                         SEQUENCE LISTING

<110>  Emergent Product Development Seattle, LLC
 
<120>  ANTI-SIL6XR COMPLEX BINDING DOMAINS AND METHODS OF USE

<130>  EMER-018/01WO

<150>  US 61/561,108
<151>  2011-11-17

<160>  754   

<170>  PatentIn version 3.5

<210>  1
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  anti-human hyper IL-6 binding domain derived from a DYAX phage 
       display library

<400>  1
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ttttaccaga tgcattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctggt atctatcctt ctggtggcta tactaagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagagatcta      300

gggtacggca gcagctggta ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcaagcggtg gcggcggttc ggggggtggc ggaagtggag gtggagggag tcagagcgct      420

ttgactcagc ctgcctccgt gtctgggtct cctggacagt cgatcaccat ctcctgcagt      480

ggaaccgaca gtgacgttgg tggttataac catgtctcct ggtaccaaca acacccaggc      540

aaggccccca aactcataat ttatgatgtc gatcatcggc cctcagggat ctctaaccgt      600

ttctctggct ccaagtctgg caacacggcc tccctgacca tctctgggct ccaggctgag      660

gacgaggctg attattactg cagctcatat agaagcggta gcacttatgt cttcggaact      720

gggaccaagg tcaccgtcct aaccggtgag cccaaatctt ctgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagccgg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaatga                                                                1446


<210>  2
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2 is an anti-human hyper IL-6 binding domain derived from a DYAX
       phage display library

<400>  2

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asp His 
            180                 185                 190         


Arg Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Val Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Thr Gly Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  3
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the A2 binding domain

<400>  3

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  4
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL or the A2 binding domain

<400>  4

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Ser Thr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  5
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR1 of the A2 binding domain

<400>  5

Phe Tyr Gln Met His 
1               5   


<210>  6
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR2 of the A2 binding domain

<400>  6

Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly Arg 
        


<210>  7
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of the A2 binding domain

<400>  7

Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  8
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR1 of the A2 binding domain

<400>  8

Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser 
1               5                   10                  


<210>  9
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR2 of the A2 binding domain

<400>  9

Asp Val Asp His Arg Pro Ser 
1               5           


<210>  10
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of the A2 binding domain

<400>  10

Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Val 
1               5                   10  


<210>  11
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A2M1 anti-hyper IL-6 binding domain

<400>  11
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ttttaccaga tgcattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctggt atctatcctt ctggtggcta tactaagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagagatcta      300

gggtacggca gcacgtggta ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcaagcggtg gcggcggttc ggggggtggc ggaagtggag gtggagggag tcagagcgct      420

ttgactcagc ctgcctccgt gtctgggtct cctggacagt cgatcaccat ctcctgcagt      480

ggaaccgaca gtgacgttgg tggttataac catgtctcct ggtaccaaca acacccaggc      540

aaggccccca aactcataat ttatgatgtc gatcatcggc cctcagggat ctctaaccgt      600

ttctctggct ccaagtctgg caacacggcc tccctgacca tctctgggct ccaggctgag      660

gacgaggctg attattactg cagctcatat agaagcggta gcacttatcc tttcggaact      720

gggaccaagg tcaccgtcct aaccggtgag cccaaatctt ctgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagccgg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaatga                                                                1446


<210>  12
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2M1 anti-hyper IL-6 binding domain

<400>  12

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Thr Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asp His 
            180                 185                 190         


Arg Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Pro Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Thr Gly Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  13
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the A2M1 binding domain

<400>  13

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Thr Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  14
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the A2M1 binding domain

<400>  14

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Ser Thr Tyr Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  15
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH CDR3 of the A2M1 binding domain

<400>  15

Asp Leu Gly Tyr Gly Ser Thr Trp Tyr Tyr Phe Asp Tyr 
1               5                   10              


<210>  16
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of the A2M1 binding domain

<400>  16

Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Pro 
1               5                   10  


<210>  17
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A2.V237P mutation anti-hyper IL-6 binding domain

<400>  17
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ttttaccaga tgcattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctggt atctatcctt ctggtggcta tactaagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagagatcta      300

gggtacggca gcagctggta ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcaagcggtg gcggcggttc ggggggtggc ggaagtggag gtggagggag tcagagcgct      420

ttgactcagc ctgcctccgt gtctgggtct cctggacagt cgatcaccat ctcctgcagt      480

ggaaccgaca gtgacgttgg tggttataac catgtctcct ggtaccaaca acacccaggc      540

aaggccccca aactcataat ttatgatgtc gatcatcggc cctcagggat ctctaaccgt      600

ttctctggct ccaagtctgg caacacggcc tccctgacca tctctgggct ccaggctgag      660

gacgaggctg attattactg cagctcatat agaagcggta gcacttatcc tttcggaact      720

gggaccaagg tcaccgtcct aaccggtgag cccaaatctt ctgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagccgg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaatga                                                                1446


<210>  18
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2.V237P mutation anti-hyper IL-6 binding domain

<400>  18

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asp His 
            180                 185                 190         


Arg Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Pro Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Thr Gly Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  19
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the A2.V237P mutation binding domain

<400>  19

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  20
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the A2.V237P mutation binding domain

<400>  20

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Ser Thr Tyr Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of the A2.V237P mutation binding domain

<400>  21

Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Pro 
1               5                   10  


<210>  22
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A2 S234E V237P mutation anti-hyper IL-6 binding domain

<400>  22
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ttttaccaga tgcattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctggt atctatcctt ctggtggcta tactaagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagagatcta      300

gggtacggca gcagctggta ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcaagcggtg gcggcggttc ggggggtggc ggaagtggag gtggagggag tcagagcgct      420

ttgactcagc ctgcctccgt gtctgggtct cctggacagt cgatcaccat ctcctgcagt      480

ggaaccgaca gtgacgttgg tggttataac catgtctcct ggtaccaaca acacccaggc      540

aaggccccca aactcataat ttatgatgtc gatcatcggc cctcagggat ctctaaccgt      600

ttctctggct ccaagtctgg caacacggcc tccctgacca tctctgggct ccaggctgag      660

gacgaggctg attattactg cagctcatat agaagcggtg agacttatcc tttcggaact      720

gggaccaagg tcaccgtcct aaccggtgag cccaaatctt ctgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagccgg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaatga                                                                1446


<210>  23
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2 S234E V237P mutation anti-hyper IL-6 binding domain

<400>  23

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asp His 
            180                 185                 190         


Arg Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly Glu Thr Tyr Pro Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Thr Gly Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  24
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the A2 S234E V237P mutant binding domain

<400>  24

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  25
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the A2 S234E V237P mutant binding domain

<400>  25

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Glu Thr Tyr Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of the A2 S234E V237P mutant binding domain

<400>  26

Ser Ser Tyr Arg Ser Gly Glu Thr Tyr Pro 
1               5                   10  


<210>  27
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  A2 S105T S234E V237P mutant anti-hyper IL-6 binding domain

<400>  27
gaagttcaat tgttagagtc tggtggcggt cttgttcagc ctggtggttc tttacgtctt       60

tcttgcgctg cttccggatt cactttctct ttttaccaga tgcattgggt tcgccaagct      120

cctggtaaag gtttggagtg ggtttctggt atctatcctt ctggtggcta tactaagtat      180

gctgactccg ttaaaggtcg cttcactatc tctagagaca actctaagaa tactctctac      240

ttgcagatga acagcttaag ggctgaggac actgcagtct actattgtgc gagagatcta      300

gggtacggca gcacgtggta ctactttgac tactggggcc agggaaccct ggtcaccgtc      360

tcaagcggtg gcggcggttc ggggggtggc ggaagtggag gtggagggag tcagagcgct      420

ttgactcagc ctgcctccgt gtctgggtct cctggacagt cgatcaccat ctcctgcagt      480

ggaaccgaca gtgacgttgg tggttataac catgtctcct ggtaccaaca acacccaggc      540

aaggccccca aactcataat ttatgatgtc gatcatcggc cctcagggat ctctaaccgt      600

ttctctggct ccaagtctgg caacacggcc tccctgacca tctctgggct ccaggctgag      660

gacgaggctg attattactg cagctcatat agaagcggtg agacttatcc tttcggaact      720

gggaccaagg tcaccgtcct aaccggtgag cccaaatctt ctgacaaaac tcacacatgc      780

ccaccgtgcc cagcacctga agccgcgggt gcaccgtcag tcttcctctt ccccccaaaa      840

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      900

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      960

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc     1020

accgtcctgc accaggactg gctgaatggc aaggcgtacg cgtgcgcggt ctccaacaaa     1080

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1140

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1200

tgcctggtca aaggcttcta tccaagcgac atcgccgtgg agtgggagag caatgggcag     1260

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1320

tacagcaagc tcaccgtgga caagagccgg tggcagcagg ggaacgtctt ctcatgctcc     1380

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1440

aaatga                                                                1446


<210>  28
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2 S105T S234E V237P mutant anti-hyper IL-6 binding domain

<400>  28

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Thr Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro 
    130                 135                 140                 


Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser 
145                 150                 155                 160 


Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln 
                165                 170                 175     


Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asp His 
            180                 185                 190         


Arg Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn 
        195                 200                 205             


Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp 
    210                 215                 220                 


Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly Glu Thr Tyr Pro Phe Gly Thr 
225                 230                 235                 240 


Gly Thr Lys Val Thr Val Leu Thr Gly Glu Pro Lys Ser Ser Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Ala 
            340                 345                 350         


Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  29
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VH of the A2 S105T S234E V237P mutant binding domain

<400>  29

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr 
            20                  25                  30          


Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Leu Gly Tyr Gly Ser Thr Trp Tyr Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val 
        115                 120 


<210>  30
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL of the A2 S105T S234E V237P mutant binding domain

<400>  30

Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr 
            20                  25                  30          


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Ile Ile Tyr Asp Val Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
                85                  90                  95      


Glu Thr Tyr Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110 


<210>  31
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VL CDR3 of the A2 S105T S234E V237P mutant binding domain

<400>  31

Ser Ser Tyr Arg Ser Gly Glu Thr Tyr Pro 
1               5                   10  


<210>  32
<211>  249
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2 scFV binding domain

<400>  32

Asn Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
1               5                   10                  15      


Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 
            20                  25                  30          


Phe Tyr Gln Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ser Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Ala Arg Asp Leu Gly Tyr Gly Ser Ser Trp Tyr Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr 
    130                 135                 140                 


Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser 
145                 150                 155                 160 


Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp 
                165                 170                 175     


Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val 
            180                 185                 190         


Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser 
        195                 200                 205             


Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Val Phe 
225                 230                 235                 240 


Gly Thr Gly Thr Lys Val Thr Val Leu 
                245                 


<210>  33
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  (G4S)3 linker of A2 scFV binding domain

<400>  33

Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  34
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 hinge

<400>  34

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  35
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 CH2CH3 domain with mutations

<400>  35

Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  36

<400>  36
000

<210>  37
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Upper hinge region as found in IgG1

<400>  37

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  38
<211>  7
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Upper hinge region as found in IgG2

<400>  38

Glu Arg Lys Cys Cys Val Glu 
1               5           


<210>  39
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Upper hinge region as found in IgG3

<400>  39

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  40
<211>  10
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Upper hinge region as found in IgG3

<400>  40

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
1               5                   10  


<210>  41
<211>  7
<212>  PRT
<213>  Homo Sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  Upper hinge region as found in IgG4

<400>  41

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  42
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Core hinge region as found in IgG1 and IgG2

<400>  42

Cys Pro Pro Cys Pro 
1               5   


<210>  43
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Core hinge region as found in IgG3

<400>  43

Cys Pro Arg Cys Pro 
1               5   


<210>  44
<211>  5
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  Core hing region as found in IgG4

<400>  44

Cys Pro Ser Cys Pro 
1               5   


<210>  45
<211>  17
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  IgG3 upper/core hinges in tandem

<400>  45

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  46
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  IgG3 upper/core hinges in tandem

<400>  46

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  47
<211>  34
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(34)
<223>  IgD upper hinge regions in tandem

<400>  47

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr 
        


<210>  48
<211>  24
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(24)
<223>  IgD upper hinge regions in tandem

<400>  48

Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln 
1               5                   10                  15      


Glu Glu Arg Glu Thr Lys Thr Pro 
            20                  


<210>  49
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Wild type upper hinge region found in IgA1

<400>  49

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapines


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  Wild type upper hinge region found in IgA2

<400>  50

Val Pro Pro Pro Pro Pro 
1               5       


<210>  51
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type CH2 upper hinge-like sequence of IgE

<400>  51

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Ser Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
            100                 105         


<210>  52
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  Wild type CH2 upper hinge-like sequence of IgM

<400>  52

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


<210>  53
<211>  58
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(58)
<223>  Human wild type immunoglobulin hinge region, IgD

<400>  53

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  54
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Human wilid type immunoglobulin hinge region, IgG1

<400>  54

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  55
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Human wild type immunoglobulin hinge region, IgG2

<400>  55

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  56
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(62)
<223>  Human wild type immunoglobulin hinge region, IgG3

<400>  56

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  57
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Human wild type immunoglobulin hinge region, IgG4

<400>  57

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (SCC-P)

<400>  58

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  59
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (SSC-P)

<400>  59

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  60
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (SSS-P)

<400>  60

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  61
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CSC-P)

<400>  61

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  62
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CSS-P)

<400>  62

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CCS-P)

<400>  63

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  64
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (SCC-S)

<400>  64

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  65
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (SSC-S)

<400>  65

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  66
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (SSS-S)

<400>  66

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  67
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CSC-S)

<400>  67

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  68
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CSS-S)

<400>  68

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  69
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CCS-S)

<400>  69

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  70
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human CH2 upper hinge like sequence of IgE

<400>  70

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Ser Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Ser Ala 
            100                 105         


<210>  71
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Hinge Variant (SCC-P) with C-2 AA junction

<400>  71

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ser 
1               5                   10                  15      


Gly 
    


<210>  72
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Hinge Variant (SCC-P) with N-2 AA junction

<400>  72

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  73
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Hinge Variant (SCC-P) with N- and C-2 AA junctions

<400>  73

Ser Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  74
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 Hinge Variant (SCC-P) with N- and C-2 AA junctions

<400>  74

Arg Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro Ser Gly 
            


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-CH1 linker

<400>  75

Gly Gly Gly Ser Ser 
1               5   


<210>  76
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-CH1 linker derived from NKG2D

<400>  76

Ser Tyr Ser Pro Asn Ser 
1               5       


<210>  77
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-CH1 linker derived from NKG2A

<400>  77

Ser Ser Leu Asn Thr Pro Asn Ser 
1               5               


<210>  78
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-Ck linker

<400>  78

Gly Gly Gly Ser Arg 
1               5   


<210>  79
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-Ck linker derived from NKG2D

<400>  79

Ser Tyr Ser Pro Asn Ser Arg 
1               5           


<210>  80
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-Ck linker derived from NKG2A

<400>  80

Ser Ser Leu Asn Thr Pro Asn Ser Arg 
1               5                   


<210>  81
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CH3-CH1 linker

<400>  81

Lys Ser Arg 
1           


<210>  82
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  82

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val Arg Thr 
            100 


<210>  83
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(102)
<223>  Wild type human CH1 region

<400>  83

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro 
            100         


<210>  84
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(102)
<223>  Wild type human CH1 region

<400>  84

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro 
            100         


<210>  85
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Wild type human CH1 region

<400>  85

Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro 
            100     


<210>  86
<211>  103
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  Wild type human CH1 region

<400>  86

Ala Ser Thr Gln Ser Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys 
1               5                   10                  15      


Asn Ile Pro Ser Asn Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr 
            20                  25                  30          


Gly Tyr Phe Pro Glu Pro Val Met Val Thr Cys Asp Thr Gly Ser Leu 
        35                  40                  45              


Asn Gly Thr Thr Met Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly 
    50                  55                  60                  


His Tyr Ala Thr Ile Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys 
65                  70                  75                  80  


Gln Met Phe Thr Cys Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp 
                85                  90                  95      


Val Asp Asn Lys Thr Phe Ser 
            100             


<210>  87
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human CH1 region

<400>  87

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  88
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human CH1 region

<400>  88

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  89
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human CH1 region

<400>  89

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  90
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(104)
<223>  Wild type human CH1 region

<400>  90

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro 
            100                 


<210>  91
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human C kappa region

<400>  91

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  92
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human C lambda region

<400>  92

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  93
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human C lambda region

<400>  93

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Lys Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  94
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human C lambda region

<400>  94

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Lys Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Asn Thr Gly Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  95
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human C lambda region

<400>  95

Gly Gln Pro Lys Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Val Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Val Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Arg Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Ala Glu Cys Ser 
            100                 105     


<210>  96
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Wild type human CH2 domain

<400>  96

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  97
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Wild type human CH2 domain

<400>  97

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Val Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Glu Pro Trp Asn His Gly Lys Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala Tyr Pro Glu Ser Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Thr Leu Ser Lys Ser 
            100     


<210>  98
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Wild type human CH2 domain

<400>  98

Cys Cys His Pro Arg Leu Ser Leu His Arg Pro Ala Leu Glu Asp Leu 
1               5                   10                  15      


Leu Leu Gly Ser Glu Ala Asn Leu Thr Cys Thr Leu Thr Gly Leu Arg 
            20                  25                  30          


Asp Ala Ser Gly Ala Thr Phe Thr Trp Thr Pro Ser Ser Gly Lys Ser 
        35                  40                  45              


Ala Val Gln Gly Pro Pro Glu Arg Asp Leu Cys Gly Cys Tyr Ser Val 
    50                  55                  60                  


Ser Ser Val Leu Pro Gly Cys Ala Gln Pro Trp Asn His Gly Glu Thr 
65                  70                  75                  80  


Phe Thr Cys Thr Ala Ala His Pro Glu Leu Lys Thr Pro Leu Thr Ala 
                85                  90                  95      


Asn Ile Thr Lys Ser 
            100     


<210>  99
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  Wild type human CH2 domain

<400>  99

Glu Cys Pro Ser His Thr Gln Pro Leu Gly Val Tyr Leu Leu Thr Pro 
1               5                   10                  15      


Ala Val Gln Asp Leu Trp Leu Arg Asp Lys Ala Thr Phe Thr Cys Phe 
            20                  25                  30          


Val Val Gly Ser Asp Leu Lys Asp Ala His Leu Thr Trp Glu Val Ala 
        35                  40                  45              


Gly Lys Val Pro Thr Gly Gly Val Glu Glu Gly Leu Leu Glu Arg His 
    50                  55                  60                  


Ser Asn Gly Ser Gln Ser Gln His Ser Arg Leu Thr Leu Pro Arg Ser 
65                  70                  75                  80  


Leu Trp Asn Ala Gly Thr Ser Val Thr Cys Thr Leu Asn His Pro Ser 
                85                  90                  95      


Leu Pro Pro Gln Arg Leu Met Ala Leu Arg Glu Pro 
            100                 105             


<210>  100
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human CH2 domain

<400>  100

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Cys Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
            100                 105         


<210>  101
<211>  109
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(109)
<223>  Wild type human CH2 domain

<400>  101

Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 


<210>  102
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Wild type human CH2 domain

<400>  102

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
            100                 105                 110 


<210>  103
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Wild type human CH2 domain

<400>  103

Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  104
<211>  112
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(112)
<223>  Wild type human CH2 domain

<400>  104

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


<210>  105
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human CH3 domain

<400>  105

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  106
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Wild type human CH3 domain

<400>  106

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  107
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Wild type human CH3 domain

<400>  107

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  108
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(117)
<223>  Wild type human CH3 domain

<400>  108

Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser 
1               5                   10                  15      


Asp Pro Pro Glu Ala Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe 
            20                  25                  30          


Ser Pro Pro Asn Ile Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val 
        35                  40                  45              


Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser 
    50                  55                  60                  


Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Gln Pro Ala Thr Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg 
                85                  90                  95      


Thr Leu Leu Asn Ala Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp 
            100                 105                 110         


His Gly Pro Met Lys 
        115         


<210>  109
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  Wild type human CH3 domain

<400>  109

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105             


<210>  110
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human CH3 domain

<400>  110

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  111
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human CH3 domain

<400>  111

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  112
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human CH3 domain

<400>  112

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  113
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human CH3 domain

<400>  113

Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
            20                  25                  30          


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
        35                  40                  45              


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
    50                  55                  60                  


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
65                  70                  75                  80  


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
                85                  90                  95      


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys 
            100                 105     


<210>  114
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Wild type human CH4 domain

<400>  114

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            100                 105                 110 


<210>  115
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Wild type human CH4 domain

<400>  115

Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg 
1               5                   10                  15      


Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr 
            20                  25                  30          


Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln 
        35                  40                  45              


Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro 
    50                  55                  60                  


Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu 
65                  70                  75                  80  


Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu 
                85                  90                  95      


Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly 
            100                 105                 110         


Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  116
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG2A hinge sequence

<400>  116

Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala 
1               5                   10                  15      


Arg His Ser Pro 
            20  


<210>  117
<211>  647
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IL6xR complex

<400>  117

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Ile Ala Arg Gly Val Asp Pro Glu Glu Pro Gln Leu Ser Cys 
            20                  25                  30          


Phe Arg Lys Ser Pro Leu Ser Asn Val Val Cys Glu Trp Gly Pro Arg 
        35                  40                  45              


Ser Thr Pro Ser Leu Thr Thr Lys Ala Val Leu Leu Val Arg Lys Phe 
    50                  55                  60                  


Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu Pro Cys Gln Tyr Ser Gln 
65                  70                  75                  80  


Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala Val Pro Glu Gly Asp Ser 
                85                  90                  95      


Ser Phe Tyr Ile Val Ser Met Cys Val Ala Ser Ser Val Gly Ser Lys 
            100                 105                 110         


Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys Gly Ile Leu Gln Pro Asp 
        115                 120                 125             


Pro Pro Ala Asn Ile Thr Val Thr Ala Val Ala Arg Asn Pro Arg Trp 
    130                 135                 140                 


Leu Ser Val Thr Trp Gln Asp Pro His Ser Trp Asn Ser Ser Phe Tyr 
145                 150                 155                 160 


Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala Glu Arg Ser Lys Thr Phe 
                165                 170                 175     


Thr Thr Trp Met Val Lys Asp Leu Gln His His Cys Val Ile His Asp 
            180                 185                 190         


Ala Trp Ser Gly Leu Arg His Val Val Gln Leu Arg Ala Gln Glu Glu 
        195                 200                 205             


Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser Pro Glu Ala Met Gly Thr 
    210                 215                 220                 


Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala Gly Gly Gly Ser Asp Val 
225                 230                 235                 240 


Ala Ala Pro His Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys 
                245                 250                 255     


Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr 
            260                 265                 270         


Cys Asn Lys Ser Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu 
        275                 280                 285             


Asn Asn Leu Asn Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln 
    290                 295                 300                 


Ser Gly Phe Asn Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu 
305                 310                 315                 320 


Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser 
                325                 330                 335     


Ser Glu Glu Gln Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile 
            340                 345                 350         


Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro 
        355                 360                 365             


Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn 
    370                 375                 380                 


Gln Trp Leu Gln Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys 
385                 390                 395                 400 


Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu Arg Gln Met Asp Gln Pro 
                405                 410                 415     


Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro 
            420                 425                 430         


Asn Leu Leu Gly Gly Ser Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
        435                 440                 445             


Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val 
    450                 455                 460                 


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
465                 470                 475                 480 


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
                485                 490                 495     


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
            500                 505                 510         


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu 
        515                 520                 525             


Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg 
    530                 535                 540                 


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys 
545                 550                 555                 560 


Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp 
                565                 570                 575     


Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys 
            580                 585                 590         


Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
        595                 600                 605             


Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser 
    610                 615                 620                 


Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr Lys Ser 
625                 630                 635                 640 


Phe Ser Arg Thr Pro Gly Lys 
                645         


<210>  118
<211>  257
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp 
    


<210>  119
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr 
    210     


<210>  120
<211>  15
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  Wild type human IgG1 hinge

<400>  120

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  121
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CSC-P)

<400>  121

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  122
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CCS-P)

<400>  122

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  123
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human IgG1 hinge (CCS-S)

<400>  123

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  124
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human CH2 upper hinge like sequence of IgE

<400>  124

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Ser Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Ser Ala 
            100                 105         


<210>  125
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  125

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  126
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  126

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  127
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  127

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  128
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  128

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  129
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  129

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15  


<210>  130
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  130

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  131
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  131

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  132
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  132

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  133
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  133

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  134
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  134

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  135
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  135

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  136
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  136

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  137
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  137

Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  138
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  138

Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  139
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  139

Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  140
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  140

Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  141
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  141

Glu Pro Met Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  142
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  142

Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  143
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  143

Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  144
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  144

Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  145
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  145

Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  146
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  146

Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  147
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  147

Glu Pro Met Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  148
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  148

Glu Pro Met Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  149
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  149

Glu Pro Met Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  150
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  150

Glu Pro Met Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  151
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  151

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  152
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  152

Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  153
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  153

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  154
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  154

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  155
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  155

Glu Pro Thr Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  156
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  156

Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  157
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  157

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  158
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  158

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  159
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  159

Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  160
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  160

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  161
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  161

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  162
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  162

Glu Pro Thr Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  163
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  163

Glu Pro Thr Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  164
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  164

Glu Pro Thr Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  165
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  165

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  166
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  166

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  167
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  167

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  168
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  168

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  169
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  169

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  170
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  170

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  171
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  171

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  172
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  172

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  173
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  173

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  174
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  174

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  175
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  175

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  176
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  176

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  177
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  177

Glu Pro Ala Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  178
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  178

Glu Pro Ala Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  179
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  179

Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  180
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  180

Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  181
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  181

Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  


<210>  182
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  182

Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  


<210>  183
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  183

Glu Pro Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  


<210>  184
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  184

Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  


<210>  185
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  185

Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  


<210>  186
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  186

Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  


<210>  187
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  187

Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  


<210>  188
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  188

Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  


<210>  189
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  189

Glu Pro Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  


<210>  190
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  190

Glu Pro Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  


<210>  191
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  191

Glu Pro Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  


<210>  192
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 upper hinge region

<400>  192

Glu Pro Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  


<210>  193
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  193

Asn Ser 
1       


<210>  194
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  194

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  195
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  195

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  196
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  196

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  197
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  197

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  198
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  198

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  199
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  199

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  200
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  200

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  201
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  201

Gly Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   


<210>  202
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  202

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  203
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  203

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  204
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  204

Glu Glu Glu Glu Asp Glu Gly Asn Ser 
1               5                   


<210>  205
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  205

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  206
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  206

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  207
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  207

Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Pro 
1               5                   10      


<210>  208
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  208

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  209
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  209

Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10          


<210>  210
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  210

Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10          


<210>  211
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  211

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  212
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  212

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Cys Pro 
1               5                   10              


<210>  213
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  213

Glu Pro Lys Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro 
1               5                   10              


<210>  214
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  214

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  215
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  215

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  216
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  216

Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  217
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  217

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  218
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  218

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  219
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  219

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  220
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  220

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  221
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  221

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  222
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  222

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  223
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  223

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  224
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  224

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  225
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  225

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  226
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  226

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  227
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  227

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  228
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  228

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  229
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  229

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  230
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  230

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  231
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  231

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  232
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  232

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  233
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  233

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  234
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  234

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  235
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  235

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  236
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  236

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  237
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  237

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  238
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  238

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  239
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  239

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  240
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  240

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  241
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  241

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  242
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  242

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  243
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  243

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  244
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  244

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15  


<210>  245
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  245

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  246
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  246

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  247
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  247

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  248
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  248

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  249
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  249

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  250
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  250

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  251
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  251

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  252
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  252

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  253
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  253

Gly Gly Gly Gly Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  254
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  254

Glu Pro Lys Ser Cys Gly Gly Gly Gly Gly Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  255
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  255

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Gly Gly Cys Pro 
1               5                   10                  15  


<210>  256
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  256

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly 
1               5                   10                  15  


<210>  257
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  257

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  258
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  258

Glu Pro Lys Ser Cys Asp Lys Cys His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  259
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  259

Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  260
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  260

Glu Pro Lys Ser Cys Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  261
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  261

Pro Pro Pro Pro Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  262
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  262

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Trp Trp Cys Pro 
1               5                   10                  15  


<210>  263
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  263

Glu Pro Lys Ser Cys Asp Trp Trp His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  264
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  264

Glu Pro Lys Cys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  265
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  265

Glu Pro Lys Ser Asp Cys Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  266
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  266

Glu Pro Lys Ser Asp Cys Trp Trp His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  267
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  267

Glu Pro Lys Ser Cys Asp Phe Phe His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  268
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  268

Glu Pro Lys Ser Cys Asp Trp Trp Trp Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  269
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  269

Glu Pro Lys Ser Cys Trp Trp Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  270
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  270

Glu Pro Trp Trp Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  271
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  271

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  272
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  272

Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  273
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  273

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  274
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  274

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  275
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  275

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  276
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  276

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  277
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  277

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Gly Gly Gly Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  278
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  278

Glu Pro Lys Ser Cys Asp Gly Gly Gly Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  279
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  279

Glu Pro Lys Ser Cys Asp Pro Pro Pro Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  280
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  280

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Pro Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  281
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  281

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  282
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  282

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Asn Ser 
            


<210>  283
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  283

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  284
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  284

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  285
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  285

Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala 
1               5                   10                  15      


Arg His Ser Pro 
            20  


<210>  286
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  286

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  287
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  287

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  288
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  288

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  289
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  289

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  290
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  290

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  291
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  291

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  292
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  292

Glu Glu Glu Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu 
1               5                   10                  15      


Asp Gly Asn Ser 
            20  


<210>  293
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  293

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  294
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  294

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  295
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  295

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  296
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  296

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  297
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  297

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  298
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  298

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  299
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  299

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Asn Ser 
        35      


<210>  300
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  300

Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg 
1               5                   10                  15      


Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys 
            20                  25                  30          


Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 
        35                  40                  45              


Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 
    50                  55                  60                  


Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 
                85                  90                  95      


Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys 
            100                 105                 110         


Gly Ser Ala Asp Thr Cys Cys Pro Asn Ser 
        115                 120         


<210>  301
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  301

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  302
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  302

Asn Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Asn Ser 
        35                  


<210>  303
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  303

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  304
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  304

Ser Pro Pro Ser Pro Asn Ser 
1               5           


<210>  305
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  305

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  306
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  306

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  307
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  307

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  308
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  308

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  309
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  309

Arg Thr Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
1               5                   10                  15      


Ala Arg His Ser Gly His 
            20          


<210>  310
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  310

Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg 
1               5                   10                  15      


Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys 
            20                  25                  30          


Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 
        35                  40                  45              


Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 
    50                  55                  60                  


Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 
                85                  90                  95      


Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys 
            100                 105                 110         


Gly Ser Ala Asp Thr Cys 
        115             


<210>  311
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  311

Arg Thr Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu Gln Lys Leu 
1               5                   10                  15      


Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys Gly Ser Ala 
            20                  25                  30          


Asp Thr Cys 
        35  


<210>  312
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  312

Arg Thr Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe 
1               5                   10                  15      


Phe Thr Cys Gly Ser Ala Asp Thr Cys 
            20                  25  


<210>  313
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  313

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  314
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  314

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
1               5                   10                  15      


<210>  315
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  315

Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  316
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  316

Gly Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  317
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Anti-mouse CD86 (GL1) scFv linker

<400>  317

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  318
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  FUN1 scFV linker

<400>  318

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  319
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  3D1 scFv linker

<400>  319

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  320
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H68 Linker

<400>  320

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  321
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H69 Linker

<400>  321

Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr 
1               5                   10                  15      


Ser Gly Ser Ala Asp Thr Ser Pro Asn Ser 
            20                  25      


<210>  322
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H77 Linker

<400>  322

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  323
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H78 Linker

<400>  323

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Pro Asn Ser 
1               5                   10                  


<210>  324
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H79 Linker

<400>  324

Asn Ser Leu Phe Asn Gln Glu Val Pro Asn Ser 
1               5                   10      


<210>  325
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H80 Linker

<400>  325

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Pro Asn Ser 
1               5                   10              


<210>  326
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H81 Linker

<400>  326

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  327
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H82 Linker

<400>  327

His Asp Gly Ser Ser Leu Asn Thr Pro Asn Ser 
1               5                   10      


<210>  328
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H83 Linker

<400>  328

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  329
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A2 Hinge

<400>  329

Pro Pro Pro Pro Pro Cys Pro Pro Cys 
1               5                   


<210>  330
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75 Linker

<400>  330

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  331
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75aLinker

<400>  331

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  332
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75b Linker

<400>  332

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  333
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75c Linker

<400>  333

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  334
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75d Linker

<400>  334

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  335
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75e Linker

<400>  335

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  336
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75f Linker

<400>  336

Gln Arg His Ala Asn Ser Ala Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  337
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75g Linker

<400>  337

Gln Arg His Asn Ala Ala Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  338
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H75h Linker

<400>  338

Gln Arg His Ala Ala Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  339
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H68a Linker

<400>  339

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  340
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H68b Linker

<400>  340

Asn Ser Gly Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  341
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H68c Linker

<400>  341

Asn Ser Gly Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  342
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H68s Linker

<400>  342

Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  15      


<210>  343
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable Region Linker Subunit

<400>  343

Gly Gly Gly Gly Ser 
1               5   


<210>  344
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  monoIL10 Linker

<400>  344

Gly Gly Gly Ser Gly Gly 
1               5       


<210>  345
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  345

Glu Pro Lys Ser Cys Asp Lys Thr His Thr 
1               5                   10  


<210>  346
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  346

Glu Arg Lys Cys Cys Val Glu 
1               5           


<210>  347
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  347

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr 
1               5                   10          


<210>  348
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  348

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro 
1               5                   10  


<210>  349
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  349

Glu Ser Lys Tyr Gly Pro Pro 
1               5           


<210>  350
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  350

Cys Pro Arg Cys Pro 
1               5   


<210>  351
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  351

Cys Pro Ser Cys Pro 
1               5   


<210>  352
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  352

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro 
    


<210>  353
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  353

Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
1               5                   10                  15  


<210>  354
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  354

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr 
        


<210>  355
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  355

Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu Glu Gln 
1               5                   10                  15      


Glu Glu Arg Glu Thr Lys Thr Pro 
            20                  


<210>  356
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  356

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  357
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  357

Val Pro Pro Pro Pro Pro 
1               5       


<210>  358
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  358

Val Cys Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser 
1               5                   10                  15      


Ser Ser Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys 
            20                  25                  30          


Leu Val Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu 
        35                  40                  45              


Asp Gly Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln 
    50                  55                  60                  


Glu Gly Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys 
65                  70                  75                  80  


His Trp Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly 
                85                  90                  95      


His Thr Phe Glu Asp Ser Thr Lys Lys Cys Ala 
            100                 105         


<210>  359
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  359

Val Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg 
1               5                   10                  15      


Asp Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala 
            20                  25                  30          


Thr Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly 
        35                  40                  45              


Lys Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala 
    50                  55                  60                  


Lys Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile 
65                  70                  75                  80  


Lys Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp 
                85                  90                  95      


His Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Cys Val Pro 
            100                 105                 110         


<210>  360
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  360

Cys Pro Pro Cys Pro 
1               5   


<210>  361
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable domain linker

<400>  361

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  362
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variable domain linker

<400>  362

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  363
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  wild type human IgG1

<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  wild type human IgG1 CH1 region

<400>  363

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Lys Val 
        


<210>  364
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(102)
<223>  Wild type human IgG2

<220>
<221>  MISC_FEATURE
<222>  (1)..(102)
<223>  Wild type human IgG2 CH1 region

<400>  364

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Cys Ser Thr 
1               5                   10                  15      


Gln Pro Asp Gly Asn Val Val Ile Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Gly Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Leu Ala Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro 
            100         


<210>  365
<211>  102
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(102)
<223>  Wild type human IgG3

<220>
<221>  MISC_FEATURE
<222>  (1)..(102)
<223>  Wild type human IgG3 CH1 region

<400>  365

Ala Ser Pro Thr Ser Pro Lys Val Phe Pro Leu Ser Leu Asp Ser Thr 
1               5                   10                  15      


Pro Gln Asp Gly Asn Val Val Val Ala Cys Leu Val Gln Gly Phe Phe 
            20                  25                  30          


Pro Gln Glu Pro Leu Ser Val Thr Trp Ser Glu Ser Gly Gln Asn Val 
        35                  40                  45              


Thr Ala Arg Asn Phe Pro Pro Ser Gln Asp Ala Ser Gly Asp Leu Tyr 
    50                  55                  60                  


Thr Thr Ser Ser Gln Leu Thr Leu Pro Ala Thr Gln Cys Pro Asp Gly 
65                  70                  75                  80  


Lys Ser Val Thr Cys His Val Lys His Tyr Thr Asn Pro Ser Gln Asp 
                85                  90                  95      


Val Thr Val Pro Cys Pro 
            100         


<210>  366
<211>  101
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Wild type human IgG4

<220>
<221>  MISC_FEATURE
<222>  (1)..(101)
<223>  Wild type human IgG4 CH1 region

<400>  366

Ala Pro Thr Lys Ala Pro Asp Val Phe Pro Ile Ile Ser Gly Cys Arg 
1               5                   10                  15      


His Pro Lys Asp Asn Ser Pro Val Val Leu Ala Cys Leu Ile Thr Gly 
            20                  25                  30          


Tyr His Pro Thr Ser Val Thr Val Thr Trp Tyr Met Gly Thr Gln Ser 
        35                  40                  45              


Gln Pro Gln Arg Thr Phe Pro Glu Ile Gln Arg Arg Asp Ser Tyr Tyr 
    50                  55                  60                  


Met Thr Ser Ser Gln Leu Ser Thr Pro Leu Gln Gln Trp Arg Gln Gly 
65                  70                  75                  80  


Glu Tyr Lys Cys Val Val Gln His Thr Ala Ser Lys Ser Lys Lys Glu 
                85                  90                  95      


Ile Phe Arg Trp Pro 
            100     


<210>  367
<211>  103
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  Wild type human IgA1

<220>
<221>  MISC_FEATURE
<222>  (1)..(103)
<223>  Wild type human IgA1 CH1 region

<400>  367

Ala Ser Thr Gln Ser Pro Ser Val Phe Pro Leu Thr Arg Cys Cys Lys 
1               5                   10                  15      


Asn Ile Pro Ser Asn Ala Thr Ser Val Thr Leu Gly Cys Leu Ala Thr 
            20                  25                  30          


Gly Tyr Phe Pro Glu Pro Val Met Val Thr Cys Asp Thr Gly Ser Leu 
        35                  40                  45              


Asn Gly Thr Thr Met Thr Leu Pro Ala Thr Thr Leu Thr Leu Ser Gly 
    50                  55                  60                  


His Tyr Ala Thr Ile Ser Leu Leu Thr Val Ser Gly Ala Trp Ala Lys 
65                  70                  75                  80  


Gln Met Phe Thr Cys Arg Val Ala His Thr Pro Ser Ser Thr Asp Trp 
                85                  90                  95      


Val Asp Asn Lys Thr Phe Ser 
            100             


<210>  368
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human IgA2

<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human IgA2 CH1 region

<400>  368

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Thr Val 
        


<210>  369
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human IgD

<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human IgD CH1 region

<400>  369

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  370
<211>  98
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human IgE

<220>
<221>  MISC_FEATURE
<222>  (1)..(98)
<223>  Wild type human IgE CH1 region

<400>  370

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg 
1               5                   10                  15      


Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr 
65                  70                  75                  80  


Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  371
<211>  104
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(104)
<223>  Wild type human IgM CH1 region

<400>  371

Gly Ser Ala Ser Ala Pro Thr Leu Phe Pro Leu Val Ser Cys Glu Asn 
1               5                   10                  15      


Ser Pro Ser Asp Thr Ser Ser Val Ala Val Gly Cys Leu Ala Gln Asp 
            20                  25                  30          


Phe Leu Pro Asp Ser Ile Thr Leu Ser Trp Lys Tyr Lys Asn Asn Ser 
        35                  40                  45              


Asp Ile Ser Ser Thr Arg Gly Phe Pro Ser Val Leu Arg Gly Gly Lys 
    50                  55                  60                  


Tyr Ala Ala Thr Ser Gln Val Leu Leu Pro Ser Lys Asp Val Met Gln 
65                  70                  75                  80  


Gly Thr Asp Glu His Val Val Cys Lys Val Gln His Pro Asn Gly Asn 
                85                  90                  95      


Lys Glu Lys Asn Val Pro Leu Pro 
            100                 


<210>  372
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human Ckappa

<400>  372

Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
1               5                   10                  15      


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
            20                  25                  30          


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
        35                  40                  45              


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
    50                  55                  60                  


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
65                  70                  75                  80  


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
                85                  90                  95      


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
            100                 105         


<210>  373
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human Clambda

<400>  373

Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser 
1               5                   10                  15      


Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp 
            20                  25                  30          


Phe Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro 
        35                  40                  45              


Val Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn 
    50                  55                  60                  


Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys 
65                  70                  75                  80  


Ser His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val 
                85                  90                  95      


Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
            100                 105     


<210>  374
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  374

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  375
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human C-lambda sequence

<400>  375

Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Pro Pro Ser Ser Glu 
1               5                   10                  15      


Glu Leu Gln Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe 
            20                  25                  30          


Tyr Pro Gly Ala Val Thr Val Ala Trp Lys Ala Asp Gly Ser Pro Val 
        35                  40                  45              


Lys Ala Gly Val Glu Thr Thr Lys Pro Ser Lys Gln Ser Asn Asn Lys 
    50                  55                  60                  


Tyr Ala Ala Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser 
65                  70                  75                  80  


His Arg Ser Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu 
                85                  90                  95      


Lys Thr Val Ala Pro Thr Glu Ser Ser 
            100                 105 


<210>  376
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29A substitution

<400>  376

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  377
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30A substitution

<400>  377

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  378
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with Q52A substitution

<400>  378

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Ala Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  379
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A substitution

<400>  379

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  380
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with T56A substitution

<400>  380

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Ala Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  381
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with S68A substitution

<400>  381

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  382
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with T70A substitution

<400>  382

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  383
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A N29A substitution

<400>  383

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  384
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A N30A substitution

<400>  384

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  385
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A Q52A substitution

<400>  385

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Ala Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  386
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A S68A substitution

<400>  386

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  387
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A T70A substitution

<400>  387

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  388
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A N29A N30A substitution

<400>  388

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  389
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A N29A S68A substitution

<400>  389

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  390
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A S68A T70A substitution

<400>  390

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ala Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  391
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55A Q52A S68A substitution

<400>  391

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Ala Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ala Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  392
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29R V55A T70A substitution

<400>  392

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Arg Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  393
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29AK V55A T70A substitution

<400>  393

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Lys Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  394
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29W V55A T70A substitution

<400>  394

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  395
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29Y V55A T70A substitution

<400>  395

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  396
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with S68K V55A substitution

<400>  396

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Lys Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  397
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with S68E V55A substitution

<400>  397

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Glu Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  398
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with S68Q V55A substitution

<400>  398

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Gln Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  399
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with T70E V55A substitution

<400>  399

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  400
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with Q52L N29A N30A substitution

<400>  400

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Leu Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  401
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30R V55A T70A substitution

<400>  401

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Arg Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  402
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30K V55A T70A substitution

<400>  402

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Lys Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  403
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30W V55A T70A substitution

<400>  403

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Trp Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  404
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30E V55A T70A substitution

<400>  404

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  405
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30G V55A T70A substitution

<400>  405

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Gly Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  406
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55R N29A N30A substitution

<400>  406

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Arg Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  407
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55W N29A N30A substitution

<400>  407

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Trp Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  408
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55E N29A N30A substitution

<400>  408

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Glu Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  409
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29W V55A T70E (WYAE) substitution

<400>  409

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Tyr Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  410
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29Y N30Y V55A T70E (YYAE) substitution

<400>  410

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Tyr Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  411
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30E V55A T70E (EAE) substitution

<400>  411

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  412
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30Y V55A T70A (YAE) substitution

<400>  412

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  413
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Interceptor Ck variant 1 (YAE)

<400>  413

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Tyr Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  414
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Interceptor Ck variant 2 (EAE)

<400>  414

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  415
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29W V55A T70A substitution

<400>  415

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  416
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29Y V55A T70A substitution

<400>  416

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Asn Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  417
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with T70E N29A N30A V55A substitution

<400>  417

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  418
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30R V55A T70A substitution

<400>  418

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Arg Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  419
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30K V55A T70A substitution

<400>  419

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Lys Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  420
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N30E V55A T70A substitution

<400>  420

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Glu Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Ala Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  421
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with V55R N29A N30A substitution

<400>  421

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Ala Ala Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Arg Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  422
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29W N30Y V55A T70E (WYAE) substitution

<400>  422

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Trp Tyr Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  423
<211>  105
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered human Ck with N29Y N30Y V55A T70E (YYAE) substitution

<400>  423

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
1               5                   10                  15      


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Tyr Tyr Phe Tyr 
            20                  25                  30          


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
        35                  40                  45              


Gly Asn Ser Gln Glu Ser Ala Thr Glu Gln Asp Ser Lys Asp Ser Thr 
    50                  55                  60                  


Tyr Ser Leu Ser Ser Glu Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
65                  70                  75                  80  


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
                85                  90                  95      


Val Thr Lys Ser Phe Asn Arg Gly Glu 
            100                 105 


<210>  424
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered IgG1 CH2 domian N297A

<400>  424

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  425
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse IGHG2c mutated CH2 (alanine substitutions at positions 
       L234, L235, G237, E318, K320 and K322)

<400>  425

Ala Pro Asp Ala Ala Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Ala Phe Ala Cys Ala Val Asn Asn Arg 
                85                  90                  95      


Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg 
            100                 105                 110 


<210>  426
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2 region with alanine substitutions at L234, L235, 
       G237 and N297 and a deletion at G236

<400>  426

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 


<210>  427
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG2 CH2 region with alanine substitutions at V234, G236, 
       and N297

<400>  427

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Ala Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr 
            100                 105             


<210>  428
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 CH2 region with alanine substitutions at F234, L235, 
       G237 and N297 and a deletion of G236

<400>  428

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 


<210>  429
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 CH2 region with alanine substitutions at F234 and N297

<400>  429

Ala Pro Glu Ala Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  430
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 CH2 region with alanine substitutions at L235 and N297

<400>  430

Ala Pro Glu Phe Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  431
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  human IgG4 CH2 region with alanine substitutions at G236 and N297

<400>  431

Ala Pro Glu Phe Leu Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  432
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG4 CH2 region with alanine substitutions at G237 and N297

<400>  432

Ala Pro Glu Phe Leu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  433
<211>  110
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  IgG2a CH2

<400>  433

Ala Pro Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
1               5                   10                  15      


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
        35                  40                  45              


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
    50                  55                  60                  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
65                  70                  75                  80  


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg 
                85                  90                  95      


Ala Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg 
            100                 105                 110 


<210>  434
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2 with L235A, E318A, K320A and K322A substitutions

<400>  434

Ala Pro Glu Leu Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  435
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2 with L234A, L235A, G237A, E318A, K320A and K322A

<400>  435

Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  436
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human IgG1 CH3 domain

<400>  436

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  437
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type IgG2 human CH3 domain

<400>  437

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  438
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type IgG3 human CH3 domain

<400>  438

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Ile Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  439
<211>  107
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(107)
<223>  Wild type human IgG4 CH3 domain

<400>  439

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
            100                 105         


<210>  440
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Wild type human IgA1 CH3 domain

<400>  440

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  441
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Wild type human IgA2 CH3 domain

<400>  441

Gly Asn Thr Phe Arg Pro Glu Val His Leu Leu Pro Pro Pro Ser Glu 
1               5                   10                  15      


Glu Leu Ala Leu Asn Glu Leu Val Thr Leu Thr Cys Leu Ala Arg Gly 
            20                  25                  30          


Phe Ser Pro Lys Asp Val Leu Val Arg Trp Leu Gln Gly Ser Gln Glu 
        35                  40                  45              


Leu Pro Arg Glu Lys Tyr Leu Thr Trp Ala Ser Arg Gln Glu Pro Ser 
    50                  55                  60                  


Gln Gly Thr Thr Thr Phe Ala Val Thr Ser Ile Leu Arg Val Ala Ala 
65                  70                  75                  80  


Glu Asp Trp Lys Lys Gly Asp Thr Phe Ser Cys Met Val Gly His Glu 
                85                  90                  95      


Ala Leu Pro Leu Ala Phe Thr Gln Lys Thr Ile Asp Arg Leu Ala Gly 
            100                 105                 110         


Lys Pro Thr His Val Asn Val Ser Val Val Met Ala Glu Val Asp Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  442
<211>  117
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(117)
<223>  Wild type human IgD CH3 domain

<400>  442

Ala Ala Gln Ala Pro Val Lys Leu Ser Leu Asn Leu Leu Ala Ser Ser 
1               5                   10                  15      


Asp Pro Pro Glu Ala Ala Ser Trp Leu Leu Cys Glu Val Ser Gly Phe 
            20                  25                  30          


Ser Pro Pro Asn Ile Leu Leu Met Trp Leu Glu Asp Gln Arg Glu Val 
        35                  40                  45              


Asn Thr Ser Gly Phe Ala Pro Ala Arg Pro Pro Pro Gln Pro Arg Ser 
    50                  55                  60                  


Thr Thr Phe Trp Ala Trp Ser Val Leu Arg Val Pro Ala Pro Pro Ser 
65                  70                  75                  80  


Pro Gln Pro Ala Thr Tyr Thr Cys Val Val Ser His Glu Asp Ser Arg 
                85                  90                  95      


Thr Leu Leu Asn Ala Ser Arg Ser Leu Glu Val Ser Tyr Val Thr Asp 
            100                 105                 110         


His Gly Pro Met Lys 
        115         


<210>  443
<211>  108
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(108)
<223>  Wild type human IgE CH3 domain

<400>  443

Asp Ser Asn Pro Arg Gly Val Ser Ala Tyr Leu Ser Arg Pro Ser Pro 
1               5                   10                  15      


Phe Asp Leu Phe Ile Arg Lys Ser Pro Thr Ile Thr Cys Leu Val Val 
            20                  25                  30          


Asp Leu Ala Pro Ser Lys Gly Thr Val Asn Leu Thr Trp Ser Arg Ala 
        35                  40                  45              


Ser Gly Lys Pro Val Asn His Ser Thr Arg Lys Glu Glu Lys Gln Arg 
    50                  55                  60                  


Asn Gly Thr Leu Thr Val Thr Ser Thr Leu Pro Val Gly Thr Arg Asp 
65                  70                  75                  80  


Trp Ile Glu Gly Glu Thr Tyr Gln Cys Arg Val Thr His Pro His Leu 
                85                  90                  95      


Pro Arg Ala Leu Met Arg Ser Thr Thr Lys Thr Ser 
            100                 105             


<210>  444
<211>  106
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Wild type human IgM CH3 domain

<400>  444

Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
            20                  25                  30          


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
        35                  40                  45              


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
    50                  55                  60                  


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
65                  70                  75                  80  


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
                85                  90                  95      


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys 
            100                 105     


<210>  445

<400>  445
000

<210>  446
<211>  106
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered CH3 region


<220>
<221>  MISC_FEATURE
<222>  (1)..(106)
<223>  Human IgG1 CH3 domain with last lysine deleted

<400>  446

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
            100                 105     


<210>  447
<211>  110
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(110)
<223>  Wild type human IgE CH4 domain

<400>  447

Gly Pro Arg Ala Ala Pro Glu Val Tyr Ala Phe Ala Thr Pro Glu Trp 
1               5                   10                  15      


Pro Gly Ser Arg Asp Lys Arg Thr Leu Ala Cys Leu Ile Gln Asn Phe 
            20                  25                  30          


Met Pro Glu Asp Ile Ser Val Gln Trp Leu His Asn Glu Val Gln Leu 
        35                  40                  45              


Pro Asp Ala Arg His Ser Thr Thr Gln Pro Arg Lys Thr Lys Gly Ser 
    50                  55                  60                  


Gly Phe Phe Val Phe Ser Arg Leu Glu Val Thr Arg Ala Glu Trp Glu 
65                  70                  75                  80  


Gln Lys Asp Glu Phe Ile Cys Arg Ala Val His Glu Ala Ala Ser Pro 
                85                  90                  95      


Ser Gln Thr Val Gln Arg Ala Val Ser Val Asn Pro Gly Lys 
            100                 105                 110 


<210>  448
<211>  131
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(131)
<223>  Wild type human IgM CH4 domain

<400>  448

Gly Val Ala Leu His Arg Pro Asp Val Tyr Leu Leu Pro Pro Ala Arg 
1               5                   10                  15      


Glu Gln Leu Asn Leu Arg Glu Ser Ala Thr Ile Thr Cys Leu Val Thr 
            20                  25                  30          


Gly Phe Ser Pro Ala Asp Val Phe Val Gln Trp Met Gln Arg Gly Gln 
        35                  40                  45              


Pro Leu Ser Pro Glu Lys Tyr Val Thr Ser Ala Pro Met Pro Glu Pro 
    50                  55                  60                  


Gln Ala Pro Gly Arg Tyr Phe Ala His Ser Ile Leu Thr Val Ser Glu 
65                  70                  75                  80  


Glu Glu Trp Asn Thr Gly Glu Thr Tyr Thr Cys Val Val Ala His Glu 
                85                  90                  95      


Ala Leu Pro Asn Arg Val Thr Glu Arg Thr Val Asp Lys Ser Thr Gly 
            100                 105                 110         


Lys Pro Thr Leu Tyr Asn Val Ser Leu Val Met Ser Asp Thr Ala Gly 
        115                 120                 125             


Thr Cys Tyr 
    130     


<210>  449
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  449

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  450
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  450

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  451
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G1 N297A  CH2-CH3 (N297ST - A297ST)

<400>  451

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  452
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 AA N297A CH2CH3 (Ala substitutions at 234, 235, 237 and 297;
       236 deleted)

<400>  452

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Tyr Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  453
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G2 AA N297A CH2CH3 (Ala substitution at 234, 236 and 297)

<400>  453

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Met Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Ala Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  454
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  G4 AA N297A CH2CH3 (Ala substitutions at 234, 235, 237 and 297; 
       236 deleted)

<400>  454

Ala Pro Glu Ala Ala Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
1               5                   10                  15      


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val 
        35                  40                  45              


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    50                  55                  60                  


Phe Ala Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
65                  70                  75                  80  


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly 
                85                  90                  95      


Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            100                 105                 110         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr 
        115                 120                 125             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    130                 135                 140                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
145                 150                 155                 160 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                165                 170                 175     


Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe 
            180                 185                 190         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        195                 200                 205             


Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215     


<210>  455
<211>  153
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  DeltaCH2 (g1CH3 only)

<400>  455

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Thr Gly Leu Asn Asp 
            100                 105                 110         


Ile Phe Glu Ala Gln Lys Ile Glu Trp His Glu Asp Tyr Lys Asp Asp 
        115                 120                 125             


Asp Asp Lys Asp Tyr Lys Asp Asp Asp Asp Lys Asp Tyr Lys Asp Asp 
    130                 135                 140                 


Asp Asp Lys His His His His His His 
145                 150             


<210>  456
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HM1 (IgM CH3:IgG1 CH3) without C-terminal tail

<400>  456

Asp Gln Asp Thr Ala Ile Arg Val Phe Ala Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Ser Ile Phe Leu Thr Lys Ser Thr Lys Leu Thr Cys Leu Val Thr Asp 
            20                  25                  30          


Leu Thr Thr Tyr Asp Ser Val Thr Ile Ser Trp Thr Arg Gln Asn Gly 
        35                  40                  45              


Glu Ala Val Lys Thr His Thr Asn Ile Ser Glu Ser His Pro Asn Ala 
    50                  55                  60                  


Thr Phe Ser Ala Val Gly Glu Ala Ser Ile Cys Glu Asp Asp Trp Asn 
65                  70                  75                  80  


Ser Gly Glu Arg Phe Thr Cys Thr Val Thr His Thr Asp Leu Pro Ser 
                85                  90                  95      


Pro Leu Lys Gln Thr Ile Ser Arg Pro Lys Gly Gln Pro Arg Glu Pro 
            100                 105                 110         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln 
        115                 120                 125             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    130                 135                 140                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
145                 150                 155                 160 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                165                 170                 175     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            180                 185                 190         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        195                 200                 205             


Leu Ser Pro Gly Lys 
    210             


<210>  457
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 CH2 CH3 Null2

<400>  457

Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215         


<210>  458
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Half null CH2-CH3 regions

<400>  458

Pro Asp Ala Ala Gly Ala Pro Ser Val Phe Ile Phe Pro Pro Lys Ile 
1               5                   10                  15      


Lys Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val 
            20                  25                  30          


Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val 
        35                  40                  45              


Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp 
    50                  55                  60                  


Tyr Ala Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln 
65                  70                  75                  80  


Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala 
                85                  90                  95      


Leu Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val 
            100                 105                 110         


Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr 
        115                 120                 125             


Lys Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala 
    130                 135                 140                 


Glu Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr 
145                 150                 155                 160 


Lys Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr 
                165                 170                 175     


Ser Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe 
            180                 185                 190         


Ala Cys Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys 
        195                 200                 205             


Thr Ile Ser Arg Ser Leu Gly Lys 
    210                 215     


<210>  459
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  HM2 (mouse CH3mu-CH3gamma) without C-termial tail

<400>  459

Ser Pro Ser Thr Asp Ile Leu Thr Phe Thr Ile Pro Pro Ser Phe Ala 
1               5                   10                  15      


Asp Ile Phe Leu Ser Lys Ser Ala Asn Leu Thr Cys Leu Val Ser Asn 
            20                  25                  30          


Leu Ala Thr Tyr Glu Thr Leu Asn Ile Ser Trp Ala Ser Gln Ser Gly 
        35                  40                  45              


Glu Pro Leu Glu Thr Lys Ile Lys Ile Met Glu Ser His Pro Asn Gly 
    50                  55                  60                  


Thr Phe Ser Ala Lys Gly Val Ala Ser Val Cys Val Glu Asp Trp Asn 
65                  70                  75                  80  


Asn Arg Lys Glu Phe Val Cys Thr Val Thr His Arg Asp Leu Pro Ser 
                85                  90                  95      


Pro Gln Lys Lys Phe Ile Ser Lys Pro Asn Gly Pro Val Arg Ala Pro 
            100                 105                 110         


Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys Glu 
        115                 120                 125             


Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile Ala 
    130                 135                 140                 


Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn Thr 
145                 150                 155                 160 


Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu 
                165                 170                 175     


Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys Ser 
            180                 185                 190         


Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile Ser 
        195                 200                 205             


Arg Ser Leu Gly Lys 
    210             


<210>  460
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1 CH2 CH3 Null2 desLys

<400>  460

Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            100                 105                 110         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        115                 120                 125             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    130                 135                 140                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
145                 150                 155                 160 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                165                 170                 175     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            180                 185                 190         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        195                 200                 205             


Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215     


<210>  461
<211>  19
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(19)
<223>  Immunoglobulin hinge region

<400>  461

Val Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro 
1               5                   10                  15      


Ser Pro Ser 
            


<210>  462
<211>  6
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  Immunoglobulin hinge region

<400>  462

Val Pro Pro Pro Pro Pro 
1               5       


<210>  463
<211>  58
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(58)
<223>  Immunoglobulin hinge region

<400>  463

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Gly Arg Gly Gly Glu Glu Lys Lys Lys Glu Lys Glu Lys Glu 
        35                  40                  45              


Glu Gln Glu Glu Arg Glu Thr Lys Thr Pro 
    50                  55              


<210>  464
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Immunoglobulin hinge region

<400>  464

Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro 
1               5                   10          


<210>  465
<211>  62
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(62)
<223>  Immunoglobulin hinge region

<400>  465

Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys Pro Arg Cys 
1               5                   10                  15      


Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
            20                  25                  30          


Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro Glu 
        35                  40                  45              


Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys Pro 
    50                  55                  60          


<210>  466
<211>  12
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  Immunoglobulin hinge region

<400>  466

Glu Ser Lys Tyr Gly Pro Pro Cys Pro Ser Cys Pro 
1               5                   10          


<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  485

Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro 
1               5                   10  


<210>  486
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  486

Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  487
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  487

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  488
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  488

Glu Pro Lys Ser Ser Asp Thr Pro Pro Pro Ser Pro Arg Ser Pro Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


<210>  489
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  489

Pro Ser Thr Pro Pro Thr Pro Ser Pro Ser Thr Pro Pro Thr Pro Ser 
1               5                   10                  15      


Pro Ser Cys Pro Pro Cys Pro 
            20              


<210>  490
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  490

Arg Thr Glu Pro Arg Val Pro Ile Thr Gln Asn Pro Cys Pro Pro Leu 
1               5                   10                  15      


Lys Glu Cys Pro Pro Cys Ala 
            20              


<210>  491
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  491

Glu Ser Pro Lys Ala Gln Ala Ser Ser Val Pro Thr Ala Gln Pro Gln 
1               5                   10                  15      


Ala Glu Gly Ser Leu Ala Lys Ala Thr Thr Ala Pro Ala Thr Thr Arg 
            20                  25                  30          


Asn Thr Cys Pro Pro Cys Pro 
        35                  


<210>  492
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  492

Gln Glu Lys Glu Ala Ile Glu Arg Leu Lys Ala Ala Gly Ala Pro Glu 
1               5                   10                  15      


Ser Leu Val Ile Gln Ala Tyr Phe Ala Ser Glu Lys Asn Glu Asn Leu 
            20                  25                  30          


Ala Ala Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu Cys Pro Pro 
        35                  40                  45              


Cys Pro 
    50  


<210>  493
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  493

Gln Glu Lys Glu Ala Ile Glu Arg Leu Lys Ala Ala Gly Ala Pro Glu 
1               5                   10                  15      


Ser Leu Val Ile Gln Ala Tyr Phe Ala Ser Glu Lys Asn Glu Asn Leu 
            20                  25                  30          


Ala Ala Asn Phe Leu Leu Ser Gln Asn Phe Asp Asp Glu Cys Pro Pro 
        35                  40                  45              


Cys Pro Ser Gly 
    50          


<210>  494
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  494

Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Ser 
1               5                   10                  15      


Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val 
            20                  25                  30          


Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly 
        35                  40                  45              


Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly 
    50                  55                  60                  


Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp 
65                  70                  75                  80  


Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr 
                85                  90                  95      


Phe Glu Asp Ser Thr Lys Lys Ser Ala Cys Pro Pro Cys Pro 
            100                 105                 110 


<210>  495
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Altered immunoglobulin hinge

<400>  495

Ser Arg Asp Phe Thr Pro Pro Thr Val Lys Ile Leu Gln Ser Ser Ser 
1               5                   10                  15      


Asp Gly Gly Gly His Phe Pro Pro Thr Ile Gln Leu Leu Cys Leu Val 
            20                  25                  30          


Ser Gly Tyr Thr Pro Gly Thr Ile Asn Ile Thr Trp Leu Glu Asp Gly 
        35                  40                  45              


Gln Val Met Asp Val Asp Leu Ser Thr Ala Ser Thr Thr Gln Glu Gly 
    50                  55                  60                  


Glu Leu Ala Ser Thr Gln Ser Glu Leu Thr Leu Ser Gln Lys His Trp 
65                  70                  75                  80  


Leu Ser Asp Arg Thr Tyr Thr Cys Gln Val Thr Tyr Gln Gly His Thr 
                85                  90                  95      


Phe Glu Asp Ser Thr Lys Lys Ser Ala Cys Pro Pro Cys Ser Gly 
            100                 105                 110     


<210>  496
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stalk  region of CD69

<400>  496

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met 
1               5                   10          


<210>  497
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stalk  region of CD72

<400>  497

Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys 
1               5                   10      


<210>  498
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stalk  region of CD94

<400>  498

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys 
        


<210>  499
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Stalk  region of NKG2A

<400>  499

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys 
        


<210>  500
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Made in a lab

<400>  500

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  501
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D Linker

<400>  501

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser 
    


<210>  502
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  H68 linker (scorpion linker derived from NKG2D)

<400>  502

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  503
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  503

Arg Thr Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
1               5                   10                  15      


Ala Arg His Ser Gly His 
            20          


<210>  504
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  504

Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg 
1               5                   10                  15      


Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys 
            20                  25                  30          


Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 
        35                  40                  45              


Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 
    50                  55                  60                  


Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 
                85                  90                  95      


Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys 
            100                 105                 110         


Gly Ser Ala Asp Thr Cys 
        115             


<210>  505
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  505

Arg Thr Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu Gln Lys Leu 
1               5                   10                  15      


Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys Gly Ser Ala 
            20                  25                  30          


Asp Thr Cys 
        35  


<210>  506
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  506

Arg Thr Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe 
1               5                   10                  15      


Phe Thr Cys Gly Ser Ala Asp Thr Cys 
            20                  25  


<210>  507
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  507

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  508
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  508

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  509
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  509

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  510
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  510

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  511
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  511

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  512
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  512

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  513
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  513

Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  15      


<210>  514
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  514

Asn Ser Gly Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  515
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  515

Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr Ser Pro Asn Ser 
1               5                   10                  


<210>  516
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  516

Asn Ser Gly Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  517
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  517

Asn Ser Leu Ala Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  518
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  518

Asn Ser Leu Phe Ser Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  519
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  519

Asn Ser Leu Ala Ser Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  520
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  520

Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr 
1               5                   10                  15      


Ser Gly Ser Ala Asp Thr Ser Pro Asn Ser 
            20                  25      


<210>  521
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  521

Gln Arg His Ala Asn Ser Ala Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  522
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  522

Gln Arg His Asn Ala Ala Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  523
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  523

Gln Arg His Ala Ala Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  524
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  524

Gln Arg His Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  525
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  525

Gln Arg His Gly Gly Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  526
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  526

His Asp Gly Ser Ser Leu Asn Thr Pro Asn Ser 
1               5                   10      


<210>  527
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  527

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  528
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  528

Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  529
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  529

Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Arg His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  530
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  530

Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  531
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  531

Ser Ser Leu Asn Thr Gly Thr Gln Lys Ala Arg His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  532
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  532

Ser Ser Leu Asn Thr Arg Thr Gln Met Ala Arg His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  533
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  533

Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  534
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  534

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  535
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  535

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Pro Asn Ser 
1               5                   10                  


<210>  536
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  536

Asn Ser Leu Phe Asn Gln Glu Val Pro Asn Ser 
1               5                   10      


<210>  537
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  537

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Pro Asn Ser 
1               5                   10              


<210>  538

<400>  538
000

<210>  539

<400>  539
000

<210>  540

<400>  540
000

<210>  541

<400>  541
000

<210>  542

<400>  542
000

<210>  543

<400>  543
000

<210>  544

<400>  544
000

<210>  545

<400>  545
000

<210>  546

<400>  546
000

<210>  547

<400>  547
000

<210>  548

<400>  548
000

<210>  549

<400>  549
000

<210>  550

<400>  550
000

<210>  551

<400>  551
000

<210>  552

<400>  552
000

<210>  553

<400>  553
000

<210>  554

<400>  554
000

<210>  555

<400>  555
000

<210>  556

<400>  556
000

<210>  557

<400>  557
000

<210>  558

<400>  558
000

<210>  559

<400>  559
000

<210>  560

<400>  560
000

<210>  561

<400>  561
000

<210>  562

<400>  562
000

<210>  563

<400>  563
000

<210>  564

<400>  564
000

<210>  565

<400>  565
000

<210>  566

<400>  566
000

<210>  567

<400>  567
000

<210>  568

<400>  568
000

<210>  569

<400>  569
000

<210>  570

<400>  570
000

<210>  571

<400>  571
000

<210>  572

<400>  572
000

<210>  573

<400>  573
000

<210>  574

<400>  574
000

<210>  575

<400>  575
000

<210>  576

<400>  576
000

<210>  577

<400>  577
000

<210>  578

<400>  578
000

<210>  579

<400>  579
000

<210>  580

<400>  580
000

<210>  581

<400>  581
000

<210>  582

<400>  582
000

<210>  583

<400>  583
000

<210>  584

<400>  584
000

<210>  585

<400>  585
000

<210>  586

<400>  586
000

<210>  587

<400>  587
000

<210>  588

<400>  588
000

<210>  589

<400>  589
000

<210>  590

<400>  590
000

<210>  591

<400>  591
000

<210>  592

<400>  592
000

<210>  593

<400>  593
000

<210>  594
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  immunoglobulin hinge core structure

<400>  594

Cys Pro Pro Cys 
1               


<210>  595
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  595

Asn Ser 
1       


<210>  596
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  596

Ser Cys Pro Pro Cys Pro 
1               5       


<210>  597
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  597

Gly Gly Gly Gly Ser Gly Asn Ser 
1               5               


<210>  598
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  598

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  599
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  599

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  600
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  600

Gly Ser Pro Pro Ser Pro Asn Ser 
1               5               


<210>  601
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  601

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  602
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  602

Gly Cys Pro Pro Cys Pro Asn Ser 
1               5               


<210>  603
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  603

Gly Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   


<210>  604
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  604

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  605
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  605

Gly Cys Pro Pro Cys Pro Ala Asn Ser 
1               5                   


<210>  606
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  606

Glu Glu Glu Glu Asp Glu Gly Asn Ser 
1               5                   


<210>  607
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  607

Asn Tyr Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10  


<210>  608
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  608

Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10  


<210>  609
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  609

Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Pro 
1               5                   10      


<210>  610
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  610

Ser Gln Pro Glu Ile Val Pro Ile Ser Asn Ser 
1               5                   10      


<210>  611
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  611

Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10          


<210>  612
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  612

Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10          


<210>  613
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  613

Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10          


<210>  614
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  614

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Cys Pro 
1               5                   10              


<210>  615
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  615

Glu Pro Lys Ser Cys Asp Lys Thr Cys Pro Pro Cys Pro 
1               5                   10              


<210>  616
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  616

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10              


<210>  617
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  617

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  618
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  618

Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  619
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  619

Gly Cys Pro Pro Cys Pro Gly Gly Gly Gly Ser Asn Ser 
1               5                   10              


<210>  620
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  620

Gly Gly Gly Ala Ser Cys Pro Pro Cys Pro Gly Asn Ser 
1               5                   10              


<210>  621
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  621

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  622
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  622

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  623
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  623

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Asn Ser 
1               5                   10                  15  


<210>  624
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  624

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  625
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  625

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  626
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  626

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Asn Ser 
1               5                   10                  15  


<210>  627
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  627

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Asn Ser 
1               5                   10                  15  


<210>  628
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  628

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Asn Ser 
1               5                   10                  15  


<210>  629
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  629

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  630
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  630

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Ser Asn Ser 
1               5                   10                  15  


<210>  631
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  631

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Asn Ser 
1               5                   10                  15  


<210>  632
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  632

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Asn Ser 
1               5                   10                  15  


<210>  633
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  633

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Gly Asn Ser 
1               5                   10                  15  


<210>  634
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  634

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  635
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  635

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Gly Asn Ser 
1               5                   10                  15  


<210>  636
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  636

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Asn Ser 
1               5                   10                  15  


<210>  637
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  637

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  638
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  638

Lys Pro Phe Phe Thr Cys Gly Ser Ala Asp Thr Cys Pro Asn Ser 
1               5                   10                  15  


<210>  639
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  639

Gln Tyr Asn Cys Pro Gly Gln Tyr Thr Phe Ser Met Pro Asn Ser 
1               5                   10                  15  


<210>  640
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  640

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  641
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  641

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  642
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  642

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Ser 
1               5                   10                  15  


<210>  643
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  643

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  644
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  644

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  645
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  645

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  646
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  646

Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15  


<210>  647
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  647

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Ser 
1               5                   10                  15  


<210>  648
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  648

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Ser 
1               5                   10                  15  


<210>  649
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  649

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Ser 
1               5                   10                  15  


<210>  650
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  650

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  651
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  651

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  652
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  652

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Cys Pro 
1               5                   10                  15  


<210>  653
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  653

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  654
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  654

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  655
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  655

Gly Gly Gly Gly Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  656
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  656

Glu Pro Lys Ser Cys Gly Gly Gly Gly Gly Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  657
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  657

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Gly Gly Cys Pro 
1               5                   10                  15  


<210>  658
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  658

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Gly 
1               5                   10                  15  


<210>  659
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  659

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Ser Pro 
1               5                   10                  15  


<210>  660
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  660

Glu Pro Lys Ser Cys Asp Lys Cys His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  661
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  661

Glu Pro Lys Ser Cys Asp Lys Thr Cys Cys Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  662
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  662

Glu Pro Lys Ser Cys Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  663
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  663

Pro Pro Pro Pro Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  664
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  664

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Trp Trp Cys Pro 
1               5                   10                  15  


<210>  665
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  665

Glu Pro Lys Ser Cys Asp Trp Trp His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  666
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  666

Glu Pro Lys Cys Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  667
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  667

Glu Pro Lys Ser Asp Cys Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  668
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  668

Glu Pro Lys Ser Asp Cys Trp Trp His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  669
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  669

Glu Pro Lys Ser Cys Asp Phe Phe His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  670
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  670

Glu Pro Lys Ser Cys Asp Trp Trp Trp Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  671
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  671

Glu Pro Lys Ser Cys Trp Trp Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  672
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  672

Glu Pro Trp Trp Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  673
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  673

Ser Gln Pro Glu Ile Val Pro Ile Ser Cys Pro Pro Cys Pro Asn Ser 
1               5                   10                  15      


<210>  674
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  674

Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
1               5                   10                  15      


Pro 
    


<210>  675
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  675

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  676
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  676

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  677
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  677

Glu Pro Lys Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  678
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  678

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  679
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  679

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Gly Gly Gly Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  680
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  680

Glu Pro Lys Ser Cys Asp Gly Gly Gly Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  681
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  681

Glu Pro Lys Ser Cys Asp Pro Pro Pro Lys Thr His Thr Cys Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  682
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  682

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Pro Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  683
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  683

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Asn Ser 
        


<210>  684
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  684

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Asn Ser 
            


<210>  685
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  685

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  686
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  686

Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  687
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  687

Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala 
1               5                   10                  15      


Arg His Ser Pro 
            20  


<210>  688
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  688

Leu Ser Val Leu Ala Asn Phe Ser Gln Pro Glu Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  689
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  689

Leu Lys Ile Gln Glu Arg Val Ser Lys Pro Lys Ile Ser Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  690
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  690

Arg Glu Gln Leu Ala Glu Val Thr Leu Ser Leu Lys Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  691
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  691

Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  692
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  692

Arg Ile His Leu Asn Val Ser Glu Arg Pro Phe Pro Pro Cys Pro Pro 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  693
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  693

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Cys Pro Asn Ser 
            20  


<210>  694
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  694

Glu Glu Glu Glu Asp Glu Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu 
1               5                   10                  15      


Asp Gly Asn Ser 
            20  


<210>  695
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  695

Leu Asp Val Ser Glu Arg Pro Phe Pro Pro His Ile Gln Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  696
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  696

Asp Thr Lys Gly Lys Asn Val Leu Glu Lys Ile Phe Asp Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  697
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  697

Leu Pro Pro Glu Thr Gln Glu Ser Gln Glu Val Thr Leu Ser Cys Pro 
1               5                   10                  15      


Pro Cys Pro Asn Ser 
            20      


<210>  698
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  698

Glu Pro Ala Phe Thr Pro Gly Pro Asn Ile Glu Leu Gln Lys Asp Ser 
1               5                   10                  15      


Asp Cys Pro Asn Ser 
            20      


<210>  699
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  699

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Cys Pro Asn Ser 
            20      


<210>  700
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  700

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys Ala Arg 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  701
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  701

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25                  30          


Gly Ser Asn Ser 
        35      


<210>  702
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  702

Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg 
1               5                   10                  15      


Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys 
            20                  25                  30          


Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 
        35                  40                  45              


Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 
    50                  55                  60                  


Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 
                85                  90                  95      


Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys 
            100                 105                 110         


Gly Ser Ala Asp Thr Cys Cys Pro Asn Ser 
        115                 120         


<210>  703
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  703

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Gly Asn Ser 
1               5                   10              


<210>  704
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  704

Asn Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser Gly Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
            20                  25                  30          


Gly Gly Gly Ser Gly Asn Ser 
        35                  


<210>  705
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  705

Asn Tyr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Asn Ser 
            20  


<210>  706
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  706

Ser Pro Pro Ser Pro Asn Ser 
1               5           


<210>  707
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  707

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  708
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  708

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  709
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  709

Leu Ser Val Lys Ala Asp Phe Leu Thr Pro Ser Ile Ser Pro Pro Cys 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  710
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  710

Gly Gly Gly Ala Ser Cys Pro Pro Cys Ala Asn Ser 
1               5                   10          


<210>  711
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  711

Arg Thr Gln Arg His Asn Asn Ser Ser Leu Asn Thr Arg Thr Gln Lys 
1               5                   10                  15      


Ala Arg His Ser Gly His 
            20          


<210>  712
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  712

Arg Thr Arg Tyr Leu Gln Val Ser Gln Gln Leu Gln Gln Thr Asn Arg 
1               5                   10                  15      


Val Leu Glu Val Thr Asn Ser Ser Leu Arg Gln Gln Leu Arg Leu Lys 
            20                  25                  30          


Ile Thr Gln Leu Gly Gln Ser Ala Glu Asp Leu Gln Gly Ser Arg Arg 
        35                  40                  45              


Glu Leu Ala Gln Ser Gln Glu Ala Leu Gln Val Glu Gln Arg Ala His 
    50                  55                  60                  


Gln Ala Ala Glu Gly Gln Leu Gln Ala Cys Gln Ala Asp Arg Gln Lys 
65                  70                  75                  80  


Thr Lys Glu Thr Leu Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu 
                85                  90                  95      


Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys 
            100                 105                 110         


Gly Ser Ala Asp Thr Cys 
        115             


<210>  713
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  713

Arg Thr Gln Ser Glu Glu Gln Gln Arg Arg Ala Leu Glu Gln Lys Leu 
1               5                   10                  15      


Ser Asn Met Glu Asn Arg Leu Lys Pro Phe Phe Thr Cys Gly Ser Ala 
            20                  25                  30          


Asp Thr Cys 
        35  


<210>  714
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  714

Arg Thr Glu Gln Lys Leu Ser Asn Met Glu Asn Arg Leu Lys Pro Phe 
1               5                   10                  15      


Phe Thr Cys Gly Ser Ala Asp Thr Cys 
            20                  25  


<210>  715
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  715

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25      


<210>  716
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  716

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ala Ser 
1               5                   10                  15      


<210>  717
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  717

Ser Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  718
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence; made in lab

<400>  718

Gly Asp Gln Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro 
1               5                   10                  15      


Cys Pro 
        


<210>  719
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence

<400>  719

Pro Pro Pro Pro Pro Cys Pro Pro Cys Pro 
1               5                   10  


<210>  720
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence

<400>  720

Thr Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


<210>  721
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence

<400>  721

Ser Pro Pro Ser Pro Asn Ser 
1               5           


<210>  722
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence

<400>  722

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Ser Pro Pro Ser Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  723
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence

<400>  723

Glu Pro Thr Ser Thr Asp Lys Thr His Thr Cys Pro Pro Cys Pro Asn 
1               5                   10                  15      


Ser 
    


<210>  724
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary hinge sequence

<400>  724

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Pro Asn Ser 
            


<210>  725
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgA2UH Hinge

<400>  725
cccccacctc cccca                                                        15


<210>  726
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG1miniUH Hinge

<400>  726
gagcccaaat cttctgacaa aactcacaca agcccaccga gccca                       45


<210>  727
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgG3UH Hinge

<400>  727
gagcccaaat ctagcgacac acctccccca agcccacggt cccca                       45


<210>  728
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  IgMCH2UH Hinge

<400>  728
attgccgagc tgcctcccaa agtgagcgtc ttcgtcccac cccgcgacgg cttcttcggc       60

aacccccgca agtccaagct catctgccag gccacgggtt tcagtccccg gcagattcag      120

gtgtcctggc tgcgcgaggg gaagcaggtg gggtctggcg tcaccacgga ccaggtgcag      180

gctgaggcca aagagtctgg gcccacgacc tacaaggtga ccagcacact gaccatcaaa      240

gagagcgact ggctcagcca gagcatgttc acctgccgcg tggatcacag gggcctgacc      300

ttccagcaga atgcgtcctc catgagtgtc ccc                                   333


<210>  729
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgA2UH Hinge

<400>  729

Pro Pro Pro Pro Pro 
1               5   


<210>  730
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG1miniUH Hinge

<400>  730

Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro 
1               5                   10                  15  


<210>  731
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgG3UH Hinge

<400>  731

Glu Pro Lys Ser Ser Asp Thr Pro Pro Pro Ser Pro Arg Ser Pro 
1               5                   10                  15  


<210>  732
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  IgMCH2UH Hinge

<400>  732

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Ser Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Ser Val Pro 
            100                 105                 110     


<210>  733
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NKG2D Linker

<400>  733

Asn Ser Leu Phe Asn Gln Glu Val Gln Ile Pro Leu Thr Glu Ser Tyr 
1               5                   10                  15      


Ser Pro Asn Ser 
            20  


<210>  734
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hinge sequence

<400>  734

Ile Ala Glu Leu Pro Pro Lys Val Ser Val Phe Val Pro Pro Arg Asp 
1               5                   10                  15      


Gly Phe Phe Gly Asn Pro Arg Lys Ser Lys Leu Ile Cys Gln Ala Thr 
            20                  25                  30          


Gly Phe Ser Pro Arg Gln Ile Gln Val Ser Trp Leu Arg Glu Gly Lys 
        35                  40                  45              


Gln Val Gly Ser Gly Val Thr Thr Asp Gln Val Gln Ala Glu Ala Lys 
    50                  55                  60                  


Glu Ser Gly Pro Thr Thr Tyr Lys Val Thr Ser Thr Leu Thr Ile Lys 
65                  70                  75                  80  


Glu Ser Asp Trp Leu Gly Gln Ser Met Phe Thr Cys Arg Val Asp His 
                85                  90                  95      


Arg Gly Leu Thr Phe Gln Gln Asn Ala Ser Ser Met Ser Val Pro Cys 
            100                 105                 110         


Pro Pro Cys Pro 
        115     


<210>  735
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary leader peptide sequence

<400>  735

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  736
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Vk3 Leader Sequence

<400>  736

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  737
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary junction amino acids amino-terminal to a hinge

<400>  737

Arg Asp Gln 
1           


<210>  738
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary junction amino acids amino-terminal to a hinge

<400>  738

Ser Ala Ser Ser 
1               


<210>  739
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary junction amino acids amino-terminal to a hinge

<400>  739

Ser Ser Ser 
1           


<210>  740
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterologous leader sequence

<400>  740

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly 
            20          


<210>  741
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterologous leader sequence


<220>
<221>  VARIANT
<222>  (23)..(23)
<223>  Xaa = Any Amino Acid

<400>  741

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Xaa 
            20              


<210>  742
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterologous leader sequence


<220>
<221>  VARIANT
<222>  (23)..(24)
<223>  Xaa = Any Amino Acid

<400>  742

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Xaa Xaa 
            20                  


<210>  743
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterologous leader sequence


<220>
<221>  VARIANT
<222>  (23)..(24)
<223>  Xaa = Any Amino Acid

<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  743

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Xaa Xaa Xaa 
            20                  25  


<210>  744
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heterologous leader sequence

<400>  744

Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro 
1               5                   10                  15      


Asp Thr Thr Gly 
            20  


<210>  745
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  745

Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met Ala Gly 
1               5                   10                  15      


His Ser Pro Asn Ser 
            20      


<210>  746
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  746

Ala Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser 
1               5                   10                  15      


<210>  747
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Examplary linker sequence

<400>  747

Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser 
1               5                   10                  15  


<210>  748
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Exemplary linker sequence

<400>  748

Ala Pro Pro Cys Pro Asn Ser 
1               5           


<210>  749
<211>  717
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mature hyperIL6 fusion protein without leader sequence

<400>  749

Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu Val Ala Arg Gly Val Leu 
1               5                   10                  15      


Thr Ser Leu Pro Gly Asp Ser Val Thr Leu Thr Cys Pro Gly Val Glu 
            20                  25                  30          


Pro Glu Asp Asn Ala Thr Val His Trp Val Leu Arg Lys Pro Ala Ala 
        35                  40                  45              


Gly Ser His Pro Ser Arg Trp Ala Gly Met Gly Arg Arg Leu Leu Leu 
    50                  55                  60                  


Arg Ser Val Gln Leu His Asp Ser Gly Asn Tyr Ser Cys Tyr Arg Ala 
65                  70                  75                  80  


Gly Arg Pro Ala Gly Thr Val His Leu Leu Val Asp Val Pro Pro Glu 
                85                  90                  95      


Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser Pro Leu Ser Asn Val Val 
            100                 105                 110         


Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser Leu Thr Thr Lys Ala Val 
        115                 120                 125             


Leu Leu Val Arg Lys Phe Gln Asn Ser Pro Ala Glu Asp Phe Gln Glu 
    130                 135                 140                 


Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys Phe Ser Cys Gln Leu Ala 
145                 150                 155                 160 


Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile Val Ser Met Cys Val Ala 
                165                 170                 175     


Ser Ser Val Gly Ser Lys Phe Ser Lys Thr Gln Thr Phe Gln Gly Cys 
            180                 185                 190         


Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn Ile Thr Val Thr Ala Val 
        195                 200                 205             


Ala Arg Asn Pro Arg Trp Leu Ser Val Thr Trp Gln Asp Pro His Ser 
    210                 215                 220                 


Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe Glu Leu Arg Tyr Arg Ala 
225                 230                 235                 240 


Glu Arg Ser Lys Thr Phe Thr Thr Trp Met Val Lys Asp Leu Gln His 
                245                 250                 255     


His Cys Val Ile His Asp Ala Trp Ser Gly Leu Arg His Val Val Gln 
            260                 265                 270         


Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly Glu Trp Ser Glu Trp Ser 
        275                 280                 285             


Pro Glu Ala Met Gly Thr Pro Trp Thr Glu Ser Arg Ser Pro Pro Ala 
    290                 295                 300                 


Gly Gly Gly Ser Asp Val Ala Ala Pro His Arg Gln Pro Leu Thr Ser 
305                 310                 315                 320 


Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr Ile Leu Asp Gly Ile Ser 
                325                 330                 335     


Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser Asn Met Cys Glu Ser Ser 
            340                 345                 350         


Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn Leu Pro Lys Met Ala Glu 
        355                 360                 365             


Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn Glu Glu Thr Cys Leu Val 
    370                 375                 380                 


Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu Val Tyr Leu Glu Tyr Leu 
385                 390                 395                 400 


Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln Ala Arg Ala Val Gln Met 
                405                 410                 415     


Ser Thr Lys Val Leu Ile Gln Phe Leu Gln Lys Lys Ala Lys Asn Leu 
            420                 425                 430         


Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr Asn Ala Ser Leu Leu Thr 
        435                 440                 445             


Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln Asp Met Thr Thr His Leu 
    450                 455                 460                 


Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln Ser Ser Leu Arg Ala Leu 
465                 470                 475                 480 


Arg Gln Met Asp Gln Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 
                485                 490                 495     


Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Ser Ser Val Phe Ile 
            500                 505                 510         


Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile 
        515                 520                 525             


Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln 
    530                 535                 540                 


Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln 
545                 550                 555                 560 


Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu 
                565                 570                 575     


Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys 
            580                 585                 590         


Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys 
        595                 600                 605             


Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro 
    610                 615                 620                 


Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr 
625                 630                 635                 640 


Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys 
                645                 650                 655     


Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly 
            660                 665                 670         


Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val 
        675                 680                 685             


Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn 
    690                 695                 700                 


His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
705                 710                 715         


<210>  750
<211>  739
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Hyper IL-6 fusion protein with leader sequence

<400>  750

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Leu Ala Pro Arg Arg Cys Pro Ala Gln Glu 
            20                  25                  30          


Val Ala Arg Gly Val Leu Thr Ser Leu Pro Gly Asp Ser Val Thr Leu 
        35                  40                  45              


Thr Cys Pro Gly Val Glu Pro Glu Asp Asn Ala Thr Val His Trp Val 
    50                  55                  60                  


Leu Arg Lys Pro Ala Ala Gly Ser His Pro Ser Arg Trp Ala Gly Met 
65                  70                  75                  80  


Gly Arg Arg Leu Leu Leu Arg Ser Val Gln Leu His Asp Ser Gly Asn 
                85                  90                  95      


Tyr Ser Cys Tyr Arg Ala Gly Arg Pro Ala Gly Thr Val His Leu Leu 
            100                 105                 110         


Val Asp Val Pro Pro Glu Glu Pro Gln Leu Ser Cys Phe Arg Lys Ser 
        115                 120                 125             


Pro Leu Ser Asn Val Val Cys Glu Trp Gly Pro Arg Ser Thr Pro Ser 
    130                 135                 140                 


Leu Thr Thr Lys Ala Val Leu Leu Val Arg Lys Phe Gln Asn Ser Pro 
145                 150                 155                 160 


Ala Glu Asp Phe Gln Glu Pro Cys Gln Tyr Ser Gln Glu Ser Gln Lys 
                165                 170                 175     


Phe Ser Cys Gln Leu Ala Val Pro Glu Gly Asp Ser Ser Phe Tyr Ile 
            180                 185                 190         


Val Ser Met Cys Val Ala Ser Ser Val Gly Ser Lys Phe Ser Lys Thr 
        195                 200                 205             


Gln Thr Phe Gln Gly Cys Gly Ile Leu Gln Pro Asp Pro Pro Ala Asn 
    210                 215                 220                 


Ile Thr Val Thr Ala Val Ala Arg Asn Pro Arg Trp Leu Ser Val Thr 
225                 230                 235                 240 


Trp Gln Asp Pro His Ser Trp Asn Ser Ser Phe Tyr Arg Leu Arg Phe 
                245                 250                 255     


Glu Leu Arg Tyr Arg Ala Glu Arg Ser Lys Thr Phe Thr Thr Trp Met 
            260                 265                 270         


Val Lys Asp Leu Gln His His Cys Val Ile His Asp Ala Trp Ser Gly 
        275                 280                 285             


Leu Arg His Val Val Gln Leu Arg Ala Gln Glu Glu Phe Gly Gln Gly 
    290                 295                 300                 


Glu Trp Ser Glu Trp Ser Pro Glu Ala Met Gly Thr Pro Trp Thr Glu 
305                 310                 315                 320 


Ser Arg Ser Pro Pro Ala Gly Gly Gly Ser Asp Val Ala Ala Pro His 
                325                 330                 335     


Arg Gln Pro Leu Thr Ser Ser Glu Arg Ile Asp Lys Gln Ile Arg Tyr 
            340                 345                 350         


Ile Leu Asp Gly Ile Ser Ala Leu Arg Lys Glu Thr Cys Asn Lys Ser 
        355                 360                 365             


Asn Met Cys Glu Ser Ser Lys Glu Ala Leu Ala Glu Asn Asn Leu Asn 
    370                 375                 380                 


Leu Pro Lys Met Ala Glu Lys Asp Gly Cys Phe Gln Ser Gly Phe Asn 
385                 390                 395                 400 


Glu Glu Thr Cys Leu Val Lys Ile Ile Thr Gly Leu Leu Glu Phe Glu 
                405                 410                 415     


Val Tyr Leu Glu Tyr Leu Gln Asn Arg Phe Glu Ser Ser Glu Glu Gln 
            420                 425                 430         


Ala Arg Ala Val Gln Met Ser Thr Lys Val Leu Ile Gln Phe Leu Gln 
        435                 440                 445             


Lys Lys Ala Lys Asn Leu Asp Ala Ile Thr Thr Pro Asp Pro Thr Thr 
    450                 455                 460                 


Asn Ala Ser Leu Leu Thr Lys Leu Gln Ala Gln Asn Gln Trp Leu Gln 
465                 470                 475                 480 


Asp Met Thr Thr His Leu Ile Leu Arg Ser Phe Lys Glu Phe Leu Gln 
                485                 490                 495     


Ser Ser Leu Arg Ala Leu Arg Gln Met Asp Gln Pro Arg Gly Pro Thr 
            500                 505                 510         


Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly 
        515                 520                 525             


Gly Ser Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met 
    530                 535                 540                 


Ile Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu 
545                 550                 555                 560 


Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val 
                565                 570                 575     


His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu 
            580                 585                 590         


Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly 
        595                 600                 605             


Lys Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile 
    610                 615                 620                 


Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val 
625                 630                 635                 640 


Tyr Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr 
                645                 650                 655     


Leu Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu 
            660                 665                 670         


Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro 
        675                 680                 685             


Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val 
    690                 695                 700                 


Glu Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val 
705                 710                 715                 720 


His Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr 
                725                 730                 735     


Pro Gly Lys 
            


<210>  751
<211>  2277
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding region for a bispecific TNF binding domain (TNFR) and 
       IL6xIL6R binding domain

<400>  751
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggattgc ccgcccaggt ggcatttaca ccctacgccc cggagcccgg gagcacatgc      120

cggctcagag aatactatga ccagacagct cagatgtgct gcagcaaatg ctcgccgggc      180

caacatgcaa aagtcttctg taccaagacc tcggacaccg tgtgtgactc ctgtgaggac      240

agcacataca cccagctctg gaactgggtt cccgagtgct tgagctgtgg ctcccgctgt      300

agctctgacc aggtggaaac tcaagcctgc actcgggaac agaaccgcat ctgcacctgc      360

aggcccggct ggtactgcgc gctgagcaag caggaggggt gccggctgtg cgcgccgctg      420

cgcaagtgcc gcccgggctt cggcgtggcc agaccaggaa ctgaaacatc agacgtggtg      480

tgcaagccct gtgccccggg gacgttctcc aacacgactt catccacgga tatttgcagg      540

ccccaccaga tctgtaacgt ggtggccatc cctgggaatg caagcatgga tgcagtctgc      600

acgtccacgt cccccacccg gagtatggcc ccaggggcag tacacttacc ccagccagtg      660

tccacacgat cccaacacac gcagccaact ccagaaccca gcactgctcc aagcacctcc      720

ttcctgctcc caatgggccc cagcccccca gctgaaggga gcactggcga caccggtgag      780

cccaaatctt ctgacaaaac tcacacatgc ccaccgtgcc cagcacctga agccgcgggt      840

gcaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc      900

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac      960

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1020

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1080

aaggcgtacg cgtgcgcggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1140

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggat     1200

gagctgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tccaagcgac     1260

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     1320

gtgctggact ccgacggctc cttcttcctc tacagcaagc tcaccgtgga caagagcagg     1380

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     1440

acgcagaaga gcctctccct gtctccgggt cagaggcaca acaattcttc cctgaataca     1500

ggaactcaga tggcaggtca ttctccgaat tctgaagttc aattgttaga gtctggtggc     1560

ggtcttgttc agcctggtgg ttctttacgt ctttcttgcg ctgcttccgg attcactttc     1620

tctttttacc agatgcattg ggttcgccaa gctcctggta aaggtttgga gtgggtttct     1680

ggtatctatc cttctggtgg ctatactaag tatgctgact ccgttaaagg tcgcttcact     1740

atctctagag acaactctaa gaatactctc tacttgcaga tgaacagctt aagggctgag     1800

gacactgcag tctactattg tgcgagagat ctagggtacg gcagcacgtg gtactacttt     1860

gactactggg gccagggaac cctggtcacc gtctcaagcg gtggcggcgg ttcggggggt     1920

ggcggaagtg gaggtggagg gagtcagagc gctttgactc agcctgcctc cgtgtctggg     1980

tctcctggac agtcgatcac catctcctgc agtggaaccg acagtgacgt tggtggttat     2040

aaccatgtct cctggtacca acaacaccca ggcaaggccc ccaaactcat aatttatgat     2100

gtcgatcatc ggccctcagg gatctctaac cgtttctctg gctccaagtc tggcaacacg     2160

gcctccctga ccatctctgg gctccaggct gaggacgagg ctgattatta ctgcagctca     2220

tatagaagcg gtagcactta tcctttcgga actgggacca aggtcaccgt cctatga        2277


<210>  752
<211>  758
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific TNF binding domain (TNFR) and IL6xIL6R binding domain

<400>  752

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Thr Gly Glu Pro Lys Ser Ser Asp Lys Thr His Thr Cys Pro Pro 
            260                 265                 270         


Cys Pro Ala Pro Glu Ala Ala Gly Ala Pro Ser Val Phe Leu Phe Pro 
        275                 280                 285             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    290                 295                 300                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
305                 310                 315                 320 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                325                 330                 335     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            340                 345                 350         


Leu His Gln Asp Trp Leu Asn Gly Lys Ala Tyr Ala Cys Ala Val Ser 
        355                 360                 365             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    370                 375                 380                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
385                 390                 395                 400 


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                405                 410                 415     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            420                 425                 430         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        435                 440                 445             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    450                 455                 460                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
465                 470                 475                 480 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Gln Arg His Asn Asn Ser 
                485                 490                 495     


Ser Leu Asn Thr Gly Thr Gln Met Ala Gly His Ser Pro Asn Ser Glu 
            500                 505                 510         


Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
        515                 520                 525             


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Phe Tyr Gln 
    530                 535                 540                 


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
545                 550                 555                 560 


Gly Ile Tyr Pro Ser Gly Gly Tyr Thr Lys Tyr Ala Asp Ser Val Lys 
                565                 570                 575     


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
            580                 585                 590         


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
        595                 600                 605             


Arg Asp Leu Gly Tyr Gly Ser Thr Trp Tyr Tyr Phe Asp Tyr Trp Gly 
    610                 615                 620                 


Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
625                 630                 635                 640 


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Ala 
                645                 650                 655     


Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Ser Gly 
            660                 665                 670         


Thr Asp Ser Asp Val Gly Gly Tyr Asn His Val Ser Trp Tyr Gln Gln 
        675                 680                 685             


His Pro Gly Lys Ala Pro Lys Leu Ile Ile Tyr Asp Val Asp His Arg 
    690                 695                 700                 


Pro Ser Gly Ile Ser Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr 
705                 710                 715                 720 


Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
                725                 730                 735     


Tyr Cys Ser Ser Tyr Arg Ser Gly Ser Thr Tyr Pro Phe Gly Thr Gly 
            740                 745                 750         


Thr Lys Val Thr Val Leu 
        755             


<210>  753
<211>  2298
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Coding region for a bispecific TNF binding domain (scFv) and 
       IL6xIL6R binding domain

<400>  753
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcg       60

cgaggagagg tgcagctggt ggagtctggg ggaggcttgg tacagcccgg caggtccctg      120

agactctcct gtgcggcctc tggattcacc tttgatgatt atgccatgca ctgggtccgg      180

caagctccag ggaagggcct ggaatgggtc tcagctatca cttggaatag tggtcacata      240

gactatgcgg actctgtgga gggccgattc accatctcca gagacaacgc caagaactcc      300

ctgtatctgc aaatgaacag tctgagagct gaggatacgg ccgtatatta ctgtgcgaaa      360

gtctcgtacc ttagcaccgc gtcctccctt gactattggg gccaaggtac cctggtcacc      420

gtctcgagtg gtggcggcgg ttcggggggt ggcggaagtg gaggtggagg gagtgacatc      480

cagatgaccc agtctccatc ctccctgtct gcatctgtag gggacagagt caccatcact      540

tgtcgggcaa gtcagggcat cagaaattac ttagcctggt atcagcaaaa accagggaaa      600

gcccctaagc tcctgatcta tgctgcatcc actttgcaat caggggtccc atctcggttc      660

agtggcagtg gatctgggac agatttcact ctcaccatca gcagcctaca gcctgaagat      720

gttgcaactt attactgtca aaggtataac cgtgcaccgt atacttttgg ccaggggacc      780

aaggtggaaa tcaaaaccgg tgagcccaaa tcttctgaca aaactcacac atgcccaccg      840

tgcccagcac ctgaagccgc gggtgcaccg tcagtcttcc tcttcccccc aaaacccaag      900

gacaccctca tgatctcccg gacccctgag gtcacatgcg tggtggtgga cgtgagccac      960

gaagaccctg aggtcaagtt caactggtac gtggacggcg tggaggtgca taatgccaag     1020

acaaagccgc gggaggagca gtacaacagc acgtaccgtg tggtcagcgt cctcaccgtc     1080

ctgcaccagg actggctgaa tggcaaggcg tacgcgtgcg cggtctccaa caaagccctc     1140

ccagccccca tcgagaaaac catctccaaa gccaaagggc agccccgaga accacaggtg     1200

tacaccctgc ccccatcccg ggatgagctg accaagaacc aggtcagcct gacctgcctg     1260

gtcaaaggct tctatccaag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1320

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1380

aagctcaccg tggacaagag caggtggcag caggggaacg tcttctcatg ctccgtgatg     1440

catgaggctc tgcacaacca ctacacgcag aagagcctct ccctgtctcc gggtcagagg     1500

cacaacaatt cttccctgaa tacaggaact cagatggcag gtcattctcc gaattctgaa     1560

gttcaattgt tagagtctgg tggcggtctt gttcagcctg gtggttcttt acgtctttct     1620

tgcgctgctt ccggattcac tttctctttt taccagatgc attgggttcg ccaagctcct     1680

ggtaaaggtt tggagtgggt ttctggtatc tatccttctg gtggctatac taagtatgct     1740

gactccgtta aaggtcgctt cactatctct agagacaact ctaagaatac tctctacttg     1800

cagatgaaca gcttaagggc tgaggacact gcagtctact attgtgcgag agatctaggg     1860

tacggcagca cgtggtacta ctttgactac tggggccagg gaaccctggt caccgtctca     1920

agcggtggcg gcggttcggg gggtggcgga agtggaggtg gagggagtca gagcgctttg     1980

actcagcctg cctccgtgtc tgggtctcct ggacagtcga tcaccatctc ctgcagtgga     2040

accgacagtg acgttggtgg ttataaccat gtctcctggt accaacaaca cccaggcaag     2100

gcccccaaac tcataattta tgatgtcgat catcggccct cagggatctc taaccgtttc     2160

tctggctcca agtctggcaa cacggcctcc ctgaccatct ctgggctcca ggctgaggac     2220

gaggctgatt attactgcag ctcatataga agcggtagca cttatccttt cggaactggg     2280

accaaggtca ccgtccta                                                   2298


<210>  754
<211>  766
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Bispecific TNF binding domain (scFv) and IL6xIL6R binding domain

<400>  754

Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser 
1               5                   10                  15      


Val Ile Met Ser Arg Gly Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
            20                  25                  30          


Leu Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        35                  40                  45              


Phe Thr Phe Asp Asp Tyr Ala Met His Trp Val Arg Gln Ala Pro Gly 
    50                  55                  60                  


Lys Gly Leu Glu Trp Val Ser Ala Ile Thr Trp Asn Ser Gly His Ile 
65                  70                  75                  80  


Asp Tyr Ala Asp Ser Val Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                85                  90                  95      


Ala Lys Asn Ser Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            100                 105                 110         


Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser 
        115                 120                 125             


Ser Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile 
145                 150                 155                 160 


Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg 
                165                 170                 175     


Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu Ala 
            180                 185                 190         


Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
        195                 200                 205             


Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly 
    210                 215                 220                 


Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp 
225                 230                 235                 240 


Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr Thr Phe 
                245                 250                 255     


Gly Gln Gly Thr Lys Val Glu Ile Lys Thr Gly Glu Pro Lys Ser Ser 
            260                 265                 270         


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly 
        275                 280                 285             


Ala Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
    290                 295                 300                 


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
305                 310                 315                 320 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
                325                 330                 335     


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
            340                 345                 350         


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
        355                 360                 365             


Lys Ala Tyr Ala Cys Ala Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
    370                 375                 380                 


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
385                 390                 395                 400 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
                405                 410                 415     


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
            420                 425                 430         


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
        435                 440                 445             


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
    450                 455                 460                 


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
465                 470                 475                 480 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
                485                 490                 495     


Pro Gly Gln Arg His Asn Asn Ser Ser Leu Asn Thr Gly Thr Gln Met 
            500                 505                 510         


Ala Gly His Ser Pro Asn Ser Glu Val Gln Leu Leu Glu Ser Gly Gly 
        515                 520                 525             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    530                 535                 540                 


Gly Phe Thr Phe Ser Phe Tyr Gln Met His Trp Val Arg Gln Ala Pro 
545                 550                 555                 560 


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Tyr Pro Ser Gly Gly Tyr 
                565                 570                 575     


Thr Lys Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            580                 585                 590         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        595                 600                 605             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Leu Gly Tyr Gly Ser Thr 
    610                 615                 620                 


Trp Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
625                 630                 635                 640 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                645                 650                 655     


Gln Ser Ala Leu Thr Gln Pro Ala Ser Val Ser Gly Ser Pro Gly Gln 
            660                 665                 670         


Ser Ile Thr Ile Ser Cys Ser Gly Thr Asp Ser Asp Val Gly Gly Tyr 
        675                 680                 685             


Asn His Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
    690                 695                 700                 


Ile Ile Tyr Asp Val Asp His Arg Pro Ser Gly Ile Ser Asn Arg Phe 
705                 710                 715                 720 


Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile Ser Gly Leu 
                725                 730                 735     


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Arg Ser Gly 
            740                 745                 750         


Ser Thr Tyr Pro Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
        755                 760                 765     


