
                                SEQUENCE LISTING

<110> Burden, Steven J.

<120> Muscle Specific Receptor Kinase and Modulation Thereof

<130> 1049-1-175PCT

<150> 61/559,309          
<151> 2011-11-14  

<150> 61/693,857          
<151> 2012-08-28  

<160> 10

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 7343
<212> DNA
<213> Homo sapiens

<400> 1
cccgtccccg gcgcggcccg cgcgctcctc cgccgcctct cgcctgcgcc atggccggcc 60
ggtcccaccc gggcccgctg cggccgctgc tgccgctcct tgtggtggcc gcgtgcgtcc 120
tgcccggagc cggcgggaca tgcccggagc gcgcgctgga gcggcgcgag gaggaggcga 180
acgtggtgct caccgggacg gtggaggaga tcctcaacgt ggacccggtg cagcacacgt 240
actcctgcaa ggttcgggtc tggcggtact tgaagggcaa agacctggtg gcccgggaga 300
gcctgctgga cggcggcaac aaggtggtga tcagcggctt tggagacccc ctcatctgtg 360
acaaccaggt gtccactggg gacaccagga tcttctttgt gaaccctgca cccccatacc 420
tgtggccagc ccacaagaac gagctgatgc tcaactccag cctcatgcgg atcaccctgc 480
ggaacctgga ggaggtggag ttctgtgtgg aagataaacc cgggacccac ttcactccag 540
tgcctccgac gcctcctgat gcgtgccggg gaatgctgtg cggcttcggc gccgtgtgcg 600
agcccaacgc ggaggggccg ggccgggcgt cctgcgtctg caagaagagc ccgtgcccca 660
gcgtggtggc gcctgtgtgt gggtcggacg cctccaccta cagcaacgaa tgcgagctgc 720
agcgggcgca gtgcagccag cagcgccgca tccgcctgct cagccgcggg ccgtgcggct 780
cgcgggaccc ctgctccaac gtgacctgca gcttcggcag cacctgtgcg cgctcggccg 840
acgggctgac ggcctcgtgc ctgtgccccg cgacctgccg tggcgccccc gaggggaccg 900
tctgcggcag cgacggcgcc gactaccccg gcgagtgcca gctcctgcgc cgcgcctgcg 960
cccgccagga gaatgtcttc aagaagttcg acggcccttg tgacccctgt cagggcgccc 1020
tccctgaccc gagccgcagc tgccgtgtga acccgcgcac gcggcgccct gagatgctcc 1080
tacggcccga gagctgccct gcccggcagg cgccagtgtg tggggacgac ggagtcacct 1140
acgaaaacga ctgtgtcatg ggccgatcgg gggccgcccg gggtctcctc ctgcagaaag 1200
tgcgctccgg ccagtgccag ggtcgagacc agtgcccgga gccctgccgg ttcaatgccg 1260
tgtgcctgtc ccgccgtggc cgtccccgct gctcctgcga ccgcgtcacc tgtgacgggg 1320
cctacaggcc cgtgtgtgcc caggacgggc gcacgtatga cagtgattgc tggcggcagc 1380
aggctgagtg ccggcagcag cgtgccatcc ccagcaagca ccagggcccg tgtgaccagg 1440
ccccgtcccc atgcctcggg gtgcagtgtg catttggggc gacgtgtgct gtgaagaacg 1500
ggcaggcagc gtgtgaatgc ctgcaggcgt gctcgagcct ctacgatcct gtgtgcggca 1560
gcgacggcgt cacatacggc agcgcgtgcg agctggaggc cacggcctgt accctcgggc 1620
gggagatcca ggtggcgcgc aaaggaccct gtgaccgctg cgggcagtgc cgctttggag 1680
ccctgtgcga ggccgagacc gggcgctgcg tgtgcccctc tgaatgcgtg gctttggccc 1740
agcccgtgtg tggctccgac gggcacacgt accccagcga gtgcatgctg cacgtgcacg 1800
cctgcacaca ccagatcagc ctgcacgtgg cctcagctgg accctgtgag acctgtggag 1860
atgccgtgtg tgcttttggg gctgtgtgct ccgcagggca gtgtgtgtgt ccccggtgtg 1920
agcacccccc gcccggcccc gtgtgtggca gcgacggtgt cacctacggc agtgcctgcg 1980
agctacggga agccgcctgc ctccagcaga cacagatcga ggaggcccgg gcagggccgt 2040
gcgagcaggc cgagtgcggt tccggaggct ctggctctgg ggaggacggt gactgtgagc 2100
aggagctgtg ccggcagcgc ggtggcatct gggacgagga ctcggaggac gggccgtgtg 2160
tctgtgactt cagctgccag agtgtcccag gcagcccggt gtgcggctca gatggggtca 2220
cctacagcac cgagtgtgag ctgaagaagg ccaggtgtga gtcacagcga gggctctacg 2280
tagcggccca gggagcctgc cgaggcccca ccttcgcccc gctgccgcct gtggccccct 2340
tacactgtgc ccagacgccc tacggctgct gccaggacaa tatcaccgca gcccggggcg 2400
tgggcctggc tggctgcccc agtgcctgcc agtgcaaccc ccatggctct tacggcggca 2460
cctgtgaccc agccacaggc cagtgctcct gccgcccagg tgtggggggc ctcaggtgtg 2520
accgctgtga gcctggcttc tggaactttc gaggcatcgt caccgatggc cggagtggct 2580
gtacaccctg cagctgtgat ccccaaggcg ccgtgcggga tgactgtgag cagatgacgg 2640
ggctgtgctc gtgtaagccc ggggtggctg gacccaagtg tgggcagtgt ccagacggcc 2700
gtgccctggg ccccgcgggc tgtgaagctg acgcttctgc gcctgcgacc tgtgcggaga 2760
tgcgctgtga gttcggtgcg cggtgcgtgg aggagtctgg ctcagcccac tgtgtctgcc 2820
cgatgctcac ctgtccagag gccaacgcta ccaaggtctg tgggtcagat ggagtcacat 2880
acggcaacga gtgtcagctg aagaccatcg cctgccgcca gggcctgcaa atctctatcc 2940
agagcctggg cccgtgccag gaggctgttg ctcccagcac tcacccgaca tctgcctccg 3000
tgactgtgac caccccaggg ctcctcctga gccaggcact gccggccccc cccggcgccc 3060
tccccctggc tcccagcagt accgcacaca gccagaccac ccctccgccc tcatcacgac 3120
ctcggaccac tgccagcgtc cccaggacca ccgtgtggcc cgtgctgacg gtgcccccca 3180
cggcaccctc ccctgcaccc agcctggtgg cgtccgcctt tggtgaatct ggcagcactg 3240
atggaagcag cgatgaggaa ctgagcgggg accaggaggc cagtgggggt ggctctgggg 3300
ggctcgagcc cttggagggc agcagcgtgg ccacccctgg gccacctgtc gagagggctt 3360
cctgctacaa ctccgcgttg ggctgctgct ctgatgggaa gacgccctcg ctggacgcag 3420
agggctccaa ctgccccgcc accaaggtgt tccagggcgt cctggagctg gagggcgtcg 3480
agggccagga gctgttctac acgcccgaga tggctgaccc caagtcagaa ctgttcgggg 3540
agacagccag gagcattgag agcaccctgg acgacctctt ccggaattca gacgtcaaga 3600
aggattttcg gagtgtccgc ttgcgggacc tggggcccgg caaatccgtc cgcgccattg 3660
tggatgtgca ctttgacccc accacagcct tcagggcacc cgacgtggcc cgggccctgc 3720
tccggcagat ccaggtgtcc aggcgccggt ccttgggggt gaggcggccg ctgcaggagc 3780
acgtgcgatt tatggacttt gactggtttc ctgcgtttat cacgggggcc acgtcaggag 3840
ccattgctgc gggagccacg gccagagcca ccactgcatc gcgcctgccg tcctctgctg 3900
tgacccctcg ggccccgcac cccagtcaca caagccagcc cgttgccaag accacggcag 3960
cccccaccac acgtcggccc cccaccactg cccccagccg tgtgcccgga cgtcggcccc 4020
cggcccccca gcagcctcca aagccctgtg actcacagcc ctgcttccac ggggggacct 4080
gccaggactg ggcattgggc gggggcttca cctgcagctg cccggcaggc aggggaggcg 4140
ccgtctgtga gaaggtgctt ggcgcccctg tgccggcctt cgagggccgc tccttcctgg 4200
ccttccccac tctccgcgcc taccacacgc tgcgcctggc actggaattc cgggcgctgg 4260
agcctcaggg gctgctgctg tacaatggca acgcccgggg caaggacttc ctggcattgg 4320
cgctgctaga tggccgcgtg cagctcaggt ttgacacagg ttcggggccg gcggtgctga 4380
ccagtgccgt gccggtagag ccgggccagt ggcaccgcct ggagctgtcc cggcactggc 4440
gccggggcac cctctcggtg gatggtgaga cccctgttct gggcgagagt cccagtggca 4500
ccgacggcct caacctggac acagacctct ttgtgggcgg cgtacccgag gaccaggctg 4560
ccgtggcgct ggagcggacc ttcgtgggcg ccggcctgag ggggtgcatc cgtttgctgg 4620
acgtcaacaa ccagcgcctg gagcttggca ttgggccggg ggctgccacc cgaggctctg 4680
gcgtgggcga gtgcggggac cacccctgcc tgcccaaccc ctgccatggc ggggccccat 4740
gccagaacct ggaggctgga aggttccatt gccagtgccc gcccggccgc gtcggaccaa 4800
cctgtgccga tgagaagagc ccctgccagc ccaacccctg ccatggggcg gcgccctgcc 4860
gtgtgctgcc cgagggtggt gctcagtgcg agtgccccct ggggcgtgag ggcaccttct 4920
gccagacagc ctcggggcag gacggctctg ggcccttcct ggctgacttc aacggcttct 4980
cccacctgga gctgagaggc ctgcacacct ttgcacggga cctgggggag aagatggcgc 5040
tggaggtcgt gttcctggca cgaggcccca gcggcctcct gctctacaac gggcagaaga 5100
cggacggcaa gggggacttc gtgtcgctgg cactgcggga ccgccgcctg gagttccgct 5160
acgacctggg caagggggca gcggtcatca ggagcaggga gccagtcacc ctgggagcct 5220
ggaccagggt ctcactggag cgaaacggcc gcaagggtgc cctgcgtgtg ggcgacggcc 5280
cccgtgtgtt gggggagtcc ccggttccgc acaccgtcct caacctgaag gagccgctct 5340
acgtaggggg cgctcccgac ttcagcaagc tggcccgtgc tgctgccgtg tcctctggct 5400
tcgacggtgc catccagctg gtctccctcg gaggccgcca gctgctgacc ccggagcacg 5460
tgctgcggca ggtggacgtc acgtcctttg caggtcaccc ctgcacccgg gcctcaggcc 5520
acccctgcct caatggggcc tcctgcgtcc cgagggaggc tgcctatgtg tgcctgtgtc 5580
ccgggggatt ctcaggaccg cactgcgaga aggggctggt ggagaagtca gcgggggacg 5640
tggatacctt ggcctttgac gggcggacct ttgtcgagta cctcaacgct gtgaccgaga 5700
gcgagaaggc actgcagagc aaccactttg aactgagcct gcgcactgag gccacgcagg 5760
ggctggtgct ctggagtggc aaggccacgg agcgggcaga ctatgtggca ctggccattg 5820
tggacgggca cctgcaactg agctacaacc tgggctccca gcccgtggtg ctgcgttcca 5880
ccgtgcccgt caacaccaac cgctggttgc gggtcgtggc acatagggag cagagggaag 5940
gttccctgca ggtgggcaat gaggcccctg tgaccggctc ctccccgctg ggcgccacgc 6000
agctggacac tgatggagcc ctgtggcttg ggggcctgcc ggagctgccc gtgggcccag 6060
cactgcccaa ggcctacggc acaggctttg tgggctgctt gcgggacgtg gtggtgggcc 6120
ggcacccgct gcacctgctg gaggacgccg tcaccaagcc agagctgcgg ccctgcccca 6180
ccccatgagc tggcaccaga gccccgcgcc cgctgtaatt attttctatt tttgtaaact 6240
tgttgctttt tgatatgatt ttcttgcctg agtgttggcc ggagggactg ctggcccggc 6300
ctcccttccg tccaggcagc cgtgctgcag acagacctag tgccgaggga tggacaggcg 6360
aggtggcagc gtggagggct cggcgtggat ggcagcctca ggacacacac ccctgcctca 6420
aggtgctgag cccccgcctt gcactgcgcc tgccccacgg tgtccccgcc gggaagcagc 6480
cccggctcct gaatcaccct cgctccgtca ggcgggactc gtgtcccaga gaggaagggg 6540
ctgctgaggt ctgatggggc ccttcctccg ggtgacccca cagggccttt ccaagccccc 6600
atttgagctg ctccttcctg tgtgtgctct gggccctgcc tcggcctcct gcgccaatac 6660
tgtgacttcc aaacaatgtt actgctgggc acagctctgc gttgctcccg tgctgcctgc 6720
gccagcccca ggctgctgag gagcagaggc cagaccaggg ccgatctggg tgtcctgacc 6780
ctcagctggc cctgcccagc caccctggac gtgaccgtat ccctctgcca caccccaggc 6840
cctgcgaggg gctatcgaga ggagctcact gtgggatggg gttgacctct gccgcctgcc 6900
tgggtatctg ggcctggcca tggctgtgtt cttcatgtgt tgattttatt tgacccctgg 6960
agtggtgggt ctcatctttc ccatctcgcc tgagagcggc tgagggctgc ctcactgcaa 7020
atcctcccca cagcgtcagt gaaagtcgtc cttgtctcag aatgaccagg ggccagccag 7080
tgtctgacca aggtcaaggg gcaggtgcag aggtggcagg gatggctccg aagccagaaa 7140
tgccttaaac tgcaacgtcc cgtcccttcc ccacccccat cccatcccca cccccagccc 7200
cagcccagtc ctcctaggag caggacccga tgaagcgggc ggcggtgggg ctgggtgccg 7260
tgttactaac tctagtatgt ttctgtgtca atcgctgtga aataaagtct gaaaacttta 7320
aaagcaaaaa aaaaaaaaaa aaa                                         7343



<210> 2
<211> 2045
<212> PRT
<213> Homo sapiens

<400> 2
Met Ala Gly Arg Ser His Pro Gly Pro Leu Arg Pro Leu Leu Pro Leu
 1               5                  10                  15      
Leu Val Val Ala Ala Cys Val Leu Pro Gly Ala Gly Gly Thr Cys Pro
            20                  25                  30          
Glu Arg Ala Leu Glu Arg Arg Glu Glu Glu Ala Asn Val Val Leu Thr
        35                  40                  45              
Gly Thr Val Glu Glu Ile Leu Asn Val Asp Pro Val Gln His Thr Tyr
    50                  55                  60                  
Ser Cys Lys Val Arg Val Trp Arg Tyr Leu Lys Gly Lys Asp Leu Val
65                  70                  75                  80  
Ala Arg Glu Ser Leu Leu Asp Gly Gly Asn Lys Val Val Ile Ser Gly
                85                  90                  95      
Phe Gly Asp Pro Leu Ile Cys Asp Asn Gln Val Ser Thr Gly Asp Thr
            100                 105                 110         
Arg Ile Phe Phe Val Asn Pro Ala Pro Pro Tyr Leu Trp Pro Ala His
        115                 120                 125             
Lys Asn Glu Leu Met Leu Asn Ser Ser Leu Met Arg Ile Thr Leu Arg
    130                 135                 140                 
Asn Leu Glu Glu Val Glu Phe Cys Val Glu Asp Lys Pro Gly Thr His
145                 150                 155                 160 
Phe Thr Pro Val Pro Pro Thr Pro Pro Asp Ala Cys Arg Gly Met Leu
                165                 170                 175     
Cys Gly Phe Gly Ala Val Cys Glu Pro Asn Ala Glu Gly Pro Gly Arg
            180                 185                 190         
Ala Ser Cys Val Cys Lys Lys Ser Pro Cys Pro Ser Val Val Ala Pro
        195                 200                 205             
Val Cys Gly Ser Asp Ala Ser Thr Tyr Ser Asn Glu Cys Glu Leu Gln
    210                 215                 220                 
Arg Ala Gln Cys Ser Gln Gln Arg Arg Ile Arg Leu Leu Ser Arg Gly
225                 230                 235                 240 
Pro Cys Gly Ser Arg Asp Pro Cys Ser Asn Val Thr Cys Ser Phe Gly
                245                 250                 255     
Ser Thr Cys Ala Arg Ser Ala Asp Gly Leu Thr Ala Ser Cys Leu Cys
            260                 265                 270         
Pro Ala Thr Cys Arg Gly Ala Pro Glu Gly Thr Val Cys Gly Ser Asp
        275                 280                 285             
Gly Ala Asp Tyr Pro Gly Glu Cys Gln Leu Leu Arg Arg Ala Cys Ala
    290                 295                 300                 
Arg Gln Glu Asn Val Phe Lys Lys Phe Asp Gly Pro Cys Asp Pro Cys
305                 310                 315                 320 
Gln Gly Ala Leu Pro Asp Pro Ser Arg Ser Cys Arg Val Asn Pro Arg
                325                 330                 335     
Thr Arg Arg Pro Glu Met Leu Leu Arg Pro Glu Ser Cys Pro Ala Arg
            340                 345                 350         
Gln Ala Pro Val Cys Gly Asp Asp Gly Val Thr Tyr Glu Asn Asp Cys
        355                 360                 365             
Val Met Gly Arg Ser Gly Ala Ala Arg Gly Leu Leu Leu Gln Lys Val
    370                 375                 380                 
Arg Ser Gly Gln Cys Gln Gly Arg Asp Gln Cys Pro Glu Pro Cys Arg
385                 390                 395                 400 
Phe Asn Ala Val Cys Leu Ser Arg Arg Gly Arg Pro Arg Cys Ser Cys
                405                 410                 415     
Asp Arg Val Thr Cys Asp Gly Ala Tyr Arg Pro Val Cys Ala Gln Asp
            420                 425                 430         
Gly Arg Thr Tyr Asp Ser Asp Cys Trp Arg Gln Gln Ala Glu Cys Arg
        435                 440                 445             
Gln Gln Arg Ala Ile Pro Ser Lys His Gln Gly Pro Cys Asp Gln Ala
    450                 455                 460                 
Pro Ser Pro Cys Leu Gly Val Gln Cys Ala Phe Gly Ala Thr Cys Ala
465                 470                 475                 480 
Val Lys Asn Gly Gln Ala Ala Cys Glu Cys Leu Gln Ala Cys Ser Ser
                485                 490                 495     
Leu Tyr Asp Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly Ser Ala
            500                 505                 510         
Cys Glu Leu Glu Ala Thr Ala Cys Thr Leu Gly Arg Glu Ile Gln Val
        515                 520                 525             
Ala Arg Lys Gly Pro Cys Asp Arg Cys Gly Gln Cys Arg Phe Gly Ala
    530                 535                 540                 
Leu Cys Glu Ala Glu Thr Gly Arg Cys Val Cys Pro Ser Glu Cys Val
545                 550                 555                 560 
Ala Leu Ala Gln Pro Val Cys Gly Ser Asp Gly His Thr Tyr Pro Ser
                565                 570                 575     
Glu Cys Met Leu His Val His Ala Cys Thr His Gln Ile Ser Leu His
            580                 585                 590         
Val Ala Ser Ala Gly Pro Cys Glu Thr Cys Gly Asp Ala Val Cys Ala
        595                 600                 605             
Phe Gly Ala Val Cys Ser Ala Gly Gln Cys Val Cys Pro Arg Cys Glu
    610                 615                 620                 
His Pro Pro Pro Gly Pro Val Cys Gly Ser Asp Gly Val Thr Tyr Gly
625                 630                 635                 640 
Ser Ala Cys Glu Leu Arg Glu Ala Ala Cys Leu Gln Gln Thr Gln Ile
                645                 650                 655     
Glu Glu Ala Arg Ala Gly Pro Cys Glu Gln Ala Glu Cys Gly Ser Gly
            660                 665                 670         
Gly Ser Gly Ser Gly Glu Asp Gly Asp Cys Glu Gln Glu Leu Cys Arg
        675                 680                 685             
Gln Arg Gly Gly Ile Trp Asp Glu Asp Ser Glu Asp Gly Pro Cys Val
    690                 695                 700                 
Cys Asp Phe Ser Cys Gln Ser Val Pro Gly Ser Pro Val Cys Gly Ser
705                 710                 715                 720 
Asp Gly Val Thr Tyr Ser Thr Glu Cys Glu Leu Lys Lys Ala Arg Cys
                725                 730                 735     
Glu Ser Gln Arg Gly Leu Tyr Val Ala Ala Gln Gly Ala Cys Arg Gly
            740                 745                 750         
Pro Thr Phe Ala Pro Leu Pro Pro Val Ala Pro Leu His Cys Ala Gln
        755                 760                 765             
Thr Pro Tyr Gly Cys Cys Gln Asp Asn Ile Thr Ala Ala Arg Gly Val
    770                 775                 780                 
Gly Leu Ala Gly Cys Pro Ser Ala Cys Gln Cys Asn Pro His Gly Ser
785                 790                 795                 800 
Tyr Gly Gly Thr Cys Asp Pro Ala Thr Gly Gln Cys Ser Cys Arg Pro
                805                 810                 815     
Gly Val Gly Gly Leu Arg Cys Asp Arg Cys Glu Pro Gly Phe Trp Asn
            820                 825                 830         
Phe Arg Gly Ile Val Thr Asp Gly Arg Ser Gly Cys Thr Pro Cys Ser
        835                 840                 845             
Cys Asp Pro Gln Gly Ala Val Arg Asp Asp Cys Glu Gln Met Thr Gly
    850                 855                 860                 
Leu Cys Ser Cys Lys Pro Gly Val Ala Gly Pro Lys Cys Gly Gln Cys
865                 870                 875                 880 
Pro Asp Gly Arg Ala Leu Gly Pro Ala Gly Cys Glu Ala Asp Ala Ser
                885                 890                 895     
Ala Pro Ala Thr Cys Ala Glu Met Arg Cys Glu Phe Gly Ala Arg Cys
            900                 905                 910         
Val Glu Glu Ser Gly Ser Ala His Cys Val Cys Pro Met Leu Thr Cys
        915                 920                 925             
Pro Glu Ala Asn Ala Thr Lys Val Cys Gly Ser Asp Gly Val Thr Tyr
    930                 935                 940                 
Gly Asn Glu Cys Gln Leu Lys Thr Ile Ala Cys Arg Gln Gly Leu Gln
945                 950                 955                 960 
Ile Ser Ile Gln Ser Leu Gly Pro Cys Gln Glu Ala Val Ala Pro Ser
                965                 970                 975     
Thr His Pro Thr Ser Ala Ser Val Thr Val Thr Thr Pro Gly Leu Leu
            980                 985                 990         
Leu Ser Gln Ala Leu Pro Ala Pro Pro Gly Ala Leu Pro Leu Ala Pro
        995                 1000                1005            
Ser Ser Thr Ala His Ser Gln Thr Thr Pro Pro Pro Ser Ser Arg Pro
    1010                1015                1020                
Arg Thr Thr Ala Ser Val Pro Arg Thr Thr Val Trp Pro Val Leu Thr
1025                1030                1035                1040
Val Pro Pro Thr Ala Pro Ser Pro Ala Pro Ser Leu Val Ala Ser Ala
                1045                1050                1055    
Phe Gly Glu Ser Gly Ser Thr Asp Gly Ser Ser Asp Glu Glu Leu Ser
            1060                1065                1070        
Gly Asp Gln Glu Ala Ser Gly Gly Gly Ser Gly Gly Leu Glu Pro Leu
        1075                1080                1085            
Glu Gly Ser Ser Val Ala Thr Pro Gly Pro Pro Val Glu Arg Ala Ser
    1090                1095                1100                
Cys Tyr Asn Ser Ala Leu Gly Cys Cys Ser Asp Gly Lys Thr Pro Ser
1105                1110                1115                1120
Leu Asp Ala Glu Gly Ser Asn Cys Pro Ala Thr Lys Val Phe Gln Gly
                1125                1130                1135    
Val Leu Glu Leu Glu Gly Val Glu Gly Gln Glu Leu Phe Tyr Thr Pro
            1140                1145                1150        
Glu Met Ala Asp Pro Lys Ser Glu Leu Phe Gly Glu Thr Ala Arg Ser
        1155                1160                1165            
Ile Glu Ser Thr Leu Asp Asp Leu Phe Arg Asn Ser Asp Val Lys Lys
    1170                1175                1180                
Asp Phe Arg Ser Val Arg Leu Arg Asp Leu Gly Pro Gly Lys Ser Val
1185                1190                1195                1200
Arg Ala Ile Val Asp Val His Phe Asp Pro Thr Thr Ala Phe Arg Ala
                1205                1210                1215    
Pro Asp Val Ala Arg Ala Leu Leu Arg Gln Ile Gln Val Ser Arg Arg
            1220                1225                1230        
Arg Ser Leu Gly Val Arg Arg Pro Leu Gln Glu His Val Arg Phe Met
        1235                1240                1245            
Asp Phe Asp Trp Phe Pro Ala Phe Ile Thr Gly Ala Thr Ser Gly Ala
    1250                1255                1260                
Ile Ala Ala Gly Ala Thr Ala Arg Ala Thr Thr Ala Ser Arg Leu Pro
1265                1270                1275                1280
Ser Ser Ala Val Thr Pro Arg Ala Pro His Pro Ser His Thr Ser Gln
                1285                1290                1295    
Pro Val Ala Lys Thr Thr Ala Ala Pro Thr Thr Arg Arg Pro Pro Thr
            1300                1305                1310        
Thr Ala Pro Ser Arg Val Pro Gly Arg Arg Pro Pro Ala Pro Gln Gln
        1315                1320                1325            
Pro Pro Lys Pro Cys Asp Ser Gln Pro Cys Phe His Gly Gly Thr Cys
    1330                1335                1340                
Gln Asp Trp Ala Leu Gly Gly Gly Phe Thr Cys Ser Cys Pro Ala Gly
1345                1350                1355                1360
Arg Gly Gly Ala Val Cys Glu Lys Val Leu Gly Ala Pro Val Pro Ala
                1365                1370                1375    
Phe Glu Gly Arg Ser Phe Leu Ala Phe Pro Thr Leu Arg Ala Tyr His
            1380                1385                1390        
Thr Leu Arg Leu Ala Leu Glu Phe Arg Ala Leu Glu Pro Gln Gly Leu
        1395                1400                1405            
Leu Leu Tyr Asn Gly Asn Ala Arg Gly Lys Asp Phe Leu Ala Leu Ala
    1410                1415                1420                
Leu Leu Asp Gly Arg Val Gln Leu Arg Phe Asp Thr Gly Ser Gly Pro
1425                1430                1435                1440
Ala Val Leu Thr Ser Ala Val Pro Val Glu Pro Gly Gln Trp His Arg
                1445                1450                1455    
Leu Glu Leu Ser Arg His Trp Arg Arg Gly Thr Leu Ser Val Asp Gly
            1460                1465                1470        
Glu Thr Pro Val Leu Gly Glu Ser Pro Ser Gly Thr Asp Gly Leu Asn
        1475                1480                1485            
Leu Asp Thr Asp Leu Phe Val Gly Gly Val Pro Glu Asp Gln Ala Ala
    1490                1495                1500                
Val Ala Leu Glu Arg Thr Phe Val Gly Ala Gly Leu Arg Gly Cys Ile
1505                1510                1515                1520
Arg Leu Leu Asp Val Asn Asn Gln Arg Leu Glu Leu Gly Ile Gly Pro
                1525                1530                1535    
Gly Ala Ala Thr Arg Gly Ser Gly Val Gly Glu Cys Gly Asp His Pro
            1540                1545                1550        
Cys Leu Pro Asn Pro Cys His Gly Gly Ala Pro Cys Gln Asn Leu Glu
        1555                1560                1565            
Ala Gly Arg Phe His Cys Gln Cys Pro Pro Gly Arg Val Gly Pro Thr
    1570                1575                1580                
Cys Ala Asp Glu Lys Ser Pro Cys Gln Pro Asn Pro Cys His Gly Ala
1585                1590                1595                1600
Ala Pro Cys Arg Val Leu Pro Glu Gly Gly Ala Gln Cys Glu Cys Pro
                1605                1610                1615    
Leu Gly Arg Glu Gly Thr Phe Cys Gln Thr Ala Ser Gly Gln Asp Gly
            1620                1625                1630        
Ser Gly Pro Phe Leu Ala Asp Phe Asn Gly Phe Ser His Leu Glu Leu
        1635                1640                1645            
Arg Gly Leu His Thr Phe Ala Arg Asp Leu Gly Glu Lys Met Ala Leu
    1650                1655                1660                
Glu Val Val Phe Leu Ala Arg Gly Pro Ser Gly Leu Leu Leu Tyr Asn
1665                1670                1675                1680
Gly Gln Lys Thr Asp Gly Lys Gly Asp Phe Val Ser Leu Ala Leu Arg
                1685                1690                1695    
Asp Arg Arg Leu Glu Phe Arg Tyr Asp Leu Gly Lys Gly Ala Ala Val
            1700                1705                1710        
Ile Arg Ser Arg Glu Pro Val Thr Leu Gly Ala Trp Thr Arg Val Ser
        1715                1720                1725            
Leu Glu Arg Asn Gly Arg Lys Gly Ala Leu Arg Val Gly Asp Gly Pro
    1730                1735                1740                
Arg Val Leu Gly Glu Ser Pro Val Pro His Thr Val Leu Asn Leu Lys
1745                1750                1755                1760
Glu Pro Leu Tyr Val Gly Gly Ala Pro Asp Phe Ser Lys Leu Ala Arg
                1765                1770                1775    
Ala Ala Ala Val Ser Ser Gly Phe Asp Gly Ala Ile Gln Leu Val Ser
            1780                1785                1790        
Leu Gly Gly Arg Gln Leu Leu Thr Pro Glu His Val Leu Arg Gln Val
        1795                1800                1805            
Asp Val Thr Ser Phe Ala Gly His Pro Cys Thr Arg Ala Ser Gly His
    1810                1815                1820                
Pro Cys Leu Asn Gly Ala Ser Cys Val Pro Arg Glu Ala Ala Tyr Val
1825                1830                1835                1840
Cys Leu Cys Pro Gly Gly Phe Ser Gly Pro His Cys Glu Lys Gly Leu
                1845                1850                1855    
Val Glu Lys Ser Ala Gly Asp Val Asp Thr Leu Ala Phe Asp Gly Arg
            1860                1865                1870        
Thr Phe Val Glu Tyr Leu Asn Ala Val Thr Glu Ser Glu Lys Ala Leu
        1875                1880                1885            
Gln Ser Asn His Phe Glu Leu Ser Leu Arg Thr Glu Ala Thr Gln Gly
    1890                1895                1900                
Leu Val Leu Trp Ser Gly Lys Ala Thr Glu Arg Ala Asp Tyr Val Ala
1905                1910                1915                1920
Leu Ala Ile Val Asp Gly His Leu Gln Leu Ser Tyr Asn Leu Gly Ser
                1925                1930                1935    
Gln Pro Val Val Leu Arg Ser Thr Val Pro Val Asn Thr Asn Arg Trp
            1940                1945                1950        
Leu Arg Val Val Ala His Arg Glu Gln Arg Glu Gly Ser Leu Gln Val
        1955                1960                1965            
Gly Asn Glu Ala Pro Val Thr Gly Ser Ser Pro Leu Gly Ala Thr Gln
    1970                1975                1980                
Leu Asp Thr Asp Gly Ala Leu Trp Leu Gly Gly Leu Pro Glu Leu Pro
1985                1990                1995                2000
Val Gly Pro Ala Leu Pro Lys Ala Tyr Gly Thr Gly Phe Val Gly Cys
                2005                2010                2015    
Leu Arg Asp Val Val Val Gly Arg His Pro Leu His Leu Leu Glu Asp
            2020                2025                2030        
Ala Val Thr Lys Pro Glu Leu Arg Pro Cys Pro Thr Pro
        2035                2040                2045


<210> 3
<211> 8244
<212> DNA
<213> Homo sapiens

<400> 3
gtggccgggg ctgcggcgcg gggggcgggg cggtcgggcc cgggacaccc cctcccggtc 60
ccctggcggg gcagcgtcgg ctctggcagc actggaggcg gcggcggccc gagggcgact 120
tgcggggcgc gcaggccgcc gtgcacccgg gacgcttccc cctcggggac cctccgcggg 180
cttctccgcc gcgccgtccg gcgggagccg gcgggacccc gggcgagcgg cgcgggcggc 240
accatgaggc ggcagtgggg cgcgctgctg cttggcgccc tgctctgcgc acacggcctg 300
gccagcagcc ccgagtgtgc ttgtggtcgg agccacttca catgtgcagt gagtgctctt 360
ggagagtgta cctgcatccc tgcccagtgg cagtgtgatg gagacaatga ctgcggggac 420
cacagcgatg aggatggatg tatactacct acctgttccc ctcttgactt tcactgtgac 480
aatggcaagt gcatccgccg ctcctgggtg tgtgacgggg acaacgactg tgaggatgac 540
tcggatgagc aggactgtcc cccccgggag tgtgaggagg acgagtttcc ctgccagaat 600
ggctactgca tccggagtct gtggcactgc gatggtgaca atgactgtgg cgacaacagc 660
gatgagcagt gtgacatgcg caagtgctcc gacaaggagt tccgctgtag tgacggaagc 720
tgcattgctg agcattggta ctgcgacggt gacaccgact gcaaagatgg ctccgatgag 780
gagaactgtc cctcagcagt gccagcgccc ccctgcaacc tggaggagtt ccagtgtgcc 840
tatggacgct gcatcctcga catctaccac tgcgatggcg acgatgactg tggagactgg 900
tcagacgagt ctgactgctc ctcccaccag ccctgccgct ctggggagtt catgtgtgac 960
agtggcctgt gcatcaatgc aggctggcgc tgcgatggtg acgcggactg tgatgaccag 1020
tctgatgagc gcaactgcac cacctccatg tgtacggcag aacagttccg ctgtcactca 1080
ggccgctgtg tccgcctgtc ctggcgctgt gatggggagg acgactgtgc agacaacagc 1140
gatgaagaga actgtgagaa tacaggaagc ccccaatgtg ccttggacca gttcctgtgt 1200
tggaatgggc gctgcattgg gcagaggaag ctgtgcaacg gggtcaacga ctgtggtgac 1260
aacagcgacg aaagcccaca gcagaattgc cggccccgga cgggtgagga gaactgcaat 1320
gttaacaacg gtggctgtgc ccagaagtgc cagatggtgc ggggggcagt gcagtgtacc 1380
tgccacacag gctaccggct cacagaggat gggcacacgt gccaagatgt gaatgaatgt 1440
gccgaggagg ggtattgcag ccagggctgc accaacagcg aaggggcttt ccaatgctgg 1500
tgtgaaacag gctatgaact acggcccgac cggcgcagct gcaaggctct ggggccagag 1560
cctgtgctgc tgttcgccaa tcgcatcgac atccggcagg tgctgccaca ccgctctgag 1620
tacacactgc tgcttaacaa cctggagaat gccattgccc ttgatttcca ccaccgccgc 1680
gagcttgtct tctggtcaga tgtcaccctg gaccggatcc tccgtgccaa cctcaacggc 1740
agcaacgtgg aggaggttgt gtctactggg ctggagagcc cagggggcct ggctgtggat 1800
tgggtccatg acaaactcta ctggaccgac tcaggcacct cgaggattga ggtggccaat 1860
ctggatgggg cccaccggaa agtgttgctg tggcagaacc tggagaagcc ccgggccatt 1920
gccttgcatc ccatggaggg taccatttac tggacagact ggggcaacac cccccgtatt 1980
gaggcctcca gcatggatgg ctctggacgc cgcatcattg ccgataccca tctcttctgg 2040
cccaatggcc tcaccatcga ctatgccggg cgccgtatgt actgggtgga tgctaagcac 2100
catgtcatcg agagggccaa tctggatggg agtcaccgta aggctgtcat tagccagggc 2160
ctcccgcatc ccttcgccat cacagtgttt gaagacagcc tgtactggac agactggcac 2220
accaagagca tcaatagcgc taacaaattt acggggaaga accaggaaat cattcgcaac 2280
aaactccact tccctatgga catccacacc ttgcaccccc agcgccaacc tgcagggaaa 2340
aaccgctgtg gggacaacaa cggaggctgc acgcacctgt gtctgcccag tggccagaac 2400
tacacctgtg cctgccccac tggcttccgc aagatcagca gccacgcctg tgcccagagt 2460
cttgacaagt tcctgctttt tgcccgaagg atggacatcc gtcgaatcag ctttgacaca 2520
gaggacctgt ctgatgatgt catcccactg gctgacgtgc gcagtgctgt ggcccttgac 2580
tgggactccc gggatgacca cgtgtactgg acagatgtca gcactgatac catcagcagg 2640
gccaagtggg atggaacagg acaggaggtg gtagtggata ccagtttgga gagcccagct 2700
ggcctggcca ttgattgggt caccaacaaa ctgtactgga cagatgcagg tacagaccgg 2760
attgaagtag ccaacacaga tggcagcatg agaacagtac tcatctggga gaaccttgat 2820
cgtcctcggg acatcgtggt ggaacccatg ggcgggtaca tgtattggac tgactggggt 2880
gcgagcccca agattgaacg agctggcatg gatgcctcag gccgccaagt cattatctct 2940
tctaatctga cctggcctaa tgggttagct attgattatg ggtcccagcg tctatactgg 3000
gctgacgccg gcatgaagac aattgaattt gctggactgg atggcagtaa gaggaaggtg 3060
ctgattggaa gccagctccc ccacccattt gggctgaccc tctatggaga gcgcatctat 3120
tggactgact ggcagaccaa gagcatacag agcgctgacc ggctgacagg gctggaccgg 3180
gagactctgc aggagaacct ggaaaaccta atggacatcc atgtcttcca ccgccgccgg 3240
cccccagtgt ctacaccatg tgctatggag aatggcggct gtagccacct gtgtcttagg 3300
tccccaaatc caagcggatt cagctgtacc tgccccacag gcatcaacct gctgtctgat 3360
ggcaagacct gctcaccagg catgaacagt ttcctcatct tcgccaggag gatagacatt 3420
cgcatggtct ccctggacat cccttatttt gctgatgtgg tggtaccaat caacattacc 3480
atgaagaaca ccattgccat tggagtagac ccccaggaag gaaaggtgta ctggtctgac 3540
agcacactgc acaggatcag tcgtgccaat ctggatggct cacagcatga ggacatcatc 3600
accacagggc tacagaccac agatgggctc gcggttgatg ccattggccg gaaagtatac 3660
tggacagaca cgggaacaaa ccggattgaa gtgggcaacc tggacgggtc catgcggaaa 3720
gtgttggtgt ggcagaacct tgacagtccc cgggccatcg tactgtacca tgagatgggg 3780
tttatgtact ggacagactg gggggagaat gccaagttag agcggtccgg aatggatggc 3840
tcagaccgcg cggtgctcat caacaacaac ctaggatggc ccaatggact gactgtggac 3900
aaggccagct cccaactgct atgggccgat gcccacaccg agcgaattga ggctgctgac 3960
ctgaatggtg ccaatcggca tacattggtg tcaccggtgc agcacccata tggcctcacc 4020
ctgctcgact cctatatcta ctggactgac tggcagactc ggagcatcca ccgtgctgac 4080
aagggtactg gcagcaatgt catcctcgtg aggtccaacc tgccaggcct catggacatg 4140
caggctgtgg accgggcaca gccactaggt tttaacaagt gcggctcgag aaatggcggc 4200
tgctcccacc tctgcttgcc tcggccttct ggcttctcct gtgcctgccc cactggcatc 4260
cagctgaagg gagatgggaa gacctgtgat ccctctcctg agacctacct gctcttctcc 4320
agccgtggct ccatccggcg tatctcactg gacaccagtg accacaccga tgtgcatgtc 4380
cctgttcctg agctcaacaa tgtcatctcc ctggactatg acagcgtgga tggaaaggtc 4440
tattacacag atgtgttcct ggatgttatc aggcgagcag acctgaacgg cagcaacatg 4500
gagacagtga tcgggcgagg gctgaagacc actgacgggc tggcagtgga ctgggtggcc 4560
aggaacctgt actggacaga cacaggtcga aataccattg aggcgtccag gctggatggt 4620
tcctgccgca aagtactgat caacaatagc ctggatgagc cccgggccat tgctgttttc 4680
cccaggaagg ggtacctctt ctggacagac tggggccaca ttgccaagat cgaacgggca 4740
aacttggatg gttctgagcg gaaggtcctc atcaacacag acctgggttg gcccaatggc 4800
cttaccctgg actatgatac ccgcaggatc tactgggtgg atgcgcatct ggaccggatc 4860
gagagtgctg acctcaatgg gaaactgcgg caggtcttgg tcagccatgt gtcccacccc 4920
tttgccctca cacagcaaga caggtggatc tactggacag actggcagac caagtcaatc 4980
cagcgtgttg acaaatactc aggccggaac aaggagacag tgctggcaaa tgtggaagga 5040
ctcatggata tcatcgtggt ttcccctcag cggcagacag ggaccaatgc ctgtggtgtg 5100
aacaatggtg gctgcaccca cctctgcttt gccagagcct cggacttcgt atgtgcctgt 5160
cctgacgaac ctgatagccg gccctgctcc cttgtgcctg gcctggtacc accagctcct 5220
agggctactg gcatgagtga aaagagccca gtgctaccca acacaccacc taccaccttg 5280
tattcttcaa ccacccggac ccgcacgtct ctggaggagg tggaaggaag atgctctgaa 5340
agggatgcca ggctgggcct ctgtgcacgt tccaatgacg ctgttcctgc tgctccaggg 5400
gaaggacttc atatcagcta cgccattggt ggactcctca gtattctgct gattttggtg 5460
gtgattgcag ctttgatgct gtacagacac aaaaaatcca agttcactga tcctggaatg 5520
gggaacctca cctacagcaa cccctcctac cgaacatcca cacaggaagt gaagattgaa 5580
gcaatcccca aaccagccat gtacaaccag ctgtgctata agaaagaggg agggcctgac 5640
cataactaca ccaaggagaa gatcaagatc gtagagggaa tctgcctcct gtctggggat 5700
gatgctgagt gggatgacct caagcaactg cgaagctcac gggggggcct cctccgggat 5760
catgtatgca tgaagacaga cacggtgtcc atccaggcca gctctggctc cctggatgac 5820
acagagacgg agcagctgtt acaggaagag cagtctgagt gtagcagcgt ccatactgca 5880
gccactccag aaagacgagg ctctctgcca gacacgggct ggaaacatga acgcaagctc 5940
tcctcagaga gccaggtcta aatgcccaca ttctcttccc tgcctgcctg ttccttctcc 6000
tttatggacg tctagtcctt gtgctcgctt acaccgcagg ccccgcttct gtgtgcttgt 6060
cctcctcctc ctcccacccc ataactgttc ctaagccttc accggagctg tttaccacgt 6120
gagtccataa ctacctgtgc acaagaaatg atggcacatc acgagaattt agacctggat 6180
tttaccatga acctcacatc ttgtactcca tcctgggccc cctgaaactg cttattcgtg 6240
attcctcacc agcgtagagc tccacctccc ctttccccag taccctcagt gcctgcttct 6300
cagtgctgat gcagctgatg acccaggact gcgctctgcc ccatcacagc cagcatgact 6360
gcttctctga gagaacttgc ccatcagggg ctgggacatg ggggtgtggg taaagacagg 6420
gatgaaggat agaggctgag agaagaagga agaatcagcc cagcaggtat gggcatctgg 6480
gaaacctcca gcctcaagtg tgttggtaac atgaaaaagc tttggggggt agttggatct 6540
gggtgtctgg tccattgctg gcagtggaca ttattcttgc cctaagagac actgcctttt 6600
cagcagcaga tactggtgag atgggggtgg ctcaggctgt tcttcctcct cctagaatgt 6660
ctggagctgt ttctacattc agataactgg gtcccctatc acaaggctac tggctaatag 6720
gaattccctc ctggtgccac cactggccag tacctttcct aagtctttgc tcaaattaac 6780
caggttgtga gccagtggct tgagtgaatg ttaggccttg ggggctgagt ctctgaaaag 6840
tctaagaagc tctgcctaga ccaaatatgg tatacctcct gacccctctc tccctcatgt 6900
cctgggattc tggggaagag acctagaaac aagctttcaa agaaaaacca gaagttgtca 6960
taaatggtca gaaagaacga tcaggttgga gacttgggaa acccagggcc taaagagaag 7020
tatccatgag ggtcaaactt cctgttgaac ttcctatgtt ctttctcaag tgctcaggga 7080
tctaagttag tggacagcaa gcctgtggct acggggtggt gatgttcctc ttccagctgt 7140
cccctcagct aaggggctta gtttccatgt gggatgccat cacttggttc atgctcattc 7200
acacaaaggg cacgtgtctc agcctggtat cagggaaatt gagacttatt tttgccctaa 7260
aacgtctccc tagctgttct tcgtggggtt tttttgtttg tttttttgcc taatttgctt 7320
tttctgacca agccttgtgg caccagcaat ctccaaagtc ctgtggtggg agggctgaat 7380
aaataaaaat acaaagaggt gggtaaggag taggaaggta gagagcacca ctgatgaggc 7440
cctcctagcc catggcagac ccagacctct tctcccccag gaattagaag tggcaggaga 7500
gaacaacagg ggctgggaat ggaggggaga atttctaggg gaagtttcct gagttgaaac 7560
ttctcctgtg gttactggta ttgagaaatc agctaccaaa gtgaaaaagg acaagatcaa 7620
ttcttttcta gtcagttcta agactgctag agagagatac caggccctta gccttgctct 7680
cagtagcgtc agccccagtt ctgagcctcc ccacattaca cttaacaagc agtaaaggag 7740
tgagcacttt gggtccttag actcatgtct ggggaggaag agcaagtaga aaagtggcat 7800
tttcttgatt ggaaaggggg aaggatctta ttgcacttgg gctgttcaga atgtagaaag 7860
gacatatttg aggaagtatc tatttgagca ctgatttact ctgtaaaaag caaaatctct 7920
ctgtcctaaa ctaatggaag cgattctccc atgctcatgt gtaatggttt taacgttact 7980
cactggagag attggacttt ctggagttat ttaaccacta tgttcagtat tttaggactt 8040
tatgataatt taatataaat ttagcttttc ttaatcacct tgcctggctt ggagtcatga 8100
ctaatcctgc acctgctctg tctggcagac ccatgctgtg gaaaacctgc ttacagacat 8160
cacttttaag tcctttgtgg atgtgggcac agtgaagagc aataaagagt gtgaggttcc 8220
tgctggaaaa aaaaaaaaaa aaaa                                        8244



<210> 4
<211> 1905
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Arg Gln Trp Gly Ala Leu Leu Leu Gly Ala Leu Leu Cys Ala
 1               5                  10                  15      
His Gly Leu Ala Ser Ser Pro Glu Cys Ala Cys Gly Arg Ser His Phe
            20                  25                  30          
Thr Cys Ala Val Ser Ala Leu Gly Glu Cys Thr Cys Ile Pro Ala Gln
        35                  40                  45              
Trp Gln Cys Asp Gly Asp Asn Asp Cys Gly Asp His Ser Asp Glu Asp
    50                  55                  60                  
Gly Cys Ile Leu Pro Thr Cys Ser Pro Leu Asp Phe His Cys Asp Asn
65                  70                  75                  80  
Gly Lys Cys Ile Arg Arg Ser Trp Val Cys Asp Gly Asp Asn Asp Cys
                85                  90                  95      
Glu Asp Asp Ser Asp Glu Gln Asp Cys Pro Pro Arg Glu Cys Glu Glu
            100                 105                 110         
Asp Glu Phe Pro Cys Gln Asn Gly Tyr Cys Ile Arg Ser Leu Trp His
        115                 120                 125             
Cys Asp Gly Asp Asn Asp Cys Gly Asp Asn Ser Asp Glu Gln Cys Asp
    130                 135                 140                 
Met Arg Lys Cys Ser Asp Lys Glu Phe Arg Cys Ser Asp Gly Ser Cys
145                 150                 155                 160 
Ile Ala Glu His Trp Tyr Cys Asp Gly Asp Thr Asp Cys Lys Asp Gly
                165                 170                 175     
Ser Asp Glu Glu Asn Cys Pro Ser Ala Val Pro Ala Pro Pro Cys Asn
            180                 185                 190         
Leu Glu Glu Phe Gln Cys Ala Tyr Gly Arg Cys Ile Leu Asp Ile Tyr
        195                 200                 205             
His Cys Asp Gly Asp Asp Asp Cys Gly Asp Trp Ser Asp Glu Ser Asp
    210                 215                 220                 
Cys Ser Ser His Gln Pro Cys Arg Ser Gly Glu Phe Met Cys Asp Ser
225                 230                 235                 240 
Gly Leu Cys Ile Asn Ala Gly Trp Arg Cys Asp Gly Asp Ala Asp Cys
                245                 250                 255     
Asp Asp Gln Ser Asp Glu Arg Asn Cys Thr Thr Ser Met Cys Thr Ala
            260                 265                 270         
Glu Gln Phe Arg Cys His Ser Gly Arg Cys Val Arg Leu Ser Trp Arg
        275                 280                 285             
Cys Asp Gly Glu Asp Asp Cys Ala Asp Asn Ser Asp Glu Glu Asn Cys
    290                 295                 300                 
Glu Asn Thr Gly Ser Pro Gln Cys Ala Leu Asp Gln Phe Leu Cys Trp
305                 310                 315                 320 
Asn Gly Arg Cys Ile Gly Gln Arg Lys Leu Cys Asn Gly Val Asn Asp
                325                 330                 335     
Cys Gly Asp Asn Ser Asp Glu Ser Pro Gln Gln Asn Cys Arg Pro Arg
            340                 345                 350         
Thr Gly Glu Glu Asn Cys Asn Val Asn Asn Gly Gly Cys Ala Gln Lys
        355                 360                 365             
Cys Gln Met Val Arg Gly Ala Val Gln Cys Thr Cys His Thr Gly Tyr
    370                 375                 380                 
Arg Leu Thr Glu Asp Gly His Thr Cys Gln Asp Val Asn Glu Cys Ala
385                 390                 395                 400 
Glu Glu Gly Tyr Cys Ser Gln Gly Cys Thr Asn Ser Glu Gly Ala Phe
                405                 410                 415     
Gln Cys Trp Cys Glu Thr Gly Tyr Glu Leu Arg Pro Asp Arg Arg Ser
            420                 425                 430         
Cys Lys Ala Leu Gly Pro Glu Pro Val Leu Leu Phe Ala Asn Arg Ile
        435                 440                 445             
Asp Ile Arg Gln Val Leu Pro His Arg Ser Glu Tyr Thr Leu Leu Leu
    450                 455                 460                 
Asn Asn Leu Glu Asn Ala Ile Ala Leu Asp Phe His His Arg Arg Glu
465                 470                 475                 480 
Leu Val Phe Trp Ser Asp Val Thr Leu Asp Arg Ile Leu Arg Ala Asn
                485                 490                 495     
Leu Asn Gly Ser Asn Val Glu Glu Val Val Ser Thr Gly Leu Glu Ser
            500                 505                 510         
Pro Gly Gly Leu Ala Val Asp Trp Val His Asp Lys Leu Tyr Trp Thr
        515                 520                 525             
Asp Ser Gly Thr Ser Arg Ile Glu Val Ala Asn Leu Asp Gly Ala His
    530                 535                 540                 
Arg Lys Val Leu Leu Trp Gln Asn Leu Glu Lys Pro Arg Ala Ile Ala
545                 550                 555                 560 
Leu His Pro Met Glu Gly Thr Ile Tyr Trp Thr Asp Trp Gly Asn Thr
                565                 570                 575     
Pro Arg Ile Glu Ala Ser Ser Met Asp Gly Ser Gly Arg Arg Ile Ile
            580                 585                 590         
Ala Asp Thr His Leu Phe Trp Pro Asn Gly Leu Thr Ile Asp Tyr Ala
        595                 600                 605             
Gly Arg Arg Met Tyr Trp Val Asp Ala Lys His His Val Ile Glu Arg
    610                 615                 620                 
Ala Asn Leu Asp Gly Ser His Arg Lys Ala Val Ile Ser Gln Gly Leu
625                 630                 635                 640 
Pro His Pro Phe Ala Ile Thr Val Phe Glu Asp Ser Leu Tyr Trp Thr
                645                 650                 655     
Asp Trp His Thr Lys Ser Ile Asn Ser Ala Asn Lys Phe Thr Gly Lys
            660                 665                 670         
Asn Gln Glu Ile Ile Arg Asn Lys Leu His Phe Pro Met Asp Ile His
        675                 680                 685             
Thr Leu His Pro Gln Arg Gln Pro Ala Gly Lys Asn Arg Cys Gly Asp
    690                 695                 700                 
Asn Asn Gly Gly Cys Thr His Leu Cys Leu Pro Ser Gly Gln Asn Tyr
705                 710                 715                 720 
Thr Cys Ala Cys Pro Thr Gly Phe Arg Lys Ile Ser Ser His Ala Cys
                725                 730                 735     
Ala Gln Ser Leu Asp Lys Phe Leu Leu Phe Ala Arg Arg Met Asp Ile
            740                 745                 750         
Arg Arg Ile Ser Phe Asp Thr Glu Asp Leu Ser Asp Asp Val Ile Pro
        755                 760                 765             
Leu Ala Asp Val Arg Ser Ala Val Ala Leu Asp Trp Asp Ser Arg Asp
    770                 775                 780                 
Asp His Val Tyr Trp Thr Asp Val Ser Thr Asp Thr Ile Ser Arg Ala
785                 790                 795                 800 
Lys Trp Asp Gly Thr Gly Gln Glu Val Val Val Asp Thr Ser Leu Glu
                805                 810                 815     
Ser Pro Ala Gly Leu Ala Ile Asp Trp Val Thr Asn Lys Leu Tyr Trp
            820                 825                 830         
Thr Asp Ala Gly Thr Asp Arg Ile Glu Val Ala Asn Thr Asp Gly Ser
        835                 840                 845             
Met Arg Thr Val Leu Ile Trp Glu Asn Leu Asp Arg Pro Arg Asp Ile
    850                 855                 860                 
Val Val Glu Pro Met Gly Gly Tyr Met Tyr Trp Thr Asp Trp Gly Ala
865                 870                 875                 880 
Ser Pro Lys Ile Glu Arg Ala Gly Met Asp Ala Ser Gly Arg Gln Val
                885                 890                 895     
Ile Ile Ser Ser Asn Leu Thr Trp Pro Asn Gly Leu Ala Ile Asp Tyr
            900                 905                 910         
Gly Ser Gln Arg Leu Tyr Trp Ala Asp Ala Gly Met Lys Thr Ile Glu
        915                 920                 925             
Phe Ala Gly Leu Asp Gly Ser Lys Arg Lys Val Leu Ile Gly Ser Gln
    930                 935                 940                 
Leu Pro His Pro Phe Gly Leu Thr Leu Tyr Gly Glu Arg Ile Tyr Trp
945                 950                 955                 960 
Thr Asp Trp Gln Thr Lys Ser Ile Gln Ser Ala Asp Arg Leu Thr Gly
                965                 970                 975     
Leu Asp Arg Glu Thr Leu Gln Glu Asn Leu Glu Asn Leu Met Asp Ile
            980                 985                 990         
His Val Phe His Arg Arg Arg Pro Pro Val Ser Thr Pro Cys Ala Met
        995                 1000                1005            
Glu Asn Gly Gly Cys Ser His Leu Cys Leu Arg Ser Pro Asn Pro Ser
    1010                1015                1020                
Gly Phe Ser Cys Thr Cys Pro Thr Gly Ile Asn Leu Leu Ser Asp Gly
1025                1030                1035                1040
Lys Thr Cys Ser Pro Gly Met Asn Ser Phe Leu Ile Phe Ala Arg Arg
                1045                1050                1055    
Ile Asp Ile Arg Met Val Ser Leu Asp Ile Pro Tyr Phe Ala Asp Val
            1060                1065                1070        
Val Val Pro Ile Asn Ile Thr Met Lys Asn Thr Ile Ala Ile Gly Val
        1075                1080                1085            
Asp Pro Gln Glu Gly Lys Val Tyr Trp Ser Asp Ser Thr Leu His Arg
    1090                1095                1100                
Ile Ser Arg Ala Asn Leu Asp Gly Ser Gln His Glu Asp Ile Ile Thr
1105                1110                1115                1120
Thr Gly Leu Gln Thr Thr Asp Gly Leu Ala Val Asp Ala Ile Gly Arg
                1125                1130                1135    
Lys Val Tyr Trp Thr Asp Thr Gly Thr Asn Arg Ile Glu Val Gly Asn
            1140                1145                1150        
Leu Asp Gly Ser Met Arg Lys Val Leu Val Trp Gln Asn Leu Asp Ser
        1155                1160                1165            
Pro Arg Ala Ile Val Leu Tyr His Glu Met Gly Phe Met Tyr Trp Thr
    1170                1175                1180                
Asp Trp Gly Glu Asn Ala Lys Leu Glu Arg Ser Gly Met Asp Gly Ser
1185                1190                1195                1200
Asp Arg Ala Val Leu Ile Asn Asn Asn Leu Gly Trp Pro Asn Gly Leu
                1205                1210                1215    
Thr Val Asp Lys Ala Ser Ser Gln Leu Leu Trp Ala Asp Ala His Thr
            1220                1225                1230        
Glu Arg Ile Glu Ala Ala Asp Leu Asn Gly Ala Asn Arg His Thr Leu
        1235                1240                1245            
Val Ser Pro Val Gln His Pro Tyr Gly Leu Thr Leu Leu Asp Ser Tyr
    1250                1255                1260                
Ile Tyr Trp Thr Asp Trp Gln Thr Arg Ser Ile His Arg Ala Asp Lys
1265                1270                1275                1280
Gly Thr Gly Ser Asn Val Ile Leu Val Arg Ser Asn Leu Pro Gly Leu
                1285                1290                1295    
Met Asp Met Gln Ala Val Asp Arg Ala Gln Pro Leu Gly Phe Asn Lys
            1300                1305                1310        
Cys Gly Ser Arg Asn Gly Gly Cys Ser His Leu Cys Leu Pro Arg Pro
        1315                1320                1325            
Ser Gly Phe Ser Cys Ala Cys Pro Thr Gly Ile Gln Leu Lys Gly Asp
    1330                1335                1340                
Gly Lys Thr Cys Asp Pro Ser Pro Glu Thr Tyr Leu Leu Phe Ser Ser
1345                1350                1355                1360
Arg Gly Ser Ile Arg Arg Ile Ser Leu Asp Thr Ser Asp His Thr Asp
                1365                1370                1375    
Val His Val Pro Val Pro Glu Leu Asn Asn Val Ile Ser Leu Asp Tyr
            1380                1385                1390        
Asp Ser Val Asp Gly Lys Val Tyr Tyr Thr Asp Val Phe Leu Asp Val
        1395                1400                1405            
Ile Arg Arg Ala Asp Leu Asn Gly Ser Asn Met Glu Thr Val Ile Gly
    1410                1415                1420                
Arg Gly Leu Lys Thr Thr Asp Gly Leu Ala Val Asp Trp Val Ala Arg
1425                1430                1435                1440
Asn Leu Tyr Trp Thr Asp Thr Gly Arg Asn Thr Ile Glu Ala Ser Arg
                1445                1450                1455    
Leu Asp Gly Ser Cys Arg Lys Val Leu Ile Asn Asn Ser Leu Asp Glu
            1460                1465                1470        
Pro Arg Ala Ile Ala Val Phe Pro Arg Lys Gly Tyr Leu Phe Trp Thr
        1475                1480                1485            
Asp Trp Gly His Ile Ala Lys Ile Glu Arg Ala Asn Leu Asp Gly Ser
    1490                1495                1500                
Glu Arg Lys Val Leu Ile Asn Thr Asp Leu Gly Trp Pro Asn Gly Leu
1505                1510                1515                1520
Thr Leu Asp Tyr Asp Thr Arg Arg Ile Tyr Trp Val Asp Ala His Leu
                1525                1530                1535    
Asp Arg Ile Glu Ser Ala Asp Leu Asn Gly Lys Leu Arg Gln Val Leu
            1540                1545                1550        
Val Ser His Val Ser His Pro Phe Ala Leu Thr Gln Gln Asp Arg Trp
        1555                1560                1565            
Ile Tyr Trp Thr Asp Trp Gln Thr Lys Ser Ile Gln Arg Val Asp Lys
    1570                1575                1580                
Tyr Ser Gly Arg Asn Lys Glu Thr Val Leu Ala Asn Val Glu Gly Leu
1585                1590                1595                1600
Met Asp Ile Ile Val Val Ser Pro Gln Arg Gln Thr Gly Thr Asn Ala
                1605                1610                1615    
Cys Gly Val Asn Asn Gly Gly Cys Thr His Leu Cys Phe Ala Arg Ala
            1620                1625                1630        
Ser Asp Phe Val Cys Ala Cys Pro Asp Glu Pro Asp Ser Arg Pro Cys
        1635                1640                1645            
Ser Leu Val Pro Gly Leu Val Pro Pro Ala Pro Arg Ala Thr Gly Met
    1650                1655                1660                
Ser Glu Lys Ser Pro Val Leu Pro Asn Thr Pro Pro Thr Thr Leu Tyr
1665                1670                1675                1680
Ser Ser Thr Thr Arg Thr Arg Thr Ser Leu Glu Glu Val Glu Gly Arg
                1685                1690                1695    
Cys Ser Glu Arg Asp Ala Arg Leu Gly Leu Cys Ala Arg Ser Asn Asp
            1700                1705                1710        
Ala Val Pro Ala Ala Pro Gly Glu Gly Leu His Ile Ser Tyr Ala Ile
        1715                1720                1725            
Gly Gly Leu Leu Ser Ile Leu Leu Ile Leu Val Val Ile Ala Ala Leu
    1730                1735                1740                
Met Leu Tyr Arg His Lys Lys Ser Lys Phe Thr Asp Pro Gly Met Gly
1745                1750                1755                1760
Asn Leu Thr Tyr Ser Asn Pro Ser Tyr Arg Thr Ser Thr Gln Glu Val
                1765                1770                1775    
Lys Ile Glu Ala Ile Pro Lys Pro Ala Met Tyr Asn Gln Leu Cys Tyr
            1780                1785                1790        
Lys Lys Glu Gly Gly Pro Asp His Asn Tyr Thr Lys Glu Lys Ile Lys
        1795                1800                1805            
Ile Val Glu Gly Ile Cys Leu Leu Ser Gly Asp Asp Ala Glu Trp Asp
    1810                1815                1820                
Asp Leu Lys Gln Leu Arg Ser Ser Arg Gly Gly Leu Leu Arg Asp His
1825                1830                1835                1840
Val Cys Met Lys Thr Asp Thr Val Ser Ile Gln Ala Ser Ser Gly Ser
                1845                1850                1855    
Leu Asp Asp Thr Glu Thr Glu Gln Leu Leu Gln Glu Glu Gln Ser Glu
            1860                1865                1870        
Cys Ser Ser Val His Thr Ala Ala Thr Pro Glu Arg Arg Gly Ser Leu
        1875                1880                1885            
Pro Asp Thr Gly Trp Lys His Glu Arg Lys Leu Ser Ser Glu Ser Gln
    1890                1895                1900                
Val
1905


<210> 5
<211> 249
<212> PRT
<213> Artificial Sequence

<220> 
<223> single chain antibody (scFv) fragment

<400> 5
Met Ala Gln Val Gln Leu Gln Glu Ser Gly Gly Glu Met Lys Lys Pro
 1               5                  10                  15      
Gly Glu Ser Leu Lys Ile Ser Cys Lys Gly Tyr Gly Tyr Ser Phe Ala
            20                  25                  30          
Thr Ser Trp Ile Gly Trp Val Arg Gln Met Pro Gly Arg Gly Leu Glu
        35                  40                  45              
Trp Met Ala Ile Met Tyr Pro Gly Asn Ser Asp Thr Arg His Asn Pro
    50                  55                  60                  
Ser Phe Glu Asp Gln Val Thr Met Ser Ala Asp Thr Ser Ile Asn Thr
65                  70                  75                  80  
Ala Tyr Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr
                85                  90                  95      
Tyr Cys Ala Arg Ala Gly Val Ala Gly Gly Ala Phe Asp Leu Trp Gly
            100                 105                 110         
Lys Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Ala
    130                 135                 140                 
Ser Val Ser Gly Ser Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly
145                 150                 155                 160 
Thr Ser Ser Gly Val Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln
                165                 170                 175     
His Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser Asn Arg
            180                 185                 190         
Pro Ser Gly Val Pro Asp Arg Phe Ser Ala Ser Lys Ser Gly Asn Thr
        195                 200                 205             
Ala Ser Leu Thr Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr
    210                 215                 220                 
Phe Cys Ser Thr Tyr Ala Pro Pro Gly Ile Ile Met Phe Gly Gly Gly
225                 230                 235                 240 
Thr Lys Leu Thr Val Leu Gly Ala Ala
                245                 


<210> 6
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> single chain antibody (scFv) fragment

<400> 6
Met Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro
 1               5                  10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
            20                  25                  30          
Asp Tyr Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ser Tyr Ile Ser Ser Ser Gly Ser Thr Ile Tyr Tyr Ala Asp
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Trp Ser Gly Glu Asp Ala Phe Asp Ile Trp Gly Gln
            100                 105                 110         
Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr Gln Ser Pro Ser
    130                 135                 140                 
Thr Leu Ser Ala Ser Val Gly Asp Arg Val Ala Ile Thr Cys Arg Ala
145                 150                 155                 160 
Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                165                 170                 175     
Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
            180                 185                 190         
Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Ala Asp Phe Thr Leu
        195                 200                 205             
Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
    210                 215                 220                 
Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
225                 230                 235                 240 
Val Lys Arg Ala Ala
                245 


<210> 7
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> single chain antibody (scFv) fragment

<400> 7
Met Ala Glu Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro
 1               5                  10                  15      
Gly Gly Ser Leu Ser Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Arg
            20                  25                  30          
Thr Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ala Gly Ile Ser Phe Asp Gly Arg Ser Glu Tyr Tyr Ala Asp
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Arg Gly Ser Tyr Gly Met Asp Val Trp Gly Arg
            100                 105                 110         
Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
    130                 135                 140                 
Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
145                 150                 155                 160 
Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                165                 170                 175     
Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
            180                 185                 190         
Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
        195                 200                 205             
Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
    210                 215                 220                 
Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
225                 230                 235                 240 
Ile Leu Arg Ala Ala
                245 


<210> 8
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> single chain antibody (scFv) fragment

<400> 8
Met Ala Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Arg Pro
 1               5                  10                  15      
Gly Gly Ser Leu Ser Leu Ser Cys Ala Val Ser Gly Ile Thr Leu Arg
            20                  25                  30          
Thr Tyr Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ala Gly Ile Ser Phe Asp Gly Arg Ser Glu Tyr Tyr Ala Asp
    50                  55                  60                  
Ser Val Gln Gly Arg Phe Thr Ile Ser Arg Asp Ser Ser Lys Asn Thr
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Gly Ala His Tyr Gly Phe Asp Ile Trp Gly Gln Gly
            100                 105                 110         
Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Thr Gly Gly Gly Gly
        115                 120                 125             
Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Thr
    130                 135                 140                 
Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser
145                 150                 155                 160 
Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys
                165                 170                 175     
Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly Ala
            180                 185                 190         
Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr
        195                 200                 205             
Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
    210                 215                 220                 
Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Glu Leu Glu Ile
225                 230                 235                 240 
Lys Arg Ala Ala
                


<210> 9
<211> 245
<212> PRT
<213> Artificial Sequence

<220> 
<223> single chain antibody (scFv) fragment

<220> 
<221> misc_feature
<222> (208)...(208)
<223> Xaa is any amino acid  

<400> 9
Met Ala Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro
 1               5                  10                  15      
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
            20                  25                  30          
Ser His Asn Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Val Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp
    50                  55                  60                  
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser
65                  70                  75                  80  
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
                85                  90                  95      
Tyr Cys Ala Arg Asp Arg Gly Ser Thr Gly Met Asp Val Trp Gly Arg
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly
        115                 120                 125             
Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser
    130                 135                 140                 
Thr Leu Ser Ala Ser Ile Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
145                 150                 155                 160 
Ser Glu Gly Ile Tyr His Trp Leu Ala Trp Tyr Gln Gln Lys Pro Gly
                165                 170                 175     
Lys Ala Pro Lys Leu Leu Ile Tyr Lys Ala Ser Ser Leu Ala Ser Gly
            180                 185                 190         
Ala Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Xaa
        195                 200                 205             
Thr Ile Ser Ser Leu Gln Pro Asp Asp Phe Ala Thr Tyr Tyr Cys Gln
    210                 215                 220                 
Gln Tyr Ser Asn Tyr Pro Leu Thr Phe Gly Gly Gly Thr Lys Leu Glu
225                 230                 235                 240 
Ile Lys Arg Ala Ala
                245 


<210> 10
<211> 244
<212> PRT
<213> Artificial Sequence

<220> 
<223> single chain antibody (scFv) fragment

<400> 10
Met Ala Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro
 1               5                  10                  15      
Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Ser
            20                  25                  30          
Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu
        35                  40                  45              
Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser
    50                  55                  60                  
Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Ser Gln Phe
65                  70                  75                  80  
Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Arg Gly Arg Tyr Phe Asp Val Trp Gly Arg Gly Thr Met Val
            100                 105                 110         
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
        115                 120                 125             
Gly Gly Ser Ser Tyr Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ser
    130                 135                 140                 
Pro Gly Gln Ser Ile Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val
145                 150                 155                 160 
Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala
                165                 170                 175     
Pro Lys Leu Met Ile Tyr Glu Gly Ser Lys Arg Pro Ser Gly Val Ser
            180                 185                 190         
Asn Arg Phe Ser Gly Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Ile
        195                 200                 205             
Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr
    210                 215                 220                 
Thr Thr Arg Ser Thr Arg Val Phe Gly Gly Gly Thr Lys Leu Thr Val
225                 230                 235                 240 
Leu Gly Ala Ala
                

