                         SEQUENCE LISTING

<110>  Clarient Diagnostic Services, Inc.
 
<120>  Detection of ABL Mutant By Allele-Specific Amplification

<130>  PC11119

<150>  US 61/560,866
<151>  2011-11-17

<150>  GB 1121869.0
<151>  2011-12-20

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  130
<212>  DNA
<213>  Homo sapiens

<400>  1
taatatattt cttcatgaag acctcacagt aaaaataggt gattttggtc tagctacagt       60

gaaatctcga tggagtgggt cccatcagtt tgaacagttg tctggatcca ttttgtggat      120

ggcaccagaa                                                             130


<210>  2
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  2
cactccatcg agatttca                                                     18


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  3
ccactccatc gagatttct                                                    19


<210>  4
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  4
atatttcttc atgaagacct cacagta                                           27


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Probe

<400>  5
aggtgatttt ggtctagcta c                                                 21


<210>  6
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  6
ctggtgcagc tccttggg                                                     18


<210>  7
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  7
ccgtaggtca tgaactcag                                                    19


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  8
ccgtaggtca tgaactcaa                                                    19


<210>  9
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  PCR Probe

<400>  9
ccccgttcta tatcatc                                                      17


<210>  10
<211>  744
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Ala Leu Ser Gly Gly Gly Gly Gly Gly Ala Glu Pro Gly Gln 
1               5                   10                  15      


Ala Leu Phe Asn Gly Asp Met Glu Pro Glu Ala Gly Ala Gly Ala Gly 
            20                  25                  30          


Ala Ala Ala Ser Ser Ala Ala Asp Pro Ala Ile Pro Glu Glu Val Trp 
        35                  40                  45              


Asn Ile Lys Gln Met Ile Lys Leu Thr Gln Glu His Ile Glu Ala Leu 
    50                  55                  60                  


Leu Asp Lys Phe Gly Gly Glu His Asn Pro Pro Ser Ile Tyr Leu Glu 
65                  70                  75                  80  


Ala Tyr Glu Glu Tyr Thr Ser Lys Leu Asp Ala Leu Gln Gln Arg Glu 
                85                  90                  95      


Gln Gln Leu Leu Glu Ser Leu Gly Asn Gly Thr Asp Phe Ser Val Ser 
            100                 105                 110         


Ser Ser Ala Ser Met Asp Thr Val Thr Ser Ser Ser Ser Ser Ser Leu 
        115                 120                 125             


Ser Val Leu Pro Ser Ser Leu Ser Val Phe Gln Asn Pro Thr Asp Val 
    130                 135                 140                 


Ala Arg Ser Asn Pro Lys Ser Pro Gln Lys Pro Ile Val Arg Val Phe 
145                 150                 155                 160 


Leu Pro Asn Lys Gln Arg Thr Val Val Pro Ala Arg Cys Gly Val Thr 
                165                 170                 175     


Val Arg Asp Ser Leu Lys Lys Ala Leu Met Met Arg Gly Leu Ile Pro 
            180                 185                 190         


Glu Cys Cys Ala Val Tyr Arg Ile Gln Asp Gly Glu Lys Lys Pro Ile 
        195                 200                 205             


Gly Trp Asp Thr Asp Ile Ser Trp Leu Thr Gly Glu Glu Leu His Val 
    210                 215                 220                 


Glu Val Leu Glu Asn Val Pro Leu Thr Thr His Asn Phe Val Arg Lys 
225                 230                 235                 240 


Thr Phe Phe Thr Leu Ala Phe Cys Asp Phe Cys Arg Lys Leu Leu Phe 
                245                 250                 255     


Gln Gly Phe Arg Cys Gln Thr Cys Gly Tyr Lys Phe His Gln Arg Cys 
            260                 265                 270         


Ser Thr Glu Val Pro Leu Met Cys Val Asn Tyr Asp Gln Leu Asp Leu 
        275                 280                 285             


Leu Phe Val Ser Lys Phe Phe Glu His His Pro Ile Pro Gln Glu Glu 
    290                 295                 300                 


Ala Ser Leu Ala Glu Thr Ala Leu Thr Ser Gly Ser Ser Pro Ser Ala 
305                 310                 315                 320 


Pro Ala Ser Asp Ser Ile Gly Pro Gln Ile Leu Thr Ser Pro Ser Pro 
                325                 330                 335     


Ser Lys Ser Ile Pro Ile Pro Gln Pro Phe Arg Pro Ala Asp Glu Asp 
            340                 345                 350         


His Arg Asn Gln Phe Gly Gln Arg Asp Arg Ser Ser Ser Ala Pro Asn 
        355                 360                 365             


Val His Ile Asn Thr Ile Glu Pro Val Asn Ile Asp Asp Leu Ile Arg 
    370                 375                 380                 


Asp Gln Gly Phe Arg Gly Asp Gly Gly Ser Thr Thr Gly Leu Ser Ala 
385                 390                 395                 400 


Thr Pro Pro Ala Ser Leu Pro Gly Ser Leu Thr Asn Val Lys Ala Leu 
                405                 410                 415     


Gln Lys Ser Pro Gly Pro Gln Arg Glu Arg Lys Ser Ser Ser Ser Ser 
            420                 425                 430         


Glu Asp Arg Asn Arg Met Lys Thr Leu Gly Arg Arg Asp Ser Ser Asp 
        435                 440                 445             


Asp Trp Glu Ile Pro Asp Gly Gln Ile Thr Val Gly Gln Arg Ile Gly 
    450                 455                 460                 


Ser Gly Ser Phe Gly Thr Val Tyr Lys Gly Lys Trp His Gly Asp Val 
465                 470                 475                 480 


Ala Val Lys Met Leu Asn Val Thr Ala Pro Thr Pro Gln Gln Leu Gln 
                485                 490                 495     


Ala Phe Lys Asn Glu Val Gly Val Leu Arg Lys Thr Arg His Val Asn 
            500                 505                 510         


Ile Leu Leu Phe Met Gly Tyr Ser Thr Lys Pro Gln Leu Ala Ile Val 
        515                 520                 525             


Thr Gln Trp Cys Glu Gly Ser Ser Leu Tyr His His Leu His Ile Ile 
    530                 535                 540                 


Glu Thr Lys Phe Glu Met Ile Lys Leu Ile Asp Ile Ala Arg Gln Thr 
545                 550                 555                 560 


Ala Gln Gly Met Asp Tyr Leu His Ala Lys Ser Ile Ile His Arg Asp 
                565                 570                 575     


Leu Lys Ser Asn Asn Ile Phe Leu His Glu Asp Leu Thr Val Lys Ile 
            580                 585                 590         


Gly Asp Phe Gly Leu Ala Thr Val Lys Ser Arg Trp Ser Gly Ser His 
        595                 600                 605             


Gln Phe Glu Gln Leu Ser Gly Ser Ile Leu Trp Met Ala Pro Glu Val 
    610                 615                 620                 


Ile Arg Met Gln Asp Lys Asn Pro Tyr Ser Phe Gln Ser Asp Val Tyr 
625                 630                 635                 640 


Ala Phe Gly Ile Val Leu Tyr Glu Leu Met Thr Gly Gln Leu Pro Tyr 
                645                 650                 655     


Ser Asn Ile Asn Asn Arg Asp Gln Ile Ile Phe Met Val Gly Arg Gly 
            660                 665                 670         


Tyr Leu Ser Pro Asp Leu Ser Lys Val Arg Ser Asn Cys Pro Lys Ala 
        675                 680                 685             


Met Lys Arg Leu Met Ala Glu Cys Leu Lys Lys Lys Arg Asp Glu Arg 
    690                 695                 700                 


Pro Leu Phe Pro Gln Ile Leu Ala Ser Ile Glu Leu Leu Ala Glu Asp 
705                 710                 715                 720 


Phe Ser Leu Tyr Ala Cys Ala Ser Pro Lys Thr Pro Ile Gln Ala Gly 
                725                 730                 735     


Gly Tyr Gly Ala Phe Pro Val His 
            740                 


<210>  11
<211>  1130
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Leu Glu Ile Cys Leu Lys Leu Val Gly Cys Lys Ser Lys Lys Gly 
1               5                   10                  15      


Leu Ser Ser Ser Ser Ser Cys Tyr Leu Glu Glu Ala Leu Gln Arg Pro 
            20                  25                  30          


Val Ala Ser Asp Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp 
        35                  40                  45              


Asn Ser Lys Glu Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn 
    50                  55                  60                  


Leu Phe Val Ala Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Ile Thr Lys Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn 
                85                  90                  95      


Gly Glu Trp Cys Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro 
            100                 105                 110         


Ser Asn Tyr Ile Thr Pro Val Asn Ser Leu Glu Lys His Ser Trp Tyr 
        115                 120                 125             


His Gly Pro Val Ser Arg Asn Ala Ala Glu Tyr Leu Leu Ser Ser Gly 
    130                 135                 140                 


Ile Asn Gly Ser Phe Leu Val Arg Glu Ser Glu Ser Ser Pro Gly Gln 
145                 150                 155                 160 


Arg Ser Ile Ser Leu Arg Tyr Glu Gly Arg Val Tyr His Tyr Arg Ile 
                165                 170                 175     


Asn Thr Ala Ser Asp Gly Lys Leu Tyr Val Ser Ser Glu Ser Arg Phe 
            180                 185                 190         


Asn Thr Leu Ala Glu Leu Val His His His Ser Thr Val Ala Asp Gly 
        195                 200                 205             


Leu Ile Thr Thr Leu His Tyr Pro Ala Pro Lys Arg Asn Lys Pro Thr 
    210                 215                 220                 


Val Tyr Gly Val Ser Pro Asn Tyr Asp Lys Trp Glu Met Glu Arg Thr 
225                 230                 235                 240 


Asp Ile Thr Met Lys His Lys Leu Gly Gly Gly Gln Tyr Gly Glu Val 
                245                 250                 255     


Tyr Glu Gly Val Trp Lys Lys Tyr Ser Leu Thr Val Ala Val Lys Thr 
            260                 265                 270         


Leu Lys Glu Asp Thr Met Glu Val Glu Glu Phe Leu Lys Glu Ala Ala 
        275                 280                 285             


Val Met Lys Glu Ile Lys His Pro Asn Leu Val Gln Leu Leu Gly Val 
    290                 295                 300                 


Cys Thr Arg Glu Pro Pro Phe Tyr Ile Ile Thr Glu Phe Met Thr Tyr 
305                 310                 315                 320 


Gly Asn Leu Leu Asp Tyr Leu Arg Glu Cys Asn Arg Gln Glu Val Asn 
                325                 330                 335     


Ala Val Val Leu Leu Tyr Met Ala Thr Gln Ile Ser Ser Ala Met Glu 
            340                 345                 350         


Tyr Leu Glu Lys Lys Asn Phe Ile His Arg Asp Leu Ala Ala Arg Asn 
        355                 360                 365             


Cys Leu Val Gly Glu Asn His Leu Val Lys Val Ala Asp Phe Gly Leu 
    370                 375                 380                 


Ser Arg Leu Met Thr Gly Asp Thr Tyr Thr Ala His Ala Gly Ala Lys 
385                 390                 395                 400 


Phe Pro Ile Lys Trp Thr Ala Pro Glu Ser Leu Ala Tyr Asn Lys Phe 
                405                 410                 415     


Ser Ile Lys Ser Asp Val Trp Ala Phe Gly Val Leu Leu Trp Glu Ile 
            420                 425                 430         


Ala Thr Tyr Gly Met Ser Pro Tyr Pro Gly Ile Asp Leu Ser Gln Val 
        435                 440                 445             


Tyr Glu Leu Leu Glu Lys Asp Tyr Arg Met Glu Arg Pro Glu Gly Cys 
    450                 455                 460                 


Pro Glu Lys Val Tyr Glu Leu Met Arg Ala Cys Trp Gln Trp Asn Pro 
465                 470                 475                 480 


Ser Asp Arg Pro Ser Phe Ala Glu Ile His Gln Ala Phe Glu Thr Met 
                485                 490                 495     


Phe Gln Glu Ser Ser Ile Ser Asp Glu Val Glu Lys Glu Leu Gly Lys 
            500                 505                 510         


Gln Gly Val Arg Gly Ala Val Ser Thr Leu Leu Gln Ala Pro Glu Leu 
        515                 520                 525             


Pro Thr Lys Thr Arg Thr Ser Arg Arg Ala Ala Glu His Arg Asp Thr 
    530                 535                 540                 


Thr Asp Val Pro Glu Met Pro His Ser Lys Gly Gln Gly Glu Ser Asp 
545                 550                 555                 560 


Pro Leu Asp His Glu Pro Ala Val Ser Pro Leu Leu Pro Arg Lys Glu 
                565                 570                 575     


Arg Gly Pro Pro Glu Gly Gly Leu Asn Glu Asp Glu Arg Leu Leu Pro 
            580                 585                 590         


Lys Asp Lys Lys Thr Asn Leu Phe Ser Ala Leu Ile Lys Lys Lys Lys 
        595                 600                 605             


Lys Thr Ala Pro Thr Pro Pro Lys Arg Ser Ser Ser Phe Arg Glu Met 
    610                 615                 620                 


Asp Gly Gln Pro Glu Arg Arg Gly Ala Gly Glu Glu Glu Gly Arg Asp 
625                 630                 635                 640 


Ile Ser Asn Gly Ala Leu Ala Phe Thr Pro Leu Asp Thr Ala Asp Pro 
                645                 650                 655     


Ala Lys Ser Pro Lys Pro Ser Asn Gly Ala Gly Val Pro Asn Gly Ala 
            660                 665                 670         


Leu Arg Glu Ser Gly Gly Ser Gly Phe Arg Ser Pro His Leu Trp Lys 
        675                 680                 685             


Lys Ser Ser Thr Leu Thr Ser Ser Arg Leu Ala Thr Gly Glu Glu Glu 
    690                 695                 700                 


Gly Gly Gly Ser Ser Ser Lys Arg Phe Leu Arg Ser Cys Ser Ala Ser 
705                 710                 715                 720 


Cys Val Pro His Gly Ala Lys Asp Thr Glu Trp Arg Ser Val Thr Leu 
                725                 730                 735     


Pro Arg Asp Leu Gln Ser Thr Gly Arg Gln Phe Asp Ser Ser Thr Phe 
            740                 745                 750         


Gly Gly His Lys Ser Glu Lys Pro Ala Leu Pro Arg Lys Arg Ala Gly 
        755                 760                 765             


Glu Asn Arg Ser Asp Gln Val Thr Arg Gly Thr Val Thr Pro Pro Pro 
    770                 775                 780                 


Arg Leu Val Lys Lys Asn Glu Glu Ala Ala Asp Glu Val Phe Lys Asp 
785                 790                 795                 800 


Ile Met Glu Ser Ser Pro Gly Ser Ser Pro Pro Asn Leu Thr Pro Lys 
                805                 810                 815     


Pro Leu Arg Arg Gln Val Thr Val Ala Pro Ala Ser Gly Leu Pro His 
            820                 825                 830         


Lys Glu Glu Ala Gly Lys Gly Ser Ala Leu Gly Thr Pro Ala Ala Ala 
        835                 840                 845             


Glu Pro Val Thr Pro Thr Ser Lys Ala Gly Ser Gly Ala Pro Gly Gly 
    850                 855                 860                 


Thr Ser Lys Gly Pro Ala Glu Glu Ser Arg Val Arg Arg His Lys His 
865                 870                 875                 880 


Ser Ser Glu Ser Pro Gly Arg Asp Lys Gly Lys Leu Ser Arg Leu Lys 
                885                 890                 895     


Pro Ala Pro Pro Pro Pro Pro Ala Ala Ser Ala Gly Lys Ala Gly Gly 
            900                 905                 910         


Lys Pro Ser Gln Ser Pro Ser Gln Glu Ala Ala Gly Glu Ala Val Leu 
        915                 920                 925             


Gly Ala Lys Thr Lys Ala Thr Ser Leu Val Asp Ala Val Asn Ser Asp 
    930                 935                 940                 


Ala Ala Lys Pro Ser Gln Pro Gly Glu Gly Leu Lys Lys Pro Val Leu 
945                 950                 955                 960 


Pro Ala Thr Pro Lys Pro Gln Ser Ala Lys Pro Ser Gly Thr Pro Ile 
                965                 970                 975     


Ser Pro Ala Pro Val Pro Ser Thr Leu Pro Ser Ala Ser Ser Ala Leu 
            980                 985                 990         


Ala Gly Asp Gln Pro Ser Ser Thr  Ala Phe Ile Pro Leu  Ile Ser Thr 
        995                 1000                 1005             


Arg Val  Ser Leu Arg Lys Thr  Arg Gln Pro Pro Glu  Arg Ile Ala 
    1010                 1015                 1020             


Ser Gly  Ala Ile Thr Lys Gly  Val Val Leu Asp Ser  Thr Glu Ala 
    1025                 1030                 1035             


Leu Cys  Leu Ala Ile Ser Arg  Asn Ser Glu Gln Met  Ala Ser His 
    1040                 1045                 1050             


Ser Ala  Val Leu Glu Ala Gly  Lys Asn Leu Tyr Thr  Phe Cys Val 
    1055                 1060                 1065             


Ser Tyr  Val Asp Ser Ile Gln  Gln Met Arg Asn Lys  Phe Ala Phe 
    1070                 1075                 1080             


Arg Glu  Ala Ile Asn Lys Leu  Glu Asn Asn Leu Arg  Glu Leu Gln 
    1085                 1090                 1095             


Ile Cys  Pro Ala Thr Ala Gly  Ser Gly Pro Ala Ala  Thr Gln Asp 
    1100                 1105                 1110             


Phe Ser  Lys Leu Leu Ser Ser  Val Lys Glu Ile Ser  Asp Ile Val 
    1115                 1120                 1125             


Gln Arg  
    1130 


<210>  12
<211>  5388
<212>  DNA
<213>  Homo sapiens

<400>  12
aaaatgttgg agatctgcct gaagctggtg ggctgcaaat ccaagaaggg gctgtcctcg       60

tcctccagct gttatctgga agaagccctt cagcggccag tagcatctga ctttgagcct      120

cagggtctga gtgaagccgc tcgttggaac tccaaggaaa accttctcgc tggacccagt      180

gaaaatgacc ccaacctttt cgttgcactg tatgattttg tggccagtgg agataacact      240

ctaagcataa ctaaaggtga aaagctccgg gtcttaggct ataatcacaa tggggaatgg      300

tgtgaagccc aaaccaaaaa tggccaaggc tgggtcccaa gcaactacat cacgccagtc      360

aacagtctgg agaaacactc ctggtaccat gggcctgtgt cccgcaatgc cgctgagtat      420

ctgctgagca gcgggatcaa tggcagcttc ttggtgcgtg agagtgagag cagtcctggc      480

cagaggtcca tctcgctgag atacgaaggg agggtgtacc attacaggat caacactgct      540

tctgatggca agctctacgt ctcctccgag agccgcttca acaccctggc cgagttggtt      600

catcatcatt caacggtggc cgacgggctc atcaccacgc tccattatcc agccccaaag      660

cgcaacaagc ccactgtcta tggtgtgtcc cccaactacg acaagtggga gatggaacgc      720

acggacatca ccatgaagca caagctgggc gggggccagt acggggaggt gtacgagggc      780

gtgtggaaga aatacagcct gacggtggcc gtgaagacct tgaaggagga caccatggag      840

gtggaagagt tcttgaaaga agctgcagtc atgaaagaga tcaaacaccc taacctggtg      900

cagctccttg gggtctgcac ccgggagccc ccgttctata tcatcactga gttcatgacc      960

tacgggaacc tcctggacta cctgagggag tgcaaccggc aggaggtgaa cgccgtggtg     1020

ctgctgtaca tggccactca gatctcgtca gccatggagt acctggagaa gaaaaacttc     1080

atccacagag atcttgctgc ccgaaactgc ctggtagggg agaaccactt ggtgaaggta     1140

gctgattttg gcctgagcag gttgatgaca ggggacacct acacagccca tgctggagcc     1200

aagttcccca tcaaatggac tgcacccgag agcctggcct acaacaagtt ctccatcaag     1260

tccgacgtct gggcatttgg agtattgctt tgggaaattg ctacctatgg catgtcccct     1320

tacccgggaa ttgacctgtc ccaggtgtat gagctgctag agaaggacta ccgcatggag     1380

cgcccagaag gctgcccaga gaaggtctat gaactcatgc gagcatgttg gcagtggaat     1440

ccctctgacc ggccctcctt tgctgaaatc caccaagcct ttgaaacaat gttccaggaa     1500

tccagtatct cagacgaagt ggaaaaggag ctggggaaac aaggcgtccg tggggctgtg     1560

agtaccttgc tgcaggcccc agagctgccc accaagacga ggacctccag gagagctgca     1620

gagcacagag acaccactga cgtgcctgag atgcctcact ccaagggcca gggagagagc     1680

gatcctctgg accatgagcc tgccgtgtct ccattgctcc ctcgaaaaga gcgaggtccc     1740

ccggagggcg gcctgaatga agatgagcgc cttctcccca aagacaaaaa gaccaacttg     1800

ttcagcgcct tgatcaagaa gaagaagaag acagccccaa cccctcccaa acgcagcagc     1860

tccttccggg agatggacgg ccagccggag cgcagagggg ccggcgagga agagggccga     1920

gacatcagca acggggcact ggctttcacc cccttggaca cagctgaccc agccaagtcc     1980

ccaaagccca gcaatggggc tggggtcccc aatggagccc tccgggagtc cgggggctca     2040

ggcttccggt ctccccacct gtggaagaag tccagcacgc tgaccagcag ccgcctagcc     2100

accggcgagg aggagggcgg tggcagctcc agcaagcgct tcctgcgctc ttgctccgcc     2160

tcctgcgttc cccatggggc caaggacacg gagtggaggt cagtcacgct gcctcgggac     2220

ttgcagtcca cgggaagaca gtttgactcg tccacatttg gagggcacaa aagtgagaag     2280

ccggctctgc ctcggaagag ggcaggggag aacaggtctg accaggtgac ccgaggcaca     2340

gtaacgcctc cccccaggct ggtgaaaaag aatgaggaag ctgctgatga ggtcttcaaa     2400

gacatcatgg agtccagccc gggctccagc ccgcccaacc tgactccaaa acccctccgg     2460

cggcaggtca ccgtggcccc tgcctcgggc ctcccccaca aggaagaagc tggaaagggc     2520

agtgccttag ggacccctgc tgcagctgag ccagtgaccc ccaccagcaa agcaggctca     2580

ggtgcaccag ggggcaccag caagggcccc gccgaggagt ccagagtgag gaggcacaag     2640

cactcctctg agtcgccagg gagggacaag gggaaattgt ccaggctcaa acctgccccg     2700

ccgcccccac cagcagcctc tgcagggaag gctggaggaa agccctcgca gagcccgagc     2760

caggaggcgg ccggggaggc agtcctgggc gcaaagacaa aagccacgag tctggttgat     2820

gctgtgaaca gtgacgctgc caagcccagc cagccgggag agggcctcaa aaagcccgtg     2880

ctcccggcca ctccaaagcc acagtccgcc aagccgtcgg ggacccccat cagcccagcc     2940

cccgttccct ccacgttgcc atcagcatcc tcggccctgg caggggacca gccgtcttcc     3000

accgccttca tccctctcat atcaacccga gtgtctcttc ggaaaacccg ccagcctcca     3060

gagcggatcg ccagcggcgc catcaccaag ggcgtggtcc tggacagcac cgaggcgctg     3120

tgcctcgcca tctctaggaa ctccgagcag atggccagcc acagcgcagt gctggaggcc     3180

ggcaaaaacc tctacacgtt ctgcgtgagc tatgtggatt ccatccagca aatgaggaac     3240

aagtttgcct tccgagaggc catcaacaaa ctggagaata atctccggga gcttcagatc     3300

tgcccggcga cagcaggcag tggtccagcg gccactcagg acttcagcaa gctcctcagt     3360

tcggtgaagg aaatcagtga catagtgcag aggtagcagc agtcaggggt caggtgtcag     3420

gcccgtcgga gctgcctgca gcacatgcgg gctcgcccat acccgtgaca gtggctgaca     3480

agggactagt gagtcagcac cttggcccag gagctctgcg ccaggcagag ctgagggccc     3540

tgtggagtcc agctctacta cctacgtttg caccgcctgc cctcccgcac cttcctcctc     3600

cccgctccgt ctctgtcctc gaattttatc tgtggagttc ctgctccgtg gactgcagtc     3660

ggcatgccag gacccgccag ccccgctccc acctagtgcc ccagactgag ctctccaggc     3720

caggtgggaa cggctgatgt ggactgtctt tttcattttt ttctctctgg agcccctcct     3780

cccccggctg ggcctccttc ttccacttct ccaagaatgg aagcctgaac tgaggccttg     3840

tgtgtcaggc cctctgcctg cactccctgg ccttgcccgt cgtgtgctga agacatgttt     3900

caagaaccgc atttcgggaa gggcatgcac gggcatgcac acggctggtc actctgccct     3960

ctgctgctgc ccggggtggg gtgcactcgc catttcctca cgtgcaggac agctcttgat     4020

ttgggtggaa aacagggtgc taaagccaac cagcctttgg gtcctgggca ggtgggagct     4080

gaaaaggatc gaggcatggg gcatgtcctt tccatctgtc cacatcccca gagcccagct     4140

cttgctctct tgtgacgtgc actgtgaatc ctggcaagaa agcttgagtc tcaagggtgg     4200

caggtcactg tcactgccga catccctccc ccagcagaat ggaggcaggg gacaagggag     4260

gcagtggcta gtggggtgaa cagctggtgc caaatagccc cagactgggc ccaggcaggt     4320

ctgcaagggc ccagagtgaa ccgtcctttc acacatctgg gtgccctgaa agggcccttc     4380

ccctccccca ctcctctaag acaaagtaga ttcttacaag gccctttcct ttggaacaag     4440

acagccttca cttttctgag ttcttgaagc atttcaaagc cctgcctctg tgtagccgcc     4500

ctgagagaga atagagctgc cactgggcac ctgcgcacag gtgggaggaa agggcctggc     4560

cagtcctggt cctggctgca ctcttgaact gggcgaatgt cttatttaat taccgtgagt     4620

gacatagcct catgttctgt gggggtcatc agggagggtt aggaaaacca caaacggagc     4680

ccctgaaagc ctcacgtatt tcacagagca cgcctgccat cttctccccg aggctgcccc     4740

aggccggagc ccagatacgg gggctgtgac tctgggcagg gacccggggt ctcctggacc     4800

ttgacagagc agctaactcc gagagcagtg ggcaggtggc cgcccctgag gcttcacgcc     4860

gggagaagcc accttcccac cccttcatac cgcctcgtgc cagcagcctc gcacaggccc     4920

tagctttacg ctcatcacct aaacttgtac tttatttttc tgatagaaat ggtttcctct     4980

ggatcgtttt atgcggttct tacagcacat cacctctttg cccccgacgg ctgtgacgca     5040

gccggaggga ggcactagtc accgacagcg gccttgaaga cagagcaaag cgcccaccca     5100

ggtcccccga ctgcctgtct ccatgaggta ctggtccctt ccttttgtta acgtgatgtg     5160

ccactatatt ttacacgtat ctcttggtat gcatctttta tagacgctct tttctaagtg     5220

gcgtgtgcat agcgtcctgc cctgccccct cgggggcctg tggtggctcc ccctctgctt     5280

ctcggggtcc agtgcatttt gtttctgtat atgattctct gtggtttttt ttgaatccaa     5340

atctgtcctc tgtagtattt tttaaataaa tcagtgttta cattagaa                  5388


<210>  13
<211>  2006
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Val Asp Pro Val Gly Phe Ala Glu Ala Trp Lys Ala Gln Phe Pro 
1               5                   10                  15      


Asp Ser Glu Pro Pro Arg Met Glu Leu Arg Ser Val Gly Asp Ile Glu 
            20                  25                  30          


Gln Glu Leu Glu Arg Cys Lys Ala Ser Ile Arg Arg Leu Glu Gln Glu 
        35                  40                  45              


Val Asn Gln Glu Arg Phe Arg Met Ile Tyr Leu Gln Thr Leu Leu Ala 
    50                  55                  60                  


Lys Glu Lys Lys Ser Tyr Asp Arg Gln Arg Trp Gly Phe Arg Arg Ala 
65                  70                  75                  80  


Ala Gln Ala Pro Asp Gly Ala Ser Glu Pro Arg Ala Ser Ala Ser Arg 
                85                  90                  95      


Pro Gln Pro Ala Pro Ala Asp Gly Ala Asp Pro Pro Pro Ala Glu Glu 
            100                 105                 110         


Pro Glu Ala Arg Pro Asp Gly Glu Gly Ser Pro Gly Lys Ala Arg Pro 
        115                 120                 125             


Gly Thr Ala Arg Arg Pro Gly Ala Ala Ala Ser Gly Glu Arg Asp Asp 
    130                 135                 140                 


Arg Gly Pro Pro Ala Ser Val Ala Ala Leu Arg Ser Asn Phe Glu Arg 
145                 150                 155                 160 


Ile Arg Lys Gly His Gly Gln Pro Gly Ala Asp Ala Glu Lys Pro Phe 
                165                 170                 175     


Tyr Val Asn Val Glu Phe His His Glu Arg Gly Leu Val Lys Val Asn 
            180                 185                 190         


Asp Lys Glu Val Ser Asp Arg Ile Ser Ser Leu Gly Ser Gln Ala Met 
        195                 200                 205             


Gln Met Glu Arg Lys Lys Ser Gln His Gly Ala Gly Ser Ser Val Gly 
    210                 215                 220                 


Asp Ala Ser Arg Pro Pro Tyr Arg Gly Arg Ser Ser Glu Ser Ser Cys 
225                 230                 235                 240 


Gly Val Asp Gly Asp Tyr Glu Asp Ala Glu Leu Asn Pro Arg Phe Leu 
                245                 250                 255     


Lys Asp Asn Leu Ile Asp Ala Asn Gly Gly Ser Arg Pro Pro Trp Pro 
            260                 265                 270         


Pro Leu Glu Tyr Gln Pro Tyr Gln Ser Ile Tyr Val Gly Gly Met Met 
        275                 280                 285             


Glu Gly Glu Gly Lys Gly Pro Leu Leu Arg Ser Gln Ser Thr Ser Glu 
    290                 295                 300                 


Gln Glu Lys Arg Leu Thr Trp Pro Arg Arg Ser Tyr Ser Pro Arg Ser 
305                 310                 315                 320 


Phe Glu Asp Cys Gly Gly Gly Tyr Thr Pro Asp Cys Ser Ser Asn Glu 
                325                 330                 335     


Asn Leu Thr Ser Ser Glu Glu Asp Phe Ser Ser Gly Gln Ser Ser Arg 
            340                 345                 350         


Val Ser Pro Ser Pro Thr Thr Tyr Arg Met Phe Arg Asp Lys Ser Arg 
        355                 360                 365             


Ser Pro Ser Gln Asn Ser Gln Gln Ser Phe Asp Ser Ser Ser Pro Pro 
    370                 375                 380                 


Thr Pro Gln Cys His Lys Arg His Arg His Cys Pro Val Val Val Ser 
385                 390                 395                 400 


Glu Ala Thr Ile Val Gly Val Arg Lys Thr Gly Gln Ile Trp Pro Asn 
                405                 410                 415     


Asp Gly Glu Gly Ala Phe His Gly Asp Ala Asp Gly Ser Phe Gly Thr 
            420                 425                 430         


Pro Pro Gly Tyr Gly Cys Ala Ala Asp Arg Ala Glu Glu Gln Arg Arg 
        435                 440                 445             


His Gln Asp Gly Leu Pro Tyr Ile Asp Asp Ser Pro Ser Ser Ser Pro 
    450                 455                 460                 


His Leu Ser Ser Lys Gly Arg Gly Ser Arg Asp Ala Leu Val Ser Gly 
465                 470                 475                 480 


Ala Leu Glu Ser Thr Lys Ala Ser Glu Leu Asp Leu Glu Lys Gly Leu 
                485                 490                 495     


Glu Met Arg Lys Trp Val Leu Ser Gly Ile Leu Ala Ser Glu Glu Thr 
            500                 505                 510         


Tyr Leu Ser His Leu Glu Ala Leu Leu Leu Pro Met Lys Pro Leu Lys 
        515                 520                 525             


Ala Ala Ala Thr Thr Ser Gln Pro Val Leu Thr Ser Gln Gln Ile Glu 
    530                 535                 540                 


Thr Ile Phe Phe Lys Val Pro Glu Leu Tyr Glu Ile His Lys Glu Phe 
545                 550                 555                 560 


Tyr Asp Gly Leu Phe Pro Arg Val Gln Gln Trp Ser His Gln Gln Arg 
                565                 570                 575     


Val Gly Asp Leu Phe Gln Lys Leu Ala Ser Gln Leu Gly Val Tyr Arg 
            580                 585                 590         


Ala Phe Val Asp Asn Tyr Gly Val Ala Met Glu Met Ala Glu Lys Cys 
        595                 600                 605             


Cys Gln Ala Asn Ala Gln Phe Ala Glu Ile Ser Glu Asn Leu Arg Ala 
    610                 615                 620                 


Arg Ser Asn Lys Asp Ala Lys Asp Pro Thr Thr Lys Asn Ser Leu Glu 
625                 630                 635                 640 


Thr Leu Leu Tyr Lys Pro Val Asp Arg Val Thr Arg Ser Thr Leu Val 
                645                 650                 655     


Leu His Asp Leu Leu Lys His Thr Pro Ala Ser His Pro Asp His Pro 
            660                 665                 670         


Leu Leu Gln Asp Ala Leu Arg Ile Ser Gln Asn Phe Leu Ser Ser Ile 
        675                 680                 685             


Asn Glu Glu Ile Thr Pro Arg Arg Gln Ser Met Thr Val Lys Lys Gly 
    690                 695                 700                 


Glu His Arg Gln Leu Leu Lys Asp Ser Phe Met Val Glu Leu Val Glu 
705                 710                 715                 720 


Gly Ala Arg Lys Leu Arg His Val Phe Leu Phe Thr Asp Leu Leu Leu 
                725                 730                 735     


Cys Thr Lys Leu Lys Lys Gln Ser Gly Gly Lys Thr Gln Gln Tyr Asp 
            740                 745                 750         


Cys Lys Trp Tyr Ile Pro Leu Thr Asp Leu Ser Phe Gln Met Val Asp 
        755                 760                 765             


Glu Leu Glu Ala Val Pro Asn Ile Pro Leu Val Pro Asp Glu Glu Leu 
    770                 775                 780                 


Asp Ala Leu Lys Ile Lys Ile Ser Gln Ile Lys Asn Asp Ile Gln Arg 
785                 790                 795                 800 


Glu Lys Arg Ala Asn Lys Gly Ser Lys Ala Thr Glu Arg Leu Lys Lys 
                805                 810                 815     


Lys Leu Ser Glu Gln Glu Ser Leu Leu Leu Leu Met Ser Pro Ser Met 
            820                 825                 830         


Ala Phe Arg Val His Ser Arg Asn Gly Lys Ser Tyr Thr Phe Leu Ile 
        835                 840                 845             


Ser Ser Asp Tyr Glu Arg Ala Glu Trp Arg Glu Asn Ile Arg Glu Gln 
    850                 855                 860                 


Gln Lys Lys Cys Phe Arg Ser Phe Ser Leu Thr Ser Val Glu Leu Gln 
865                 870                 875                 880 


Met Leu Thr Asn Ser Cys Val Lys Leu Gln Thr Val His Ser Ile Pro 
                885                 890                 895     


Leu Thr Ile Asn Lys Glu Glu Ala Leu Gln Arg Pro Val Ala Ser Asp 
            900                 905                 910         


Phe Glu Pro Gln Gly Leu Ser Glu Ala Ala Arg Trp Asn Ser Lys Glu 
        915                 920                 925             


Asn Leu Leu Ala Gly Pro Ser Glu Asn Asp Pro Asn Leu Phe Val Ala 
    930                 935                 940                 


Leu Tyr Asp Phe Val Ala Ser Gly Asp Asn Thr Leu Ser Ile Thr Lys 
945                 950                 955                 960 


Gly Glu Lys Leu Arg Val Leu Gly Tyr Asn His Asn Gly Glu Trp Cys 
                965                 970                 975     


Glu Ala Gln Thr Lys Asn Gly Gln Gly Trp Val Pro Ser Asn Tyr Ile 
            980                 985                 990         


Thr Pro Val Asn Ser Leu Glu Lys  His Ser Trp Tyr His  Gly Pro Val 
        995                 1000                 1005             


Ser Arg  Asn Ala Ala Glu Tyr  Leu Leu Ser Ser Gly  Ile Asn Gly 
    1010                 1015                 1020             


Ser Phe  Leu Val Arg Glu Ser  Glu Ser Ser Pro Gly  Gln Arg Ser 
    1025                 1030                 1035             


Ile Ser  Leu Arg Tyr Glu Gly  Arg Val Tyr His Tyr  Arg Ile Asn 
    1040                 1045                 1050             


Thr Ala  Ser Asp Gly Lys Leu  Tyr Val Ser Ser Glu  Ser Arg Phe 
    1055                 1060                 1065             


Asn Thr  Leu Ala Glu Leu Val  His His His Ser Thr  Val Ala Asp 
    1070                 1075                 1080             


Gly Leu  Ile Thr Thr Leu His  Tyr Pro Ala Pro Lys  Arg Asn Lys 
    1085                 1090                 1095             


Pro Thr  Val Tyr Gly Val Ser  Pro Asn Tyr Asp Lys  Trp Glu Met 
    1100                 1105                 1110             


Glu Arg  Thr Asp Ile Thr Met  Lys His Lys Leu Gly  Gly Gly Gln 
    1115                 1120                 1125             


Tyr Gly  Glu Val Tyr Glu Gly  Val Trp Lys Lys Tyr  Ser Leu Thr 
    1130                 1135                 1140             


Val Ala  Val Lys Thr Leu Lys  Glu Asp Thr Met Glu  Val Glu Glu 
    1145                 1150                 1155             


Phe Leu  Lys Glu Ala Ala Val  Met Lys Glu Ile Lys  His Pro Asn 
    1160                 1165                 1170             


Leu Val  Gln Leu Leu Gly Val  Cys Thr Arg Glu Pro  Pro Phe Tyr 
    1175                 1180                 1185             


Ile Ile  Thr Glu Phe Met Thr  Tyr Gly Asn Leu Leu  Asp Tyr Leu 
    1190                 1195                 1200             


Arg Glu  Cys Asn Arg Gln Glu  Val Asn Ala Val Val  Leu Leu Tyr 
    1205                 1210                 1215             


Met Ala  Thr Gln Ile Ser Ser  Ala Met Glu Tyr Leu  Glu Lys Lys 
    1220                 1225                 1230             


Asn Phe  Ile His Arg Asp Leu  Ala Ala Arg Asn Cys  Leu Val Gly 
    1235                 1240                 1245             


Glu Asn  His Leu Val Lys Val  Ala Asp Phe Gly Leu  Ser Arg Leu 
    1250                 1255                 1260             


Met Thr  Gly Asp Thr Tyr Thr  Ala His Ala Gly Ala  Lys Phe Pro 
    1265                 1270                 1275             


Ile Lys  Trp Thr Ala Pro Glu  Ser Leu Ala Tyr Asn  Lys Phe Ser 
    1280                 1285                 1290             


Ile Lys  Ser Asp Val Trp Ala  Phe Gly Val Leu Leu  Trp Glu Ile 
    1295                 1300                 1305             


Ala Thr  Tyr Gly Met Ser Pro  Tyr Pro Gly Ile Asp  Leu Ser Gln 
    1310                 1315                 1320             


Val Tyr  Glu Leu Leu Glu Lys  Asp Tyr Arg Met Glu  Arg Pro Glu 
    1325                 1330                 1335             


Gly Cys  Pro Glu Lys Val Tyr  Glu Leu Met Arg Ala  Cys Trp Gln 
    1340                 1345                 1350             


Trp Asn  Pro Ser Asp Arg Pro  Ser Phe Ala Glu Ile  His Gln Ala 
    1355                 1360                 1365             


Phe Glu  Thr Met Phe Gln Glu  Ser Ser Ile Ser Asp  Glu Val Glu 
    1370                 1375                 1380             


Lys Glu  Leu Gly Lys Gln Gly  Val Arg Gly Ala Val  Ser Thr Leu 
    1385                 1390                 1395             


Leu Gln  Ala Pro Glu Leu Pro  Thr Lys Thr Arg Thr  Ser Arg Arg 
    1400                 1405                 1410             


Ala Ala  Glu His Arg Asp Thr  Thr Asp Val Pro Glu  Met Pro His 
    1415                 1420                 1425             


Ser Lys  Gly Gln Gly Glu Ser  Asp Pro Leu Asp His  Glu Pro Ala 
    1430                 1435                 1440             


Val Ser  Pro Leu Leu Pro Arg  Lys Glu Arg Gly Pro  Pro Glu Gly 
    1445                 1450                 1455             


Gly Leu  Asn Glu Asp Glu Arg  Leu Leu Pro Lys Asp  Lys Lys Thr 
    1460                 1465                 1470             


Asn Leu  Phe Ser Ala Leu Ile  Lys Lys Lys Lys Lys  Thr Ala Pro 
    1475                 1480                 1485             


Thr Pro  Pro Lys Arg Ser Ser  Ser Phe Arg Glu Met  Asp Gly Gln 
    1490                 1495                 1500             


Pro Glu  Arg Arg Gly Ala Gly  Glu Glu Glu Gly Arg  Asp Ile Ser 
    1505                 1510                 1515             


Asn Gly  Ala Leu Ala Phe Thr  Pro Leu Asp Thr Ala  Asp Pro Ala 
    1520                 1525                 1530             


Lys Ser  Pro Lys Pro Ser Asn  Gly Ala Gly Val Pro  Asn Gly Ala 
    1535                 1540                 1545             


Leu Arg  Glu Ser Gly Gly Ser  Gly Phe Arg Ser Pro  His Leu Trp 
    1550                 1555                 1560             


Lys Lys  Ser Ser Thr Leu Thr  Ser Ser Arg Leu Ala  Thr Gly Glu 
    1565                 1570                 1575             


Glu Glu  Gly Gly Gly Ser Ser  Ser Lys Arg Phe Leu  Arg Ser Cys 
    1580                 1585                 1590             


Ser Ala  Ser Cys Val Pro His  Gly Ala Lys Asp Thr  Glu Trp Arg 
    1595                 1600                 1605             


Ser Val  Thr Leu Pro Arg Asp  Leu Gln Ser Thr Gly  Arg Gln Phe 
    1610                 1615                 1620             


Asp Ser  Ser Thr Phe Gly Gly  His Lys Ser Glu Lys  Pro Ala Leu 
    1625                 1630                 1635             


Pro Arg  Lys Arg Ala Gly Glu  Asn Arg Ser Asp Gln  Val Thr Arg 
    1640                 1645                 1650             


Gly Thr  Val Thr Pro Pro Pro  Arg Leu Val Lys Lys  Asn Glu Glu 
    1655                 1660                 1665             


Ala Ala  Asp Glu Val Phe Lys  Asp Ile Met Glu Ser  Ser Pro Gly 
    1670                 1675                 1680             


Ser Ser  Pro Pro Asn Leu Thr  Pro Lys Pro Leu Arg  Arg Gln Val 
    1685                 1690                 1695             


Thr Val  Ala Pro Ala Ser Gly  Leu Pro His Lys Glu  Glu Ala Gly 
    1700                 1705                 1710             


Lys Gly  Ser Ala Leu Gly Thr  Pro Ala Ala Ala Glu  Pro Val Thr 
    1715                 1720                 1725             


Pro Thr  Ser Lys Ala Gly Ser  Gly Ala Pro Gly Gly  Thr Ser Lys 
    1730                 1735                 1740             


Gly Pro  Ala Glu Glu Ser Arg  Val Arg Arg His Lys  His Ser Ser 
    1745                 1750                 1755             


Glu Ser  Pro Gly Arg Asp Lys  Gly Lys Leu Ser Arg  Leu Lys Pro 
    1760                 1765                 1770             


Ala Pro  Pro Pro Pro Pro Ala  Ala Ser Ala Gly Lys  Ala Gly Gly 
    1775                 1780                 1785             


Lys Pro  Ser Gln Ser Pro Ser  Gln Glu Ala Ala Gly  Glu Ala Val 
    1790                 1795                 1800             


Leu Gly  Ala Lys Thr Lys Ala  Thr Ser Leu Val Asp  Ala Val Asn 
    1805                 1810                 1815             


Ser Asp  Ala Ala Lys Pro Ser  Gln Pro Gly Glu Gly  Leu Lys Lys 
    1820                 1825                 1830             


Pro Val  Leu Pro Ala Thr Pro  Lys Pro Gln Ser Ala  Lys Pro Ser 
    1835                 1840                 1845             


Gly Thr  Pro Ile Ser Pro Ala  Pro Val Pro Ser Thr  Leu Pro Ser 
    1850                 1855                 1860             


Ala Ser  Ser Ala Leu Ala Gly  Asp Gln Pro Ser Ser  Thr Ala Phe 
    1865                 1870                 1875             


Ile Pro  Leu Ile Ser Thr Arg  Val Ser Leu Arg Lys  Thr Arg Gln 
    1880                 1885                 1890             


Pro Pro  Glu Arg Ile Ala Ser  Gly Ala Ile Thr Lys  Gly Val Val 
    1895                 1900                 1905             


Leu Asp  Ser Thr Glu Ala Leu  Cys Leu Ala Ile Ser  Arg Asn Ser 
    1910                 1915                 1920             


Glu Gln  Met Ala Ser His Ser  Ala Val Leu Glu Ala  Gly Lys Asn 
    1925                 1930                 1935             


Leu Tyr  Thr Phe Cys Val Ser  Tyr Val Asp Ser Ile  Gln Gln Met 
    1940                 1945                 1950             


Arg Asn  Lys Phe Ala Phe Arg  Glu Ala Ile Asn Lys  Leu Glu Asn 
    1955                 1960                 1965             


Asn Leu  Arg Glu Leu Gln Ile  Cys Pro Ala Thr Ala  Gly Ser Gly 
    1970                 1975                 1980             


Pro Ala  Ala Thr Gln Asp Phe  Ser Lys Leu Leu Ser  Ser Val Lys 
    1985                 1990                 1995             


Glu Ile  Ser Asp Ile Val Gln  Arg 
    2000                 2005     


<210>  14
<211>  8609
<212>  DNA
<213>  Homo sapiens

<400>  14
ggggggaggg tggcggctcg atgggggagc cgcctccagg gggccccccc gccctgtgcc       60

cacggcgcgg cccctttaag aggcccgcct ggctccgtca tccgcgccgc ggccacctcc      120

ccccggccct ccccttcctg cggcgcagag tgcgggccgg gcgggagtgc ggcgagagcc      180

ggctggctga gcttagcgtc cgaggaggcg gcggcggcgg cggcggcacg gcggcggcgg      240

ggctgtgggg cggtgcggaa gcgagaggcg aggagcgcgc gggccgtggc cagagtctgg      300

cggcggcctg gcggagcgga gagcagcgcc cgcgcctcgc cgtgcggagg agccccgcac      360

acaatagcgg cgcgcgcagc ccgcgccctt ccccccggcg cgccccgccc cgcgcgccga      420

gcgccccgct ccgcctcacc tgccaccagg gagtgggcgg gcattgttcg ccgccgccgc      480

cgccgcgcgg gccatggggg ccgcccggcg cccggggccg ggctggcgag gcgccgcgcc      540

gccgctgaga cgggccccgc gcgcagcccg gcggcgcagg taaggccggc cgcgccatgg      600

tggacccggt gggcttcgcg gaggcgtgga aggcgcagtt cccggactca gagcccccgc      660

gcatggagct gcgctcagtg ggcgacatcg agcaggagct ggagcgctgc aaggcctcca      720

ttcggcgcct ggagcaggag gtgaaccagg agcgcttccg catgatctac ctgcagacgt      780

tgctggccaa ggaaaagaag agctatgacc ggcagcgatg gggcttccgg cgcgcggcgc      840

aggcccccga cggcgcctcc gagccccgag cgtccgcgtc gcgcccgcag ccagcgcccg      900

ccgacggagc cgacccgccg cccgccgagg agcccgaggc ccggcccgac ggcgagggtt      960

ctccgggtaa ggccaggccc gggaccgccc gcaggcccgg ggcagccgcg tcgggggaac     1020

gggacgaccg gggacccccc gccagcgtgg cggcgctcag gtccaacttc gagcggatcc     1080

gcaagggcca tggccagccc ggggcggacg ccgagaagcc cttctacgtg aacgtcgagt     1140

ttcaccacga gcgcggcctg gtgaaggtca acgacaaaga ggtgtcggac cgcatcagct     1200

ccctgggcag ccaggccatg cagatggagc gcaaaaagtc ccagcacggc gcgggctcga     1260

gcgtggggga tgcatccagg cccccttacc ggggacgctc ctcggagagc agctgcggcg     1320

tcgacggcga ctacgaggac gccgagttga acccccgctt cctgaaggac aacctgatcg     1380

acgccaatgg cggtagcagg cccccttggc cgcccctgga gtaccagccc taccagagca     1440

tctacgtcgg gggcatgatg gaaggggagg gcaagggccc gctcctgcgc agccagagca     1500

cctctgagca ggagaagcgc cttacctggc cccgcaggtc ctactccccc cggagttttg     1560

aggattgcgg aggcggctat accccggact gcagctccaa tgagaacctc acctccagcg     1620

aggaggactt ctcctctggc cagtccagcc gcgtgtcccc aagccccacc acctaccgca     1680

tgttccggga caaaagccgc tctccctcgc agaactcgca acagtccttc gacagcagca     1740

gtccccccac gccgcagtgc cataagcggc accggcactg cccggttgtc gtgtccgagg     1800

ccaccatcgt gggcgtccgc aagaccgggc agatctggcc caacgatggc gagggcgcct     1860

tccatggaga cgcagatggc tcgttcggaa caccacctgg atacggctgc gctgcagacc     1920

gggcagagga gcagcgccgg caccaagatg ggctgcccta cattgatgac tcgccctcct     1980

catcgcccca cctcagcagc aagggcaggg gcagccggga tgcgctggtc tcgggagccc     2040

tggagtccac taaagcgagt gagctggact tggaaaaggg cttggagatg agaaaatggg     2100

tcctgtcggg aatcctggct agcgaggaga cttacctgag ccacctggag gcactgctgc     2160

tgcccatgaa gcctttgaaa gccgctgcca ccacctctca gccggtgctg acgagtcagc     2220

agatcgagac catcttcttc aaagtgcctg agctctacga gatccacaag gagttctatg     2280

atgggctctt cccccgcgtg cagcagtgga gccaccagca gcgggtgggc gacctcttcc     2340

agaagctggc cagccagctg ggtgtgtacc gggccttcgt ggacaactac ggagttgcca     2400

tggaaatggc tgagaagtgc tgtcaggcca atgctcagtt tgcagaaatc tccgagaacc     2460

tgagagccag aagcaacaaa gatgccaagg atccaacgac caagaactct ctggaaactc     2520

tgctctacaa gcctgtggac cgtgtgacga ggagcacgct ggtcctccat gacttgctga     2580

agcacactcc tgccagccac cctgaccacc ccttgctgca ggacgccctc cgcatctcac     2640

agaacttcct gtccagcatc aatgaggaga tcacaccccg acggcagtcc atgacggtga     2700

agaagggaga gcaccggcag ctgctgaagg acagcttcat ggtggagctg gtggaggggg     2760

cccgcaagct gcgccacgtc ttcctgttca ccgacctgct tctctgcacc aagctcaaga     2820

agcagagcgg aggcaaaacg cagcagtatg actgcaaatg gtacattccg ctcacggatc     2880

tcagcttcca gatggtggat gaactggagg cagtgcccaa catccccctg gtgcccgatg     2940

aggagctgga cgctttgaag atcaagatct cccagatcaa gaatgacatc cagagagaga     3000

agagggcgaa caagggcagc aaggctacgg agaggctgaa gaagaagctg tcggagcagg     3060

agtcactgct gctgcttatg tctcccagca tggccttcag ggtgcacagc cgcaacggca     3120

agagttacac gttcctgatc tcctctgact atgagcgtgc agagtggagg gagaacatcc     3180

gggagcagca gaagaagtgt ttcagaagct tctccctgac atccgtggag ctgcagatgc     3240

tgaccaactc gtgtgtgaaa ctccagactg tccacagcat tccgctgacc atcaataagg     3300

aagaagccct tcagcggcca gtagcatctg actttgagcc tcagggtctg agtgaagccg     3360

ctcgttggaa ctccaaggaa aaccttctcg ctggacccag tgaaaatgac cccaaccttt     3420

tcgttgcact gtatgatttt gtggccagtg gagataacac tctaagcata actaaaggtg     3480

aaaagctccg ggtcttaggc tataatcaca atggggaatg gtgtgaagcc caaaccaaaa     3540

atggccaagg ctgggtccca agcaactaca tcacgccagt caacagtctg gagaaacact     3600

cctggtacca tgggcctgtg tcccgcaatg ccgctgagta tctgctgagc agcgggatca     3660

atggcagctt cttggtgcgt gagagtgaga gcagtcctgg ccagaggtcc atctcgctga     3720

gatacgaagg gagggtgtac cattacagga tcaacactgc ttctgatggc aagctctacg     3780

tctcctccga gagccgcttc aacaccctgg ccgagttggt tcatcatcat tcaacggtgg     3840

ccgacgggct catcaccacg ctccattatc cagccccaaa gcgcaacaag cccactgtct     3900

atggtgtgtc ccccaactac gacaagtggg agatggaacg cacggacatc accatgaagc     3960

acaagctggg cgggggccag tacggggagg tgtacgaggg cgtgtggaag aaatacagcc     4020

tgacggtggc cgtgaagacc ttgaaggagg acaccatgga ggtggaagag ttcttgaaag     4080

aagctgcagt catgaaagag atcaaacacc ctaacctggt gcagctcctt ggggtctgca     4140

cccgggagcc cccgttctat atcatcactg agttcatgac ctacgggaac ctcctggact     4200

acctgaggga gtgcaaccgg caggaggtga acgccgtggt gctgctgtac atggccactc     4260

agatctcgtc agccatggag tacctggaga agaaaaactt catccacaga gatcttgctg     4320

cccgaaactg cctggtaggg gagaaccact tggtgaaggt agctgatttt ggcctgagca     4380

ggttgatgac aggggacacc tacacagccc atgctggagc caagttcccc atcaaatgga     4440

ctgcacccga gagcctggcc tacaacaagt tctccatcaa gtccgacgtc tgggcatttg     4500

gagtattgct ttgggaaatt gctacctatg gcatgtcccc ttacccggga attgacctgt     4560

cccaggtgta tgagctgcta gagaaggact accgcatgga gcgcccagaa ggctgcccag     4620

agaaggtcta tgaactcatg cgagcatgtt ggcagtggaa tccctctgac cggccctcct     4680

ttgctgaaat ccaccaagcc tttgaaacaa tgttccagga atccagtatc tcagacgaag     4740

tggaaaagga gctggggaaa caaggcgtcc gtggggctgt gagtaccttg ctgcaggccc     4800

cagagctgcc caccaagacg aggacctcca ggagagctgc agagcacaga gacaccactg     4860

acgtgcctga gatgcctcac tccaagggcc agggagagag cgatcctctg gaccatgagc     4920

ctgccgtgtc tccattgctc cctcgaaaag agcgaggtcc cccggagggc ggcctgaatg     4980

aagatgagcg ccttctcccc aaagacaaaa agaccaactt gttcagcgcc ttgatcaaga     5040

agaagaagaa gacagcccca acccctccca aacgcagcag ctccttccgg gagatggacg     5100

gccagccgga gcgcagaggg gccggcgagg aagagggccg agacatcagc aacggggcac     5160

tggctttcac ccccttggac acagctgacc cagccaagtc cccaaagccc agcaatgggg     5220

ctggggtccc caatggagcc ctccgggagt ccgggggctc aggcttccgg tctccccacc     5280

tgtggaagaa gtccagcacg ctgaccagca gccgcctagc caccggcgag gaggagggcg     5340

gtggcagctc cagcaagcgc ttcctgcgct cttgctccgc ctcctgcgtt ccccatgggg     5400

ccaaggacac ggagtggagg tcagtcacgc tgcctcggga cttgcagtcc acgggaagac     5460

agtttgactc gtccacattt ggagggcaca aaagtgagaa gccggctctg cctcggaaga     5520

gggcagggga gaacaggtct gaccaggtga cccgaggcac agtaacgcct ccccccaggc     5580

tggtgaaaaa gaatgaggaa gctgctgatg aggtcttcaa agacatcatg gagtccagcc     5640

cgggctccag cccgcccaac ctgactccaa aacccctccg gcggcaggtc accgtggccc     5700

ctgcctcggg cctcccccac aaggaagaag ctggaaaggg cagtgcctta gggacccctg     5760

ctgcagctga gccagtgacc cccaccagca aagcaggctc aggtgcacca gggggcacca     5820

gcaagggccc cgccgaggag tccagagtga ggaggcacaa gcactcctct gagtcgccag     5880

ggagggacaa ggggaaattg tccaggctca aacctgcccc gccgccccca ccagcagcct     5940

ctgcagggaa ggctggagga aagccctcgc agagcccgag ccaggaggcg gccggggagg     6000

cagtcctggg cgcaaagaca aaagccacga gtctggttga tgctgtgaac agtgacgctg     6060

ccaagcccag ccagccggga gagggcctca aaaagcccgt gctcccggcc actccaaagc     6120

cacagtccgc caagccgtcg gggaccccca tcagcccagc ccccgttccc tccacgttgc     6180

catcagcatc ctcggccctg gcaggggacc agccgtcttc caccgccttc atccctctca     6240

tatcaacccg agtgtctctt cggaaaaccc gccagcctcc agagcggatc gccagcggcg     6300

ccatcaccaa gggcgtggtc ctggacagca ccgaggcgct gtgcctcgcc atctctagga     6360

actccgagca gatggccagc cacagcgcag tgctggaggc cggcaaaaac ctctacacgt     6420

tctgcgtgag ctatgtggat tccatccagc aaatgaggaa caagtttgcc ttccgagagg     6480

ccatcaacaa actggagaat aatctccggg agcttcagat ctgcccggcg acagcaggca     6540

gtggtccagc ggccactcag gacttcagca agctcctcag ttcggtgaag gaaatcagtg     6600

acatagtgca gaggtagcag cagtcagggg tcaggtgtca ggcccgtcgg agctgcctgc     6660

agcacatgcg ggctcgccca tacccgtgac agtggctgac aagggactag tgagtcagca     6720

ccttggccca ggagctctgc gccaggcaga gctgagggcc ctgtggagtc cagctctact     6780

acctacgttt gcaccgcctg ccctcccgca ccttcctcct ccccgctccg tctctgtcct     6840

cgaattttat ctgtggagtt cctgctccgt ggactgcagt cggcatgcca ggacccgcca     6900

gccccgctcc cacctagtgc cccagactga gctctccagg ccaggtggga acggctgatg     6960

tggactgtct ttttcatttt tttctctctg gagcccctcc tcccccggct gggcctcctt     7020

cttccacttc tccaagaatg gaagcctgaa ctgaggcctt gtgtgtcagg ccctctgcct     7080

gcactccctg gccttgcccg tcgtgtgctg aagacatgtt tcaagaaccg catttcggga     7140

agggcatgca cgggcatgca cacggctggt cactctgccc tctgctgctg cccggggtgg     7200

ggtgcactcg ccatttcctc acgtgcagga cagctcttga tttgggtgga aaacagggtg     7260

ctaaagccaa ccagcctttg ggtcctgggc aggtgggagc tgaaaaggat cgaggcatgg     7320

ggcatgtcct ttccatctgt ccacatcccc agagcccagc tcttgctctc ttgtgacgtg     7380

cactgtgaat cctggcaaga aagcttgagt ctcaagggtg gcaggtcact gtcactgccg     7440

acatccctcc cccagcagaa tggaggcagg ggacaaggga ggcagtggct agtggggtga     7500

acagctggtg ccaaatagcc ccagactggg cccaggcagg tctgcaaggg cccagagtga     7560

accgtccttt cacacatctg ggtgccctga aagggccctt cccctccccc actcctctaa     7620

gacaaagtag attcttacaa ggccctttcc tttggaacaa gacagccttc acttttctga     7680

gttcttgaag catttcaaag ccctgcctct gtgtagccgc cctgagagag aatagagctg     7740

ccactgggca cctgcgcaca ggtgggagga aagggcctgg ccagtcctgg tcctggctgc     7800

actcttgaac tgggcgaatg tcttatttaa ttaccgtgag tgacatagcc tcatgttctg     7860

tgggggtcat cagggagggt taggaaaacc acaaacggag cccctgaaag cctcacgtat     7920

ttcacagagc acgcctgcca tcttctcccc gaggctgccc caggccggag cccagatacg     7980

ggggctgtga ctctgggcag ggacccgggg tctcctggac cttgacagag cagctaactc     8040

cgagagcagt gggcaggtgg ccgcccctga ggcttcacgc cgggagaagc caccttccca     8100

ccccttcata ccgcctcgtg ccagcagcct cgcacaggcc ctagctttac gctcatcacc     8160

taaacttgta ctttattttt ctgatagaaa tggtttcctc tggatcgttt tatgcggttc     8220

ttacagcaca tcacctcttt gcccccgacg gctgtgacgc agccggaggg aggcactagt     8280

caccgacagc ggccttgaag acagagcaaa gcgcccaccc aggtcccccg actgcctgtc     8340

tccatgaggt actggtccct tccttttgtt aacgtgatgt gccactatat tttacacgta     8400

tctcttggta tgcatctttt atagacgctc ttttctaagt ggcgtgtgca tagcgtcctg     8460

ccctgccccc tcgggggcct gtggtggctc cccctctgct tctcggggtc cagtgcattt     8520

tgtttctgta tatgattctc tgtggttttt tttgaatcca aatctgtcct ctgtagtatt     8580

ttttaaataa atcagtgttt acattagaa                                       8609


