                         SEQUENCE LISTING

<110>  EMORY UNIVERSITY
       CHILDREN'S HEALTHCARE OF ATLANTA, INC.
       GALIPEAU, Jacques
       HSIEH, Hsiang-Chuan
 
<120>  CONJUGATES OF GM-CSF AND IL-7, COMPOSITIONS AND METHODS RELATED 
       THERETO

<130>  11172-PCT

<150>  61/559,355
<151>  2011-11-14

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  290
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Trp Leu Gln Asn Leu Leu Phe Leu Gly Ile Val Val Tyr Ser Leu 
1               5                   10                  15      


Ser Ala Pro Thr Arg Ser Pro Ile Thr Val Thr Arg Pro Trp Lys His 
            20                  25                  30          


Val Glu Ala Ile Lys Glu Ala Leu Asn Leu Leu Asp Asp Met Pro Val 
        35                  40                  45              


Thr Leu Asn Glu Glu Val Glu Val Val Ser Asn Glu Phe Ser Phe Lys 
    50                  55                  60                  


Lys Leu Thr Cys Val Gln Thr Arg Leu Lys Ile Phe Glu Gln Gly Leu 
65                  70                  75                  80  


Arg Gly Asn Phe Thr Lys Leu Lys Gly Ala Leu Asn Met Thr Ala Ser 
                85                  90                  95      


Tyr Tyr Gln Thr Tyr Cys Pro Pro Thr Pro Glu Thr Asp Cys Glu Thr 
            100                 105                 110         


Gln Val Thr Thr Tyr Ala Asp Phe Ile Asp Ser Leu Lys Thr Phe Leu 
        115                 120                 125             


Thr Ser Pro Val Gly Gly Ala Asn Met Phe His Val Ser Phe Arg Tyr 
    130                 135                 140                 


Ile Phe Gly Ile Pro Pro Leu Leu Leu Val Leu Leu Pro Val Thr Ser 
145                 150                 155                 160 


Ser Glu Cys His Ile Lys Asp Lys Glu Gly Lys Ala Tyr Glu Ser Val 
                165                 170                 175     


Leu Met Ile Ser Ile Asp Glu Leu Asp Lys Met Thr Gly Thr Asp Ser 
            180                 185                 190         


Asn Cys Pro Asn Asn Glu Pro Asn Phe Phe Arg Lys His Val Cys Asp 
        195                 200                 205             


Asp Thr Lys Glu Ala Ala Phe Leu Asn Arg Ala Ala Arg Lys Leu Lys 
    210                 215                 220                 


Gln Phe Leu Lys Met Asn Ile Ser Glu Glu Phe Asn Val His Leu Leu 
225                 230                 235                 240 


Thr Val Ser Gln Gly Thr Gln Thr Leu Val Asn Cys Thr Ser Lys Glu 
                245                 250                 255     


Glu Lys Asn Val Lys Glu Gln Lys Lys Asn Asp Ala Cys Phe Leu Lys 
            260                 265                 270         


Arg Leu Leu Arg Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Lys Gly 
        275                 280                 285             


Ser Ile 
    290 


<210>  2
<211>  325
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Trp Leu Gln Ser Leu Leu Leu Leu Gly Thr Val Ala Cys Ser Ile 
1               5                   10                  15      


Ser Ala Pro Ala Arg Ser Pro Ser Pro Ser Thr Gln Pro Trp Glu His 
            20                  25                  30          


Val Asn Ala Ile Gln Glu Ala Arg Arg Leu Leu Asn Leu Ser Arg Asp 
        35                  40                  45              


Thr Ala Ala Glu Met Asn Glu Thr Val Glu Val Ile Ser Glu Met Phe 
    50                  55                  60                  


Asp Leu Gln Glu Pro Thr Cys Leu Gln Thr Arg Leu Glu Leu Tyr Lys 
65                  70                  75                  80  


Gln Gly Leu Arg Gly Ser Leu Thr Lys Leu Lys Gly Pro Leu Thr Met 
                85                  90                  95      


Met Ala Ser His Tyr Lys Gln His Cys Pro Pro Thr Pro Glu Thr Ser 
            100                 105                 110         


Cys Ala Thr Gln Ile Ile Thr Phe Glu Ser Phe Lys Glu Asn Leu Lys 
        115                 120                 125             


Asp Phe Leu Leu Val Ile Pro Phe Asp Cys Trp Glu Pro Val Gln Glu 
    130                 135                 140                 


Ser Pro Val Asn Met Phe His Val Ser Phe Arg Tyr Ile Phe Gly Leu 
145                 150                 155                 160 


Pro Pro Leu Ile Leu Val Leu Leu Pro Val Ala Ser Ser Asp Cys Asp 
                165                 170                 175     


Ile Glu Gly Lys Asp Gly Lys Gln Tyr Glu Ser Val Leu Met Val Ser 
            180                 185                 190         


Ile Asp Gln Leu Leu Asp Ser Met Lys Glu Ile Gly Ser Asn Cys Leu 
        195                 200                 205             


Asn Asn Glu Phe Asn Phe Phe Lys Arg His Ile Cys Asp Ala Asn Lys 
    210                 215                 220                 


Glu Gly Met Phe Leu Phe Arg Ala Ala Arg Lys Leu Arg Gln Phe Leu 
225                 230                 235                 240 


Lys Met Asn Ser Thr Gly Asp Phe Asp Leu His Leu Leu Lys Val Ser 
                245                 250                 255     


Glu Gly Thr Thr Ile Leu Leu Asn Cys Thr Gly Gln Val Lys Gly Arg 
            260                 265                 270         


Lys Pro Ala Ala Leu Gly Glu Ala Gln Pro Thr Lys Ser Leu Glu Glu 
        275                 280                 285             


Asn Lys Ser Leu Lys Glu Gln Lys Lys Leu Asn Asp Leu Cys Phe Leu 
    290                 295                 300                 


Lys Arg Leu Leu Gln Glu Ile Lys Thr Cys Trp Asn Lys Ile Leu Met 
305                 310                 315                 320 


Gly Thr Lys Glu His 
                325 


<210>  3
<211>  978
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Thr Gly Thr Gly Gly Cys Thr Gly Cys Ala Gly Ala Gly Cys Cys 
1               5                   10                  15      


Thr Gly Cys Thr Gly Cys Thr Cys Thr Thr Gly Gly Gly Cys Ala Cys 
            20                  25                  30          


Thr Gly Thr Gly Gly Cys Cys Thr Gly Cys Ala Gly Cys Ala Thr Cys 
        35                  40                  45              


Thr Cys Thr Gly Cys Ala Cys Cys Cys Gly Cys Cys Cys Gly Cys Thr 
    50                  55                  60                  


Cys Gly Cys Cys Cys Ala Gly Cys Cys Cys Cys Ala Gly Cys Ala Cys 
65                  70                  75                  80  


Gly Cys Ala Gly Cys Cys Cys Thr Gly Gly Gly Ala Gly Cys Ala Thr 
                85                  90                  95      


Gly Thr Gly Ala Ala Thr Gly Cys Cys Ala Thr Cys Cys Ala Gly Gly 
            100                 105                 110         


Ala Gly Gly Cys Cys Cys Gly Gly Cys Gly Thr Cys Thr Cys Cys Thr 
        115                 120                 125             


Gly Ala Ala Cys Cys Thr Gly Ala Gly Thr Ala Gly Ala Gly Ala Cys 
    130                 135                 140                 


Ala Cys Thr Gly Cys Thr Gly Cys Thr Gly Ala Gly Ala Thr Gly Ala 
145                 150                 155                 160 


Ala Thr Gly Ala Ala Ala Cys Ala Gly Thr Ala Gly Ala Ala Gly Thr 
                165                 170                 175     


Cys Ala Thr Cys Thr Cys Ala Gly Ala Ala Ala Thr Gly Thr Thr Thr 
            180                 185                 190         


Gly Ala Cys Cys Thr Cys Cys Ala Gly Gly Ala Gly Cys Cys Gly Ala 
        195                 200                 205             


Cys Cys Thr Gly Cys Cys Thr Ala Cys Ala Gly Ala Cys Cys Cys Gly 
    210                 215                 220                 


Cys Cys Thr Gly Gly Ala Gly Cys Thr Gly Thr Ala Cys Ala Ala Gly 
225                 230                 235                 240 


Cys Ala Gly Gly Gly Cys Cys Thr Gly Cys Gly Gly Gly Gly Cys Ala 
                245                 250                 255     


Gly Cys Cys Thr Cys Ala Cys Cys Ala Ala Gly Cys Thr Cys Ala Ala 
            260                 265                 270         


Gly Gly Gly Cys Cys Cys Cys Thr Thr Gly Ala Cys Cys Ala Thr Gly 
        275                 280                 285             


Ala Thr Gly Gly Cys Cys Ala Gly Cys Cys Ala Cys Thr Ala Cys Ala 
    290                 295                 300                 


Ala Gly Cys Ala Gly Cys Ala Cys Thr Gly Cys Cys Cys Thr Cys Cys 
305                 310                 315                 320 


Ala Ala Cys Cys Cys Cys Gly Gly Ala Ala Ala Cys Thr Thr Cys Cys 
                325                 330                 335     


Thr Gly Thr Gly Cys Ala Ala Cys Cys Cys Ala Gly Ala Thr Thr Ala 
            340                 345                 350         


Thr Cys Ala Cys Cys Thr Thr Thr Gly Ala Ala Ala Gly Thr Thr Thr 
        355                 360                 365             


Cys Ala Ala Ala Gly Ala Gly Ala Ala Cys Cys Thr Gly Ala Ala Gly 
    370                 375                 380                 


Gly Ala Cys Thr Thr Thr Cys Thr Gly Cys Thr Thr Gly Thr Cys Ala 
385                 390                 395                 400 


Thr Cys Cys Cys Cys Thr Thr Thr Gly Ala Cys Thr Gly Cys Thr Gly 
                405                 410                 415     


Gly Gly Ala Gly Cys Cys Ala Gly Thr Cys Cys Ala Gly Gly Ala Gly 
            420                 425                 430         


Thr Cys Ala Cys Cys Gly Gly Thr Cys Ala Ala Cys Ala Thr Gly Thr 
        435                 440                 445             


Thr Cys Cys Ala Thr Gly Thr Thr Thr Cys Thr Thr Thr Thr Ala Gly 
    450                 455                 460                 


Gly Thr Ala Thr Ala Thr Cys Thr Thr Thr Gly Gly Ala Cys Thr Thr 
465                 470                 475                 480 


Cys Cys Thr Cys Cys Cys Cys Thr Gly Ala Thr Cys Cys Thr Thr Gly 
                485                 490                 495     


Thr Thr Cys Thr Gly Thr Thr Gly Cys Cys Ala Gly Thr Ala Gly Cys 
            500                 505                 510         


Ala Thr Cys Ala Thr Cys Thr Gly Ala Thr Thr Gly Thr Gly Ala Thr 
        515                 520                 525             


Ala Thr Thr Gly Ala Ala Gly Gly Thr Ala Ala Ala Gly Ala Thr Gly 
    530                 535                 540                 


Gly Cys Ala Ala Ala Cys Ala Ala Thr Ala Thr Gly Ala Gly Ala Gly 
545                 550                 555                 560 


Thr Gly Thr Thr Cys Thr Ala Ala Thr Gly Gly Thr Cys Ala Gly Cys 
                565                 570                 575     


Ala Thr Cys Gly Ala Thr Cys Ala Ala Thr Thr Ala Thr Thr Gly Gly 
            580                 585                 590         


Ala Cys Ala Gly Cys Ala Thr Gly Ala Ala Ala Gly Ala Ala Ala Thr 
        595                 600                 605             


Thr Gly Gly Thr Ala Gly Cys Ala Ala Thr Thr Gly Cys Cys Thr Gly 
    610                 615                 620                 


Ala Ala Thr Ala Ala Thr Gly Ala Ala Thr Thr Thr Ala Ala Cys Thr 
625                 630                 635                 640 


Thr Thr Thr Thr Thr Ala Ala Ala Ala Gly Ala Cys Ala Thr Ala Thr 
                645                 650                 655     


Cys Thr Gly Thr Gly Ala Thr Gly Cys Thr Ala Ala Thr Ala Ala Gly 
            660                 665                 670         


Gly Ala Ala Gly Gly Thr Ala Thr Gly Thr Thr Thr Thr Thr Ala Thr 
        675                 680                 685             


Thr Cys Cys Gly Thr Gly Cys Thr Gly Cys Thr Cys Gly Cys Ala Ala 
    690                 695                 700                 


Gly Thr Thr Gly Ala Gly Gly Cys Ala Ala Thr Thr Thr Cys Thr Thr 
705                 710                 715                 720 


Ala Ala Ala Ala Thr Gly Ala Ala Thr Ala Gly Cys Ala Cys Thr Gly 
                725                 730                 735     


Gly Thr Gly Ala Thr Thr Thr Thr Gly Ala Thr Cys Thr Cys Cys Ala 
            740                 745                 750         


Cys Thr Thr Ala Thr Thr Ala Ala Ala Ala Gly Thr Thr Thr Cys Ala 
        755                 760                 765             


Gly Ala Ala Gly Gly Cys Ala Cys Ala Ala Cys Ala Ala Thr Ala Cys 
    770                 775                 780                 


Thr Gly Thr Thr Gly Ala Ala Cys Thr Gly Cys Ala Cys Thr Gly Gly 
785                 790                 795                 800 


Cys Cys Ala Gly Gly Thr Thr Ala Ala Ala Gly Gly Ala Ala Gly Ala 
                805                 810                 815     


Ala Ala Ala Cys Cys Ala Gly Cys Thr Gly Cys Cys Cys Thr Gly Gly 
            820                 825                 830         


Gly Thr Gly Ala Ala Gly Cys Cys Cys Ala Ala Cys Cys Ala Ala Cys 
        835                 840                 845             


Ala Ala Ala Gly Ala Gly Thr Thr Thr Gly Gly Ala Ala Gly Ala Ala 
    850                 855                 860                 


Ala Ala Thr Ala Ala Ala Thr Cys Thr Thr Thr Ala Ala Ala Gly Gly 
865                 870                 875                 880 


Ala Ala Cys Ala Gly Ala Ala Ala Ala Ala Ala Cys Thr Gly Ala Ala 
                885                 890                 895     


Thr Gly Ala Cys Thr Thr Gly Thr Gly Thr Thr Thr Cys Cys Thr Ala 
            900                 905                 910         


Ala Ala Gly Ala Gly Ala Cys Thr Ala Thr Thr Ala Cys Ala Ala Gly 
        915                 920                 925             


Ala Gly Ala Thr Ala Ala Ala Ala Ala Cys Thr Thr Gly Thr Thr Gly 
    930                 935                 940                 


Gly Ala Ala Thr Ala Ala Ala Ala Thr Thr Thr Thr Gly Ala Thr Gly 
945                 950                 955                 960 


Gly Gly Cys Ala Cys Thr Ala Ala Ala Gly Ala Ala Cys Ala Cys Thr 
                965                 970                 975     


Gly Ala 
        


<210>  4
<211>  873
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Thr Gly Thr Gly Gly Cys Thr Gly Cys Ala Gly Ala Ala Thr Thr 
1               5                   10                  15      


Thr Ala Cys Thr Thr Thr Thr Cys Cys Thr Gly Gly Gly Cys Ala Thr 
            20                  25                  30          


Thr Gly Thr Gly Gly Thr Cys Thr Ala Cys Ala Gly Cys Cys Thr Cys 
        35                  40                  45              


Thr Cys Ala Gly Cys Ala Cys Cys Cys Ala Cys Cys Cys Gly Cys Thr 
    50                  55                  60                  


Cys Ala Cys Cys Cys Ala Thr Cys Ala Cys Thr Gly Thr Cys Ala Cys 
65                  70                  75                  80  


Cys Cys Gly Gly Cys Cys Thr Thr Gly Gly Ala Ala Gly Cys Ala Thr 
                85                  90                  95      


Gly Thr Ala Gly Ala Gly Gly Cys Cys Ala Thr Cys Ala Ala Ala Gly 
            100                 105                 110         


Ala Ala Gly Cys Cys Cys Thr Gly Ala Ala Cys Cys Thr Cys Cys Thr 
        115                 120                 125             


Gly Gly Ala Thr Gly Ala Cys Ala Thr Gly Cys Cys Thr Gly Thr Cys 
    130                 135                 140                 


Ala Cys Gly Thr Thr Gly Ala Ala Thr Gly Ala Ala Gly Ala Gly Gly 
145                 150                 155                 160 


Thr Ala Gly Ala Ala Gly Thr Cys Gly Thr Cys Thr Cys Thr Ala Ala 
                165                 170                 175     


Cys Gly Ala Gly Thr Thr Cys Thr Cys Cys Thr Thr Cys Ala Ala Gly 
            180                 185                 190         


Ala Ala Gly Cys Thr Ala Ala Cys Ala Thr Gly Thr Gly Thr Gly Cys 
        195                 200                 205             


Ala Gly Ala Cys Cys Cys Gly Cys Cys Thr Gly Ala Ala Gly Ala Thr 
    210                 215                 220                 


Ala Thr Thr Cys Gly Ala Gly Cys Ala Gly Gly Gly Thr Cys Thr Ala 
225                 230                 235                 240 


Cys Gly Gly Gly Gly Cys Ala Ala Thr Thr Thr Cys Ala Cys Cys Ala 
                245                 250                 255     


Ala Ala Cys Thr Cys Ala Ala Gly Gly Gly Cys Gly Cys Cys Thr Thr 
            260                 265                 270         


Gly Ala Ala Cys Ala Thr Gly Ala Cys Ala Gly Cys Cys Ala Gly Cys 
        275                 280                 285             


Thr Ala Cys Thr Ala Cys Cys Ala Gly Ala Cys Ala Thr Ala Cys Thr 
    290                 295                 300                 


Gly Cys Cys Cys Cys Cys Cys Ala Ala Cys Thr Cys Cys Gly Gly Ala 
305                 310                 315                 320 


Ala Ala Cys Gly Gly Ala Cys Thr Gly Thr Gly Ala Ala Ala Cys Ala 
                325                 330                 335     


Cys Ala Ala Gly Thr Thr Ala Cys Cys Ala Cys Cys Thr Ala Thr Gly 
            340                 345                 350         


Cys Gly Gly Ala Thr Thr Thr Cys Ala Thr Ala Gly Ala Cys Ala Gly 
        355                 360                 365             


Cys Cys Thr Thr Ala Ala Ala Ala Cys Cys Thr Thr Thr Cys Thr Gly 
    370                 375                 380                 


Ala Cys Thr Thr Cys Ala Cys Cys Gly Gly Thr Ala Gly Gly Ala Gly 
385                 390                 395                 400 


Gly Gly Gly Cys Cys Ala Ala Cys Ala Thr Gly Thr Thr Cys Cys Ala 
                405                 410                 415     


Thr Gly Thr Thr Thr Cys Thr Thr Thr Thr Ala Gly Ala Thr Ala Thr 
            420                 425                 430         


Ala Thr Cys Thr Thr Thr Gly Gly Ala Ala Thr Thr Cys Cys Thr Cys 
        435                 440                 445             


Cys Ala Cys Thr Gly Ala Thr Cys Cys Thr Thr Gly Thr Thr Cys Thr 
    450                 455                 460                 


Gly Cys Thr Gly Cys Cys Thr Gly Thr Cys Ala Cys Ala Thr Cys Ala 
465                 470                 475                 480 


Thr Cys Thr Gly Ala Gly Thr Gly Cys Cys Ala Cys Ala Thr Thr Ala 
                485                 490                 495     


Ala Ala Gly Ala Cys Ala Ala Ala Gly Ala Ala Gly Gly Thr Ala Ala 
            500                 505                 510         


Ala Gly Cys Ala Thr Ala Thr Gly Ala Gly Ala Gly Thr Gly Thr Ala 
        515                 520                 525             


Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala Thr Cys Gly 
    530                 535                 540                 


Ala Thr Gly Ala Ala Thr Thr Gly Gly Ala Cys Ala Ala Ala Ala Thr 
545                 550                 555                 560 


Gly Ala Cys Ala Gly Gly Ala Ala Cys Thr Gly Ala Thr Ala Gly Thr 
                565                 570                 575     


Ala Ala Thr Thr Gly Cys Cys Cys Gly Ala Ala Thr Ala Ala Thr Gly 
            580                 585                 590         


Ala Ala Cys Cys Ala Ala Ala Cys Thr Thr Thr Thr Thr Thr Ala Gly 
        595                 600                 605             


Ala Ala Ala Ala Cys Ala Thr Gly Thr Ala Thr Gly Thr Gly Ala Thr 
    610                 615                 620                 


Gly Ala Thr Ala Cys Ala Ala Ala Gly Gly Ala Ala Gly Cys Thr Gly 
625                 630                 635                 640 


Cys Thr Thr Thr Thr Cys Thr Ala Ala Ala Thr Cys Gly Thr Gly Cys 
                645                 650                 655     


Thr Gly Cys Thr Cys Gly Cys Ala Ala Gly Thr Thr Gly Ala Ala Gly 
            660                 665                 670         


Cys Ala Ala Thr Thr Thr Cys Thr Thr Ala Ala Ala Ala Thr Gly Ala 
        675                 680                 685             


Ala Thr Ala Thr Cys Ala Gly Thr Gly Ala Ala Gly Ala Ala Thr Thr 
    690                 695                 700                 


Cys Ala Ala Thr Gly Thr Cys Cys Ala Cys Thr Thr Ala Cys Thr Ala 
705                 710                 715                 720 


Ala Cys Ala Gly Thr Ala Thr Cys Ala Cys Ala Ala Gly Gly Cys Ala 
                725                 730                 735     


Cys Ala Cys Ala Ala Ala Cys Ala Cys Thr Gly Gly Thr Gly Ala Ala 
            740                 745                 750         


Cys Thr Gly Cys Ala Cys Ala Ala Gly Thr Ala Ala Gly Gly Ala Ala 
        755                 760                 765             


Gly Ala Ala Ala Ala Ala Ala Ala Cys Gly Thr Ala Ala Ala Gly Gly 
    770                 775                 780                 


Ala Ala Cys Ala Gly Ala Ala Ala Ala Ala Gly Ala Ala Thr Gly Ala 
785                 790                 795                 800 


Thr Gly Cys Ala Thr Gly Thr Thr Thr Cys Cys Thr Ala Ala Ala Gly 
                805                 810                 815     


Ala Gly Ala Cys Thr Ala Cys Thr Gly Ala Gly Ala Gly Ala Ala Ala 
            820                 825                 830         


Thr Ala Ala Ala Ala Ala Cys Thr Thr Gly Thr Thr Gly Gly Ala Ala 
        835                 840                 845             


Thr Ala Ala Ala Ala Thr Thr Thr Thr Gly Ala Ala Gly Gly Gly Cys 
    850                 855                 860                 


Ala Gly Thr Ala Thr Ala Thr Ala Ala 
865                 870             


