                         SEQUENCE LISTING

<110>  Watson, David Edward
 
<120>  ANTI-GLUCAGON ANTIBODIES AND USES THEREOF

<130>  P18677

<160>  29    

<170>  PatentIn version 3.5

<210>  1
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Lys Ala Ser Glu Asn Ala Gly Thr Tyr Val Ala 
1               5                   10      


<210>  2
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Asn Gly Ser His Arg Tyr Asp 
1               5           


<210>  3
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Gly Gln Ser Tyr Ser Tyr Pro Trp Thr 
1               5                   


<210>  4
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gly Tyr Asn Phe Asn Asp Tyr Trp Leu Asn 
1               5                   10  


<210>  5
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Asn Ala Tyr Pro Gly Trp Gly Ile Ile Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Ser 
    


<210>  6
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Asp Tyr Asp Asn Ala Tyr 
1               5       


<210>  7
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Ala Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Gly Ser His Arg Tyr Asp Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys Arg 
            100                 105             


<210>  8
<211>  324
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8
aacattgtga tgacccagag cccgaaaagc atgagcatga gcgtgggcga acgtgtgacc       60

ctgacctgca aagcgagcga gaacgctggc acctatgttg cgtggtatca gcagaaaccg      120

gaacagtctc cgaaactgct gatctataat gggagccacc ggtatgacgg cgtgccggat      180

cgttttaccg gcagcggcag cgcgaccgat ttcaccctga ccattagcag cgtgcaggcg      240

gaagatctgg cggattatta ctgcggccag agctatagct atccgtggac ctttggcggt      300

gggaccaagc tggaaatgaa acgg                                             324


<210>  9
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gln Val Gln Leu Leu Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Asn Asp Tyr 
            20                  25                  30          


Trp Leu Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ala Tyr Pro Gly Trp Gly Ile Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Asn Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  10
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10
caggtgcagc tgctgcagcc gggtgccgaa ctggttaaac cgggtgccag cgtgaaactg       60

agctgcaaag cgagcggcta taacttcaac gactattggc ttaactgggt gaaacagcgt      120

ccgggccagg gcctggaatg gattggcaat gcctatccgg gctggggcat cattaactat      180

aacgaaaaat tcaaaagcaa agtgaccctg accgtggata ccagcagcag caccgtgtat      240

atgcagctgt ctagcctgac cagcgatgat agcgcggtgt attattgcgc gcgtgattat      300

gataacgcgt attggggtca gggcaccacg gtcaccgtct cctca                      345


<210>  11
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      


Glu Arg Val Thr Leu Thr Cys Lys Ala Ser Glu Asn Ala Gly Thr Tyr 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asn Gly Ser His Arg Tyr Asp Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Asp Tyr Tyr Cys Gly Gln Ser Tyr Ser Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  12
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12
aacattgtga tgacccagag cccgaaaagc atgagcatga gcgtgggcga acgtgtgacc       60

ctgacctgca aagcgagcga gaacgctggc acctatgttg cgtggtatca gcagaaaccg      120

gaacagtctc cgaaactgct gatctataat gggagccacc ggtatgacgg cgtgccggat      180

cgttttaccg gcagcggcag cgcgaccgat ttcaccctga ccattagcag cgtgcaggcg      240

gaagatctgg cggattatta ctgcggccag agctatagct atccgtggac ctttggcggt      300

gggaccaagc tggaaatgaa acgggctgat gcggcgccaa ctgtatccat cttcccacca      360

tccagtgagc agttaacatc tggaggtgcc tcagtcgtgt gcttcttgaa caacttctac      420

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      480

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      540

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      600

tcaacttcac ccattgtcaa gagcttcaac aggaatgagt gt                         642


<210>  13
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Gln Val Gln Leu Leu Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Asn Phe Asn Asp Tyr 
            20                  25                  30          


Trp Leu Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ala Tyr Pro Gly Trp Gly Ile Ile Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Ser Lys Val Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Val Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Tyr Asp Asn Ala Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys 
    210                 215                 220                 


Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val Asp 
            260                 265                 270         


Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln Phe 
        275                 280                 285             


Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala Phe 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro Lys 
                325                 330                 335     


Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala Lys 
            340                 345                 350         


Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu Asp 
        355                 360                 365             


Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr Lys 
    370                 375                 380                 


Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr Ser 
385                 390                 395                 400 


Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe Thr 
                405                 410                 415     


Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys Ser 
            420                 425                 430         


Leu Ser His Ser Pro Gly Lys 
        435                 


<210>  14
<211>  1317
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14
caggtgcagc tgctgcagcc gggtgccgaa ctggttaaac cgggtgccag cgtgaaactg       60

agctgcaaag cgagcggcta taacttcaac gactattggc ttaactgggt gaaacagcgt      120

ccgggccagg gcctggaatg gattggcaat gcctatccgg gctggggcat cattaactat      180

aacgaaaaat tcaaaagcaa agtgaccctg accgtggata ccagcagcag caccgtgtat      240

atgcagctgt ctagcctgac cagcgatgat agcgcggtgt attattgcgc gcgtgattat      300

gataacgcgt attggggtca gggcaccacg gtcaccgtct cctcagccaa aacgacaccc      360

ccatctgtct atccgctagc ccctggatct gccgcccaga ccaacagcat ggtgaccctg      420

ggctgtctgg tgaagggcta cttccctgag cctgtgacag tgacctggaa cagcggctct      480

ctgtctagcg gcgtgcacac attccctgcc gtgctgcaga gcgacctgta caccctgagc      540

agcagcgtga ccgtgcctag cagcacatgg cctagcgaga ccgtgacatg caacgtggcc      600

caccctgcct cttctaccaa ggtggacaag aagatcgtgc ccagagactg cggctgcaag      660

ccttgcatct gcaccgtgcc tgaggtgagc agcgtgttca tcttcccacc caagcccaag      720

gacgtgctca ccatcaccct cacccccaag gtcacgtgtg ttgtggtaga catcagcaag      780

gatgatcccg aggtccagtt cagctggttt gtagatgatg tggaggtgca cacagctcag      840

acgcaacccc gggaggagca gttcaacagc actttccgct cagtcagtga acttcccatc      900

atgcaccagg actggctcaa tggcaaggag ttcaaatgca gggtcaacag tgcagctttc      960

cctgccccca tcgagaaaac catctccaaa accaaaggca gaccgaaggc tccacaggtg     1020

tacaccattc cacctcccaa ggagcagatg gccaaggata aagtcagtct gacctgcatg     1080

ataacagact tcttccctga agacattact gtggagtggc agtggaatgg gcagccagcg     1140

gagaactaca agaacactca gcccatcatg gacacagatg gctcttactt cgtctacagc     1200

aagctcaatg tgcagaagag caactgggag gcaggaaata ctttcacctg ctctgtgtta     1260

catgagggcc tgcacaacca ccatactgag aagagcctct cccactctcc tggtaaa        1317


<210>  15
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Arg Ser Pro Lys Ser Leu Val Gly Pro Met Gly Arg Thr Tyr Leu Tyr 
1               5                   10                  15      


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Arg Arg Asn Asn Leu Ala Pro 
1               5           


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Met Gln His Leu Glu Phe Pro Leu Thr 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Gly Tyr Asn Phe Thr Asp Tyr Trp Ile His 
1               5                   10  


<210>  19
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Tyr Phe Ser Thr His Ser Asp Tyr Ala Ile Ile Asn Gln Lys Phe Arg 
1               5                   10                  15      


Asp 
    


<210>  20
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gly Gly Leu Gly Leu Ser Tyr 
1               5           


<210>  21
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Leu Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Pro Lys Ser Leu Val Gly Pro 
            20                  25                  30          


Met Gly Arg Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Arg Asn Asn Leu Ala Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  22
<211>  339
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22
gatattgtga tgacccaggc agcgccgagc gttctggtta ccccgggtga aagcgtgagc       60

attagctgcc gaagcccaaa aagcctagtg ggtcccatgg gaaggaccta tctatattgg      120

tttctgcagc gtccgggtca gagcccgcag ctgctgattt atcgtcggaa caacctggca      180

ccaggtgtgc cggatcgttt tagcggcagc ggtagcggca ccgcgtttac cctgcgtatt      240

agccgtgtgg aagcggaaga tgtgggcatt tattattgca tgcagcacct ggaattcccg      300

ctgacctttg gtgcgggcac caagctggaa atcaaacgg                             339


<210>  23
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Ser Thr His Ser Asp Tyr Ala Ile Ile Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Arg Leu Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Gly Leu Ser Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  24
<211>  348
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24
caggtgcagc tgcagcagag cggtgcggaa ctggtgaaac cgggtgcgag cgtgaaaatg       60

agctgcaaag cgagcggcta taactttaca gattattgga ttcactgggt gaaagaacgt      120

ccgggccagg gcctggaatg gattggctat tttagtacgc atagcgatta tgccatcatt      180

aaccagaaat tcagagataa agcgaccctg accgcggata aaagcagccg tctggcctat      240

atgcagctgt ctagcctgac cagcgaagat agcgcgattt attactgcgc gcgtggcggc      300

ttaggcctga gctattgggg ccagggtacc acggtcacag tctcctca                   348


<210>  25
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Leu Val Thr Pro Gly 
1               5                   10                  15      


Glu Ser Val Ser Ile Ser Cys Arg Ser Pro Lys Ser Leu Val Gly Pro 
            20                  25                  30          


Met Gly Arg Thr Tyr Leu Tyr Trp Phe Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Arg Arg Asn Asn Leu Ala Pro Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe Thr Leu Arg Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Ile Tyr Tyr Cys Met Gln His 
                85                  90                  95      


Leu Glu Phe Pro Leu Thr Phe Gly Ala Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  26
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26
gatattgtga tgacccaggc agcgccgagc gttctggtta ccccgggtga aagcgtgagc       60

attagctgcc gaagcccaaa aagcctagtg ggtcccatgg gaaggaccta tctatattgg      120

tttctgcagc gtccgggtca gagcccgcag ctgctgattt atcgtcggaa caacctggca      180

ccaggtgtgc cggatcgttt tagcggcagc ggtagcggca ccgcgtttac cctgcgtatt      240

agccgtgtgg aagcggaaga tgtgggcatt tattattgca tgcagcacct ggaattcccg      300

ctgacctttg gtgcgggcac caagctggaa atcaaacggg ctgatgcggc gcccactgta      360

tccatcttcc caccatccag tgagcagtta acatctggag gtgctagcgt cgtgtgcttc      420

ttgaacaact tctaccccaa agacatcaat gtcaagtgga agattgatgg cagtgaacga      480

caaaatggcg tcctgaacag ttggactgat caggacagca aagacagcac ctacagcatg      540

agcagcaccc tcacgttgac caaggacgag tatgaacgac ataacagcta tacctgtgag      600

gccactcaca agacatcaac ttcacccatt gtcaagagct tcaacaggaa tgagtgt         657


<210>  27
<211>  440
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Asn Phe Thr Asp Tyr 
            20                  25                  30          


Trp Ile His Trp Val Lys Glu Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Phe Ser Thr His Ser Asp Tyr Ala Ile Ile Asn Gln Lys Phe 
    50                  55                  60                  


Arg Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Arg Leu Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Gly Leu Gly Leu Ser Tyr Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala 
        115                 120                 125             


Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly 
145                 150                 155                 160 


Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp 
                165                 170                 175     


Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro 
            180                 185                 190         


Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile 
    210                 215                 220                 


Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys Pro 
225                 230                 235                 240 


Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val Val 
                245                 250                 255     


Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe Val 
            260                 265                 270         


Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu Gln 
        275                 280                 285             


Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His Gln 
    290                 295                 300                 


Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala Ala 
305                 310                 315                 320 


Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg Pro 
                325                 330                 335     


Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met Ala 
            340                 345                 350         


Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro Glu 
        355                 360                 365             


Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn Tyr 
    370                 375                 380                 


Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val Tyr 
385                 390                 395                 400 


Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr Phe 
                405                 410                 415     


Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu Lys 
            420                 425                 430         


Ser Leu Ser His Ser Pro Gly Lys 
        435                 440 


<210>  28
<211>  1320
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28
caggtgcagc tgcagcagag cggtgcggaa ctggtgaaac cgggtgcgag cgtgaaaatg       60

agctgcaaag cgagcggcta taactttaca gattattgga ttcactgggt gaaagaacgt      120

ccgggccagg gcctggaatg gattggctat tttagtacgc atagcgatta tgccatcatt      180

aaccagaaat tcagagataa agcgaccctg accgcggata aaagcagccg tctggcctat      240

atgcagctgt ctagcctgac cagcgaagat agcgcgattt attactgcgc gcgtggcggc      300

ttaggcctga gctattgggg ccagggtacc acggtcacag tctcctcagc caaaacgaca      360

cccccatctg tctatccgct agcccctgga tctgccgccc agaccaacag catggtgacc      420

ctgggctgtc tggtgaaggg ctacttccct gagcctgtga cagtgacctg gaacagcggc      480

tctctgtcta gcggcgtgca cacattccct gccgtgctgc agagcgacct gtacaccctg      540

agcagcagcg tgaccgtgcc tagcagcaca tggcctagcg agaccgtgac atgcaacgtg      600

gcccaccctg cctcttctac caaggtggac aagaagatcg tgcccagaga ctgcggctgc      660

aagccttgca tctgcaccgt gcctgaggtg agcagcgtgt tcatcttccc acccaagccc      720

aaggacgtgc tcaccatcac cctcaccccc aaggtcacgt gtgttgtggt agacatcagc      780

aaggatgatc ccgaggtcca gttcagctgg tttgtagatg atgtggaggt gcacacagct      840

cagacgcaac cccgggagga gcagttcaac agcactttcc gctcagtcag tgaacttccc      900

atcatgcacc aggactggct caatggcaag gagttcaaat gcagggtcaa cagtgcagct      960

ttccctgccc ccatcgagaa aaccatctcc aaaaccaaag gcagaccgaa ggctccacag     1020

gtgtacacca ttccacctcc caaggagcag atggccaagg ataaagtcag tctgacctgc     1080

atgataacag acttcttccc tgaagacatt actgtggagt ggcagtggaa tgggcagcca     1140

gcggagaact acaagaacac tcagcccatc atggacacag atggctctta cttcgtctac     1200

agcaagctca atgtgcagaa gagcaactgg gaggcaggaa atactttcac ctgctctgtg     1260

ttacatgagg gcctgcacaa ccaccatact gagaagagcc tctcccactc tcctggtaaa     1320


<210>  29
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  29

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


