                         SEQUENCE LISTING

<110>  Massachusetts Institute of Technology
       The Governors of the University of Alberta
       Klapoetke, Nathan
       Chow, Brian Y
       Boyden, Edward
       Wong, Gane K
 
<120>  CHANNELRHODOPSINS FOR OPTICAL CONTROL OF CELLS

<130>  ML01.004

<150>  61/559076
<151>  2011-11-12

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  669
<212>  PRT
<213>  Chlamydomonas noctigama

<400>  1

Met Ala Glu Leu Ile Ser Ser Ala Thr Arg Ser Leu Phe Ala Ala Gly 
1               5                   10                  15      


Gly Ile Asn Pro Trp Pro Asn Pro Tyr His His Glu Asp Met Gly Cys 
            20                  25                  30          


Gly Gly Met Thr Pro Thr Gly Glu Cys Phe Ser Thr Glu Trp Trp Cys 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Ser Asp Ala Gly Tyr Gly Tyr Cys Phe Val 
    50                  55                  60                  


Glu Ala Thr Gly Gly Tyr Leu Val Val Gly Val Glu Lys Lys Gln Ala 
65                  70                  75                  80  


Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val 
                85                  90                  95      


Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr 
            100                 105                 110         


Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val 
        115                 120                 125             


Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe 
    130                 135                 140                 


Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys 
145                 150                 155                 160 


Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys 
                165                 170                 175     


Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met 
            180                 185                 190         


Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly Met Ala Ala 
        195                 200                 205             


Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys 
    210                 215                 220                 


Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu 
225                 230                 235                 240 


Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val Val Lys Leu 
                245                 250                 255     


Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp 
            260                 265                 270         


Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser 
        275                 280                 285             


Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe 
    290                 295                 300                 


Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile Leu Ile His 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val 
                325                 330                 335     


Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr Val Thr His 
            340                 345                 350         


Pro Thr Ser Asn Leu Ala Asn Arg Asn Ser Phe Val Ile Met Ala Glu 
        355                 360                 365             


Arg Met Arg Ala Arg Gly Ile Asp Val Arg Ala Ser Leu Asp Arg Asn 
    370                 375                 380                 


Gly Pro Met Ile Glu Ser Gly Arg Val Ile Leu Ala Asp Thr Asp Ile 
385                 390                 395                 400 


Phe Val Thr Glu Met Phe Lys Ala Gln Phe Ala Gln Leu Pro Ala Ala 
                405                 410                 415     


Ile Glu Leu Ile Pro Ala Leu Gly Ala Asp Asn Ala Leu Gln Leu Val 
            420                 425                 430         


Gln Gln Ala Ser Val Leu Gly Gly Cys Asp Phe Val Met Val His Pro 
        435                 440                 445             


Gln Phe Leu Lys Asp Asn Ser Pro Ser Gly Leu Val Ala Arg Leu Arg 
    450                 455                 460                 


Met Met Gly Gln Arg Val Val Ala Phe Gly Pro Ala Asn Leu Arg Glu 
465                 470                 475                 480 


Leu Ile Glu Ser Cys Asp Val Asp Ala Trp Ile Glu Ala Pro Pro Ile 
                485                 490                 495     


Asn Leu Tyr Gln Leu Arg Gln Val Val Ala Gln Met Gln Leu Met Arg 
            500                 505                 510         


Arg Gln Ala Ala Met Met Gly Gly Met Gly Gly Gly Met Lys Gly Gly 
        515                 520                 525             


Met Ser Gly Met Gly Met Gly Met His Ala Gly Ser Met Trp Lys Gln 
    530                 535                 540                 


Gln Gln Met Met Met Gln Gln Asp Gly Ser Ala Met Met Met Pro Ala 
545                 550                 555                 560 


Met Gln Gly Gly Ala Ala Ser Met Arg Gly Ser Gly Leu Ile Ser Ala 
                565                 570                 575     


Gln Pro Gly Arg Gln Ala Ser Leu Gly Gly Pro Gln Ser Val Met Met 
            580                 585                 590         


Gly Ser Ala Met Val Gly Ser Asn Pro Leu Phe Gly Thr Ala Pro Ser 
        595                 600                 605             


Pro Leu Gly Ser Ala Val Gly Ala Glu Ala Met Gly His Asn Leu Tyr 
    610                 615                 620                 


Gly Asn Gln Ala Ala Ala Gly Gly Ile Pro Ala Ala Ser Ala Ala Ala 
625                 630                 635                 640 


Asp Gly Thr Asp Val Glu Met Met Gln Gln Leu Met Ser Glu Ile Asp 
                645                 650                 655     


Arg Leu Lys Gly Glu Leu Gly Glu Gln Asp Met Pro Arg 
            660                 665                 


<210>  2
<211>  350
<212>  PRT
<213>  Chlamydomonas noctigama

<400>  2

Met Ala Glu Leu Ile Ser Ser Ala Thr Arg Ser Leu Phe Ala Ala Gly 
1               5                   10                  15      


Gly Ile Asn Pro Trp Pro Asn Pro Tyr His His Glu Asp Met Gly Cys 
            20                  25                  30          


Gly Gly Met Thr Pro Thr Gly Glu Cys Phe Ser Thr Glu Trp Trp Cys 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Ser Asp Ala Gly Tyr Gly Tyr Cys Phe Val 
    50                  55                  60                  


Glu Ala Thr Gly Gly Tyr Leu Val Val Gly Val Glu Lys Lys Gln Ala 
65                  70                  75                  80  


Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val 
                85                  90                  95      


Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr 
            100                 105                 110         


Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val 
        115                 120                 125             


Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe 
    130                 135                 140                 


Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys 
145                 150                 155                 160 


Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys 
                165                 170                 175     


Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met 
            180                 185                 190         


Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly Met Ala Ala 
        195                 200                 205             


Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys 
    210                 215                 220                 


Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu 
225                 230                 235                 240 


Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val Val Lys Leu 
                245                 250                 255     


Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp 
            260                 265                 270         


Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser 
        275                 280                 285             


Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe 
    290                 295                 300                 


Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile Leu Ile His 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val 
                325                 330                 335     


Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr Val 
            340                 345                 350 


<210>  3
<211>  1050
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide, Mammalian-condon optimized DNA

<400>  3
atggctgagc tgatcagcag cgccaccaga tctctgtttg ccgccggagg catcaaccct       60

tggcctaacc cctaccacca cgaggacatg ggctgtggag gaatgacacc tacaggcgag      120

tgcttcagca ccgagtggtg gtgtgaccct tcttacggac tgagcgacgc cggatacgga      180

tattgcttcg tggaggccac aggcggctac ctggtcgtgg gagtggagaa gaagcaggct      240

tggctgcaca gcagaggcac accaggagaa aagatcggcg cccaggtctg ccagtggatt      300

gctttcagca tcgccatcgc cctgctgaca ttctacggct tcagcgcctg gaaggccact      360

tgcggttggg aggaggtcta cgtctgttgc gtcgaggtgc tgttcgtgac cctggagatc      420

ttcaaggagt tcagcagccc cgccacagtg tacctgtcta ccggcaacca cgcctattgc      480

ctgcgctact tcgagtggct gctgtcttgc cccgtgatcc tgatcaagct gagcaacctg      540

agcggcctga agaacgacta cagcaagcgg accatgggcc tgatcgtgtc ttgcgtggga      600

atgatcgtgt tcggcatggc cgcaggactg gctaccgatt ggctcaagtg gctgctgtat      660

atcgtgtctt gcatctacgg cggctacatg tacttccagg ccgccaagtg ctacgtggaa      720

gccaaccaca gcgtgcctaa aggccattgc cgcatggtcg tgaagctgat ggcctacgct      780

tacttcgcct cttggggcag ctacccaatc ctctgggcag tgggaccaga aggactgctg      840

aagctgagcc cttacgccaa cagcatcggc cacagcatct gcgacatcat cgccaaggag      900

ttttggacct tcctggccca ccacctgagg atcaagatcc acgagcacat cctgatccac      960

ggcgacatcc ggaagaccac caagatggag atcggaggcg aggaggtgga agtggaagag     1020

ttcgtggagg aggaggacga ggacacagtg                                      1050


<210>  4
<211>  235
<212>  PRT
<213>  Chlamydomonas noctigama

<400>  4

Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val Cys Gln Trp Ile Ala 
1               5                   10                  15      


Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr Gly Phe Ser Ala Trp 
            20                  25                  30          


Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Cys Cys Val Glu Val 
        35                  40                  45              


Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe Ser Ser Pro Ala Thr 
    50                  55                  60                  


Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys Leu Arg Tyr Phe Glu 
65                  70                  75                  80  


Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Lys Leu Ser Asn Leu Ser 
                85                  90                  95      


Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met Gly Leu Ile Val Ser 
            100                 105                 110         


Cys Val Gly Met Ile Val Phe Gly Met Ala Ala Gly Leu Ala Thr Asp 
        115                 120                 125             


Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys Ile Tyr Gly Gly Tyr 
    130                 135                 140                 


Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu Ala Asn His Ser Val 
145                 150                 155                 160 


Pro Lys Gly His Cys Arg Met Val Val Lys Leu Met Ala Tyr Ala Tyr 
                165                 170                 175     


Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp Ala Val Gly Pro Glu 
            180                 185                 190         


Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser Ile Gly His Ser Ile 
        195                 200                 205             


Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe Leu Ala His His Leu 
    210                 215                 220                 


Arg Ile Lys Ile His Glu His Ile Leu Ile His 
225                 230                 235 


<210>  5
<211>  350
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  5

Met Ala Glu Leu Ile Ser Ser Ala Thr Arg Ser Leu Phe Ala Ala Gly 
1               5                   10                  15      


Gly Ile Asn Pro Trp Pro Asn Pro Tyr His His Glu Asp Met Gly Cys 
            20                  25                  30          


Gly Gly Met Thr Pro Thr Gly Glu Cys Phe Ser Thr Glu Trp Trp Cys 
        35                  40                  45              


Asp Pro Ser Tyr Gly Leu Ser Asp Ala Gly Tyr Gly Tyr Cys Phe Val 
    50                  55                  60                  


Glu Ala Thr Gly Gly Tyr Leu Val Val Gly Val Glu Lys Lys Gln Ala 
65                  70                  75                  80  


Trp Leu His Ser Arg Gly Thr Pro Gly Glu Lys Ile Gly Ala Gln Val 
                85                  90                  95      


Cys Gln Trp Ile Ala Phe Ser Ile Ala Ile Ala Leu Leu Thr Phe Tyr 
            100                 105                 110         


Gly Phe Ser Ala Trp Lys Ala Thr Cys Gly Trp Glu Glu Val Tyr Val 
        115                 120                 125             


Cys Cys Val Glu Val Leu Phe Val Thr Leu Glu Ile Phe Lys Glu Phe 
    130                 135                 140                 


Ser Ser Pro Ala Thr Val Tyr Leu Ser Thr Gly Asn His Ala Tyr Cys 
145                 150                 155                 160 


Leu Arg Tyr Phe Glu Trp Leu Leu Ser Cys Pro Val Ile Leu Ile Arg 
                165                 170                 175     


Leu Ser Asn Leu Ser Gly Leu Lys Asn Asp Tyr Ser Lys Arg Thr Met 
            180                 185                 190         


Gly Leu Ile Val Ser Cys Val Gly Met Ile Val Phe Gly Met Ala Ala 
        195                 200                 205             


Gly Leu Ala Thr Asp Trp Leu Lys Trp Leu Leu Tyr Ile Val Ser Cys 
    210                 215                 220                 


Ile Tyr Gly Gly Tyr Met Tyr Phe Gln Ala Ala Lys Cys Tyr Val Glu 
225                 230                 235                 240 


Ala Asn His Ser Val Pro Lys Gly His Cys Arg Met Val Val Lys Leu 
                245                 250                 255     


Met Ala Tyr Ala Tyr Phe Ala Ser Trp Gly Ser Tyr Pro Ile Leu Trp 
            260                 265                 270         


Ala Val Gly Pro Glu Gly Leu Leu Lys Leu Ser Pro Tyr Ala Asn Ser 
        275                 280                 285             


Ile Gly His Ser Ile Cys Asp Ile Ile Ala Lys Glu Phe Trp Thr Phe 
    290                 295                 300                 


Leu Ala His His Leu Arg Ile Lys Ile His Glu His Ile Leu Ile His 
305                 310                 315                 320 


Gly Asp Ile Arg Lys Thr Thr Lys Met Glu Ile Gly Gly Glu Glu Val 
                325                 330                 335     


Glu Val Glu Glu Phe Val Glu Glu Glu Asp Glu Asp Thr Val 
            340                 345                 350 


<210>  6
<211>  421
<212>  PRT
<213>  Stigeoclonium helveticum

<400>  6

Met Glu Thr Ala Ala Thr Met Thr His Ala Phe Ile Ser Ala Val Pro 
1               5                   10                  15      


Ser Ala Glu Ala Thr Ile Arg Gly Leu Leu Ser Ala Ala Ala Val Val 
            20                  25                  30          


Thr Pro Ala Ala Asp Ala His Gly Glu Thr Ser Asn Ala Thr Thr Ala 
        35                  40                  45              


Gly Ala Asp His Gly Cys Phe Pro His Ile Asn His Gly Thr Glu Leu 
    50                  55                  60                  


Gln His Lys Ile Ala Val Gly Leu Gln Trp Phe Thr Val Ile Val Ala 
65                  70                  75                  80  


Ile Val Gln Leu Ile Phe Tyr Gly Trp His Ser Phe Lys Ala Thr Thr 
                85                  90                  95      


Gly Trp Glu Glu Val Tyr Val Cys Val Ile Glu Leu Val Lys Cys Phe 
            100                 105                 110         


Ile Glu Leu Phe His Glu Val Asp Ser Pro Ala Thr Val Tyr Gln Thr 
        115                 120                 125             


Asn Gly Gly Ala Val Ile Trp Leu Arg Tyr Ser Met Trp Leu Leu Thr 
    130                 135                 140                 


Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu His Glu 
145                 150                 155                 160 


Glu Tyr Ser Lys Arg Thr Met Thr Ile Leu Val Thr Asp Ile Gly Asn 
                165                 170                 175     


Ile Val Trp Gly Ile Thr Ala Ala Phe Thr Lys Gly Pro Leu Lys Ile 
            180                 185                 190         


Leu Phe Phe Met Ile Gly Leu Phe Tyr Gly Val Thr Cys Phe Phe Gln 
        195                 200                 205             


Ile Ala Lys Val Tyr Ile Glu Ser Tyr His Thr Leu Pro Lys Gly Val 
    210                 215                 220                 


Cys Arg Lys Ile Cys Lys Ile Met Ala Tyr Val Phe Phe Cys Ser Trp 
225                 230                 235                 240 


Leu Met Phe Pro Val Met Phe Ile Ala Gly His Glu Gly Leu Gly Leu 
                245                 250                 255     


Ile Thr Pro Tyr Thr Ser Gly Ile Gly His Leu Ile Leu Asp Leu Ile 
            260                 265                 270         


Ser Lys Asn Thr Trp Gly Phe Leu Gly His His Leu Arg Val Lys Ile 
        275                 280                 285             


His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Thr Ile 
    290                 295                 300                 


Asn Val Ala Gly Glu Asn Met Glu Ile Glu Thr Phe Val Asp Glu Glu 
305                 310                 315                 320 


Glu Glu Gly Gly Val Asn His Gly Thr Ala Asp Leu Ala His Arg Ala 
                325                 330                 335     


Ser Phe Gln Lys Met Gly Asp Arg Leu Arg Ala Gln Gly Val Thr Val 
            340                 345                 350         


Arg Ala Ser Leu Asp Ala His Glu Val Pro Pro Ala Asp Glu Glu Asn 
        355                 360                 365             


Lys Phe Ala Gln Lys Ser Ala Ala Ala Asn Met Pro Ala Tyr Asn Pro 
    370                 375                 380                 


Gly Lys Val Ile Leu Ile Val Pro Asp Met Ser Met Val Asp Tyr Phe 
385                 390                 395                 400 


Arg Asp Gln Phe Glu Gln Leu Pro Thr Arg Met Glu Leu Leu Pro Ala 
                405                 410                 415     


Leu Gly Met Asp Thr 
            420     


<210>  7
<211>  325
<212>  PRT
<213>  Stigeoclonium helveticum

<400>  7

Met Glu Thr Ala Ala Thr Met Thr His Ala Phe Ile Ser Ala Val Pro 
1               5                   10                  15      


Ser Ala Glu Ala Thr Ile Arg Gly Leu Leu Ser Ala Ala Ala Val Val 
            20                  25                  30          


Thr Pro Ala Ala Asp Ala His Gly Glu Thr Ser Asn Ala Thr Thr Ala 
        35                  40                  45              


Gly Ala Asp His Gly Cys Phe Pro His Ile Asn His Gly Thr Glu Leu 
    50                  55                  60                  


Gln His Lys Ile Ala Val Gly Leu Gln Trp Phe Thr Val Ile Val Ala 
65                  70                  75                  80  


Ile Val Gln Leu Ile Phe Tyr Gly Trp His Ser Phe Lys Ala Thr Thr 
                85                  90                  95      


Gly Trp Glu Glu Val Tyr Val Cys Val Ile Glu Leu Val Lys Cys Phe 
            100                 105                 110         


Ile Glu Leu Phe His Glu Val Asp Ser Pro Ala Thr Val Tyr Gln Thr 
        115                 120                 125             


Asn Gly Gly Ala Val Ile Trp Leu Arg Tyr Ser Met Trp Leu Leu Thr 
    130                 135                 140                 


Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu His Glu 
145                 150                 155                 160 


Glu Tyr Ser Lys Arg Thr Met Thr Ile Leu Val Thr Asp Ile Gly Asn 
                165                 170                 175     


Ile Val Trp Gly Ile Thr Ala Ala Phe Thr Lys Gly Pro Leu Lys Ile 
            180                 185                 190         


Leu Phe Phe Met Ile Gly Leu Phe Tyr Gly Val Thr Cys Phe Phe Gln 
        195                 200                 205             


Ile Ala Lys Val Tyr Ile Glu Ser Tyr His Thr Leu Pro Lys Gly Val 
    210                 215                 220                 


Cys Arg Lys Ile Cys Lys Ile Met Ala Tyr Val Phe Phe Cys Ser Trp 
225                 230                 235                 240 


Leu Met Phe Pro Val Met Phe Ile Ala Gly His Glu Gly Leu Gly Leu 
                245                 250                 255     


Ile Thr Pro Tyr Thr Ser Gly Ile Gly His Leu Ile Leu Asp Leu Ile 
            260                 265                 270         


Ser Lys Asn Thr Trp Gly Phe Leu Gly His His Leu Arg Val Lys Ile 
        275                 280                 285             


His Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Thr Ile 
    290                 295                 300                 


Asn Val Ala Gly Glu Asn Met Glu Ile Glu Thr Phe Val Asp Glu Glu 
305                 310                 315                 320 


Glu Glu Gly Gly Val 
                325 


<210>  8
<211>  975
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide, Mammalian-condon optimized DNA

<400>  8
atggaaacag ccgccacaat gacccacgcc tttatctcag ccgtgcctag cgccgaagcc       60

acaattagag gcctgctgag cgccgcagca gtggtgacac cagcagcaga cgctcacgga      120

gaaacctcta acgccacaac agccggagcc gatcacggtt gcttccccca catcaaccac      180

ggaaccgagc tgcagcacaa gatcgcagtg ggactccagt ggttcaccgt gatcgtggct      240

atcgtgcagc tcatcttcta cggttggcac agcttcaagg ccacaaccgg ctgggaggag      300

gtctacgtct gcgtgatcga gctcgtcaag tgcttcatcg agctgttcca cgaggtcgac      360

agcccagcca cagtgtacca gaccaacgga ggagccgtga tttggctgcg gtacagcatg      420

tggctcctga cttgccccgt gatcctgatc cacctgagca acctgaccgg actgcacgaa      480

gagtacagca agcggaccat gaccatcctg gtgaccgaca tcggcaacat cgtgtggggg      540

atcacagccg cctttacaaa gggccccctg aagatcctgt tcttcatgat cggcctgttc      600

tacggcgtga cttgcttctt ccagatcgcc aaggtgtata tcgagagcta ccacaccctg      660

cccaaaggcg tctgccggaa gatttgcaag atcatggcct acgtcttctt ctgctcttgg      720

ctgatgttcc ccgtgatgtt catcgccgga cacgagggac tgggcctgat cacaccttac      780

accagcggaa tcggccacct gatcctggat ctgatcagca agaacacttg gggcttcctg      840

ggccaccacc tgagagtgaa gatccacgag cacatcctga tccacggcga catccggaag      900

acaaccacca tcaacgtggc cggcgagaac atggagatcg agaccttcgt cgacgaggag      960

gaggagggag gagtg                                                       975


<210>  9
<211>  235
<212>  PRT
<213>  Stigeoclonium helveticum

<400>  9

Gly Thr Glu Leu Gln His Lys Ile Ala Val Gly Leu Gln Trp Phe Thr 
1               5                   10                  15      


Val Ile Val Ala Ile Val Gln Leu Ile Phe Tyr Gly Trp His Ser Phe 
            20                  25                  30          


Lys Ala Thr Thr Gly Trp Glu Glu Val Tyr Val Cys Val Ile Glu Leu 
        35                  40                  45              


Val Lys Cys Phe Ile Glu Leu Phe His Glu Val Asp Ser Pro Ala Thr 
    50                  55                  60                  


Val Tyr Gln Thr Asn Gly Gly Ala Val Ile Trp Leu Arg Tyr Ser Met 
65                  70                  75                  80  


Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr 
                85                  90                  95      


Gly Leu His Glu Glu Tyr Ser Lys Arg Thr Met Thr Ile Leu Val Thr 
            100                 105                 110         


Asp Ile Gly Asn Ile Val Trp Gly Ile Thr Ala Ala Phe Thr Lys Gly 
        115                 120                 125             


Pro Leu Lys Ile Leu Phe Phe Met Ile Gly Leu Phe Tyr Gly Val Thr 
    130                 135                 140                 


Cys Phe Phe Gln Ile Ala Lys Val Tyr Ile Glu Ser Tyr His Thr Leu 
145                 150                 155                 160 


Pro Lys Gly Val Cys Arg Lys Ile Cys Lys Ile Met Ala Tyr Val Phe 
                165                 170                 175     


Phe Cys Ser Trp Leu Met Phe Pro Val Met Phe Ile Ala Gly His Glu 
            180                 185                 190         


Gly Leu Gly Leu Ile Thr Pro Tyr Thr Ser Gly Ile Gly His Leu Ile 
        195                 200                 205             


Leu Asp Leu Ile Ser Lys Asn Thr Trp Gly Phe Leu Gly His His Leu 
    210                 215                 220                 


Arg Val Lys Ile His Glu His Ile Leu Ile His 
225                 230                 235 


<210>  10
<211>  457
<212>  PRT
<213>  Chloromonas subdivisa

<400>  10

Met Ser Arg Leu Val Ala Ala Ser Trp Leu Leu Ala Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Thr Thr Ala Ser Ser Ala Pro Ala Ala Ser Ser 
            20                  25                  30          


Thr Asp Gly Thr Ala Ala Ala Ala Val Ser His Tyr Ala Met Asn Gly 
        35                  40                  45              


Phe Asp Glu Leu Ala Lys Gly Ala Val Val Pro Glu Asp His Phe Val 
    50                  55                  60                  


Cys Gly Pro Ala Asp Lys Cys Tyr Cys Ser Ala Trp Leu His Ser His 
65                  70                  75                  80  


Gly Ser Lys Glu Glu Lys Thr Ala Phe Thr Val Met Gln Trp Ile Val 
                85                  90                  95      


Phe Ala Val Cys Ile Ile Ser Leu Leu Phe Tyr Ala Tyr Gln Thr Trp 
            100                 105                 110         


Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Thr Ile Ile Glu Leu 
        115                 120                 125             


Val His Val Cys Phe Gly Leu Trp His Glu Val Asp Ser Pro Cys Thr 
    130                 135                 140                 


Leu Tyr Leu Ser Thr Gly Asn Met Val Leu Trp Leu Arg Tyr Ala Glu 
145                 150                 155                 160 


Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr 
                165                 170                 175     


Gly Met Lys Asn Asp Tyr Asn Lys Arg Thr Met Ala Leu Leu Val Ser 
            180                 185                 190         


Asp Val Gly Cys Ile Val Trp Gly Thr Thr Ala Ala Leu Ser Thr Asp 
        195                 200                 205             


Phe Val Lys Ile Ile Phe Phe Phe Leu Gly Leu Leu Tyr Gly Phe Tyr 
    210                 215                 220                 


Thr Phe Tyr Ala Ala Ala Lys Ile Tyr Ile Glu Ala Tyr His Thr Val 
225                 230                 235                 240 


Pro Lys Gly Ile Cys Arg Gln Leu Val Arg Leu Gln Ala Tyr Asp Phe 
                245                 250                 255     


Phe Phe Thr Trp Ser Met Phe Pro Ile Leu Phe Met Val Gly Pro Glu 
            260                 265                 270         


Gly Phe Gly Lys Ile Thr Ala Tyr Ser Ser Gly Ile Ala His Glu Val 
        275                 280                 285             


Cys Asp Leu Leu Ser Lys Asn Leu Trp Gly Leu Met Gly His Phe Ile 
    290                 295                 300                 


Arg Val Lys Ile His Glu His Ile Leu Val His Gly Asn Ile Thr Lys 
305                 310                 315                 320 


Lys Thr Lys Val Asn Val Ala Gly Asp Met Val Glu Leu Asp Thr Tyr 
                325                 330                 335     


Val Asp Gln Asp Glu Glu His Asp Glu Gly Thr Ile Asp Arg Gly Thr 
            340                 345                 350         


Gln Glu Leu Ala Asn Arg His Ser Phe Val Val Met Arg Glu Asn Met 
        355                 360                 365             


Arg Ala Lys Gly Val Asp Val Arg Ala Ser Leu Gly Asp Ile Asp Gly 
    370                 375                 380                 


Thr Glu Met Thr Lys Ala Gly Asn Met Asn Gly Thr Leu Glu Pro Gly 
385                 390                 395                 400 


Arg Ile Ile Leu Cys Val Pro Asp Met Ser Leu Val Asp Phe Phe Arg 
                405                 410                 415     


Glu Gln Phe Ser Gln Met Pro Val Pro Phe Glu Val Val Pro Ala Leu 
            420                 425                 430         


Gly Pro Glu Val Ala Leu Gln Leu Val Gln Gln Ala Leu Ser Ile Gly 
        435                 440                 445             


Gly Ala Asn Tyr Ile Asp Tyr Val Met 
    450                 455         


<210>  11
<211>  346
<212>  PRT
<213>  Chloromonas subdivisa

<400>  11

Met Ser Arg Leu Val Ala Ala Ser Trp Leu Leu Ala Leu Leu Leu Cys 
1               5                   10                  15      


Gly Ile Thr Ser Thr Thr Thr Ala Ser Ser Ala Pro Ala Ala Ser Ser 
            20                  25                  30          


Thr Asp Gly Thr Ala Ala Ala Ala Val Ser His Tyr Ala Met Asn Gly 
        35                  40                  45              


Phe Asp Glu Leu Ala Lys Gly Ala Val Val Pro Glu Asp His Phe Val 
    50                  55                  60                  


Cys Gly Pro Ala Asp Lys Cys Tyr Cys Ser Ala Trp Leu His Ser His 
65                  70                  75                  80  


Gly Ser Lys Glu Glu Lys Thr Ala Phe Thr Val Met Gln Trp Ile Val 
                85                  90                  95      


Phe Ala Val Cys Ile Ile Ser Leu Leu Phe Tyr Ala Tyr Gln Thr Trp 
            100                 105                 110         


Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Thr Ile Ile Glu Leu 
        115                 120                 125             


Val His Val Cys Phe Gly Leu Trp His Glu Val Asp Ser Pro Cys Thr 
    130                 135                 140                 


Leu Tyr Leu Ser Thr Gly Asn Met Val Leu Trp Leu Arg Tyr Ala Glu 
145                 150                 155                 160 


Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr 
                165                 170                 175     


Gly Met Lys Asn Asp Tyr Asn Lys Arg Thr Met Ala Leu Leu Val Ser 
            180                 185                 190         


Asp Val Gly Cys Ile Val Trp Gly Thr Thr Ala Ala Leu Ser Thr Asp 
        195                 200                 205             


Phe Val Lys Ile Ile Phe Phe Phe Leu Gly Leu Leu Tyr Gly Phe Tyr 
    210                 215                 220                 


Thr Phe Tyr Ala Ala Ala Lys Ile Tyr Ile Glu Ala Tyr His Thr Val 
225                 230                 235                 240 


Pro Lys Gly Ile Cys Arg Gln Leu Val Arg Leu Gln Ala Tyr Asp Phe 
                245                 250                 255     


Phe Phe Thr Trp Ser Met Phe Pro Ile Leu Phe Met Val Gly Pro Glu 
            260                 265                 270         


Gly Phe Gly Lys Ile Thr Ala Tyr Ser Ser Gly Ile Ala His Glu Val 
        275                 280                 285             


Cys Asp Leu Leu Ser Lys Asn Leu Trp Gly Leu Met Gly His Phe Ile 
    290                 295                 300                 


Arg Val Lys Ile His Glu His Ile Leu Val His Gly Asn Ile Thr Lys 
305                 310                 315                 320 


Lys Thr Lys Val Asn Val Ala Gly Asp Met Val Glu Leu Asp Thr Tyr 
                325                 330                 335     


Val Asp Gln Asp Glu Glu His Asp Glu Gly 
            340                 345     


<210>  12
<211>  1038
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide, Mammalian-codon optimized DNA

<400>  12
atgagcagac tggtcgccgc ttcttggctg ctggctctcc tcctctgcgg aattaccagc       60

acaacaacag cctctagcgc cccagcagct tcttctacag acggaacagc cgccgcagca      120

gtgtctcact acgccatgaa cggcttcgac gagctggcta aaggagccgt ggtgccagaa      180

gaccactttg tctgcggacc agccgacaag tgctattgct ccgcttggct gcacagccac      240

ggaagcaagg aggagaagac cgccttcacc gtcatgcagt ggatcgtgtt cgccgtctgc      300

atcatcagcc tgctgttcta cgcctaccag acttggaggg ctacttgcgg ttgggaggag      360

gtgtacgtga ccatcatcga gctggtccac gtctgcttcg gactctggca cgaggtcgat      420

agcccttgta ccctgtacct gagcacaggc aacatggtcc tctggctgag atacgccgag      480

tggctgctga cttgccccgt gatcctgatc cacctgagca acctgaccgg catgaagaac      540

gactacaaca agcggaccat ggccctgctg gtgtcagacg tgggctgtat cgtgtgggga      600

acaacagccg ccctgagcac cgatttcgtg aagatcatct tcttcttcct gggcctgctg      660

tacggcttct acaccttcta cgccgccgcc aagatctaca tcgaggccta ccacaccgtg      720

cccaagggca tttgtagaca gctcgtgcgg ctgcaggcct acgacttctt cttcacttgg      780

agcatgttcc ccatcctgtt catggtcggc ccagagggat tcggcaagat caccgcctac      840

agcagcggaa tcgcccacga agtgtgcgat ctgctgagca agaacctctg gggcctgatg      900

ggccacttca tccgcgtgaa gatccacgag cacatcctgg tgcacggcaa catcaccaag      960

aagaccaagg tcaacgtggc cggcgacatg gtggaactgg acacctacgt ggaccaggac     1020

gaggaacacg acgaggga                                                   1038


<210>  13
<211>  235
<212>  PRT
<213>  Chloromonas subdivisa

<400>  13

Gly Ser Lys Glu Glu Lys Thr Ala Phe Thr Val Met Gln Trp Ile Val 
1               5                   10                  15      


Phe Ala Val Cys Ile Ile Ser Leu Leu Phe Tyr Ala Tyr Gln Thr Trp 
            20                  25                  30          


Arg Ala Thr Cys Gly Trp Glu Glu Val Tyr Val Thr Ile Ile Glu Leu 
        35                  40                  45              


Val His Val Cys Phe Gly Leu Trp His Glu Val Asp Ser Pro Cys Thr 
    50                  55                  60                  


Leu Tyr Leu Ser Thr Gly Asn Met Val Leu Trp Leu Arg Tyr Ala Glu 
65                  70                  75                  80  


Trp Leu Leu Thr Cys Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr 
                85                  90                  95      


Gly Met Lys Asn Asp Tyr Asn Lys Arg Thr Met Ala Leu Leu Val Ser 
            100                 105                 110         


Asp Val Gly Cys Ile Val Trp Gly Thr Thr Ala Ala Leu Ser Thr Asp 
        115                 120                 125             


Phe Val Lys Ile Ile Phe Phe Phe Leu Gly Leu Leu Tyr Gly Phe Tyr 
    130                 135                 140                 


Thr Phe Tyr Ala Ala Ala Lys Ile Tyr Ile Glu Ala Tyr His Thr Val 
145                 150                 155                 160 


Pro Lys Gly Ile Cys Arg Gln Leu Val Arg Leu Gln Ala Tyr Asp Phe 
                165                 170                 175     


Phe Phe Thr Trp Ser Met Phe Pro Ile Leu Phe Met Val Gly Pro Glu 
            180                 185                 190         


Gly Phe Gly Lys Ile Thr Ala Tyr Ser Ser Gly Ile Ala His Glu Val 
        195                 200                 205             


Cys Asp Leu Leu Ser Lys Asn Leu Trp Gly Leu Met Gly His Phe Ile 
    210                 215                 220                 


Arg Val Lys Ile His Glu His Ile Leu Val His 
225                 230                 235 


<210>  14
<211>  310
<212>  PRT
<213>  Neochlorosarcina

<400>  14

Met Ala Asp Phe Val Trp Gln Gly Ala Gly Asn Gly Gly Pro Ser Ala 
1               5                   10                  15      


Met Val Ser His Tyr Pro Asn Gly Ser Val Leu Leu Glu Ser Ser Gly 
            20                  25                  30          


Ser Cys Tyr Cys Glu Asp Trp Tyr Thr Ser Arg Gly Asn His Val Glu 
        35                  40                  45              


His Ser Leu Ser Asn Ala Cys Asp Trp Phe Ala Phe Ala Ile Ser Val 
    50                  55                  60                  


Ile Phe Leu Val Tyr Tyr Ala Trp Ala Ala Phe Asn Ser Ser Val Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Thr Val Glu Leu Ile Lys Val Ser Ile 
                85                  90                  95      


Asp Gln Phe Leu Ser Ser Asn Ser Pro Cys Thr Leu Tyr Leu Ser Thr 
            100                 105                 110         


Gly Asn Arg Val Leu Trp Ile Arg Tyr Gly Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Val Thr Gly Leu Lys Asp Asn 
    130                 135                 140                 


Tyr Ser Lys Arg Thr Met Ala Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Phe Gly Val Thr Ser Ala Met Cys Thr Gly Tyr Pro Lys Val Ile 
                165                 170                 175     


Phe Phe Ile Leu Gly Cys Cys Tyr Gly Ala Asn Thr Phe Phe Asn Ala 
            180                 185                 190         


Ala Lys Val Tyr Leu Glu Ala His His Thr Leu Pro Lys Gly Ser Cys 
        195                 200                 205             


Arg Thr Leu Ile Arg Leu Met Ala Tyr Thr Tyr Tyr Ala Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Val Leu Gly Pro Glu Ser Phe Gly His Met 
225                 230                 235                 240 


Asn Met Tyr Gln Ser Asn Ile Ala His Thr Val Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Ile Trp Gly Met Leu Gly His Phe Leu Arg His Lys Ile Arg 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Leu Arg Thr Thr Thr Thr Val Asn 
        275                 280                 285             


Val Ala Gly Glu Glu Met Gln Val Glu Thr Met Val Ala Ala Glu Asp 
    290                 295                 300                 


Ala Asp Glu Thr Thr Val 
305                 310 


<210>  15
<211>  930
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucletide; Mammalian-condon optimized DNA

<400>  15
atggccgact tcgtgtggca gggagctgga aacggaggac caagcgccat ggtgtcccac       60

taccccaatg gcagcgtgct gctggagagc tccggcagct gctactgtga agactggtat      120

acttctcggg gcaaccacgt ggagcattct ctgagtaatg cttgcgattg gttcgccttt      180

gctatcagcg tgattttcct ggtgtactat gcctgggccg cttttaactc tagtgtgggc      240

tgggaggaaa tctacgtgtg caccgtggag ctgatcaagg tgagcattga tcagttcctg      300

agctccaact ctccttgtac cctgtacctg agtacaggga atagggtgct gtggatcaga      360

tatggcgaat ggctgctgac ttgtccagtg atcctgattc acctgtccaa cgtgacaggg      420

ctgaaggaca attactctaa acgcactatg gctctgctgg tgagtgatat cgggaccatc      480

gtgttcggcg tgacttctgc catgtgcacc ggatacccca aagtgatctt ctttattctg      540

ggctgctgtt atggagctaa cacattcttt aatgccgcta aggtgtacct ggaggcccac      600

catacactgc ctaaaggctc ttgtaggact ctgatcagac tgatggccta tacctactat      660

gctagttggg gaatgttccc cattctgttt gtgctgggac ctgagagctt cggccacatg      720

aacatgtacc agtccaatat cgcccatacc gtgattgacc tgatgtccaa gaacatctgg      780

ggaatgctgg ggcactttct gcggcataaa attcgcgagc acatcctgat tcatggagat      840

ctgcggacca caactaccgt gaatgtggct ggggaggaaa tgcaggtgga aacaatggtg      900

gccgctgagg acgccgatga aacaactgtg                                       930


<210>  16
<211>  304
<212>  PRT
<213>  Heterochlamydomonas inaequalis

<400>  16

Met Gly Gly Ile Gly Gly Gly Gly Ile Gln Pro Arg Asp Tyr Ser Tyr 
1               5                   10                  15      


Gly Ala Asn Gly Thr Val Cys Val Asn Pro Asp Val Cys Phe Cys Leu 
            20                  25                  30          


Asp Trp Gln Gln Pro Phe Gly Ser Asn Met Glu Asn Asn Val Ser Gln 
        35                  40                  45              


Gly Phe Gln Leu Phe Thr Ile Ala Leu Ser Ala Cys Ile Leu Met Phe 
    50                  55                  60                  


Tyr Ala Tyr Glu Trp Tyr Lys Ala Thr Cys Gly Trp Glu Glu Ile Tyr 
65                  70                  75                  80  


Val Cys Val Val Glu Met Ser Lys Ile Cys Ile Glu Leu Val His Glu 
                85                  90                  95      


Tyr Asp Thr Pro Phe Cys Leu Tyr Leu Ala Thr Gly Ser Arg Val Leu 
            100                 105                 110         


Trp Leu Arg Tyr Ala Glu Trp Leu Met Thr Cys Pro Val Ile Leu Ile 
        115                 120                 125             


His Leu Ser Asn Ile Thr Gly Leu Gly Thr Asp Tyr Asn Lys Arg Thr 
    130                 135                 140                 


Met Val Leu Leu Met Ser Asp Ile Gly Cys Ile Val Phe Gly Ala Thr 
145                 150                 155                 160 


Ala Ala Phe Ala Asn Glu Gly Tyr Val Lys Cys Ala Cys Phe Leu Leu 
                165                 170                 175     


Gly Met Ala Trp Gly Met Asn Thr Phe Tyr Asn Ala Ala Lys Val Tyr 
            180                 185                 190         


Tyr Glu Ser Tyr Val Leu Val Pro Ser Gly Ile Cys Lys Leu Leu Val 
        195                 200                 205             


Ala Val Met Ala Gly Leu Tyr Tyr Val Ser Trp Ser Leu Phe Pro Ile 
    210                 215                 220                 


Leu Phe Ala Ile Gly Pro Glu Gly Phe Gly Val Ile Ser Leu Gln Ala 
225                 230                 235                 240 


Ser Thr Ile Gly His Thr Ile Ala Asp Val Leu Ser Lys Asn Met Trp 
                245                 250                 255     


Gly Leu Met Gly His Phe Leu Arg Val Gln Ile Tyr Lys His Ile Leu 
            260                 265                 270         


Leu His Gly Asn Ile Arg Lys Pro Ile Lys Leu His Met Leu Gly Glu 
        275                 280                 285             


Glu Val Glu Val Met Ala Leu Val Ser Glu Glu Gly Glu Asp Thr Val 
    290                 295                 300                 


<210>  17
<211>  912
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide; Mammalian-condon optimized DNA

<400>  17
atgggaggaa ttggcggagg cggcattcag cctagagact acagctacgg cgccaacgga       60

acagtctgcg tgaaccccga cgtctgcttc tgtctggatt ggcagcagcc cttcggctct      120

aacatggaga acaacgtgtc ccagggcttc cagctgttta ccatcgccct gagcgcctgc      180

atcctgatgt tctacgccta cgagtggtac aaggccactt gcggttggga ggagatctac      240

gtctgcgtgg tggagatgag caagatttgc atcgagctgg tgcacgagta cgacaccccc      300

ttttgcctgt acctggccac cggcagcaga gtcctctggc tgagatacgc cgagtggctc      360

atgacttgcc ccgtgatcct gatccacctg agcaacatca ccggactggg caccgactac      420

aacaagcgga ccatggtgct cctgatgagc gacatcggtt gcatcgtgtt cggcgccaca      480

gcagcattcg ccaacgaggg ctacgtgaag tgcgcttgtt tcctgctggg catggcttgg      540

ggcatgaaca ccttctacaa cgccgccaag gtgtactacg agagctacgt gctggtgccc      600

tccggaattt gcaagctgct ggtggccgtg atggccggac tgtactacgt gtcttggagc      660

ctgttcccca tcctgtttgc catcggccca gagggatttg gcgtgatcag cctgcaggcc      720

agcaccattg gccacacaat cgccgacgtg ctgagcaaga acatgtgggg cctgatgggc      780

cacttcctgc gggtgcagat ctacaagcac atcctgctgc acggcaacat ccggaagcct      840

atcaagctgc acatgctggg cgaggaggtg gaagtgatgg ctctggtgtc cgaggaggga      900

gaggataccg tg                                                          912


<210>  18
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide; Mammalian-condon optimized DNA

<400>  18
atggactatg gcggcgcttt gtctgccgtc ggacgcgaac ttttgttcgt tactaatcct       60

gtggtggtga acgggtccgt cctggtccct gaggatcaat gttactgtgc cggatggatt      120

gaatctcgcg gcacgaacgg cgctcagacc gcgtcaaatg tcctgcagtg gcttgcagca      180

ggattcagca ttttgctgct gatgttctat gcctaccaaa cctggaaatc tacatgcggc      240

tgggaggaga tctatgtgtg cgccattgaa atggttaagg tgattctcga gttctttttt      300

gagtttaaga atccctctat gctctacctt gccacaggac accgggtgca gtggctgcgc      360

tatgcagagt ggctgctcac ttgtcctgtc atccttatcc acctgagcaa cctcaccggc      420

ctgagcaacg actacagcag gagaaccatg ggactccttg tctcagacat cgggactatc      480

gtgtgggggg ctaccagcgc catggcaacc ggctatgtta aagtcatctt cttttgtctt      540

ggattgtgct atggcgcgaa cacatttttt cacgccgcca aagcatatat cgagggttat      600

catactgtgc caaagggtcg gtgccgccag gtcgtgaccg gcatggcatg gctgtttttc      660

gtgagctggg gtatgttccc aattctcttc attttggggc ccgaaggttt tggcgtcctg      720

agcgtctatg gctccaccgt aggtcacacg attattgatc tgatgagtaa aaattgttgg      780

gggttgttgg gacactacct gcgcgtcctg atccacgagc acatattgat tcacggagat      840

atccgcaaaa ccaccaaact gaacatcggc ggaacggaga tcgaggtcga gactctcgtc      900

gaagacgaag ccgaggccgg agccgtg                                          927


<210>  19
<211>  309
<212>  PRT
<213>  Chlamydomonas reinhardtii

<400>  19

Met Asp Tyr Gly Gly Ala Leu Ser Ala Val Gly Arg Glu Leu Leu Phe 
1               5                   10                  15      


Val Thr Asn Pro Val Val Val Asn Gly Ser Val Leu Val Pro Glu Asp 
            20                  25                  30          


Gln Cys Tyr Cys Ala Gly Trp Ile Glu Ser Arg Gly Thr Asn Gly Ala 
        35                  40                  45              


Gln Thr Ala Ser Asn Val Leu Gln Trp Leu Ala Ala Gly Phe Ser Ile 
    50                  55                  60                  


Leu Leu Leu Met Phe Tyr Ala Tyr Gln Thr Trp Lys Ser Thr Cys Gly 
65                  70                  75                  80  


Trp Glu Glu Ile Tyr Val Cys Ala Ile Glu Met Val Lys Val Ile Leu 
                85                  90                  95      


Glu Phe Phe Phe Glu Phe Lys Asn Pro Ser Met Leu Tyr Leu Ala Thr 
            100                 105                 110         


Gly His Arg Val Gln Trp Leu Arg Tyr Ala Glu Trp Leu Leu Thr Cys 
        115                 120                 125             


Pro Val Ile Leu Ile His Leu Ser Asn Leu Thr Gly Leu Ser Asn Asp 
    130                 135                 140                 


Tyr Ser Arg Arg Thr Met Gly Leu Leu Val Ser Asp Ile Gly Thr Ile 
145                 150                 155                 160 


Val Trp Gly Ala Thr Ser Ala Met Ala Thr Gly Tyr Val Lys Val Ile 
                165                 170                 175     


Phe Phe Cys Leu Gly Leu Cys Tyr Gly Ala Asn Thr Phe Phe His Ala 
            180                 185                 190         


Ala Lys Ala Tyr Ile Glu Gly Tyr His Thr Val Pro Lys Gly Arg Cys 
        195                 200                 205             


Arg Gln Val Val Thr Gly Met Ala Trp Leu Phe Phe Val Ser Trp Gly 
    210                 215                 220                 


Met Phe Pro Ile Leu Phe Ile Leu Gly Pro Glu Gly Phe Gly Val Leu 
225                 230                 235                 240 


Ser Val Tyr Gly Ser Thr Val Gly His Thr Ile Ile Asp Leu Met Ser 
                245                 250                 255     


Lys Asn Cys Trp Gly Leu Leu Gly His Tyr Leu Arg Val Leu Ile His 
            260                 265                 270         


Glu His Ile Leu Ile His Gly Asp Ile Arg Lys Thr Thr Lys Leu Asn 
        275                 280                 285             


Ile Gly Gly Thr Glu Ile Glu Val Glu Thr Leu Val Glu Asp Glu Ala 
    290                 295                 300                 


Glu Ala Gly Ala Val 
305                 


<210>  20
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Oligonucleotide

<400>  20
gtcccgtgca cgctgctcct gctgttggca gccgccctgg ctccgactca gacgcgggcc       60


<210>  21
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  21

Met Val Pro Cys Thr Leu Leu Leu Leu Leu Ala Ala Ala Leu Ala Pro 
1               5                   10                  15      


Thr Gln Thr Arg Ala 
            20      


<210>  22
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  22
ttctgctacg agaatgaagt g                                                 21


<210>  23
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  23

Phe Cys Tyr Glu Asn Glu Val 
1               5           


<210>  24
<211>  60
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide

<400>  24
aaatccagaa ttacttctga aggggagtat atccctctgg atcaaataga catcaatgtt       60


<210>  25
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic polypeptide

<400>  25

Lys Ser Arg Ile Thr Ser Glu Gly Glu Tyr Ile Pro Leu Asp Gln Ile 
1               5                   10                  15      


Asp Ile Asn Val 
            20  


