                         SEQUENCE LISTING

<110>  Merck Sharp & Dohme Corp.
       Zha, Dongxing
 
<120>  Fc containing polypeptides having increased anti-inflammatory 
       properties and increased FcRn binding

<130>  23175

<150>  61/561,412
<151>  2011-11-18

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  1
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt ggctccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttgttgac gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat ga                         762


<210>  2
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  2

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Ala 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  3
<211>  763
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 region containing mutations

<400>  3
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt gtacccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttggtgac gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat gag                        763


<210>  4
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  4

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Tyr 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Gly Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  5
<211>  770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  5
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt gttgccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttaacgac gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat gaggccggcc                 770


<210>  6
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 region containing mutations

<400>  6

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Leu 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Asn Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  7
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  7
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt gttgccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttgctgac gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat ga                         762


<210>  8
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  8

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Leu 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Ala Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  9
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  9
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt ggttccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttggtgac gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat ga                         762


<210>  10
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  10

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Val 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Gly Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  11
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  11
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt ggctccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttgttgct gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat ga                         762


<210>  12
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 region containing mutations

<400>  12

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Ala 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  13
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  13
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt gtttccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttgccgct gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacagagt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat ga                         762


<210>  14
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  14

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Ala Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  15
<211>  762
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  15
atgagatttc cttcaatttt tactgctgtt ttattcgcag catcctccgc attagctgct       60

gaaccaaagt cttgtgacaa gacacacact tgtccaccat gtccagctcc agaattgttg      120

ggtggtccat ccgttttttt gtttccacca aagccaaagg acactttgta catcactaga      180

gaaccagagg ttacatgtgt tgttgttgct gtttctcacg aggacccaga ggttaagttc      240

aactggtacg ttgacggtgt tgaagttcac aacgctaaga ctaagccaag agaagagcag      300

tacaactcca cttacgctgt tgtttccgtt ttgactgttt tgcaccagga ttggttgaac      360

ggtaaagaat acaagtgtaa ggtttccaac aaggctttgc cagctccaat cgaaaagact      420

atctccaagg ctaagggtca accaagagag ccacaggttt acactttgcc accatccaga      480

gatgagttga ctaagaacca ggtttccttg acttgtttgg ttaagggatt ctacccatcc      540

gacattgctg ttgagtggga atctaacggt caaccagaga acaactacaa gactactcca      600

ccagttttgg attctgacgg ttccttcttc ttgtactcca agttgactgt tgacaagtcc      660

agatggcaac agggtaacgt tttctcctgt tccgttatgc atgaggcttt gaagtttcac      720

tacactcaaa agtccttgtc tttgtcccct ggtaagtaat ga                         762


<210>  16
<211>  252
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region comprising mutations

<400>  16

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Ala Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Ala Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250         


<210>  17
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain antibody sequence containing mutations in the Fc 
       region

<400>  17

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Ala Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
                245                 250                 255     


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Ala Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu Lys Phe His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Light chain antibody sequence containing mutations

<400>  18

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ala Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg Tyr Asn Arg Ala Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  19
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  19
gctgaaccaa agtcttgtga caagacacac acttgtccac catgtccagc tccagaattg       60

ttgggtggtc catccgtttt tttggctcca ccaaagccaa aggacacttt gtacatcact      120

agagaaccag aggttacatg tgttgttgct gacgtttctc acgaggaccc agaggttaag      180

ttcaactggt acgttgacgg tgttgaagtt cacaacgcta agactaagcc aagagaagag      240

cagtacaact ccacttacag agttgtttcc gttttgactg ttttgcacca ggattggttg      300

aacggtaaag aatacaagtg taaggtttcc aacaaggctt tgccagctcc aatcgaaaag      360

actatctcca aggctaaggg tcaaccaaga gagccacagg tttacacttt gccaccatcc      420

agagatgagt tgactaagaa ccaggtttcc ttgacttgtt tggttaaggg attctaccca      480

tccgacattg ctgttgagtg ggaatctaac ggtcaaccag agaacaacta caagactact      540

ccaccagttt tggattctga cggttccttc ttcttgtact ccaagttgac tgttgacaag      600

tccagatggc aacagggtaa cgttttctcc tgttccgtta tgcatgaggc tttgaagttt      660

cactacactc aaaagtcctt gtctttgtcc cctggtaag                             699


<210>  20
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  20

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Ala Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Ala Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  21
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  21
gctgaaccaa agtcttgtga caagacacac acttgtccac catgtccagc tccagaattg       60

ttgggtggtc catccgtttt tttgtttcca ccaaagccaa aggacacttt gtacatcact      120

agagaaccag aggttacatg tgttgttgtt gacgtttctc acgaggaccc agaggttaag      180

ttcaactggt acgttgacgg tgttgaagtt cacaacgcta agactaagcc aagagaagag      240

cagtacaact ccacttacag agttgtttcc gttttgactg ttttgcacca ggattggttg      300

aacggtaaag aatacaagtg taaggtttcc aacaaggctt tgccagctcc aatcgaaaag      360

actatctcca aggctaaggg tcaaccaaga gagccacagg tttacacttt gccaccatcc      420

agagatgagt tgactaagaa ccaggtttcc ttgacttgtt tggttaaggg attctaccca      480

tccgacattg ctgttgagtg ggaatctaac ggtcaaccag agaacaacta caagactact      540

ccaccagttt tggattctga cggttccttc ttcttgtact ccaagttgac tgttgacaag      600

tccagatggc aacagggtaa cgttttctcc tgttccgtta tgcatgaggc tttgaagttt      660

cactacactc aaaagtcctt gtctttgtcc cctggtaag                             699


<210>  22
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 region containing mutations

<400>  22

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Tyr Ile Thr Arg Glu Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu Lys Phe His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  23
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region comprising mutations

<400>  23
gctgaaccaa agtcttgtga caagacacac acttgtccac catgtccagc tccagaattg       60

ttgggtggtc catccgtttt tttggctcca ccaaagccaa aggacacttt gatgatctcc      120

agaactccag aggttacatg tgttgttgct gacgtttctc acgaggaccc agaggttaag      180

ttcaactggt acgttgacgg tgttgaagtt cacaacgcta agactaagcc aagagaagag      240

cagtacaact ccacttacag agttgtttcc gttttgactg ttttgcacca ggattggttg      300

aacggtaaag aatacaagtg taaggtttcc aacaaggctt tgccagctcc aatcgaaaag      360

actatctcca aggctaaggg tcaaccaaga gagccacagg tttacacttt gccaccatcc      420

agagatgagt tgactaagaa ccaggtttcc ttgacttgtt tggttaaggg attctaccca      480

tccgacattg ctgttgagtg ggaatctaac ggtcaaccag agaacaacta caagactact      540

ccaccagttt tggattctga cggttccttc ttcttgtact ccaagttgac tgttgacaag      600

tccagatggc aacagggtaa cgttttctcc tgttccgtta tgcatgaggc tttgcacaac      660

cactacactc aaaagtcctt gtctttgtcc cctggtaag                             699


<210>  24
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region containing mutations

<400>  24

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Ala Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Ala Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230             


<210>  25
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain antibody sequence containing mutations in the Fc 
       region

<400>  25

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Ala Pro Pro Lys Pro Lys Asp Thr Leu Met 
                245                 250                 255     


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Ala Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  26
<211>  451
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Heavy chain antibody sequence containing mutations in Fc region

<400>  26

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Trp Asn Ser Gly His Ile Asp Tyr Ala Asp Ser Val 
    50                  55                  60                  


Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
        115                 120                 125             


Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 
    130                 135                 140                 


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
145                 150                 155                 160 


Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 
            180                 185                 190         


Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 
        195                 200                 205             


Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220                 


Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
225                 230                 235                 240 


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Tyr 
                245                 250                 255     


Ile Thr Arg Glu Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
            260                 265                 270         


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
        275                 280                 285             


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
    290                 295                 300                 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
305                 310                 315                 320 


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
                325                 330                 335     


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
            340                 345                 350         


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
        355                 360                 365             


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
    370                 375                 380                 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
385                 390                 395                 400 


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
                405                 410                 415     


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
            420                 425                 430         


His Glu Ala Leu Lys Phe His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
        435                 440                 445             


Pro Gly Lys 
    450     


<210>  27
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region

<400>  27

Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
1               5                   10                  15      


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
            20                  25                  30          


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
        35                  40                  45              


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
    50                  55                  60                  


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
65                  70                  75                  80  


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
                85                  90                  95      


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
            100                 105                 110         


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
        115                 120                 125             


Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
    130                 135                 140                 


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
145                 150                 155                 160 


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
                165                 170                 175     


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
            180                 185                 190         


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
        195                 200                 205             


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    210                 215                 220         


<210>  28
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human IgG1 Fc region

<400>  28

Ala Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15      


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            20                  25                  30          


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    50                  55                  60                  


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
65                  70                  75                  80  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                85                  90                  95      


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            100                 105                 110         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        115                 120                 125             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    130                 135                 140                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
145                 150                 155                 160 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                165                 170                 175     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            180                 185                 190         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        195                 200                 205             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    210                 215                 220                 


Lys Ser Leu Ser Leu Ser Pro Gly 
225                 230         


