                         SEQUENCE LISTING

<110>  The UAB Research Foundation
       Kutsch, Olaf
       Wolschendorf, Frank
 
<120>  Latent Human Immunodeficiency Virus Reactivation

<130>  10030-152WO1

<150>  61/559,999
<151>  2011-11-15

<160>  14    

<170>  PatentIn version 3.5

<210>  1
<211>  1398
<212>  DNA
<213>  Massilia timonae


<220>
<221>  misc_feature
<222>  (971)..(971)
<223>  n is a or t

<400>  1
tgaacgctgg cggcatgctt tacacatgca agtcgaacgg taacagggag cttgctccgc       60

tgacgagtgg cgaacgggtg agtaatatat cggaacgtac ccaagagtgg gggataacgt      120

agcgaaagtt acgctaatac cgcatacgat ctatggatga aagcagggga ccttcgggcc      180

ttgtgctcct ggagcggccg atatctgatt agctagttgg tgaggtaaag gctcaccaag      240

gcgacgatca gtagctggtc tgagaggacg accagccaca ctggaactga gacacggtcc      300

agactcctac gggaggcagc agtggggaat tttggacaat gggcgcaagc ctgatccagc      360

aatgccgcgt gagtgaagaa ggccttcggg ttgtaaagct cttttgtcag ggaagaaacg      420

gctgtggcta atatccacgg ctaatgacgg tacctgaaga ataagcaccg gctaactacg      480

tgccagcagc cgcggtaata cgtagggtgc aagcgttaat cggaattact gggcgtaaag      540

cgtgcgcagg cggttttgta agtctgtcgt gaaatccccg ggctcaacct gggaattgcg      600

atggagactg caaggctaga atctggcaga ggggggtaga attccacgtg tagcagtgaa      660

atgcgtagag atgtggagga acaccgatgg cgaaggcagc cccctgggtc aagattgacg      720

ctcatgcacg aaagcgtggg gagcaaacag gattagatac cctggtagtc cacgccctaa      780

acgatgtcta ctagttgtcg ggttttaatt aacttggtaa cgcagctaac gcgtgaagta      840

gaccgcctgg ggagtacggt cgcaagatta aaactcaaag gaattgacgg ggacccgcac      900

aagcggtgga tgatgtggat taattcgatg caacgcgaaa aaccttacct acccttgaca      960

tgtcaggaag nccgaagaga tttggttgtg cccgaaaggg aacctgaaca caggtgctgc     1020

atggctgtcg tcagctcgtg tcgtgagatg ttgggttaag tcccgcaacg agcgcaaccc     1080

ttgtcattag ttgctacgca agagcactct aatgagactg ccggtgacaa accggaggaa     1140

ggtggggatg acgtcaagtc ctcatggccc ttatgggtag ggcttcacac gtcatacaat     1200

ggtacataca gagggccgcc aacccgcgag ggggagctaa tcccagaaag tgtatcgtag     1260

tccggatcgt agtctgcaac tcgactacgt gaagttggaa tcgctagtaa tcgcggatca     1320

gcatgccgcg gtgaatacgt tcccgggtct tgtacacacc gcccgtcaca ccatgggagc     1380

gggttttacc agaagtag                                                   1398


<210>  2
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2
ggcgcggaga tcttaacgaa gacagggcca tgt                                    33


<210>  3
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  3
gccaataccg gtgtgtcctt tccaggggag ag                                     32


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  4
agagtttgat cctggctcag                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  5
acggctacct tgttacgact t                                                 21


<210>  6
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  6
ccctaaacga tgtctactag ttgt                                              24


<210>  7
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  7
ttcgggcaca accaaatctc ttcg                                              24


<210>  8
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  8
ggctcaacct cccaattgcg atg                                               23


<210>  9
<211>  1458
<212>  DNA
<213>  Massilia timonae

<400>  9
atggcatccg taatcaatac caacgttcct tccctgaatt cgcagcgtaa cctgtcgacc       60

tcgcaagcac agctgaacac ctcgattcag cgtctgtcgt cgggcatgcg catcaacagc      120

gcgaaggacg acgccgccgg cctcgcgatt tccgatcgca tgaattcgca gatcaagggc      180

atgacccagg ctacccgtaa cgccaacgat ggcgtgtcga tggcccagac cgccgaaggc      240

gctctgtcga gctcgggcga catcctgcag cgtatccgcg aactggcagt gcagtcgtcg      300

aactcgtcga actcggccag cgaccgcaag gccctgcaga ccgaagttac ccaactgagc      360

tcggaactga atcgcatcgc caacaccacc gagttcaacg gccagaagct gatggacggc      420

accctgggta ccgcgaattt ccaggtcggc gccaatgcgg ggcagctgat ctcgatgacc      480

ggcgcgaact tcaacacctc ggtgtacggc aacaaccaga tcgctggcga tgccgcgaag      540

gcagcagcca cgacgtcggc ggccgccact ggagcattta ccatttcagg ctacctcggc      600

acgagcgccg cgattaacac gaccgatgct gacacggcaa agaccatcgc cgcgagcatc      660

aacaacgtca ccggcgatac tggtgtcacc gcaaccgccc gtaccgattc gttcctcaag      720

agcgcaggcg gtgcgcatac catgagcctg gcctcggaca actcgggtac cggcgaagct      780

gtcgacatct cgttcactgt cggtgacggc ggcgatacgg ccgacgacta cgcggcagcc      840

atcagcgcct tcaacgcaca aaccgcgaag actggcgtga ccgccgagta tgatgcagtc      900

gaaaaaggtc tcaagctgac caactcggcc ggtgaaaaca tttcgctgac caacaaagcc      960

ggtagcgccg atatcgacat ggacacctac gccgccgacg gcgcgctgat ggcctccgca     1020

ctcaccctgg aggctggcga cgttggcgtg gccaacggtc gcgtgaccat ggactccgag     1080

aagagcttct cggtggccga aggcaccgat acgggttttg aactcgcgga ttcgtcagcc     1140

ttgaaatcgg tcgccaagat cgacatcagc gacttcgagg gcgcacagga agccatcaag     1200

gtcgccgatg ccgccctctc ggccgtcaac agccagcgcg ctgaatacgg cgcactgcag     1260

tcgcgcttcg aatcggcgat ctcgaacctg tcgtcgtcga ccgagaacct gtcggcatcg     1320

cgcagccgca tcgtcgatac cgacttcgca gctgaaaccg caaagatgac ccgcggccag     1380

atcctgcagc aagctggtac ctcgatgctg gctcaggcta actccctgcc gaacggtgtc     1440

ctgtcgctgc tgcgtggc                                                   1458


<210>  10
<211>  486
<212>  PRT
<213>  Massilia timonae

<400>  10

Met Ala Ser Val Ile Asn Thr Asn Val Pro Ser Leu Asn Ser Gln Arg 
1               5                   10                  15      


Asn Leu Ser Thr Ser Gln Ala Gln Leu Asn Thr Ser Ile Gln Arg Leu 
            20                  25                  30          


Ser Ser Gly Met Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Leu 
        35                  40                  45              


Ala Ile Ser Asp Arg Met Asn Ser Gln Ile Lys Gly Met Thr Gln Ala 
    50                  55                  60                  


Thr Arg Asn Ala Asn Asp Gly Val Ser Met Ala Gln Thr Ala Glu Gly 
65                  70                  75                  80  


Ala Leu Ser Ser Ser Gly Asp Ile Leu Gln Arg Ile Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ser Asn Ser Ser Asn Ser Ala Ser Asp Arg Lys Ala Leu 
            100                 105                 110         


Gln Thr Glu Val Thr Gln Leu Ser Ser Glu Leu Asn Arg Ile Ala Asn 
        115                 120                 125             


Thr Thr Glu Phe Asn Gly Gln Lys Leu Met Asp Gly Thr Leu Gly Thr 
    130                 135                 140                 


Ala Asn Phe Gln Val Gly Ala Asn Ala Gly Gln Leu Ile Ser Met Thr 
145                 150                 155                 160 


Gly Ala Asn Phe Asn Thr Ser Val Tyr Gly Asn Asn Gln Ile Ala Gly 
                165                 170                 175     


Asp Ala Ala Lys Ala Ala Ala Thr Thr Ser Ala Ala Ala Thr Gly Ala 
            180                 185                 190         


Phe Thr Ile Ser Gly Tyr Leu Gly Thr Ser Ala Ala Ile Asn Thr Thr 
        195                 200                 205             


Asp Ala Asp Thr Ala Lys Thr Ile Ala Ala Ser Ile Asn Asn Val Thr 
    210                 215                 220                 


Gly Asp Thr Gly Val Thr Ala Thr Ala Arg Thr Asp Ser Phe Leu Lys 
225                 230                 235                 240 


Ser Ala Gly Gly Ala His Thr Met Ser Leu Ala Ser Asp Asn Ser Gly 
                245                 250                 255     


Thr Gly Glu Ala Val Asp Ile Ser Phe Thr Val Gly Asp Gly Gly Asp 
            260                 265                 270         


Thr Ala Asp Asp Tyr Ala Ala Ala Ile Ser Ala Phe Asn Ala Gln Thr 
        275                 280                 285             


Ala Lys Thr Gly Val Thr Ala Glu Tyr Asp Ala Val Glu Lys Gly Leu 
    290                 295                 300                 


Lys Leu Thr Asn Ser Ala Gly Glu Asn Ile Ser Leu Thr Asn Lys Ala 
305                 310                 315                 320 


Gly Ser Ala Asp Ile Asp Met Asp Thr Tyr Ala Ala Asp Gly Ala Leu 
                325                 330                 335     


Met Ala Ser Ala Leu Thr Leu Glu Ala Gly Asp Val Gly Val Ala Asn 
            340                 345                 350         


Gly Arg Val Thr Met Asp Ser Glu Lys Ser Phe Ser Val Ala Glu Gly 
        355                 360                 365             


Thr Asp Thr Gly Phe Glu Leu Ala Asp Ser Ser Ala Leu Lys Ser Val 
    370                 375                 380                 


Ala Lys Ile Asp Ile Ser Asp Phe Glu Gly Ala Gln Glu Ala Ile Lys 
385                 390                 395                 400 


Val Ala Asp Ala Ala Leu Ser Ala Val Asn Ser Gln Arg Ala Glu Tyr 
                405                 410                 415     


Gly Ala Leu Gln Ser Arg Phe Glu Ser Ala Ile Ser Asn Leu Ser Ser 
            420                 425                 430         


Ser Thr Glu Asn Leu Ser Ala Ser Arg Ser Arg Ile Val Asp Thr Asp 
        435                 440                 445             


Phe Ala Ala Glu Thr Ala Lys Met Thr Arg Gly Gln Ile Leu Gln Gln 
    450                 455                 460                 


Ala Gly Thr Ser Met Leu Ala Gln Ala Asn Ser Leu Pro Asn Gly Val 
465                 470                 475                 480 


Leu Ser Leu Leu Arg Gly 
                485     


<210>  11
<211>  495
<212>  PRT
<213>  Salmonella typhimurium

<400>  11

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Leu Thr Gln Asn 
1               5                   10                  15      


Asn Leu Asn Lys Ser Gln Ser Ala Leu Gly Thr Ala Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ala Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ser Arg Asn Ala Asn Asp Gly Ile Ser Ile Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Asn Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Ala 
                85                  90                  95      


Val Gln Ser Ala Asn Ser Thr Asn Ser Gln Ser Asp Leu Asp Ser Ile 
            100                 105                 110         


Gln Ala Glu Ile Thr Gln Arg Leu Asn Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Lys Val Leu Ala Gln Asp Asn Thr Leu 
    130                 135                 140                 


Thr Ile Gln Val Gly Ala Asn Asp Gly Glu Thr Ile Asp Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asn Ser Gln Thr Leu Gly Leu Asp Thr Leu Asn Val Gln 
                165                 170                 175     


Gln Lys Tyr Lys Val Ser Asp Thr Ala Ala Thr Val Thr Gly Tyr Ala 
            180                 185                 190         


Asp Thr Thr Ile Ala Leu Asp Asn Ser Thr Phe Lys Ala Ser Ala Thr 
        195                 200                 205             


Gly Leu Gly Gly Thr Asp Gln Lys Ile Asp Gly Asp Leu Lys Phe Asp 
    210                 215                 220                 


Asp Thr Thr Gly Lys Tyr Tyr Ala Lys Val Thr Val Thr Gly Gly Thr 
225                 230                 235                 240 


Gly Lys Asp Gly Tyr Tyr Glu Val Ser Val Asp Lys Thr Asn Gly Glu 
                245                 250                 255     


Val Thr Leu Ala Gly Gly Ala Thr Ser Pro Leu Thr Gly Gly Leu Pro 
            260                 265                 270         


Ala Thr Ala Thr Glu Asp Val Lys Asn Val Gln Val Ala Asn Ala Asp 
        275                 280                 285             


Leu Thr Glu Ala Lys Ala Ala Leu Thr Ala Ala Gly Val Thr Gly Thr 
    290                 295                 300                 


Ala Ser Val Val Lys Met Ser Tyr Thr Asp Asn Asn Gly Lys Thr Ile 
305                 310                 315                 320 


Asp Gly Gly Leu Ala Val Lys Val Gly Asp Asp Tyr Tyr Ser Ala Thr 
                325                 330                 335     


Gln Asn Lys Asp Gly Ser Ile Ser Ile Asn Thr Thr Lys Tyr Thr Ala 
            340                 345                 350         


Asp Asp Gly Thr Ser Lys Thr Ala Leu Asn Lys Leu Gly Gly Ala Asp 
        355                 360                 365             


Gly Lys Thr Glu Val Val Ser Ile Gly Gly Lys Thr Tyr Ala Ala Ser 
    370                 375                 380                 


Lys Ala Glu Gly His Asn Phe Lys Ala Gln Pro Asp Leu Ala Glu Ala 
385                 390                 395                 400 


Ala Ala Thr Thr Thr Glu Asn Pro Leu Gln Lys Ile Asp Ala Ala Leu 
                405                 410                 415     


Ala Gln Val Asp Thr Leu Arg Ser Asp Leu Gly Ala Val Gln Asn Arg 
            420                 425                 430         


Phe Asn Ser Ala Ile Thr Asn Leu Gly Asn Thr Val Asn Asn Leu Thr 
        435                 440                 445             


Ser Ala Arg Ser Arg Ile Glu Asp Ser Asp Tyr Ala Thr Glu Val Ser 
    450                 455                 460                 


Asn Met Ser Arg Ala Gln Ile Leu Gln Gln Ala Gly Thr Ser Val Leu 
465                 470                 475                 480 


Ala Gln Ala Asn Gln Val Pro Gln Asn Val Leu Ser Leu Leu Arg 
                485                 490                 495 


<210>  12
<211>  498
<212>  PRT
<213>  Escherichia coli

<400>  12

Met Ala Gln Val Ile Asn Thr Asn Ser Leu Ser Leu Ile Thr Gln Asn 
1               5                   10                  15      


Asn Ile Asn Lys Asn Gln Ser Ala Leu Ser Ser Ser Ile Glu Arg Leu 
            20                  25                  30          


Ser Ser Gly Leu Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Gln 
        35                  40                  45              


Ala Ile Ala Asn Arg Phe Thr Ser Asn Ile Lys Gly Leu Thr Gln Ala 
    50                  55                  60                  


Ala Arg Asn Ala Asn Asp Gly Ile Ser Val Ala Gln Thr Thr Glu Gly 
65                  70                  75                  80  


Ala Leu Ser Glu Ile Asn Asn Asn Leu Gln Arg Val Arg Glu Leu Thr 
                85                  90                  95      


Val Gln Ala Thr Thr Gly Thr Asn Ser Glu Ser Asp Leu Ser Ser Ile 
            100                 105                 110         


Gln Asp Glu Ile Lys Ser Arg Leu Asp Glu Ile Asp Arg Val Ser Gly 
        115                 120                 125             


Gln Thr Gln Phe Asn Gly Val Asn Val Leu Ala Lys Asn Gly Ser Met 
    130                 135                 140                 


Lys Ile Gln Val Gly Ala Asn Asp Asn Gln Thr Ile Thr Ile Asp Leu 
145                 150                 155                 160 


Lys Gln Ile Asp Ala Lys Thr Leu Gly Leu Asp Gly Phe Ser Val Lys 
                165                 170                 175     


Asn Asn Asp Thr Val Thr Thr Ser Ala Pro Val Thr Ala Phe Gly Ala 
            180                 185                 190         


Thr Thr Thr Asn Asn Ile Lys Leu Thr Gly Ile Thr Leu Ser Thr Glu 
        195                 200                 205             


Ala Ala Thr Asp Thr Gly Gly Thr Asn Pro Ala Ser Ile Glu Gly Val 
    210                 215                 220                 


Tyr Thr Asp Asn Gly Asn Asp Tyr Tyr Ala Lys Ile Thr Gly Gly Asp 
225                 230                 235                 240 


Asn Asp Gly Lys Tyr Tyr Ala Val Thr Val Ala Asn Asp Gly Thr Val 
                245                 250                 255     


Thr Met Ala Thr Gly Ala Thr Ala Asn Ala Thr Val Thr Asp Ala Asn 
            260                 265                 270         


Thr Thr Lys Ala Thr Thr Ile Thr Ser Gly Gly Thr Pro Val Gln Ile 
        275                 280                 285             


Asp Asn Thr Ala Gly Ser Ala Thr Ala Asn Leu Gly Ala Val Ser Leu 
    290                 295                 300                 


Val Lys Leu Gln Asp Ser Lys Gly Asn Asp Thr Asp Thr Tyr Ala Leu 
305                 310                 315                 320 


Lys Asp Thr Asn Gly Asn Leu Tyr Ala Ala Asp Val Asn Glu Thr Thr 
                325                 330                 335     


Gly Ala Val Ser Val Lys Thr Ile Thr Tyr Thr Asp Ser Ser Gly Ala 
            340                 345                 350         


Ala Ser Ser Pro Thr Ala Val Lys Leu Gly Gly Asp Asp Gly Lys Thr 
        355                 360                 365             


Glu Val Val Asp Ile Asp Gly Lys Thr Tyr Asp Ser Ala Asp Leu Asn 
    370                 375                 380                 


Gly Gly Asn Leu Gln Thr Gly Leu Thr Ala Gly Gly Glu Ala Leu Thr 
385                 390                 395                 400 


Ala Val Ala Asn Gly Lys Thr Thr Asp Pro Leu Lys Ala Leu Asp Asp 
                405                 410                 415     


Ala Ile Ala Ser Val Asp Lys Phe Arg Ser Ser Leu Gly Ala Val Gln 
            420                 425                 430         


Asn Arg Leu Asp Ser Ala Val Thr Asn Leu Asn Asn Thr Thr Thr Asn 
        435                 440                 445             


Leu Ser Glu Ala Gln Ser Arg Ile Gln Asp Ala Asp Tyr Ala Thr Glu 
    450                 455                 460                 


Val Ser Asn Met Ser Lys Ala Gln Ile Ile Gln Gln Ala Gly Asn Ser 
465                 470                 475                 480 


Val Leu Ala Lys Ala Asn Gln Val Pro Gln Gln Val Leu Ser Leu Leu 
                485                 490                 495     


Gln Gly 
        


<210>  13
<211>  102
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  13

Met Ala Val Ile Asn Thr Asn Ser Leu Gln Asn Leu Ser Gln Leu Thr 
1               5                   10                  15      


Ile Arg Leu Ser Ser Gly Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala 
            20                  25                  30          


Gly Ala Ile Arg Ile Lys Gly Thr Gln Ala Arg Asn Ala Asn Asp Gly 
        35                  40                  45              


Ser Ala Gln Thr Glu Gly Ala Leu Leu Gln Arg Arg Glu Leu Ala Val 
    50                  55                  60                  


Gln Ser Asn Ser Asn Ser Ser Asp Gln Glu Thr Gln Glu Arg Thr Phe 
65                  70                  75                  80  


Asn Gly Lys Asp Thr Leu Gln Val Gly Ala Asn Gly Ile Asn Gly Thr 
                85                  90                  95      


Ala Thr Gly Tyr Thr Ala 
            100         


<210>  14
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  14

Met Ala Val Ile Asn Thr Asn Ser Leu Gln Asn Gln Leu Ser Ile Arg 
1               5                   10                  15      


Leu Ser Ser Gly Arg Ile Asn Ser Ala Lys Asp Asp Ala Ala Gly Ala 
            20                  25                  30          


Ile Arg Ser Ile Lys Gly Thr Gln Ala Arg Asn Ala Asn Asp Gly Ser 
        35                  40                  45              


Ala Gln Thr Glu Gly Ala Leu Ser Leu Gln Arg Arg Glu Leu Val Gln 
    50                  55                  60                  


Asn Ser Ser Asp Gln Glu Glu Arg Thr Phe Asn Gly Gly Gln Val Gly 
65                  70                  75                  80  


Ala Asn Gln Ile Gly Gly Lys Thr Thr Ser Ala Thr Gly Ala Thr Thr 
                85                  90                  95      


Thr Ala Asp Thr Thr Ala Ser Ile Val Asp Gly Asp Lys Gly Gly Asp 
            100                 105                 110         


Asn Gly Ala Val Asp Gly Gly Thr Ala Ala Thr Gly Thr Asn Ala Gly 
        115                 120                 125             


Ser Leu Ser Asp Asp Thr Tyr Ala Leu Leu Ala Asp Val Gly Val Ser 
    130                 135                 140                 


Ala Thr Leu Val Ile Asp Ala Lys Asp Ala Val Arg Gly Ala Gln Arg 
145                 150                 155                 160 


Ser Ala Asn Leu Thr Asn Leu Ser Ser Arg Ile Asp Asp Ala Glu Met 
                165                 170                 175     


Gln Ile Gln Gln Ala Gly Ser Leu Ala Ala Asn Pro Val Leu Ser Leu 
            180                 185                 190         


Leu Gly 
        


