                         SEQUENCE LISTING

<110>  McMaster University
 
<120>  A METHOD OF PREDICTING OUTCOME IN CANCER PATIENTS

<130>  K8000973PCT

<140>  PCT CA2012/050937
<141>  2012-12-21

<150>  US 61/578927
<151>  2011-12-22

<160>  182   

<170>  PatentIn version 3.5

<210>  1
<211>  165
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ser Gly Val Gln Val Ala Asp Glu Val Cys Arg Ile Phe Tyr 
1               5                   10                  15      


Asp Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg 
            20                  25                  30          


Lys Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile 
        35                  40                  45              


Val Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile 
    50                  55                  60                  


Thr Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys 
65                  70                  75                  80  


Arg Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys 
                85                  90                  95      


Glu Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys 
            100                 105                 110         


Ser Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe 
        115                 120                 125             


Gln Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn 
    130                 135                 140                 


Arg Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe 
145                 150                 155                 160 


Glu Gly Cys Pro Val 
                165 


<210>  2
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Lys Val Arg Lys Cys Ser Thr Pro Glu Glu Ile Lys Lys Arg Lys 
1               5                   10                  15      


Lys Ala Val Ile Phe Cys Leu Ser Ala Asp Lys Lys Cys Ile Ile Val 
            20                  25                  30          


Glu Glu Gly Lys Glu Ile Leu Val Gly Asp Val Gly Val Thr Ile Thr 
        35                  40                  45              


Asp Pro Phe Lys His Phe Val Gly Met Leu Pro Glu Lys Asp Cys Arg 
    50                  55                  60                  


Tyr Ala Leu Tyr Asp Ala Ser Phe Glu Thr Lys Glu Ser Arg Lys Glu 
65                  70                  75                  80  


Glu Leu Met Phe Phe Leu Trp Ala Pro Glu Leu Ala Pro Leu Lys Ser 
                85                  90                  95      


Lys Met Ile Tyr Ala Ser Ser Lys Asp Ala Ile Lys Lys Lys Phe Gln 
            100                 105                 110         


Gly Ile Lys His Glu Cys Gln Ala Asn Gly Pro Glu Asp Leu Asn Arg 
        115                 120                 125             


Ala Cys Ile Ala Glu Lys Leu Gly Gly Ser Leu Ile Val Ala Phe Glu 
    130                 135                 140                 


Gly Cys Pro Val 
145             


<210>  3
<211>  498
<212>  DNA
<213>  Homo sapiens

<400>  3
atggcctcag gagtgcaagt agctgatgaa gtatgtcgca ttttttatga catgaaagtt       60

cgtaaatgct ccacaccaga agaaatcaag aaaagaaaga aggctgtcat tttttgtctc      120

agtgcagaca aaaagtgcat cattgtagaa gaaggcaaag agatcttggt tggagatgtt      180

ggtgtaacca taactgatcc tttcaagcat tttgtgggaa tgcttcctga aaaagattgt      240

cgctatgctt tgtatgatgc aagctttgaa acaaaagaat ccagaaaaga agagttgatg      300

ttttttttgt gggcaccaga actagcacct ctgaaaagta aaatgatcta tgcaagctcc      360

aaggatgcaa ttaaaaagaa atttcaaggc ataaaacatg aatgtcaagc aaatggacca      420

gaagatctca atcgggcttg tattgctgaa aagttaggtg gatccttaat tgtagccttt      480

gaaggatgcc ctgtgtag                                                    498


<210>  4
<211>  447
<212>  DNA
<213>  Homo sapiens

<400>  4
atgaaagttc gtaaatgctc cacaccagaa gaaatcaaga aaagaaagaa ggctgtcatt       60

ttttgtctca gtgcagacaa aaagtgcatc attgtagaag aaggcaaaga gatcttggtt      120

ggagatgttg gtgtaaccat aactgatcct ttcaagcatt ttgtgggaat gcttcctgaa      180

aaagattgtc gctatgcttt gtatgatgca agctttgaaa caaaagaatc cagaaaagaa      240

gagttgatgt tttttttgtg ggcaccagaa ctagcacctc tgaaaagtaa aatgatctat      300

gcaagctcca aggatgcaat taaaaagaaa tttcaaggca taaaacatga atgtcaagca      360

aatggaccag aagatctcaa tcgggcttgt attgctgaaa agttaggtgg atccttaatt      420

gtagcctttg aaggatgccc tgtgtag                                          447


<210>  5
<211>  651
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Leu Arg Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val 
1               5                   10                  15      


Glu Phe Ser Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr 
            20                  25                  30          


Lys Val Lys Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu 
        35                  40                  45              


Leu Asn Asp Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu 
    50                  55                  60                  


Ile Glu Lys Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser 
65                  70                  75                  80  


Asn Ile Gly Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln 
                85                  90                  95      


Lys Cys Val Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg 
            100                 105                 110         


Lys Thr Leu Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp 
        115                 120                 125             


Glu Phe Glu Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser 
    130                 135                 140                 


Lys Glu Thr Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn 
145                 150                 155                 160 


Leu Asn Met Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys 
                165                 170                 175     


Glu Lys Ser Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu 
            180                 185                 190         


Leu Val Asp Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser 
        195                 200                 205             


Lys Glu Ala Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu 
    210                 215                 220                 


Ala Ala Leu Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met 
225                 230                 235                 240 


Gly Pro Pro Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser 
                245                 250                 255     


Glu Asp Glu Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr 
            260                 265                 270         


Leu Phe Asp Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu 
        275                 280                 285             


Pro Lys Ser Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser 
    290                 295                 300                 


Asn Thr Glu Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro 
305                 310                 315                 320 


Pro Arg Asn Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe 
                325                 330                 335     


Gln Arg Asp Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu 
            340                 345                 350         


Pro Arg Asn Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu 
        355                 360                 365             


Val Trp Ala Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr 
    370                 375                 380                 


Asp Arg Thr Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp 
385                 390                 395                 400 


Gly Ala Phe Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys 
                405                 410                 415     


Gly Pro Ser Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser 
            420                 425                 430         


Val Asp Tyr Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser 
        435                 440                 445             


Ile Pro Asp Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu 
    450                 455                 460                 


Ala Phe Ser Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp 
465                 470                 475                 480 


Tyr Gln Asn Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly 
                485                 490                 495     


Glu Val Glu Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro 
            500                 505                 510         


Ala Gly Pro Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn 
        515                 520                 525             


Ser Gly Pro Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu 
    530                 535                 540                 


Glu Ser Ser Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp 
545                 550                 555                 560 


Glu Cys Phe Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu 
                565                 570                 575     


Val Glu Ala Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile 
            580                 585                 590         


Asp Tyr Gly Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile 
        595                 600                 605             


Gln Thr Glu Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu 
    610                 615                 620                 


Phe Arg Arg Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr 
625                 630                 635                 640 


Gln Gln Phe Tyr Gln Pro Pro Arg Ala Arg Asn 
                645                 650     


<210>  6
<211>  744
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Gln Val Ala Gly Ala Ala Leu Ser Gln Ala Gly Trp Tyr Leu 
1               5                   10                  15      


Ser Asp Glu Gly Ile Glu Ala Cys Thr Ser Ser Pro Asp Lys Val Asn 
            20                  25                  30          


Val Asn Asp Ile Ile Leu Ile Ala Leu Asn Thr Asp Leu Arg Thr Ile 
        35                  40                  45              


Gly Lys Lys Phe Leu Pro Ser Asp Ile Asn Ser Gly Lys Val Glu Lys 
    50                  55                  60                  


Leu Glu Gly Pro Cys Val Leu Gln Ile Gln Lys Ile Arg Asn Val Ala 
65                  70                  75                  80  


Ala Pro Lys Asp Asn Glu Glu Ser Gln Ala Ala Pro Arg Met Leu Arg 
                85                  90                  95      


Leu Gln Met Thr Asp Gly His Ile Ser Cys Thr Ala Val Glu Phe Ser 
            100                 105                 110         


Tyr Met Ser Lys Ile Ser Leu Asn Thr Pro Pro Gly Thr Lys Val Lys 
        115                 120                 125             


Leu Ser Gly Ile Val Asp Ile Lys Asn Gly Phe Leu Leu Leu Asn Asp 
    130                 135                 140                 


Ser Asn Thr Thr Val Leu Gly Gly Glu Val Glu His Leu Ile Glu Lys 
145                 150                 155                 160 


Trp Glu Leu Gln Arg Ser Leu Ser Lys His Asn Arg Ser Asn Ile Gly 
                165                 170                 175     


Thr Glu Gly Gly Pro Pro Pro Phe Val Pro Phe Gly Gln Lys Cys Val 
            180                 185                 190         


Ser His Val Gln Val Asp Ser Arg Glu Leu Asp Arg Arg Lys Thr Leu 
        195                 200                 205             


Gln Val Thr Met Pro Val Lys Pro Thr Asn Asp Asn Asp Glu Phe Glu 
    210                 215                 220                 


Lys Gln Arg Thr Ala Ala Ile Ala Glu Val Ala Lys Ser Lys Glu Thr 
225                 230                 235                 240 


Lys Thr Phe Gly Gly Gly Gly Gly Gly Ala Arg Ser Asn Leu Asn Met 
                245                 250                 255     


Asn Ala Ala Gly Asn Arg Asn Arg Glu Val Leu Gln Lys Glu Lys Ser 
            260                 265                 270         


Thr Lys Ser Glu Gly Lys His Glu Gly Val Tyr Arg Glu Leu Val Asp 
        275                 280                 285             


Glu Lys Ala Leu Lys His Ile Thr Glu Met Gly Phe Ser Lys Glu Ala 
    290                 295                 300                 


Ser Arg Gln Ala Leu Met Asp Asn Gly Asn Asn Leu Glu Ala Ala Leu 
305                 310                 315                 320 


Asn Val Leu Leu Thr Ser Asn Lys Gln Lys Pro Val Met Gly Pro Pro 
                325                 330                 335     


Leu Arg Gly Arg Gly Lys Gly Arg Gly Arg Ile Arg Ser Glu Asp Glu 
            340                 345                 350         


Glu Asp Leu Gly Asn Ala Arg Pro Ser Ala Pro Ser Thr Leu Phe Asp 
        355                 360                 365             


Phe Leu Glu Ser Lys Met Gly Thr Leu Asn Val Glu Glu Pro Lys Ser 
    370                 375                 380                 


Gln Pro Gln Gln Leu His Gln Gly Gln Tyr Arg Ser Ser Asn Thr Glu 
385                 390                 395                 400 


Gln Asn Gly Val Lys Asp Asn Asn His Leu Arg His Pro Pro Arg Asn 
                405                 410                 415     


Asp Thr Arg Gln Pro Arg Asn Glu Lys Pro Pro Arg Phe Gln Arg Asp 
            420                 425                 430         


Ser Gln Asn Ser Lys Ser Val Leu Glu Gly Ser Gly Leu Pro Arg Asn 
        435                 440                 445             


Arg Gly Ser Glu Arg Pro Ser Thr Ser Ser Val Ser Glu Val Trp Ala 
    450                 455                 460                 


Glu Asp Arg Ile Lys Cys Asp Arg Pro Tyr Ser Arg Tyr Asp Arg Thr 
465                 470                 475                 480 


Lys Asp Thr Ser Tyr Pro Leu Gly Ser Gln His Ser Asp Gly Ala Phe 
                485                 490                 495     


Lys Lys Arg Asp Asn Ser Met Gln Ser Arg Ser Gly Lys Gly Pro Ser 
            500                 505                 510         


Phe Ala Glu Ala Lys Glu Asn Pro Leu Pro Gln Gly Ser Val Asp Tyr 
        515                 520                 525             


Asn Asn Gln Lys Arg Gly Lys Arg Glu Ser Gln Thr Ser Ile Pro Asp 
    530                 535                 540                 


Tyr Phe Tyr Asp Arg Lys Ser Gln Thr Ile Asn Asn Glu Ala Phe Ser 
545                 550                 555                 560 


Gly Ile Lys Ile Glu Lys His Phe Asn Val Asn Thr Asp Tyr Gln Asn 
                565                 570                 575     


Pro Val Arg Ser Asn Ser Phe Ile Gly Val Pro Asn Gly Glu Val Glu 
            580                 585                 590         


Met Pro Leu Lys Gly Arg Arg Ile Gly Pro Ile Lys Pro Ala Gly Pro 
        595                 600                 605             


Val Thr Ala Val Pro Cys Asp Asp Lys Ile Phe Tyr Asn Ser Gly Pro 
    610                 615                 620                 


Lys Arg Arg Ser Gly Pro Ile Lys Pro Glu Lys Ile Leu Glu Ser Ser 
625                 630                 635                 640 


Ile Pro Met Glu Tyr Ala Lys Met Trp Lys Pro Gly Asp Glu Cys Phe 
                645                 650                 655     


Ala Leu Tyr Trp Glu Asp Asn Lys Phe Tyr Arg Ala Glu Val Glu Ala 
            660                 665                 670         


Leu His Ser Ser Gly Met Thr Ala Val Val Lys Phe Ile Asp Tyr Gly 
        675                 680                 685             


Asn Tyr Glu Glu Val Leu Leu Ser Asn Ile Lys Pro Ile Gln Thr Glu 
    690                 695                 700                 


Ala Trp Glu Glu Glu Gly Thr Tyr Asp Gln Thr Leu Glu Phe Arg Arg 
705                 710                 715                 720 


Gly Gly Asp Gly Gln Pro Arg Arg Ser Thr Arg Pro Thr Gln Gln Phe 
                725                 730                 735     


Tyr Gln Pro Pro Arg Ala Arg Asn 
            740                 


<210>  7
<211>  2235
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcccagg tggccggcgc ggcgttgtcc caggcgggtt ggtatctttc agatgaaggc       60

attgaagctt gcacaagctc tccagacaaa gtcaatgtaa atgacatcat cctgattgct      120

ctcaatacag atctgagaac aattggcaag aaattcctcc ccagtgacat caatagtgga      180

aaggtagaaa agctcgaagg tccatgtgtt ttgcaaattc aaaaaattcg caatgttgct      240

gcaccaaagg ataatgaaga atctcaggct gcaccaagga tgctgcgatt acagatgact      300

gatggtcata taagttgcac agcagtagaa tttagttata tgtcaaaaat aagcctgaac      360

acaccacctg gaactaaagt taagctctca ggcattgttg acataaaaaa tggattcctg      420

ctcttgaatg actctaacac cacagttctt ggtggtgaag tggaacacct tattgagaaa      480

tgggagttac agagaagctt atcaaaacac aatagaagca atattggaac tgaaggtgga      540

ccaccgcctt ttgtgccttt tggacagaag tgtgtatctc atgtccaagt ggatagcaga      600

gaacttgatc gaagaaaaac attgcaagtt acaatgcctg tcaaacctac aaatgataat      660

gatgaatttg aaaagcaaag gacggctgct attgctgaag ttgcaaagag caaggaaacc      720

aagacatttg gaggaggtgg tggtggtgct agaagtaatc tcaatatgaa tgctgctggt      780

aaccgaaata gggaagtttt acagaaagaa aagtcaacca aatcagaggg aaaacatgaa      840

ggtgtctata gagaactggt tgatgagaaa gctctgaagc acataacgga aatgggcttc      900

agtaaggaag catcgaggca agctcttatg gataatggca acaacttaga agcagcactg      960

aacgtacttc ttacaagcaa taaacagaaa cctgttatgg gtcctcctct gagaggtaga     1020

ggaaaaggca gggggcgaat aagatctgaa gatgaagagg acctgggaaa tgcaaggcca     1080

tcagcaccaa gcacattatt tgatttcttg gaatctaaaa tgggaacttt gaatgtggaa     1140

gaacctaaat cacagccaca gcagcttcat cagggacaat acagatcatc aaatactgag     1200

caaaatggag taaaagataa taatcatctg agacatcctc ctcgaaatga taccaggcag     1260

ccaagaaatg aaaaaccgcc tcgttttcaa agagactccc aaaattcaaa gtcagtttta     1320

gaaggcagtg gattacctag aaatagaggt tctgaaagac caagtacttc ttcagtatct     1380

gaagtatggg ctgaagacag aatcaaatgt gatagaccgt attctagata tgacagaact     1440

aaagatactt catatccttt aggttctcag catagtgatg gtgcttttaa aaaaagagat     1500

aactctatgc aaagcagatc aggaaaaggt ccctcctttg cagaggcaaa agaaaatcca     1560

cttcctcaag gatctgtaga ttataataat caaaaacgtg gaaaaagaga aagccaaaca     1620

tctattcctg attattttta tgacaggaaa tcacaaacaa taaataatga agctttcagt     1680

ggtataaaaa ttgaaaaaca ttttaatgta aatactgatt atcagaatcc agttcgaagt     1740

aatagtttca ttggtgttcc aaatggagaa gtagaaatgc cactgaaagg aagacgaata     1800

ggacctatta agccagcagg acctgtcaca gctgtaccct gtgatgataa aatattttac     1860

aatagtgggc ccaaacgaag atctgggcca attaagccag aaaaaatact agaatcatct     1920

attcctatgg agtatgcaaa aatgtggaaa cctggagatg aatgttttgc actttattgg     1980

gaagacaaca agttttaccg ggcagaagtt gaagccctcc attcttcggg tatgacagca     2040

gttgttaaat tcattgacta cggaaactat gaagaggtgc tactgagcaa tatcaagccc     2100

attcaaacag aggcatggga ggaagaaggc acctacgatc aaactctgga gttccgtagg     2160

ggaggtgatg gccagccaag acgatccact cggccaaccc aacagtttta ccaaccaccc     2220

cgggctcgga actaa                                                      2235


<210>  8
<211>  1956
<212>  DNA
<213>  Homo sapiens

<400>  8
atgctgcgat tacagatgac tgatggtcat ataagttgca cagcagtaga atttagttat       60

atgtcaaaaa taagcctgaa cacaccacct ggaactaaag ttaagctctc aggcattgtt      120

gacataaaaa atggattcct gctcttgaat gactctaaca ccacagttct tggtggtgaa      180

gtggaacacc ttattgagaa atgggagtta cagagaagct tatcaaaaca caatagaagc      240

aatattggaa ctgaaggtgg accaccgcct tttgtgcctt ttggacagaa gtgtgtatct      300

catgtccaag tggatagcag agaacttgat cgaagaaaaa cattgcaagt tacaatgcct      360

gtcaaaccta caaatgataa tgatgaattt gaaaagcaaa ggacggctgc tattgctgaa      420

gttgcaaaga gcaaggaaac caagacattt ggaggaggtg gtggtggtgc tagaagtaat      480

ctcaatatga atgctgctgg taaccgaaat agggaagttt tacagaaaga aaagtcaacc      540

aaatcagagg gaaaacatga aggtgtctat agagaactgg ttgatgagaa agctctgaag      600

cacataacgg aaatgggctt cagtaaggaa gcatcgaggc aagctcttat ggataatggc      660

aacaacttag aagcagcact gaacgtactt cttacaagca ataaacagaa acctgttatg      720

ggtcctcctc tgagaggtag aggaaaaggc agggggcgaa taagatctga agatgaagag      780

gacctgggaa atgcaaggcc atcagcacca agcacattat ttgatttctt ggaatctaaa      840

atgggaactt tgaatgtgga agaacctaaa tcacagccac agcagcttca tcagggacaa      900

tacagatcat caaatactga gcaaaatgga gtaaaagata ataatcatct gagacatcct      960

cctcgaaatg ataccaggca gccaagaaat gaaaaaccgc ctcgttttca aagagactcc     1020

caaaattcaa agtcagtttt agaaggcagt ggattaccta gaaatagagg ttctgaaaga     1080

ccaagtactt cttcagtatc tgaagtatgg gctgaagaca gaatcaaatg tgatagaccg     1140

tattctagat atgacagaac taaagatact tcatatcctt taggttctca gcatagtgat     1200

ggtgctttta aaaaaagaga taactctatg caaagcagat caggaaaagg tccctccttt     1260

gcagaggcaa aagaaaatcc acttcctcaa ggatctgtag attataataa tcaaaaacgt     1320

ggaaaaagag aaagccaaac atctattcct gattattttt atgacaggaa atcacaaaca     1380

ataaataatg aagctttcag tggtataaaa attgaaaaac attttaatgt aaatactgat     1440

tatcagaatc cagttcgaag taatagtttc attggtgttc caaatggaga agtagaaatg     1500

ccactgaaag gaagacgaat aggacctatt aagccagcag gacctgtcac agctgtaccc     1560

tgtgatgata aaatatttta caatagtggg cccaaacgaa gatctgggcc aattaagcca     1620

gaaaaaatac tagaatcatc tattcctatg gagtatgcaa aaatgtggaa acctggagat     1680

gaatgttttg cactttattg ggaagacaac aagttttacc gggcagaagt tgaagccctc     1740

cattcttcgg gtatgacagc agttgttaaa ttcattgact acggaaacta tgaagaggtg     1800

ctactgagca atatcaagcc cattcaaaca gaggcatggg aggaagaagg cacctacgat     1860

caaactctgg agttccgtag gggaggtgat ggccagccaa gacgatccac tcggccaacc     1920

caacagtttt accaaccacc ccgggctcgg aactaa                               1956


<210>  9
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
1               5                   10                  15      


Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
            20                  25                  30          


Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
        35                  40                  45              


Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
    50                  55                  60                  


Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu 
65                  70                  75                  80  


Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu 
                85                  90                  95      


Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys 
            100                 105                 110         


Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn 
        115                 120                 125             


Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro 
    130                 135                 140                 


Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
145                 150                 155                 160 


Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp 
                165                 170                 175     


Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
            180                 185                 190         


Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
        195                 200                 205 


<210>  10
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
1               5                   10                  15      


Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
            20                  25                  30          


Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
        35                  40                  45              


Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
    50                  55                  60                  


Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Tyr 
65                  70                  75                  80  


Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu Glu Tyr Lys Lys 
                85                  90                  95      


Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys Lys Ile Tyr Asn 
            100                 105                 110         


Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn Leu Asp Ser Cys 
        115                 120                 125             


Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Leu Lys Ser Glu Pro 
    130                 135                 140                 


Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met 
145                 150                 155                 160 


Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Ser Tyr Leu Asp 
                165                 170                 175     


Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys 
            180                 185                 190         


Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
        195                 200                 205 


<210>  11
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Tyr Asn Met Met Leu Leu Ile Gln Lys Arg Lys Gly Ile Gly Ser 
1               5                   10                  15      


Gln Leu Leu Arg Ala Gly Glu Ala Glu Gly Asp Arg Gly Ala Gly Thr 
            20                  25                  30          


Ala Glu Arg Ser Ser Asp Trp Leu Asp Gly Arg Ser Trp Ala Ile Lys 
        35                  40                  45              


Glu Thr Pro Thr Gly Leu Ala Gly Arg Arg Ser Glu Asp Ser Asp Asn 
    50                  55                  60                  


Ile Phe Thr Gly Glu Glu Ala Lys Tyr Ala Gln Ser Arg Ser His Ser 
65                  70                  75                  80  


Ser Ser Cys Arg Ile Ser Phe Leu Leu Ala Asn Ser Lys Leu Leu Asn 
                85                  90                  95      


Lys Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser 
            100                 105                 110         


Ala Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp 
        115                 120                 125             


Ser Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile 
    130                 135                 140                 


Cys Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu 
145                 150                 155                 160 


Glu Asn Leu Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe 
                165                 170                 175     


Leu Lys Ser Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys 
            180                 185                 190         


Glu Glu Tyr Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala 
        195                 200                 205             


Lys Lys Ile Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val 
    210                 215                 220                 


Asn Leu Asp Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu 
225                 230                 235                 240 


Pro Thr Ile Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu 
                245                 250                 255     


Met Glu Lys Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu 
            260                 265                 270         


Asp Leu Val Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala 
        275                 280                 285             


Lys Ser Ser Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
    290                 295                 300         


<210>  12
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Cys Lys Gly Leu Ala Gly Leu Pro Ala Ser Cys Leu Arg Ser Ala 
1               5                   10                  15      


Lys Asp Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser 
            20                  25                  30          


Cys Glu His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys 
        35                  40                  45              


Gln Arg Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu 
    50                  55                  60                  


Asn Leu Ile Ser His Glu Cys Glu Pro Gly Phe Leu His Gln Gly Arg 
65                  70                  75                  80  


Asp Lys Pro Glu His Ala Arg Ala Tyr Asn Asn Leu Leu 
                85                  90              


<210>  13
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Lys His Arg Leu Gly Phe Leu Leu Gln Lys Ser Asp Ser Cys Glu 
1               5                   10                  15      


His Asn Ser Ser His Asn Lys Lys Asp Lys Val Val Ile Cys Gln Arg 
            20                  25                  30          


Val Ser Gln Glu Glu Val Lys Lys Trp Ala Glu Ser Leu Glu Asn Leu 
        35                  40                  45              


Ile Ser His Glu Cys Gly Leu Ala Ala Phe Lys Ala Phe Leu Lys Ser 
    50                  55                  60                  


Glu Tyr Ser Glu Glu Asn Ile Asp Phe Trp Ile Ser Cys Glu Glu Tyr 
65                  70                  75                  80  


Lys Lys Ile Lys Ser Pro Ser Lys Leu Ser Pro Lys Ala Lys Lys Ile 
                85                  90                  95      


Tyr Asn Glu Phe Ile Ser Val Gln Ala Thr Lys Glu Val Asn Leu Asp 
            100                 105                 110         


Ser Cys Thr Arg Glu Glu Thr Ser Arg Asn Met Leu Glu Pro Thr Ile 
        115                 120                 125             


Thr Cys Phe Asp Glu Ala Gln Lys Lys Ile Phe Asn Leu Met Glu Lys 
    130                 135                 140                 


Asp Ser Tyr Arg Arg Phe Leu Lys Ser Arg Phe Tyr Leu Asp Leu Val 
145                 150                 155                 160 


Asn Pro Ser Ser Cys Gly Ala Glu Lys Gln Lys Gly Ala Lys Ser Ser 
                165                 170                 175     


Ala Asp Cys Ala Ser Leu Val Pro Gln Cys Ala 
            180                 185         


<210>  14
<211>  909
<212>  DNA
<213>  Homo sapiens

<400>  14
atgtataata tgatgcttct aatccaaaag aggaaaggca ttgggagtca gctcctaagg       60

gctggagagg cagagggaga cagaggagct ggtactgcag agcggtcgtc tgattggctg      120

gacggtcgta gctgggctat aaaagagacc cctacaggct tagcaggaag acgctcagag      180

gattctgaca atatctttac cggagaagag gcaaagtacg ctcaaagccg aagccacagc      240

tcctcctgcc gcatttcttt cctgcttgcg aattccaagc tgttaaataa gatgtgcaaa      300

gggcttgcag gtctgccggc ttcttgcttg aggagtgcaa aagatatgaa acatcggcta      360

ggtttcctgc tgcaaaaatc tgattcctgt gaacacaatt cttcccacaa caagaaggac      420

aaagtggtta tttgccagag agtgagccaa gaggaagtca agaaatgggc tgaatcactg      480

gaaaacctga ttagtcatga atgtgggctg gcagctttca aagctttctt gaagtctgaa      540

tatagtgagg agaatattga cttctggatc agctgtgaag agtacaagaa aatcaaatca      600

ccatctaaac taagtcccaa ggccaaaaag atctataatg aattcatctc agtccaggca      660

accaaagagg tgaacctgga ttcttgcacc agggaagaga caagccggaa catgctagag      720

cctacaataa cctgctttga tgaggcccag aagaagattt tcaacctgat ggagaaggat      780

tcctaccgcc gcttcctcaa gtctcgattc tatcttgatt tggtcaaccc gtccagctgt      840

ggggcagaaa agcagaaagg agccaagagt tcagcagact gtgcttccct ggtccctcag      900

tgtgcctaa                                                              909


<210>  15
<211>  618
<212>  DNA
<213>  Homo sapiens

<400>  15
atgtgcaaag ggcttgcagg tctgccggct tcttgcttga ggagtgcaaa agatatgaaa       60

catcggctag gtttcctgct gcaaaaatct gattcctgtg aacacaattc ttcccacaac      120

aagaaggaca aagtggttat ttgccagaga gtgagccaag aggaagtcaa gaaatgggct      180

gaatcactgg aaaacctgat tagtcatgaa tgtgggctgg cagctttcaa agctttcttg      240

aagtctgaat atagtgagga gaatattgac ttctggatca gctgtgaaga gtacaagaaa      300

atcaaatcac catctaaact aagtcccaag gccaaaaaga tctataatga attcatctca      360

gtccaggcaa ccaaagaggt gaacctggat tcttgcacca gggaagagac aagccggaac      420

atgctagagc ctacaataac ctgctttgat gaggcccaga agaagatttt caacctgatg      480

gagaaggatt cctaccgccg cttcctcaag tctcgattct atcttgattt ggtcaacccg      540

tccagctgtg gggcagaaaa gcagaaagga gccaagagtt cagcagactg tgcttccctg      600

gtccctcagt gtgcctaa                                                    618


<210>  16
<211>  564
<212>  DNA
<213>  Homo sapiens

<400>  16
atgaaacatc ggctaggttt cctgctgcaa aaatctgatt cctgtgaaca caattcttcc       60

cacaacaaga aggacaaagt ggttatttgc cagagagtga gccaagagga agtcaagaaa      120

tgggctgaat cactggaaaa cctgattagt catgaatgtg ggctggcagc tttcaaagct      180

ttcttgaagt ctgaatatag tgaggagaat attgacttct ggatcagctg tgaagagtac      240

aagaaaatca aatcaccatc taaactaagt cccaaggcca aaaagatcta taatgaattc      300

atctcagtcc aggcaaccaa agaggtgaac ctggattctt gcaccaggga agagacaagc      360

cggaacatgc tagagcctac aataacctgc tttgatgagg cccagaagaa gattttcaac      420

ctgatggaga aggattccta ccgccgcttc ctcaagtctc gattctatct tgatttggtc      480

aacccgtcca gctgtggggc agaaaagcag aaaggagcca agagttcagc agactgtgct      540

tccctggtcc ctcagtgtgc ctaa                                             564


<210>  17
<211>  282
<212>  DNA
<213>  Homo sapiens

<400>  17
atgtgcaaag ggcttgcagg tctgccggct tcttgcttga ggagtgcaaa agatatgaaa       60

catcggctag gtttcctgct gcaaaaatct gattcctgtg aacacaattc ttcccacaac      120

aagaaggaca aagtggttat ttgccagaga gtgagccaag aggaagtcaa gaaatgggct      180

gaatcactgg aaaacctgat tagtcatgaa tgtgaacctg gattcttgca ccagggaaga      240

gacaagccgg aacatgctag agcctacaat aacctgcttt ga                         282


<210>  18
<211>  1108
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Ser Lys Gly Val Tyr Gln Tyr His Trp Gln Ser His Asn Val 
1               5                   10                  15      


Lys His Ser Gly Val Asp Asp Met Val Leu Leu Ser Lys Ile Thr Glu 
            20                  25                  30          


Asn Ser Ile Val Glu Asn Leu Lys Lys Arg Tyr Met Asp Asp Tyr Ile 
        35                  40                  45              


Phe Thr Tyr Ile Gly Ser Val Leu Ile Ser Val Asn Pro Phe Lys Gln 
    50                  55                  60                  


Met Pro Tyr Phe Gly Glu Lys Glu Ile Glu Met Tyr Gln Gly Ala Ala 
65                  70                  75                  80  


Gln Tyr Glu Asn Pro Pro His Ile Tyr Ala Leu Ala Asp Asn Met Tyr 
                85                  90                  95      


Arg Asn Met Ile Ile Asp Arg Glu Asn Gln Cys Val Ile Ile Ser Gly 
            100                 105                 110         


Glu Ser Gly Ala Gly Lys Thr Val Ala Ala Lys Tyr Ile Met Ser Tyr 
        115                 120                 125             


Ile Ser Arg Val Ser Gly Gly Gly Thr Lys Val Gln His Val Lys Asp 
    130                 135                 140                 


Ile Ile Leu Gln Ser Asn Pro Leu Leu Glu Ala Phe Gly Asn Ala Lys 
145                 150                 155                 160 


Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys Tyr Phe Glu Ile 
                165                 170                 175     


Gln Phe Ser Pro Gly Gly Glu Pro Asp Gly Gly Lys Ile Ser Asn Phe 
            180                 185                 190         


Leu Leu Glu Lys Ser Arg Val Val Met Arg Asn Pro Gly Glu Arg Ser 
        195                 200                 205             


Phe His Ile Phe Tyr Gln Leu Ile Glu Gly Ala Ser Ala Glu Gln Lys 
    210                 215                 220                 


His Ser Leu Gly Ile Thr Ser Met Asp Tyr Tyr Tyr Tyr Leu Ser Leu 
225                 230                 235                 240 


Ser Gly Ser Tyr Lys Val Asp Asp Ile Asp Asp Arg Arg Glu Phe Gln 
                245                 250                 255     


Glu Thr Leu His Ala Met Asn Val Ile Gly Ile Phe Ala Glu Glu Gln 
            260                 265                 270         


Thr Leu Val Leu Gln Ile Val Ala Gly Ile Leu His Leu Gly Asn Ile 
        275                 280                 285             


Ser Phe Lys Glu Val Gly Asn Tyr Ala Ala Val Glu Ser Glu Glu Phe 
    290                 295                 300                 


Leu Ala Phe Pro Ala Tyr Leu Leu Gly Ile Asn Gln Asp Arg Leu Lys 
305                 310                 315                 320 


Glu Lys Leu Thr Ser Arg Gln Met Asp Ser Lys Trp Gly Gly Lys Ser 
                325                 330                 335     


Glu Ser Ile His Val Thr Leu Asn Val Glu Gln Ala Cys Tyr Thr Arg 
            340                 345                 350         


Asp Ala Leu Ala Lys Ala Leu His Ala Arg Val Phe Asp Phe Leu Val 
        355                 360                 365             


Asp Ser Ile Asn Lys Ala Met Glu Lys Asp His Glu Glu Tyr Asn Ile 
    370                 375                 380                 


Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Gln Lys Asn Gly Phe 
385                 390                 395                 400 


Glu Gln Phe Cys Ile Asn Phe Val Asn Glu Lys Leu Gln Gln Ile Phe 
                405                 410                 415     


Ile Glu Leu Thr Leu Lys Ala Glu Gln Glu Glu Tyr Val Gln Glu Gly 
            420                 425                 430         


Ile Arg Trp Thr Pro Ile Glu Tyr Phe Asn Asn Lys Ile Val Cys Asp 
        435                 440                 445             


Leu Ile Glu Asn Lys Val Asn Pro Pro Gly Ile Met Ser Ile Leu Asp 
    450                 455                 460                 


Asp Val Cys Ala Thr Met His Ala Val Gly Glu Gly Ala Asp Gln Thr 
465                 470                 475                 480 


Leu Leu Gln Lys Leu Gln Met Gln Ile Gly Ser His Glu His Phe Asn 
                485                 490                 495     


Ser Trp Asn Gln Gly Phe Ile Ile His His Tyr Ala Gly Lys Val Ser 
            500                 505                 510         


Tyr Asp Met Asp Gly Phe Cys Glu Arg Asn Arg Asp Val Leu Phe Met 
        515                 520                 525             


Asp Leu Ile Glu Leu Met Gln Ser Ser Glu Leu Pro Phe Ile Lys Ser 
    530                 535                 540                 


Leu Phe Pro Glu Asn Leu Gln Ala Asp Lys Lys Gly Arg Pro Thr Thr 
545                 550                 555                 560 


Ala Gly Ser Lys Ile Lys Lys Gln Ala Asn Asp Leu Val Ser Thr Leu 
                565                 570                 575     


Met Lys Cys Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn Glu Thr 
            580                 585                 590         


Lys Lys Pro Arg Asp Trp Glu Glu Ser Arg Val Lys His Gln Val Glu 
        595                 600                 605             


Tyr Leu Gly Leu Lys Glu Asn Ile Arg Val Arg Arg Ala Gly Tyr Ala 
    610                 615                 620                 


Tyr Arg Arg Ile Phe Gln Lys Phe Leu Gln Arg Tyr Ala Ile Leu Thr 
625                 630                 635                 640 


Lys Ala Thr Trp Pro Ser Trp Gln Gly Glu Glu Lys Gln Gly Val Leu 
                645                 650                 655     


His Leu Leu Gln Ser Val Asn Met Asp Ser Asp Gln Phe Gln Leu Gly 
            660                 665                 670         


Arg Ser Lys Val Phe Ile Lys Ala Pro Glu Ser Leu Phe Leu Leu Glu 
        675                 680                 685             


Glu Met Arg Glu Arg Lys Tyr Asp Gly Tyr Ala Arg Val Ile Gln Lys 
    690                 695                 700                 


Ser Trp Arg Lys Phe Val Ala Arg Lys Lys Tyr Val Gln Met Arg Glu 
705                 710                 715                 720 


Glu Ala Ser Asp Leu Leu Leu Asn Lys Lys Glu Arg Arg Arg Asn Ser 
                725                 730                 735     


Ile Asn Arg Asn Phe Ile Gly Asp Tyr Ile Gly Met Glu Glu His Pro 
            740                 745                 750         


Glu Leu Gln Gln Phe Val Gly Lys Arg Glu Lys Ile Asp Phe Ala Asp 
        755                 760                 765             


Thr Val Thr Lys Tyr Asp Arg Arg Phe Lys Gly Val Lys Arg Asp Leu 
    770                 775                 780                 


Leu Leu Thr Pro Lys Cys Leu Tyr Leu Ile Gly Arg Glu Lys Val Lys 
785                 790                 795                 800 


Gln Gly Pro Asp Lys Gly Leu Val Lys Glu Val Leu Lys Arg Lys Ile 
                805                 810                 815     


Glu Ile Glu Arg Ile Leu Ser Val Ser Leu Ser Thr Met Gln Asp Asp 
            820                 825                 830         


Ile Phe Ile Leu His Glu Gln Glu Tyr Asp Ser Leu Leu Glu Ser Val 
        835                 840                 845             


Phe Lys Thr Glu Phe Leu Ser Leu Leu Ala Lys Arg Tyr Glu Glu Lys 
    850                 855                 860                 


Thr Gln Lys Gln Leu Pro Leu Lys Phe Ser Asn Thr Leu Glu Leu Lys 
865                 870                 875                 880 


Leu Lys Lys Glu Asn Trp Gly Pro Trp Ser Ala Gly Gly Ser Arg Gln 
                885                 890                 895     


Val Gln Phe His Gln Gly Phe Gly Asp Leu Ala Val Leu Lys Pro Ser 
            900                 905                 910         


Asn Lys Val Leu Gln Val Ser Ile Gly Pro Gly Leu Pro Lys Asn Ser 
        915                 920                 925             


Arg Pro Thr Arg Arg Asn Thr Thr Gln Asn Thr Gly Tyr Ser Ser Gly 
    930                 935                 940                 


Thr Gln Asn Ala Asn Tyr Pro Val Arg Ala Ala Pro Pro Pro Pro Gly 
945                 950                 955                 960 


Tyr His Gln Asn Gly Val Ile Arg Asn Gln Tyr Val Pro Tyr Pro His 
                965                 970                 975     


Ala Pro Gly Ser Gln Arg Ser Asn Gln Lys Ser Leu Tyr Thr Ser Met 
            980                 985                 990         


Ala Arg Pro Pro Leu Pro Arg Gln  Gln Ser Thr Ser Ser  Asp Arg Val 
        995                 1000                 1005             


Ser Gln  Thr Pro Glu Ser Leu  Asp Phe Leu Lys Val  Pro Asp Gln 
    1010                 1015                 1020             


Gly Ala  Ala Gly Val Arg Arg  Gln Thr Thr Ser Arg  Pro Pro Pro 
    1025                 1030                 1035             


Ala Gly  Gly Arg Pro Lys Pro  Gln Pro Lys Pro Lys  Pro Gln Val 
    1040                 1045                 1050             


Pro Gln  Cys Lys Ala Leu Tyr  Ala Tyr Asp Ala Gln  Asp Thr Asp 
    1055                 1060                 1065             


Glu Leu  Ser Phe Asn Ala Asn  Asp Ile Ile Asp Ile  Ile Lys Glu 
    1070                 1075                 1080             


Asp Pro  Ser Gly Trp Trp Thr  Gly Arg Leu Arg Gly  Lys Gln Gly 
    1085                 1090                 1095             


Leu Phe  Pro Asn Asn Tyr Val  Thr Lys Ile 
    1100                 1105             


<210>  19
<211>  3327
<212>  DNA
<213>  Homo sapiens

<400>  19
atgggaagca aaggtgtcta ccagtaccac tggcaaagcc acaatgtcaa gcacagtggt       60

gtggacgaca tggtgctact gtccaagatc acagagaact ccatcgtgga gaatctgaag      120

aagagataca tggatgacta catttttaca tatataggat ctgtattaat ctcagtcaac      180

cctttcaagc agatgccata ttttggggaa aaggaaattg aaatgtacca aggagcggca      240

cagtatgaaa acccaccaca tatctatgcc cttgcagata atatgtacag aaacatgatc      300

attgacagag agaaccagtg cgtcattatc agtggtgaaa gtggtgctgg aaaaacagtg      360

gctgccaaat atatcatgag ctacatctcc agagtgtctg gaggagggac caaagtccag      420

cacgtgaagg acattatcct gcagtccaac ccgctgctgg aggccttcgg gaacgccaag      480

accgtccgga acaacaactc cagccgattt ggaaaatact ttgaaatcca gttcagtcca      540

ggtggggaac cagatggtgg aaagatctcc aacttccttc tggaaaaatc tagggtggtg      600

atgaggaacc caggagagcg gagttttcac atattttacc agctcatcga gggcgcctct      660

gcagagcaga aacacagcct tggcatcacc agcatggact attattacta cctgagcctc      720

tcgggctcat acaaggttga tgacattgac gacaggcggg agtttcagga aactctgcac      780

gccatgaatg tgattgggat ctttgcagaa gagcaaacgc tggtgttgca gatagtggcg      840

ggtattctcc acctgggaaa catcagcttc aaagaagttg gcaactacgc ggctgtggag      900

agtgaagagt ttttagcttt tcctgcatat ctgctaggga taaaccagga ccggttgaaa      960

gaaaagctaa caagccggca gatggatagc aagtggggag gcaaatccga atccatccac     1020

gtgaccctca acgtagagca ggcctgttac acccgggatg cgctcgccaa ggccctgcac     1080

gcccgggtct ttgatttctt ggtagattcc atcaataaag ccatggagaa agaccatgaa     1140

gaatacaaca ttggcgtcct agacatctat ggctttgaaa tattccagaa aaatggcttt     1200

gaacagtttt gtatcaattt tgttaatgaa aaactgcagc agatttttat tgaactgaca     1260

ttaaaggcag aacaggaaga atatgttcaa gagggaataa gatggacacc cattgagtac     1320

tttaataata aaatcgtatg tgacctcata gagaacaaag tgaaccctcc tggcatcatg     1380

agcatcctgg atgacgtgtg cgccacgatg catgcggtgg gtgagggggc agatcagacg     1440

ctgctccaga aacttcagat gcagattggg agtcatgagc acttcaacag ttggaaccaa     1500

ggcttcatca ttcatcatta tgctgggaag gtatcctatg acatggatgg cttttgtgaa     1560

aggaaccggg atgtgctttt tatggatctc atcgagctta tgcagagcag cgagctgcct     1620

ttcataaagt ctttatttcc ggaaaatctg caggctgaca agaaagggcg cccaactact     1680

gccggaagca aaataaagaa acaagccaat gaccttgtga gcaccctgat gaaatgtacg     1740

ccccactaca ttcgctgcat caagccaaac gaaaccaaga agcccagaga ctgggaggaa     1800

agcagggtaa agcatcaagt cgaatatttg ggtctgaaag agaacattcg agtgagaaga     1860

gctggctatg cctatcggcg catcttccaa aaattcctac agaggtatgc cattctgacc     1920

aaagccacct ggccttcttg gcagggagag gagaagcaag gcgtcctgca cctgctgcag     1980

tcggtcaaca tggacagcga ccagttccag ctggggagga gtaaagtgtt catcaaagcc     2040

cccgagtctc tatttctttt agaagagatg agagagagaa agtatgatgg gtatgctcga     2100

gtgatacaga aatcatggag gaaattcgtg gcccggaaga aatacgttca aatgagagaa     2160

gaagcctcag acctcttatt gaacaagaag gagagaagga gaaacagtat taacaggaac     2220

tttatagggg attatattgg gatggaagag cacccagaac tccagcagtt cgtgggcaag     2280

agggagaaga ttgatttcgc agacacagtc accaagtatg acaggaggtt caagggtgta     2340

aagcgagacc tgctccttac cccaaagtgc ttgtacttaa tcggacgaga aaaagtcaaa     2400

cagggcccag acaagggcct ggtgaaagaa gtcctgaagc ggaaaatcga gatagaacgg     2460

atcttgtctg tgtccctcag tactatgcag gatgacattt ttattctcca tgagcaagag     2520

tatgacagtt tgcttgaatc tgtcttcaaa actgaattcc taagcctctt agcaaagcgt     2580

tacgaggaga agacccagaa gcaactacct ctgaaattca gcaatacgct tgaactgaag     2640

ttgaaaaagg aaaactgggg cccctggagt gcagggggct cccggcaagt gcagttccac     2700

caagggtttg gggacctggc tgtcctcaag cccagtaaca aagtgctgca ggtcagcatc     2760

ggacctggac tgcccaagaa ctcccgtcct accagaagga acactaccca aaatacaggt     2820

tattccagtg ggactcaaaa tgccaactac ccagtgagag ctgcccctcc tcccccagga     2880

taccatcaga acggagtcat cagaaaccag tatgtgccat atccccatgc tcctggaagc     2940

cagaggtcca atcagaaaag cctgtacacc tccatggccc gcccgccctt gcctcggcag     3000

cagtctacca gttcagaccg agtgtcacag acgccagaga gcctggattt cctcaaggtc     3060

ccggaccagg gagctgcagg ggtcaggaga caaacaacca gtcggcctcc cccagcaggg     3120

ggcagaccca agccccagcc caagcccaag cctcaggtgc cacagtgcaa ggctttgtat     3180

gcctatgacg ctcaggacac agacgaactc agctttaatg ccaatgacat tattgatatt     3240

atcaaagaag atccttctgg ctggtggacg ggtcgactac gaggcaagca gggcctgttc     3300

cccaacaact atgtgaccaa gatctga                                         3327


<210>  20
<211>  432
<212>  DNA
<213>  Homo sapiens

<400>  20
atggtgccag actggagtcc ttttattaaa attaactgcc ctgctcagct ttctgctggg       60

ccaccccaga gccaatcctt ggttcttggg cccaaggctg gacccagggg ttgcaggaaa      120

cagtctgtag catccaagtg gggcctgtcg tacccactcc agtgtgtagg tgcagaacgc      180

tctttggggg atttctctgc tgggccacct tactccaggg atccctcagt tttcaaaaca      240

aagcaagagg gcaaggaaga atggagaaac agctcagtgt tgactctctt ccccctggtg      300

agtgctgtgc tggggcctct gtgcacatca taccacttcc cccttgaatc agccccacaa      360

ggcagggtga gagatgagga ctcagggtgc aaggaggtct cacagcttgg aaatggatca      420

ggacagctct ga                                                          432


<210>  21
<211>  5243
<212>  DNA
<213>  Homo sapiens

<400>  21
gcagttaagt atttgtttaa tcttgctttg tcttttcaaa cagcgattta gtaatcctgt       60

ttgaggctgc agtgtggcaa tgctttccag aggatggagt cctttttgtt tgttttgaaa      120

aaatagagat ggggtttcac tatgttgcct aggctggtct catactcggc ctcgagccat      180

cctcctgcct gggcctccca aagtgttggg attacaggcg tgagccatgg tgccagactg      240

gagtcctttt attaaaatta actgccctgc tcagctttct gctgggccac cccagagcca      300

atccttggtt cttgggccca aggctggacc caggggttgc aggaaacagt ctgtagcatc      360

caagtggggc ctgtcgtacc cactccagtg tgtaggtgca gaacgctctt tgggggattt      420

ctctgctggg ccaccttact ccagggatcc ctcagttttc aaaacaaagc aagagggcaa      480

ggaagaatgg agaaacagct cagtgttgac tctcttcccc ctggtgagtg ctgtgctggg      540

gcctctgtgc acatcatacc acttccccct tgaatcagcc ccacaaggca gggtgagaga      600

tgaggactca gggtgcaagg aggtctcaca gcttggaaat ggatcaggac agctctgatt      660

ctccaaggcc aaggtcttct ctatatcatg aggcagccca aaaatgtgtt tctacacata      720

ttctgtgtag aaactcaggc caggctccta tatgctctgg gtgacagcgg gaaggtgctt      780

tccagtgtgt atcagtgtgg cccatctggg agtcataatg tcattgcctc ttccaaaata      840

tcagcaaagc tgaccctagt gcttgtagtg ctcaaatgca cctctctgcc tttgtgccat      900

agggaaatgg atttggtcct gggggtggtg ataccaactt ctgtctcaat tccatgaccc      960

tcactcagca cccccacccc aggcctgtgc agaggaggaa taaccgtcct tgagaaccat     1020

ccagccctag gtggagaaat tagatttatg gacttaatca gttcttcttc cctgtcagtg     1080

gtggtgagaa tgacatgggg gaaattgata agcctcagtc atgttttcct gcgagacaag     1140

gcagctttgg tagctggtgg gactgacgcc ttcttcacct gtgtcctctg cctctgagtg     1200

actataaatt gcgaacccca tgaggtggca cctgcagcca cagatcgctt aggcaccttg     1260

cacagggggc cacctaatga actggctgca ggacggcaat cctgccgtga agccaggcac     1320

ctcgggaggg gcaaggtggc agaaccgaga gagcagatgc tccttgctgt ttctgtaagg     1380

ccaccagtgg ctgggtggcc tggccctggt agcaaggtgg taaccgtgtg agtggctgaa     1440

tcctgcacca cttttcctga gcctccttcc tcctggattc ctgcaactat attctcacta     1500

catggctcac caccaattcg ttctctctgc cccaaggagg ctggacaaga ggctcaggtc     1560

agtgcgggta cgcaggaacc tatgtctgta aaatgaaaat gcctgccttc aagggctgtc     1620

ttgaggttga aaggagatgg tctacatcaa gggttaggaa gaccacaatg tggctgtgcc     1680

ggccacctcc aggctggctt cagtctccca tccccatagt catacccctg tgaagtccct     1740

tcccatactg aatcgggcta cctgtgtatc ttatagggtg ttggaaatga cagattgtga     1800

attccaaggc cccataaaag acagcgtggg ctgggcgtgg tggctcacgc ctgtaatccc     1860

agcactttgg gaggccgagc caagtggatc acttgaggtc aggagttcta gaccagcctg     1920

gccagcatgg tgaaaaccta tctctactaa aaatacaaaa aaaaaaattt agccaggtgt     1980

gttggcacct gtgcctgtag tcccagatac ttgggaggct gagccaggag aatcacttga     2040

acctgagagg tggaggtttc agtgagccga gattgtgcca ctgcactcca gctgggtggc     2100

agagactctg tctctaaaca aagaaaatgt ggtttctgct gtcctttctc ttggatcact     2160

ttctctggga aaccagccac catcttgtga ggacactcaa gctctctgga aaggttcaga     2220

aatgtggtga ggaagtgaga cagacctctt gccaaaaacc atgtactaac ttatcagtca     2280

cgtacatgag ttgacttaga aatgactcta tcagcctcag ccaaaccttc agatgactgc     2340

agccctggtc aacatcttga ctgtgacccc atggaagacc ctgaaacact cagccaagcc     2400

actctcagct tcctgatcca cagaagcagc atgaaataat aaatttttct tgttttaaac     2460

taagttttgg gttaatttgt tatacagctg tagataactc caagaataat actccataaa     2520

tgttgatttc ctttctgcgg ctccactgag tcatctttgt tcatgggcaa agctcactgt     2580

ctctctactg gctgcaaaag atgtccattt gttggctctg actcatgctt gtggtcttgt     2640

tggctcacag caaggccttt tcacagagga tggtggtttg tcacactcag aatccaggtc     2700

ttacctgctt tcctgctcca tggaattttg acctgagttt gaaggctgat aggggattga     2760

tggatgaggg agaaagacac agtcagttct tagagcagta gctaatccag gggtttctct     2820

ggctttgttt gcatgagtag tgatagttgg ggatgaagca tgggtattcg agatcttttt     2880

tgtgtgagta tgggaggaaa aattctgttc tcttcctcct ccatctttat tcatctttgt     2940

cttccctcgg atcagcttta aagacccctg agactctagg actcggtttg cttttttctc     3000

accactggga tccatctccc actagtagga agaaggatct aagtagttga gctgcataaa     3060

ggggaagtaa acagccagac aaatgttaca ttttagagcc ttgagtgacc cagagctttc     3120

tatcagcttc attgggtgca gggagggtag cgatttctgg ctgctgtcac ctccttgctc     3180

atatcaggaa gcgctaattt tgaggcaaag ttcagtgccc tctggctcac ctagggcccc     3240

tgttgcctaa tttcacgagg ccaagagttt gagggtgggt tcggggctgc gcagcctgga     3300

tgccttggtt tgcatgccta cagcagctgt gcccgaaagc tttttttaga gtaaatatgt     3360

agcttttgct aggctttttg tgtgccttgt tcattcctct atcatttttt gtatacctgc     3420

tatggtgtca ggcactgggg atacaaatta gccggggact cggacatgta agcaagtaag     3480

cccaacagca gctaacattt atgcagtgct cactgtgtgc ttggatgtcc agagtgatag     3540

agcaggttta gtaaggggga cagagggctg agaccagagg caaggtggag aagggcattt     3600

ctggaggcag caatatgagt gcaaaggaga catacacaag gttccctggg ggattccaag     3660

ttgttgctgt cgtggcttca aatcttactt tagggcctac tcagatggca tcttgttcat     3720

gaagatgtgc ctgttttttg ttttatttgt ccctctcccc ccaacaaaga gtaaactttt     3780

tttctgaact tctcgaaagt ttgctaacat cagctataaa actctctggg cctgggatat     3840

tttgcgggga gcagggaaga tctttgatta tcattttaac ttatttctgt tcatttattc     3900

aagctttttc ttctttcacc aattctcaaa agccccacac caccctcctg ccaaccccac     3960

acccctccac ttccagtcgc taccttccac ccatcattct cacttctaaa gccatcaaca     4020

gaggttttga acaccactca tgtgccaggt gttgttctaa gcacagattc atcagtgagc     4080

caaatgaaat tccttcctaa aatatgctct ttggtggtgc taaatgccag gaagaaaagt     4140

aagcaagggg agggaagaga gaggtgtggg gtggcggggg gcgggagctt ggataggatg     4200

gtcagaaagg acctctttgt agaaacttaa ataaatttag aaagcaagtc atgtaatatc     4260

tgggaaagag gaaatagcag gtgcaaagac cctgaggttg aagtgtcctg gcaagtttga     4320

ggcaagcaag gaaggcaggg tggttggaac agaacaagag aagaaacgtg gtaggaaatg     4380

atggagagtc agggacacga ccttggagga cttgcaggtc atggtaaaga cgctggactc     4440

gacacgaagt gtgaacagag ttcttggagg attctgaggt agagagtagc ataatctcat     4500

ttgtgttttt attctaacat gctcacttgg gccaccttgt agaggctaga gtgaaaagga     4560

gggagactag ttagaaattc tgtattgctg gctgggcgtg gtagctcccg gcactgtggg     4620

aggccaaggc cagaggattg cttgagtcta gcagtttgag cccagcctag gcaacatagc     4680

gagaccctgt ctctacaaaa aattttaaaa ttgcccaggg atggtggtgc acacttgtag     4740

tcccaactac ttgggaggct gaggtgggag gattgcctga gcccaggagt ttgaggctcc     4800

agtgagctgt gattgtgcca ttgcactcca gcctgggtga cagagcgaga ccctgtctct     4860

aaaaaaaaaa gaaaaaaaaa gaaattctgt attgcagcag cctaagagag tcattagtta     4920

agagatttgt agtaggcatt ttttagaaag ttgcattgag ggctaggtac ggtggctcat     4980

gcctataatc ccagcacttt gggaggccaa ggtgggtaga tcatttgagg tcaggagcct     5040

ggccaacata gcgaaacccc gtctctacta aaaaaattag ccgggcggta gtggcatgcg     5100

cctgtaatcc cagctactcg ggaggctgag gcaggagaat tgcttgagcc tgggaggtgg     5160

aggttgccag tgagtcgaga tcgcgccact gcactccagc agtctgggcg acagagtgag     5220

acgctgtttc aaaaaaaaaa aag                                             5243


<210>  22
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15      


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30          


Pro Lys Asp Asp Pro Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45              


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60                  


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80  


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95      


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110         


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125             


Ala Phe Thr Lys Tyr Cys Lys Lys Trp Gln Asp Glu Asp Gly Lys Lys 
    130                 135                 140                 


Gln Leu Glu Lys Asp Phe Ser Ser Met Lys Lys Tyr Cys Gln Val Ile 
145                 150                 155                 160 


Arg Val Ile Ala His Thr Gln Met Arg Leu Leu Pro Leu Arg Gln Lys 
                165                 170                 175     


Lys Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu 
            180                 185                 190         


Lys Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn 
        195                 200                 205             


Gln Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys 
    210                 215                 220                 


Gly Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu 
225                 230                 235                 240 


Pro Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala 
                245                 250                 255     


Trp His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys 
            260                 265                 270         


Gly Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly 
        275                 280                 285             


Gln Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser 
    290                 295                 300                 


Thr Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe 
305                 310                 315                 320 


Val His Tyr Gly Glu Val Thr Asn Asp Phe Val Met Leu Lys Gly Cys 
                325                 330                 335     


Val Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu 
            340                 345                 350         


Val Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile 
        355                 360                 365             


Asp Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu 
    370                 375                 380                 


Lys Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Ala 
            


<210>  23
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ser His Arg Lys Phe Ser Ala Pro Arg His Gly Ser Leu Gly Phe 
1               5                   10                  15      


Leu Pro Arg Lys Arg Ser Ser Arg His Arg Gly Lys Val Lys Ser Phe 
            20                  25                  30          


Pro Lys Asp Asp Ala Ser Lys Pro Val His Leu Thr Ala Phe Leu Gly 
        35                  40                  45              


Tyr Lys Ala Gly Met Thr His Ile Val Arg Glu Val Asp Arg Pro Gly 
    50                  55                  60                  


Ser Lys Val Asn Lys Lys Glu Val Val Glu Ala Val Thr Ile Val Glu 
65                  70                  75                  80  


Thr Pro Pro Met Val Val Val Gly Ile Val Gly Tyr Val Glu Thr Pro 
                85                  90                  95      


Arg Gly Leu Arg Thr Phe Lys Thr Val Phe Ala Glu His Ile Ser Asp 
            100                 105                 110         


Glu Cys Lys Arg Arg Phe Tyr Lys Asn Trp His Lys Ser Lys Lys Lys 
        115                 120                 125             


Ala Phe Thr Lys Tyr Cys Lys Lys Trp Gln Asp Asp Thr Gly Lys Lys 
    130                 135                 140                 


Gln Leu Glu Lys Asp Phe Asn Ser Met Lys Lys Tyr Cys Gln Val Ile 
145                 150                 155                 160 


Arg Ile Ile Ala His Thr Gln Met Arg Leu Leu Pro Leu Arg Gln Lys 
                165                 170                 175     


Lys Ala His Leu Met Glu Ile Gln Val Asn Gly Gly Thr Val Ala Glu 
            180                 185                 190         


Lys Leu Asp Trp Ala Arg Glu Arg Leu Glu Gln Gln Val Pro Val Asn 
        195                 200                 205             


Gln Val Phe Gly Gln Asp Glu Met Ile Asp Val Ile Gly Val Thr Lys 
    210                 215                 220                 


Gly Lys Gly Tyr Lys Gly Val Thr Ser Arg Trp His Thr Lys Lys Leu 
225                 230                 235                 240 


Pro Arg Lys Thr His Arg Gly Leu Arg Lys Val Ala Cys Ile Gly Ala 
                245                 250                 255     


Trp His Pro Ala Arg Val Ala Phe Ser Val Ala Arg Ala Gly Gln Lys 
            260                 265                 270         


Gly Tyr His His Arg Thr Glu Ile Asn Lys Lys Ile Tyr Lys Ile Gly 
        275                 280                 285             


Gln Gly Tyr Leu Ile Lys Asp Gly Lys Leu Ile Lys Asn Asn Ala Ser 
    290                 295                 300                 


Thr Asp Tyr Asp Leu Ser Asp Lys Ser Ile Asn Pro Leu Gly Gly Phe 
305                 310                 315                 320 


Val His Tyr Gly Glu Val Thr Asn Asp Phe Ile Met Leu Lys Gly Cys 
                325                 330                 335     


Val Val Gly Thr Lys Lys Arg Val Leu Thr Leu Arg Lys Ser Leu Leu 
            340                 345                 350         


Val Gln Thr Lys Arg Arg Ala Leu Glu Lys Ile Asp Leu Lys Phe Ile 
        355                 360                 365             


Asp Thr Thr Ser Lys Phe Gly His Gly Arg Phe Gln Thr Met Glu Glu 
    370                 375                 380                 


Lys Lys Ala Phe Met Gly Pro Leu Lys Lys Asp Arg Ile Ala Lys Glu 
385                 390                 395                 400 


Glu Gly Ala 
            


<210>  24
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  24
atgtctcaca gaaagttctc cgctcccaga catgggtccc tcggcttcct gcctcggaag       60

cgcagcagca ggcatcgtgg gaaggtgaag agcttcccta aggatgaccc gtccaagccg      120

gtccacctca cagccttcct gggatacaag gctggcatga ctcacatcgt gcgggaagtc      180

gacaggccgg gatccaaggt gaacaagaag gaggtggtgg aggctgtgac cattgtagag      240

acaccaccca tggtggttgt gggcattgtg ggctacgtgg aaacccctcg aggcctccgg      300

accttcaaga ctgtctttgc tgagcacatc agtgatgaat gcaagaggcg tttctataag      360

aattggcata aatctaagaa gaaggccttt accaagtact gcaagaaatg gcaggatgag      420

gatggcaaga agcagctgga gaaggacttc agcagcatga agaagtactg ccaagtcatc      480

cgtgtcattg cccacaccca gatgcgcctg cttcctctgc gccagaagaa ggcccacctg      540

atggagatcc aggtgaacgg aggcactgtg gccgagaagc tggactgggc ccgcgagagg      600

cttgagcagc aggtacctgt gaaccaagtg tttgggcagg atgagatgat cgacgtcatc      660

ggggtgacca agggcaaagg ctacaaaggg gtcaccagtc gttggcacac caagaagctg      720

ccccgcaaga cccaccgagg cctgcgcaag gtggcctgta ttggggcatg gcatcctgct      780

cgtgtagcct tctctgtggc acgcgctggg cagaaaggct accatcaccg cactgagatc      840

aacaagaaga tttataagat tggccagggc taccttatca aggacggcaa gctgatcaag      900

aacaatgcct ccactgacta tgacctatct gacaagagca tcaaccctct gggtggcttt      960

gtccactatg gtgaagtgac caatgacttt gtcatgctga aaggctgtgt ggtgggaacc     1020

aagaagcggg tgctcaccct ccgcaagtcc ttgctggtgc agacgaagcg gcgggctctg     1080

gagaagattg accttaagtt cattgacacc acctccaagt ttggccatgg ccgcttccag     1140

accatggagg agaagaaagc attcatggga ccactgaaga aagaccgaat tgcaaaggaa     1200

gaaggagctt aa                                                         1212


<210>  25
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  25

Met Glu Met Gly Arg Arg Ile His Ser Glu Leu Arg Asn Arg Ala Pro 
1               5                   10                  15      


Ser Asp Val Lys Glu Leu Ala Leu Asp Asn Ser Arg Ser Asn Glu Gly 
            20                  25                  30          


Lys Leu Glu Ala Leu Thr Asp Glu Phe Glu Glu Leu Glu Phe Leu Ser 
        35                  40                  45              


Lys Ile Asn Gly Gly Leu Thr Ser Ile Ser Asp Leu Pro Lys Leu Lys 
    50                  55                  60                  


Leu Arg Lys Leu Glu Leu Arg Val Ser Gly Gly Leu Glu Val Leu Ala 
65                  70                  75                  80  


Glu Lys Cys Pro Asn Leu Thr His Leu Tyr Leu Ser Gly Asn Lys Ile 
                85                  90                  95      


Lys Asp Leu Ser Thr Ile Glu Pro Leu Lys Gln Leu Glu Asn Leu Lys 
            100                 105                 110         


Ser Leu Asp Leu Phe Asn Cys Glu Val Thr Asn Leu Asn Asp Tyr Gly 
        115                 120                 125             


Glu Asn Val Phe Lys Leu Leu Leu Gln Leu Thr Tyr Leu Asp Ser Cys 
    130                 135                 140                 


Tyr Trp Asp His Lys Glu Ala Pro Tyr Ser Asp Ile Glu Asp His Val 
145                 150                 155                 160 


Glu Gly Leu Asp Asp Glu Glu Glu Gly Glu His Glu Glu Glu Tyr Asp 
                165                 170                 175     


Glu Asp Ala Gln Val Val Glu Asp Glu Glu Gly Glu Glu Glu Glu Glu 
            180                 185                 190         


Glu Gly Glu Glu Glu Asp Val Ser Gly Gly Asp Glu Glu Asp Glu Glu 
        195                 200                 205             


Gly Tyr Asn Asp Gly Glu Val Asp Gly Glu Glu Asp Glu Glu Glu Leu 
    210                 215                 220                 


Gly Glu Glu Glu Arg Gly Gln Lys Arg Lys 
225                 230                 


<210>  26
<211>  705
<212>  DNA
<213>  Homo sapiens

<400>  26
atggagatgg gcagacggat tcattcagag ctgcggaaca gggcgccctc tgatgtgaaa       60

gaacttgccc tggacaacag tcggtcgaat gaaggcaaac tcgaagccct cacagatgaa      120

tttgaagaac tggaattctt aagtaaaatc aacggaggcc tcacctcaat ctcagactta      180

ccaaagttaa agttgagaaa gcttgaacta agagtctcag ggggcctgga agtattggca      240

gaaaagtgtc caaacctcac gcatctatat ttaagtggca acaaaattaa agacctcagc      300

acaatagagc cactgaaaca gttagaaaac ctcaagagct tagacctttt caattgcgag      360

gtaaccaacc tgaacgacta cggagaaaac gtgttcaagc ttctcctgca actcacatat      420

ctcgacagct gttactggga ccacaaggag gccccttact cagatattga ggaccacgtg      480

gagggcctgg atgacgagga ggagggtgag catgaggagg agtatgatga agatgctcag      540

gtagtggaag atgaggaggg cgaggaggag gaggaggaag gtgaagagga ggacgtgagt      600

ggaggggacg aggaggatga agaaggttat aacgatggag aggtagatgg cgaggaagat      660

gaagaagagc ttggtgaaga agaaaggggt cagaagcgaa aatga                      705


<210>  27
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Lys His Ile Ile Asn Ser Tyr Glu Asn Ile Asn Asn Thr Ala Arg 
1               5                   10                  15      


Asn Asn Ser Asp Cys Pro Arg Val Val Leu Pro Glu Glu Ile Phe Phe 
            20                  25                  30          


Thr Ile Ser Ile Val Gly Val Leu Glu Asn Leu Ile Val Leu Leu Ala 
        35                  40                  45              


Val Phe Lys Asn Lys Asn Leu Gln Ala Pro Met Tyr Phe Phe Ile Cys 
    50                  55                  60                  


Ser Leu Ala Ile Ser Asp Met Leu Gly Ser Leu Tyr Lys Ile Leu Glu 
65                  70                  75                  80  


Asn Ile Leu Ile Ile Leu Arg Asn Met Gly Tyr Leu Lys Pro Arg Gly 
                85                  90                  95      


Ser Phe Glu Thr Thr Ala Asp Asp Ile Ile Asp Ser Leu Phe Val Leu 
            100                 105                 110         


Ser Leu Leu Gly Ser Ile Phe Ser Leu Ser Val Ile Ala Ala Asp Arg 
        115                 120                 125             


Tyr Ile Thr Ile Phe His Ala Leu Arg Tyr His Ser Ile Val Thr Met 
    130                 135                 140                 


Arg Arg Thr Val Val Val Leu Thr Val Ile Trp Thr Phe Cys Thr Gly 
145                 150                 155                 160 


Thr Gly Ile Thr Met Val Ile Phe Ser His His Val Pro Thr Val Ile 
                165                 170                 175     


Thr Phe Thr Ser Leu Phe Pro Leu Met Leu Val Phe Ile Leu Cys Leu 
            180                 185                 190         


Tyr Val His Met Phe Leu Leu Ala Arg Ser His Thr Arg Lys Ile Ser 
        195                 200                 205             


Thr Leu Pro Arg Ala Asn Met Lys Gly Ala Ile Thr Leu Thr Ile Leu 
    210                 215                 220                 


Leu Gly Val Phe Ile Phe Cys Trp Ala Pro Phe Val Leu His Val Leu 
225                 230                 235                 240 


Leu Met Thr Phe Cys Pro Ser Asn Pro Tyr Cys Ala Cys Tyr Met Ser 
                245                 250                 255     


Leu Phe Gln Val Asn Gly Met Leu Ile Met Cys Asn Ala Val Ile Asp 
            260                 265                 270         


Pro Phe Ile Tyr Ala Phe Arg Ser Pro Glu Leu Arg Asp Ala Phe Lys 
        275                 280                 285             


Lys Met Ile Phe Cys Ser Arg Tyr Trp 
    290                 295         


<210>  28
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Lys His Ile Ile Asn Ser Tyr Glu His Thr Asn Asp Thr Ala Arg 
1               5                   10                  15      


Asn Asn Ser Asp Cys Pro Asp Val Val Leu Pro Glu Glu Ile Phe Phe 
            20                  25                  30          


Thr Ile Ser Val Ile Gly Ile Leu Glu Asn Leu Ile Val Leu Leu Ala 
        35                  40                  45              


Val Ile Lys Asn Lys Asn Leu Gln Ser Pro Met Tyr Phe Phe Ile Cys 
    50                  55                  60                  


Ser Leu Ala Ile Ser Asp Met Leu Gly Ser Leu Tyr Lys Ile Leu Glu 
65                  70                  75                  80  


Asn Ile Leu Ile Met Phe Arg Asn Met Gly Tyr Leu Lys Pro Arg Gly 
                85                  90                  95      


Ser Phe Glu Ser Thr Ala Asp Asp Ile Ile Asp Cys Met Phe Ile Leu 
            100                 105                 110         


Ser Leu Leu Gly Ser Ile Phe Ser Leu Ser Val Ile Ala Ala Asp Arg 
        115                 120                 125             


Tyr Ile Thr Ile Phe His Ala Leu Gln Tyr His Ser Ile Val Thr Met 
    130                 135                 140                 


Arg Arg Thr Ile Ile Thr Leu Thr Ile Ile Trp Met Phe Cys Thr Gly 
145                 150                 155                 160 


Ser Gly Ile Thr Met Val Ile Phe Ser His His Ile Pro Thr Val Leu 
                165                 170                 175     


Thr Phe Thr Ser Leu Phe Pro Leu Met Leu Val Phe Ile Leu Cys Leu 
            180                 185                 190         


Tyr Ile His Met Phe Leu Leu Ala Arg Ser His Ala Arg Lys Ile Ser 
        195                 200                 205             


Thr Leu Pro Arg Thr Asn Met Lys Gly Ala Met Thr Leu Thr Ile Leu 
    210                 215                 220                 


Leu Gly Val Phe Ile Phe Cys Trp Ala Pro Phe Val Leu His Val Leu 
225                 230                 235                 240 


Leu Met Thr Phe Cys Pro Asn Asn Pro Tyr Cys Val Cys Tyr Met Ser 
                245                 250                 255     


Leu Phe Gln Val Asn Gly Met Leu Ile Met Cys Asn Ala Val Ile Asp 
            260                 265                 270         


Pro Phe Ile Tyr Ala Phe Arg Ser Pro Glu Leu Arg Asp Ala Phe Lys 
        275                 280                 285             


Arg Met Leu Phe Cys Asn Arg Tyr 
    290                 295     


<210>  29
<211>  894
<212>  DNA
<213>  Homo sapiens

<400>  29
atgaagcaca ttatcaactc gtatgaaaac atcaacaaca cagcaagaaa taattccgac       60

tgtcctcgtg tggttttgcc ggaggagata tttttcacaa tttccattgt tggagttttg      120

gagaatctga tcgtcctgct ggctgtgttc aagaataaga atctccaggc acccatgtac      180

tttttcatct gtagcttggc catatctgat atgctgggca gcctatataa gatcttggaa      240

aatatcctga tcatattgag aaacatgggc tatctcaagc cacgtggcag ttttgaaacc      300

acagccgatg acatcatcga ctccctgttt gtcctctccc tgcttggctc catcttcagc      360

ctgtctgtga ttgctgcgga ccgctacatc accatcttcc acgcactgcg gtaccacagc      420

atcgtgacca tgcgccgcac tgtggtggtg cttacggtca tctggacgtt ctgcacgggg      480

actggcatca ccatggtgat cttctcccat catgtgccca cagtgatcac cttcacgtcg      540

ctgttcccgc tgatgctggt cttcatcctg tgcctctatg tgcacatgtt cctgctggct      600

cgatcccaca ccaggaagat ctccaccctc cccagagcca acatgaaagg ggccatcaca      660

ctgaccatcc tgctcggggt cttcatcttc tgctgggccc cctttgtgct tcatgtcctc      720

ttgatgacat tctgcccaag taacccctac tgcgcctgct acatgtctct cttccaggtg      780

aacggcatgt tgatcatgtg caatgccgtc attgacccct tcatatatgc cttccggagc      840

ccagagctca gggacgcatt caaaaagatg atcttctgca gcaggtactg gtag            894


<210>  30
<211>  2979
<212>  DNA
<213>  Homo sapiens

<400>  30
atgcacaggt gtacagacca cctctgttga tgcgcgcgca ggagactgtg agcagatgcc       60

acactaggtg ggtgctggac tggagcctgg ggaagaacta gaggggctgg aagggcgcag      120

ggaggtctgc cagggtgaag ggacagccta ggggaaaccc agctcggaac ccacaaggca      180

gggcagctgg agcgtgcagt ctggtctccc cgtgttcaag ctctcactgt ggggcttcat      240

ctagtgcatg acacccctgg gagcacaaat gcctgctcct actgataaag aagcaggggg      300

agtgagcggc tcccaagcag cggcgcagga gcgaaggcag gtctagacat ccctgccctt      360

tttcccatca cagcagtctc tgcagttgct gctgaggtcg agtttccgaa ttgaggtgct      420

gctttgctcc ctttccaact caggctgctc taagctcttc cagaaagggg ctccagaggg      480

aactttgcca ggacagttgg agaactgccg agacaggcag ggttcctggt tccagagccc      540

cacgagaaag gggtctttgc tttgcacctt cctgcagcct agcagcgttc ctgcctcaga      600

gcaggacgag gcctggggtc ttctaggaaa gccctttgta cactgtcaag gggatcccca      660

cgccaaggcc atttacagcc tttgttcttc cagcctgcgg accctcctgc ctagccctgc      720

catgttcgca gcagccagcc agccagctct gcctctgccc gaggccaggg accccgacct      780

tagagcctgg ggtttctagg taggctgccc tgcttgcctg tggtttggac aggagagctg      840

ggcttggcac aagtgggtgc tggaaagagg cttcaatatg acggactttc cgtctctggt      900

taaatcacaa taaaccactg gaggagagct ttgaggctgt ggtttgaatc ctgggtgcca      960

ggagaccttt ctcccacctc gctttccttg ctggaaatga gggtacagta ggtgacccct     1020

caggtccctc tgagctacca ctctacaaat cactctgctc agattttagc tactgccatt     1080

aaggcacagt gcagagagtt taaaaattgc tgcagagttt aaaaattgcc tgacatacaa     1140

aaattagcca ggcgtggtgg cgggcgcctg tagccccagc tactcgggag gctgaggcag     1200

gaggatcact tgaatctggg aggcggaggt tgcagtgagc cgagcttgcg ccactacact     1260

ccagcttggg tgacagaatg agactttatc tccataaata aataatcgcc caacagcagg     1320

ctgggtctcc atacccagct tttccaggtt cacctctcgt ggctgttttc acatggatag     1380

ggaagacatg ggtcatcctt ccctcccaga ctccccccag gacactgccc ggccctctag     1440

acagcaggtg gagtcagcag agggagcagg gccttctttt tgtggttaat gatctctgtc     1500

ctaagcaatg ccatggcccc agactcacat acatctctaa taaccagcag aggactgttt     1560

cacagaaact gctgtgttcc agacaagcag ggacaccgat ttccctccca cttgccacgg     1620

gagatgggaa gaatgatacc agcagcagga atcctttttc tgggtgatcg aaagacaatt     1680

ttcagtttaa aaagcatcct tggaatggct gtgggtgaag ccttctcctg aggcctggga     1740

tgggctgact ttagcacttt ggctttctat gggtctttga agtgagatgg agtgaaaggc     1800

tgttctactc aggtgtcctc agacttggca cctggctaag tgctgtccct cgcccagatg     1860

ggaagaggct gcagtgactg gccctggagc tgatgttggc ctatccccca ggatggtttt     1920

agccacctgg ctgattgtgg aaacttctcc acaaaatgag atgaattata ctgtcctcaa     1980

cattctccca ataaatactc agaactacta tcagcttagg ccaaggcatg gtgattatac     2040

tttcgagaag gatagttaag cagagaatca caggatattt tctaactgac gaccggaggt     2100

gtgtgtgtgg aaggtatcca ggcctgggaa gttgacacag ggcagtgaga tgaggacagg     2160

ctaaagagcc atggtaggtt gaccccaaga ggccattgtg gagaatacaa gctgaaatgg     2220

ctcttgccaa cgcctgggac aagctattat tttatcccag gaatccagaa ccagaagaaa     2280

caagcaaatg aagtgatttt tttttttttt ttggagtgat ggagaacaat ggcagttttg     2340

ttttgtatac tgtgagctct caacagagtt ggatttattt ttctctcata taaaccccat     2400

cccccaaaca tttttttttt ttttttagag gtgatggtag cagacagtgc ttgtcactaa     2460

gtcctctctt ggggtggggg cagaggtggt gaggagcacc ggcttagggg aaaaggcagg     2520

caagtgagga gcaggccgaa gcctgggact gtggaggatg ttcgctctgt ttgcaggctg     2580

agctgcggaa ggtaaaaact ccaggccaaa ggattctaga aatatgggca caggggtcat     2640

attttcatga aaaaataaaa ataaaagcac agggtgggcc gggcacagtg gctcatgcct     2700

gtaatcccag cactttggga ggctgaggtg gatggctcac ctgaggtcag gagttcaaga     2760

ccagcctggc caacatggtg aaaccccgtc tctactaaaa atacaaaaat tagccgggca     2820

tggtggcact tgcctgtaag ctcagctact caggagcctg aggcaggaga atcgcttgaa     2880

cctgggaggc ggaggttgca gtgagctgag attgtgccac tgcactccag cctgggcaac     2940

aagagcgaaa ctgttttaaa aaaaaaaaaa aaaaaaaaa                            2979


<210>  31
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  31

Met Ala Asn Ala Ser Glu Pro Gly Gly Ser Gly Gly Gly Glu Ala Ala 
1               5                   10                  15      


Ala Leu Gly Leu Lys Leu Ala Thr Leu Ser Leu Leu Leu Cys Val Ser 
            20                  25                  30          


Leu Ala Gly Asn Val Leu Phe Ala Leu Leu Ile Val Arg Glu Arg Ser 
        35                  40                  45              


Leu His Arg Ala Pro Tyr Tyr Leu Leu Leu Asp Leu Cys Leu Ala Asp 
    50                  55                  60                  


Gly Leu Arg Ala Leu Ala Cys Leu Pro Ala Val Met Leu Ala Ala Arg 
65                  70                  75                  80  


Arg Ala Ala Ala Ala Ala Gly Ala Pro Pro Gly Ala Leu Gly Cys Lys 
                85                  90                  95      


Leu Leu Ala Phe Leu Ala Ala Leu Phe Cys Phe His Ala Ala Phe Leu 
            100                 105                 110         


Leu Leu Gly Val Gly Val Thr Arg Tyr Leu Ala Ile Ala His His Arg 
        115                 120                 125             


Phe Tyr Ala Glu Arg Leu Ala Gly Trp Pro Cys Ala Ala Met Leu Val 
    130                 135                 140                 


Cys Ala Ala Trp Ala Leu Ala Leu Ala Ala Ala Phe Pro Pro Val Leu 
145                 150                 155                 160 


Asp Gly Gly Gly Asp Asp Glu Asp Ala Pro Cys Ala Leu Glu Gln Arg 
                165                 170                 175     


Pro Asp Gly Ala Pro Gly Ala Leu Gly Phe Leu Leu Leu Leu Ala Val 
            180                 185                 190         


Val Val Gly Ala Thr His Leu Val Tyr Leu Arg Leu Leu Phe Phe Ile 
        195                 200                 205             


His Asp Arg Arg Lys Met Arg Pro Ala Arg Leu Val Pro Ala Val Ser 
    210                 215                 220                 


His Asp Trp Thr Phe His Gly Pro Gly Ala Thr Gly Gln Ala Ala Ala 
225                 230                 235                 240 


Asn Trp Thr Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Ala Leu Val 
                245                 250                 255     


Gly Ile Arg Pro Ala Gly Pro Gly Arg Gly Ala Arg Arg Leu Leu Val 
            260                 265                 270         


Leu Glu Glu Phe Lys Thr Glu Lys Arg Leu Cys Lys Met Phe Tyr Ala 
        275                 280                 285             


Val Thr Leu Leu Phe Leu Leu Leu Trp Gly Pro Tyr Val Val Ala Ser 
    290                 295                 300                 


Tyr Leu Arg Val Leu Val Arg Pro Gly Ala Val Pro Gln Ala Tyr Leu 
305                 310                 315                 320 


Thr Ala Ser Val Trp Leu Thr Phe Ala Gln Ala Gly Ile Asn Pro Val 
                325                 330                 335     


Val Cys Phe Leu Phe Asn Arg Glu Leu Arg Asp Cys Phe Arg Ala Gln 
            340                 345                 350         


Phe Pro Cys Cys Gln Ser Pro Arg Thr Thr Gln Ala Thr His Pro Cys 
        355                 360                 365             


Asp Leu Lys Gly Ile Gly Leu 
    370                 375 


<210>  32
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Asn Ala Ser Glu Pro Gly Gly Ser Gly Gly Gly Glu Ala Ala 
1               5                   10                  15      


Ala Leu Gly Leu Lys Leu Ala Thr Leu Ser Leu Leu Leu Cys Val Ser 
            20                  25                  30          


Leu Ala Gly Asn Val Leu Phe Ala Leu Leu Ile Val Arg Glu Arg Ser 
        35                  40                  45              


Leu His Arg Ala Pro Tyr Tyr Leu Leu Leu Asp Leu Cys Leu Ala Asp 
    50                  55                  60                  


Gly Leu Arg Ala Leu Ala Cys Leu Pro Ala Val Met Leu Ala Ala Arg 
65                  70                  75                  80  


Arg Ala Ala Ala Ala Ala Gly Ala Pro Pro Gly Ala Leu Gly Cys Lys 
                85                  90                  95      


Leu Leu Ala Phe Leu Ala Ala Leu Phe Cys Phe His Ala Ala Phe Leu 
            100                 105                 110         


Leu Leu Gly Val Gly Val Thr Arg Tyr Leu Ala Ile Ala His His Arg 
        115                 120                 125             


Phe Tyr Ala Glu Arg Leu Ala Gly Trp Pro Cys Ala Ala Met Leu Val 
    130                 135                 140                 


Cys Ala Ala Trp Ala Leu Ala Leu Ala Ala Ala Phe Pro Pro Val Leu 
145                 150                 155                 160 


Asp Gly Gly Gly Asp Asp Glu Asp Ala Pro Cys Ala Leu Glu Gln Arg 
                165                 170                 175     


Pro Asp Gly Ala Pro Gly Ala Leu Gly Phe Leu Leu Leu Leu Ala Val 
            180                 185                 190         


Val Val Gly Ala Thr His Leu Val Tyr Leu Arg Leu Leu Phe Phe Ile 
        195                 200                 205             


His Asp Arg Arg Lys Met Arg Pro Ala Arg Leu Val Pro Ala Val Ser 
    210                 215                 220                 


His Asp Trp Thr Phe His Gly Pro Gly Ala Thr Gly Gln Ala Ala Ala 
225                 230                 235                 240 


Asn Trp Thr Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Ala Leu Val 
                245                 250                 255     


Gly Ile Arg Pro Ala Gly Pro Gly Arg Gly Ala Arg Arg Leu Leu Val 
            260                 265                 270         


Leu Glu Glu Phe Lys Thr Glu Lys Arg Leu Cys Lys Met Phe Tyr Ala 
        275                 280                 285             


Val Thr Leu Leu Phe Leu Leu Leu Trp Gly Pro Tyr Val Val Ala Ser 
    290                 295                 300                 


Tyr Leu Arg Val Leu Val Arg Pro Gly Ala Val Pro Gln Ala Tyr Leu 
305                 310                 315                 320 


Thr Ala Ser Val Trp Leu Thr Phe Ala Gln Ala Gly Ile Asn Pro Val 
                325                 330                 335     


Val Cys Phe Leu Phe Asn Arg Glu Leu Arg Asp Cys Phe Arg Ala Gln 
            340                 345                 350         


Phe Pro Cys Cys Gln Ser Pro Arg Thr Thr Gln Ala Thr His Pro Cys 
        355                 360                 365             


Asp Leu Lys Gly Ile Gly Leu 
    370                 375 


<210>  33
<211>  1128
<212>  DNA
<213>  Homo sapiens

<400>  33
atggcgaacg cgagcgagcc gggtggcagc ggcggcggcg aggcggccgc cctgggcctc       60

aagctggcca cgctcagcct gctgctgtgc gtgagcctag cgggcaacgt gctgttcgcg      120

ctgctgatcg tgcgggagcg cagcctgcac cgcgccccgt actacctgct gctcgacctg      180

tgcctggccg acgggctgcg cgcgctcgcc tgcctcccgg ccgtcatgct ggcggcgcgg      240

cgtgcggcgg ccgcggcggg ggcgccgccg ggcgcgctgg gctgcaagct gctcgccttc      300

ctggccgcgc tcttctgctt ccacgccgcc ttcctgctgc tgggcgtggg cgtcacccgc      360

tacctggcca tcgcgcacca ccgcttctat gcagagcgcc tggccggctg gccgtgcgcc      420

gccatgctgg tgtgcgccgc ctgggcgctg gcgctggccg cggccttccc gccagtgctg      480

gacggcggtg gcgacgacga ggacgcgccg tgcgccctgg agcagcggcc cgacggcgcc      540

cccggcgcgc tgggcttcct gctgctgctg gccgtggtgg tgggcgccac gcacctcgtc      600

tacctccgcc tgctcttctt catccacgac cgccgcaaga tgcggcccgc gcgcctggtg      660

cccgccgtca gccacgactg gaccttccac ggcccgggcg ccaccggcca ggcggccgcc      720

aactggacgg cgggcttcgg ccgcgggccc acgccgcccg cgcttgtggg catccggccc      780

gcagggccgg gccgcggcgc gcgccgcctc ctcgtgctgg aagaattcaa gacggagaag      840

aggctgtgca agatgttcta cgccgtcacg ctgctcttcc tgctcctctg ggggccctac      900

gtcgtggcca gctacctgcg ggtcctggtg cggcccggcg ccgtccccca ggcctacctg      960

acggcctccg tgtggctgac cttcgcgcag gccggcatca accccgtcgt gtgcttcctc     1020

ttcaacaggg agctgaggga ctgcttcagg gcccagttcc cctgctgcca gagcccccgg     1080

accacccagg cgacccatcc ctgcgacctg aaaggcattg gtttatga                  1128


<210>  34
<211>  1129
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Phe Val Pro Val Ile Pro Glu Ser Tyr Ser His Val Leu Ala 
1               5                   10                  15      


Glu Phe Glu Ser Leu Asp Pro Leu Leu Ser Ala Leu Arg Leu Asp Ser 
            20                  25                  30          


Ser Arg Leu Lys Cys Thr Ser Ile Ala Val Ser Arg Lys Trp Leu Ala 
        35                  40                  45              


Leu Gly Ser Ser Gly Gly Gly Leu His Leu Ile Gln Lys Glu Gly Trp 
    50                  55                  60                  


Lys His Arg Leu Phe Leu Ser His Arg Glu Gly Ala Ile Ser Gln Val 
65                  70                  75                  80  


Ala Cys Cys Leu His Asp Asp Asp Tyr Val Ala Val Ala Thr Ser Gln 
                85                  90                  95      


Gly Leu Val Val Val Trp Glu Leu Asn Gln Glu Arg Arg Gly Lys Pro 
            100                 105                 110         


Glu Gln Met Tyr Val Ser Ser Glu His Lys Gly Arg Arg Val Thr Ala 
        115                 120                 125             


Leu Cys Trp Asp Thr Ala Ile Leu Arg Val Phe Val Gly Asp His Ala 
    130                 135                 140                 


Gly Lys Val Ser Ala Ile Lys Leu Asn Thr Ser Lys Gln Ala Lys Ala 
145                 150                 155                 160 


Ala Ala Ala Phe Val Met Phe Pro Val Gln Thr Ile Thr Thr Val Asp 
                165                 170                 175     


Ser Cys Val Val Gln Leu Asp Tyr Leu Asp Gly Arg Leu Leu Ile Ser 
            180                 185                 190         


Ser Leu Thr Arg Ser Phe Leu Cys Asp Thr Glu Arg Glu Lys Phe Trp 
        195                 200                 205             


Lys Ile Gly Asn Lys Glu Arg Asp Gly Glu Tyr Gly Ala Cys Phe Phe 
    210                 215                 220                 


Pro Gly Arg Cys Ser Gly Gly Gln Gln Pro Leu Ile Tyr Cys Ala Arg 
225                 230                 235                 240 


Pro Gly Ser Arg Met Trp Glu Val Asn Phe Asp Gly Glu Val Ile Ser 
                245                 250                 255     


Thr His Gln Phe Lys Lys Leu Leu Ser Leu Pro Pro Leu Pro Val Ile 
            260                 265                 270         


Thr Leu Arg Ser Glu Pro Gln Tyr Asp His Thr Ala Gly Ser Ser Gln 
        275                 280                 285             


Ser Leu Ser Phe Pro Lys Leu Leu His Leu Ser Glu His Cys Val Leu 
    290                 295                 300                 


Thr Trp Thr Glu Arg Gly Ile Tyr Ile Phe Ile Pro Gln Asn Val Gln 
305                 310                 315                 320 


Val Leu Leu Trp Ser Glu Val Lys Asp Ile Gln Asp Val Ala Val Cys 
                325                 330                 335     


Arg Asn Glu Leu Phe Cys Leu His Leu Asn Gly Lys Val Ser His Leu 
            340                 345                 350         


Ser Leu Ile Ser Val Glu Arg Cys Val Glu Arg Leu Leu Arg Arg Gly 
        355                 360                 365             


Leu Trp Asn Leu Ala Ala Arg Thr Cys Cys Leu Phe Gln Asn Ser Val 
    370                 375                 380                 


Ile Ala Ser Arg Ala Arg Lys Thr Leu Thr Ala Asp Lys Leu Glu His 
385                 390                 395                 400 


Leu Lys Ser Gln Leu Asp His Gly Thr Tyr Asn Asp Leu Ile Ser Gln 
                405                 410                 415     


Leu Glu Glu Leu Ile Leu Lys Phe Glu Pro Leu Asp Ser Ala Cys Ser 
            420                 425                 430         


Ser Arg Arg Ser Ser Ile Ser Ser His Glu Ser Phe Ser Ile Leu Asp 
        435                 440                 445             


Ser Gly Ile Tyr Arg Ile Ile Ser Ser Arg Arg Gly Ser Gln Ser Asp 
    450                 455                 460                 


Glu Asp Ser Cys Ser Leu His Ser Gln Thr Leu Ser Glu Asp Glu Arg 
465                 470                 475                 480 


Phe Lys Glu Phe Thr Ser Gln Gln Glu Glu Asp Leu Pro Asp Gln Cys 
                485                 490                 495     


Cys Gly Ser His Gly Asn Glu Asp Asn Val Ser His Ala Pro Val Met 
            500                 505                 510         


Phe Glu Thr Asp Lys Asn Glu Thr Phe Leu Pro Phe Gly Ile Pro Leu 
        515                 520                 525             


Pro Phe Arg Ser Pro Ser Pro Leu Val Ser Leu Gln Ala Val Lys Glu 
    530                 535                 540                 


Ser Val Ser Ser Phe Val Arg Lys Thr Thr Glu Lys Ile Gly Thr Leu 
545                 550                 555                 560 


His Thr Ser Pro Asp Leu Lys Val Arg Pro Glu Leu Arg Gly Asp Glu 
                565                 570                 575     


Gln Ser Cys Glu Glu Asp Val Ser Ser Asp Thr Cys Pro Lys Glu Glu 
            580                 585                 590         


Asp Thr Glu Glu Glu Lys Glu Val Thr Ser Pro Pro Pro Glu Glu Asp 
        595                 600                 605             


Arg Phe Gln Glu Leu Lys Val Ala Thr Ala Glu Ala Met Thr Lys Leu 
    610                 615                 620                 


Gln Asp Pro Leu Val Leu Phe Glu Ser Glu Ser Leu Arg Met Val Leu 
625                 630                 635                 640 


Gln Glu Trp Leu Ser His Leu Glu Lys Thr Phe Ala Met Lys Asp Phe 
                645                 650                 655     


Ser Gly Val Ser Asp Thr Asp Asn Ser Ser Met Lys Leu Asn Gln Asp 
            660                 665                 670         


Val Leu Leu Val Asn Glu Ser Lys Lys Gly Ile Leu Asp Glu Asp Asn 
        675                 680                 685             


Glu Lys Glu Lys Arg Asp Ser Leu Gly Asn Glu Glu Ser Val Asp Lys 
    690                 695                 700                 


Thr Ala Cys Glu Cys Val Arg Ser Pro Arg Glu Ser Leu Asp Asp Leu 
705                 710                 715                 720 


Phe Gln Ile Cys Ser Pro Cys Ala Ile Ala Ser Gly Leu Arg Asn Asp 
                725                 730                 735     


Leu Ala Glu Leu Thr Thr Leu Cys Leu Glu Leu Asn Val Leu Asn Ser 
            740                 745                 750         


Lys Ile Lys Ser Thr Ser Gly His Val Asp His Thr Leu Gln Gln Tyr 
        755                 760                 765             


Ser Pro Glu Ile Leu Ala Cys Gln Phe Leu Lys Lys Tyr Phe Phe Leu 
    770                 775                 780                 


Leu Asn Leu Lys Arg Ala Lys Glu Ser Ile Lys Leu Ser Tyr Ser Asn 
785                 790                 795                 800 


Ser Pro Ser Val Trp Asp Thr Phe Ile Glu Gly Leu Lys Glu Met Ala 
                805                 810                 815     


Ser Ser Asn Pro Val Tyr Met Glu Met Glu Lys Gly Asp Leu Pro Thr 
            820                 825                 830         


Arg Leu Lys Leu Leu Asp Asp Glu Val Pro Phe Asp Ser Pro Leu Leu 
        835                 840                 845             


Val Val Tyr Ala Thr Arg Leu Tyr Glu Lys Phe Gly Glu Ser Ala Leu 
    850                 855                 860                 


Arg Ser Leu Ile Lys Phe Phe Pro Ser Ile Leu Pro Ser Asp Ile Ile 
865                 870                 875                 880 


Gln Leu Cys His His His Pro Ala Glu Phe Leu Ala Tyr Leu Asp Ser 
                885                 890                 895     


Leu Val Lys Ser Arg Pro Glu Asp Gln Arg Ser Ser Phe Leu Glu Ser 
            900                 905                 910         


Leu Leu Gln Pro Glu Ser Leu Arg Leu Asp Trp Leu Leu Leu Ala Val 
        915                 920                 925             


Ser Leu Asp Ala Pro Pro Ser Thr Ser Thr Met Asp Asp Glu Gly Tyr 
    930                 935                 940                 


Pro Arg Pro His Ser His Leu Leu Ser Trp Gly Tyr Ser Gln Leu Ile 
945                 950                 955                 960 


Leu His Leu Ile Lys Leu Pro Ala Asp Phe Ile Thr Lys Glu Lys Met 
                965                 970                 975     


Thr Asp Ile Cys Arg Ser Cys Gly Phe Trp Pro Gly Tyr Leu Ile Leu 
            980                 985                 990         


Cys Leu Glu Leu Glu Arg Arg Arg  Glu Ala Phe Thr Asn  Ile Val Tyr 
        995                 1000                 1005             


Leu Asn  Asp Met Ser Leu Met  Glu Gly Asp Asn Gly  Trp Ile Pro 
    1010                 1015                 1020             


Glu Thr  Val Glu Glu Trp Lys  Leu Leu Leu His Leu  Ile Gln Ser 
    1025                 1030                 1035             


Lys Ser  Thr Arg Pro Ala Pro  Gln Glu Ser Leu Asn  Gly Ser Leu 
    1040                 1045                 1050             


Ser Asp  Gly Pro Ser Pro Ile  Asn Val Glu Asn Val  Ala Leu Leu 
    1055                 1060                 1065             


Leu Ala  Lys Ala Met Gly Pro  Asp Arg Ala Trp Ser  Leu Leu Gln 
    1070                 1075                 1080             


Glu Cys  Gly Leu Ala Leu Glu  Leu Ser Glu Lys Phe  Thr Arg Thr 
    1085                 1090                 1095             


Cys Asp  Ile Leu Arg Ile Ala  Glu Lys Arg Gln Arg  Ala Leu Ile 
    1100                 1105                 1110             


Gln Ser  Met Leu Glu Lys Cys  Asp Arg Phe Leu Trp  Ser Gln Gln 
    1115                 1120                 1125             


Ala 
    


<210>  35
<211>  1126
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Thr Phe Val Pro Val Ile Pro Glu Ala Tyr Ser His Val Leu Ala 
1               5                   10                  15      


Glu Phe Glu Ser Leu Asp Pro Leu Leu Thr Ala Leu Arg Leu Asp Ser 
            20                  25                  30          


Ser Arg Leu Arg Cys Thr Ser Ile Ala Val Ser Arg Lys Trp Leu Ala 
        35                  40                  45              


Leu Gly Ser Thr Gly Gly Gly Leu Asn Leu Ile Gln Lys Asp Gly Trp 
    50                  55                  60                  


Lys Gln Arg Leu Phe Leu Ser His Arg Glu Gly Ala Ile Ser Gln Ile 
65                  70                  75                  80  


Ala Cys Cys Ser His Asp Asp Asp Tyr Val Ala Val Ala Thr Ser Gln 
                85                  90                  95      


Gly Leu Val Val Val Trp Glu Leu Asn Gln Glu Arg Arg Gly Lys Pro 
            100                 105                 110         


Glu Arg Ile His Val Ser Ser Glu His Lys Gly Arg Lys Val Thr Ala 
        115                 120                 125             


Leu Cys Trp Asp Thr Ala Val Leu Arg Val Phe Val Gly Asp His Val 
    130                 135                 140                 


Gly Lys Val Ser Ala Ile Lys Leu Asn Thr Leu Lys Gln Ala Lys Ala 
145                 150                 155                 160 


Ala Ala Ala Phe Val Met Phe Pro Val Gln Thr Val Leu Thr Val Asp 
                165                 170                 175     


Ser Cys Val Val Gln Leu Asp Tyr Leu Asp Gly Arg Leu Leu Val Ser 
            180                 185                 190         


Ser Leu Thr Arg Ser Phe Leu Cys Asp Thr Glu Arg Glu Lys Phe Trp 
        195                 200                 205             


Lys Ile Gly Asn Lys Glu Arg His Gly Glu Tyr Gly Ala Cys Phe Phe 
    210                 215                 220                 


Pro Gly Arg Cys Ala Gly Gly Gln Gln Pro Val Ile Tyr Cys Ala Arg 
225                 230                 235                 240 


Pro Gly Ser Arg Met Trp Glu Val Asn Phe Asp Gly Glu Val Leu Ser 
                245                 250                 255     


Thr His Gln Phe Lys Lys Leu Leu Ser Met Pro Pro Leu Pro Val Ile 
            260                 265                 270         


Thr Ala Arg Ser Glu Pro Gln Tyr Asp His Thr Val Gly Ser Ser Gln 
        275                 280                 285             


Ser Leu Ala Phe Pro Lys Leu Leu His Leu Ser Glu His Cys Val Leu 
    290                 295                 300                 


Thr Trp Thr Glu Lys Gly Ile Tyr Ile Phe Ile Pro Gln Asn Val Gln 
305                 310                 315                 320 


Val Leu Leu Trp Ser Glu Val Lys Asp Ile Gln Asp Val Ala Val Tyr 
                325                 330                 335     


Lys Asn Glu Leu Phe Cys Leu His Phe Asn Gly Lys Ile Ser His Leu 
            340                 345                 350         


Ser Leu Leu Ser Val Glu Arg Cys Val Glu Arg Leu Leu Arg Arg Gly 
        355                 360                 365             


Leu Trp Asp Leu Ala Ala Arg Thr Cys Cys Leu Phe Gln Asn Ser Ile 
    370                 375                 380                 


Ile Thr Ser Arg Ala Arg Lys Thr Leu Thr Ala Asp Lys Leu Glu His 
385                 390                 395                 400 


Leu Lys Ser Gln Leu Asp Leu Thr Ala Cys Ser Glu Leu Ile Ser Gln 
                405                 410                 415     


Leu Asp Asp Leu Ile Leu Arg Phe Glu Pro Leu Glu Ser Ala Cys Ser 
            420                 425                 430         


Ser Arg Arg Ser Ser Ile Ser Ser His Glu Ser Phe Ser Ile Leu Asp 
        435                 440                 445             


Ser Gly Ile Tyr Arg Ile Ile Ser Ser Arg Arg Gly Ser Gln Ser Asp 
    450                 455                 460                 


Glu Asp Ser Cys Ser Leu His Ser Gln Thr Phe Ser Glu Asp Glu Arg 
465                 470                 475                 480 


Leu Lys Glu Phe Ala Ser His Gln Glu Glu Glu Gln Pro Glu Gln Gly 
                485                 490                 495     


Cys Gly Ala Asn Arg Asn Glu Glu Ser Ala Ser His Ser Pro Val Met 
            500                 505                 510         


Ser Glu Val Asp Lys Ser Glu Ala Phe Leu Pro Phe Ser Ile Ala Leu 
        515                 520                 525             


Pro Phe Arg Ser Pro Ser Pro Leu Val Ser Leu Gln Ala Val Lys Asp 
    530                 535                 540                 


Ser Val Ser Ser Phe Val Arg Lys Thr Thr Glu Lys Ile Gly Thr Leu 
545                 550                 555                 560 


His Gly Ser Pro Glu Leu Lys Glu Pro Phe Glu Ser Lys Asp Ala Asp 
                565                 570                 575     


Arg Ala His Glu Glu Glu Val Ser Ala Val Thr Cys Pro Leu Glu Glu 
            580                 585                 590         


Asp Thr Glu Glu Lys Glu Ile His Gln Pro Pro Lys Glu Asp Arg Leu 
        595                 600                 605             


Gln Glu Leu Thr Ala Ala Thr Ala Glu Ala Met Thr Lys Leu Leu Asp 
    610                 615                 620                 


Pro Leu Val Leu Phe Glu Pro Lys Val Leu Arg Met Val Leu Leu Glu 
625                 630                 635                 640 


Trp Leu Ser Gln Leu Glu Lys Thr Phe Ala Met Lys Asp Phe Pro Gly 
                645                 650                 655     


Ile Ser Asn Thr Ser Ser Pro Thr Val Lys Ser Asn Leu Gly Ala His 
            660                 665                 670         


Leu Leu Gly Glu Thr Glu Lys Arg Val Leu Asp Glu Glu Ser Gly Glu 
        675                 680                 685             


Gly Arg Arg Val Ser Leu Val Thr Glu Glu Ala Gly Gly Gln Ile Thr 
    690                 695                 700                 


Cys Asp Pro Val Ser Asn Leu Ser Glu Pro Ser Ala Asp Arg Phe Arg 
705                 710                 715                 720 


Val Cys Ser Pro Tyr Ala Ile Thr Asn Ser Leu Gln Arg Asp Leu Ala 
                725                 730                 735     


Glu Leu Thr Thr Leu Cys Leu Glu Leu Asn Val Leu Thr Ser Ala Met 
            740                 745                 750         


Glu Ser Val Gly Gly His Val Asp Arg Ala Ser Gln Gln Leu Ser Pro 
        755                 760                 765             


Glu Ile Leu Ala Cys Arg Phe Leu Lys Lys Tyr Phe Phe Leu Leu Asp 
    770                 775                 780                 


Leu Lys Arg Ala Lys Glu Ser Ile Lys Leu Thr Tyr Asp Ser Pro Cys 
785                 790                 795                 800 


Val Trp Asp Thr Phe Val Glu Gly Leu Lys Glu Met Ala Arg Ser Asn 
                805                 810                 815     


Pro Ala Tyr Thr Glu Leu Glu Glu Gly Asp Leu Pro Thr Gly Leu Gln 
            820                 825                 830         


Leu Leu Asp Gly Ser Val Pro Ser Asp Ser Pro Leu Leu Ile Ala Phe 
        835                 840                 845             


Ala Thr Arg Leu Tyr Asp Arg Phe Gly Glu Ser Ala Leu Arg Ala Cys 
    850                 855                 860                 


Ile Lys Phe Tyr Pro Ser Ile Ser Pro Ser Asp Ile Ala Gln Leu Cys 
865                 870                 875                 880 


Arg His His Pro Ala Gln Phe Leu Ala Tyr Leu Asp Ser Leu Val Lys 
                885                 890                 895     


Ser Arg Pro Glu Asp Gln Trp Pro Ser Phe Leu Glu Phe Leu Leu Gln 
            900                 905                 910         


Pro Glu Ser Leu Arg Leu Glu Trp Leu Leu Leu Ala Val Ser His Asp 
        915                 920                 925             


Ala Pro Pro Ser Thr Ser Thr Val Asp Asp Glu Gly His Pro Arg Pro 
    930                 935                 940                 


His Ser His Leu Leu Ser Trp Gly Tyr Ser Gln Leu Ile Leu Leu Leu 
945                 950                 955                 960 


Ile Lys Leu Pro Ala Asp Phe Thr Thr Lys Glu Lys Met Thr Asp Ile 
                965                 970                 975     


Cys Arg Ser Tyr Gly Phe Trp Pro Gly Tyr Leu Thr Leu Cys Leu Glu 
            980                 985                 990         


Leu Glu Arg Arg Arg Glu Ala Phe  Thr Asn Ile Val Tyr  Leu Asn Asp 
        995                 1000                 1005             


Ile Ser  Leu Met Glu Gly Asp  Asn Gly Trp Ile Pro  Glu Thr Leu 
    1010                 1015                 1020             


Glu Glu  Trp Lys Leu Leu Leu  His Leu Leu Gln Thr  Lys Ser Thr 
    1025                 1030                 1035             


Arg Pro  Ala Pro Gln Glu Ser  Leu Asn Gly Ser Leu  Ser Asp Gly 
    1040                 1045                 1050             


Pro Ala  Pro Ile Asn Val Glu  Asn Val Ala Leu Leu  Leu Ala Lys 
    1055                 1060                 1065             


Ala Met  Gly Pro Asp Arg Ala  Trp Ser Leu Leu Gln  Glu Cys Gly 
    1070                 1075                 1080             


Leu Ala  Leu Glu Leu Ser Glu  Lys Phe Thr Arg Thr  Cys Asp Ile 
    1085                 1090                 1095             


Leu Arg  Ile Ala Glu Arg Arg  Gln Arg Ala Leu Ile  Gln Gly Met 
    1100                 1105                 1110             


Leu Glu  Lys Cys Asp Arg Phe  Leu Trp Ser Gln Gln  Ala 
    1115                 1120                 1125     


<210>  36
<211>  3390
<212>  DNA
<213>  Homo sapiens

<400>  36
atggcttttg tgccagtgat accagagtcc tacagccatg ttcttgcaga gtttgaatct       60

ctggatccat tactctcagc cctgcggctg gactccagtc gtctaaagtg cacgagcata      120

gctgtgtctc ggaaatggtt ggctttgggc agttcaggag gaggactcca tctcattcag      180

aaagaaggct ggaagcacag gctttttctt tcacacaggg aaggtgcaat ttctcaagtc      240

gcctgttgtt tacatgatga tgattatgtt gctgtagcta ccagtcaagg tcttgtggtt      300

gtttgggaat taaatcaaga gcgtcgtggg aaaccggaac aaatgtatgt gtcttcagaa      360

cacaaaggcc gaagagtcac agctctctgc tgggatacag ctattcttag agtttttgta      420

ggtgatcatg ctgggaaggt ttctgctatc aaactcaata cttctaaaca agcaaaggca      480

gctgctgctt ttgtgatgtt tcctgttcag acaatcacaa ctgttgactc ctgtgttgta      540

cagttagatt atttggatgg aaggctactt atatcttcac ttactcgatc cttcttgtgt      600

gacactgaga gagaaaagtt ttggaaaatt ggaaacaagg aaagagatgg agaatatgga      660

gcttgtttct ttcctggaag atgttctggg ggccagcaac ctctgatata ttgtgctcgc      720

ccaggctcta ggatgtggga agtgaacttt gatggagaag ttataagtac acatcagttc      780

aagaaactcc tctcgttgcc acctctccct gtgattactc tcagatcaga acctcagtat      840

gatcatacag ctggatcctc ccagtctttg tctttcccca aactcttaca tcttagtgag      900

cattgtgtgc tgacttggac agaaagagga atttatattt tcattcctca gaatgttcaa      960

gttcttcttt ggagtgaagt caaagatatt caggatgtgg ctgtctgtag gaatgaattg     1020

ttctgtttgc acctaaatgg gaaagtctca catctctccc tgatatctgt ggagcgctgt     1080

gtggaacgcc tgctaagaag aggcctatgg aacttggctg ctcgtacatg ctgtcttttc     1140

caaaattctg tcattgccag cagagcaaga aaaactttga ctgcagataa attggagcat     1200

ttgaaatctc agctggacca tggcacctac aatgatctaa tttctcaact ggaagaattg     1260

atcttaaaat ttgaaccttt ggattcagct tgtagcagta gaagaagctc catttcatca     1320

catgaaagtt tcagcatctt ggactctggt atttatcgta tcattagtag tagaagaggc     1380

agtcagtcag atgaagactc ttgctccctt cacagccaaa ccctctcaga agatgagaga     1440

tttaaagaat tcacctcaca gcaggaagag gacctgccag atcagtgttg tggctcacac     1500

ggaaatgaag acaatgtttc tcatgctcca gtgatgtttg agacagataa gaatgaaact     1560

tttctcccgt tcggcattcc attaccattt cgttctccat ctcctcttgt gtctcttcag     1620

gctgtcaaag aaagtgtttc tagctttgtg cgtaaaacta ctgagaagat tggcaccctt     1680

cacacgagcc ctgatctgaa agtgagacca gagctcaggg gtgatgagca atcatgtgaa     1740

gaggatgtga gttcagatac ctgcccaaag gaggaagaca ctgaggagga aaaagaggta     1800

actagtccac ctccagaaga agacaggttc caggagctta aagtagcaac agcagaagca     1860

atgaccaagc tacaggaccc tctggtttta tttgaatccg agtctctgag aatggtttta     1920

caggagtggc tttcacattt agaaaaaaca tttgccatga aggacttttc aggtgtttca     1980

gatactgaca actcatccat gaaattgaac caggatgtgc tattagttaa tgaatcaaaa     2040

aagggaatat tagatgaaga taatgaaaaa gaaaaaaggg actctttagg caatgaagaa     2100

tctgttgata aaacagcatg tgaatgtgta aggagtccaa gggagtcttt ggatgacctg     2160

tttcaaatat gttctccatg cgccattgca agtggtcttc ggaacgacct ggctgaattg     2220

acaacattat gtttggagtt gaatgtattg aattctaaga tcaaaagcac cagtggacat     2280

gtggaccaca ctttgcaaca gtactctcct gaaattctgg cttgccagtt cctgaagaag     2340

tacttttttc tcctgaactt gaaaagagcg aaggagagta tcaagcttag ttacagtaat     2400

agcccttctg tttgggatac ttttattgaa ggattgaaag aaatggcaag ttccaatcct     2460

gtgtatatgg agatggaaaa aggagatcta ccaacaaggt taaagttact agatgacgag     2520

gttccttttg atagtccgtt gttggttgtt tatgctaccc ggttgtatga aaagtttggg     2580

gagtctgctc ttcgatcctt aatcaagttc tttccatcca ttttgccatc ggatatcata     2640

caactttgtc atcatcatcc tgctgagttt ttggcctatt tagacagtct ggtgaaatca     2700

aggcctgaag atcagcggtc atcttttctt gagtcccttc tgcaaccaga gtctttaagg     2760

ttggattggc tgcttttggc agtgtccctt gatgctccac caagcaccag cacaatggat     2820

gatgaaggtt atcccaggcc tcattcacac ttgctttcct ggggttacag tcagctgatc     2880

cttcatctaa ttaaacttcc tgcagatttt ataaccaaag agaaaatgac agacatctgc     2940

aggtcttgtg gtttctggcc tggatatcta attctctgtt tggagctgga gagaagaaga     3000

gaggccttca ccaatattgt gtatctgaat gatatgagcc tgatggaagg ggacaatggt     3060

tggatcccag agaccgtgga ggaatggaag cttctccttc atctcataca gagcaagagc     3120

acgaggccag ccccccagga gtcactaaat gggagcctca gtgatgggcc ttcccccatc     3180

aatgtggaga atgtggcact tctgttagct aaggccatgg gcccagatcg ggcttggtca     3240

ctgctacagg aatgtggtct ggcccttgag ttgtcagaga agtttaccag aacctgcgat     3300

atcctgagga ttgctgagaa aaggcagagg gccttgatac aaagcatgct tgaaaaatgc     3360

gatcggtttc tctggtccca gcaggcctag                                      3390


<210>  37
<211>  3048
<212>  DNA
<213>  Homo sapiens

<400>  37
atgtatgtgt cttcagaaca caaaggccga agagtcacag ctctctgctg ggatacagct       60

attcttagag tttttgtagg tgatcatgct gggaaggttt ctgctatcaa actcaatact      120

tctaaacaag caaaggcagc tgctgctttt gtgatgtttc ctgttcagac aatcacaact      180

gttgactcct gtgttgtaca gttagattat ttggatggaa ggctacttat atcttcactt      240

actcgatcct tcttgtgtga cactgagaga gaaaagtttt ggaaaattgg aaacaaggaa      300

agagatggag aatatggagc ttgtttcttt cctggaagat gttctggggg ccagcaacct      360

ctgatatatt gtgctcgccc aggctctagg atgtgggaag tgaactttga tggagaagtt      420

ataagtacac atcagttcaa gaaactcctc tcgttgccac ctctccctgt gattactctc      480

agatcagaac ctcagtatga tcatacagct ggatcctccc agtctttgtc tttccccaaa      540

ctcttacatc ttagtgagca ttgtgtgctg acttggacag aaagaggaat ttatattttc      600

attcctcaga atgttcaagt tcttctttgg agtgaagtca aagatattca ggatgtggct      660

gtctgtagga atgaattgtt ctgtttgcac ctaaatggga aagtctcaca tctctccctg      720

atatctgtgg agcgctgtgt ggaacgcctg ctaagaagag gcctatggaa cttggctgct      780

cgtacatgct gtcttttcca aaattctgtc attgccagca gagcaagaaa aactttgact      840

gcagataaat tggagcattt gaaatctcag ctggaccatg gcacctacaa tgatctaatt      900

tctcaactgg aagaattgat cttaaaattt gaacctttgg attcagcttg tagcagtaga      960

agaagctcca tttcatcaca tgaaagtttc agcatcttgg actctggtat ttatcgtatc     1020

attagtagta gaagaggcag tcagtcagat gaagactctt gctcccttca cagccaaacc     1080

ctctcagaag atgagagatt taaagaattc acctcacagc aggaagagga cctgccagat     1140

cagtgttgtg gctcacacgg aaatgaagac aatgtttctc atgctccagt gatgtttgag     1200

acagataaga atgaaacttt tctcccgttc ggcattccat taccatttcg ttctccatct     1260

cctcttgtgt ctcttcaggc tgtcaaagaa agtgtttcta gctttgtgcg taaaactact     1320

gagaagattg gcacccttca cacgagccct gatctgaaag tgagaccaga gctcaggggt     1380

gatgagcaat catgtgaaga ggatgtgagt tcagatacct gcccaaagga ggaagacact     1440

gaggaggaaa aagaggtaac tagtccacct ccagaagaag acaggttcca ggagcttaaa     1500

gtagcaacag cagaagcaat gaccaagcta caggaccctc tggttttatt tgaatccgag     1560

tctctgagaa tggttttaca ggagtggctt tcacatttag aaaaaacatt tgccatgaag     1620

gacttttcag gtgtttcaga tactgacaac tcatccatga aattgaacca ggatgtgcta     1680

ttagttaatg aatcaaaaaa gggaatatta gatgaagata atgaaaaaga aaaaagggac     1740

tctttaggca atgaagaatc tgttgataaa acagcatgtg aatgtgtaag gagtccaagg     1800

gagtctttgg atgacctgtt tcaaatatgt tctccatgcg ccattgcaag tggtcttcgg     1860

aacgacctgg ctgaattgac aacattatgt ttggagttga atgtattgaa ttctaagatc     1920

aaaagcacca gtggacatgt ggaccacact ttgcaacagt actctcctga aattctggct     1980

tgccagttcc tgaagaagta cttttttctc ctgaacttga aaagagcgaa ggagagtatc     2040

aagcttagtt acagtaatag cccttctgtt tgggatactt ttattgaagg attgaaagaa     2100

atggcaagtt ccaatcctgt gtatatggag atggaaaaag gagatctacc aacaaggtta     2160

aagttactag atgacgaggt tccttttgat agtccgttgt tggttgttta tgctacccgg     2220

ttgtatgaaa agtttgggga gtctgctctt cgatccttaa tcaagttctt tccatccatt     2280

ttgccatcgg atatcataca actttgtcat catcatcctg ctgagttttt ggcctattta     2340

gacagtctgg tgaaatcaag gcctgaagat cagcggtcat cttttcttga gtcccttctg     2400

caaccagagt ctttaaggtt ggattggctg cttttggcag tgtcccttga tgctccacca     2460

agcaccagca caatggatga tgaaggttat cccaggcctc attcacactt gctttcctgg     2520

ggttacagtc agctgatcct tcatctaatt aaacttcctg cagattttat aaccaaagag     2580

aaaatgacag acatctgcag gtcttgtggt ttctggcctg gatatctaat tctctgtttg     2640

gagctggaga gaagaagaga ggccttcacc aatattgtgt atctgaatga tatgagcctg     2700

atggaagggg acaatggttg gatcccagag accgtggagg aatggaagct tctccttcat     2760

ctcatacaga gcaagagcac gaggccagcc ccccaggagt cactaaatgg gagcctcagt     2820

gatgggcctt cccccatcaa tgtggagaat gtggcacttc tgttagctaa ggccatgggc     2880

ccagatcggg cttggtcact gctacaggaa tgtggtctgg cccttgagtt gtcagagaag     2940

tttaccagaa cctgcgatat cctgaggatt gctgagaaaa ggcagagggc cttgatacaa     3000

agcatgcttg aaaaatgcga tcggtttctc tggtcccagc aggcctag                  3048


<210>  38
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Phe Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Arg Ile Ser Phe Asp Glu Phe Ile Lys Ile Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Asp Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asn Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Asn Lys Ile Gly Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Val Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Arg Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Glu Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Gly Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Ile Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Glu Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Glu Thr 
        515                 520                 525             


Leu Arg Glu Ala Lys Lys Ser Ser Ser Ile Ser Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asn Asp 
                565                 570                 575     


Asp Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         


<210>  39
<211>  627
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Arg Gly Ser Val Ser Asp Glu Glu Met Met Glu Leu Arg Glu 
1               5                   10                  15      


Ala Phe Ala Lys Val Asp Thr Asp Gly Asn Gly Tyr Ile Ser Cys Asn 
            20                  25                  30          


Glu Leu Asn Asp Leu Phe Lys Ala Ala Cys Leu Pro Leu Pro Gly Tyr 
        35                  40                  45              


Arg Val Arg Glu Ile Thr Glu Asn Leu Met Ala Thr Gly Asp Leu Asp 
    50                  55                  60                  


Gln Asp Gly Lys Ile Ser Phe Asp Glu Phe Ile Lys Val Phe His Gly 
65                  70                  75                  80  


Leu Lys Ser Thr Glu Val Ala Lys Thr Phe Arg Lys Ala Ile Asn Lys 
                85                  90                  95      


Lys Glu Gly Ile Cys Ala Ile Gly Gly Thr Ser Glu Gln Ser Ser Val 
            100                 105                 110         


Gly Thr Gln His Ser Tyr Ser Glu Glu Glu Lys Tyr Ala Phe Val Asn 
        115                 120                 125             


Trp Ile Asn Lys Ala Leu Glu Asn Asp Pro Asp Cys Arg His Val Ile 
    130                 135                 140                 


Pro Met Asn Pro Asn Thr Asp Asp Leu Phe Asn Ala Val Gly Asp Gly 
145                 150                 155                 160 


Ile Val Leu Cys Lys Met Ile Asn Leu Ser Val Pro Asp Thr Ile Asp 
                165                 170                 175     


Glu Arg Thr Ile Asn Lys Lys Lys Leu Thr Pro Phe Thr Ile Gln Glu 
            180                 185                 190         


Asn Leu Asn Leu Ala Leu Asn Ser Ala Ser Ala Ile Gly Cys His Val 
        195                 200                 205             


Val Asn Ile Gly Ala Glu Asp Leu Lys Glu Gly Lys Pro Tyr Leu Val 
    210                 215                 220                 


Leu Gly Leu Leu Trp Gln Val Ile Lys Ile Gly Leu Phe Ala Asp Ile 
225                 230                 235                 240 


Glu Leu Ser Arg Asn Glu Ala Leu Ile Ala Leu Leu Arg Glu Gly Glu 
                245                 250                 255     


Ser Leu Glu Asp Leu Met Lys Leu Ser Pro Glu Glu Leu Leu Leu Arg 
            260                 265                 270         


Trp Ala Asn Tyr His Leu Glu Asn Ala Gly Cys Thr Lys Ile Thr Asn 
        275                 280                 285             


Phe Ser Thr Asp Ile Lys Asp Ser Lys Ala Tyr Tyr His Leu Leu Glu 
    290                 295                 300                 


Gln Val Ala Pro Lys Gly Asp Glu Glu Gly Ile Pro Ala Val Val Ile 
305                 310                 315                 320 


Asp Met Ser Gly Leu Arg Glu Lys Asp Asp Ile Gln Arg Ala Glu Cys 
                325                 330                 335     


Met Leu Gln Gln Ala Glu Arg Leu Gly Cys Arg Gln Phe Val Thr Ala 
            340                 345                 350         


Thr Asp Val Val Arg Gly Asn Pro Lys Leu Asn Leu Ala Phe Ile Ala 
        355                 360                 365             


Asn Leu Phe Asn Lys Tyr Pro Ala Leu His Lys Pro Glu Asn Gln Asp 
    370                 375                 380                 


Ile Asp Trp Gly Ala Leu Glu Gly Glu Thr Arg Glu Glu Arg Thr Phe 
385                 390                 395                 400 


Arg Asn Trp Met Asn Ser Leu Gly Val Asn Pro Arg Val Asn His Leu 
                405                 410                 415     


Tyr Ser Asp Leu Ser Asp Ala Leu Val Ile Phe Gln Leu Tyr Glu Lys 
            420                 425                 430         


Ile Lys Val Pro Val Asp Trp Asn Arg Val Asn Lys Pro Pro Tyr Pro 
        435                 440                 445             


Lys Leu Gly Gly Asn Met Lys Lys Leu Glu Asn Cys Asn Tyr Ala Val 
    450                 455                 460                 


Asp Leu Gly Lys Asn Gln Ala Lys Phe Ser Leu Val Gly Ile Ala Gly 
465                 470                 475                 480 


Gln Asp Leu Asn Glu Gly Asn Arg Thr Leu Thr Leu Ala Leu Val Trp 
                485                 490                 495     


Gln Leu Met Arg Arg Tyr Thr Leu Asn Ile Leu Glu Asp Ile Gly Gly 
            500                 505                 510         


Gly Gln Lys Val Asn Asp Asp Ile Ile Val Asn Trp Val Asn Thr Thr 
        515                 520                 525             


Leu Lys Glu Ala Gln Lys Ser Ser Ser Ile Ala Ser Phe Lys Asp Pro 
    530                 535                 540                 


Lys Ile Ser Thr Ser Leu Pro Val Leu Asp Leu Ile Asp Ala Ile Gln 
545                 550                 555                 560 


Pro Gly Ser Ile Asn Tyr Asp Leu Leu Lys Thr Glu Asn Leu Asp Asp 
                565                 570                 575     


Glu Glu Lys Leu Asn Asn Ala Lys Tyr Ala Ile Ser Met Ala Arg Lys 
            580                 585                 590         


Ile Gly Ala Arg Val Tyr Ala Leu Pro Glu Asp Leu Val Glu Val Asn 
        595                 600                 605             


Pro Lys Met Val Met Thr Val Phe Ala Cys Leu Met Gly Lys Gly Met 
    610                 615                 620                 


Lys Arg Val 
625         


<210>  40
<211>  1884
<212>  DNA
<213>  Homo sapiens

<400>  40
atggccagag gatcagtgtc cgatgaggaa atgatggagc tcagagaagc ttttgccaaa       60

gttgatactg atggcaatgg atacatcagc ttcaatgagt tgaatgactt gttcaaggct      120

gcttgcttgc ctttgcctgg gtatagagta cgagaaatta cagaaaacct gatggctaca      180

ggtgatctgg accaagatgg aaggatcagc tttgatgagt ttatcaagat tttccatggc      240

ctaaaaagca cagatgttgc caagaccttt agaaaagcaa tcaataagaa ggaagggatt      300

tgtgcaatcg gtggtacttc agagcagtct agcgttggca cccaacactc ctattcagag      360

gaagaaaagt atgcctttgt caactggata aacaaagccc tggaaaatga tcctgattgt      420

cggcatgtca tcccaatgaa cccaaacacg aatgatctct ttaatgctgt tggagatggc      480

attgtccttt gtaaaatgat caacctgtca gtgccagaca caattgatga aagaacaatc      540

aacaaaaaga agctaacccc tttcaccatt caggaaaatc tgaacttggc tctgaactct      600

gcctcagcca tcgggtgcca tgtggtcaac ataggggctg aggacctgaa ggaggggaag      660

ccttatctgg tcctgggact tctgtggcaa gtcatcaaga ttgggttgtt tgctgacatt      720

gaactcagca gaaatgaagc tctgattgct cttttgagag aaggtgagag cctggaggat      780

ttgatgaaac tctcccctga agagctcttg ctgaggtggg ctaattacca cctggaaaat      840

gcaggctgca acaaaattgg caacttcagt actgacatca aggactcaaa agcttattac      900

cacctgcttg agcaggtggc tccaaaagga gatgaagaag gtgttcctgc tgttgttatt      960

gacatgtcag gactgcggga gaaggatgac atccagaggg cagaatgcat gctgcagcag     1020

gcggagaggc tgggctgccg gcagtttgtc acagccacag atgttgtccg agggaacccc     1080

aagttgaact tggcttttat tgccaacctc tttaacagat accctgccct gcacaaacca     1140

gagaaccagg acattgactg gggggctctt gaaggtgaga cgagagaaga gcggacattt     1200

aggaactgga tgaactccct gggtgttaac cctcgagtca atcatttgta cagtgactta     1260

tcagatgccc tggtcatctt ccagctctat gaaaagatca aagttcctgt tgactggaac     1320

agagtaaaca aaccgccata ccccaaactg ggaggcaata tgaagaagct tgagaattgt     1380

aactacgcgg tagaattggg gaagaatcaa gcgaagttct ccctggttgg catcggtgga     1440

caagatctca atgaaggaaa ccgcactctc acactggcct tgatttggca gctaatgaga     1500

aggtatacac tgaatatcct cgaagaaatt ggtggtggcc agaaggtcaa tgatgacatt     1560

attgtcaact gggtgaatga aacattgagg gaagcaaaga aaagttcatc catctctagt     1620

ttcaaggacc cgaagattag tacaagtctg cctgttctgg acctcatcga tgccatccaa     1680

ccaggttcca ttaactatga ccttctgaag acagaaaatc tgaatgatga tgagaaactc     1740

aacaatgcaa aatatgccat ctctatggcc cgaaaaattg gagcaagagt gtatgccctg     1800

ccagaagacc tggttgaagt gaaccccaaa atggtcatga ccgtgtttgc ctgcctcatg     1860

gggaaaggaa tgaagagggt gtga                                            1884


<210>  41
<211>  906
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gln Ala Ala Val Ala Val Ser Val Pro Phe Leu Leu Leu Cys Val 
1               5                   10                  15      


Leu Gly Thr Cys Pro Pro Ala Arg Cys Gly Gln Ala Gly Asp Ala Ser 
            20                  25                  30          


Leu Met Glu Leu Glu Lys Arg Lys Glu Asn Arg Phe Val Glu Arg Gln 
        35                  40                  45              


Ser Ile Val Pro Leu Arg Leu Ile Tyr Arg Ser Gly Gly Glu Asp Glu 
    50                  55                  60                  


Ser Arg His Asp Ala Leu Asp Thr Arg Val Arg Gly Asp Leu Gly Gly 
65                  70                  75                  80  


Pro Gln Leu Thr His Val Asp Gln Ala Ser Phe Gln Val Asp Ala Phe 
                85                  90                  95      


Gly Thr Ser Phe Ile Leu Asp Val Val Leu Asn His Asp Leu Leu Ser 
            100                 105                 110         


Ser Glu Tyr Ile Glu Arg His Ile Glu His Gly Gly Lys Thr Val Glu 
        115                 120                 125             


Val Lys Gly Gly Glu His Cys Tyr Tyr Gln Gly His Ile Arg Gly Asn 
    130                 135                 140                 


Pro Asp Ser Phe Val Ala Leu Ser Thr Cys His Gly Leu His Gly Met 
145                 150                 155                 160 


Phe Tyr Asp Gly Asn His Thr Tyr Leu Ile Glu Pro Glu Glu Asn Asp 
                165                 170                 175     


Thr Thr Gln Glu Asp Phe His Phe His Ser Val Tyr Lys Ser Arg Leu 
            180                 185                 190         


Phe Glu Phe Ser Leu Asp Asp Leu Pro Ser Glu Phe Gln Gln Val Asn 
        195                 200                 205             


Ile Thr Pro Ser Lys Phe Ile Leu Lys Pro Arg Pro Lys Arg Ser Lys 
    210                 215                 220                 


Arg Gln Leu Arg Arg Tyr Pro Arg Asn Val Glu Glu Glu Thr Lys Tyr 
225                 230                 235                 240 


Ile Glu Leu Met Ile Val Asn Asp His Leu Met Phe Lys Lys His Arg 
                245                 250                 255     


Leu Ser Val Val His Thr Asn Thr Tyr Ala Lys Ser Val Val Asn Met 
            260                 265                 270         


Ala Asp Leu Ile Tyr Lys Asp Gln Leu Lys Thr Arg Ile Val Leu Val 
        275                 280                 285             


Ala Met Glu Thr Trp Ala Thr Asp Asn Lys Phe Ala Ile Ser Glu Asn 
    290                 295                 300                 


Pro Leu Ile Thr Leu Arg Glu Phe Met Lys Tyr Arg Arg Asp Phe Ile 
305                 310                 315                 320 


Lys Glu Lys Ser Asp Ala Val His Leu Phe Ser Gly Ser Gln Phe Glu 
                325                 330                 335     


Ser Ser Arg Ser Gly Ala Ala Tyr Ile Gly Gly Ile Cys Ser Leu Leu 
            340                 345                 350         


Lys Gly Gly Gly Val Asn Glu Phe Gly Lys Thr Asp Leu Met Ala Val 
        355                 360                 365             


Thr Leu Ala Gln Ser Leu Ala His Asn Ile Gly Ile Ile Ser Asp Lys 
    370                 375                 380                 


Arg Lys Leu Ala Ser Gly Glu Cys Lys Cys Glu Asp Thr Trp Ser Gly 
385                 390                 395                 400 


Cys Ile Met Gly Asp Thr Gly Tyr Tyr Leu Pro Lys Lys Phe Thr Gln 
                405                 410                 415     


Cys Asn Ile Glu Glu Tyr His Asp Phe Leu Asn Ser Gly Gly Gly Ala 
            420                 425                 430         


Cys Leu Phe Asn Lys Pro Ser Lys Leu Leu Asp Pro Pro Glu Cys Gly 
        435                 440                 445             


Asn Gly Phe Ile Glu Thr Gly Glu Glu Cys Asp Cys Gly Thr Pro Ala 
    450                 455                 460                 


Glu Cys Val Leu Glu Gly Ala Glu Cys Cys Lys Lys Cys Thr Leu Thr 
465                 470                 475                 480 


Gln Asp Ser Gln Cys Ser Asp Gly Leu Cys Cys Lys Lys Cys Lys Phe 
                485                 490                 495     


Gln Pro Met Gly Thr Val Cys Arg Glu Ala Val Asn Asp Cys Asp Ile 
            500                 505                 510         


Arg Glu Thr Cys Ser Gly Asn Ser Ser Gln Cys Ala Pro Asn Ile His 
        515                 520                 525             


Lys Met Asp Gly Tyr Ser Cys Asp Gly Val Gln Gly Ile Cys Phe Gly 
    530                 535                 540                 


Gly Arg Cys Lys Thr Arg Asp Arg Gln Cys Lys Tyr Ile Trp Gly Gln 
545                 550                 555                 560 


Lys Val Thr Ala Ser Asp Lys Tyr Cys Tyr Glu Lys Leu Asn Ile Glu 
                565                 570                 575     


Gly Thr Glu Lys Gly Asn Cys Gly Lys Asp Lys Asp Thr Trp Ile Gln 
            580                 585                 590         


Cys Asn Lys Arg Asp Val Leu Cys Gly Tyr Leu Leu Cys Thr Asn Ile 
        595                 600                 605             


Gly Asn Ile Pro Arg Leu Gly Glu Leu Asp Gly Glu Ile Thr Ser Thr 
    610                 615                 620                 


Leu Val Val Gln Gln Gly Arg Thr Leu Asn Cys Ser Gly Gly His Val 
625                 630                 635                 640 


Lys Leu Glu Glu Asp Val Asp Leu Gly Tyr Val Glu Asp Gly Thr Pro 
                645                 650                 655     


Cys Gly Pro Gln Met Met Cys Leu Glu His Arg Cys Leu Pro Val Ala 
            660                 665                 670         


Ser Phe Asn Phe Ser Thr Cys Leu Ser Ser Lys Glu Gly Thr Ile Cys 
        675                 680                 685             


Ser Gly Asn Gly Val Cys Ser Asn Glu Leu Lys Cys Val Cys Asn Arg 
    690                 695                 700                 


His Trp Ile Gly Ser Asp Cys Asn Thr Tyr Phe Pro His Asn Asp Asp 
705                 710                 715                 720 


Ala Lys Thr Gly Ile Thr Leu Ser Gly Asn Gly Val Ala Gly Thr Asn 
                725                 730                 735     


Ile Ile Ile Gly Ile Ile Ala Gly Thr Ile Leu Val Leu Ala Leu Ile 
            740                 745                 750         


Leu Gly Ile Thr Ala Trp Gly Tyr Lys Asn Tyr Arg Glu Gln Arg Gln 
        755                 760                 765             


Leu Pro Gln Gly Asp Tyr Val Lys Lys Pro Gly Asp Gly Asp Ser Phe 
    770                 775                 780                 


Tyr Ser Asp Ile Pro Pro Gly Val Ser Thr Asn Ser Ala Ser Ser Ser 
785                 790                 795                 800 


Lys Lys Arg Ser Asn Gly Leu Ser His Ser Trp Ser Glu Arg Ile Pro 
                805                 810                 815     


Asp Thr Lys His Ile Ser Asp Ile Cys Glu Asn Gly Arg Pro Arg Ser 
            820                 825                 830         


Asn Ser Trp Gln Gly Asn Leu Gly Gly Asn Lys Lys Lys Ile Arg Gly 
        835                 840                 845             


Lys Arg Phe Arg Pro Arg Ser Asn Ser Thr Glu Thr Leu Ser Pro Ala 
    850                 855                 860                 


Lys Ser Pro Ser Ser Ser Thr Gly Ser Ile Ala Ser Ser Arg Lys Tyr 
865                 870                 875                 880 


Pro Tyr Pro Met Pro Pro Leu Pro Asp Glu Asp Lys Lys Val Asn Arg 
                885                 890                 895     


Gln Ser Ala Arg Leu Trp Glu Thr Ser Ile 
            900                 905     


<210>  42
<211>  2721
<212>  DNA
<213>  Homo sapiens

<400>  42
atgcaggcgg cagtggctgt gtccgtgccc ttcttgctgc tctgtgtcct ggggacctgc       60

cctccggcgc gctgcggcca ggcaggagac gcctcattga tggagctaga gaagaggaag      120

gaaaaccgct tcgtggagcg ccagagcatc gtgccactgc gcctcatcta ccgctcgggc      180

ggcgaagacg aaagtcggca cgacgcgctc gacacgcggg tgcggggcga cctcggtggc      240

ccgcagttga ctcatgttga ccaagcaagc ttccaggttg atgcctttgg aacgtcattc      300

attctcgatg tcgtgctaaa tcatgatttg ctgtcctctg aatacataga gagacacatt      360

gaacatggag gcaagactgt ggaagttaaa ggaggagagc actgttacta ccagggccat      420

atccgaggaa accctgactc atttgttgca ttgtcaacat gccacggact tcatgggatg      480

ttctatgacg ggaaccacac atatctcatt gagccagaag aaaatgacac tactcaagag      540

gatttccatt ttcattcagt ttacaaatcc agactgtttg aattttcctt ggatgatctt      600

ccatctgaat ttcagcaagt aaacattact ccatcaaaat ttattttgaa gccaagacca      660

aaaaggagta aacggcagct tcgtcgatat cctcgtaatg tagaagaaga aaccaaatac      720

attgaactga tgattgtgaa tgatcacctt atgtttaaaa aacatcggct ttccgttgta      780

cataccaata cctatgcgaa atctgtggtg aacatggcag atttaatata taaagaccaa      840

cttaagacca ggatagtatt ggttgctatg gaaacctggg cgactgacaa caagtttgcc      900

atatctgaaa atccattgat caccctacgt gagtttatga aatacaggag ggattttatc      960

aaagagaaaa gtgatgcagt tcaccttttt tcgggaagtc aatttgagag tagccggagc     1020

ggggcagctt atattggtgg gatttgctcg ttgctgaaag gaggaggcgt gaatgaattt     1080

gggaaaactg atttaatggc tgttacactt gcccagtcat tagcccataa tattggtatt     1140

atctcagaca aaagaaagtt agcaagtggt gaatgtaaat gcgaggacac gtggtccggg     1200

tgcataatgg gagacactgg ctattatctt cctaaaaagt tcacccagtg taatattgaa     1260

gagtatcatg acttcctgaa tagtggaggt ggtgcctgcc ttttcaacaa accttctaag     1320

cttcttgatc ctcctgagtg tggcaatggc ttcattgaaa ctggagagga gtgtgattgt     1380

ggaaccccgg ccgaatgtgt ccttgaagga gcagagtgtt gtaagaaatg caccttgact     1440

caagactctc aatgcagtga cggtctttgc tgtaaaaagt gcaagtttca gcctatgggc     1500

actgtgtgcc gagaagcagt aaatgattgt gatattcgtg aaacgtgctc aggaaattca     1560

agccagtgtg cccctaatat tcataaaatg gatggatatt catgtgatgg tgttcaggga     1620

atttgctttg gaggaagatg caaaaccaga gatagacaat gcaaatacat ttgggggcaa     1680

aaggtgacag catcagacaa atattgctat gagaaactga atattgaagg gacggagaag     1740

ggtaactgtg ggaaagacaa agacacatgg atacagtgca acaaacggga tgtgctttgt     1800

ggttaccttt tgtgtaccaa tattggcaat atcccaaggc ttggagaact cgatggtgaa     1860

atcacatcta ctttagttgt gcagcaagga agaacattaa actgcagtgg tgggcatgtt     1920

aagcttgaag aagatgtaga tcttggctat gtggaagatg ggacaccttg tggtccccaa     1980

atgatgtgct tagaacacag gtgtcttcct gtggcttctt tcaactttag tacttgcttg     2040

agcagtaaag aaggcactat ttgctcagga aatggagttt gcagtaatga gctgaagtgt     2100

gtgtgtaaca gacactggat aggttctgat tgcaacactt acttccctca caatgatgat     2160

gcaaagactg gtatcactct gtctggcaat ggtgttgctg gcaccaatat cataataggc     2220

ataattgctg gcaccatttt agtgctggcc ctcatattag gaataactgc gtggggttat     2280

aaaaactatc gagaacagag acagttaccc cagggagatt atgtaaaaaa gcctggagat     2340

ggtgactctt tttatagcga cattcctccc ggagtcagca caaactcagc atctagttct     2400

aagaagaggt caaatgggct ctctcattct tggagtgaaa ggattccaga cacaaaacat     2460

atttcagaca tctgtgaaaa tgggcgacct cgaagtaact cttggcaagg taacctggga     2520

ggcaacaaaa agaaaatcag aggcaaaaga tttagacctc ggtctaattc aactgagact     2580

ttatctcctg ccaagtctcc ttcttcatca actgggtcta ttgcctccag cagaaaatac     2640

ccttacccaa tgcctccact tcctgatgag gacaagaaag tgaaccgaca aagtgccagg     2700

ctatgggaga catccattta a                                               2721


<210>  43
<211>  2700
<212>  DNA
<213>  Homo sapiens

<400>  43
atgcaggcgg cagtggctgt gtccgtgccc ttcttgctgc tctgtgtcct ggggacctgc       60

cctccggcgc gctgcggcca ggcaggagac gcctcattga tggagctaga gaagaggaag      120

gaaaaccgct tcgtggagcg ccagagcatc gtgccactgc gcctcatcta ccgctcgggc      180

ggcgaagacg aaagtcggca cgacgcgctc gacacgcggg tgcggggcga cctcggtggc      240

ccgcagttga ctcatgttga ccaagcaagc ttccaggttg atgcctttgg aacgtcattc      300

attctcgatg tcgtgctaaa tcatgatttg ctgtcctctg aatacataga gagacacatt      360

gaacatggag gcaagactgt ggaagttaaa ggaggagagc actgttacta ccagggccat      420

atccgaggaa accctgactc atttgttgca ttgtcaacat gccacggact tcatgggatg      480

ttctatgacg ggaaccacac atatctcatt gagccagaag aaaatgacac tactcaagag      540

gatttccatt ttcattcagt ttacaaatcc agactgtttg aattttcctt ggatgatctt      600

ccatctgaat ttcagcaagt aaacattact ccatcaaaat ttattttgaa gccaagacca      660

aaaaggagta aacggcagct tcgtcgatat cctcgtaatg tagaagaaga aaccaaatac      720

attgaactga tgattgtgaa tgatcacctt atgtttaaaa aacatcggct ttccgttgta      780

cataccaata cctatgcgaa atctgtggtg aacatggcag atttaatata taaagaccaa      840

cttaagacca ggatagtatt ggttgctatg gaaacctggg cgactgacaa caagtttgcc      900

atatctgaaa atccattgat caccctacgt gagtttatga aatacaggag ggattttatc      960

aaagagaaaa gtgatgcagt tcaccttttt tcgggaagtc aatttgagag tagccggagc     1020

ggggcagctt atattggtgg gatttgctcg ttgctgaaag gaggaggcgt gaatgaattt     1080

gggaaaactg atttaatggc tgttacactt gcccagtcat tagcccataa tattggtatt     1140

atctcagaca aaagaaagtt agcaagtggt gaatgtaaat gcgaggacac gtggtccggg     1200

tgcataatgg gagacactgg ctattatctt cctaaaaagt tcacccagtg taatattgaa     1260

gagtatcatg acttcctgaa tagtggaggt ggtgcctgcc ttttcaacaa accttctaag     1320

cttcttgatc ctcctgagtg tggcaatggc ttcattgaaa ctggagagga gtgtgattgt     1380

ggaaccccgg ccgaatgtgt ccttgaagga gcagagtgtt gtaagaaatg caccttgact     1440

caagactctc aatgcagtga cggtctttgc tgtaaaaagt gcaagtttca gcctatgggc     1500

actgtgtgcc gagaagcagt aaatgattgt gatattcgtg aaacgtgctc aggaaattca     1560

agccagtgtg cccctaatat tcataaaatg gatggatatt catgtgatgg tgttcaggga     1620

atttgctttg gaggaagatg caaaaccaga gatagacaat gcaaatacat ttgggggcaa     1680

aaggtgacag catcagacaa atattgctat gagaaactga atattgaagg gacggagaag     1740

ggtaactgtg ggaaagacaa agacacatgg atacagtgca acaaacggga tgtgctttgt     1800

ggttaccttt tgtgtaccaa tattggcaat atcccaaggc ttggagaact cgatggtgaa     1860

atcacatcta ctttagttgt gcagcaagga agaacattaa actgcagtgg tgggcatgtt     1920

aagcttgaag aagatgtaga tcttggctat gtggaagatg ggacaccttg tggtccccaa     1980

atgatgtgct tagaacacag gtgtcttcct gtggcttctt tcaactttag tacttgcttg     2040

agcagtaaag aaggcactat ttgctcagga aatggagttt gcagtaatga gctgaagtgt     2100

gtgtgtaaca gacactggat aggttctgat tgcaacactt acttccctca caatgatgat     2160

gcaaagactg gtatcactct gtctggcaat ggtgttgctg gcaccaatat cataataggc     2220

ataattgctg gcaccatttt agtgctggcc ctcatattag gaataactgc gtggggttat     2280

aaaaactatc gagaacagag gtcaaatggg ctctctcatt cttggagtga aaggattcca     2340

gacacaaaac atatttcaga catctgtgaa aatgggcgac ctcgaagtaa ctcttggcaa     2400

ggtaacctgg gaggcaacaa aaagaaaatc agaggcaaaa gatttagacc tcggtctaat     2460

tcaactgagt atttaaaccc atggttcaaa agagactata atgtagctaa gtgggtagaa     2520

gatgtgaata aaaacactga aggaccatac tttaggactt tatctcctgc caagtctcct     2580

tcttcatcaa ctgggtctat tgcctccagc agaaaatacc cttacccaat gcctccactt     2640

cctgatgagg acaagaaagt gaaccgacaa agtgccaggc tatgggagac atccatttaa     2700


<210>  44
<211>  2613
<212>  DNA
<213>  Homo sapiens

<400>  44
atgcaggcgg cagtggctgt gtccgtgccc ttcttgctgc tctgtgtcct ggggacctgc       60

cctccggcgc gctgcggcca ggcaggagac gcctcattga tggagctaga gaagaggaag      120

gaaaaccgct tcgtggagcg ccagagcatc gtgccactgc gcctcatcta ccgctcgggc      180

ggcgaagacg aaagtcggca cgacgcgctc gacacgcggg tgcggggcga cctcggtggc      240

ccgcagttga ctcatgttga ccaagcaagc ttccaggttg atgcctttgg aacgtcattc      300

attctcgatg tcgtgctaaa tcatgatttg ctgtcctctg aatacataga gagacacatt      360

gaacatggag gcaagactgt ggaagttaaa ggaggagagc actgttacta ccagggccat      420

atccgaggaa accctgactc atttgttgca ttgtcaacat gccacggact tcatgggatg      480

ttctatgacg ggaaccacac atatctcatt gagccagaag aaaatgacac tactcaagag      540

gatttccatt ttcattcagt ttacaaatcc agactgtttg aattttcctt ggatgatctt      600

ccatctgaat ttcagcaagt aaacattact ccatcaaaat ttattttgaa gccaagacca      660

aaaaggagta aacggcagct tcgtcgatat cctcgtaatg tagaagaaga aaccaaatac      720

attgaactga tgattgtgaa tgatcacctt atgtttaaaa aacatcggct ttccgttgta      780

cataccaata cctatgcgaa atctgtggtg aacatggcag atttaatata taaagaccaa      840

cttaagacca ggatagtatt ggttgctatg gaaacctggg cgactgacaa caagtttgcc      900

atatctgaaa atccattgat caccctacgt gagtttatga aatacaggag ggattttatc      960

aaagagaaaa gtgatgcagt tcaccttttt tcgggaagtc aatttgagag tagccggagc     1020

ggggcagctt atattggtgg gatttgctcg ttgctgaaag gaggaggcgt gaatgaattt     1080

gggaaaactg atttaatggc tgttacactt gcccagtcat tagcccataa tattggtatt     1140

atctcagaca aaagaaagtt agcaagtggt gaatgtaaat gcgaggacac gtggtccggg     1200

tgcataatgg gagacactgg ctattatctt cctaaaaagt tcacccagtg taatattgaa     1260

gagtatcatg acttcctgaa tagtggaggt ggtgcctgcc ttttcaacaa accttctaag     1320

cttcttgatc ctcctgagtg tggcaatggc ttcattgaaa ctggagagga gtgtgattgt     1380

ggaaccccgg ccgaatgtgt ccttgaagga gcagagtgtt gtaagaaatg caccttgact     1440

caagactctc aatgcagtga cggtctttgc tgtaaaaagt gcaagtttca gcctatgggc     1500

actgtgtgcc gagaagcagt aaatgattgt gatattcgtg aaacgtgctc aggaaattca     1560

agccagtgtg cccctaatat tcataaaatg gatggatatt catgtgatgg tgttcaggga     1620

atttgctttg gaggaagatg caaaaccaga gatagacaat gcaaatacat ttgggggcaa     1680

aaggtgacag catcagacaa atattgctat gagaaactga atattgaagg gacggagaag     1740

ggtaactgtg ggaaagacaa agacacatgg atacagtgca acaaacggga tgtgctttgt     1800

ggttaccttt tgtgtaccaa tattggcaat atcccaaggc ttggagaact cgatggtgaa     1860

atcacatcta ctttagttgt gcagcaagga agaacattaa actgcagtgg tgggcatgtt     1920

aagcttgaag aagatgtaga tcttggctat gtggaagatg ggacaccttg tggtccccaa     1980

atgatgtgct tagaacacag gtgtcttcct gtggcttctt tcaactttag tacttgcttg     2040

agcagtaaag aaggcactat ttgctcagga aatggagttt gcagtaatga gctgaagtgt     2100

gtgtgtaaca gacactggat aggttctgat tgcaacactt acttccctca caatgatgat     2160

gcaaagactg gtatcactct gtctggcaat ggtgttgctg gcaccaatat cataataggc     2220

ataattgctg gcaccatttt agtgctggcc ctcatattag gaataactgc gtggggttat     2280

aaaaactatc gagaacagag gtcaaatggg ctctctcatt cttggagtga aaggattcca     2340

gacacaaaac atatttcaga catctgtgaa aatgggcgac ctcgaagtaa ctcttggcaa     2400

ggtaacctgg gaggcaacaa aaagaaaatc agaggcaaaa gatttagacc tcggtctaat     2460

tcaactgaga ctttatctcc tgccaagtct ccttcttcat caactgggtc tattgcctcc     2520

agcagaaaat acccttaccc aatgcctcca cttcctgatg aggacaagaa agtgaaccga     2580

caaagtgcca ggctatggga gacatccatt taa                                  2613


<210>  45
<211>  2580
<212>  DNA
<213>  Homo sapiens

<400>  45
atgcaggcgg cagtggctgt gtccgtgccc ttcttgctgc tctgtgtcct ggggacctgc       60

cctccggcgc gctgcggcca ggcaggagac gcctcattga tggagctaga gaagaggaag      120

gaaaaccgct tcgtggagcg ccagagcatc gtgccactgc gcctcatcta ccgctcgggc      180

ggcgaagacg aaagtcggca cgacgcgctc gacacgcggg tgcggggcga cctcggtggc      240

ccgcagttga ctcatgttga ccaagcaagc ttccaggttg atgcctttgg aacgtcattc      300

attctcgatg tcgtgctaaa tcatgatttg ctgtcctctg aatacataga gagacacatt      360

gaacatggag gcaagactgt ggaagttaaa ggaggagagc actgttacta ccagggccat      420

atccgaggaa accctgactc atttgttgca ttgtcaacat gccacggact tcatgggatg      480

ttctatgacg ggaaccacac atatctcatt gagccagaag aaaatgacac tactcaagag      540

gatttccatt ttcattcagt ttacaaatcc agactgtttg aattttcctt ggatgatctt      600

ccatctgaat ttcagcaagt aaacattact ccatcaaaat ttattttgaa gccaagacca      660

aaaaggagta aacggcagct tcgtcgatat cctcgtaatg tagaagaaga aaccaaatac      720

attgaactga tgattgtgaa tgatcacctt atgtttaaaa aacatcggct ttccgttgta      780

cataccaata cctatgcgaa atctgtggtg aacatggcag atttaatata taaagaccaa      840

cttaagacca ggatagtatt ggttgctatg gaaacctggg cgactgacaa caagtttgcc      900

atatctgaaa atccattgat caccctacgt gagtttatga aatacaggag ggattttatc      960

aaagagaaaa gtgatgcagt tcaccttttt tcgggaagtc aatttgagag tagccggagc     1020

ggggcagctt atattggtgg gatttgctcg ttgctgaaag gaggaggcgt gaatgaattt     1080

gggaaaactg atttaatggc tgttacactt gcccagtcat tagcccataa tattggtatt     1140

atctcagaca aaagaaagtt agcaagtggt gaatgtaaat gcgaggacac gtggtccggg     1200

tgcataatgg gagacactgg ctattatctt cctaaaaagt tcacccagtg taatattgaa     1260

gagtatcatg acttcctgaa tagtggaggt ggtgcctgcc ttttcaacaa accttctaag     1320

cttcttgatc ctcctgagtg tggcaatggc ttcattgaaa ctggagagga gtgtgattgt     1380

ggaaccccgg ccgaatgtgt ccttgaagga gcagagtgtt gtaagaaatg caccttgact     1440

caagactctc aatgcagtga cggtctttgc tgtaaaaagt gcaagtttca gcctatgggc     1500

actgtgtgcc gagaagcagt aaatgattgt gatattcgtg aaacgtgctc aggaaattca     1560

agccagtgtg cccctaatat tcataaaatg gatggatatt catgtgatgg tgttcaggga     1620

atttgctttg gaggaagatg caaaaccaga gatagacaat gcaaatacat ttgggggcaa     1680

aaggtgacag catcagacaa atattgctat gagaaactga atattgaagg gacggagaag     1740

ggtaactgtg ggaaagacaa agacacatgg atacagtgca acaaacggga tgtgctttgt     1800

ggttaccttt tgtgtaccaa tattggcaat atcccaaggc ttggagaact cgatggtgaa     1860

atcacatcta ctttagttgt gcagcaagga agaacattaa actgcagtgg tgggcatgtt     1920

aagcttgaag aagatgtaga tcttggctat gtggaagatg ggacaccttg tggtccccaa     1980

atgatgtgct tagaacacag gtgtcttcct gtggcttctt tcaactttag tacttgcttg     2040

agcagtaaag aaggcactat ttgctcagga aatggagttt gcagtaatga gctgaagtgt     2100

gtgtgtaaca gacactggat aggttctgat tgcaacactt acttccctca caatgatgat     2160

gcaaagactg gtatcactct gtctggcaat ggtgttgctg gcaccaatat cataataggc     2220

ataattgctg gcaccatttt agtgctggcc ctcatattag gaataactgc gtggggttat     2280

aaaaactatc gagaacagag acagttaccc cagggagatt atgtaaaaaa gcctggagat     2340

ggtgactctt tttatagcga cattcctccc ggagtcagca caaactcagc atctagttct     2400

aagaagaggt caaatgggct ctctcattct tggagtgaaa ggattccaga cacaaaacat     2460

atttcagaca tctgtgaaaa tgggcgacct cgaagtaact cttggcaagg taacctggga     2520

ggcaacaaaa agaaaatcag aggcaaaaga tttagacctc ggtctaattc aactgagtaa     2580


<210>  46
<211>  1342
<212>  DNA
<213>  Homo sapiens

<400>  46
cattcgggga cgctctcagc gctctgctca cgacccagct tccttcaaaa tatctgctgt       60

tcatgaaatc ctgtgcaagc tcagcttgga gggtgatcac tctacatccc caagtgcatt      120

tgggtcagtc aaagcctaca ccaaatttga tgctgagcag gatgctttga acattgaaat      180

ggccatcaag accaaaggtg tggatgagat caccactgtc aacattttga ctaaccacag      240

caatgcacag agacaggata ttgccttcac ctaccagaga aggaccaaaa aggaacttgt      300

atcagcactt aagtcagcct tatctggcca cctagatagt ggctttgggc ctattaaaga      360

cacctgctca gtatgatgct tctgagctaa aatcttccat gaaggggctg ggaaccaaca      420

aggactccct cattgagatc atctgctcaa gaaccaacca agagctgcag gaaattaaca      480

gagtctacaa ggaaatgtac aagactgatc tggagaagga cattatttcg gacacatctg      540

gtgacttctg caagctgatg gttgccctgg caaagggtag aagagcagag gatggctctg      600

tcattgatta tgaactgatt gaccaagatg cccgggatct ctatgacgct ggggtgaaga      660

ggaaaggaac tgaagttccc aagtggatca gcgtcatgac cgagcggagc atgtcccact      720

tccagaaagt atttgatagg tacaagagct acagtcctta tgacatgttg gagagcatca      780

agaaagaggt taaaggagac ctggaaaatt ctttcctgaa cctggtccag tgtattcaga      840

acaagcccct gtatttcgct gaccggctgt acgactccat aatgggcatg gggactcaag      900

ataaggtcct gatcagaatc atggtctccc acaatgaagt ggacatgttg aaaattaggt      960

ctgaattcaa gagaaagtat agcaagtccc tgtactacta tatccagcaa gacactaagg     1020

gtgctgtacc tgtgtggtgg agatggctga agtccgacac agcacgagcg tccagaaatg     1080

gtgctcccca tgcttccagc taacaggtct agaaaacccg cttgtgacta gcagtccctg     1140

tggctgttcc tgtgaggatg acgttagcat tacccccaac ctcattttag ttgcctaagc     1200

attgcctggc tttcctgtct agtctctcct gtaagccaaa gaaatgaaca ttccaaggaa     1260

ttggaagtga agtctatgat gtaaacactt tgcctcctgt gtactgtgtc ataaacggat     1320

taataaactg aatttgtact tt                                              1342


<210>  47
<211>  758
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Ser Glu Val Leu Pro Ala Asp Ser Gly Val Asp Thr Leu Ala Val 
1               5                   10                  15      


Phe Met Ala Ser Ser Gly Thr Thr Asp Val Thr Asn Arg Asn Ser Pro 
            20                  25                  30          


Ala Thr Pro Pro Asn Thr Leu Asn Leu Arg Ser Ser His Asn Glu Leu 
        35                  40                  45              


Leu Asn Ala Glu Ile Lys His Thr Glu Thr Lys Asn Ser Thr Pro Pro 
    50                  55                  60                  


Lys Cys Arg Lys Lys Tyr Ala Leu Thr Asn Ile Gln Ala Ala Met Gly 
65                  70                  75                  80  


Leu Ser Asp Pro Ala Ala Gln Pro Leu Leu Gly Asn Gly Ser Ala Asn 
                85                  90                  95      


Ile Lys Leu Val Lys Asn Gly Glu Asn Gln Leu Arg Lys Ala Ala Glu 
            100                 105                 110         


Gln Gly Gln Gln Asp Pro Asn Lys Asn Leu Ser Pro Thr Ala Val Ile 
        115                 120                 125             


Asn Ile Thr Ser Glu Lys Leu Glu Gly Lys Glu Pro His Pro Gln Asp 
    130                 135                 140                 


Ser Ser Ser Cys Glu Ile Leu Pro Ser Gln Pro Arg Arg Thr Lys Ser 
145                 150                 155                 160 


Phe Leu Asn Tyr Tyr Ala Asp Leu Glu Thr Ser Ala Arg Glu Leu Glu 
                165                 170                 175     


Gln Asn Arg Gly Asn His His Gly Thr Ala Glu Glu Lys Ser Gln Pro 
            180                 185                 190         


Val Gln Gly Gln Ala Ser Thr Ile Ile Gly Asn Gly Asp Leu Leu Leu 
        195                 200                 205             


Gln Lys Pro Asn Arg Pro Gln Ser Ser Pro Glu Asp Gly Gln Val Ala 
    210                 215                 220                 


Thr Val Ser Ser Ser Pro Glu Thr Lys Lys Asp His Pro Lys Thr Gly 
225                 230                 235                 240 


Ala Lys Thr Asp Cys Ala Leu His Arg Ile Gln Asn Leu Ala Pro Ser 
                245                 250                 255     


Asp Glu Glu Ser Ser Trp Thr Thr Leu Ser Gln Asp Ser Ala Ser Pro 
            260                 265                 270         


Ser Ser Pro Asp Glu Thr Asp Ile Trp Ser Asp His Ser Phe Gln Thr 
        275                 280                 285             


Asp Pro Asp Leu Pro Pro Gly Trp Lys Arg Val Ser Asp Ile Ala Gly 
    290                 295                 300                 


Thr Tyr Tyr Trp His Ile Pro Thr Gly Thr Thr Gln Trp Glu Arg Pro 
305                 310                 315                 320 


Val Ser Ile Pro Ala Asp Leu Gln Gly Ser Arg Lys Gly Ser Leu Ser 
                325                 330                 335     


Ser Val Thr Pro Ser Pro Thr Pro Glu Asn Glu Lys Gln Pro Trp Ser 
            340                 345                 350         


Asp Phe Ala Val Leu Asn Gly Gly Lys Ile Asn Ser Asp Ile Trp Lys 
        355                 360                 365             


Asp Leu His Ala Ala Thr Val Asn Pro Asp Pro Ser Leu Lys Glu Phe 
    370                 375                 380                 


Glu Gly Ala Thr Leu Arg Tyr Ala Ser Leu Lys Leu Arg Asn Ala Pro 
385                 390                 395                 400 


His Pro Asp Asp Asp Asp Ser Cys Ser Ile Asn Ser Asp Pro Glu Ala 
                405                 410                 415     


Lys Cys Phe Ala Val Arg Ser Leu Gly Trp Val Glu Met Ala Glu Glu 
            420                 425                 430         


Asp Leu Ala Pro Gly Lys Ser Ser Val Ala Val Asn Asn Cys Ile Arg 
        435                 440                 445             


Gln Leu Ser Tyr Cys Lys Asn Asp Ile Arg Asp Thr Val Gly Ile Trp 
    450                 455                 460                 


Gly Glu Gly Lys Asp Met Tyr Leu Ile Leu Glu Asn Asp Met Leu Ser 
465                 470                 475                 480 


Leu Val Asp Pro Met Asp Arg Ser Val Leu His Ser Gln Pro Ile Val 
                485                 490                 495     


Ser Ile Arg Val Trp Gly Val Gly Arg Asp Asn Gly Arg Asp Phe Ala 
            500                 505                 510         


Tyr Val Ala Arg Asp Lys Asp Thr Arg Ile Leu Lys Cys His Val Phe 
        515                 520                 525             


Arg Cys Asp Thr Pro Ala Lys Ala Ile Ala Thr Ser Leu His Glu Ile 
    530                 535                 540                 


Cys Ser Lys Ile Met Ala Glu Arg Lys Asn Ala Lys Ala Leu Ala Cys 
545                 550                 555                 560 


Ser Ser Leu Gln Glu Arg Ala Asn Val Asn Leu Asp Val Pro Leu Gln 
                565                 570                 575     


Val Asp Phe Pro Thr Pro Lys Thr Glu Leu Val Gln Lys Phe His Val 
            580                 585                 590         


Gln Tyr Leu Gly Met Leu Pro Val Asp Lys Pro Val Gly Met Asp Ile 
        595                 600                 605             


Leu Asn Ser Ala Ile Glu Asn Leu Met Thr Ser Ser Asn Lys Glu Asp 
    610                 615                 620                 


Trp Leu Ser Val Asn Met Asn Val Ala Asp Ala Thr Val Thr Val Ile 
625                 630                 635                 640 


Ser Glu Lys Asn Glu Glu Glu Val Leu Val Glu Cys Arg Val Arg Phe 
                645                 650                 655     


Leu Ser Phe Met Gly Val Gly Lys Asp Val His Thr Phe Ala Phe Ile 
            660                 665                 670         


Met Asp Thr Gly Asn Gln Arg Phe Glu Cys His Val Phe Trp Cys Glu 
        675                 680                 685             


Pro Asn Ala Gly Asn Val Ser Glu Ala Val Gln Ala Ala Cys Met Leu 
    690                 695                 700                 


Arg Tyr Gln Lys Cys Leu Val Ala Arg Pro Pro Ser Gln Lys Val Arg 
705                 710                 715                 720 


Pro Pro Pro Pro Pro Ala Asp Ser Val Thr Arg Arg Val Thr Thr Asn 
                725                 730                 735     


Val Lys Arg Gly Val Leu Ser Leu Ile Asp Thr Leu Lys Gln Lys Arg 
            740                 745                 750         


Pro Val Thr Glu Met Pro 
        755             


<210>  48
<211>  2280
<212>  DNA
<213>  Homo sapiens

<400>  48
atgtcagaag tacttccagc tgactcaggt gttgacacct tggcagtgtt tatggccagc       60

agcggaacta cagacgtcac aaatcggaac agcccagcca caccaccaaa cacccttaac      120

ctccgatcct cccacaatga actgttgaac gctgaaataa aacacacaga aaccaagaac      180

agcacacctc ccaaatgcag gaaaaaatat gcactaacta acatccaggc ggccatgggc      240

ctctcggatc cagctgcaca gcccctgctg ggaaatggct ctgccaacat caagctggtg      300

aaaaatgggg agaaccagct ccgtaaggct gcagagcaag ggcagcagga ccccaacaaa      360

aacctgagcc ccactgcagt catcaacata acttctgaga agttagaggg taaagagccc      420

cacccacagg attcctcgag ctgtgagatt ttaccctccc agcccaggag aactaagagc      480

ttcctaaatt actatgcaga tctggaaacc tcagccagag aactagagca gaaccgaggc      540

aatcaccatg ggactgcgga agagaaatcc cagccagtcc agggccaggc ctccaccatc      600

attgggaatg gcgatttgct gctgcagaaa ccaaacagac cccagtccag ccctgaagac      660

ggccaagtag ccacagtgtc atccagccca gaaaccaaga aggatcatcc gaaaacaggg      720

gccaaaaccg actgtgcact gcaccggatc cagaacctgg caccgagcga tgaggagtcc      780

agctggacaa cgttgtccca agacagtgcc tcacccagct ccccggatga aacagcagat      840

atatggagtg atcactcatt tcagactgat ccagatttgc cgcctggctg gaaaagagtc      900

agtgacattg ccgggaccta ttattggcac atcccaacag gaacgactca gtgggaacgg      960

cccgtctcca tcccagcaga tctccagggt tctaggaaag ggtcacttag ttctgtaacg     1020

ccatctccca ccccagagaa cgagaaacag ccatggagtg attttgctgt tctgaatggg     1080

ggaaagatta atagtgacat ttggaaggat ttgcatgcag ccactgttaa cccggacccc     1140

agtttaaaag agtttgaagg agcaacccta cgctatgcat ctttgaaact cagaaatgcc     1200

ccacaccctg atgatgatga ttcttgtagt atcaacagtg acccagaagc caagtgtttt     1260

gctgtgcgtt ctctgggatg ggtagagatg gcagaagagg acctcgcccc cggtaaaagt     1320

agtgttgcgg tcaacaactg catcaggcaa ctttcctact gcaaaaatga catccgagac     1380

acagtcggga tttggggaga ggggaaagac atgtacctga tcctggagaa tgacatgctc     1440

agcctggtgg accccatgga ccgcagcgtg ctgcactcgc agcccatcgt cagcatccgc     1500

gtgtggggcg tgggccgcga caatggccgg gattttgctt atgtagcaag agataaagat     1560

acaagaattt tgaaatgtca tgtatttcga tgtgacacac cagcaaaagc cattgccaca     1620

agtctccacg agatctgctc caagattatg gctgaacgga agaatgccaa agcgctggcc     1680

tgcagctcct tacaggaaag ggccaatgtg aacctcgatg tccctttgca agtagatttt     1740

ccaacaccaa agactgagct ggtccagaag ttccacgtgc agtacttggg catgttacct     1800

gtagacaaac cagtcggaat ggatattttg aacagtgcca tagaaaatct tatgacctca     1860

tccaacaagg aggactggct gtcagtgaac atgaacgtgg ctgatgccac tgtgactgtc     1920

atcagtgaaa agaatgaaga ggaagtctta gtggaatgtc gtgtgcgatt cctgtccttc     1980

atgggtgttg ggaaggacgt ccacacattt gccttcatca tggacacggg gaaccagcgc     2040

tttgagtgcc acgttttctg gtgcgagcct aatgctggta acgtgtctga ggcggtgcag     2100

gccgcctgca tgttacgata tcagaagtgc ttggtagcca ggccgccttc tcagaaagtt     2160

cgaccacctc caccgccagc agattcagta accagaagag tcacaaccaa tgtaaaacga     2220

ggggtcttat ccctcattga cactttgaaa cagaaacgcc ctgtcaccga aatgccatag     2280


<210>  49
<211>  2277
<212>  DNA
<213>  Homo sapiens

<400>  49
atgtcagaag tacttccagc tgactcaggt gttgacacct tggcagtgtt tatggccagc       60

agcggaacta cagacgtcac aaatcggaac agcccagcca caccaccaaa cacccttaac      120

ctccgatcct cccacaatga actgttgaac gctgaaataa aacacacaga aaccaagaac      180

agcacacctc ccaaatgcag gaaaaaatat gcactaacta acatccaggc ggccatgggc      240

ctctcggatc cagctgcaca gcccctgctg ggaaatggct ctgccaacat caagctggtg      300

aaaaatgggg agaaccagct ccgtaaggct gcagagcaag ggcagcagga ccccaacaaa      360

aacctgagcc ccactgcagt catcaacata acttctgaga agttagaggg taaagagccc      420

cacccacagg attcctcgag ctgtgagatt ttaccctccc agcccaggag aactaagagc      480

ttcctaaatt actatgcaga tctggaaacc tcagccagag aactagagca gaaccgaggc      540

aatcaccatg ggactgcgga agagaaatcc cagccagtcc agggccaggc ctccaccatc      600

attgggaatg gcgatttgct gctgcagaaa ccaaacagac cccagtccag ccctgaagac      660

ggccaagtag ccacagtgtc atccagccca gaaaccaaga aggatcatcc gaaaacaggg      720

gccaaaaccg actgtgcact gcaccggatc cagaacctgg caccgagcga tgaggagtcc      780

agctggacaa cgttgtccca agacagtgcc tcacccagct ccccggatga aacagatata      840

tggagtgatc actcatttca gactgatcca gatttgccgc ctggctggaa aagagtcagt      900

gacattgccg ggacctatta ttggcacatc ccaacaggaa cgactcagtg ggaacggccc      960

gtctccatcc cagcagatct ccagggttct aggaaagggt cacttagttc tgtaacgcca     1020

tctcccaccc cagagaacga gaaacagcca tggagtgatt ttgctgttct gaatggggga     1080

aagattaata gtgacatttg gaaggatttg catgcagcca ctgttaaccc ggaccccagt     1140

ttaaaagagt ttgaaggagc aaccctacgc tatgcatctt tgaaactcag aaatgcccca     1200

caccctgatg atgatgattc ttgtagtatc aacagtgacc cagaagccaa gtgttttgct     1260

gtgcgttctc tgggatgggt agagatggca gaagaggacc tcgcccccgg taaaagtagt     1320

gttgcggtca acaactgcat caggcaactt tcctactgca aaaatgacat ccgagacaca     1380

gtcgggattt ggggagaggg gaaagacatg tacctgatcc tggagaatga catgctcagc     1440

ctggtggacc ccatggaccg cagcgtgctg cactcgcagc ccatcgtcag catccgcgtg     1500

tggggcgtgg gccgcgacaa tggccgggat tttgcttatg tagcaagaga taaagataca     1560

agaattttga aatgtcatgt atttcgatgt gacacaccag caaaagccat tgccacaagt     1620

ctccacgaga tctgctccaa gattatggct gaacggaaga atgccaaagc gctggcctgc     1680

agctccttac aggaaagggc caatgtgaac ctcgatgtcc ctttgcaagt agattttcca     1740

acaccaaaga ctgagctggt ccagaagttc cacgtgcagt acttgggcat gttacctgta     1800

gacaaaccag tcggaatgga tattttgaac agtgccatag aaaatcttat gacctcatcc     1860

aacaaggagg actggctgtc agtgaacatg aacgtggctg atgccactgt gactgtcatc     1920

agtgaaaaga atgaagagga agtcttagtg gaatgtcgtg tgcgattcct gtccttcatg     1980

ggtgttggga aggacgtcca cacatttgcc ttcatcatgg acacggggaa ccagcgcttt     2040

gagtgccacg ttttctggtg cgagcctaat gctggtaacg tgtctgaggc ggtgcaggcc     2100

gcctgcatgt tacgatatca gaagtgcttg gtagccaggc cgccttctca gaaagttcga     2160

ccacctccac cgccagcaga ttcagtaacc agaagagtca caaccaatgt aaaacgaggg     2220

gtcttatccc tcattgacac tttgaaacag aaacgccctg tcaccgaaat gccatag        2277


<210>  50
<211>  2211
<212>  DNA
<213>  Homo sapiens

<400>  50
atgtcagaag tacttccagc tgactcaggt gttgacacct tggcagtgtt tatggccagc       60

agcggaacta cagacgtcac aaatcggaac agcccagcca caccaccaaa cacccttaac      120

ctccgatcct cccacaatga actgttgaac gctgaaataa aacacacaga aaccaagaac      180

agcacacctc ccaaatgcag gaaaaaatat gcactaacta acatccaggc ggccatgggc      240

ctctcggatc cagctgcaca gcccctgctg ggaaatggct ctgccaacat caagctggtg      300

aaaaatgggg agaaccagct ccgtaaggct gcagagcaag ggcagcagga ccccaacaaa      360

aacctgagcc ccactgcagt catcaacata acttctgaga agttagaggg taaagagccc      420

cacccacagg attcctcgag ctgtgagatt ttaccctccc agcccaggag aactaagagc      480

ttcctaaatt actatgcaga tctggaaacc tcagccagag aactagagca gaaccgaggc      540

aatcaccatg ggactgcgga agagaaatcc cagccagtcc agggccaggc ctccaccatc      600

attgggaatg gcgatttgct gctgcagaaa ccaaacagac cccagtccag ccctgaagac      660

ggccaagtag ccacagtgtc atccagccca gaaaccaaga aggatcatcc gaaaacaggg      720

gccaaaaccg actgtgcact gcaccggatc cagaacctgg caccgagcga tgaggagtcc      780

agctggacaa cgttgtccca agacagtgcc tcacccagct ccccggatga aacagatata      840

tggagtgatc actcatttca gactgatcca gatttgccgc ctggctggaa aagagtcagt      900

gacattgccg ggacctatta ttggcacatc ccaacaggaa cgactcagtg ggaacggccc      960

gtctccatcc cagcagatct ccagggttct aggaaagggt cacttagttc tgtaacgcca     1020

tctcccaccc cagagaacga ggatttgcat gcagccactg ttaacccgga ccccagttta     1080

aaagagtttg aaggagcaac cctacgctat gcatctttga aactcagaaa tgccccacac     1140

cctgatgatg atgattcttg tagtatcaac agtgacccag aagccaagtg ttttgctgtg     1200

cgttctctgg gatgggtaga gatggcagaa gaggacctcg cccccggtaa aagtagtgtt     1260

gcggtcaaca actgcatcag gcaactttcc tactgcaaaa atgacatccg agacacagtc     1320

gggatttggg gagaggggaa agacatgtac ctgatcctgg agaatgacat gctcagcctg     1380

gtggacccca tggaccgcag cgtgctgcac tcgcagccca tcgtcagcat ccgcgtgtgg     1440

ggcgtgggcc gcgacaatgg ccgggatttt gcttatgtag caagagataa agatacaaga     1500

attttgaaat gtcatgtatt tcgatgtgac acaccagcaa aagccattgc cacaagtctc     1560

cacgagatct gctccaagat tatggctgaa cggaagaatg ccaaagcgct ggcctgcagc     1620

tccttacagg aaagggccaa tgtgaacctc gatgtccctt tgcaagattt tccaacacca     1680

aagactgagc tggtccagaa gttccacgtg cagtacttgg gcatgttacc tgtagacaaa     1740

ccagtcggaa tggatatttt gaacagtgcc atagaaaatc ttatgacctc atccaacaag     1800

gaggactggc tgtcagtgaa catgaacgtg gctgatgcca ctgtgactgt catcagtgaa     1860

aagaatgaag aggaagtctt agtggaatgt cgtgtgcgat tcctgtcctt catgggtgtt     1920

gggaaggacg tccacacatt tgccttcatc atggacacgg ggaaccagcg ctttgagtgc     1980

cacgttttct ggtgcgagcc taatgctggt aacgtgtctg aggcggtgca ggccgcctgc     2040

atgttacgat atcagaagtg cttggtagcc aggccgcctt ctcagaaagt tcgaccacct     2100

ccaccgccag cagattcagt aaccagaaga gtcacaacca atgtaaaacg aggggtctta     2160

tccctcattg acactttgaa acagaaacgc cctgtcaccg aaatgccata g              2211


<210>  51
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  51
atggctgaac ggaagaatgc caaagcgctg gcctgcagct ccttacagga aagggccaat       60

gtgaacctcg atgtcccttt gcaagtagat tttccaacac caaagactga gctggtccag      120

aagttccacg tgcagtactt gggcatgtta cctgtagaca aaccagtcgg aatggatatt      180

ttgaacagtg ccatagaaaa tcttatgacc tcatccaaca aggaggactg gctgtcagtg      240

aacatgaacg tggctgatgc cactgtgact gtcatcagtg aaaagaatga agaggaagtc      300

ttagtggaat gtcgtgtgcg attcctgtcc ttcatgggtg ttgggaagga cgtccacaca      360

tttgccttca tcatggacac ggggaaccag cgctttgagt gccacgtttt ctggtgcgag      420

cctaatgctg gtaacgtgtc tgaggcggtg caggccgcct gcatgttacg atatcagaag      480

tgcttggtag ccaggccgcc ttctcagaaa gttcgaccac ctccaccgcc agcagattca      540

gtaaccagaa gagtcacaac caatgtaaaa cgaggggtct tatccctcat tgacactttg      600

aaacagaaac gccctgtcac cgaaatgcca tag                                   633


<210>  52
<211>  1461
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Leu Ser Val Asp Ser Ser Trp His Arg Trp Gln Trp Arg Val 
1               5                   10                  15      


Arg Asp Gly Phe Pro His Cys Pro Ser Glu Thr Thr Pro Leu Leu Ser 
            20                  25                  30          


Pro Glu Lys Gly Arg Gln Ser Tyr Asn Leu Thr Gln Gln Arg Val Val 
        35                  40                  45              


Phe Pro Asn Asn Ser Ile Phe His Gln Asp Trp Glu Glu Val Ser Arg 
    50                  55                  60                  


Arg Tyr Pro Gly Asn Arg Thr Cys Thr Thr Lys Tyr Thr Leu Phe Thr 
65                  70                  75                  80  


Phe Leu Pro Arg Asn Leu Phe Glu Gln Phe His Arg Trp Ala Asn Leu 
                85                  90                  95      


Tyr Phe Leu Phe Leu Val Ile Leu Asn Trp Met Pro Ser Met Glu Val 
            100                 105                 110         


Phe His Arg Glu Ile Thr Met Leu Pro Leu Ala Ile Val Leu Phe Val 
        115                 120                 125             


Ile Met Ile Lys Asp Gly Met Glu Asp Phe Lys Arg His Arg Phe Asp 
    130                 135                 140                 


Lys Ala Ile Asn Cys Ser Asn Ile Arg Ile Tyr Glu Arg Lys Glu Gln 
145                 150                 155                 160 


Thr Tyr Val Gln Lys Cys Trp Lys Asp Val Arg Val Gly Asp Phe Ile 
                165                 170                 175     


Gln Met Lys Cys Asn Glu Ile Val Pro Ala Asp Ile Leu Leu Leu Phe 
            180                 185                 190         


Ser Ser Asp Pro Asn Gly Ile Cys His Leu Glu Thr Ala Ser Leu Asp 
        195                 200                 205             


Gly Glu Thr Asn Leu Lys Gln Arg Cys Val Val Lys Gly Phe Ser Gln 
    210                 215                 220                 


Gln Glu Val Gln Phe Glu Pro Glu Leu Phe His Asn Thr Ile Val Cys 
225                 230                 235                 240 


Glu Lys Pro Asn Asn His Leu Asn Lys Phe Lys Gly Tyr Met Glu His 
                245                 250                 255     


Pro Asp Gln Thr Arg Thr Gly Phe Gly Cys Glu Ser Leu Leu Leu Arg 
            260                 265                 270         


Gly Cys Thr Ile Arg Asn Thr Glu Met Ala Val Gly Ile Val Ile Tyr 
        275                 280                 285             


Ala Gly His Glu Thr Lys Ala Met Leu Asn Asn Ser Gly Pro Arg Tyr 
    290                 295                 300                 


Lys Arg Ser Lys Ile Glu Arg Arg Met Asn Ile Asp Ile Phe Phe Cys 
305                 310                 315                 320 


Ile Gly Ile Leu Ile Leu Met Cys Leu Ile Gly Ala Val Gly His Ser 
                325                 330                 335     


Ile Trp Asn Gly Thr Phe Glu Glu His Pro Pro Phe Asp Val Pro Asp 
            340                 345                 350         


Ala Asn Gly Ser Phe Leu Pro Ser Ala Leu Gly Gly Phe Tyr Met Phe 
        355                 360                 365             


Leu Thr Met Ile Ile Leu Leu Gln Val Leu Ile Pro Ile Ser Leu Tyr 
    370                 375                 380                 


Val Ser Ile Glu Leu Val Lys Leu Gly Gln Val Phe Phe Leu Ser Asn 
385                 390                 395                 400 


Asp Leu Asp Leu Tyr Asp Glu Glu Thr Asp Leu Ser Ile Gln Cys Arg 
                405                 410                 415     


Ala Leu Asn Ile Ala Glu Asp Leu Gly Gln Ile Gln Tyr Ile Phe Ser 
            420                 425                 430         


Asp Lys Thr Gly Thr Leu Thr Glu Asn Lys Met Val Phe Arg Arg Cys 
        435                 440                 445             


Thr Ile Met Gly Ser Glu Tyr Ser His Gln Glu Asn Ala Lys Arg Leu 
    450                 455                 460                 


Glu Thr Pro Lys Glu Leu Asp Ser Asp Gly Glu Glu Trp Thr Gln Tyr 
465                 470                 475                 480 


Gln Cys Leu Ser Phe Ser Ala Arg Trp Ala Gln Asp Pro Ala Thr Met 
                485                 490                 495     


Arg Ser Gln Lys Gly Ala Gln Pro Leu Arg Arg Ser Gln Ser Ala Arg 
            500                 505                 510         


Val Pro Ile Gln Gly His Tyr Arg Gln Arg Ser Met Gly His Arg Glu 
        515                 520                 525             


Ser Ser Gln Pro Pro Val Ala Phe Ser Ser Ser Ile Glu Lys Asp Val 
    530                 535                 540                 


Thr Pro Asp Lys Asn Leu Leu Thr Lys Val Arg Asp Ala Ala Leu Trp 
545                 550                 555                 560 


Leu Glu Thr Leu Ser Asp Ser Arg Pro Ala Lys Ala Ser Leu Ser Thr 
                565                 570                 575     


Thr Ser Ser Ile Ala Asp Phe Phe Leu Ala Leu Thr Ile Cys Asn Ser 
            580                 585                 590         


Val Met Val Ser Thr Thr Thr Glu Pro Arg Gln Arg Val Thr Ile Lys 
        595                 600                 605             


Pro Ser Ser Lys Ala Leu Gly Thr Ser Leu Glu Lys Ile Gln Gln Leu 
    610                 615                 620                 


Phe Gln Lys Leu Lys Leu Leu Ser Leu Ser Gln Ser Phe Ser Ser Thr 
625                 630                 635                 640 


Ala Pro Ser Asp Thr Asp Leu Gly Glu Ser Leu Gly Ala Asn Val Ala 
                645                 650                 655     


Thr Thr Asp Ser Asp Glu Arg Asp Asp Ala Ser Val Cys Ser Gly Gly 
            660                 665                 670         


Asp Ser Thr Asp Asp Gly Gly Tyr Arg Ser Ser Met Trp Asp Gln Gly 
        675                 680                 685             


Asp Ile Leu Glu Ser Gly Ser Gly Thr Ser Leu Glu Glu Ala Leu Glu 
    690                 695                 700                 


Ala Pro Ala Thr Asp Leu Ala Arg Pro Glu Phe Cys Tyr Glu Ala Glu 
705                 710                 715                 720 


Ser Pro Asp Glu Ala Ala Leu Val His Ala Ala His Ala Tyr Ser Phe 
                725                 730                 735     


Thr Leu Val Ser Arg Thr Pro Glu Gln Val Thr Val Arg Leu Pro Gln 
            740                 745                 750         


Gly Thr Cys Leu Thr Phe Ser Leu Leu Cys Thr Leu Gly Phe Asp Ser 
        755                 760                 765             


Val Arg Lys Arg Met Ser Val Val Val Arg His Pro Leu Thr Gly Glu 
    770                 775                 780                 


Ile Val Val Tyr Thr Lys Gly Ala Asp Ser Val Ile Met Asp Leu Leu 
785                 790                 795                 800 


Glu Asp Pro Ala Cys Val Pro Asp Ile Asn Met Glu Lys Lys Leu Arg 
                805                 810                 815     


Lys Ile Arg Ala Arg Thr Gln Lys His Leu Asp Leu Tyr Ala Arg Asp 
            820                 825                 830         


Gly Leu Arg Thr Leu Cys Ile Ala Lys Lys Val Val Ser Glu Glu Asp 
        835                 840                 845             


Phe Arg Arg Trp Ala Ser Phe Arg Arg Glu Ala Glu Ala Ser Leu Asp 
    850                 855                 860                 


Asn Arg Asp Glu Leu Leu Met Glu Thr Ala Gln His Leu Glu Asn Gln 
865                 870                 875                 880 


Leu Thr Leu Leu Gly Ala Thr Gly Ile Glu Asp Arg Leu Gln Glu Gly 
                885                 890                 895     


Val Pro Asp Thr Ile Ala Thr Leu Arg Glu Ala Gly Ile Gln Leu Trp 
            900                 905                 910         


Val Leu Thr Gly Asp Lys Gln Glu Thr Ala Val Asn Ile Ala His Ser 
        915                 920                 925             


Cys Arg Leu Leu Asn Gln Thr Asp Thr Val Tyr Thr Ile Asn Thr Glu 
    930                 935                 940                 


Asn Gln Glu Thr Cys Glu Ser Ile Leu Asn Cys Ala Leu Glu Glu Leu 
945                 950                 955                 960 


Lys Gln Phe Arg Glu Leu Gln Lys Pro Asp Arg Lys Leu Phe Gly Phe 
                965                 970                 975     


Arg Leu Pro Ser Lys Thr Pro Ser Ile Thr Ser Glu Ala Val Val Pro 
            980                 985                 990         


Glu Ala Gly Leu Val Ile Asp Gly  Lys Thr Leu Asn Ala  Ile Phe Gln 
        995                 1000                 1005             


Gly Lys  Leu Glu Lys Lys Phe  Leu Glu Leu Thr Gln  Tyr Cys Arg 
    1010                 1015                 1020             


Ser Val  Leu Cys Cys Arg Ser  Thr Pro Leu Gln Lys  Ser Met Ile 
    1025                 1030                 1035             


Val Lys  Leu Val Arg Asp Lys  Leu Arg Val Met Thr  Leu Ser Ile 
    1040                 1045                 1050             


Gly Asp  Gly Ala Asn Asp Val  Ser Met Ile Gln Ala  Ala Asp Ile 
    1055                 1060                 1065             


Gly Ile  Gly Ile Ser Gly Gln  Glu Gly Met Gln Ala  Val Met Ser 
    1070                 1075                 1080             


Ser Asp  Phe Ala Ile Thr Arg  Phe Lys His Leu Lys  Lys Leu Leu 
    1085                 1090                 1095             


Leu Val  His Gly His Trp Cys  Tyr Ser Arg Leu Ala  Arg Met Val 
    1100                 1105                 1110             


Val Tyr  Tyr Leu Tyr Lys Asn  Val Cys Tyr Val Asn  Leu Leu Phe 
    1115                 1120                 1125             


Trp Tyr  Gln Phe Phe Cys Gly  Phe Ser Ser Ser Thr  Met Ile Asp 
    1130                 1135                 1140             


Tyr Trp  Gln Met Ile Phe Phe  Asn Leu Phe Phe Thr  Ser Leu Pro 
    1145                 1150                 1155             


Pro Leu  Val Phe Gly Val Leu  Asp Lys Asp Ile Ser  Ala Glu Thr 
    1160                 1165                 1170             


Leu Leu  Ala Leu Pro Glu Leu  Tyr Lys Ser Gly Gln  Asn Ser Glu 
    1175                 1180                 1185             


Cys Tyr  Asn Leu Ser Thr Phe  Trp Ile Ser Met Val  Asp Ala Phe 
    1190                 1195                 1200             


Tyr Gln  Ser Leu Ile Cys Phe  Phe Ile Pro Tyr Leu  Ala Tyr Lys 
    1205                 1210                 1215             


Gly Ser  Asp Ile Asp Val Phe  Thr Phe Gly Thr Pro  Ile Asn Thr 
    1220                 1225                 1230             


Ile Ser  Leu Thr Thr Ile Leu  Leu His Gln Ala Met  Glu Met Lys 
    1235                 1240                 1245             


Thr Trp  Thr Ile Phe His Gly  Val Val Leu Leu Gly  Ser Phe Leu 
    1250                 1255                 1260             


Met Tyr  Phe Leu Val Ser Leu  Leu Tyr Asn Ala Thr  Cys Val Ile 
    1265                 1270                 1275             


Cys Asn  Ser Pro Thr Asn Pro  Tyr Trp Val Met Glu  Gly Gln Leu 
    1280                 1285                 1290             


Ser Asn  Pro Thr Phe Tyr Leu  Val Cys Phe Leu Thr  Pro Val Val 
    1295                 1300                 1305             


Ala Leu  Leu Pro Arg Tyr Phe  Phe Leu Ser Leu Gln  Gly Thr Cys 
    1310                 1315                 1320             


Gly Lys  Ser Leu Ile Ser Lys  Ala Gln Lys Ile Asp  Lys Leu Pro 
    1325                 1330                 1335             


Pro Asp  Lys Arg Asn Leu Glu  Ile Gln Ser Trp Arg  Ser Arg Gln 
    1340                 1345                 1350             


Arg Pro  Ala Pro Val Pro Glu  Val Ala Arg Pro Thr  His His Pro 
    1355                 1360                 1365             


Val Ser  Ser Ile Thr Gly Gln  Asp Phe Ser Ala Ser  Thr Pro Lys 
    1370                 1375                 1380             


Ser Ser  Asn Pro Pro Lys Arg  Lys His Val Glu Glu  Ser Val Leu 
    1385                 1390                 1395             


His Glu  Gln Arg Cys Gly Thr  Glu Cys Met Arg Asp  Asp Ser Cys 
    1400                 1405                 1410             


Ser Gly  Asp Ser Ser Ala Gln  Leu Ser Ser Gly Glu  His Leu Leu 
    1415                 1420                 1425             


Gly Pro  Asn Arg Ile Met Ala  Tyr Ser Arg Gly Gln  Thr Asp Met 
    1430                 1435                 1440             


Cys Arg  Cys Ser Lys Arg Ser  Ser His Arg Arg Ser  Gln Ser Ser 
    1445                 1450                 1455             


Leu Thr  Ile 
    1460     


<210>  53
<211>  4386
<212>  DNA
<213>  Homo sapiens

<400>  53
atggccctct cagtggactc atcgtggcat cggtggcagt ggagagtcag agatggcttc       60

ccccattgtc catcggaaac cacaccgctg ctctctccag agaaagggag acagagctac      120

aacttgacac agcagcgggt cgtgttcccc aacaacagca tattccatca agattgggaa      180

gaggtctcca ggagataccc tggcaacaga acctgcacaa ccaaatacac cctcttcacc      240

ttcctgcccc ggaatctctt tgagcaattt catagatggg ctaacctcta tttcctgttc      300

ctggtgattt tgaactggat gccctccatg gaagtcttcc acagagaaat caccatgtta      360

ccattggcca ttgtcctgtt cgtcatcatg atcaaggatg gcatggagga cttcaagaga      420

caccgctttg ataaagcaat aaactgctcc aacattcgaa tttatgaaag aaaagagcag      480

acctatgtgc agaagtgctg gaaggatgtg cgcgtgggag acttcatcca aatgaaatgc      540

aatgagattg tcccagcaga catactcctc cttttttcct ctgaccccaa tgggatatgc      600

catctggaaa ctgccagctt ggatggagag acaaacctca agcaaagatg tgtcgtgaag      660

ggcttctcac agcaggaggt acagttcgaa ccagagcttt tccacaatac catcgtgtgt      720

gagaaaccca acaaccacct caacaaattt aagggttata tggagcatcc tgaccagacc      780

aggactggct ttggctgtga gagtcttctg cttcgaggct gcaccatcag aaacaccgag      840

atggctgttg gcattgtcat ctatgcaggc catgagacga aagccatgct gaacaacagt      900

ggcccccggt acaaacgcag caagattgag cggcgcatga atatagacat cttcttctgc      960

attgggatcc tcatcctcat gtgccttatt ggagctgtag gtcacagcat ctggaatggg     1020

acctttgaag aacaccctcc cttcgatgtg ccagatgcca atggcagctt ccttcccagt     1080

gcccttgggg gcttctacat gttcctcaca atgatcatcc tgctccaggt gctgatcccc     1140

atctctttgt atgtctccat tgagctggtg aagctcgggc aagtgttctt cttgagcaat     1200

gaccttgacc tgtatgatga agagaccgat ttatccattc aatgtcgagc cctcaacatc     1260

gcagaggact tgggccagat ccagtacatc ttctccgata agacggggac cctgacagag     1320

aacaagatgg tgttccgacg ttgcaccatc atgggcagcg agtattctca ccaagaaaat     1380

gctaagcgac tggagacccc aaaggagctg gactcagatg gtgaagagtg gacccaatac     1440

caatgcctgt ccttctcggc tagatgggcc caggatccag caactatgag aagccaaaaa     1500

ggtgctcagc ctctgaggag gagccagagt gcccgggtgc ccatccaggg ccactaccgg     1560

caaaggtcta tggggcaccg tgaaagctca cagcctcctg tggccttcag cagctccata     1620

gaaaaagatg taactccaga taaaaaccta ctgaccaagg ttcgagatgc tgccctgtgg     1680

ttggagacct tgtcagacag cagacctgcc aaggcttccc tctccaccac ctcctccatt     1740

gctgatttct tccttgcctt aaccatctgc aactctgtca tggtgtccac aaccaccgag     1800

cccaggcaga gggtcaccat caaaccctca agcaaggctc tggggacgtc cctggagaag     1860

attcagcagc tcttccagaa gttgaagcta ttgagcctca gccagtcatt ctcatccact     1920

gcaccctctg acacagacct cggggagagc ttaggggcca acgtggccac cacagactcg     1980

gatgagagag atgatgcatc tgtgtgcagt ggaggtgact ccactgatga cggtggctac     2040

aggagcagca tgtgggacca gggcgacatc ctggagtctg ggtcaggcac ttccttggag     2100

gaggcattgg aggccccagc cacagacctg gccaggcctg agttctgtta cgaggctgag     2160

agccctgatg aggccgccct ggtgcacgct gcccatgcct acagcttcac actagtgtcc     2220

cggacacctg agcaggtgac tgtgcgcctg ccccagggca cctgcctcac cttcagcctc     2280

ctctgcaccc tgggctttga ctctgtcagg aagagaatgt ctgtggttgt gaggcaccca     2340

ctgactggcg agattgttgt ctacaccaag ggtgctgact cggtcatcat ggacctgctg     2400

gaagacccag cctgcgtacc tgacattaat atggaaaaga agctgagaaa aatccgagcc     2460

cggacccaaa agcatctaga cttgtatgca agagatggcc tgcgcacact atgcattgcc     2520

aagaaggttg taagcgaaga ggacttccgg agatgggcca gtttccggcg tgaggctgag     2580

gcatccctcg acaaccgaga tgagcttctc atggaaactg cacagcatct ggagaatcaa     2640

ctcaccttac ttggagccac tgggatcgaa gaccggctgc aggaaggagt tccagatacg     2700

attgccactc tgcgggaggc tgggatccag ctctgggtcc tgactggaga taagcaggag     2760

acagcggtca acattgccca ttcctgcaga ctgttaaatc agaccgacac tgtttatacc     2820

atcaatacag agaatcagga gacctgtgaa tccatcctca attgtgcatt ggaagagcta     2880

aagcaatttc gtgaactaca gaagccagac cgcaagctct ttggattccg cttaccttcc     2940

aagacaccat ccatcacctc agaagctgtg gttccagaag ctggattggt catcgatggg     3000

aagacattga atgccatctt ccagggaaag ctagagaaga agtttctgga attgacccag     3060

tattgtcggt ccgtcctgtg ctgccgctcc acgccactcc agaagagtat gatagtcaag     3120

ctggtgcgag acaagttgcg cgtcatgacc ctttccatag gtgatggagc aaatgatgta     3180

agcatgattc aagctgctga tattggaatt ggaatatctg gacaggaagg catgcaggct     3240

gtcatgtcca gcgactttgc catcacccgc tttaagcatc tcaagaagtt gctgctcgtg     3300

catggccact ggtgttactc gcgcctggcc aggatggtgg tgtactacct ctacaagaac     3360

gtgtgctacg tcaacctgct cttctggtat cagttcttct gtggtttctc cagctccacc     3420

atgattgatt actggcagat gatattcttc aatctcttct ttacctcctt gcctcctctt     3480

gtctttggag tccttgacaa agacatctct gcagaaacac tcctggcatt gcctgagcta     3540

tacaagagtg gccagaactc tgagtgctat aacctgtcga ctttctggat ttctatggtg     3600

gatgcattct accagagcct catctgtttc tttatccctt acctggccta taagggctct     3660

gatatagatg tctttacctt tgggacacca atcaacacca tctccctcac cacaatcctt     3720

ttgcaccagg caatggaaat gaagacatgg accattttcc acggagtcgt gctcctcggc     3780

agcttcctga tgtactttct ggtatccctc ctgtacaatg ccacctgcgt catctgcaac     3840

agccccacca atccctattg ggtgatggaa ggccagctct caaaccccac tttctacctc     3900

gtctgctttc tcacaccagt tgttgctctt ctcccaagat actttttcct gtctctgcaa     3960

ggaacttgtg ggaagtctct aatctcaaaa gctcagaaaa ttgacaaact ccccccagac     4020

aaaagaaacc tggaaatcca gagttggaga agcagacaga ggcctgcccc tgtccccgaa     4080

gtggctcgac caactcacca cccagtgtca tctatcacag gacaggactt cagtgccagc     4140

accccaaaga gctctaaccc tcccaagagg aagcatgtgg aagagtcagt actccacgaa     4200

cagagatgtg gcacggagtg catgagggat gactcatgct caggggactc ctcagctcaa     4260

ctctcatccg gggagcacct gctgggacct aacaggataa tggcctactc aagaggacag     4320

actgatatgt gccggtgctc aaagaggagc agccatcgcc gatcccagag ttcactgacc     4380

atatga                                                                4386


<210>  54
<211>  327
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile Pro Leu Asp Asp 
1               5                   10                  15      


Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala Tyr Tyr Thr Arg 
            20                  25                  30          


His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn Cys Ser Ala Asn 
    50                  55                  60                  


Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn Ser Gln Ser Ser 
65                  70                  75                  80  


Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser Trp Lys Ala Phe 
                85                  90                  95      


Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr Pro Ala Lys Val 
            100                 105                 110         


Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp Ser His Ser Gln 
        115                 120                 125             


Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys Leu Glu His Glu 
    130                 135                 140                 


Ala Val Asp Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile 
145                 150                 155                 160 


Val Tyr Ser Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys 
                165                 170                 175     


Ser Lys Glu Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly 
            180                 185                 190         


His Val Pro Val A