                         SEQUENCE LISTING

<110>  Bolton, Diane
       Custers, Jerome
       Roederer, Mario
       Radosevic, Katarina
 
<120>  HETEROLOGOUS PRIME-BOOST IMMUNIZATION USING MEASLES VIRUS-BASED 
       VACCINES

<130>  11-919-PCT

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  1533
<212>  DNA
<213>  Simian immunodeficiency virus


<220>
<221>  CDS
<222>  (1)..(1533)

<400>  1
atg ggc gtg aga aac tcc gtc ttg tca ggg aag aaa gca gat gaa tta         48
Met Gly Val Arg Asn Ser Val Leu Ser Gly Lys Lys Ala Asp Glu Leu           
1               5                   10                  15                

gaa aaa att agg cta cga ccc aac gga aag aaa aag tac atg ttg aag         96
Glu Lys Ile Arg Leu Arg Pro Asn Gly Lys Lys Lys Tyr Met Leu Lys           
            20                  25                  30                    

cat gta gta tgg gca gca aat gaa tta gat aga ttt gga tta gca gaa        144
His Val Val Trp Ala Ala Asn Glu Leu Asp Arg Phe Gly Leu Ala Glu           
        35                  40                  45                        

agc ctg ttg gag aac aaa gaa gga tgt caa aaa ata ctt tcg gtc tta        192
Ser Leu Leu Glu Asn Lys Glu Gly Cys Gln Lys Ile Leu Ser Val Leu           
    50                  55                  60                            

gct cca tta gtg cca aca ggc tca gaa aat tta aaa agc ctt tat aat        240
Ala Pro Leu Val Pro Thr Gly Ser Glu Asn Leu Lys Ser Leu Tyr Asn           
65                  70                  75                  80            

act gtc tgc gtc atc tgg tgc att cac gca gaa gag aaa gtg aaa cac        288
Thr Val Cys Val Ile Trp Cys Ile His Ala Glu Glu Lys Val Lys His           
                85                  90                  95                

act gag gaa gca aaa cag ata gtg cag aga cac cta gtg gtg gaa aca        336
Thr Glu Glu Ala Lys Gln Ile Val Gln Arg His Leu Val Val Glu Thr           
            100                 105                 110                   

gga aca aca gaa act atg cca aaa aca agt aga cca aca gca cca tct        384
Gly Thr Thr Glu Thr Met Pro Lys Thr Ser Arg Pro Thr Ala Pro Ser           
        115                 120                 125                       

agc ggc aga gga gga aat tac cca gta caa caa ata ggt ggt aac tat        432
Ser Gly Arg Gly Gly Asn Tyr Pro Val Gln Gln Ile Gly Gly Asn Tyr           
    130                 135                 140                           

gtc cac ctg cca tta agc ccg aga aca tta aat gcc tgg gta aaa ttg        480
Val His Leu Pro Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Leu           
145                 150                 155                 160           

ata gag gaa aag aaa ttt gga gca gaa gta gtg cca gga ttt cag gca        528
Ile Glu Glu Lys Lys Phe Gly Ala Glu Val Val Pro Gly Phe Gln Ala           
                165                 170                 175               

ctg tca gaa ggt tgc acc ccc tat gac att aat cag atg tta aat tgt        576
Leu Ser Glu Gly Cys Thr Pro Tyr Asp Ile Asn Gln Met Leu Asn Cys           
            180                 185                 190                   

gtg gga gac cat caa gcg gct atg cag att atc aga gat att ata aac        624
Val Gly Asp His Gln Ala Ala Met Gln Ile Ile Arg Asp Ile Ile Asn           
        195                 200                 205                       

gag gag gct gca gat tgg gac ttg cag cac cca caa cca gct cca caa        672
Glu Glu Ala Ala Asp Trp Asp Leu Gln His Pro Gln Pro Ala Pro Gln           
    210                 215                 220                           

caa gga caa ctt agg gag ccg tca gga tca gat att gca gga aca act        720
Gln Gly Gln Leu Arg Glu Pro Ser Gly Ser Asp Ile Ala Gly Thr Thr           
225                 230                 235                 240           

agt tca gta gat gaa caa atc cag tgg atg tac aga caa cag aac ccc        768
Ser Ser Val Asp Glu Gln Ile Gln Trp Met Tyr Arg Gln Gln Asn Pro           
                245                 250                 255               

ata cca gta ggc aac att tac agg aga tgg atc caa ctg ggg ttg caa        816
Ile Pro Val Gly Asn Ile Tyr Arg Arg Trp Ile Gln Leu Gly Leu Gln           
            260                 265                 270                   

aaa tgt gtc aga atg tat aac cca aca aac att cta gat gta aaa caa        864
Lys Cys Val Arg Met Tyr Asn Pro Thr Asn Ile Leu Asp Val Lys Gln           
        275                 280                 285                       

ggg cca aaa gag cca ttt cag agc tat gta gac agg ttc tac aaa agt        912
Gly Pro Lys Glu Pro Phe Gln Ser Tyr Val Asp Arg Phe Tyr Lys Ser           
    290                 295                 300                           

tta aga gca gaa cag aca gat gca gca gta aag aat tgg atg act caa        960
Leu Arg Ala Glu Gln Thr Asp Ala Ala Val Lys Asn Trp Met Thr Gln           
305                 310                 315                 320           

aca ctg ctg att caa aat gct aac cca gat tgc aag cta gtg ctg aag       1008
Thr Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Leu Val Leu Lys           
                325                 330                 335               

ggg ctg ggt gtg aat ccc acc cta gaa gaa atg ctg acg gct tgt caa       1056
Gly Leu Gly Val Asn Pro Thr Leu Glu Glu Met Leu Thr Ala Cys Gln           
            340                 345                 350                   

gga gta ggg ggg ccg gga cag aag gct aga tta atg gca gaa gcc ctg       1104
Gly Val Gly Gly Pro Gly Gln Lys Ala Arg Leu Met Ala Glu Ala Leu           
        355                 360                 365                       

aaa gag gcc ctc gca cca gtg cca atc cct ttt gca gca gcc caa cag       1152
Lys Glu Ala Leu Ala Pro Val Pro Ile Pro Phe Ala Ala Ala Gln Gln           
    370                 375                 380                           

agg gga cca aga aag cca att aag tgt tgg aat tgt ggg aaa gag gga       1200
Arg Gly Pro Arg Lys Pro Ile Lys Cys Trp Asn Cys Gly Lys Glu Gly           
385                 390                 395                 400           

cac tct gca agg caa tgc aga gcc cca aga aga cag gga tgc tgg aaa       1248
His Ser Ala Arg Gln Cys Arg Ala Pro Arg Arg Gln Gly Cys Trp Lys           
                405                 410                 415               

tgt gga aaa atg gac cat gtt atg gcc aaa tgc cca gac aga cag gcg       1296
Cys Gly Lys Met Asp His Val Met Ala Lys Cys Pro Asp Arg Gln Ala           
            420                 425                 430                   

ggt ttt tta ggc ctt ggt cca tgg gga aag aag ccc cgc aat ttc ccc       1344
Gly Phe Leu Gly Leu Gly Pro Trp Gly Lys Lys Pro Arg Asn Phe Pro           
        435                 440                 445                       

atg gct caa gtg cat cag ggg ctg atg cca act gct ccc cca gag gac       1392
Met Ala Gln Val His Gln Gly Leu Met Pro Thr Ala Pro Pro Glu Asp           
    450                 455                 460                           

cca gct gtg gat ctg cta aag aac tac atg cag ttg ggc aag cag cag       1440
Pro Ala Val Asp Leu Leu Lys Asn Tyr Met Gln Leu Gly Lys Gln Gln           
465                 470                 475                 480           

aga gaa aag cag aga gaa agc aga gag aag cct tac aag gag gtg aca       1488
Arg Glu Lys Gln Arg Glu Ser Arg Glu Lys Pro Tyr Lys Glu Val Thr           
                485                 490                 495               

gag gat ttg ctg cac ctc aat tct ctc ttt gga gga gac cag tag           1533
Glu Asp Leu Leu His Leu Asn Ser Leu Phe Gly Gly Asp Gln                   
            500                 505                 510                   


<210>  2
<211>  510
<212>  PRT
<213>  Simian immunodeficiency virus

<400>  2

Met Gly Val Arg Asn Ser Val Leu Ser Gly Lys Lys Ala Asp Glu Leu 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Asn Gly Lys Lys Lys Tyr Met Leu Lys 
            20                  25                  30          


His Val Val Trp Ala Ala Asn Glu Leu Asp Arg Phe Gly Leu Ala Glu 
        35                  40                  45              


Ser Leu Leu Glu Asn Lys Glu Gly Cys Gln Lys Ile Leu Ser Val Leu 
    50                  55                  60                  


Ala Pro Leu Val Pro Thr Gly Ser Glu Asn Leu Lys Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Cys Val Ile Trp Cys Ile His Ala Glu Glu Lys Val Lys His 
                85                  90                  95      


Thr Glu Glu Ala Lys Gln Ile Val Gln Arg His Leu Val Val Glu Thr 
            100                 105                 110         


Gly Thr Thr Glu Thr Met Pro Lys Thr Ser Arg Pro Thr Ala Pro Ser 
        115                 120                 125             


Ser Gly Arg Gly Gly Asn Tyr Pro Val Gln Gln Ile Gly Gly Asn Tyr 
    130                 135                 140                 


Val His Leu Pro Leu Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Leu 
145                 150                 155                 160 


Ile Glu Glu Lys Lys Phe Gly Ala Glu Val Val Pro Gly Phe Gln Ala 
                165                 170                 175     


Leu Ser Glu Gly Cys Thr Pro Tyr Asp Ile Asn Gln Met Leu Asn Cys 
            180                 185                 190         


Val Gly Asp His Gln Ala Ala Met Gln Ile Ile Arg Asp Ile Ile Asn 
        195                 200                 205             


Glu Glu Ala Ala Asp Trp Asp Leu Gln His Pro Gln Pro Ala Pro Gln 
    210                 215                 220                 


Gln Gly Gln Leu Arg Glu Pro Ser Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Ser Val Asp Glu Gln Ile Gln Trp Met Tyr Arg Gln Gln Asn Pro 
                245                 250                 255     


Ile Pro Val Gly Asn Ile Tyr Arg Arg Trp Ile Gln Leu Gly Leu Gln 
            260                 265                 270         


Lys Cys Val Arg Met Tyr Asn Pro Thr Asn Ile Leu Asp Val Lys Gln 
        275                 280                 285             


Gly Pro Lys Glu Pro Phe Gln Ser Tyr Val Asp Arg Phe Tyr Lys Ser 
    290                 295                 300                 


Leu Arg Ala Glu Gln Thr Asp Ala Ala Val Lys Asn Trp Met Thr Gln 
305                 310                 315                 320 


Thr Leu Leu Ile Gln Asn Ala Asn Pro Asp Cys Lys Leu Val Leu Lys 
                325                 330                 335     


Gly Leu Gly Val Asn Pro Thr Leu Glu Glu Met Leu Thr Ala Cys Gln 
            340                 345                 350         


Gly Val Gly Gly Pro Gly Gln Lys Ala Arg Leu Met Ala Glu Ala Leu 
        355                 360                 365             


Lys Glu Ala Leu Ala Pro Val Pro Ile Pro Phe Ala Ala Ala Gln Gln 
    370                 375                 380                 


Arg Gly Pro Arg Lys Pro Ile Lys Cys Trp Asn Cys Gly Lys Glu Gly 
385                 390                 395                 400 


His Ser Ala Arg Gln Cys Arg Ala Pro Arg Arg Gln Gly Cys Trp Lys 
                405                 410                 415     


Cys Gly Lys Met Asp His Val Met Ala Lys Cys Pro Asp Arg Gln Ala 
            420                 425                 430         


Gly Phe Leu Gly Leu Gly Pro Trp Gly Lys Lys Pro Arg Asn Phe Pro 
        435                 440                 445             


Met Ala Gln Val His Gln Gly Leu Met Pro Thr Ala Pro Pro Glu Asp 
    450                 455                 460                 


Pro Ala Val Asp Leu Leu Lys Asn Tyr Met Gln Leu Gly Lys Gln Gln 
465                 470                 475                 480 


Arg Glu Lys Gln Arg Glu Ser Arg Glu Lys Pro Tyr Lys Glu Val Thr 
                485                 490                 495     


Glu Asp Leu Leu His Leu Asn Ser Leu Phe Gly Gly Asp Gln 
            500                 505                 510 


<210>  3
<211>  1539
<212>  DNA
<213>  Human immunodeficiency virus


<220>
<221>  CDS
<222>  (1)..(1539)

<400>  3
atg ggc gcc agg gcc agc gtg ctg agc ggc ggc gag ctg gac agg tgg         48
Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp           
1               5                   10                  15                

gag aag atc agg ctg agg ccc ggc ggc aag aag aag tat aag ctg aag         96
Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys           
            20                  25                  30                    

cac atc gtg tgg gcc agc agg gag ctg gag agg ttc gcc gtg aac ccc        144
His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro           
        35                  40                  45                        

ggc ctg ctg gag acc agc gag ggc tgc agg cag atc ctg ggc cag ctg        192
Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu           
    50                  55                  60                            

cag ccc agc ctg cag acc ggc agc gag gag ctg agg agc ctg tac aac        240
Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn           
65                  70                  75                  80            

acc gtg gcc acc ctg tac tgc gtg cac cag agg atc gag atc aag gac        288
Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp           
                85                  90                  95                

acc aag gag gcc ctg gac aag atc gag gag gag cag aac aag tcc aag        336
Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys           
            100                 105                 110                   

aag aag gcc cag cag gcc gcc gcc gac acc ggc cac agc agc cag gtg        384
Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Ser Gln Val           
        115                 120                 125                       

agc cag aac tac ccc atc gtg cag aac atc cag ggc cag atg gtg cac        432
Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His           
    130                 135                 140                           

cag gcc atc agc ccc agg acc ctg aac gcc tgg gtg aag gtg gtg gag        480
Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu           
145                 150                 155                 160           

gag aag gcc ttc agc ccc gag gtg atc ccc atg ttc agc gcc ctg agc        528
Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser           
                165                 170                 175               

gag gga gcc acc ccc cag gac ctg aac acc atg ctg aac acc gtg ggc        576
Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly           
            180                 185                 190                   

ggc cac cag gcc gcc atg cag atg ctg aag gag acc atc aac gag gag        624
Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu           
        195                 200                 205                       

gcc gcc gag tgg gac agg gtg cac ccc gtg cac gcc ggc ccc atc gcc        672
Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala           
    210                 215                 220                           

ccc ggc cag atg agg gag ccc cgc ggc agc gac atc gcc ggc acc acc        720
Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr           
225                 230                 235                 240           

agc acc ctg cag gag cag atc ggc tgg atg acc aac aac ccc ccc atc        768
Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile           
                245                 250                 255               

ccc gtg ggc gaa atc tac aag agg tgg atc atc ctg ggc ctg aac aag        816
Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys           
            260                 265                 270                   

atc gtg agg atg tac agc ccc acc agc atc ctg gat atc agg cag ggc        864
Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly           
        275                 280                 285                       

ccc aaa gag ccc ttc agg gac tac gtg gac agg ttc tac aag acc ctg        912
Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu           
    290                 295                 300                           

cgc gcc gag cag gcc agc cag gag gtg aag aac tgg atg acc gag acc        960
Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr           
305                 310                 315                 320           

ctg ctg gtg cag aac gcc aac ccc gac tgc aag acc atc ctg aag gcc       1008
Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala           
                325                 330                 335               

ctg gga ccc gcc gcc acc ctg gag gag atg atg acc gcc tgc cag ggc       1056
Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly           
            340                 345                 350                   

gtg ggc ggc ccc ggc cac aag gcc agg gtg ctg gcc gag gcc atg agc       1104
Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser           
        355                 360                 365                       

cag gtg acc aac acc gcc acc atc atg atg cag agg ggc aac ttc agg       1152
Gln Val Thr Asn Thr Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg           
    370                 375                 380                           

aac cag agg aag atg gtg aag tgc ttc aac tgc ggc aag gag ggc cac       1200
Asn Gln Arg Lys Met Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His           
385                 390                 395                 400           

acc gcc agg aac tgc cgc gcc ccc agg aag aag ggc tgc tgg aag tgc       1248
Thr Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys           
                405                 410                 415               

ggc aag gag ggc cac cag atg aag gac tgc acc gag agg cag gcc aac       1296
Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn           
            420                 425                 430                   

ttc ctg ggc aag atc tgg ccc agc tac aag ggc agg ccc ggc aac ttc       1344
Phe Leu Gly Lys Ile Trp Pro Ser Tyr Lys Gly Arg Pro Gly Asn Phe           
        435                 440                 445                       

ctg cag agc agg ccc gag ccc acc gcc ccc ccc ttc ctg cag agc agg       1392
Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Phe Leu Gln Ser Arg           
    450                 455                 460                           

ccc gag ccc acc gcc ccc ccc gag gag agc ttc agg agc ggc gtg gag       1440
Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg Ser Gly Val Glu           
465                 470                 475                 480           

acc acc acc cct cct cag aag cag gag ccc atc gac aag gag ctg tac       1488
Thr Thr Thr Pro Pro Gln Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr           
                485                 490                 495               

ccc ctg acc agc ctg agg agc ctg ttc ggc aac gac ccc agc agc cag       1536
Pro Leu Thr Ser Leu Arg Ser Leu Phe Gly Asn Asp Pro Ser Ser Gln           
            500                 505                 510                   

tga                                                                   1539


<210>  4
<211>  512
<212>  PRT
<213>  Human immunodeficiency virus

<400>  4

Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Arg Trp 
1               5                   10                  15      


Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
            20                  25                  30          


His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 
        35                  40                  45              


Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 
    50                  55                  60                  


Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 
65                  70                  75                  80  


Thr Val Ala Thr Leu Tyr Cys Val His Gln Arg Ile Glu Ile Lys Asp 
                85                  90                  95      


Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys 
            100                 105                 110         


Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly His Ser Ser Gln Val 
        115                 120                 125             


Ser Gln Asn Tyr Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His 
    130                 135                 140                 


Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 
145                 150                 155                 160 


Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 
                165                 170                 175     


Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 
            180                 185                 190         


Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 
        195                 200                 205             


Ala Ala Glu Trp Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala 
    210                 215                 220                 


Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr 
225                 230                 235                 240 


Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile 
                245                 250                 255     


Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 
            260                 265                 270         


Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 
        275                 280                 285             


Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 
    290                 295                 300                 


Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 
305                 310                 315                 320 


Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 
                325                 330                 335     


Leu Gly Pro Ala Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly 
            340                 345                 350         


Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 
        355                 360                 365             


Gln Val Thr Asn Thr Ala Thr Ile Met Met Gln Arg Gly Asn Phe Arg 
    370                 375                 380                 


Asn Gln Arg Lys Met Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 
385                 390                 395                 400 


Thr Ala Arg Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys Trp Lys Cys 
                405                 410                 415     


Gly Lys Glu Gly His Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 
            420                 425                 430         


Phe Leu Gly Lys Ile Trp Pro Ser Tyr Lys Gly Arg Pro Gly Asn Phe 
        435                 440                 445             


Leu Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Phe Leu Gln Ser Arg 
    450                 455                 460                 


Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg Ser Gly Val Glu 
465                 470                 475                 480 


Thr Thr Thr Pro Pro Gln Lys Gln Glu Pro Ile Asp Lys Glu Leu Tyr 
                485                 490                 495     


Pro Leu Thr Ser Leu Arg Ser Leu Phe Gly Asn Asp Pro Ser Ser Gln 
            500                 505                 510         


