                         SEQUENCE LISTING

<110>  Yale University
       Albright, Ronald
       Braddock, Demetrios
 
<120>  Compositions and Methods for Modulating Coagulation

<130>  047162-5115-00-WO.602056

<150>  US 61/559,461
<151>  2011-11-14

<150>  US 61/703,687
<151>  2012-09-20

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  453
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Leu Leu Val Ile Leu Leu Phe Ser Gly Leu Ile Thr Gly Phe 
1               5                   10                  15      


Arg Ser Asp Ser Ser Ser Ser Leu Pro Pro Lys Leu Leu Leu Val Ser 
            20                  25                  30          


Phe Asp Gly Phe Arg Ala Asp Tyr Leu Lys Asn Tyr Glu Phe Pro His 
        35                  40                  45              


Leu Gln Asn Phe Ile Lys Glu Gly Val Leu Val Glu His Val Lys Asn 
    50                  55                  60                  


Val Phe Ile Thr Lys Thr Phe Pro Asn His Tyr Ser Ile Val Thr Gly 
65                  70                  75                  80  


Leu Tyr Glu Glu Ser His Gly Ile Val Ala Asn Ser Met Tyr Asp Ala 
                85                  90                  95      


Val Thr Lys Lys His Phe Ser Asp Ser Asn Asp Lys Asp Pro Phe Trp 
            100                 105                 110         


Trp Asn Glu Ala Val Pro Ile Trp Val Thr Asn Gln Leu Gln Glu Asn 
        115                 120                 125             


Arg Ser Ser Ala Ala Ala Met Trp Pro Gly Thr Asp Val Pro Ile His 
    130                 135                 140                 


Asp Thr Ile Ser Ser Tyr Phe Met Asn Tyr Asn Ser Ser Val Ser Phe 
145                 150                 155                 160 


Glu Glu Arg Leu Asn Asn Ile Thr Met Trp Leu Asn Asn Ser Asn Pro 
                165                 170                 175     


Pro Val Thr Phe Ala Thr Leu Tyr Trp Glu Glu Pro Asp Ala Ser Gly 
            180                 185                 190         


His Lys Tyr Gly Pro Glu Asp Lys Glu Asn Met Ser Arg Val Leu Lys 
        195                 200                 205             


Lys Ile Asp Asp Leu Ile Gly Asp Leu Val Gln Arg Leu Lys Met Leu 
    210                 215                 220                 


Gly Leu Trp Glu Asn Leu Asn Val Ile Ile Thr Ser Asp His Gly Met 
225                 230                 235                 240 


Thr Gln Cys Ser Gln Asp Arg Leu Ile Asn Leu Asp Ser Cys Ile Asp 
                245                 250                 255     


His Ser Tyr Tyr Thr Leu Ile Asp Leu Ser Pro Val Ala Ala Ile Leu 
            260                 265                 270         


Pro Lys Ile Asn Arg Thr Glu Val Tyr Asn Lys Leu Lys Asn Cys Ser 
        275                 280                 285             


Pro His Met Asn Val Tyr Leu Lys Glu Asp Ile Pro Asn Arg Phe Tyr 
    290                 295                 300                 


Tyr Gln His Asn Asp Arg Ile Gln Pro Ile Ile Leu Val Ala Asp Glu 
305                 310                 315                 320 


Gly Trp Thr Ile Val Leu Asn Glu Ser Ser Gln Lys Leu Gly Asp His 
                325                 330                 335     


Gly Tyr Asp Asn Ser Leu Pro Ser Met His Pro Phe Leu Ala Ala His 
            340                 345                 350         


Gly Pro Ala Phe His Lys Gly Tyr Lys His Ser Thr Ile Asn Ile Val 
        355                 360                 365             


Asp Ile Tyr Pro Met Met Cys His Ile Leu Gly Leu Lys Pro His Pro 
    370                 375                 380                 


Asn Asn Gly Thr Phe Gly His Thr Lys Cys Leu Leu Val Asp Gln Trp 
385                 390                 395                 400 


Cys Ile Asn Leu Pro Glu Ala Ile Ala Ile Val Ile Gly Ser Leu Leu 
                405                 410                 415     


Val Leu Thr Met Leu Thr Cys Leu Ile Ile Ile Met Gln Asn Arg Leu 
            420                 425                 430         


Ser Val Pro Arg Pro Phe Ser Arg Leu Gln Leu Gln Glu Asp Asp Asp 
        435                 440                 445             


Asp Pro Leu Ile Gly 
    450             


<210>  2
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Arg Arg Ser Ser Phe Gln Ser Cys Gln Ile Ile Ser Leu Phe 
1               5                   10                  15      


Thr Phe Ala Val Gly Val Asn Ile Cys Leu Gly Phe Thr Ala His Arg 
            20                  25                  30          


Ile Lys Arg Ala Glu Gly Trp Glu Glu Gly Pro Pro Thr Val Leu Ser 
        35                  40                  45              


Asp Ser Pro Trp Thr Asn Ile Ser Gly Ser Cys Lys Gly Arg Cys Phe 
    50                  55                  60                  


Glu Leu Gln Glu Ala Gly Pro Pro Asp Cys Arg Cys Asp Asn Leu Cys 
65                  70                  75                  80  


Lys Ser Tyr Thr Ser Cys Cys His Asp Phe Asp Glu Leu Cys Leu Lys 
                85                  90                  95      


Thr Ala Arg Gly Trp Glu Cys Thr Lys Asp Arg Cys Gly Glu Val Arg 
            100                 105                 110         


Asn Glu Glu Asn Ala Cys His Cys Ser Glu Asp Cys Leu Ala Arg Gly 
        115                 120                 125             


Asp Cys Cys Thr Asn Tyr Gln Val Val Cys Lys Gly Glu Ser His Trp 
    130                 135                 140                 


Val Asp Asp Asp Cys Glu Glu Ile Lys Ala Ala Glu Cys Pro Ala Gly 
145                 150                 155                 160 


Phe Val Arg Pro Pro Leu Ile Ile Phe Ser Val Asp Gly Phe Arg Ala 
                165                 170                 175     


Ser Tyr Met Lys Lys Gly Ser Lys Val Met Pro Asn Ile Glu Lys Leu 
            180                 185                 190         


Arg Ser Cys Gly Thr His Ser Pro Tyr Met Arg Pro Val Tyr Pro Thr 
        195                 200                 205             


Lys Thr Phe Pro Asn Leu Tyr Thr Leu Ala Thr Gly Leu Tyr Pro Glu 
    210                 215                 220                 


Ser His Gly Ile Val Gly Asn Ser Met Tyr Asp Pro Val Phe Asp Ala 
225                 230                 235                 240 


Thr Phe His Leu Arg Gly Arg Glu Lys Phe Asn His Arg Trp Trp Gly 
                245                 250                 255     


Gly Gln Pro Leu Trp Ile Thr Ala Thr Lys Gln Gly Val Lys Ala Gly 
            260                 265                 270         


Thr Phe Phe Trp Ser Val Val Ile Pro His Glu Arg Arg Ile Leu Thr 
        275                 280                 285             


Ile Leu Gln Trp Leu Thr Leu Pro Asp His Glu Arg Pro Ser Val Tyr 
    290                 295                 300                 


Ala Phe Tyr Ser Glu Gln Pro Asp Phe Ser Gly His Lys Tyr Gly Pro 
305                 310                 315                 320 


Phe Gly Pro Glu Met Thr Asn Pro Leu Arg Glu Ile Asp Lys Ile Val 
                325                 330                 335     


Gly Gln Leu Met Asp Gly Leu Lys Gln Leu Lys Leu His Arg Cys Val 
            340                 345                 350         


Asn Val Ile Phe Val Gly Asp His Gly Met Glu Asp Val Thr Cys Asp 
        355                 360                 365             


Arg Thr Glu Phe Leu Ser Asn Tyr Leu Thr Asn Val Asp Asp Ile Thr 
    370                 375                 380                 


Leu Val Pro Gly Thr Leu Gly Arg Ile Arg Ser Lys Phe Ser Asn Asn 
385                 390                 395                 400 


Ala Lys Tyr Asp Pro Lys Ala Ile Ile Ala Asn Leu Thr Cys Lys Lys 
                405                 410                 415     


Pro Asp Gln His Phe Lys Pro Tyr Leu Lys Gln His Leu Pro Lys Arg 
            420                 425                 430         


Leu His Tyr Ala Asn Asn Arg Arg Ile Glu Asp Ile His Leu Leu Val 
        435                 440                 445             


Glu Arg Arg Trp His Val Ala Arg Lys Pro Leu Asp Val Tyr Lys Lys 
    450                 455                 460                 


Pro Ser Gly Lys Cys Phe Phe Gln Gly Asp His Gly Phe Asp Asn Lys 
465                 470                 475                 480 


Val Asn Ser Met Gln Thr Val Phe Val Gly Tyr Gly Pro Thr Phe Lys 
                485                 490                 495     


Tyr Lys Thr Lys Val Pro Pro Phe Glu Asn Ile Glu Leu Tyr Asn Val 
            500                 505                 510         


Met Cys Asp Leu Leu Gly Leu Lys Pro Ala Pro Asn Asn Gly Thr His 
        515                 520                 525             


Gly Ser Leu Asn His Leu Leu Arg Thr Asn Thr Phe Arg Pro Thr Met 
    530                 535                 540                 


Pro Glu Glu Val Thr Arg Pro Asn Tyr Pro Gly Ile Met Tyr Leu Gln 
545                 550                 555                 560 


Ser Asp Phe Asp Leu Gly Cys Thr Cys Asp Asp Lys Val Glu Pro Lys 
                565                 570                 575     


Asn Lys Leu Asp Glu Leu Asn Lys Arg Leu His Thr Lys Gly Ser Thr 
            580                 585                 590         


Glu Glu Arg His Leu Leu Tyr Gly Arg Pro Ala Val Leu Tyr Arg Thr 
        595                 600                 605             


Arg Tyr Asp Ile Leu Tyr His Thr Asp Phe Glu Ser Gly Tyr Ser Glu 
    610                 615                 620                 


Ile Phe Leu Met Pro Leu Trp Thr Ser Tyr Thr Val Ser Lys Gln Ala 
625                 630                 635                 640 


Glu Val Ser Ser Val Pro Asp His Leu Thr Ser Cys Val Arg Pro Asp 
                645                 650                 655     


Val Arg Val Ser Pro Ser Phe Ser Gln Asn Cys Leu Ala Tyr Lys Asn 
            660                 665                 670         


Asp Lys Gln Met Ser Tyr Gly Phe Leu Phe Pro Pro Tyr Leu Ser Ser 
        675                 680                 685             


Ser Pro Glu Ala Lys Tyr Asp Ala Phe Leu Val Thr Asn Met Val Pro 
    690                 695                 700                 


Met Tyr Pro Ala Phe Lys Arg Val Trp Asn Tyr Phe Gln Arg Val Leu 
705                 710                 715                 720 


Val Lys Lys Tyr Ala Ser Glu Arg Asn Gly Val Asn Val Ile Ser Gly 
                725                 730                 735     


Pro Ile Phe Asp Tyr Asp Tyr Asp Gly Leu His Asp Thr Glu Asp Lys 
            740                 745                 750         


Ile Lys Gln Tyr Val Glu Gly Ser Ser Ile Pro Val Pro Thr His Tyr 
        755                 760                 765             


Tyr Ser Ile Ile Thr Ser Cys Leu Asp Phe Thr Gln Pro Ala Asp Lys 
    770                 775                 780                 


Cys Asp Gly Pro Leu Ser Val Ser Ser Phe Ile Leu Pro His Arg Pro 
785                 790                 795                 800 


Asp Asn Glu Glu Ser Cys Asn Ser Ser Glu Asp Glu Ser Lys Trp Val 
                805                 810                 815     


Glu Glu Leu Met Lys Met His Thr Ala Arg Val Arg Asp Ile Glu His 
            820                 825                 830         


Leu Thr Ser Leu Asp Phe Phe Arg Lys Thr Ser Arg Ser Tyr Pro Glu 
        835                 840                 845             


Ile Leu Thr Leu Lys Thr Tyr Leu His Thr Tyr Glu Ser Glu Ile 
    850                 855                 860             


