
                                SEQUENCE LISTING

<110> Berger, Allison
      Chattopadhyay, Nibedita
      Koenig, Erik M.
      Millennium Pharmaceuticals, Inc.

<120> BIOMARKERS OF RESPONSE TO PROTEASOME
  INHIBITORS

<130> MPI11-015P2RNWOM

<150> US 61/558474        
<151> 2011-11-11  

<150> US 61/721818        
<151> 2012-11-02  

<160> 9

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 5312
<212> DNA
<213> Homo sapiens

<400> 1
ggccgcggcg gcggaggcag cagcggcggc ggcagtggcg gcggcgaagg tggcggcggc 60
tcggccagta ctcccggccc ccgccatttc ggactgggag cgagcgcggc gcaggcactg 120
aaggcggcgg cggggccaga ggctcagcgg ctcccaggtg cgggagagag gcctgctgaa 180
aatgactgaa tataaacttg tggtagttgg agctggtggc gtaggcaaga gtgccttgac 240
gatacagcta attcagaatc attttgtgga cgaatatgat ccaacaatag aggattccta 300
caggaagcaa gtagtaattg atggagaaac ctgtctcttg gatattctcg acacagcagg 360
tcaagaggag tacagtgcaa tgagggacca gtacatgagg actggggagg gctttctttg 420
tgtatttgcc ataaataata ctaaatcatt tgaagatatt caccattata gagaacaaat 480
taaaagagtt aaggactctg aagatgtacc tatggtccta gtaggaaata aatgtgattt 540
gccttctaga acagtagaca caaaacaggc tcaggactta gcaagaagtt atggaattcc 600
ttttattgaa acatcagcaa agacaagaca gggtgttgat gatgccttct atacattagt 660
tcgagaaatt cgaaaacata aagaaaagat gagcaaagat ggtaaaaaga agaaaaagaa 720
gtcaaagaca aagtgtgtaa ttatgtaaat acaatttgta cttttttctt aaggcatact 780
agtacaagtg gtaatttttg tacattacac taaattatta gcatttgttt tagcattacc 840
taattttttt cctgctccat gcagactgtt agcttttacc ttaaatgctt attttaaaat 900
gacagtggaa gttttttttt cctctaagtg ccagtattcc cagagttttg gtttttgaac 960
tagcaatgcc tgtgaaaaag aaactgaata cctaagattt ctgtcttggg gtttttggtg 1020
catgcagttg attacttctt atttttctta ccaattgtga atgttggtgt gaaacaaatt 1080
aatgaagctt ttgaatcatc cctattctgt gttttatcta gtcacataaa tggattaatt 1140
actaatttca gttgagacct tctaattggt ttttactgaa acattgaggg aacacaaatt 1200
tatgggcttc ctgatgatga ttcttctagg catcatgtcc tatagtttgt catccctgat 1260
gaatgtaaag ttacactgtt cacaaaggtt ttgtctcctt tccactgcta ttagtcatgg 1320
tcactctccc caaaatatta tattttttct ataaaaagaa aaaaatggaa aaaaattaca 1380
aggcaatgga aactattata aggccatttc cttttcacat tagataaatt actataaaga 1440
ctcctaatag cttttcctgt taaggcagac ccagtatgaa atggggatta ttatagcaac 1500
cattttgggg ctatatttac atgctactaa atttttataa taattgaaaa gattttaaca 1560
agtataaaaa attctcatag gaattaaatg tagtctccct gtgtcagact gctctttcat 1620
agtataactt taaatctttt cttcaacttg agtctttgaa gatagtttta attctgcttg 1680
tgacattaaa agattatttg ggccagttat agcttattag gtgttgaaga gaccaaggtt 1740
gcaaggccag gccctgtgtg aacctttgag ctttcataga gagtttcaca gcatggactg 1800
tgtccccacg gtcatccagt gttgtcatgc attggttagt caaaatgggg agggactagg 1860
gcagtttgga tagctcaaca agatacaatc tcactctgtg gtggtcctgc tgacaaatca 1920
agagcattgc ttttgtttct taagaaaaca aactcttttt taaaaattac ttttaaatat 1980
taactcaaaa gttgagattt tggggtggtg gtgtgccaag acattaattt tttttttaaa 2040
caatgaagtg aaaaagtttt acaatctcta ggtttggcta gttctcttaa cactggttaa 2100
attaacattg cataaacact tttcaagtct gatccatatt taataatgct ttaaaataaa 2160
aataaaaaca atccttttga taaatttaaa atgttactta ttttaaaata aatgaagtga 2220
gatggcatgg tgaggtgaaa gtatcactgg actaggaaga aggtgactta ggttctagat 2280
aggtgtcttt taggactctg attttgagga catcacttac tatccatttc ttcatgttaa 2340
aagaagtcat ctcaaactct tagttttttt tttttacaac tatgtaattt atattccatt 2400
tacataagga tacacttatt tgtcaagctc agcacaatct gtaaattttt aacctatgtt 2460
acaccatctt cagtgccagt cttgggcaaa attgtgcaag aggtgaagtt tatatttgaa 2520
tatccattct cgttttagga ctcttcttcc atattagtgt catcttgcct ccctaccttc 2580
cacatgcccc atgacttgat gcagttttaa tacttgtaat tcccctaacc ataagattta 2640
ctgctgctgt ggatatctcc atgaagtttt cccactgagt cacatcagaa atgccctaca 2700
tcttatttcc tcagggctca agagaatctg acagatacca taaagggatt tgacctaatc 2760
actaattttc aggtggtggc tgatgctttg aacatctctt tgctgcccaa tccattagcg 2820
acagtaggat ttttcaaacc tggtatgaat agacagaacc ctatccagtg gaaggagaat 2880
ttaataaaga tagtgctgaa agaattcctt aggtaatcta taactaggac tactcctggt 2940
aacagtaata cattccattg ttttagtaac cagaaatctt catgcaatga aaaatacttt 3000
aattcatgaa gcttactttt tttttttggt gtcagagtct cgctcttgtc acccaggctg 3060
gaatgcagtg gcgccatctc agctcactgc aacctccatc tcccaggttc aagcgattct 3120
cgtgcctcgg cctcctgagt agctgggatt acaggcgtgt gccactacac tcaactaatt 3180
tttgtatttt taggagagac ggggtttcac cctgttggcc aggctggtct cgaactcctg 3240
acctcaagtg attcacccac cttggcctca taaacctgtt ttgcagaact catttattca 3300
gcaaatattt attgagtgcc taccagatgc cagtcaccgc acaaggcact gggtatatgg 3360
tatccccaaa caagagacat aatcccggtc cttaggtagt gctagtgtgg tctgtaatat 3420
cttactaagg cctttggtat acgacccaga gataacacga tgcgtatttt agttttgcaa 3480
agaaggggtt tggtctctgt gccagctcta taattgtttt gctacgattc cactgaaact 3540
cttcgatcaa gctactttat gtaaatcact tcattgtttt aaaggaataa acttgattat 3600
attgtttttt tatttggcat aactgtgatt cttttaggac aattactgta cacattaagg 3660
tgtatgtcag atattcatat tgacccaaat gtgtaatatt ccagttttct ctgcataagt 3720
aattaaaata tacttaaaaa ttaatagttt tatctgggta caaataaaca ggtgcctgaa 3780
ctagttcaca gacaaggaaa cttctatgta aaaatcacta tgatttctga attgctatgt 3840
gaaactacag atctttggaa cactgtttag gtagggtgtt aagacttaca cagtacctcg 3900
tttctacaca gagaaagaaa tggccatact tcaggaactg cagtgcttat gaggggatat 3960
ttaggcctct tgaatttttg atgtagatgg gcattttttt aaggtagtgg ttaattacct 4020
ttatgtgaac tttgaatggt ttaacaaaag atttgttttt gtagagattt taaaggggga 4080
gaattctaga aataaatgtt acctaattat tacagcctta aagacaaaaa tccttgttga 4140
agttttttta aaaaaagcta aattacatag acttaggcat taacatgttt gtggaagaat 4200
atagcagacg tatattgtat catttgagtg aatgttccca agtaggcatt ctaggctcta 4260
tttaactgag tcacactgca taggaattta gaacctaact tttataggtt atcaaaactg 4320
ttgtcaccat tgcacaattt tgtcctaata tatacataga aactttgtgg ggcatgttaa 4380
gttacagttt gcacaagttc atctcatttg tattccattg attttttttt tcttctaaac 4440
attttttctt caaacagtat ataacttttt ttaggggatt tttttttaga cagcaaaaac 4500
tatctgaaga tttccatttg tcaaaaagta atgatttctt gataattgtg tagtaatgtt 4560
ttttagaacc cagcagttac cttaaagctg aatttatatt tagtaacttc tgtgttaata 4620
ctggatagca tgaattctgc attgagaaac tgaatagctg tcataaaatg aaactttctt 4680
tctaaagaaa gatactcaca tgagttcttg aagaatagtc ataactagat taagatctgt 4740
gttttagttt aatagtttga agtgcctgtt tgggataatg ataggtaatt tagatgaatt 4800
taggggaaaa aaaagttatc tgcagatatg ttgagggccc atctctcccc ccacaccccc 4860
acagagctaa ctgggttaca gtgttttatc cgaaagtttc caattccact gtcttgtgtt 4920
ttcatgttga aaatactttt gcatttttcc tttgagtgcc aatttcttac tagtactatt 4980
tcttaatgta acatgtttac ctggaatgta ttttaactat ttttgtatag tgtaaactga 5040
aacatgcaca ttttgtacat tgtgctttct tttgtgggac atatgcagtg tgatccagtt 5100
gttttccatc atttggttgc gctgacctag gaatgttggt catatcaaac attaaaaatg 5160
accactcttt taattgaaat taacttttaa atgtttatag gagtatgtgc tgtgaagtga 5220
tctaaaattt gtaatatttt tgtcatgaac tgtactactc ctaattattg taatgtaata 5280
aaaatagtta cagtgacaaa aaaaaaaaaa aa                               5312



<210> 2
<211> 567
<212> DNA
<213> Homo sapiens

<400> 2
atgactgaat ataaacttgt ggtagttgga gctggtggcg taggcaagag tgccttgacg 60
atacagctaa ttcagaatca ttttgtggac gaatatgatc caacaataga ggattcctac 120
aggaagcaag tagtaattga tggagaaacc tgtctcttgg atattctcga cacagcaggt 180
caagaggagt acagtgcaat gagggaccag tacatgagga ctggggaggg ctttctttgt 240
gtatttgcca taaataatac taaatcattt gaagatattc accattatag agaacaaatt 300
aaaagagtta aggactctga agatgtacct atggtcctag taggaaataa atgtgatttg 360
ccttctagaa cagtagacac aaaacaggct caggacttag caagaagtta tggaattcct 420
tttattgaaa catcagcaaa gacaagacag ggtgttgatg atgccttcta tacattagtt 480
cgagaaattc gaaaacataa agaaaagatg agcaaagatg gtaaaaagaa gaaaaagaag 540
tcaaagacaa agtgtgtaat tatgtaa                                     567

<210> 3
<211> 188
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly
        35                  40                  45              
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr
    50                  55                  60                  
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys
65                  70                  75                  80  
Val Phe Ala Ile Asn Asn Thr Lys Ser Phe Glu Asp Ile His His Tyr
                85                  90                  95      
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Glu Asp Val Pro Met Val
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Pro Ser Arg Thr Val Asp Thr Lys
        115                 120                 125             
Gln Ala Gln Asp Leu Ala Arg Ser Tyr Gly Ile Pro Phe Ile Glu Thr
    130                 135                 140                 
Ser Ala Lys Thr Arg Gln Gly Val Asp Asp Ala Phe Tyr Thr Leu Val
145                 150                 155                 160 
Arg Glu Ile Arg Lys His Lys Glu Lys Met Ser Lys Asp Gly Lys Lys
                165                 170                 175     
Lys Lys Lys Lys Ser Lys Thr Lys Cys Val Ile Met
            180                 185             


<210> 4
<211> 4454
<212> DNA
<213> Homo Sapiens

<400> 4
gaaacgtccc gtgtgggagg ggcgggtctg ggtgcggcct gccgcatgac tcgtggttcg 60
gaggcccacg tggccggggc ggggactcag gcgcctgggg cgccgactga ttacgtagcg 120
ggcggggccg gaagtgccgc tccttggtgg gggctgttca tggcggttcc ggggtctcca 180
acatttttcc cggctgtggt cctaaatctg tccaaagcag aggcagtgga gcttgaggtt 240
cttgctggtg tgaaatgact gagtacaaac tggtggtggt tggagcaggt ggtgttggga 300
aaagcgcact gacaatccag ctaatccaga accactttgt agatgaatat gatcccacca 360
tagaggattc ttacagaaaa caagtggtta tagatggtga aacctgtttg ttggacatac 420
tggatacagc tggacaagaa gagtacagtg ccatgagaga ccaatacatg aggacaggcg 480
aaggcttcct ctgtgtattt gccatcaata atagcaagtc atttgcggat attaacctct 540
acagggagca gattaagcga gtaaaagact cggatgatgt acctatggtg ctagtgggaa 600
acaagtgtga tttgccaaca aggacagttg atacaaaaca agcccacgaa ctggccaaga 660
gttacgggat tccattcatt gaaacctcag ccaagaccag acagggtgtt gaagatgctt 720
tttacacact ggtaagagaa atacgccagt accgaatgaa aaaactcaac agcagtgatg 780
atgggactca gggttgtatg ggattgccat gtgtggtgat gtaacaagat acttttaaag 840
ttttgtcaga aaagagccac tttcaagctg cactgacacc ctggtcctga cttccctgga 900
ggagaagtat tcctgttgct gtcttcagtc tcacagagaa gctcctgcta cttccccagc 960
tctcagtagt ttagtacaat aatctctatt tgagaagttc tcagaataac tacctcctca 1020
cttggctgtc tgaccagaga atgcacctct tgttactccc tgttattttt ctgccctggg 1080
ttcttccaca gcacaaacac acctctgcca ccccaggttt ttcatctgaa aagcagttca 1140
tgtctgaaac agagaaccaa accgcaaacg tgaaattcta ttgaaaacag tgtcttgagc 1200
tctaaagtag caactgctgg tgattttttt tttcttttta ctgttgaact tagaactatg 1260
ctaatttttg gagaaatgtc ataaattact gttttgccaa gaatatagtt attattgctg 1320
tttggtttgt ttataatgtt atcggctcta ttctctaaac tggcatctgc tctagattca 1380
taaatacaaa aatgaatact gaattttgag tctatcctag tcttcacaac tttgacgtaa 1440
ttaaatccaa ctttcacagt gaagtgcctt tttcctagaa gtggtttgta gacttccttt 1500
ataatatttc agtggaatag atgtctcaaa aatccttatg catgaaatga atgtctgaga 1560
tacgtctgtg acttatctac cattgaagga aagctatatc tatttgagag cagatgccat 1620
tttgtacatg tatgaaattg gttttccaga ggcctgtttt ggggctttcc caggagaaag 1680
atgaaactga aagcacatga ataatttcac ttaataattt ttacctaatc tccacttttt 1740
tcataggtta ctacctatac aatgtatgta atttgtttcc cctagcttac tgataaacct 1800
aatattcaat gaacttccat ttgtattcaa atttgtgtca taccagaaag ctctacattt 1860
gcagatgttc aaatattgta aaactttggt gcattgttat ttaatagctg tgatcagtga 1920
ttttcaaacc tcaaatatag tatattaaca aattacattt tcactgtata tcatggtatc 1980
ttaatgatgt atataattgc cttcaatccc cttctcaccc caccctctac agcttccccc 2040
acagcaatag gggcttgatt atttcagttg agtaaagcat ggtgctaatg gaccagggtc 2100
acagtttcaa aacttgaaca atccagttag catcacagag aaagaaattc ttctgcattt 2160
gctcattgca ccagtaactc cagctagtaa ttttgctagg tagctgcagt tagccctgca 2220
aggaaagaag aggtcagtta gcacaaaccc tttaccatga ctggaaaact cagtatcacg 2280
tatttaaaca tttttttttc ttttagccat gtagaaactc taaattaagc caatattctc 2340
atttgagaat gaggatgtct cagctgagaa acgttttaaa ttctctttat tcataatgtt 2400
ctttgaaggg tttaaaacaa gatgttgata aatctaagct gatgagtttg ctcaaaacag 2460
gaagttgaaa ttgttgagac aggaatggaa aatataatta attgatacct atgaggattt 2520
ggaggcttgg cattttaatt tgcagataat accctggtaa ttctcatgaa aaatagactt 2580
ggataacttt tgataaaaga ctaattccaa aatggccact ttgttcctgt ctttaatatc 2640
taaatactta ctgaggtcct ccatcttcta tattatgaat tttcatttat taagcaaatg 2700
tcatattacc ttgaaattca gaagagaaga aacatatact gtgtccagag tataatgaac 2760
ctgcagagtt gtgcttctta ctgctaattc tgggagcttt cacagtactg tcatcatttg 2820
taaatggaaa ttctgctttt ctgtttctgc tccttctgga gcagtgctac tctgtaattt 2880
tcctgaggct tatcacctca gtcatttctt ttttaaatgt ctgtgactgg cagtgattct 2940
ttttcttaaa aatctattaa atttgatgtc aaattaggga gaaagatagt tactcatctt 3000
gggctcttgt gccaatagcc cttgtatgta tgtacttaga gttttccaag tatgttctaa 3060
gcacagaagt ttctaaatgg ggccaaaatt cagacttgag tatgttcttt gaatacctta 3120
agaagttaca attagccggg catggtggcc cgtgcctgta gtcccagcta cttgagaggc 3180
tgaggcagga gaatcacttc aacccaggag gtggaggtta cagtgagcag agatcgtgcc 3240
actgcactcc agcctgggtg acaagagaga cttgtctcca aaaaaaaagt tacacctagg 3300
tgtgaatttt ggcacaaagg agtgacaaac ttatagttaa aagctgaata acttcagtgt 3360
ggtataaaac gtggttttta ggctatgttt gtgattgctg aaaagaattc tagtttacct 3420
caaaatcctt ctctttcccc aaattaagtg cctggccagc tgtcataaat tacatattcc 3480
ttttggtttt tttaaaggtt acatgttcaa gagtgaaaat aagatgttct gtctgaaggc 3540
taccatgccg gatctgtaaa tgaacctgtt aaatgctgta tttgctccaa cggcttacta 3600
tagaatgtta cttaatacaa tatcatactt attacaattt ttactatagg agtgtaatag 3660
gtaaaattaa tctctatttt agtgggccca tgtttagtct ttcaccatcc tttaaactgc 3720
tgtgaatttt tttgtcatga cttgaaagca aggatagaga aacactttag agatatgtgg 3780
ggttttttta ccattccaga gcttgtgagc ataatcatat ttgctttata tttatagtca 3840
tgaactccta agttggcagc tacaaccaag aaccaaaaaa tggtgcgttc tgcttcttgt 3900
aattcatctc tgctaataaa ttataagaag caaggaaaat tagggaaaat attttatttg 3960
gatggtttct ataaacaagg gactataatt cttgtacatt atttttcatc tttgctgttt 4020
ctttgagcag tctaatgtgc cacacaatta tctaaggtat ttgttttcta taagaattgt 4080
tttaaaagta ttcttgttac cagagtagtt gtattatatt tcaaaacgta agatgatttt 4140
taaaagcctg agtactgacc taagatggaa ttgtatgaac tctgctctgg agggagggga 4200
ggatgtccgt ggaagttgta agacttttat ttttttgtgc catcaaatat aggtaaaaat 4260
aattgtgcaa ttctgctgtt taaacaggaa ctattggcct ccttggccct aaatggaagg 4320
gccgatattt taagttgatt attttattgt aaattaatcc aacctagttc tttttaattt 4380
ggttgaatgt tttttcttgt taaatgatgt ttaaaaaata aaaactggaa gttcttggct 4440
tagtcataat tctt                                                   4454

<210> 5
<211> 570
<212> DNA
<213> Homo sapiens

<400> 5
atgactgagt acaaactggt ggtggttgga gcaggtggtg ttgggaaaag cgcactgaca 60
atccagctaa tccagaacca ctttgtagat gaatatgatc ccaccataga ggattcttac 120
agaaaacaag tggttataga tggtgaaacc tgtttgttgg acatactgga tacagctgga 180
caagaagagt acagtgccat gagagaccaa tacatgagga caggcgaagg cttcctctgt 240
gtatttgcca tcaataatag caagtcattt gcggatatta acctctacag ggagcagatt 300
aagcgagtaa aagactcgga tgatgtacct atggtgctag tgggaaacaa gtgtgatttg 360
ccaacaagga cagttgatac aaaacaagcc cacgaactgg ccaagagtta cgggattcca 420
ttcattgaaa cctcagccaa gaccagacag ggtgttgaag atgcttttta cacactggta 480
agagaaatac gccagtaccg aatgaaaaaa ctcaacagca gtgatgatgg gactcagggt 540
tgtatgggat tgccatgtgt ggtgatgtaa                                  570

<210> 6
<211> 189
<212> PRT
<213> Homo sapiens

<400> 6
Met Thr Glu Tyr Lys Leu Val Val Val Gly Ala Gly Gly Val Gly Lys
 1               5                  10                  15      
Ser Ala Leu Thr Ile Gln Leu Ile Gln Asn His Phe Val Asp Glu Tyr
            20                  25                  30          
Asp Pro Thr Ile Glu Asp Ser Tyr Arg Lys Gln Val Val Ile Asp Gly
        35                  40                  45              
Glu Thr Cys Leu Leu Asp Ile Leu Asp Thr Ala Gly Gln Glu Glu Tyr
    50                  55                  60                  
Ser Ala Met Arg Asp Gln Tyr Met Arg Thr Gly Glu Gly Phe Leu Cys
65                  70                  75                  80  
Val Phe Ala Ile Asn Asn Ser Lys Ser Phe Ala Asp Ile Asn Leu Tyr
                85                  90                  95      
Arg Glu Gln Ile Lys Arg Val Lys Asp Ser Asp Asp Val Pro Met Val
            100                 105                 110         
Leu Val Gly Asn Lys Cys Asp Leu Pro Thr Arg Thr Val Asp Thr Lys
        115                 120                 125             
Gln Ala His Glu Leu Ala Lys Ser Tyr Gly Ile Pro Phe Ile Glu Thr
    130                 135                 140                 
Ser Ala Lys Thr Arg Gln Gly Val Glu Asp Ala Phe Tyr Thr Leu Val
145                 150                 155                 160 
Arg Glu Ile Arg Gln Tyr Arg Met Lys Lys Leu Asn Ser Ser Asp Asp
                165                 170                 175     
Gly Thr Gln Gly Cys Met Gly Leu Pro Cys Val Val Met
            180                 185                 


<210> 7
<211> 3159
<212> DNA
<213> Homo sapiens

<400> 7
cgctccacca gatccgcggg agccccactg ctctccgggt ccttggcttg tggctgtggg 60
tcccatcggg cccgccctcg cacgtcactc cgggaccccc gcggcctccg caggttctgc 120
gctccaggcc ggagtcagag actccaggat cggttctttc atcttcgccg cccctgcgcg 180
tccagctctt ctaagacgag atgccgtcgg gcttccaaca gataggctcc gaagatgggg 240
aaccccctca gcagcgagtg actgggaccc tggtccttgc tgtgttctct gcggtgcttg 300
gctccctgca gtttgggtac aacattgggg tcatcaatgc ccctcagaag gtgattgaac 360
agagctacaa tgagacgtgg ctggggaggc aggggcctga gggacccagc tccatccctc 420
caggcaccct caccaccctc tgggccctct ccgtggccat cttttccgtg ggcggcatga 480
tttcctcctt cctcattggt atcatctctc agtggcttgg aaggaaaagg gccatgctgg 540
tcaacaatgt cctggcggtg ctggggggca gcctcatggg cctggccaat gctgctgcct 600
cctatgaaat gctcatcctt ggacgattcc tcattggcgc ctactcaggg ctgacatcag 660
ggctggtgcc catgtacgtg ggggagattg ctcccactca cctgcggggc gccctgggga 720
cgctcaacca actggccatt gttatcggca ttctgatcgc ccaggtgctg ggcttggagt 780
ccctcctggg cactgccagc ctgtggccac tgctcctggg cctcacagtg ctacctgccc 840
tcctgcagct ggtcctgctg cccttctgtc ccgagagccc ccgctacctc tacatcatcc 900
agaatctcga ggggcctgcc agaaagagtc tgaagcgcct gacaggctgg gccgatgttt 960
ctggagtgct ggctgagctg aaggatgaga agcggaagct ggagcgtgag cggccactgt 1020
ccctgctcca gctcctgggc agccgtaccc accggcagcc cctgatcatt gcggtcgtgc 1080
tgcagctgag ccagcagctc tctggcatca atgctgtttt ctattattcg accagcatct 1140
tcgagacagc aggggtaggc cagcctgcct atgccaccat aggagctggt gtggtcaaca 1200
cagtcttcac cttggtctcg gtgttgttgg tggagcgggc ggggcgccgg acgctccatc 1260
tcctgggcct ggcgggcatg tgtggctgtg ccatcctgat gactgtggct ctgctcctgc 1320
tggagcgagt tccagccatg agctacgtct ccattgtggc catctttggc ttcgtggcat 1380
tttttgagat tggccctggc cccattcctt ggttcatcgt ggccgagctc ttcagccagg 1440
gaccccgccc ggcagccatg gctgtggctg gtttctccaa ctggacgagc aacttcatca 1500
ttggcatggg tttccagtat gttgcggagg ctatggggcc ctacgtcttc cttctatttg 1560
cggtcctcct gctgggcttc ttcatcttca ccttcttaag agtacctgaa actcgaggcc 1620
ggacgtttga ccagatctca gctgccttcc accggacacc ctctctttta gagcaggagg 1680
tgaaacccag cacagaactt gagtatttag ggccagatga gaacgactga ggggccaggc 1740
aggggtggga gagccagctc tctctacccg gcccagagac cccttccttt cctctgcagc 1800
actttaaccc tctcttccct attatttccg ggtggaaaag aatccctgca gcctggtaga 1860
attgggaagc tgggggaagg gtggtctgag caccccctca ttcccctcgt gtgactctct 1920
tggattattt atgtgttgtg gtttggccgt ggccatcagg gtgggccact ctcccctccc 1980
tcttccttcc cccatcccct ttcctcccca ccttccccag actcagctcc agaatacctt 2040
cttcgctgct agagaagggg gattggaggg aagacaggtc tagactttct cagtgggaca 2100
aaccagagca gagagcagga caggagacaa gaaatccagt ttcccaccac cttggactcc 2160
tcccacaatc tgggactttc actgaattct tgccacgcag actctgggca aaggggtttt 2220
tttttttttt tttttttttt tttttgagac agtctcgctc tgtcgcccag gctcgagtgc 2280
agtggcgtga tcttgcttca ctgcaagctg tctcccaggt tcacgccatt ctcctgcctc 2340
agcctccgga gtagctggga ctacaggcgc atgccaccac acctggctaa tttattttgt 2400
atttttagta tatacgcggt ttcaccatgt tagccagaat ggtctcgatc tcctgacctc 2460
gtgatctgcc tgcctcagcc tcccaaagtg ctgggattac aggcgtgagc caccgcgcct 2520
ggcgaaggga gttctctctt gacccctgca gggaaaagga ctcacctccc tcactgcagg 2580
ctcagccttc cagggcaaga gggaacagga aagtatgtgc ccatgtgtgg caagatggaa 2640
ggacggcagg ctcccgcctc taggcttggg gctctacccc gatggtttcc caaggctgcc 2700
aagaaggagc cctaactttc ttcctctccc ttcctggaag ggtgctgcat ccacaggctt 2760
ttgaccaact aaggcaaaga ggggatttga aaggctgcct ggaaacactg ggctgggagg 2820
agcctttgga tatttttata tacgtttgaa aaggggattg agagaagaaa ccaaaggtcg 2880
gttgtactaa atgtatatat atagatactt ctataaagtc actgctgaag acaagcatcc 2940
tattgtggag gtacttgagg atgggctgag acagggacca taactcttca cccctcttcc 3000
tccctctgtc ctgcctcagc tcaaggcctc agaatcttct ggatgccatt gctcatgccc 3060
ctactcacat ttctactcgt tgctttatta atagtaaatg ctcaataaat tgtagctgcc 3120
agtgccgggc attgctcttg gcatttgcaa aaaaaaaaa                        3159

<210> 8
<211> 1530
<212> DNA
<213> Homo sapiens

<400> 8
atgccgtcgg gcttccaaca gataggctcc gaagatgggg aaccccctca gcagcgagtg 60
actgggaccc tggtccttgc tgtgttctct gcggtgcttg gctccctgca gtttgggtac 120
aacattgggg tcatcaatgc ccctcagaag gtgattgaac agagctacaa tgagacgtgg 180
ctggggaggc aggggcctga gggacccagc tccatccctc caggcaccct caccaccctc 240
tgggccctct ccgtggccat cttttccgtg ggcggcatga tttcctcctt cctcattggt 300
atcatctctc agtggcttgg aaggaaaagg gccatgctgg tcaacaatgt cctggcggtg 360
ctggggggca gcctcatggg cctggccaat gctgctgcct cctatgaaat gctcatcctt 420
ggacgattcc tcattggcgc ctactcaggg ctgacatcag ggctggtgcc catgtacgtg 480
ggggagattg ctcccactca cctgcggggc gccctgggga cgctcaacca actggccatt 540
gttatcggca ttctgatcgc ccaggtgctg ggcttggagt ccctcctggg cactgccagc 600
ctgtggccac tgctcctggg cctcacagtg ctacctgccc tcctgcagct ggtcctgctg 660
cccttctgtc ccgagagccc ccgctacctc tacatcatcc agaatctcga ggggcctgcc 720
agaaagagtc tgaagcgcct gacaggctgg gccgatgttt ctggagtgct ggctgagctg 780
aaggatgaga agcggaagct ggagcgtgag cggccactgt ccctgctcca gctcctgggc 840
agccgtaccc accggcagcc cctgatcatt gcggtcgtgc tgcagctgag ccagcagctc 900
tctggcatca atgctgtttt ctattattcg accagcatct tcgagacagc aggggtaggc 960
cagcctgcct atgccaccat aggagctggt gtggtcaaca cagtcttcac cttggtctcg 1020
gtgttgttgg tggagcgggc ggggcgccgg acgctccatc tcctgggcct ggcgggcatg 1080
tgtggctgtg ccatcctgat gactgtggct ctgctcctgc tggagcgagt tccagccatg 1140
agctacgtct ccattgtggc catctttggc ttcgtggcat tttttgagat tggccctggc 1200
cccattcctt ggttcatcgt ggccgagctc ttcagccagg gaccccgccc ggcagccatg 1260
gctgtggctg gtttctccaa ctggacgagc aacttcatca ttggcatggg tttccagtat 1320
gttgcggagg ctatggggcc ctacgtcttc cttctatttg cggtcctcct gctgggcttc 1380
ttcatcttca ccttcttaag agtacctgaa actcgaggcc ggacgtttga ccagatctca 1440
gctgccttcc accggacacc ctctctttta gagcaggagg tgaaacccag cacagaactt 1500
gagtatttag ggccagatga gaacgactga                                  1530

<210> 9
<211> 509
<212> PRT
<213> Homo sapiens

<400> 9
Met Pro Ser Gly Phe Gln Gln Ile Gly Ser Glu Asp Gly Glu Pro Pro
 1               5                  10                  15      
Gln Gln Arg Val Thr Gly Thr Leu Val Leu Ala Val Phe Ser Ala Val
            20                  25                  30          
Leu Gly Ser Leu Gln Phe Gly Tyr Asn Ile Gly Val Ile Asn Ala Pro
        35                  40                  45              
Gln Lys Val Ile Glu Gln Ser Tyr Asn Glu Thr Trp Leu Gly Arg Gln
    50                  55                  60                  
Gly Pro Glu Gly Pro Ser Ser Ile Pro Pro Gly Thr Leu Thr Thr Leu
65                  70                  75                  80  
Trp Ala Leu Ser Val Ala Ile Phe Ser Val Gly Gly Met Ile Ser Ser
                85                  90                  95      
Phe Leu Ile Gly Ile Ile Ser Gln Trp Leu Gly Arg Lys Arg Ala Met
            100                 105                 110         
Leu Val Asn Asn Val Leu Ala Val Leu Gly Gly Ser Leu Met Gly Leu
        115                 120                 125             
Ala Asn Ala Ala Ala Ser Tyr Glu Met Leu Ile Leu Gly Arg Phe Leu
    130                 135                 140                 
Ile Gly Ala Tyr Ser Gly Leu Thr Ser Gly Leu Val Pro Met Tyr Val
145                 150                 155                 160 
Gly Glu Ile Ala Pro Thr His Leu Arg Gly Ala Leu Gly Thr Leu Asn
                165                 170                 175     
Gln Leu Ala Ile Val Ile Gly Ile Leu Ile Ala Gln Val Leu Gly Leu
            180                 185                 190         
Glu Ser Leu Leu Gly Thr Ala Ser Leu Trp Pro Leu Leu Leu Gly Leu
        195                 200                 205             
Thr Val Leu Pro Ala Leu Leu Gln Leu Val Leu Leu Pro Phe Cys Pro
    210                 215                 220                 
Glu Ser Pro Arg Tyr Leu Tyr Ile Ile Gln Asn Leu Glu Gly Pro Ala
225                 230                 235                 240 
Arg Lys Ser Leu Lys Arg Leu Thr Gly Trp Ala Asp Val Ser Gly Val
                245                 250                 255     
Leu Ala Glu Leu Lys Asp Glu Lys Arg Lys Leu Glu Arg Glu Arg Pro
            260                 265                 270         
Leu Ser Leu Leu Gln Leu Leu Gly Ser Arg Thr His Arg Gln Pro Leu
        275                 280                 285             
Ile Ile Ala Val Val Leu Gln Leu Ser Gln Gln Leu Ser Gly Ile Asn
    290                 295                 300                 
Ala Val Phe Tyr Tyr Ser Thr Ser Ile Phe Glu Thr Ala Gly Val Gly
305                 310                 315                 320 
Gln Pro Ala Tyr Ala Thr Ile Gly Ala Gly Val Val Asn Thr Val Phe
                325                 330                 335     
Thr Leu Val Ser Val Leu Leu Val Glu Arg Ala Gly Arg Arg Thr Leu
            340                 345                 350         
His Leu Leu Gly Leu Ala Gly Met Cys Gly Cys Ala Ile Leu Met Thr
        355                 360                 365             
Val Ala Leu Leu Leu Leu Glu Arg Val Pro Ala Met Ser Tyr Val Ser
    370                 375                 380                 
Ile Val Ala Ile Phe Gly Phe Val Ala Phe Phe Glu Ile Gly Pro Gly
385                 390                 395                 400 
Pro Ile Pro Trp Phe Ile Val Ala Glu Leu Phe Ser Gln Gly Pro Arg
                405                 410                 415     
Pro Ala Ala Met Ala Val Ala Gly Phe Ser Asn Trp Thr Ser Asn Phe
            420                 425                 430         
Ile Ile Gly Met Gly Phe Gln Tyr Val Ala Glu Ala Met Gly Pro Tyr
        435                 440                 445             
Val Phe Leu Leu Phe Ala Val Leu Leu Leu Gly Phe Phe Ile Phe Thr
    450                 455                 460                 
Phe Leu Arg Val Pro Glu Thr Arg Gly Arg Thr Phe Asp Gln Ile Ser
465                 470                 475                 480 
Ala Ala Phe His Arg Thr Pro Ser Leu Leu Glu Gln Glu Val Lys Pro
                485                 490                 495     
Ser Thr Glu Leu Glu Tyr Leu Gly Pro Asp Glu Asn Asp
            500                 505                 

