Asp Leu Thr Thr Lys Pro Lys Asp Val Lys Pro 
    770                 775                 780                 


Ile Leu Pro Met Pro Lys Gly Pro Ser Ala Pro Ala Ser Gly Glu Glu 
785                 790                 795                 800 


Gln Pro Leu Asp Leu Ser Ile Gly Ser Arg Ala Arg Ala Ser Gln Asn 
                805                 810                 815     


Gly Gly Gly Arg Glu Pro Arg Lys Asn His Val Tyr Gly Glu Arg Lys 
            820                 825                 830         


Leu Gly Ala Gly Glu Gly Leu Pro Gln Val Cys Pro Ala Arg Met Pro 
        835                 840                 845             


Gln Gln Pro Pro Leu His Tyr Ala Lys Pro Ser Pro Phe Phe Met Asp 
    850                 855                 860                 


Pro Ile Tyr Ser Arg Val Glu Lys Arg Lys Val Thr Asp Pro Val Gly 
865                 870                 875                 880 


Ala Leu Lys Glu Lys Tyr Leu Arg Pro Ser Pro Leu Leu Phe His Pro 
                885                 890                 895     


Gln Met Ser Ala Ile Glu Thr Met Thr Glu Lys Leu Glu Ser Phe Ala 
            900                 905                 910         


Ala Met Lys Ala Asp Ser Gly Ser Ser Leu Gln Pro Leu Pro His His 
        915                 920                 925             


Pro Phe Asn Phe Arg Ser Pro Pro Pro Thr Leu Ser Asp Pro Ile Leu 
    930                 935                 940                 


Arg Lys Gly Lys Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe 
945                 950                 955                 960 


Pro Arg Ser Ala Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu 
                965                 970                 975     


Gln Pro Tyr Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser 
            980                 985                 990         


Asn Leu Gln Arg His Val Arg Asn  Ile His Asn Lys Glu  Lys Pro Phe 
        995                 1000                 1005             


Lys Cys  His Leu Cys Asn Arg  Cys Phe Gly Gln Gln  Thr Asn Leu 
    1010                 1015                 1020             


Asp Arg  His Leu Lys Lys His  Glu His Glu Asn Ala  Pro Val Ser 
    1025                 1030                 1035             


Gln His  Pro Gly Val Leu Thr  Asn His Leu Gly Thr  Ser Ala Ser 
    1040                 1045                 1050             


Ser Pro  Thr Ser Glu Ser Asp  Asn His Ala Leu Leu  Asp Glu Lys 
    1055                 1060                 1065             


Glu Asp  Ser Tyr Phe Ser Glu  Ile Arg Asn Phe Ile  Ala Asn Ser 
    1070                 1075                 1080             


Glu Met  Asn Gln Ala Ser Thr  Arg Thr Glu Lys Arg  Ala Asp Met 
    1085                 1090                 1095             


Gln Ile  Val Asp Gly Ser Ala  Gln Cys Pro Gly Leu  Ala Ser Glu 
    1100                 1105                 1110             


Lys Gln  Glu Asp Val Glu Glu  Glu Asp Asp Asp Asp  Leu Glu Glu 
    1115                 1120                 1125             


Asp Asp  Glu Asp Ser Leu Ala  Gly Lys Ser Gln Asp  Asp Thr Val 
    1130                 1135                 1140             


Ser Pro  Ala Pro Glu Pro Gln  Ala Ala Tyr Glu Asp  Glu Glu Asp 
    1145                 1150                 1155             


Glu Glu  Pro Ala Ala Ser Leu  Ala Val Gly Phe Asp  His Thr Arg 
    1160                 1165                 1170             


Arg Cys  Ala Glu Asp His Glu  Gly Gly Leu Leu Ala  Leu Glu Pro 
    1175                 1180                 1185             


Met Pro  Thr Phe Gly Lys Gly  Leu Asp Leu Arg Arg  Ala Ala Glu 
    1190                 1195                 1200             


Glu Ala  Phe Glu Val Lys Asp  Val Leu Asn Ser Thr  Leu Asp Ser 
    1205                 1210                 1215             


Glu Ala  Leu Lys His Thr Leu  Cys Arg Gln Ala Lys  Asn Gln Ala 
    1220                 1225                 1230             


Tyr Ala  Met Met Leu Ser Leu  Ser Glu Asp Thr Pro  Leu His Thr 
    1235                 1240                 1245             


Pro Ser  Gln Gly Ser Leu Asp  Ala Trp Leu Lys Val  Thr Gly Ala 
    1250                 1255                 1260             


Thr Ser  Glu Ser Gly Ala Phe  His Pro Ile Asn His  Leu 
    1265                 1270                 1275     


<210> 8
<211> 1257
<212> PRT
<213> Homo sapiens

<400> 8
Met Arg Ser Lys Ala Arg Ala Arg Lys Leu Ala Lys Ser Asp Gly Asp 
1               5                   10                  15      


Val Val Asn Asn Met Tyr Glu Pro Asn Arg Asp Leu Leu Ala Ser His 
            20                  25                  30          


Ser Ala Glu Asp Glu Ala Glu Asp Ser Ala Met Ser Pro Ile Pro Val 
        35                  40                  45              


Gly Pro Pro Ser Pro Phe Pro Thr Ser Glu Asp Phe Thr Pro Lys Glu 
    50                  55                  60                  


Gly Ser Pro Tyr Glu Ala Pro Val Tyr Ile Pro Glu Asp Ile Pro Ile 
65                  70                  75                  80  


Pro Ala Asp Phe Glu Leu Arg Glu Ser Ser Ile Pro Gly Ala Gly Leu 
                85                  90                  95      


Gly Val Trp Ala Lys Arg Lys Met Glu Ala Gly Glu Arg Leu Gly Pro 
            100                 105                 110         


Cys Val Val Val Pro Arg Ala Ala Ala Lys Glu Thr Asp Phe Gly Trp 
        115                 120                 125             


Glu Gln Ile Leu Thr Asp Val Glu Val Ser Pro Gln Glu Gly Cys Ile 
    130                 135                 140                 


Thr Lys Ile Ser Glu Asp Leu Gly Ser Glu Lys Phe Cys Val Asp Ala 
145                 150                 155                 160 


Asn Gln Ala Gly Ala Gly Ser Trp Leu Lys Tyr Ile Arg Val Ala Cys 
                165                 170                 175     


Ser Cys Asp Asp Gln Asn Leu Thr Met Cys Gln Ile Ser Glu Gln Ile 
            180                 185                 190         


Tyr Tyr Lys Val Ile Lys Asp Ile Glu Pro Gly Glu Glu Leu Leu Val 
        195                 200                 205             


His Val Lys Glu Gly Val Tyr Pro Leu Gly Thr Val Pro Pro Gly Leu 
    210                 215                 220                 


Asp Glu Glu Pro Thr Phe Arg Cys Asp Glu Cys Asp Glu Leu Phe Gln 
225                 230                 235                 240 


Ser Lys Leu Asp Leu Arg Arg His Lys Lys Tyr Thr Cys Gly Ser Val 
                245                 250                 255     


Gly Ala Ala Leu Tyr Glu Gly Leu Ala Glu Glu Leu Lys Pro Glu Gly 
            260                 265                 270         


Leu Gly Gly Gly Ser Gly Gln Ala His Glu Cys Lys Asp Cys Glu Arg 
        275                 280                 285             


Met Phe Pro Asn Lys Tyr Ser Leu Glu Gln His Met Val Ile His Thr 
    290                 295                 300                 


Glu Glu Arg Glu Tyr Lys Cys Asp Gln Cys Pro Lys Ala Phe Asn Trp 
305                 310                 315                 320 


Lys Ser Asn Leu Ile Arg His Gln Met Ser His Asp Ser Gly Lys Arg 
                325                 330                 335     


Phe Glu Cys Glu Asn Cys Val Lys Val Phe Thr Asp Pro Ser Asn Leu 
            340                 345                 350         


Gln Arg His Ile Arg Ser Gln His Val Gly Ala Arg Ala His Ala Cys 
        355                 360                 365             


Pro Asp Cys Gly Lys Thr Phe Ala Thr Ser Ser Gly Leu Lys Gln His 
    370                 375                 380                 


Lys His Ile His Ser Thr Val Lys Pro Phe Ile Cys Glu Val Cys His 
385                 390                 395                 400 


Lys Ser Tyr Thr Gln Phe Ser Asn Leu Cys Arg His Lys Arg Met His 
                405                 410                 415     


Ala Asp Cys Arg Thr Gln Ile Lys Cys Lys Asp Cys Gly Gln Met Phe 
            420                 425                 430         


Ser Thr Thr Ser Ser Leu Asn Lys His Arg Arg Phe Cys Glu Gly Lys 
        435                 440                 445             


Asn His Tyr Thr Pro Gly Gly Ile Phe Ala Pro Gly Leu Pro Leu Thr 
    450                 455                 460                 


Pro Ser Pro Met Met Asp Lys Ala Lys Pro Ser Pro Ser Leu Asn His 
465                 470                 475                 480 


Ala Ser Leu Gly Phe Asn Glu Tyr Phe Pro Ser Arg Pro His Pro Gly 
                485                 490                 495     


Ser Leu Pro Phe Ser Thr Ala Pro Pro Thr Phe Pro Ala Leu Thr Pro 
            500                 505                 510         


Gly Phe Pro Gly Ile Phe Pro Pro Ser Leu Tyr Pro Arg Pro Pro Leu 
        515                 520                 525             


Leu Pro Pro Thr Ser Leu Leu Lys Ser Pro Leu Asn His Thr Gln Asp 
    530                 535                 540                 


Ala Lys Leu Pro Ser Pro Leu Gly Asn Pro Ala Leu Pro Leu Val Ser 
545                 550                 555                 560 


Ala Val Ser Asn Ser Ser Gln Gly Thr Thr Ala Ala Ala Gly Pro Glu 
                565                 570                 575     


Glu Lys Phe Glu Ser Arg Leu Glu Asp Ser Cys Val Glu Lys Leu Lys 
            580                 585                 590         


Thr Arg Ser Ser Asp Met Ser Asp Gly Ser Asp Phe Glu Asp Val Asn 
        595                 600                 605             


Thr Thr Thr Gly Thr Asp Leu Asp Thr Thr Thr Gly Thr Gly Ser Asp 
    610                 615                 620                 


Leu Asp Ser Asp Val Asp Ser Asp Pro Asp Lys Asp Lys Gly Lys Gly 
625                 630                 635                 640 


Lys Ser Ala Glu Gly Gln Pro Lys Phe Gly Gly Gly Leu Ala Pro Pro 
                645                 650                 655     


Gly Ala Pro Asn Ser Val Ala Glu Val Pro Val Phe Tyr Ser Gln His 
            660                 665                 670         


Ser Phe Phe Pro Pro Pro Asp Glu Gln Leu Leu Thr Ala Thr Gly Ala 
        675                 680                 685             


Ala Gly Asp Ser Ile Lys Ala Ile Ala Ser Ile Ala Glu Lys Tyr Phe 
    690                 695                 700                 


Gly Pro Gly Phe Met Gly Met Gln Glu Lys Lys Leu Gly Ser Leu Pro 
705                 710                 715                 720 


Tyr His Ser Ala Phe Pro Phe Gln Phe Leu Pro Asn Phe Pro His Ser 
                725                 730                 735     


Leu Tyr Pro Phe Thr Asp Arg Ala Leu Ala His Asn Leu Leu Val Lys 
            740                 745                 750         


Ala Glu Pro Lys Ser Pro Arg Asp Ala Leu Lys Val Gly Gly Pro Ser 
        755                 760                 765             


Ala Glu Cys Pro Phe Asp Leu Thr Thr Lys Pro Lys Asp Val Lys Pro 
    770                 775                 780                 


Ile Leu Pro Met Pro Lys Gly Pro Ser Ala Pro Ala Ser Gly Glu Glu 
785                 790                 795                 800 


Gln Pro Leu Asp Leu Ser Ile Gly Ser Arg Ala Arg Ala Ser Gln Asn 
                805                 810                 815     


Gly Gly Gly Arg Glu Pro Arg Lys Asn His Val Tyr Gly Glu Arg Lys 
            820                 825                 830         


Leu Gly Ala Gly Glu Gly Leu Pro Gln Val Cys Pro Ala Arg Met Pro 
        835                 840                 845             


Gln Gln Pro Pro Leu His Tyr Ala Lys Pro Ser Pro Phe Phe Met Asp 
    850                 855                 860                 


Pro Ile Tyr Ser Arg Val Glu Lys Arg Lys Val Thr Asp Pro Val Gly 
865                 870                 875                 880 


Ala Leu Lys Glu Lys Tyr Leu Arg Pro Ser Pro Leu Leu Phe His Pro 
                885                 890                 895     


Gln Met Ser Ala Ile Glu Thr Met Thr Glu Lys Leu Glu Ser Phe Ala 
            900                 905                 910         


Ala Met Lys Ala Asp Ser Gly Ser Ser Leu Gln Pro Leu Pro His His 
        915                 920                 925             


Pro Phe Asn Phe Arg Ser Pro Pro Pro Thr Leu Ser Asp Pro Ile Leu 
    930                 935                 940                 


Arg Lys Gly Lys Glu Arg Tyr Thr Cys Arg Tyr Cys Gly Lys Ile Phe 
945                 950                 955                 960 


Pro Arg Ser Ala Asn Leu Thr Arg His Leu Arg Thr His Thr Gly Glu 
                965                 970                 975     


Gln Pro Tyr Arg Cys Lys Tyr Cys Asp Arg Ser Phe Ser Ile Ser Ser 
            980                 985                 990         


Asn Leu Gln Arg His Val Arg Asn  Ile His Asn Lys Glu  Lys Pro Phe 
        995                 1000                 1005             


Lys Cys  His Leu Cys Asn Arg  Cys Phe Gly Gln Gln  Thr Asn Leu 
    1010                 1015                 1020             


Asp Arg  His Leu Lys Lys His  Glu His Glu Asn Ala  Pro Val Ser 
    1025                 1030                 1035             


Gln His  Pro Gly Val Leu Thr  Asn His Leu Gly Thr  Ser Ala Ser 
    1040                 1045                 1050             


Ser Pro  Thr Ser Glu Ser Asp  Asn His Ala Leu Leu  Asp Glu Lys 
    1055                 1060                 1065             


Glu Asp  Ser Tyr Phe Ser Glu  Ile Arg Asn Phe Ile  Ala Asn Ser 
    1070                 1075                 1080             


Glu Met  Asn Gln Ala Ser Thr  Arg Thr Glu Lys Arg  Ala Asp Met 
    1085                 1090                 1095             


Gln Ile  Val Asp Gly Ser Ala  Gln Cys Pro Gly Leu  Ala Ser Glu 
    1100                 1105                 1110             


Lys Gln  Glu Asp Val Glu Glu  Glu Asp Asp Asp Asp  Leu Glu Glu 
    1115                 1120                 1125             


Asp Asp  Glu Asp Ser Leu Ala  Gly Lys Ser Gln Asp  Asp Thr Val 
    1130                 1135                 1140             


Ser Pro  Ala Pro Glu Pro Gln  Ala Ala Tyr Glu Asp  Glu Glu Asp 
    1145                 1150                 1155             


Glu Glu  Pro Ala Ala Ser Leu  Ala Val Gly Phe Asp  His Thr Arg 
    1160                 1165                 1170             


Arg Cys  Ala Glu Asp His Glu  Gly Gly Leu Leu Ala  Leu Glu Pro 
    1175                 1180                 1185             


Met Pro  Thr Phe Gly Lys Gly  Leu Asp Leu Arg Arg  Ala Ala Glu 
    1190                 1195                 1200             


Glu Ala  Phe Glu Val Lys Asp  Val Leu Asn Ser Thr  Leu Asp Ser 
    1205                 1210                 1215             


Glu Ala  Leu Lys His Thr Leu  Cys Arg Gln Ala Lys  Asn Gln Gly 
    1220                 1225                 1230             


Ser Leu  Asp Ala Trp Leu Lys  Val Thr Gly Ala Thr  Ser Glu Ser 
    1235                 1240                 1245             


Gly Ala  Phe His Pro Ile Asn  His Leu 
    1250                 1255         


<210> 9
<211> 28
<212> PRT
<213> Homo sapiens

<400> 9
Met Gly Glu Thr Leu Gly Asp Ser Pro Ile Asp Pro Glu Ser Asp Ser 
1               5                   10                  15      


Phe Thr Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu 
            20                  25              


<210> 10
<211> 505
<212> PRT
<213> Mus musculus

<400> 10
Met Gly Glu Thr Leu Gly Asp Ser Pro Val Asp Pro Glu His Gly Ala 
1               5                   10                  15      


Phe Ala Asp Ala Leu Pro Met Ser Thr Ser Gln Glu Ile Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Ala Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Ala Asp Pro Met Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Arg Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Asn Ile Pro Gly Phe Ile Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Val Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu His Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210> 11
<211> 505
<212> PRT
<213> Rattus norvegicus

<400> 11
Met Gly Glu Thr Leu Gly Asp Pro Pro Val Asp Pro Glu His Gly Ala 
1               5                   10                  15      


Phe Ala Asp Ala Leu Pro Met Ser Thr Ser Gln Glu Ile Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Asp Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Ala Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Ala Asp Pro Met Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Arg Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Asn Ile Pro Gly Phe Ile Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Val Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu His Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210> 12
<211> 296
<212> PRT
<213> Mus musculus

<400> 12
Met His Arg Leu Leu Ala Trp Asp Ala Ala Cys Leu Pro Pro Pro Pro 
1               5                   10                  15      


Ala Ala Phe Arg Pro Met Glu Val Ala Asn Phe Tyr Tyr Glu Pro Asp 
            20                  25                  30          


Cys Leu Ala Tyr Gly Ala Lys Ala Ala Arg Ala Ala Pro Arg Ala Pro 
        35                  40                  45              


Ala Ala Glu Pro Ala Ile Gly Glu His Glu Arg Ala Ile Asp Phe Ser 
    50                  55                  60                  


Pro Tyr Leu Glu Pro Leu Ala Pro Ala Ala Asp Phe Ala Ala Pro Ala 
65                  70                  75                  80  


Pro Ala His His Asp Phe Leu Ser Asp Leu Phe Ala Asp Asp Tyr Gly 
                85                  90                  95      


Ala Lys Pro Ser Lys Lys Pro Ala Asp Tyr Gly Tyr Val Ser Leu Gly 
            100                 105                 110         


Arg Ala Gly Ala Lys Ala Ala Pro Pro Ala Cys Phe Pro Pro Pro Pro 
        115                 120                 125             


Pro Ala Ala Leu Lys Ala Glu Pro Gly Phe Glu Pro Ala Asp Cys Lys 
    130                 135                 140                 


Arg Ala Asp Asp Ala Pro Ala Met Ala Ala Gly Phe Pro Phe Ala Leu 
145                 150                 155                 160 


Arg Ala Tyr Leu Gly Tyr Gln Ala Thr Pro Ser Gly Ser Ser Gly Ser 
                165                 170                 175     


Leu Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro Ala 
            180                 185                 190         


Asp Ala Lys Ala Ala Pro Ala Ala Cys Phe Ala Gly Pro Pro Ala Ala 
        195                 200                 205             


Pro Ala Lys Ala Lys Ala Lys Lys Thr Val Asp Lys Leu Ser Asp Glu 
    210                 215                 220                 


Tyr Lys Met Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser Arg 
225                 230                 235                 240 


Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu Glu 
                245                 250                 255     


Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu Ser 
            260                 265                 270         


Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu Pro 
        275                 280                 285             


Leu Leu Ala Ser Ala Gly His Cys 
    290                 295     


<210> 13
<211> 297
<212> PRT
<213> Rattus norvegicus

<400> 13
Met His Arg Leu Leu Ala Trp Asp Ala Ala Cys Leu Pro Pro Pro Pro 
1               5                   10                  15      


Ala Ala Phe Arg Pro Met Glu Val Ala Asn Phe Tyr Tyr Glu Pro Asp 
            20                  25                  30          


Cys Leu Ala Tyr Gly Ala Lys Ala Ala Arg Ala Ala Pro Arg Ala Pro 
        35                  40                  45              


Ala Ala Glu Pro Ala Ile Gly Glu His Glu Arg Ala Ile Asp Phe Ser 
    50                  55                  60                  


Pro Tyr Leu Glu Pro Leu Ala Pro Ala Ala Ala Asp Phe Ala Ala Pro 
65                  70                  75                  80  


Ala Pro Ala His His Asp Phe Leu Ser Asp Leu Phe Ala Asp Asp Tyr 
                85                  90                  95      


Gly Ala Lys Pro Ser Lys Lys Pro Ser Asp Tyr Gly Tyr Val Ser Leu 
            100                 105                 110         


Gly Arg Ala Gly Ala Lys Ala Ala Pro Pro Ala Cys Phe Pro Pro Pro 
        115                 120                 125             


Pro Pro Ala Ala Leu Lys Ala Glu Pro Gly Phe Glu Pro Ala Asp Cys 
    130                 135                 140                 


Lys Arg Ala Asp Asp Ala Pro Ala Met Ala Ala Gly Phe Pro Phe Ala 
145                 150                 155                 160 


Leu Arg Ala Tyr Leu Gly Tyr Gln Ala Thr Pro Ser Gly Ser Ser Gly 
                165                 170                 175     


Ser Leu Ser Thr Ser Ser Ser Ser Ser Pro Pro Gly Thr Pro Ser Pro 
            180                 185                 190         


Ala Asp Ala Lys Ala Ala Pro Ala Ala Cys Phe Ala Gly Pro Pro Ala 
        195                 200                 205             


Ala Pro Ala Lys Ala Lys Ala Lys Lys Ala Val Asp Lys Leu Ser Asp 
    210                 215                 220                 


Glu Tyr Lys Met Arg Arg Glu Arg Asn Asn Ile Ala Val Arg Lys Ser 
225                 230                 235                 240 


Arg Asp Lys Ala Lys Met Arg Asn Leu Glu Thr Gln His Lys Val Leu 
                245                 250                 255     


Glu Leu Thr Ala Glu Asn Glu Arg Leu Gln Lys Lys Val Glu Gln Leu 
            260                 265                 270         


Ser Arg Glu Leu Ser Thr Leu Arg Asn Leu Phe Lys Gln Leu Pro Glu 
        275                 280                 285             


Pro Leu Leu Ala Ser Ala Gly His Cys 
    290                 295         


<210> 14
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 14
aggtcanagg tca                                                          13


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 15
caaaactagg tcaaaggtca                                                   20


<210> 16
<211> 13
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (4)..(4)
<223> a, c, t, g, unknown or other

<400> 16
aggncaaagg tca                                                          13


<210> 17
<211> 16
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (2)..(2)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (7)..(7)
<223> a, c, t, g, unknown or other

<400> 17
antgggncaa aggtca                                                       16


<210> 18
<211> 9
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"


<220>
<221> modified_base
<222> (3)..(4)
<223> a, c, t, g, unknown or other

<220>
<221> modified_base
<222> (6)..(6)
<223> a, c, t, g, unknown or other

<400> 18
tknngnaak                                                                9


<210> 19
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      oligonucleotide"

<400> 19
tcgcctagca tttcatcaca cgt                                               23


<210> 20
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 20
tgcaggtgat caagaagacg                                                   20


<210> 21
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 21
gcaggagatc tacaaggact tg                                                22


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 22
ccacgcctgt ccttagaaag                                                   20


<210> 23
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 23
gatgaagtcc tgtcttggaa gg                                                22


<210> 24
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 24
tcatgaaagg cgtcacttcc                                                   20


<210> 25
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 25
ctcagtgtgc tctccaagtg                                                   20


<210> 26
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 26
ctaagtaaaa gggtggagag gttc                                              24


<210> 27
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 27
tgacactggc aaaacaatgc a                                                 21


<210> 28
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 28
cttcgcgggg tagtgttgg                                                    19


<210> 29
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 29
atgtagttct gccccacagc                                                   20


<210> 30
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 30
tctacgacac ggtccagg                                                     18


<210> 31
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 31
gccaaaccaa caactttatc tcttc                                             25


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 32
cccggttcca cattgtaaga g                                                 21


<210> 33
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 33
aacgcggaga agtggaacaa g                                                 21


<210> 34
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 34
tttgtgggcc tgaagaaaac t                                                 21


<210> 35
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 35
gagcatttca ccccatcaac                                                   20


<210> 36
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 36
cacgcagaac ttctcactgc                                                   20


<210> 37
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 37
caaattttgt aatccagagg ttga                                              24


<210> 38
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 38
ccctcagaat agtgcaactg g                                                 21


<210> 39
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 39
ccctccacct tcatgtagaa c                                                 21


<210> 40
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 40
cagcacttag agatggagtt gg                                                22


<210> 41
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 41
gcttgctaaa tcagggaaaa ca                                                22


<210> 42
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 42
cacccaggcg gaagtctc                                                     18


<210> 43
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 43
ggtactccat ctggctcatt g                                                 21


<210> 44
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 44
ggtccttttc accagcaagc t                                                 21


<210> 45
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 45
ggccagactt cgacgacaa                                                    19


<210> 46
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 46
aaggacatga ggcccttttt                                                   20


<210> 47
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 47
gtctgacttt cacgacctct g                                                 21


<210> 48
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 48
cacacttaag gtgcgttcaa tagtc                                             25


<210> 49
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 49
gtatgcagtc acagcgatga at                                                22


<210> 50
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 50
ctgtccgagt ccaaatcgc                                                    19


<210> 51
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 51
agggctgtcc tgaataagca g                                                 21


<210> 52
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 52
ggagtctgga gcatttcacc                                                   20


<210> 53
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      primer"

<400> 53
atgggagcaa atactgacgg                                                   20


