                         SEQUENCE LISTING

<110>  Richard D. DiMarchi et al.
 
<120>  Glucagon Superfamily Peptides Exhibiting Glucocorticoid Receptor 
       Activity

<130>  31135/46628A

<150>  US-61/561,094
<151>  2011-11-17

<160>  1674  

<170>  PatentIn version 3.5

<210>  1
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  2
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  2

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  3
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  3

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  4
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  4

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  5
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  5

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  6
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  6

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  7
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  7

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  8
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Glu, Gln, homoglutamic acid or homocysteic acid

<400>  8

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  9
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  9

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  10
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  10

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  11
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  11

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  12
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at position 12 and 16

<400>  12

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  13
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  13

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  14
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (22)..(24)
<223>  Lactam ring between side chains at positions 22 and 24

<400>  14

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  15
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring formed between side chains at positions 24 and 28

<400>  15

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  16
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<400>  16

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  17
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<400>  17

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Asp Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  18
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  18

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  19
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Variable amino acid

<400>  19

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Xaa 
            20                  25                  30  


<210>  20
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  20

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  21
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, Ala, Gly, N-methyl Ser or AIB

<400>  21

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  22
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<400>  22

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  23
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  23

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  24
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  24

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  25
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  25

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  26
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids Exendin-4

<400>  26

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  27
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 8 
       amino acids of oxyntomodulin

<400>  27

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  28
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  28

Lys Arg Asn Arg 
1               


<210>  29
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exendin-4


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  29

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  30
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  30

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  31
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  31

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  32
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  32

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  33
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  33

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  34
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Asp or Lys

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  34

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  35
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  35

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  36
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  36

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  37
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cys

<400>  37

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  38
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cys

<400>  38

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  39
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  39

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  40
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  40

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  41
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 12
       and 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  41

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  42
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  42

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Thr 
            20                  25                  


<210>  43
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Glu or Asp

<400>  43

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Thr 
            20                  25                  


<210>  44
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Glu or Thr

<400>  44

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  45
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys or Glu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Gln, Glu, Lys, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Glu or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  45

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  46
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<400>  46

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  47
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  47

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  48
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  48

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  49
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue

<400>  49

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Thr 
            20                  25                  


<210>  50
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  50

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  51
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Glu, homoglutamic acid, or homocysteic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly or an acidic amino acid

<400>  51

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  52
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  52

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  53
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or an acidic amino acid

<400>  53

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  54
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg or Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg or Ala

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp or Glu

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Ala

<400>  54

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Xaa Xaa Ala Lys Xaa Phe Xaa Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  55
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His or
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Tyr or Trp

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Lys, Citrulline, Orn or Arg

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Arg, Gln, Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Arg, Ala, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocystein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Arg, Citrulline, Orn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  55

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Xaa Ser Xaa Tyr Leu Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  56
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocycsteine or acetyl phenyalanine

<400>  56

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  57
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl- His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side changes at position 12 and 16

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Cys, Orn, homocycsteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl Phe

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  57

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  58
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln, Glu, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  58

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Xaa Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  59
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB, or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at position 20 and 24

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl pheylalanine

<400>  59

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Lys Xaa Phe Xaa Glu Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  60
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, D-Ala, Val, Gly, N-methyl Ser, AIB or N-methyl 
       Ala

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Gln, Glu, Orn or  Nle

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, cysteic acid, homoglutamic acid and homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln, Lys, Arg, Orn, or Citrulline

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Gln, Glu, Asp, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  Val or Ile

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at position 24 and 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr, Gly, Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  60

Xaa Xaa Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Xaa Glu Trp Leu Xaa Lys Xaa 
            20                  25                  


<210>  61
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, Aib, N-methyl, Ala or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  61

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Xaa Ala Lys Asp Phe Val Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  62
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<223>  positions 30 to 40 are present only if position 29 is Gly; see 
       specification as filed for detailed description of substitutions 
       and preferred embodiments

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  His, D-His, (Des-amino)His, hydroxyl-His, acetyl-His, homo-His, 
       DMIA, N-methyl His, alpha-methyl His, or imidazole acetic acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Ser, D-Ser, Ala, Val, Gly, N-methyl Ser, AIB0, N-methyl Ala, or 
       D-Ala

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  Ala or Arg

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Ala, Gln or Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr-CONH2, Cys-PEG, or Gly

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG or not present

<400>  62

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Xaa Ala Lys Glu Phe Ile Xaa Trp Leu Met Asn Xaa Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  63
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Asp, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln, Lys, Cys, Orn, homocysteine or acetyl phealanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met, Leu or Nle

<400>  63

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  64
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Asp, Glu, homoglutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Gln or Lys

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Gln or Glu

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asn, Lys or Asp

<400>  64

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Xaa Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Pro Pro Pro Ser 
        35              


<210>  65
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide fragment representing the carboxy terminal 10 
       amino acids of Exdendin-4


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Cys-PEG

<400>  65

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  66
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  66

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  67
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  67

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  68
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Glucagon Analogue


<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam ring between side chains at positions 20 and 24

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Asp or Asn

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  68

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Glu Trp Leu Met Xaa Xaa 
            20                  25                  


<210>  69
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam ring between side chains at positions 24 and 28

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Thr or Gly

<400>  69

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Glu Trp Leu Met Lys Xaa 
            20                  25                  


<210>  70
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  70

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  71
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  71

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  72
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  72

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  73
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  73

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  74
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  74

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  75
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  75

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  76
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  76

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  77
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  77

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  78
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  78

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  79
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  79

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  80
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  80

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  81
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  81

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  82
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  82

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  83
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  83

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  84
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  84

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  85
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  85

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  86
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  86

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  87
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  87

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  88
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  88

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  89
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  89

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  90
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  90

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  91
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  91

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  92
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  92

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  93
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  c-term amidation

<400>  93

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  94
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  94

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  95
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  95

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  96
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  96

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  97
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  97

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  98
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  98

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  99
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  99

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  100
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  100

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  101
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  101

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  102
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C-terminal amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  102

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  103
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  C-terminal amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  103

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  104
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  104

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  105
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  105

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  106
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  106

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  107
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  107

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  108
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  108

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  109
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  109

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  110

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  111
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  111

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  112

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  113
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  113

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  114
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  114

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  115
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  115

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  116
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  116

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  117
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  117

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  118
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  118

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  119
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  119

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  120
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  120

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  121
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  121

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  122
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  122

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  123
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  123

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  124
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  124

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  125
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  125

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  126
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  126

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  127

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  128

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  129

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  130

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  131

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  132
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  132

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  133
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  133

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  134
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  134

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  135
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  135

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  136
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  136

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  137
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  137

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  138
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  138

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  139
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  139

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  140
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  140

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  141
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  141

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  142
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  142

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  143
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  143

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  144
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  144

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  145
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  145

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  146
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  146

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  147
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  147

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  148
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  148

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  149
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  149

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  150
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  150

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  151

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  152
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  152

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  153
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  153

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  154
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  154

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  155
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  155

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  156
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  156

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  157
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  157

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  158
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  158

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  159
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  159

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  160
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  160

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  161
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  161

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  162
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  162

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  163
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  163

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  164
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  164

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  165
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  165

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  166
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  166

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  167
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  167

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  168
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  168

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  169
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  169

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  170
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  170

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  171
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  171

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  172
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  172

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  173
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  173

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  174
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  174

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  175
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  175

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  176
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  176

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  177

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  178

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  179
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  179

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  180
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  180

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  181
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  181

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  182
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  182

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  183
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  183

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  184
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  184

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  185

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  186
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  186

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  187
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  187

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  188
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  188

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  189
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  189

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  190
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  190

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  191
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  191

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  192
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  192

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  193
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  193

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  194
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  194

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  195
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  195

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  196
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  196

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  197
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  197

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  198
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  198

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  199
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  199

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  200
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  200

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  201
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  201

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  202
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  202

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  203
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  203

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  204
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  204

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  205
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  205

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  206
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  206

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  207
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  207

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  208
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  208

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  209
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  209

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  210
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  210

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  211
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  211

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  212
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  212

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  213
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  213

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  214
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  214

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  215
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  215

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  216
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  216

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  217
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  217

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  218
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  218

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  219
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  219

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  220
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  220

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  221
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  221

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  222
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  222

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  223
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  223

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  224
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  224

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  225
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  225

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  226
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  226

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  227
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  227

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  228
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  228

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  229
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  229

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  230
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  230

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  231
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  231

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  232
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  232

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  233
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  233

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  234
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  234

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  235
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  XAa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  235

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  236
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  236

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  237
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  237

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  238
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  238

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  239
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  239

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  240

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  241

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  242

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  243

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  244
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  244

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  245

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  246
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  246

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  247
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  247

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  248
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  248

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  249
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  249

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  250
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  250

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  251

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  252
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  252

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  253
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  253

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  254
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  254

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  255
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  255

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  256

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  257
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  257

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  258
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  258

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  259
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  259

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  260
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chrains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  260

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  261
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  261

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  262
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  262

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  263
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  263

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  264
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  264

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  265
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  265

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  266
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  266

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  267
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  267

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  268
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  268

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  269
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring betwee side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  269

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  270
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring betwee side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  270

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  271
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  271

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  272
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal midation

<400>  272

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  273
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  273

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  274
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  274

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  275
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  275

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  276
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  276

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  277
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  277

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  278
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  278

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  279
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  279

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  280
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  280

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  281
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  281

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  282
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  282

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  283
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  283

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  284
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  284

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  285
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  285

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  286
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  286

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  287
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chain at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  287

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  288
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  288

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  289
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  289

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  290
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  290

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  291
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  291

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  292
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  292

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  293
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  293

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  294
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  294

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  295
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  295

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  296
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  296

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  297
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  297

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  298
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  298

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  299
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  299

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  300
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  300

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  301
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  301

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  302
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  302

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  303
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  303

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  304
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  304

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  305
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (des-amino)His

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  305

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  306
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  306

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  307
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  307

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Gly Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  308
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  308

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  309
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  309

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  310
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  310

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  311
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chain at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  311

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  312
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  312

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  313
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  313

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  314
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  314

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  315
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between seide chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  315

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  316
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  316

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  317
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  317

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  318
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  318

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  319
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  319

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  320
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  320

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  321
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  321

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  322
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  322

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  323
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  323

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  324
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at position 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  324

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  325
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  325

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  326
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  326

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  327
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  327

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  328
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  328

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  329
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  329

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  330
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  330

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  331
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  331

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  332
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  332

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  333
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  333

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  334
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  334

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  335
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chainst at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  335

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  336
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  336

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  337
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  337

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  338
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam right between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  338

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  339
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  339

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  340
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  340

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  341
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  341

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly 
            20                  25                  


<210>  342
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  342

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  343
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  343

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  344
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  344

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  345
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  345

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  346
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  346

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  347
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  347

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  348
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  348

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  349
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  349

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  350
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  350

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  351
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  351

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  352
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  352

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  353
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  353

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  354
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  354

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  355
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  355

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  356
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  356

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  357
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  357

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  358
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  358

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  359
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  359

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  360
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  360

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  361
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  361

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  362
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  362

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  363
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  363

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  364
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  364

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  365
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  365

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  366
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  366

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  367
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  367

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  368
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  368

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  369
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  369

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  370
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  370

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  371
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  371

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  372
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  372

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  373
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Cys-PEG

<400>  373

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly 
            20                  25                  


<210>  374
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  374

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  375
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  375

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  376
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  376

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  377
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  377

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  378
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  378

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  379
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  379

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  380
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  380

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  381
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation; lactam ring between side chains at positions 16
       and 20

<400>  381

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  382
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  382

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  383
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  383

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  384
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  384

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  385
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  385

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  386
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  386

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  387
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  387

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  388
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  388

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  389
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  389

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  390
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  390

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  391
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  391

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  392
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<400>  392

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  393
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  393

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  394
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  394

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  395
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  395

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  396
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  396

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  397
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  397

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  398
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  398

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  399
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  399

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  400
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  400

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  401
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  401

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  402
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  402

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  403
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  403

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  404
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  404

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  405
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  405

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  406
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  406

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  407
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  407

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  408
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  c-term amidation

<400>  408

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  409
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  409

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  410
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  410

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  411
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  411

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  412
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  412

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  413
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  413

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  414
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  414

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  415
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  415

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  416
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  416

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  417
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  417

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  418
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  418

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  419
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  419

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  420
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  420

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  421
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  421

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  422
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  422

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  423
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  423

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  424
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  424

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  425
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  425

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  426
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  426

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  427
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  427

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  428
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  428

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  429
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  429

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  430
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  430

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  431
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  431

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  432
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  432

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  433
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  433

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  434
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  434

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  435
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  435

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  436
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  436

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  437
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 16 and 20

<400>  437

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  438
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  438

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  439
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  439

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  440
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  440

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  441
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  441

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  442
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  442

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  443
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  443

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  444
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  444

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  445
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  445

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  446
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  446

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  447
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<223>  Lactam ring between side chains at positions 12 and 16

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  447

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  448
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  448

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  449
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  449

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  450
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  450

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  451
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  451

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  452
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  C-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  452

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  453
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  453

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  454
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  454

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  455
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<400>  455

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  456
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  456

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  457
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  (Des-amino)His

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  457

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  458
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  458

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  459
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  459

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  460
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  460

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  461
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  461

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  462
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  462

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  463
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  463

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  464
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  464

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  465
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  465

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  466
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at postions 12 and 16

<400>  466

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  467
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  467

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  468
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  468

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  469
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<400>  469

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  470
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  470

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  471
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  471

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  472
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  472

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  473
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  473

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  474
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  474

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  475
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  475

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  476
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  476

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  477
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  477

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  478
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  478

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  479
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  479

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  480
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  480

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  481
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  481

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  482
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  482

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Ala Ala Glu Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  483
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<400>  483

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  484
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam ring between side chains at positions 12 and 16

<400>  484

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  485
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-Ala

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<400>  485

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  486
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  486

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  487
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  487

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  488
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  488

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  489
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  489

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  490
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  490

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  491
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  491

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  492
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  492

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  493
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  493

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  494
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  494

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  495
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  495

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  496
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  496

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  497
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  497

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  498
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  498

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr Ala 
            20                  25                  30  


<210>  499
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  499

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  500
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  500

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  501
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  501

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  502
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  502

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  503
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  503

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  504
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  504

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  505
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  505

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  506
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha-Dimethly Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  506

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  507
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  507

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  508
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  508

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  509
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  509

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  510
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  510

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  511
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  511

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  512
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  512

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Cys 
            20                  25                  


<210>  513
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  513

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  514
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  514

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  515
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  515

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  516
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  Cys-PEG

<400>  516

Gly Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10          


<210>  517
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  517

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  518
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  518

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  519
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethly Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  519

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  520
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Cys-PEG

<400>  520

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  521
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  521

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  522
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  522

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  523
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  523

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  524
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  524

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  525
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  525

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  526
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  526

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  527
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  527

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly 
            20                  25                  30  


<210>  528
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains at positions 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  528

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  529
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  529

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  530
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Alpha, Alpha Dimethyl Imidiazole Acetic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  530

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  531
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<400>  531

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  532
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (41)..(41)
<223>  Cys-PEG

<400>  532

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys Cys 
        35                  40      


<210>  533
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  c-term amidation

<400>  533

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  534
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C8 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C8 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  534

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  535
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C14 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C14 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  535

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  536
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C16 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  536

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  537
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 AIB2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  537

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  538
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  538

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  539
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  539

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  540
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<400>  540

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  541
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys24-40K

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  541

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  542
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acid

<400>  542

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  543
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<400>  543

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  544
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<400>  544

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  545
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  545

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  546
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-W-C16 Cys 24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  546

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  547
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  547

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  548
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C18 Cys24-40K

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C18 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  548

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  549
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon E16 K20 K10-C16 amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to Glu residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  549

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  550
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by one amino acid

<400>  550

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn 
            20                  25              


<210>  551
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 truncated by two amino acids

<400>  551

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met 
            20                  25          


<210>  552
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-28, E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  552

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn 
            20                  25              


<210>  553
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  aa 1-27 E16 K20 C-terminal amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<400>  553

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Lys Met 
            20                  25          


<210>  554
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Norleucine

<400>  554

His Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  555
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridging side chains at positions 16 and 20

<400>  555

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  556
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2 with AIB at 16

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  556

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  557
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  557

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  558
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  558

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  559
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutric Acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutric Acid

<400>  559

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  560
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<400>  560

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  561
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Covalently bound to Trp residue comprising a C16 fatty acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Aminoisobutyric acid

<400>  561

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  562
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric acid

<400>  562

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  563
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  563

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  564
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  564

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  565
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  565

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  566
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  566

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  567
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via 6-aminohexanoic acid 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  567

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  568
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Leu-Leu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  568

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  569
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Pro-Pro spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  569

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  570
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  570

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  571
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  571

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  572
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  572

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  573
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  573

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  574
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  574

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  575
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  575

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  576
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  576

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  577
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  577

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  578
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  578

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  579
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  AA-C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<400>  579

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  580
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera 2, AIB2, Lys10, Cys24-PEG

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  580

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  581
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C14 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<400>  581

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  582
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C14)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<400>  582

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  583
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C16 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<400>  583

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  584
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C16)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  584

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  585
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K10-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  585

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  586
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide Chimera 2-AIB2-K30-acylated

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C18 fatty acyl group

<400>  586

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  587
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<400>  587

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  588
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  588

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  589
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<400>  589

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  590
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  590

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  591
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  591

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  592
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  592

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  593
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  593

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  594
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  594

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  595
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  595

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  596
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  596

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  597
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  597

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  598
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  598

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  599
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Norleucine

<400>  599

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  600
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  600

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  601
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  601

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  602
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  602

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  603
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  603

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  604
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutyric Acid

<400>  604

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  605
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  605

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  606
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic Acid

<400>  606

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  607
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  607

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  608
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  608

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  609
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  609

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  610
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  610

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  611
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  611

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  612
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  612

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  613
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<400>  613

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  614
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<400>  614

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  615
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C18 fatty acyl group

<400>  615

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  616
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  616

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  617
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  617

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  618
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  618

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  619
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via di peptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  619

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  620
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covelently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  620

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  621
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  621

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  622
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<400>  622

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  623
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  beta-Ala-beta-Ala - C16 Glucagon Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<400>  623

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  624
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2C24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  624

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  625
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera-2 Aib2E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of the amino acids at positions 
       16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  625

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  626
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2E16K20lactamC24amideMal40KPEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  626

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  627

<400>  627
000

<210>  628
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  628

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  629
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24Mal40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with a maleimide-activated PEG

<400>  629

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  630
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Dmia1E16K20lactamC24thioether40KPEG

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at position 16 and
       20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  630

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  631
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Chimera2 Aib2E3C24-Thioether40K PEG

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  631

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  632
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  632

Xaa Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  633
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16C24K10(rErE-C16) C24PEG40K amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  633

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  634
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C14)C24PEG40K TE amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  634

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  635
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(AA-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  635

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  636
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(rErE-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  636

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  637
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  637

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  638
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  638
caaggtccag ggaggttgtg                                                   20


<210>  639
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  639
ccaaaggtaa gctgtccata agga                                              24


<210>  640
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  640
ctctcccaag agtcacatgt cc                                                22


<210>  641
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic primer

<400>  641
caataactcg gtcccctaca ac                                                22


<210>  642
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  642

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  643
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  643

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  644
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  644

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  645
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  645

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  646
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  646

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  647
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  647

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  648
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  648

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  649
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  649

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  650
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  650

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  651
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  651

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  652
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  652

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  653
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<400>  653

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  654
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<400>  654

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  655
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu-gamma-Glu 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  655

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  656
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  656

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  657
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  657

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  658
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutyric Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  658

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  659
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  659

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  660
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  660

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  661
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  661

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  662
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C14 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<400>  662

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  663
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C14)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<400>  663

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  664
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2E16K20K30-C16 Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<400>  664

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  665
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide dS2K10(C16)E16K20-Gluc Amide

<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<400>  665

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  666
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group

<400>  666

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  667
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group

<400>  667

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  668
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C18 fatty acyl group

<400>  668

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  669
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<400>  669

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  670
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16C24K10(rErE-C16) C24PEG40K amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  670

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  671
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Aib2Aib16K10(rErE-C16) amide

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  671

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  672
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  672

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  673
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  673

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  674
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  674

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  675
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  675

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  676
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  676

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  677
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  677

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  678
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  678

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  679
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  679

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  680
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<400>  680

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  681
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<400>  681

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  682
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Dmia

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids at positions 16 
       and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<400>  682

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Lys 
            20                  25                  


<210>  683
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  683

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  684
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  c-term amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  684

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  685
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  685

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Gly Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  686
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  686

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  687
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  687

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  688
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C18 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  688

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  689
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  689

His Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  690
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<400>  690

His Xaa Gln Gly Thr Phe Ile Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  691
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  691

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  692
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  692

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Glu Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  693
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  693

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  694
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  694

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  695
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  695

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Asp Thr 
            20                  25                  


<210>  696
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  696

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  697
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  697

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  698
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  698

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  699
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  699

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  700
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  700

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  701
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  701

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  702
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  702

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  703
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  703

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  704
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<400>  704

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  705
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  705

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Glu 
            20                  25                  30      


<210>  706
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  706

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  707
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  707

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  708
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  708

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  709
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  709

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu 
            20                  25                  30  


<210>  710
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  710

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  711
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  711

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  712
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  des-amino-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  712

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  713
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ac-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  713

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  714
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  714

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  715
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  715

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  716
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  716

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  717
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  717

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  718
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  718

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  719
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  719

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  720
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  720

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  721
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  721

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  722
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  722

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  723
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  723

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  724
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  724

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  725
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  725

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  726
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  726

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  727
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  727

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  728
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-Ser

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  728

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  729
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  729

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  730
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via gamma-Glu spacer

<220>
<221>  MISC_FEATURE
<222>  (15)..(20)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  730

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  731
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  731

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  732
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  732

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  733
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  733

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  734
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  734

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  735
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  735

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  736
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  736

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  737
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  737

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  738
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  738

His Ala Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  739
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  739

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  740
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  740

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr 
            20                  25                  


<210>  741
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  741

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  742
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<400>  742

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  743
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  743

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Glu 
            20                  25                  30      


<210>  744
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  744

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Gly Gly 
            20                  25                  30      


<210>  745
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  745

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  746
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  746

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Ala Ala Gln Asp Phe Val Gln Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  747
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  747

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Glu 
            20                  25                  30  


<210>  748
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<400>  748

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr Cys 
            20                  25                  30  


<210>  749
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  749

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  750
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  des-amino-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  750

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  751
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Ac-His

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  751

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Leu Asp Thr 
            20                  25                  


<210>  752
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  752

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  753
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  753

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  754
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  754

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  755
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  755

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  756
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  756

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Met Asn Thr 
            20                  25                  


<210>  757
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  757

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  758
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  PEGYLATION

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  758

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  759
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Salt bridge

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  759

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  760
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with C16 fatty acyl group via acidic amino acid spacer

<220>
<221>  MISC_FEATURE
<222>  (15)..(20)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (16)..(21)
<223>  Salt bridge

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  760

His Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Lys Arg Ala Lys Glu Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  801

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  802
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  802

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  803
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Xaa is Arg, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  803

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Xaa Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  804
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  804

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  805
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  805

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  806
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  806

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Xaa Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  807
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Lys, Arg, His, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Lys, Arg, His, Asp, Glu, cysteic acid or homocysteic 
       acid

<400>  807

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  808
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Asp or Glu

<400>  808

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  809
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Asp or Glu

<400>  809

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asn Xaa 
            20                  25                  


<210>  810
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  810

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  811
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  811

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  812
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Lys, Arg or His

<400>  812

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Xaa 
            20                  25                  


<210>  813
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  813

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  814
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  814

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Cys 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  815
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  815

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  816
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  816

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  817
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  817

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  818
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  818

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Lys Phe Val Gln Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  819
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<400>  819

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Lys Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  820
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing carboxy terminal 10 amino acids of 
       Exendin-4

<400>  820

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  821
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  821

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  822
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the amino 4 amino acids of 
       oxyntomodulin carboxy terminus of SEQ ID NO: 21

<400>  822

Lys Arg Asn Arg 
1               


<210>  823
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  823

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  824
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  824

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  825
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  825

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  826
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  826

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  827
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  827

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  828
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  828

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  829
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through Cys thiol group

<400>  829

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  830
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through Cys thiol group

<400>  830

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  831
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  831

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  832
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analog


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Xaa is Asp, Glu, Lys, Arg or His

<400>  832

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Xaa 
            20                  25                  30  


<210>  833
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn, Lys, Arg, His, Asp or Glu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Lys, Arg, His, Asp or Glu

<400>  833

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  834
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr or an acidic amino acid

<400>  834

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  835
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  835

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  836
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  836

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  837
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  837

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr Lys Arg Asn 
            20                  25                  30          


Arg 
    


<210>  838
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue

<400>  838

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Glu Thr 
            20                  25                  


<210>  839
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is any amino acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Met comprises Z

<400>  839

Xaa Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met 
            20                  25          


<210>  840
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<400>  840

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  841
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Glutamine to alanine mutation

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Pegylation

<400>  841

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Ala Trp Leu Met Asn Cys 
            20                  25                  


<210>  842
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylation

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle or Leu

<400>  842

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  25                  


<210>  843
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is alpha, alpha-dimethyl imidiazole acetic acid (DMIA)

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Glutamine to alanine mutation

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa is Nle or Leu

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Pegylation

<400>  843

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Ala Trp Leu Xaa Asn Cys 
            20                  25                  


<210>  844
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with  Ala 20, Ala 24, Nle 27, and Asp 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  844

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  845
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle27 , Asp 28, and Glu 29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  845

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  846
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Asp 28, and Glu 30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  846

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asp Thr Glu 
            20                  25                  30  


<210>  847
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Glu 28, and Glu 29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  847

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Glu Glu 
            20                  25                  


<210>  848
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Glu 28, and Glu 30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  848

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Glu Thr Glu 
            20                  25                  30  


<210>  849
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  SEQ ID NO: 1 with Ala 20, Ala 24, Nle 27, Glu 29, and Glu 30

<400>  849

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Xaa Asn Glu Glu 
            20                  25                  30  


<210>  850
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, and Asp 28

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  850

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Thr 
            20                  25                  


<210>  851
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Asp 28, and Glu
       29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  851

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  852
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Asp 28, and Glu
       30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  852

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  853
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO :1 with Ala 20, Glu 21, Ala 24, Nle 27, Glu 28, and Glu
       29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  853

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Glu Glu 
            20                  25                  


<210>  854
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Glu 28, and Glu
       30

<400>  854

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  855
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Ala 20, Glu 21, Ala 24, Nle 27, Glu 29, and Glu
       30

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  855

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asn Glu Glu 
            20                  25                  30  


<210>  856
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  SEQ ID NO: 1 with Thr 16, Ala 20, Glu 21, Ala 24, Nle 27, Asp 28,
       and Glu29

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  856

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  857
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  857

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  858
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  858

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  859
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  859

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  860
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  860

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  861
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  861

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  862
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  862

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  863
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  863

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  864
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  864

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  865
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  865

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  866
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  866

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  867
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  867

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  868
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  868

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  869
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  869

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  870
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  870

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  871
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  871

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  872
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  AMIDATION

<400>  872

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  873
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryric acid

<400>  873

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  874
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aminoisobutryic acid

<400>  874

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  875
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  875

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Glu 
            20                  25                  


<210>  876
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  876

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Glu 
            20                  25                  


<210>  877
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid

<400>  877

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  878
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  878

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  879
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  879

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  880
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  880

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  881
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  881

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  882
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-Ser

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  882

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  883
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  883

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  884
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Aminoisobutryic Acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C18 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  884

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  885
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Ser or alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Gln or alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Asp or alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Gln or alpha, alpha-disubstituted amino acid

<400>  885

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Xaa Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  886
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  886

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  887
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Xaa is Aib

<400>  887

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Xaa Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  888
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<400>  888

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  889
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Xaa is Aib

<400>  889

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Xaa Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  890
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  890

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  891
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<400>  891

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  892
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  892

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  893
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  893

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  894
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Xaa is Aib

<400>  894

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Xaa Trp Leu Met Asn Thr 
            20                  25                  


<210>  895
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  895

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  896
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  896

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  897
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  897

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  898
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  898

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  899
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  899

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  900
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via beta-Ala-beta-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  900

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  901
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via 6-aminohexanoic acid 
       spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  901

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  902
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Leu-Leu spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  902

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  903
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Pro-Pro spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  903

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  904
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  904

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  905
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  905

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  906
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  906

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  907
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  907

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  908
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  908

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  909
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  909

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  910
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys-PEG

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  910

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  911
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  911

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  912
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  912

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  913
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C14 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  913

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  914
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covalently bound to C16 fatty acyl group via dipeptide spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  914

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  915
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Covelently bound to C16 fatty acyl group via Ala-Ala spacer

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  915

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  916
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  916

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  917
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  917

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  918
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  918

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr Lys 
            20                  25                  30  


<210>  919
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  D-serine, D-alanine, valine, amino n-butyric acid, glycine, 
       N-methyl serine, aminoisobutyric acid

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  919

His Xaa Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  920

<400>  920
000

<210>  921

<400>  921
000

<210>  922

<400>  922
000

<210>  923

<400>  923
000

<210>  924

<400>  924
000

<210>  925

<400>  925
000

<210>  926

<400>  926
000

<210>  927

<400>  927
000

<210>  928

<400>  928
000

<210>  929

<400>  929
000

<210>  930

<400>  930
000

<210>  931

<400>  931
000

<210>  932

<400>  932
000

<210>  933

<400>  933
000

<210>  934

<400>  934
000

<210>  935

<400>  935
000

<210>  936

<400>  936
000

<210>  937

<400>  937
000

<210>  938

<400>  938
000

<210>  939

<400>  939
000

<210>  940

<400>  940
000

<210>  941

<400>  941
000

<210>  942

<400>  942
000

<210>  943

<400>  943
000

<210>  944

<400>  944
000

<210>  945

<400>  945
000

<210>  946

<400>  946
000

<210>  947

<400>  947
000

<210>  948

<400>  948
000

<210>  949

<400>  949
000

<210>  950

<400>  950
000

<210>  951

<400>  951
000

<210>  952

<400>  952
000

<210>  953

<400>  953
000

<210>  954

<400>  954
000

<210>  955

<400>  955
000

<210>  956

<400>  956
000

<210>  957

<400>  957
000

<210>  958

<400>  958
000

<210>  959

<400>  959
000

<210>  960

<400>  960
000

<210>  961

<400>  961
000

<210>  962

<400>  962
000

<210>  963

<400>  963
000

<210>  964

<400>  964
000

<210>  965

<400>  965
000

<210>  966

<400>  966
000

<210>  967

<400>  967
000

<210>  968

<400>  968
000

<210>  969

<400>  969
000

<210>  970

<400>  970
000

<210>  971

<400>  971
000

<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000

<400>  1000
000

<210>  1001
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Wild type glucagon

<400>  1001

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1002
<211>  31
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(31)
<223>  GLP-1(7-37)

<400>  1002

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  1003
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(30)
<223>  GLP-1(7-36) amidated

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  1003

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1004
<211>  42
<212>  PRT
<213>  Homo sapiens


<220>
<221>  mat_peptide
<222>  (1)..(42)
<223>  gastric inhibitory polypeptide

<400>  1004

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1005
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 61

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20.

<400>  1005

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1006
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 62

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20.

<400>  1006

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1007
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 63

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam bridge between residues 12 and 16.

<400>  1007

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1008
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 66

<400>  1008

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1009
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 68

<400>  1009

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1010
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 69

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1010

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Ile His Gln Glu Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1011
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 84

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1011

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Cys Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1012
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 85

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (20kDa) covalently attached to Cysteine

<400>  1012

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Cys Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1013
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 92

<400>  1013

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1014
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 93

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (17)..(21)
<223>  Lactam bridge between residues 17 and 21

<400>  1014

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Lys His Gln Lys Glu Phe Ile Ala Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1015
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 95

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1015

His Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1016
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 96

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1016

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1017
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 97

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1017

His Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1018
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 98

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1018

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1019
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 99

<400>  1019

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1020
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 100

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  1020

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1021
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 101

<400>  1021

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1022
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 102

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  1022

Tyr Xaa Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1023
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 104

<400>  1023

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1024
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 105

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) attached to Cysteine

<400>  1024

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Cys Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1025
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 106

<400>  1025

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1026
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 107

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1026

His Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1027
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 108

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1027

His Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Ala Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Ile Ala Trp Leu Met Asn Thr 
            20                  25                  


<210>  1028
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 109

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1028

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1029
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 110

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1029

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1030
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 111

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1030

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1031
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 113

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is 3-phenyllactic acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge between residues 11 and 15

<400>  1031

Xaa Ile Ser Asp Tyr Ser Ile Ala Met Asp Glu Ile His Gln Lys Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln 
            20                  


<210>  1032
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 114

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is 3-phenyllactic acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge between residues 11 and 15

<400>  1032

Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Ile His Gln Lys Asp 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gln 
            20                  


<210>  1033
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 115

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1033

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1034
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 116

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1034

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1035
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 118

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1035

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Glu Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1036
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 120

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1036

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1037
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 124

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1037

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1038
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 125

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1038

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Val Asn Trp Leu Leu Ala Gln 
            20                  25                  


<210>  1039
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 127

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1039

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1040
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 128

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1040

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1041
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 129

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1041

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Ile His Gln Lys Asp Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1042
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 139

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1042

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1043
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 140

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1043

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1044
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 141

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residuess 16 and 20

<400>  1044

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Met Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1045
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 142

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1045

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1046
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 143

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1046

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1047
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 144

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1047

Tyr Ala Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Met Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1048
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 145

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1048

Tyr Ala Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1049
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 146

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1049

Tyr Ala Gln Gly Thr Phe Ile Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1050
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 147

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1050

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1051
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 148

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1051

Tyr Ser Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1052
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 149

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1052

Tyr Ala Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1053
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 150

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1053

Tyr Ser Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1054
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 151

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1054

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1055
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 152

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1055

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1056
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 154

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is hippuric acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1056

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1057
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 155

<220>
<221>  MISC_FEATURE
<222>  (12)..(16)
<223>  Lactam bridge between residues 12 and 16

<400>  1057

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1058
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 156

<220>
<221>  MISC_FEATURE
<222>  (20)..(24)
<223>  Lactam bridge between residues 20 and 24

<400>  1058

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Glu Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1059
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 157

<220>
<221>  MISC_FEATURE
<222>  (24)..(28)
<223>  Lactam bridge between residues 24 and 28

<400>  1059

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Glu Trp Leu Leu Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1060
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 158

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1060

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1061
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 162

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1061

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Tyr Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Val Lys Glu Phe Val Asn Trp Leu Ile Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1062
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 163

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1062

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1063
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 164

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1063

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1064
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 165

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1064

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1065
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 166

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is d-alanine

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1065

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1066
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 167

<220>
<221>  MISC_FEATURE
<222>  (17)..(20)
<223>  Lactam bridge between residues 17 and 20

<400>  1066

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1067
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 168

<220>
<221>  MISC_FEATURE
<222>  (18)..(21)
<223>  Lactam bridge between residues 18 and 21

<400>  1067

Tyr Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Lys Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1068
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 169

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1068

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1069
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 170

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1069

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1070
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 172

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1070

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1071
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 174

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1071

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1072
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 175

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1072

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1073
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 176

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1073

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1074
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 177

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1074

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1075
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 178

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1075

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1076
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 179

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1076

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1077
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 182

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1077

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1078
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 186

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1078

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Cys Trp Leu Met Asn Gly 
            20                  25                  


<210>  1079
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 191

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  1079

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1080
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 192

<400>  1080

Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1081
<211>  38
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 194

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Aib

<400>  1081

Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Glu 
1               5                   10                  15      


Ala Val Arg Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser Ser 
            20                  25                  30          


Gly Ala Pro Pro Pro Ser 
        35              


<210>  1082
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 197

<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  Lactam bridge between residues 13 and 17

<400>  1082

Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln Ala Ala 
1               5                   10                  15      


Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25      


<210>  1083
<211>  28
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 198

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge between residues 15 and 19

<400>  1083

Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25              


<210>  1084
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 199

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1084

Tyr Xaa Gln Gly Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1085
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 200

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1085

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1086
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 201

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  1086

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1087
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 202

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1087

Tyr Xaa Gln Gly Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1088
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 203

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1088

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1089
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 204

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1089

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1090
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 205

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1090

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1091
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 206

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1091

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  1092
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 207

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1092

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  1093
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 208

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1093

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Cys 
        35                  40              


<210>  1094
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Analog 209

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (9)..(12)
<223>  Lactam bridge between residues 9 and 12

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<400>  1094

Tyr Xaa Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1095
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  CEX

<400>  1095

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  1096
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is any amino acid

<400>  1096

Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10      


<210>  1097
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1097

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  1098
<211>  4
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  1098

Lys Arg Asn Arg 
1               


<210>  1099
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1099

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1100
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1100

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1101
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1101

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1102
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1102

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1103
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1103

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1104
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1104

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1105
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1105

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1106
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1106

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1107
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1107

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1108
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1108

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1109
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1109

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1110
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1110

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1111
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1111

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1112
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is Aib

<400>  1112

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1113
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1113

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1114
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1114

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1115
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1115

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1116
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1116

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Lys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1117
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1117

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1118
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1118

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1119
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1119

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1120
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1120

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1121
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Orn

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1121

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1122
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is 2,4-diaminobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1122

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1123
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalentaly attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1123

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1124
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1124

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1125
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1125

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1126
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1126

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1127
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1127

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1128
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1128

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1129
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1129

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1130
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1130

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1131
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1131

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1132
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1132

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1133
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1133

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1134
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1134

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1135
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1135

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1136
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1136

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1137
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1137

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1138
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1138

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1139
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1139

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1140
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1140

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1141
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1141

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1142
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1142

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1143
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1143

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1144
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1144

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1145
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  18 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1145

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1146
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1146

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1147
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  3-SH-propionic acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1147

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1148
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  8 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1148

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1149
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1149

Tyr Xaa Gln Gly Thr Phe Ser Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1150
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  Xaa is 2-aminobutyric acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1150

Tyr Xaa Gln Gly Thr Phe Xaa Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1151
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  8 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1151

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1152
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  8 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1152

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1153
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1153

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1154
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is d-Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to d-Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1154

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1155
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is d-Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1155

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1156
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is d-Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1156

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1157
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa is d-Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1157

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1158
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1158

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1159
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1159

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1160
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1160

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1161
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1161

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1162
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1162

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1163
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1163

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1164
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1164

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1165
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1165

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1166
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently attached to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1166

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1167
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1167

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1168
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1168

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1169
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (12)..(16)
<223>  Lactam bridge between residues 12 and 16

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1169

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1170
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1170

Gly Pro Ser Ser Gly Ala Pro Pro Pro Lys 
1               5                   10  


<210>  1171
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Gly or a small, aliphatic or non-polar or slightly polar 
       amino acid

<400>  1171

Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Lys 
1               5                   10      


<210>  1172
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic  polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Gly or a small, aliphatic or non-polar or slightly polar 
       amino acid

<400>  1172

Xaa Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Lys 
1               5                   10          


<210>  1173
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synethic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1173

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1174
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  PEG (40kDa) covalently attached to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1174

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1175
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1175

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1176
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1176

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1177
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1177

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1178
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  C-terminal amidation

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<400>  1178

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Ser 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1179
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  PEG (40kDa) covalently attached to Cysteine

<400>  1179

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1180
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1180

Tyr Ala Pro Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Xaa Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1181
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalentaly linked to hydrophilic group

<400>  1181

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1182
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa can be any naturally occurring amino acid

<400>  1182

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Leu Ala Xaa 
            20                  25                  


<210>  1183
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1183

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1184
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1184

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1185
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Sythetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1185

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1186
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1186

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1187
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1187

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Xaa Trp Leu Met Asn Gly 
            20                  25                  


<210>  1188
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substitute amino acid covalently linked to hydrophilic group

<400>  1188

Tyr Xaa Gln Gly Thr Phe Val Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1189
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1189

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Xaa Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1190
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1190

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Arg Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1191
<211>  43
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge between residues 16 and 20

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1191

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Lys Gly Lys 
            20                  25                  30          


Lys Asn Trp Leu Lys His Asn Ile Thr Gln Xaa 
        35                  40              


<210>  1192
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1192

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1193
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1193

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1194
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substitute amino acid covalently linked to an acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1194

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1195
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to an acyl or alkyl 
       group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1195

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1196
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1196

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1197
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1197

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1198
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1198

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1199
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1199

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1200
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1200

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1201
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1201

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1202
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1202

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1203
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1203

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1204
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1204

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1205
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1205

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1206
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1206

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1207
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1207

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1208
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1208

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1209
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1209

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1210
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1210

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1211
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1211

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1212
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1212

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1213
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1213

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1214
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1214

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1215
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1215

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1216
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1216

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1217
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1217

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Cys Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1218
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1218

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa Cys 
        35                  40      


<210>  1219
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1219

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Xaa Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1220
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1220

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa Xaa 
        35                  40      


<210>  1221
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<400>  1221

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Xaa 
        35                  40      


<210>  1222
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1222

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1223
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to acyl or alkyl group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1223

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Xaa Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1224
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1224

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1225
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Substituted amino acid covalently linked to hydrophilic group

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1225

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Gln Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1226
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Substituted amino acid covalently linked to hydrophilic group

<400>  1226

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1227
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1227

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1228
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, D-Ala, Val, Gly, N-Methyl Ser, N-Methyl Ala, or Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys, Glu, Ser, Orn, Dab, Aib or any alpha, 
       alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is any alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Ile, Leu, or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Ala or Gly

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Ala, or Gly

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1228

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  1229
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1229

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Lys 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Leu Ala Gly 
            20                  25                  


<210>  1230
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is D-Ser, DAla, Val, Gly, N-Methyl Ser, N-Methyl Ala, or Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Lys, Glu, Ser, Orn, Dab, Aib or any alpha, 
       alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is any alpha, alpha-disubstituted amino acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Ile, Leu, or Nle

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Xaa is Ala or Gly

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  Xaa is Thr, Ala, or Gly

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1230

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Xaa Asp Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  25                  


<210>  1231
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Homodimer

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently bound to Lysine

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<220>
<221>  DISULFID
<222>  (41)..(41)
<223>  Disulfide bond formed with Cys residue of a second peptide having
       the same structure.

<400>  1231

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1232
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1232

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1233
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1233

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1234
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently bound to Lysine

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1234

Tyr Xaa Gln Gly Thr Phe Ile Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1235
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently bound to Lysine via a 
       dipeptide spacer

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1235

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1236
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  16 Carbon fatty acyl group covalently bound to Lysine via a 
       dipeptide spacer

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1236

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1237
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  16 Carbon fatty acyl group covalently bound to Lysine via 
       dipeptide spacer

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1237

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Lys Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1238
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  Homodimer

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covelently bound to Lysine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Cys residue covalently attached to 20 kDa PEG which is in turn 
       covalently attached to a Cys residue of a second peptide having 
       the same structure

<400>  1238

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1239
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MISC_FEATURE
<223>  homodimer

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  14 Carbon fatty acyl group covalently bound to Lysine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  PEG (5kDa) covalently bound to Cysteine

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  C-terminal amidation

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Cys residue covalently attached to 5 kDa PEG which is in turn 
       covalently attached to a Cys residue of a second peptide having 
       the same structure

<400>  1239

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Lys 
1               5                   10                  15      


Gln Ala Ala Xaa Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys Cys 
        35                  40      


<210>  1240
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1240

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1241
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is a Glutamine analog

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1241

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  1242
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1242

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1243
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetamidomethyl-cysteine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1243

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1244
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1244

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1245
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is carbamoyldiaminopropanoic acid

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1245

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1246
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1246

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1247
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methionine sulfoxide

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1247

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1248
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetylornithine

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  Xaa is Nle

<400>  1248

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Thr 
1               5                   10                  15      


Arg Arg Ala Ala Glu Phe Val Ala Trp Leu Xaa Asp Glu 
            20                  25                  


<210>  1249
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1249

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  1250
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1250

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  1251
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Methylglutamine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1251

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Met Asp Glu 
            20                  25                  


<210>  1252
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  1252

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  1253
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1253

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Glu 
            20                  25                  


<210>  1254
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  C-terminal amidation

<400>  1254

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ala Asp Phe Val Ala Trp Leu Leu Asp Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1255
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1255

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Ser Asp Phe Val Ser Trp Leu Leu Asp Glu 
            20                  25                  


<210>  1256
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide


<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is Acetyldiaminobutanoic acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<400>  1256

His Ser Xaa Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Arg Arg Ala Thr Asp Phe Val Thr Trp Leu Leu Asp Glu 
            20                  25                  


<210>  1257

<400>  1257
000

<210>  1258

<400>  1258
000

<210>  1259
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge links Glu16 and Lys20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Epsilon amine of Lys is attached to Ala-Ac-Cys(PEG), wherein the 
       Ac-Cys(PEG) is a Cys residue comprising an alpha amino group 
       capped with an acetyl group (CH3CO) and comprising a 40 kDa PEG 
       covalently attached to its side chain

<400>  1259

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1260
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge links Glu16 and Lys20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Epsilon amine of Lys is attached to Arg-Ac-Cys(PEG), wherein the 
       Ac-Cys(PEG) is a Cys residue comprising an alpha amino group 
       capped with an acetyl group (CH3CO) and comprising a 40 kDa PEG 
       covalently attached to its side chain

<400>  1260

Tyr Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1261
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge links Glu16 and Lys20

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Cys-PEG covalently linked via thioether linkage

<400>  1261

Tyr Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Leu Ala Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1262
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<400>  1262

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1263
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-345

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1263

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1264
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-346

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1264

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1265
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-347

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1265

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1266
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-348

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1266

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1267
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-349

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1267

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1268
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-350

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1268

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1269
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-351

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C14 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1269

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1270
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-352

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether made by reaction of 
       peptide with haloacetyl-activated PEG

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1270

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1271

<400>  1271
000

<210>  1272
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-361

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1272

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1273
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-362

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1273

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Ile Tyr Leu Asp Xaa 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Val Asn Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1274
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-363

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1274

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1275
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<223>  MT-364

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Aib

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Acylated with a C16 fatty acyl group

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  AMIDATION

<400>  1275

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1276

<400>  1276
000

<210>  1277

<400>  1277
000

<210>  1278

<400>  1278
000

<210>  1279

<400>  1279
000

<210>  1280

<400>  1280
000

<210>  1281

<400>  1281
000

<210>  1282

<400>  1282
000

<210>  1283

<400>  1283
000

<210>  1284

<400>  1284
000

<210>  1285

<400>  1285
000

<210>  1286

<400>  1286
000

<210>  1287

<400>  1287
000

<210>  1288

<400>  1288
000

<210>  1289

<400>  1289
000

<210>  1290

<400>  1290
000

<210>  1291

<400>  1291
000

<210>  1292

<400>  1292
000

<210>  1293

<400>  1293
000

<210>  1294

<400>  1294
000

<210>  1295

<400>  1295
000

<210>  1296

<400>  1296
000

<210>  1297

<400>  1297
000

<210>  1298

<400>  1298
000

<210>  1299

<400>  1299
000

<210>  1300

<400>  1300
000

<210>  1301
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1301

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1302
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  1302

Ser Gln Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1303
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  1303

Gln Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg 
1               5                   10                  15      


Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25          


<210>  1304
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  1304

Gly Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala 
1               5                   10                  15      


Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25      


<210>  1305
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<400>  1305

Thr Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln 
1               5                   10                  15      


Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25  


<210>  1306
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa at position 22 is Met, Leu or Nle

<400>  1306

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1307
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1307

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1308
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is  Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1308

Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1309
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1309

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1310
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1310

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1311
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypetide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1311

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  1312
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1312

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  1313
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1313

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1314
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1314

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  


<210>  1315
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Pegylated

<400>  1315

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Cys 
            20                  


<210>  1316
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1316

Phe Thr Ser Xaa Tyr Ser Arg Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Xaa Asn Thr 
            20                  


<210>  1317
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1317

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Asn Thr 
            20                  


<210>  1318
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1318

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Glu Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1319
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  1319

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  1320
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  1320

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  1321
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy 4 amino acids of 
       oxyntomodulin carboxy terminus

<400>  1321

Lys Arg Asn Arg 
1               


<210>  1322
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<400>  1322

Phe Thr Ser Arg Tyr Ser Xaa Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Asn Thr 
            20                  


<210>  1323
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1323

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1324
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1324

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  1325
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1325

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1326
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylation

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1326

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  1327
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1327

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  1328
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1328

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  1329
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1329

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1330
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1330

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg Asn Asn Ile Ala 
            20                  25                  30          


<210>  1331
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1331

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Cys 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Lys Arg Asn Arg 
            20                  25              


<210>  1332
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1332

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1333
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1333

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1334
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cysteine

<400>  1334

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1335
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Carboxymethyl group bound through thiol group of Cysteine

<400>  1335

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1336
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1336

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Glu Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1337
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1337

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1338
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1338

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Glu Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1339
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa id Thr, Asp, Glu, cysteic acid or homocysteic acid

<400>  1339

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1340
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1340

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1341
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, glu or Asp

<400>  1341

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1342
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu, cysteic acid, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1342

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1343
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  20kDa PEG group attached to Xaa at position 11

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1343

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Cys Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1344
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  20kDa PEG group attached to Xaa at position 16

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1344

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Cys 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1345
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1345

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1346
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Lys, Cys, Orn, homocycstein or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Pegylated

<400>  1346

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser 
        35  


<210>  1347
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  1347

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  1348
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1348

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1349
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met , Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  1349

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  1350
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1350

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1351
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1351

Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp Phe Val Gln Trp 
1               5                   10                  15      


Leu Met Asn Thr 
            20  


<210>  1352
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is Homocysteic acid

<400>  1352

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1353
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<400>  1353

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  1354
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  1354

His Ser Gln Gly Thr Xaa 
1               5       


<210>  1355
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  1355

Ser Gln Gly Thr Xaa 
1               5   


<210>  1356
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  1356

Gln Gly Thr Xaa 
1               


<210>  1357
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is phenyl lactic acid

<400>  1357

Gly Thr Xaa 
1           


<210>  1358
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is phenyl lactic acid

<400>  1358

Thr Xaa 
1       


<210>  1359
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  1359

Xaa Xaa Xaa Gly Thr Xaa 
1               5       


<210>  1360
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  1360

Xaa Xaa Gly Thr Xaa 
1               5   


<210>  1361
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu and Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  1361

Xaa Gly Thr Xaa 
1               


<210>  1362
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  1362

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1363
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  1363

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1364
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  Optional C-terminal alpha carboxylate replaced with amide

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  1364

Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1365
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine in position 5 and phenyl lactic acid in position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate optionally replaced with amide

<400>  1365

His Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1366
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is amino isobutyric acid

<400>  1366

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1367
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1367

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1368
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1368

Xaa Xaa Xaa Thr Gly Phe 
1               5       


<210>  1369
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1369

Xaa Xaa Thr Gly Phe 
1               5   


<210>  1370
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1370

Xaa Thr Gly Phe 
1               


<210>  1371
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate optionally replaced with an amide

<400>  1371

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1372

<400>  1372
000

<210>  1373

<400>  1373
000

<210>  1374

<400>  1374
000

<210>  1375

<400>  1375
000

<210>  1376

<400>  1376
000

<210>  1377

<400>  1377
000

<210>  1378

<400>  1378
000

<210>  1379

<400>  1379
000

<210>  1380

<400>  1380
000

<210>  1381

<400>  1381
000

<210>  1382

<400>  1382
000

<210>  1383

<400>  1383
000

<210>  1384

<400>  1384
000

<210>  1385

<400>  1385
000

<210>  1386

<400>  1386
000

<210>  1387

<400>  1387
000

<210>  1388

<400>  1388
000

<210>  1389

<400>  1389
000

<210>  1390

<400>  1390
000

<210>  1391

<400>  1391
000

<210>  1392

<400>  1392
000

<210>  1393

<400>  1393
000

<210>  1394

<400>  1394
000

<210>  1395

<400>  1395
000

<210>  1396

<400>  1396
000

<210>  1397

<400>  1397
000

<210>  1398

<400>  1398
000

<210>  1399

<400>  1399
000

<210>  1400

<400>  1400
000

<210>  1401
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1401

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1402
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1402

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1403
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1403

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  1404
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  1404

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1405
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1405

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1406
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1406

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1407
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<400>  1407

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Asn Thr 
            20                  


<210>  1408
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<400>  1408

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Lys Thr 
            20                  


<210>  1409
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa at position 7 is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, homoglutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1409

Phe Thr Ser Asp Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Xaa Xaa 
            20                  


<210>  1410
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln or Glu

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<400>  1410

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Met Xaa Thr 
            20                  


<210>  1411
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Gln, homoglutamic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Gln or Lys

<400>  1411

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1412
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Arg

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Lys, Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1412

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Asp Glu Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  1413
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (16)..(16)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1413

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1414
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Lys or Gln

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenylalanine

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1414

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Asn Thr 
            20                  


<210>  1415
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid, homoglutamic 
       acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys Gln, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Arg, Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or an acidic amino acid

<400>  1415

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1416
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1416

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1417
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1417

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1418
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1418

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Xaa Thr 
            20                  


<210>  1419
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ser or Glu

<220>
<221>  MISC_FEATURE
<222>  (19)..(23)
<223>  Lactam bridge connecting residues 19 and 23

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr or Glu

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1419

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Xaa Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Lys Xaa 
            20                  


<210>  1420
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys Gln, homoglutamic acid or homocysteine

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Arg, Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys, Asp, Glu, cysteic acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Asp, Glu, cysteic acid and homocysteic acid

<400>  1420

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1421
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  1421

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  1422
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1422

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1423
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1423

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1424
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1424

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Asn Thr 
            20                  


<210>  1425
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid and homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (19)..(24)
<223>  Lactam bridge connecting residues 19 and 24

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<400>  1425

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Xaa Lys Thr 
            20                  


<210>  1426
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  1426

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  1427
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy 4 amino acids of 
       oxyntomodulin carboxy terminus

<400>  1427

Lys Arg Asn Arg 
1               


<210>  1428
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1428

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1429
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1429

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1430
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<400>  1430

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1431
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1431

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1432
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1432

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1433
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<400>  1433

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1434
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1434

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1435
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<400>  1435

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1436
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<400>  1436

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1437
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1437

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ala Arg Tyr Leu Asp Ala 
1               5                   10                  15      


Arg Arg Ala Arg Glu Phe Ile Lys Trp Leu Val Arg Gly Arg Gly 
            20                  25                  30      


<210>  1438
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1438

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1439
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1439

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Asn Thr 
            20                  


<210>  1440
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1440

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Cys Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1441
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<400>  1441

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1442
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  2-butyrolactone bound through thiol group of Cysteine

<400>  1442

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1443
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon Analogue

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  Carboxymethyl group bound through thiol group of Cysteine

<400>  1443

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Cys Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1444
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  1444

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Arg Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Arg Asn Thr Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1445
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  Pegylated

<400>  1445

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro 
            20                  25                  30          


Pro Pro Ser 
        35  


<210>  1446
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Asp, Glu, cysteic acid and homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa is Cys, Orn, homocysteine or acetyl phenyalanine

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<400>  1446

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Xaa Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Xaa 
        35  


<210>  1447
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, homoglutamic acid, cysteic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Glu or Asp

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<400>  1447

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1448
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is glutamic acid, homoglutamic acid,  cysteic acid or 
       homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp or Glu

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Asp or Glu

<400>  1448

Phe Thr Ser Xaa Tyr Ser Lys Tyr Leu Xaa Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Xaa Xaa Thr 
            20                  


<210>  1449
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<400>  1449

Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp Phe 
1               5                   10                  15      


Val Gln Trp Leu Met Asp Thr 
            20              


<210>  1450
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4 plus one additional amino acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is selected form the group consisting of Cys, Orn, Lys, 
       homocysteine and acetyl phenyalanine

<400>  1450

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Xaa 
1               5                   10      


<210>  1451
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<223>  Glucagon analogue

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is aspartic acid, glutamic acid, cysteic acid, homoglutamic 
       acid or homocysteic acid

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Asp, Glu, cysteic acid, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is Ala, Ser, Glu, Lys Gln, homoglutamic acid or homocysteic 
       acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Arg, Gln, Glu or Lys

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa is Ala, Gln, Lys or Glu

<220>
<221>  MISC_FEATURE
<222>  (22)..(22)
<223>  Xaa is Met, Leu or Nle

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is Asn, Lys or an acidic amino acid

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa is Thr, Gly or an acidic amino acid

<400>  1451

Phe Thr Ser Xaa Tyr Ser Xaa Tyr Leu Xaa Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Xaa Trp Leu Xaa Xaa Xaa 
            20                  


<210>  1452
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  1452

His Ser Gln Gly Thr Xaa 
1               5       


<210>  1453
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  1453

Ser Gln Gly Thr Xaa 
1               5   


<210>  1454
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  1454

Gln Gly Thr Xaa 
1               


<210>  1455
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is phenyl lactic acid

<400>  1455

Gly Thr Xaa 
1           


<210>  1456
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is phenyl lactic acid

<400>  1456

Thr Xaa 
1       


<210>  1457
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<400>  1457

Xaa Xaa Xaa Gly Thr Xaa 
1               5       


<210>  1458
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, Val, Gly, N-methyl serine, N-methyl alanine, and 
       aminoisobutyric acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<400>  1458

Xaa Xaa Gly Thr Xaa 
1               5   


<210>  1459
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa is phenyl lactic acid

<400>  1459

Xaa Gly Thr Xaa 
1               


<210>  1460
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1460

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1461
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1461

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1462
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Lactam bridge connecting residues 4 and 7

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1462

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1463
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1463

Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1464
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 are 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1464

Ala Glu Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1465
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1465

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1466
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 are 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1466

Ser Gln Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1467
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Covalently linked to a cholesterol acid moiety

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 to 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1467

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1468
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (25)..(25)
<223>  Covalently linked to a cholesterol acid moiety

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1468

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Lys 
            20                  25  


<210>  1469
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connectiong residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Covalently linked to a cholesterol acid moiety

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1469

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Lys 
        35  


<210>  1470
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is amino isobutyric acid

<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine in position 4 and phenyl lactic acid in position 5 are 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connectiong residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1470

Xaa Glu Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1471
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1471

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1472
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1472

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1473
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1473

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1474
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-termincal alpha carboxylate replaced with amide

<400>  1474

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1475
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1475

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1476
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1476

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1477
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1477

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Asp Thr 
            20                  


<210>  1478
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (19)..(23)
<223>  Lactam bridge connecting residues 19 and 23

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1478

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Glu Trp Leu Met Lys Thr 
            20                  


<210>  1479
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1479

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Gln Ala Ala Lys Asp 
1               5                   10                  15      


Phe Ile Ala Trp Leu Met Asp Thr 
            20                  


<210>  1480
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1480

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Met Asp Thr 
            20                  


<210>  1481
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1481

Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1482
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1482

Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Gln 
1               5                   10                  15      


Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25              


<210>  1483
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge connection residues 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1483

His Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  1484
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge connecting bridges 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1484

His Ala Glu Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asp Thr 
            20                  25                  


<210>  1485
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (13)..(17)
<223>  Lactam bridge connecting residues 13 and 17

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1485

Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala 
1               5                   10                  15      


Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25      


<210>  1486
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine in position 5 and phenyl lactic acid in position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (15)..(19)
<223>  Lactam bridge connecting residues 15 and 19

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1486

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg 
1               5                   10                  15      


Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25              


<210>  1487
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threonine at position 5 and phenyl lactic acid at position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam bridge connecting residues 16 and 20

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1487

His Ala Glu Gly Thr Xaa Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Gln Trp Leu Met Asp Thr 
            20                  25                  


<210>  1488
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1488

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asp Thr 
            20                  


<210>  1489
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (7)..(11)
<223>  Lactam bridge connecting residues 7 and 11

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1489

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Cys 
        35  


<210>  1490
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1490

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asp Thr 
            20                  


<210>  1491
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1491

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Cys 
        35  


<210>  1492
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Covalently attached to a C16 fatty acid

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connection residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1492

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1493
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1493

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1494
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Linked to C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1494

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1495
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1495

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Met Asp Thr 
            20                  


<210>  1496
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1496

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Lys 
            20                  


<210>  1497
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is amino isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1497

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1498
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is alpha isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1498

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Xaa Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asn Thr 
            20                  


<210>  1499
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1499

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1500
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1500

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asn Thr 
            20                  


<210>  1501
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Lactam bridge connecting residues 4 and 7

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is alpha isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal carboxylate replaced with amide

<400>  1501

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1502
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Lactam bridge connecting residues 4 and 7

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Xaa is alpha isobutyric acid

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal carboxylate replaced with amide

<400>  1502

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Xaa Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1503
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1503

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Glu 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1504
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1504

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Gln Ala Ala Lys Glu 
1               5                   10                  15      


Phe Ile Ala Trp Leu Met Asn Thr 
            20                  


<210>  1505
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (34)..(34)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1505

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser 
        


<210>  1506
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Linked to a C16 fatty acid via Glu residue

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal carboxylate replaced with amide

<400>  1506

Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1507
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa1 is selected from a group consisting of His, D-histidine, 
       alpha, alpha-dimethyl imidiazole acetic acid (DMIA), N-methyl 
       histidine, alpha-methyl histidine, imidazole acetic acid, 
       desaminohistidine, hydroxyl-histidine, acetyl-histidine and

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, valine, glycine, N-methyl serine, and aminoisobutyric 
       acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1507

Xaa Xaa Xaa Thr Gly Phe 
1               5       


<210>  1508
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Ser, D-serine, 
       D-alanine, valine, glycine, N-methyl serine, and aminoisobutyric 
       acid (AIB)

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1508

Xaa Xaa Thr Gly Phe 
1               5   


<210>  1509
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is selected from a group consisting of Glu or Gln

<400>  1509

Xaa Thr Gly Phe 
1               


<210>  1510
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1510

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr 
            20                  


<210>  1511
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1511

Ser Gln Gly Thr Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1512
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (4)..(5)
<223>  Threonine at position 4 and phenyl lactic acid at position 5 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1512

Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser Arg 
1               5                   10                  15      


Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25              


<210>  1513
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (5)..(6)
<223>  Threorine at position 5 and phenyl lactic acid at position 6 
       linked via ester bond

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa is phenyl lactic acid

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1513

His Ser Gln Gly Thr Xaa Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1514
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1514

Phe Thr Ser Glu Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Cys Trp Leu Met Asn Thr 
            20                  


<210>  1515
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Pegylated via spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1515

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Met Asp Thr 
            20                  


<210>  1516
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  Pegylated via rigid spacer

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1516

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Lys Trp Leu Met Asp Thr 
            20                  


<210>  1517
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate replaced with amide

<400>  1517

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Thr Gly Pro Gly Pro Gly Pro Gly Pro 
            20                  25                  30          


Gly Pro Cys 
        35  


<210>  1518
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Polypeptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<220>
<221>  MISC_FEATURE
<222>  (11)..(15)
<223>  Lactam bridge connecting residues 11 and 15

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  Pegylated

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  C-terminal alpha carboxylate reaplaced with amide

<400>  1518

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu Arg Arg Ala Lys Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asp Gly Gly Pro Ser Ser Gly Ala Pro Pro 
            20                  25                  30          


Pro Ser Cys 
        35  


<210>  1519

<400>  1519
000

<210>  1520

<400>  1520
000

<210>  1521

<400>  1521
000

<210>  1522

<400>  1522
000

<210>  1523

<400>  1523
000

<210>  1524

<400>  1524
000

<210>  1525

<400>  1525
000

<210>  1526

<400>  1526
000

<210>  1527

<400>  1527
000

<210>  1528

<400>  1528
000

<210>  1529

<400>  1529
000

<210>  1530

<400>  1530
000

<210>  1531

<400>  1531
000

<210>  1532

<400>  1532
000

<210>  1533

<400>  1533
000

<210>  1534

<400>  1534
000

<210>  1535

<400>  1535
000

<210>  1536

<400>  1536
000

<210>  1537

<400>  1537
000

<210>  1538

<400>  1538
000

<210>  1539

<400>  1539
000

<210>  1540

<400>  1540
000

<210>  1541

<400>  1541
000

<210>  1542

<400>  1542
000

<210>  1543

<400>  1543
000

<210>  1544

<400>  1544
000

<210>  1545

<400>  1545
000

<210>  1546

<400>  1546
000

<210>  1547

<400>  1547
000

<210>  1548

<400>  1548
000

<210>  1549

<400>  1549
000

<210>  1550

<400>  1550
000

<210>  1551

<400>  1551
000

<210>  1552

<400>  1552
000

<210>  1553

<400>  1553
000

<210>  1554

<400>  1554
000

<210>  1555

<400>  1555
000

<210>  1556

<400>  1556
000

<210>  1557

<400>  1557
000

<210>  1558

<400>  1558
000

<210>  1559

<400>  1559
000

<210>  1560

<400>  1560
000

<210>  1561

<400>  1561
000

<210>  1562

<400>  1562
000

<210>  1563

<400>  1563
000

<210>  1564

<400>  1564
000

<210>  1565

<400>  1565
000

<210>  1566

<400>  1566
000

<210>  1567

<400>  1567
000

<210>  1568

<400>  1568
000

<210>  1569

<400>  1569
000

<210>  1570

<400>  1570
000

<210>  1571

<400>  1571
000

<210>  1572

<400>  1572
000

<210>  1573

<400>  1573
000

<210>  1574

<400>  1574
000

<210>  1575

<400>  1575
000

<210>  1576

<400>  1576
000

<210>  1577

<400>  1577
000

<210>  1578

<400>  1578
000

<210>  1579

<400>  1579
000

<210>  1580

<400>  1580
000

<210>  1581

<400>  1581
000

<210>  1582

<400>  1582
000

<210>  1583

<400>  1583
000

<210>  1584

<400>  1584
000

<210>  1585

<400>  1585
000

<210>  1586

<400>  1586
000

<210>  1587

<400>  1587
000

<210>  1588

<400>  1588
000

<210>  1589

<400>  1589
000

<210>  1590

<400>  1590
000

<210>  1591

<400>  1591
000

<210>  1592

<400>  1592
000

<210>  1593

<400>  1593
000

<210>  1594

<400>  1594
000

<210>  1595

<400>  1595
000

<210>  1596

<400>  1596
000

<210>  1597

<400>  1597
000

<210>  1598

<400>  1598
000

<210>  1599

<400>  1599
000

<210>  1600

<400>  1600
000

<210>  1601
<211>  29
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1601

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Pro Val Gln Trp Leu Met Asn Thr 
            20                  25                  


<210>  1602
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analog


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  N-terminal amino group replaced with hydroxy group

<400>  1602

Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser Arg Arg Ala Gln Asp 
1               5                   10                  15      


Phe Val Gln Trp Leu Met Asn Thr 
            20                  


<210>  1603
<211>  31
<212>  PRT
<213>  Homo sapiens

<400>  1603

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 
            20                  25                  30      


<210>  1604
<211>  30
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  AMIDATION

<400>  1604

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1605
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  1605

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly 
            20                  25              


<210>  1606
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1606

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Ser 
1               5                   10                  15      


Arg Arg Ala Gln Asp Phe Val Gln Trp Leu Met Asp Thr Lys Arg Asn 
            20                  25                  30          


Arg Asn Asn Ile Ala 
        35          


<210>  1607
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  1607

Tyr Ala Glu Gly Thr Phe Ile Ser Asp Tyr Ser Ile Ala Met Asp Lys 
1               5                   10                  15      


Ile His Gln Gln Asp Phe Val Asn Trp Leu Leu Ala Gln Lys Gly Lys 
            20                  25                  30          


Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
        35                  40          


<210>  1608
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  1608

His Ala Asp Gly Ser Phe Ser Asp Glu Met Asn Thr Ile Leu Asp Asn 
1               5                   10                  15      


Leu Ala Ala Arg Asp Phe Ile Asn Trp Leu Ile Gln Thr Lys Ile Thr 
            20                  25                  30          


Asp 
    


<210>  1609
<211>  49
<212>  PRT
<213>  Homo sapiens

<400>  1609

Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro Asp Pro Leu 
1               5                   10                  15      


Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys Asp Glu Leu 
            20                  25                  30          


Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe Tyr Gly Pro 
        35                  40                  45              


Val 
    


<210>  1610
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4

<400>  1610

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  1611
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4


<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  AMIDATION

<400>  1611

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser 
1               5                   10  


<210>  1612
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 10 amino acids
       of Exendin-4


<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  Pegylation

<400>  1612

Gly Pro Ser Ser Gly Ala Pro Pro Pro Ser Cys 
1               5                   10      


<210>  1613
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 13 amino acids
       of GIP peptide

<400>  1613

Lys Gly Lys Lys Asn Asp Trp Lys His Asn Ile Thr Gln 
1               5                   10              


<210>  1614
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  peptide fragment representing the carboxy terminal 8 amino acids 
       of oxyntomodulin

<400>  1614

Lys Arg Asn Arg Asn Asn Ile Ala 
1               5               


<210>  1615
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Glucagon analogue


<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  C-terminal amide

<400>  1615

His Thr Arg Gly Thr Phe 
1               5       


<210>  1616
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-histidine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  d-threonine

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  d-arginine

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  d-threonine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  d-phenylalanine

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  C-terminal amidation

<400>  1616

Xaa Xaa Xaa Gly Xaa Xaa 
1               5       


<210>  1617
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  glucagon analogue


<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  pegylation

<400>  1617

His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Arg 
            20                  25                  30  


<210>  1618
<211>  39
<212>  PRT
<213>  Heloderma suspectum

<400>  1618

His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu Glu 
1               5                   10                  15      


Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser 
        35                  


<210>  1619
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  1619

Tyr Ala Asp Ala Ile Phe Thr Asn Ser Tyr Arg Lys Val Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Arg Lys Leu Leu Gln Asp Ile Met Ser Arg 
            20                  25                  


<210>  1620
<211>  28
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  AMIDATION

<400>  1620

His Ser Asp Ala Val Phe Thr Asp Asn Tyr Thr Arg Leu Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Asn Ser Ile Leu Asn 
            20                  25              


<210>  1621
<211>  27
<212>  PRT
<213>  Homo sapiens

<400>  1621

His Ser Asp Gly Ile Phe Thr Asp Ser Tyr Ser Arg Tyr Arg Lys Gln 
1               5                   10                  15      


Met Ala Val Lys Lys Tyr Leu Ala Ala Val Leu 
            20                  25          


<210>  1622
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  1622

His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met 
            20                  25          


<210>  1623
<211>  27
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  AMIDATION

<400>  1623

His Ser Asp Gly Thr Phe Thr Ser Glu Leu Ser Arg Leu Arg Glu Gly 
1               5                   10                  15      


Ala Arg Leu Gln Arg Leu Leu Gln Gly Leu Val 
            20                  25          


<210>  1624
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Cys residue linked to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  1624

His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Asn 
            20                  25                  30  


<210>  1625
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Covalently bound to 40K PEG via thioether

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  AMIDATION

<400>  1625

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  1626
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Sarcosine (N-methyl glycine)

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  1626

Lys Gly His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1627
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-hexyl-glycine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  1627

Lys Gly His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1628
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-lysine

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-methyl phenylalanine

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  1628

Lys Phe His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1629
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40 kDa PEG via maleimide

<400>  1629

His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  1630
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is DMIA

<220>
<221>  MISC_FEATURE
<222>  (16)..(20)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (29)..(29)
<223>  C-terminal amidation

<400>  1630

Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  


<210>  1631
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (30)..(30)
<223>  C-terminal amidation

<400>  1631

His Ser Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu Asp Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Met Asn Thr Asn 
            20                  25                  30  


<210>  1632
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  Xaa is Phe, hydroxyl-Phe, Gly, hydroxyl-Gly, Ala, Cys, Ser, Lys, 
       Glu, dehydro-Val, Pro, d-Pro, AIB, 1-aminocyclohexanecarboxylic 
       acid, 1-aminocyclopropanecarboxylic acid, N-Me-AIB, 
       alpha-alpha-diethyl-Gly, hydroxyl-AIB, or d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Pro, d-Pro, N-methyl-Gly, N-hexyl-Gly, 
       Azetidine-2-carboxylic acid, N-methyl-Ala, or N-methyl-Phe

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is His, d-His, Ala, or N-methyl-His

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  C-terminal amidation

<400>  1632

Xaa Xaa Xaa Ser Arg Gly Thr Phe 
1               5               


<210>  1633
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Sar

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Covalently bound to PEG via 40kDa maleimide

<400>  1633

Lys Xaa His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1634
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Sar

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Cys residue linked to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  C-terminal amidation

<400>  1634

Lys Xaa His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Asn 
            20                  25                  30          


<210>  1635
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is Sar

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is DMIA

<220>
<221>  MISC_FEATURE
<222>  (18)..(22)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Covalently bound to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  1635

Lys Xaa Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1636
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-hexyl-Gly

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Covalently bound to 40K PEG via thioether

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  AMIDATION

<400>  1636

Lys Gly His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1637
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-hexyl-Gly

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Cys residue linked to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  C-terminal amidation

<400>  1637

Lys Gly His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Asn 
            20                  25                  30          


<210>  1638
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-hexyl-Gly

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is DMIA

<220>
<221>  MISC_FEATURE
<222>  (18)..(22)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Covalently bound to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  1638

Lys Gly Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1639
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-methyl-Phe

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Covalently bound to 40kDa PEG via maleimide

<400>  1639

Lys Phe His Xaa Glu Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1640
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-methyl-Phe

<220>
<221>  MOD_RES
<222>  (4)..(4)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Cys residue linked to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  C-terminal amidation

<400>  1640

Lys Phe His Xaa Gln Gly Thr Phe Thr Ser Asp Tyr Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Met Asn Thr Asn 
            20                  25                  30          


<210>  1641
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  d-Lys

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  N-methyl-Phe

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  Xaa is DMIA

<220>
<221>  MISC_FEATURE
<222>  (18)..(22)
<223>  Lactam ring between side chains of amino acids

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  Covalently bound to 40kDa PEG via maleimide

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  C-terminal amidation

<400>  1641

Lys Phe Xaa Ser Gln Gly Thr Phe Thr Ser Asp Lys Ser Lys Tyr Leu 
1               5                   10                  15      


Asp Glu Arg Arg Ala Lys Asp Phe Val Cys Trp Leu Met Asn Thr 
            20                  25                  30      


<210>  1642
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1642

His Ala Asp Gly Val Phe Thr Ser Asp Phe Ser Lys Leu Leu Gly Gln 
1               5                   10                  15      


Leu Ser Ala Lys Lys Tyr Leu Glu Ser Leu Met 
            20                  25          


<210>  1643
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  1643

Lys Arg Asn Arg 
1               


<210>  1644
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  1644

Met Arg Ala Leu Thr Leu Leu Ala Leu Leu Ala Leu Ala Ala Leu Cys 
1               5                   10                  15      


Ile Ala Gly Gln Ala Gly Ala Lys Pro Ser Gly Ala Glu Ser Ser Lys 
            20                  25                  30          


Gly Ala Ala Phe Val Ser Lys Gln Glu Gly Ser Glu Val Val Lys Arg 
        35                  40                  45              


Pro Arg Arg Tyr Leu Tyr Gln Trp Leu Gly Ala Pro Val Pro Tyr Pro 
    50                  55                  60                  


Asp Pro Leu Glu Pro Arg Arg Glu Val Cys Glu Leu Asn Pro Asp Cys 
65                  70                  75                  80  


Asp Glu Leu Ala Asp His Ile Gly Phe Gln Glu Ala Tyr Arg Arg Phe 
                85                  90                  95      


Tyr Gly Pro Val 
            100 


<210>  1645
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  1645

Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp Phe 
1               5                   10                  15      


Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala Pro 
            20                  25                  30          


<210>  1646
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1646

Lys Cys Asn Thr Ala Thr Cys Ala Thr Gln Arg Leu Ala Asn Phe Leu 
1               5                   10                  15      


Val His Ser Ser Asn Asn Phe Gly Ala Ile Leu Ser Ser Thr Asn Val 
            20                  25                  30          


Gly Ser Asn Thr Tyr 
        35          


<210>  1647
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1647

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1648
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1648

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1649
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Phe

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D-Asp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-Tyr

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  D-Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  D-Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  D-Trp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1649

Ala Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1650
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1650

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1651
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of beta-estradiol via ether 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1651

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1652
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of beta-estradiol via ether 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1652

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1653
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Phe

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D-Asp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-Tyr

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  D-Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  D-Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  D-Trp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of beta-estradiol via ether 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1653

Ala Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1654
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of beta-estradiol via ether 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1654

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1655
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via ester 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1655

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1656
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via ester 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1656

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1657
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Phe

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D-Asp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-Tyr

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  D-Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  D-Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  D-Trp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via ester 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1657

Ala Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1658
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of 17-acetyl-beta estradiol via 
       ester linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1658

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1659
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (1)..(1)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (3)..(3)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (5)..(5)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (6)..(6)
<223>  D-Phe

<220>
<221>  MOD_RES
<222>  (7)..(7)
<223>  D-Thr

<220>
<221>  MOD_RES
<222>  (8)..(8)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (9)..(9)
<223>  D-Asp

<220>
<221>  MOD_RES
<222>  (10)..(10)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (11)..(11)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (12)..(12)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (13)..(13)
<223>  D-Tyr

<220>
<221>  MOD_RES
<222>  (14)..(14)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (15)..(15)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (17)..(17)
<223>  D-Gln

<220>
<221>  MOD_RES
<222>  (18)..(18)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (19)..(19)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (20)..(20)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (21)..(21)
<223>  D-Glu

<220>
<221>  MOD_RES
<222>  (22)..(22)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (23)..(23)
<223>  D-Ile

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (25)..(25)
<223>  D-Trp

<220>
<221>  MOD_RES
<222>  (26)..(26)
<223>  D-Leu

<220>
<221>  MOD_RES
<222>  (27)..(27)
<223>  D-Val

<220>
<221>  MOD_RES
<222>  (28)..(28)
<223>  D-Lys

<220>
<221>  MOD_RES
<222>  (31)..(31)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (32)..(32)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (33)..(33)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (35)..(35)
<223>  D-Ala

<220>
<221>  MOD_RES
<222>  (36)..(36)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (37)..(37)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (38)..(38)
<223>  D-Pro

<220>
<221>  MOD_RES
<222>  (39)..(39)
<223>  D-Ser

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of 17-acetyl-beta estradiol via 
       ester linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1659

Ala Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 
1               5                   10                  15      


Gln Ala Ala Lys Glu Ala Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1660
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (24)..(24)
<223>  Covalently bound to 40kDa PEG via thioether

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of cholesterol via amide linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1660

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Cys Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1661
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of cholesterol via amide linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1661

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1662
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of estradiol via hydrazone 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1662

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1663
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via carbamate 
       disulfide linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1663

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1664
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is Beta, beta-dimethyl cysteine

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of estradiol via carbamate 
       disulfide linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1664

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1665
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via 
       diaminoethane-Phe-Lys linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1665

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1666
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of estrone via ester linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1666

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1667
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via carbamate 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1667

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1668
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of beta-estradiol via 
       diaminoethane-Phe-Lys paraaminobenzyl alcohol linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1668

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1669
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 17-position of dexamethasone via hydrazone 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1669

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1670
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of dexamethasone via carbamate 
       linkage

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1670

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1671
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of dexamethasone via carbamate 
       linkage

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1671

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Lys 
        35                  40  


<210>  1672
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of dexamethasone via disulfide 
       linkage

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1672

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Cys 
        35                  40  


<210>  1673
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is Penicillamine

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of dexamethasone via disulfide 
       linkage

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1673

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


<210>  1674
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MOD_RES
<222>  (2)..(2)
<223>  Xaa is AIB

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Xaa is homocysteine

<220>
<221>  MOD_RES
<222>  (40)..(40)
<223>  Covalently bound to 3-position of dexamethasone via disulfide 
       linkage

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  C-terminal amidation

<400>  1674

His Xaa Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Glu 
1               5                   10                  15      


Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Gly Pro Ser 
            20                  25                  30          


Ser Gly Ala Pro Pro Pro Ser Xaa 
        35                  40  


