                         SEQUENCE LISTING

<110>  Bergen Teknologioverforing AS
 
<120>  Marker and method for diagnosing diarrhea syndrome

<130>  4200-019-PCT-1

<150>  EP11191486
<151>  2011-12-01

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  48
<212>  DNA
<213>  homo sapiens

<400>  1
ttcactacta tctgcaaata catcaccccc atggaagtgg tggacatg                    48


<210>  2
<211>  3713
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(3222)

<400>  2
atg aag acg ttg ctg ttg gac ttg gct ttg tgg tca ctg ctc ttc cag         48
Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln           
1               5                   10                  15                

ccc ggg tgg ctg tcc ttt agt tcc cag gtg agt cag aac tgc cac aat         96
Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn           
            20                  25                  30                    

ggc agc tat gaa atc agc gtc ctg atg atg ggc aac tca gcc ttt gca        144
Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala           
        35                  40                  45                        

gag ccc ctg aaa aac ttg gaa gat gcg gtg aat gag ggg ctg gaa ata        192
Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile           
    50                  55                  60                            

gtg aga gga cgt ctg caa aat gct ggc cta aat gtg act gtg aac gct        240
Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala           
65                  70                  75                  80            

act ttc atg tat tcg gat ggt ctg att cat aac tca ggc gac tgc cgg        288
Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg           
                85                  90                  95                

agt agc acc tgt gaa ggc ctc gac cta ctc agg aaa att tca aat gca        336
Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala           
            100                 105                 110                   

caa cgg atg ggc tgt gtc ctc ata ggg ccc tca tgt aca tac tcc acc        384
Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr           
        115                 120                 125                       

ttc cag atg tac ctt gac aca gaa ttg agc tac ccc atg atc tca gct        432
Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala           
    130                 135                 140                           

gga agt ttt gga ttg tca tgt gac tat aaa gaa acc tta acc agg ctg        480
Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu           
145                 150                 155                 160           

atg tct cca gct aga aag ttg atg tac ttc ttg gtt aac ttt tgg aaa        528
Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys           
                165                 170                 175               

acc aac gat ctg ccc ttc aaa act tat tcc tgg agc act tcg tat gtt        576
Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val           
            180                 185                 190                   

tac aag aat ggt aca gaa act gag gac tgt ttc tgg tac ctt aat gct        624
Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala           
        195                 200                 205                       

ctg gag gct agc gtt tcc tat ttc tcc cac gaa ctc ggc ttt aag gtg        672
Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val           
    210                 215                 220                           

gtg tta aga caa gat aag gag ttt cag gat atc tta atg gac cac aac        720
Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn           
225                 230                 235                 240           

agg aaa agc aat gtg att att atg tgt ggt ggt cca gag ttc ctc tac        768
Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr           
                245                 250                 255               

aag ctg aag ggt gac cga gca gtg gct gaa gac att gtc att att cta        816
Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu           
            260                 265                 270                   

gtg gat ctt ttc aat gac cag tac ttt gag gac aat gtc aca gcc cct        864
Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro           
        275                 280                 285                       

gac tat atg aaa aat gtc ctt gtt ctg acg ctg tct cct ggg aat tcc        912
Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser           
    290                 295                 300                           

ctt cta aat agc tct ttc tcc agg aat cta tca cca aca aaa cga gac        960
Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp           
305                 310                 315                 320           

ttt gct ctt gcc tat ttg aat gga atc ctg ctc ttt gga cat atg ctg       1008
Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu           
                325                 330                 335               

aag ata ttt ctt gaa aat gga gaa aat att acc acc ccc aaa ttt gct       1056
Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala           
            340                 345                 350                   

cat gct ttc agg aat ctc act ttt gaa ggg tat gac ggt cca gtg acc       1104
His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr           
        355                 360                 365                       

ttg gat gac tgg ggg gat gtt gac agt acc atg gtg ctt ctg tat acc       1152
Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr           
    370                 375                 380                           

tct gtg gac acc aag aaa tac aag gtt ctt ttg acc tat gat acc cac       1200
Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His           
385                 390                 395                 400           

gta aat aag acc tat cct gtg gat atg agc ccc aca ttc act tgg aag       1248
Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys           
                405                 410                 415               

aac tct aaa ctt cct aat gat att aca ggc cgg ggc cct cag atc ctg       1296
Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu           
            420                 425                 430                   

atg att gca gtc ttc acc ctc act gga gct gtg gtg ctg ctc ctg ctc       1344
Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu           
        435                 440                 445                       

gtc gct ctc ctg atg ctc aga aaa tat aga aaa gat tat gaa ctt cgt       1392
Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg           
    450                 455                 460                           

cag aaa aaa tgg tcc cac att cct cct gaa aat atc ttt cct ctg gag       1440
Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu           
465                 470                 475                 480           

acc aat gag acc aat cat gtt agc ctc aag atc gat gat gac aaa aga       1488
Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg           
                485                 490                 495               

cga gat aca atc cag aga cta cga cag tgc aaa tac gac aaa aag cga       1536
Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg           
            500                 505                 510                   

gtg att ctc aaa gat ctc aag cac aat gat ggt aat ttc act gaa aaa       1584
Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys           
        515                 520                 525                       

cag aag ata gaa ttg aac aag ttg ctt cag att gac tat tac aac ctg       1632
Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu           
    530                 535                 540                           

acc aag ttc tac ggc aca gtg aaa ctt gat acc atg atc ttc ggg gtg       1680
Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val           
545                 550                 555                 560           

ata gaa tac tgt gag aga gga tcc ctc cgg gaa gtt tta aat gac aca       1728
Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr           
                565                 570                 575               

att tcc tac cct gat ggc aca ttc atg gat tgg gag ttt aag atc tct       1776
Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser           
            580                 585                 590                   

gtc ttg tat gac att gct aag gga atg tca tat ctg cac tcc agt aag       1824
Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys           
        595                 600                 605                       

aca gaa gtc cat ggt cgt ctg aaa tct acc aac tgc gta gtg gac agt       1872
Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser           
    610                 615                 620                           

aga atg gtg gtg aag atc act gat ttt ggc tgc aat tcc att tta cct       1920
Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro           
625                 630                 635                 640           

cca aaa aag gac ctg tgg aca gct cca gag cac ctc cgc caa gcc aac       1968
Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn           
                645                 650                 655               

atc tct cag aaa gga gat gtg tac agc tat ggg atc atc gca cag gag       2016
Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu           
            660                 665                 670                   

atc atc ctg cgg aaa gaa acc ttc tac act ttg agc tgt cgg gac cgg       2064
Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg           
        675                 680                 685                       

aat gag aag att ttc aga gtg gaa aat tcc aat gga atg aaa ccc ttc       2112
Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe           
    690                 695                 700                           

cgc cca gat tta ttc ttg gaa aca gca gag gaa aaa gag cta gaa gtg       2160
Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val           
705                 710                 715                 720           

tac cta ctt gta aaa aac tgt tgg gag gaa gat cca gaa aag aga cca       2208
Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro           
                725                 730                 735               

gat ttc aaa aaa att gag act aca ctt gcc aag ata ttt gga ctt ttt       2256
Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe           
            740                 745                 750                   

cat gac caa aaa aat gaa agc tat atg gat acc ttg atc cga cgt cta       2304
His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu           
        755                 760                 765                       

cag cta tat tct cga aac ctg gaa cat ctg gta gag gaa agg aca cag       2352
Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln           
    770                 775                 780                           

ctg tac aag gca gag agg gac agg gct gac aga ctt aac ttt atg ttg       2400
Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu           
785                 790                 795                 800           

ctt cca agg cta gtg gta aag tct ctg aag gag aaa ggc ttt gtg gag       2448
Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu           
                805                 810                 815               

ccg gaa cta tat gag gaa gtt aca atc tac ttc agt gac att gta ggt       2496
Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly           
            820                 825                 830                   

ttc act act atc tgc aaa tac atc acc ccc atg gaa gtg gtg gac atg       2544
Phe Thr Thr Ile Cys Lys Tyr Ile Thr Pro Met Glu Val Val Asp Met           
        835                 840                 845                       

ctt aat gac atc tat aag agt ttt gac cac att gtt gat cat cat gat       2592
Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp           
    850                 855                 860                           

gtc tac aag gtg gaa acc atc ggt gat gcg tac atg gtg gct agt ggt       2640
Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly           
865                 870                 875                 880           

ttg cct aag aga aat ggc aat cgg cat gca ata gac att gcc aag atg       2688
Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met           
                885                 890                 895               

gcc ttg gaa atc ctc agc ttc atg ggg acc ttt gag ctg gag cat ctt       2736
Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu           
            900                 905                 910                   

cct ggc ctc cca ata tgg att cgc att gga gtt cac tct ggt ccc tgt       2784
Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys           
        915                 920                 925                       

gct gct gga gtt gtg gga atc aag atg cct cgt tat tgt cta ttt gga       2832
Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly           
    930                 935                 940                           

gat acg gtc aac aca gcc tct agg atg gaa tcc act ggc ctc cct ttg       2880
Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu           
945                 950                 955                 960           

aga att cac gtg agt ggc tcc acc ata gcc atc ctg aag aga act gag       2928
Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu           
                965                 970                 975               

tgc cag ttc ctt tat gaa gtg aga gga gaa aca tac tta aag gga aga       2976
Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg           
            980                 985                 990                   

gga aat gag act acc tac tgg ctg  act ggg atg aag gac  cag aaa ttc     3024
Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe         
        995                 1000                 1005                     

aac ctg  cca acc cct cct act  gtg gag aat caa cag  cgt ttg caa        3069
Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln            
    1010                 1015                 1020                        

gca gaa  ttt tca gac atg att  gcc aac tct tta cag  aaa aga cag        3114
Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln            
    1025                 1030                 1035                        

gca gca  ggg ata aga agc caa  aaa ccc aga cgg gta  gcc agc tat        3159
Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr            
    1040                 1045                 1050                        

aaa aaa  ggc act ctg gaa tac  ttg cag ctg aat acc  aca gac aag        3204
Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys            
    1055                 1060                 1065                        

gag agc  acc tat ttt taa acctaaatga ggtataagga ctcacacaaa             3252
Glu Ser  Thr Tyr Phe                                                      
    1070                                                                  

ttaaaataca gctgcactga ggcagcgacc tcaagtgtcc tgaaagctta cattttcctg     3312

agacctcaat gaagcagaaa tgtacttagg cttggctgcc ctgtctggaa catggacttt     3372

cttgcatgaa tcagatgtgt gttctcagtg aaataactac cttccactct ggaaccttat     3432

tccagcagtt gttccaggga gcttctacct ggaaaagaaa agaaatgaat agactatcta     3492

gaacttgaga agattttatt cttatttcat ttattttttg tttgtttatt tttatcgttt     3552

ttgtttactg gctttccttc tgtattcata agatttttta aattgtcata attatatttt     3612

aaatacccat cttcattaaa gtatatttaa ctcataattt ttgcagaaaa tatgctatat     3672

attaggcaag aataaaagct aaaggtttcc caaaaaaaaa a                         3713


<210>  3
<211>  1073
<212>  PRT
<213>  homo sapiens

<400>  3

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ile Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210>  4
<211>  3713
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(3222)

<400>  4
atg aag acg ttg ctg ttg gac ttg gct ttg tgg tca ctg ctc ttc cag         48
Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln           
1               5                   10                  15                

ccc ggg tgg ctg tcc ttt agt tcc cag gtg agt cag aac tgc cac aat         96
Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn           
            20                  25                  30                    

ggc agc tat gaa atc agc gtc ctg atg atg ggc aac tca gcc ttt gca        144
Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala           
        35                  40                  45                        

gag ccc ctg aaa aac ttg gaa gat gcg gtg aat gag ggg ctg gaa ata        192
Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile           
    50                  55                  60                            

gtg aga gga cgt ctg caa aat gct ggc cta aat gtg act gtg aac gct        240
Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala           
65                  70                  75                  80            

act ttc atg tat tcg gat ggt ctg att cat aac tca ggc gac tgc cgg        288
Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg           
                85                  90                  95                

agt agc acc tgt gaa ggc ctc gac cta ctc agg aaa att tca aat gca        336
Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala           
            100                 105                 110                   

caa cgg atg ggc tgt gtc ctc ata ggg ccc tca tgt aca tac tcc acc        384
Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr           
        115                 120                 125                       

ttc cag atg tac ctt gac aca gaa ttg agc tac ccc atg atc tca gct        432
Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala           
    130                 135                 140                           

gga agt ttt gga ttg tca tgt gac tat aaa gaa acc tta acc agg ctg        480
Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu           
145                 150                 155                 160           

atg tct cca gct aga aag ttg atg tac ttc ttg gtt aac ttt tgg aaa        528
Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys           
                165                 170                 175               

acc aac gat ctg ccc ttc aaa act tat tcc tgg agc act tcg tat gtt        576
Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val           
            180                 185                 190                   

tac aag aat ggt aca gaa act gag gac tgt ttc tgg tac ctt aat gct        624
Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala           
        195                 200                 205                       

ctg gag gct agc gtt tcc tat ttc tcc cac gaa ctc ggc ttt aag gtg        672
Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val           
    210                 215                 220                           

gtg tta aga caa gat aag gag ttt cag gat atc tta atg gac cac aac        720
Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn           
225                 230                 235                 240           

agg aaa agc aat gtg att att atg tgt ggt ggt cca gag ttc ctc tac        768
Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr           
                245                 250                 255               

aag ctg aag ggt gac cga gca gtg gct gaa gac att gtc att att cta        816
Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu           
            260                 265                 270                   

gtg gat ctt ttc aat gac cag tac ttt gag gac aat gtc aca gcc cct        864
Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro           
        275                 280                 285                       

gac tat atg aaa aat gtc ctt gtt ctg acg ctg tct cct ggg aat tcc        912
Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser           
    290                 295                 300                           

ctt cta aat agc tct ttc tcc agg aat cta tca cca aca aaa cga gac        960
Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp           
305                 310                 315                 320           

ttt gct ctt gcc tat ttg aat gga atc ctg ctc ttt gga cat atg ctg       1008
Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu           
                325                 330                 335               

aag ata ttt ctt gaa aat gga gaa aat att acc acc ccc aaa ttt gct       1056
Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala           
            340                 345                 350                   

cat gct ttc agg aat ctc act ttt gaa ggg tat gac ggt cca gtg acc       1104
His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr           
        355                 360                 365                       

ttg gat gac tgg ggg gat gtt gac agt acc atg gtg ctt ctg tat acc       1152
Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr           
    370                 375                 380                           

tct gtg gac acc aag aaa tac aag gtt ctt ttg acc tat gat acc cac       1200
Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His           
385                 390                 395                 400           

gta aat aag acc tat cct gtg gat atg agc ccc aca ttc act tgg aag       1248
Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys           
                405                 410                 415               

aac tct aaa ctt cct aat gat att aca ggc cgg ggc cct cag atc ctg       1296
Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu           
            420                 425                 430                   

atg att gca gtc ttc acc ctc act gga gct gtg gtg ctg ctc ctg ctc       1344
Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu           
        435                 440                 445                       

gtc gct ctc ctg atg ctc aga aaa tat aga aaa gat tat gaa ctt cgt       1392
Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg           
    450                 455                 460                           

cag aaa aaa tgg tcc cac att cct cct gaa aat atc ttt cct ctg gag       1440
Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu           
465                 470                 475                 480           

acc aat gag acc aat cat gtt agc ctc aag atc gat gat gac aaa aga       1488
Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg           
                485                 490                 495               

cga gat aca atc cag aga cta cga cag tgc aaa tac gac aaa aag cga       1536
Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg           
            500                 505                 510                   

gtg att ctc aaa gat ctc aag cac aat gat ggt aat ttc act gaa aaa       1584
Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys           
        515                 520                 525                       

cag aag ata gaa ttg aac aag ttg ctt cag att gac tat tac aac ctg       1632
Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu           
    530                 535                 540                           

acc aag ttc tac ggc aca gtg aaa ctt gat acc atg atc ttc ggg gtg       1680
Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val           
545                 550                 555                 560           

ata gaa tac tgt gag aga gga tcc ctc cgg gaa gtt tta aat gac aca       1728
Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr           
                565                 570                 575               

att tcc tac cct gat ggc aca ttc atg gat tgg gag ttt aag atc tct       1776
Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser           
            580                 585                 590                   

gtc ttg tat gac att gct aag gga atg tca tat ctg cac tcc agt aag       1824
Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys           
        595                 600                 605                       

aca gaa gtc cat ggt cgt ctg aaa tct acc aac tgc gta gtg gac agt       1872
Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser           
    610                 615                 620                           

aga atg gtg gtg aag atc act gat ttt ggc tgc aat tcc att tta cct       1920
Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro           
625                 630                 635                 640           

cca aaa aag gac ctg tgg aca gct cca gag cac ctc cgc caa gcc aac       1968
Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn           
                645                 650                 655               

atc tct cag aaa gga gat gtg tac agc tat ggg atc atc gca cag gag       2016
Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu           
            660                 665                 670                   

atc atc ctg cgg aaa gaa acc ttc tac act ttg agc tgt cgg gac cgg       2064
Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg           
        675                 680                 685                       

aat gag aag att ttc aga gtg gaa aat tcc aat gga atg aaa ccc ttc       2112
Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe           
    690                 695                 700                           

cgc cca gat tta ttc ttg gaa aca gca gag gaa aaa gag cta gaa gtg       2160
Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val           
705                 710                 715                 720           

tac cta ctt gta aaa aac tgt tgg gag gaa gat cca gaa aag aga cca       2208
Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro           
                725                 730                 735               

gat ttc aaa aaa att gag act aca ctt gcc aag ata ttt gga ctt ttt       2256
Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe           
            740                 745                 750                   

cat gac caa aaa aat gaa agc tat atg gat acc ttg atc cga cgt cta       2304
His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu           
        755                 760                 765                       

cag cta tat tct cga aac ctg gaa cat ctg gta gag gaa agg aca cag       2352
Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln           
    770                 775                 780                           

ctg tac aag gca gag agg gac agg gct gac aga ctt aac ttt atg ttg       2400
Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu           
785                 790                 795                 800           

ctt cca agg cta gtg gta aag tct ctg aag gag aaa ggc ttt gtg gag       2448
Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu           
                805                 810                 815               

ccg gaa cta tat gag gaa gtt aca atc tac ttc agt gac att gta ggt       2496
Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly           
            820                 825                 830                   

ttc act act atc tgc aaa tac agc acc ccc atg gaa gtg gtg gac atg       2544
Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met           
        835                 840                 845                       

ctt aat gac atc tat aag agt ttt gac cac att gtt gat cat cat gat       2592
Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp           
    850                 855                 860                           

gtc tac aag gtg gaa acc atc ggt gat gcg tac atg gtg gct agt ggt       2640
Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly           
865                 870                 875                 880           

ttg cct aag aga aat ggc aat cgg cat gca ata gac att gcc aag atg       2688
Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met           
                885                 890                 895               

gcc ttg gaa atc ctc agc ttc atg ggg acc ttt gag ctg gag cat ctt       2736
Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu           
            900                 905                 910                   

cct ggc ctc cca ata tgg att cgc att gga gtt cac tct ggt ccc tgt       2784
Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys           
        915                 920                 925                       

gct gct gga gtt gtg gga atc aag atg cct cgt tat tgt cta ttt gga       2832
Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly           
    930                 935                 940                           

gat acg gtc aac aca gcc tct agg atg gaa tcc act ggc ctc cct ttg       2880
Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu           
945                 950                 955                 960           

aga att cac gtg agt ggc tcc acc ata gcc atc ctg aag aga act gag       2928
Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu           
                965                 970                 975               

tgc cag ttc ctt tat gaa gtg aga gga gaa aca tac tta aag gga aga       2976
Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg           
            980                 985                 990                   

gga aat gag act acc tac tgg ctg  act ggg atg aag gac  cag aaa ttc     3024
Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe         
        995                 1000                 1005                     

aac ctg  cca acc cct cct act  gtg gag aat caa cag  cgt ttg caa        3069
Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln            
    1010                 1015                 1020                        

gca gaa  ttt tca gac atg att  gcc aac tct tta cag  aaa aga cag        3114
Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln            
    1025                 1030                 1035                        

gca gca  ggg ata aga agc caa  aaa ccc aga cgg gta  gcc agc tat        3159
Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr            
    1040                 1045                 1050                        

aaa aaa  ggc act ctg gaa tac  ttg cag ctg aat acc  aca gac aag        3204
Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys            
    1055                 1060                 1065                        

gag agc  acc tat ttt taa acctaaatga ggtataagga ctcacacaaa             3252
Glu Ser  Thr Tyr Phe                                                      
    1070                                                                  

ttaaaataca gctgcactga ggcagcgacc tcaagtgtcc tgaaagctta cattttcctg     3312

agacctcaat gaagcagaaa tgtacttagg cttggctgcc ctgtctggaa catggacttt     3372

cttgcatgaa tcagatgtgt gttctcagtg aaataactac cttccactct ggaaccttat     3432

tccagcagtt gttccaggga gcttctacct ggaaaagaaa agaaatgaat agactatcta     3492

gaacttgaga agattttatt cttatttcat ttattttttg tttgtttatt tttatcgttt     3552

ttgtttactg gctttccttc tgtattcata agatttttta aattgtcata attatatttt     3612

aaatacccat cttcattaaa gtatatttaa ctcataattt ttgcagaaaa tatgctatat     3672

attaggcaag aataaaagct aaaggtttcc caaaaaaaaa a                         3713


<210>  5
<211>  1073
<212>  PRT
<213>  homo sapiens

<400>  5

Met Lys Thr Leu Leu Leu Asp Leu Ala Leu Trp Ser Leu Leu Phe Gln 
1               5                   10                  15      


Pro Gly Trp Leu Ser Phe Ser Ser Gln Val Ser Gln Asn Cys His Asn 
            20                  25                  30          


Gly Ser Tyr Glu Ile Ser Val Leu Met Met Gly Asn Ser Ala Phe Ala 
        35                  40                  45              


Glu Pro Leu Lys Asn Leu Glu Asp Ala Val Asn Glu Gly Leu Glu Ile 
    50                  55                  60                  


Val Arg Gly Arg Leu Gln Asn Ala Gly Leu Asn Val Thr Val Asn Ala 
65                  70                  75                  80  


Thr Phe Met Tyr Ser Asp Gly Leu Ile His Asn Ser Gly Asp Cys Arg 
                85                  90                  95      


Ser Ser Thr Cys Glu Gly Leu Asp Leu Leu Arg Lys Ile Ser Asn Ala 
            100                 105                 110         


Gln Arg Met Gly Cys Val Leu Ile Gly Pro Ser Cys Thr Tyr Ser Thr 
        115                 120                 125             


Phe Gln Met Tyr Leu Asp Thr Glu Leu Ser Tyr Pro Met Ile Ser Ala 
    130                 135                 140                 


Gly Ser Phe Gly Leu Ser Cys Asp Tyr Lys Glu Thr Leu Thr Arg Leu 
145                 150                 155                 160 


Met Ser Pro Ala Arg Lys Leu Met Tyr Phe Leu Val Asn Phe Trp Lys 
                165                 170                 175     


Thr Asn Asp Leu Pro Phe Lys Thr Tyr Ser Trp Ser Thr Ser Tyr Val 
            180                 185                 190         


Tyr Lys Asn Gly Thr Glu Thr Glu Asp Cys Phe Trp Tyr Leu Asn Ala 
        195                 200                 205             


Leu Glu Ala Ser Val Ser Tyr Phe Ser His Glu Leu Gly Phe Lys Val 
    210                 215                 220                 


Val Leu Arg Gln Asp Lys Glu Phe Gln Asp Ile Leu Met Asp His Asn 
225                 230                 235                 240 


Arg Lys Ser Asn Val Ile Ile Met Cys Gly Gly Pro Glu Phe Leu Tyr 
                245                 250                 255     


Lys Leu Lys Gly Asp Arg Ala Val Ala Glu Asp Ile Val Ile Ile Leu 
            260                 265                 270         


Val Asp Leu Phe Asn Asp Gln Tyr Phe Glu Asp Asn Val Thr Ala Pro 
        275                 280                 285             


Asp Tyr Met Lys Asn Val Leu Val Leu Thr Leu Ser Pro Gly Asn Ser 
    290                 295                 300                 


Leu Leu Asn Ser Ser Phe Ser Arg Asn Leu Ser Pro Thr Lys Arg Asp 
305                 310                 315                 320 


Phe Ala Leu Ala Tyr Leu Asn Gly Ile Leu Leu Phe Gly His Met Leu 
                325                 330                 335     


Lys Ile Phe Leu Glu Asn Gly Glu Asn Ile Thr Thr Pro Lys Phe Ala 
            340                 345                 350         


His Ala Phe Arg Asn Leu Thr Phe Glu Gly Tyr Asp Gly Pro Val Thr 
        355                 360                 365             


Leu Asp Asp Trp Gly Asp Val Asp Ser Thr Met Val Leu Leu Tyr Thr 
    370                 375                 380                 


Ser Val Asp Thr Lys Lys Tyr Lys Val Leu Leu Thr Tyr Asp Thr His 
385                 390                 395                 400 


Val Asn Lys Thr Tyr Pro Val Asp Met Ser Pro Thr Phe Thr Trp Lys 
                405                 410                 415     


Asn Ser Lys Leu Pro Asn Asp Ile Thr Gly Arg Gly Pro Gln Ile Leu 
            420                 425                 430         


Met Ile Ala Val Phe Thr Leu Thr Gly Ala Val Val Leu Leu Leu Leu 
        435                 440                 445             


Val Ala Leu Leu Met Leu Arg Lys Tyr Arg Lys Asp Tyr Glu Leu Arg 
    450                 455                 460                 


Gln Lys Lys Trp Ser His Ile Pro Pro Glu Asn Ile Phe Pro Leu Glu 
465                 470                 475                 480 


Thr Asn Glu Thr Asn His Val Ser Leu Lys Ile Asp Asp Asp Lys Arg 
                485                 490                 495     


Arg Asp Thr Ile Gln Arg Leu Arg Gln Cys Lys Tyr Asp Lys Lys Arg 
            500                 505                 510         


Val Ile Leu Lys Asp Leu Lys His Asn Asp Gly Asn Phe Thr Glu Lys 
        515                 520                 525             


Gln Lys Ile Glu Leu Asn Lys Leu Leu Gln Ile Asp Tyr Tyr Asn Leu 
    530                 535                 540                 


Thr Lys Phe Tyr Gly Thr Val Lys Leu Asp Thr Met Ile Phe Gly Val 
545                 550                 555                 560 


Ile Glu Tyr Cys Glu Arg Gly Ser Leu Arg Glu Val Leu Asn Asp Thr 
                565                 570                 575     


Ile Ser Tyr Pro Asp Gly Thr Phe Met Asp Trp Glu Phe Lys Ile Ser 
            580                 585                 590         


Val Leu Tyr Asp Ile Ala Lys Gly Met Ser Tyr Leu His Ser Ser Lys 
        595                 600                 605             


Thr Glu Val His Gly Arg Leu Lys Ser Thr Asn Cys Val Val Asp Ser 
    610                 615                 620                 


Arg Met Val Val Lys Ile Thr Asp Phe Gly Cys Asn Ser Ile Leu Pro 
625                 630                 635                 640 


Pro Lys Lys Asp Leu Trp Thr Ala Pro Glu His Leu Arg Gln Ala Asn 
                645                 650                 655     


Ile Ser Gln Lys Gly Asp Val Tyr Ser Tyr Gly Ile Ile Ala Gln Glu 
            660                 665                 670         


Ile Ile Leu Arg Lys Glu Thr Phe Tyr Thr Leu Ser Cys Arg Asp Arg 
        675                 680                 685             


Asn Glu Lys Ile Phe Arg Val Glu Asn Ser Asn Gly Met Lys Pro Phe 
    690                 695                 700                 


Arg Pro Asp Leu Phe Leu Glu Thr Ala Glu Glu Lys Glu Leu Glu Val 
705                 710                 715                 720 


Tyr Leu Leu Val Lys Asn Cys Trp Glu Glu Asp Pro Glu Lys Arg Pro 
                725                 730                 735     


Asp Phe Lys Lys Ile Glu Thr Thr Leu Ala Lys Ile Phe Gly Leu Phe 
            740                 745                 750         


His Asp Gln Lys Asn Glu Ser Tyr Met Asp Thr Leu Ile Arg Arg Leu 
        755                 760                 765             


Gln Leu Tyr Ser Arg Asn Leu Glu His Leu Val Glu Glu Arg Thr Gln 
    770                 775                 780                 


Leu Tyr Lys Ala Glu Arg Asp Arg Ala Asp Arg Leu Asn Phe Met Leu 
785                 790                 795                 800 


Leu Pro Arg Leu Val Val Lys Ser Leu Lys Glu Lys Gly Phe Val Glu 
                805                 810                 815     


Pro Glu Leu Tyr Glu Glu Val Thr Ile Tyr Phe Ser Asp Ile Val Gly 
            820                 825                 830         


Phe Thr Thr Ile Cys Lys Tyr Ser Thr Pro Met Glu Val Val Asp Met 
        835                 840                 845             


Leu Asn Asp Ile Tyr Lys Ser Phe Asp His Ile Val Asp His His Asp 
    850                 855                 860                 


Val Tyr Lys Val Glu Thr Ile Gly Asp Ala Tyr Met Val Ala Ser Gly 
865                 870                 875                 880 


Leu Pro Lys Arg Asn Gly Asn Arg His Ala Ile Asp Ile Ala Lys Met 
                885                 890                 895     


Ala Leu Glu Ile Leu Ser Phe Met Gly Thr Phe Glu Leu Glu His Leu 
            900                 905                 910         


Pro Gly Leu Pro Ile Trp Ile Arg Ile Gly Val His Ser Gly Pro Cys 
        915                 920                 925             


Ala Ala Gly Val Val Gly Ile Lys Met Pro Arg Tyr Cys Leu Phe Gly 
    930                 935                 940                 


Asp Thr Val Asn Thr Ala Ser Arg Met Glu Ser Thr Gly Leu Pro Leu 
945                 950                 955                 960 


Arg Ile His Val Ser Gly Ser Thr Ile Ala Ile Leu Lys Arg Thr Glu 
                965                 970                 975     


Cys Gln Phe Leu Tyr Glu Val Arg Gly Glu Thr Tyr Leu Lys Gly Arg 
            980                 985                 990         


Gly Asn Glu Thr Thr Tyr Trp Leu  Thr Gly Met Lys Asp  Gln Lys Phe 
        995                 1000                 1005             


Asn Leu  Pro Thr Pro Pro Thr  Val Glu Asn Gln Gln  Arg Leu Gln 
    1010                 1015                 1020             


Ala Glu  Phe Ser Asp Met Ile  Ala Asn Ser Leu Gln  Lys Arg Gln 
    1025                 1030                 1035             


Ala Ala  Gly Ile Arg Ser Gln  Lys Pro Arg Arg Val  Ala Ser Tyr 
    1040                 1045                 1050             


Lys Lys  Gly Thr Leu Glu Tyr  Leu Gln Leu Asn Thr  Thr Asp Lys 
    1055                 1060                 1065             


Glu Ser  Thr Tyr Phe 
    1070             


<210>  6
<211>  50
<212>  PRT
<213>  homo sapiens

<400>  6

Asp Arg Leu Asn Phe Met Leu Leu Pro Arg Leu Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Lys Gly Phe Val Glu Pro Glu Leu Tyr Glu Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  7
<211>  50
<212>  PRT
<213>  Pan troglodytes

<400>  7

Asp Arg Leu Asn Phe Met Leu Leu Pro Arg Leu Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Lys Gly Phe Val Glu Pro Glu Leu Tyr Glu Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  8
<211>  50
<212>  PRT
<213>  Canis lupus

<400>  8

Asp Arg Leu Asn Phe Met Leu Leu Pro Arg Leu Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Lys Gly Ile Val Glu Pro Glu Leu Tyr Glu Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  9
<211>  50
<212>  PRT
<213>  bos taurus

<400>  9

Asp Gln Leu Asn Phe Met Leu Leu Pro Arg Leu Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Lys Gly Phe Val Glu Pro Glu Leu Tyr Glu Glu Val Thr Val 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  10
<211>  50
<212>  PRT
<213>  mus musculus

<400>  10

Asp His Leu Asn Phe Met Leu Leu Pro Arg Leu Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Lys Gly Ile Val Glu Pro Glu Leu Tyr Glu Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  11
<211>  50
<212>  PRT
<213>  rattus norvegicus

<400>  11

Asp His Leu Asn Phe Met Leu Leu Pro Arg Leu Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Lys Gly Ile Val Glu Pro Glu Leu Tyr Glu Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Ile Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  12
<211>  50
<212>  PRT
<213>  gallus gallus

<400>  12

Asp Arg Leu Asn Phe Met Leu Leu Pro Arg Pro Val Val Lys Ser Leu 
1               5                   10                  15      


Lys Glu Thr Gly Leu Val Glu Pro Glu Phe Phe Glu Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Leu Cys Lys Tyr Ser Thr 
        35                  40                  45              


Pro Met 
    50  


<210>  13
<211>  50
<212>  PRT
<213>  danio rerio

<400>  13

Asp Cys Leu Asn Phe Met Leu Leu Pro Gly Pro Val Val Arg Ser Leu 
1               5                   10                  15      


Lys Glu Thr Gly Lys Val Glu Pro Glu Leu Phe Asp Glu Val Thr Ile 
            20                  25                  30          


Tyr Phe Ser Asp Ile Val Gly Phe Thr Thr Leu Cys His Phe Ser Thr 
        35                  40                  45              


Pro Met 
    50  


