                         SEQUENCE LISTING

<110>  MedImmune, LLC
 
<120>  MULTISPECIFIC AND MULTIVALENT BINDING PROTEINS AND USES THEREOF

<130>  AEMS-115WO1

<160>  70    

<170>  PatentIn version 3.5

<210>  1
<211>  294
<212>  DNA
<213>  Homo sapiens

<400>  1
gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg       60

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc      120

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      180

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc      240

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agtt            294


<210>  2
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 
1               5                   10                  15      


Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 
            20                  25                  30          


Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 
        35                  40                  45              


Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 
    50                  55                  60                  


Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 
65                  70                  75                  80  


Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 
                85                  90                  95      


Arg Val 
        


<210>  3
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  3
gagcccaaat cttgtgacaa aact                                              24


<210>  4
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  4

Glu Pro Lys Ser Cys Asp Lys Thr 
1               5               


<210>  5
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  5
gagcccaaat cttgtggaaa aact                                              24


<210>  6
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  6

Glu Pro Lys Ser Cys Gly Lys Thr 
1               5               


<210>  7
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  7
ggcggagggg gatccggcgg agggggctct                                        30


<210>  8
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  8

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210>  9
<211>  45
<212>  DNA
<213>  Homo sapiens

<400>  9
gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gccca                       45


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  11
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  11
gagcccaaat ctgtagacaa aactcacaca tgcccaccgt gccca                       45


<210>  12
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  12

Glu Pro Lys Ser Val Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  13
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  13
tgcccaccgt gccca                                                        15


<210>  14
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  14

Cys Pro Pro Cys Pro 
1               5   


<210>  15
<211>  330
<212>  DNA
<213>  Homo sapiens

<400>  15
gcacctgaac tcctgggggg accgtcagtc ttcctcttcc ccccaaaacc caaggacacc       60

ctcatgatct cccggacccc tgaggtcaca tgcgtggtgg tggacgtgag ccacgaagac      120

cctgaggtca agttcaactg gtacgtggac ggcgtggagg tgcataatgc caagacaaag      180

ccgcgggagg agcagtacaa cagcacgtac cgtgtggtca gcgtcctcac cgtcctgcac      240

caggactggc tgaatggcaa ggagtacaag tgcaaggtct ccaacaaagc cctcccagcc      300

cccatcgaga aaaccatctc caaagccaaa                                       330


<210>  16
<211>  110
<212>  PRT
<213>  Homo sapiens

<400>  16

Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
1               5                   10                  15      


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            20                  25                  30          


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        35                  40                  45              


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    50                  55                  60                  


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
65                  70                  75                  80  


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                85                  90                  95      


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            100                 105                 110 


<210>  17
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  17
gggcagcccc gagaaccaca ggtctacacc ctgcccccat cccgggagga gatgaccaag       60

aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag      120

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      180

gacggctcct tcttcctcta tagcaagctc accgtggaca agagcaggtg gcagcagggg      240

aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc      300

ttaagcctgt ctccgggtaa a                                                321


<210>  18
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
1               5                   10                  15      


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  19
<211>  648
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  19
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgcc aggccagcca ggacatcagc aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaagctgct gatctacgac gccagcaacc tggagacagg cgtgcccagc      180

agattcagcg gcagcggctc cggcaccgac ttcaccttca ccatcagcag cctccagccc      240

gaggatatcg ccacctactt ttgccagcac ttcgaccacc tgcccctggc ctttggcggc      300

ggaacaaagg tggagatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttagtga                   648


<210>  20
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  20

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  21
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  21

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Gln Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Asp Ala Ser Asn Leu Glu Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Ile Ala Thr Tyr Phe Cys Gln His Phe Asp His Leu Pro Leu 
                85                  90                  95      


Ala Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  22
<211>  2148
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  22
caggtgcagc tccaggagag cggccctggc ctggtgaagc ccagcgagac actgagcctg       60

acctgcaccg tgtccggcgg cagcgtgtcc agcggcgact actactggac ctggatcaga      120

cagagccccg gcaagggcct ggagtggatc ggccacatct actacagcgg caacaccaac      180

tacaacccca gcctgaagtc cagactgacc atcagcatcg acaccagcaa gacccagttc      240

agcctgaagc tgtccagcgt gacagccgcc gacaccgcca tctactactg cgtgagagac      300

agagtgaccg gcgctttcga catctggggc cagggcacca tggtgaccgt gtccagcgcg      360

tcgaccaagg gacctagcgt gttccctctg gcccccagca gcaagtctac atctggcgga      420

acagccgccc tgggctgcct cgtgaaggac tactttcccg agcccgtgac cgtgtcctgg      480

aacagcggag cactgacaag cggcgtgcac acctttccag ccgtgctgca gagcagcggc      540

ctgtactctc tgagcagcgt cgtgacagtg cccagcagct ctctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagcgggt ggaacccaag      660

agctgcggca aaacaggcgg cggaggatcc ggcggaggcg gctctgatat cgtgatgacc      720

cagagccccc tgagcctgcc tgtgacacct ggcgaacctg ccagcatcag ctgcagatcc      780

agccagagca tcgtgcacag caacggcaac acctacctgc agtggtatct gcagaagccc      840

ggccagagcc ctcagctgct gatctacaag gtgtccaacc ggctgtacgg cgtgcccgac      900

agattttctg gcagcggctc cggcaccgac ttcaccctga agatctcccg ggtggaagcc      960

gaggacgtgg gcgtgtacta ctgttttcaa ggcagccacg tgccctggac cttcggctgt     1020

ggcacaaagg tggaaatcaa gggcggaggg ggatctgggg gcggaggctc tggcggggga     1080

ggaagtgggg gaggcggatc tcaggtgcag ctgcaggaat ctggccctgg cctcgtgaaa     1140

cccagcgaga cactgagcct gacatgcacc gtgtccggct acagcatcac cggcggctac     1200

ctgtggaact ggatcagaca gccccctggc aagtgcctgg aatggatcgg ctacatcagc     1260

tacgacggca ccaacaacta caagccctcc ctgaaggaca gagtgaccat cagccgggac     1320

accagcaaga accagttcag cctgaagctg tccagcgtga cagccgccga taccgccgtg     1380

tactattgcg ccagatacgg ccgggtgttc ttcgactatt ggggccaggg caccctcgtg     1440

actgtgtcat ctgggggagg gggaagcgga ggcggaggaa gttgtcctcc ttgtcctgcc     1500

cccgaactgc tgggcggacc ttccgtgttc ctgttccccc caaagcccaa ggacaccctg     1560

atgatcagcc ggacccccga agtgacctgc gtggtggtgg atgtgtccca cgaggaccct     1620

gaagtgaagt tcaattggta cgtggacggc gtggaagtgc acaacgccaa gaccaagcct     1680

agagaggaac agtacaacag cacctaccgg gtggtgtccg tgctgacagt gctgcaccag     1740

gactggctga acggcaaaga gtacaagtgc aaagtgtcca acaaggccct gcctgccccc     1800

atcgagaaaa ccatcagcaa ggccaaggga cagccccgcg agccccaagt gtataccctg     1860

ccccctagcc gggaagagat gaccaagaat caggtgtccc tgacctgtct cgtgaaaggc     1920

ttctacccca gcgacattgc cgtggaatgg gagagcaacg gccagcccga gaacaattac     1980

aagaccaccc cccctgtgct ggactccgac ggctcattct tcctgtactc caagctgacc     2040

gtggacaaga gccggtggca gcagggcaac gtgttcagct gctccgtgat gcacgaggcc     2100

ctgcacaacc actacaccca gaagtccctg tccctgagcc ccggcaaa                  2148


<210>  23
<211>  716
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  23

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Gly Lys 
    210                 215                 220                 


Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Met Thr 
225                 230                 235                 240 


Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile 
                245                 250                 255     


Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser Asn Gly Asn Thr Tyr 
            260                 265                 270         


Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile 
        275                 280                 285             


Tyr Lys Val Ser Asn Arg Leu Tyr Gly Val Pro Asp Arg Phe Ser Gly 
    290                 295                 300                 


Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala 
305                 310                 315                 320 


Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val Pro Trp 
                325                 330                 335     


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            340                 345                 350         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        355                 360                 365             


Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr 
    370                 375                 380                 


Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Gly Gly Tyr 
385                 390                 395                 400 


Leu Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp Ile 
                405                 410                 415     


Gly Tyr Ile Ser Tyr Asp Gly Thr Asn Asn Tyr Lys Pro Ser Leu Lys 
            420                 425                 430         


Asp Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 
        435                 440                 445             


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
    450                 455                 460                 


Arg Tyr Gly Arg Val Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val 
465                 470                 475                 480 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro 
                485                 490                 495     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            500                 505                 510         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        515                 520                 525             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    530                 535                 540                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
545                 550                 555                 560 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                565                 570                 575     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            580                 585                 590         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        595                 600                 605             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    610                 615                 620                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
625                 630                 635                 640 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                645                 650                 655     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            660                 665                 670         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        675                 680                 685             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    690                 695                 700                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715     


<210>  24
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  24

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 
            20                  25                  30          


Asp Tyr Tyr Trp Thr Trp Ile Arg Gln Ser Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Ile Gly His Ile Tyr Tyr Ser Gly Asn Thr Asn Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Leu Thr Ile Ser Ile Asp Thr Ser Lys Thr Gln Phe 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Ile Tyr Tyr 
                85                  90                  95      


Cys Val Arg Asp Arg Val Thr Gly Ala Phe Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Met Val Thr Val Ser Ser 
        115                 


<210>  25
<211>  249
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  25

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Tyr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val 
    130                 135                 140                 


Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser 
145                 150                 155                 160 


Ile Thr Gly Gly Tyr Leu Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys 
                165                 170                 175     


Cys Leu Glu Trp Ile Gly Tyr Ile Ser Tyr Asp Gly Thr Asn Asn Tyr 
            180                 185                 190         


Lys Pro Ser Leu Lys Asp Arg Val Thr Ile Ser Arg Asp Thr Ser Lys 
        195                 200                 205             


Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala 
    210                 215                 220                 


Val Tyr Tyr Cys Ala Arg Tyr Gly Arg Val Phe Phe Asp Tyr Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  26
<211>  112
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Ile Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu Gln Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Leu Tyr Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly 
                85                  90                  95      


Ser His Val Pro Trp Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


<210>  27
<211>  117
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  27

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Gly Gly 
            20                  25                  30          


Tyr Leu Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Trp 
        35                  40                  45              


Ile Gly Tyr Ile Ser Tyr Asp Gly Thr Asn Asn Tyr Lys Pro Ser Leu 
    50                  55                  60                  


Lys Asp Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Gly Arg Val Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  28
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  28
gacatccaga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga cagagtgacc       60

atcacctgta gcgccagcca ggacatcagc aactacctga actggtatca gcagaagccc      120

ggcaaggccc ccaaggtgct gatctacttc accagctccc tgcacagcgg cgtgcccagc      180

agattttctg gcagcggcag cggcaccgac ttcaccctga ccatcagcag cctgcagccc      240

gaggacttcg ccacctacta ctgccagcag tacagcaccg tgccttggac cttcggccag      300

ggcaccaagg tggaaatcaa gcgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  29
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  29

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  30
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  30

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Gln Asp Ile Ser Asn Tyr 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Leu Ile 
        35                  40                  45              


Tyr Phe Thr Ser Ser Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Ser Thr Val Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  31
<211>  2184
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  31
gaggtgcagc tggtggaaag cggcggagga ctggtgcagc ctggcggcag cctgagactg       60

tcttgtgccg ccagcggcta caccttcacc aactacggca tgaactgggt gcgccaggcc      120

cctggcaagg gactggaatg ggtgggatgg atcaacacct acaccggcga gcccacctac      180

gccgccgact tcaagcggcg gttcaccttc agcctggaca ccagcaagag caccgcctac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc caagtacccc      300

cactactacg gcagcagcca ctggtacttc gacgtgtggg gccagggcac cctggtgaca      360

gtgtccagcg cgtcgaccaa gggacctagc gtgttccctc tggcccccag cagcaagtct      420

acatctggcg gaacagccgc cctgggctgc ctcgtgaagg actactttcc cgagcccgtg      480

accgtgtcct ggaacagcgg agcactgaca agcggcgtgc acacctttcc agccgtgctg      540

cagagcagcg gcctgtactc tctgagcagc gtcgtgacag tgcccagcag ctctctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt ggacaagcgg      660

gtggaaccca agagctgcgg caaaacaggc ggcggaggat ccggcggagg cggatctcag      720

gtgcagctgg tggaaagcgg cgctgaagtg aagaaacctg gggccagcgt gaaggtgtcc      780

tgcaaggcca gcggctacac ctttaccggc tactacatgc actgggtgcg ccaggcccct      840

ggccagtgtc tggaatggat gggctggatc aaccccaaca gcggcggcac caactacgcc      900

cagaaattcc agggcagagt gaccatgacc cgggacacca gcatcagcac cgcctacatg      960

gaactgagcc ggctgagaag cgacgacacc gccgtgtact actgcgccag aagccccaac     1020

ccctactact acgacagcag cggctattac taccctgggg ccttcgacat ctggggacag     1080

ggcacaatgg tcaccgtgtc tagcggaggg ggaggatctg ggggcggagg ctctggcggg     1140

ggaggaagtg ggggaggcgg aagccagcct ggactgacac agcctccaag cgtgtcagtg     1200

gcccctggac agaccgccag aatcacctgt ggcggcaaca acatcggcag caagagcgtg     1260

cactggtatc agcagaagcc cggacaggcc ccagtgctgg tggtgtacga cgacagcgat     1320

agacccagcg gcatccccga gagattcagc ggcagcaact ccggcaatac cgccaccctg     1380

accatcagca gagtggaagc cggcgacgag gccgactact actgccaagt gtgggacagc     1440

agcagcgacc actacgtgtt cggctgtggc accaaagtga ccgtgctggg aggcggggga     1500

tcagggggag gggggtcttg tcctccttgt cctgctcccg aactgctggg cggaccttcc     1560

gtgttcctgt tccccccaaa gcccaaggac accctgatga tcagccggac ccccgaagtg     1620

acctgcgtgg tggtggatgt gtcccacgag gacccagaag tgaagttcaa ttggtacgtg     1680

gacggcgtgg aagtgcacaa cgccaagacc aagcctagag aggaacagta caacagcacc     1740

taccgggtgg tgtccgtgct gacagtgctg caccaggact ggctgaacgg caaagagtac     1800

aagtgcaagg tgtccaacaa agccctgcct gcccccatcg agaaaaccat ctccaaggcc     1860

aagggccagc cccgcgagcc tcaagtgtat accctgcccc ctagccggga agagatgacc     1920

aagaaccagg tgtccctgac ctgtctcgtg aaaggcttct acccctccga tatcgccgtg     1980

gaatgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc tgtgctggac     2040

agcgacggct cattcttcct gtactccaag ctgaccgtgg acaagagccg gtggcagcag     2100

ggcaacgtgt tcagctgcag cgtgatgcac gaggccctgc acaaccacta cacacagaag     2160

tccctgagcc tgagccccgg caaa                                            2184


<210>  32
<211>  728
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  32

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Gly Lys Thr Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
225                 230                 235                 240 


Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala Ser 
                245                 250                 255     


Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr Tyr 
            260                 265                 270         


Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met Gly 
        275                 280                 285             


Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
    290                 295                 300                 


Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr Met 
305                 310                 315                 320 


Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala 
                325                 330                 335     


Arg Ser Pro Asn Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr Pro 
            340                 345                 350         


Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        355                 360                 365             


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    370                 375                 380                 


Gly Gly Gly Ser Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Val 
385                 390                 395                 400 


Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly 
                405                 410                 415     


Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val 
            420                 425                 430         


Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg 
        435                 440                 445             


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg 
    450                 455                 460                 


Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser 
465                 470                 475                 480 


Ser Ser Asp His Tyr Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu 
                485                 490                 495     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro Ala 
            500                 505                 510         


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
        515                 520                 525             


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
    530                 535                 540                 


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
545                 550                 555                 560 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
                565                 570                 575     


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
            580                 585                 590         


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
        595                 600                 605             


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
    610                 615                 620                 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
625                 630                 635                 640 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
                645                 650                 655     


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
            660                 665                 670         


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
        675                 680                 685             


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
    690                 695                 700                 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
705                 710                 715                 720 


Ser Leu Ser Leu Ser Pro Gly Lys 
                725             


<210>  33
<211>  123
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  33

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr Asn Tyr 
            20                  25                  30          


Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Ala Ala Asp Phe 
    50                  55                  60                  


Lys Arg Arg Phe Thr Phe Ser Leu Asp Thr Ser Lys Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Tyr Pro His Tyr Tyr Gly Ser Ser His Trp Tyr Phe Asp Val 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  34
<211>  257
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  34

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Asn Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr 
            100                 105                 110         


Pro Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Gly Gly Gly Gly Ser Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser 
145                 150                 155                 160 


Val Ala Pro Gly Gln Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile 
                165                 170                 175     


Gly Ser Lys Ser Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
            180                 185                 190         


Val Leu Val Val Tyr Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu 
        195                 200                 205             


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
    210                 215                 220                 


Arg Val Glu Ala Gly Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp 
225                 230                 235                 240 


Ser Ser Ser Asp His Tyr Val Phe Gly Cys Gly Thr Lys Val Thr Val 
                245                 250                 255     


Leu 
    


<210>  35
<211>  108
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  35

Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asn Asn Ile Gly Ser Lys Ser Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Val Tyr 
        35                  40                  45              


Asp Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Val Trp Asp Ser Ser Ser Asp His 
                85                  90                  95      


Tyr Val Phe Gly Cys Gly Thr Lys Val Thr Val Leu 
            100                 105             


<210>  36
<211>  129
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  36

Gln Val Gln Leu Val Glu Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Cys Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Pro Asn Pro Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr Tyr 
            100                 105                 110         


Pro Gly Ala Phe Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser 
        115                 120                 125             


Ser 
    


<210>  37
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  37
gagcccaaat cttgt                                                        15


<210>  38
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  38

Glu Pro Lys Ser Cys 
1               5   


<210>  39
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic construct

<400>  39
gacaaaactc acacatgccc accgtgccca                                        30


<210>  40
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic construct

<400>  40

Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10  


<210>  41
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  41
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca acagaagcca      120

gggaaagccc ctaaactcgt gatctattct gcatccactt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctct ccatcagcag cctgcagcct      240

gacgattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa      300

gggaccaagg ttgaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  42
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  42

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Val Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  43
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  43

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Val Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  44
<211>  2160
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  44
gagatgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgaactgggt ccgccaggct      120

ccaggggagg ggctggagtg ggtctcagct attactatta gtggtattac cgcatactac      180

accgactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctatat      240

ctgcaaatga acagcctgag ggccggggac acggccgtat attactgtgc gaaggaagaa      300

tttttacctg gaacgcacta ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct cagcgtcgac caagggccca tccgtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cctggaactc aggcgctctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tggcggaggg ggctctggcg gagggggatc cgaggtgcag      720

ctgttggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcaat      780

gtcgctggtg gctccatcag tccttactac tggacctgga tccggcagcc cccagggaag      840

tgcctggagt tgattggtta tatccactcc agtgggtaca ccgactacaa cccctccctc      900

aagagtcgag tcaccatatc aggagacacg tccaagaagc agttctccct gcacgtgagc      960

tctgtgaccg ctgcggacac ggccgtgtac ttctgtgcga gagccgattg ggacctgctt     1020

catgctcttg atatctgggg ccaagggacc ctggtcaccg tctcgagtgg cggagggggc     1080

tctgggggag ggggcagcgg cggcggagga tctgggggag ggggcagcga aattgtgttg     1140

acacagtctc catcctccct gtctacatct gtaggagaca gagtcaccat cacttgccgg     1200

gcaagtcaga gcattaggag ccatttaaat tggtatcagc agaaaccagg gaaagcccct     1260

aaactcctga tctatggtgc atccaatttg caaagtgggg tcccatcaag gttcagtggc     1320

agtggatctg ggacagattt cactctcacc attagtagtc tgcaacctga agattttgca     1380

acttactact gtcaacagag ttacagtttc cccctcactt tcggctgtgg gaccaagctg     1440

gagatcaaag gcggaggtgg ctctggcgga gggggatccg acaaaactca cacatgccca     1500

ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc     1560

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc     1620

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc     1680

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc     1740

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc     1800

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag     1860

gtctacaccc tgcccccatc ccgggaggag atgaccaaga accaggtcag cctgacctgc     1920

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg     1980

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctat     2040

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg     2100

atgcatgagg ctctgcacaa ccactacacg cagaagagct taagcctgtc tccgggtaaa     2160


<210>  45
<211>  720
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  45

Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Ile Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln 
225                 230                 235                 240 


Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu Thr Leu Ser 
                245                 250                 255     


Leu Thr Cys Asn Val Ala Gly Gly Ser Ile Ser Pro Tyr Tyr Trp Thr 
            260                 265                 270         


Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile Gly Tyr Ile 
        275                 280                 285             


His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys Ser Arg Val 
    290                 295                 300                 


Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu His Val Ser 
305                 310                 315                 320 


Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala Arg Ala Asp 
                325                 330                 335     


Trp Asp Leu Leu His Ala Leu Asp Ile Trp Gly Gln Gly Thr Leu Val 
            340                 345                 350         


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        355                 360                 365             


Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr Gln Ser Pro 
    370                 375                 380                 


Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg 
385                 390                 395                 400 


Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln Gln Lys Pro 
                405                 410                 415     


Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn Leu Gln Ser 
            420                 425                 430         


Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
        435                 440                 445             


Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
    450                 455                 460                 


Gln Gln Ser Tyr Ser Phe Pro Leu Thr Phe Gly Cys Gly Thr Lys Leu 
465                 470                 475                 480 


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr 
                485                 490                 495     


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
            500                 505                 510         


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
        515                 520                 525             


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
    530                 535                 540                 


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
545                 550                 555                 560 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
                565                 570                 575     


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
            580                 585                 590         


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
        595                 600                 605             


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
    610                 615                 620                 


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
625                 630                 635                 640 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
                645                 650                 655     


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
            660                 665                 670         


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
        675                 680                 685             


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
    690                 695                 700                 


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 715                 720 


<210>  46
<211>  124
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  46

Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Ile Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 
        115                 120                 


<210>  47
<211>  246
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  47

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asn Val Ala Gly Gly Ser Ile Ser Pro Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile 
        35                  40                  45              


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


His Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Asp Trp Asp Leu Leu His Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Leu Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys 
                245     


<210>  48
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  48

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  119
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  49

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asn Val Ala Gly Gly Ser Ile Ser Pro Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile 
        35                  40                  45              


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


His Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Asp Trp Asp Leu Leu His Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  50
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  50
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca acagaagcca      120

gggaaagccc ctaaactcgt gatctattct gcatccactt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctct ccatcagcag cctgcagcct      240

gacgattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa      300

gggaccaagg ttgaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  51
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  51

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Val Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  52
<211>  2130
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  52
gaggtgcagc tgttggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc       60

acctgcaatg tcgctggtgg ctccatcagt ccttactact ggacctggat ccggcagccc      120

ccagggaagt gcctggagtt gattggttat atccactcca gtgggtacac cgactacaac      180

ccctccctca agagtcgagt caccatatca ggagacacgt ccaagaagca gttctccctg      240

cacgtgagct ctgtgaccgc tgcggacacg gccgtgtact tctgtgcgag agccgattgg      300

gacctgcttc atgctcttga tatctggggc caagggaccc tggtcaccgt ctcgagtggc      360

ggagggggct ctgggggagg gggcagcggc ggcggaggat ctgggggagg gggcagcgaa      420

attgtgttga cacagtctcc atcctccctg tctacatctg taggagacag agtcaccatc      480

acttgccggg caagtcagag cattaggagc catttaaatt ggtatcagca gaaaccaggg      540

aaagccccta aactcctgat ctatggtgca tccaatttgc aaagtggggt cccatcaagg      600

ttcagtggca gtggatctgg gacagatttc actctcacca ttagtagtct gcaacctgaa      660

gattttgcaa cttactactg tcaacagagt tacagtttcc ccctcacttt cggctgtggg      720

accaagctgg agatcaaagg cggaggggga tccggcggag ggggctctga gatgcagctg      780

ttggagtctg ggggaggctt ggtacagcct ggggggtccc tgagactctc ctgtgcagcc      840

tctggattca cctttagcag ctatgccatg aactgggtcc gccaggctcc aggggagggg      900

ctggagtggg tctcagctat tactattagt ggtattaccg catactacac cgactccgtg      960

aagggccggt tcaccatctc cagagacaat tccaagaaca cgctatatct gcaaatgaac     1020

agcctgaggg ccggggacac ggccgtatat tactgtgcga aggaagaatt tttacctgga     1080

acgcactact actacggtat ggacgtctgg ggccaaggga ccacggtcac cgtctcctca     1140

gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg     1200

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcc     1260

tggaactcag gcgctctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     1320

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     1380

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc     1440

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     1500

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1560

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1620

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1680

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1740

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1800

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1860

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1920

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1980

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     2040

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2100

cagaagagct taagcctgtc tccgggtaaa                                      2130


<210>  53
<211>  710
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  53

Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Asn Val Ala Gly Gly Ser Ile Ser Pro Tyr 
            20                  25                  30          


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile 
        35                  40                  45              


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
65                  70                  75                  80  


His Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
                85                  90                  95      


Arg Ala Asp Trp Asp Leu Leu His Ala Leu Asp Ile Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile 
145                 150                 155                 160 


Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln 
                165                 170                 175     


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
            180                 185                 190         


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
        195                 200                 205             


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
    210                 215                 220                 


Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Leu Thr Phe Gly Cys Gly 
225                 230                 235                 240 


Thr Lys Leu Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
            260                 265                 270         


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
        275                 280                 285             


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
    290                 295                 300                 


Ser Ala Ile Thr Ile Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Ser Val 
305                 310                 315                 320 


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
                325                 330                 335     


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
            340                 345                 350         


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
        355                 360                 365             


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
385                 390                 395                 400 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        435                 440                 445             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    450                 455                 460                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
465                 470                 475                 480 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                485                 490                 495     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            580                 585                 590         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    610                 615                 620                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 


Ser Leu Ser Pro Gly Lys 
705                 710 


<210>  54
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  54
gaaattgtgt tgacacagtc tccatcctcc ctgtctacat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gagcattagg agccatttaa attggtatca gcagaaacca      120

gggaaagccc ctaaactcct gatctatggt gcatccaatt tgcaaagtgg ggtcccatca      180

aggttcagtg gcagtggatc tgggacagat ttcactctca ccattagtag tctgcaacct      240

gaagattttg caacttacta ctgtcaacag agttacagtt tccccctcac tttcggcgga      300

gggaccaagc tggagatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  55
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  55

Glu Ile Val Leu Thr Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Leu 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  56
<211>  2130
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  56
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca acagaagcca      120

gggaaagccc ctaaactcgt gatctattct gcatccactt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctct ccatcagcag cctgcagcct      240

gacgattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggctgt      300

gggaccaagg ttgaaatcaa aggcggagga ggctccggcg gaggagggtc tggaggcggg      360

ggaagtggag gaggaggctc cgagatgcag ctgttggagt ctgggggagg cttggtacag      420

cctggggggt ccctgagact ctcctgtgca gcctctggat tcacctttag cagctatgcc      480

atgaactggg tccgccaggc tccaggggag tgtctggagt gggtctcagc tattactatt      540

agtggtatta ccgcatacta caccgactcc gtgaagggcc ggttcaccat ctccagagac      600

aattccaaga acacgctata tctgcaaatg aacagcctga gggccgggga cacggccgta      660

tattactgtg cgaaggaaga atttttacct ggaacgcact actactacgg tatggacgtc      720

tggggccaag ggaccacggt caccgtctcc tcaggcggag ggggatccgg cggcggcggc      780

agcgaggtgc agctgttgga gtcgggccca ggactggtga agccttcgga gaccctgtcc      840

ctcacctgca atgtcgctgg tggctccatc agtccttact actggacctg gatccggcag      900

cccccaggga agggcctgga gttgattggt tatatccact ccagtgggta caccgactac      960

aacccctccc tcaagagtcg agtcaccata tcaggagaca cgtccaagaa gcagttctcc     1020

ctgcacgtga gctctgtgac cgctgcggac acggccgtgt acttctgtgc gagagccgat     1080

tgggacctgc ttcatgctct tgatatctgg ggccaaggga ccctggtcac cgtctcgagt     1140

gcgtcgacca agggcccatc cgtcttcccc ctggcaccct cctccaagag cacctctggg     1200

ggcacagcgg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg     1260

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca     1320

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacccagacc     1380

tacatctgca acgtgaatca caagcccagc aacaccaagg tggacaagag agttgagccc     1440

aaatcttgtg acaaaactca cacatgccca ccgtgcccag cacctgaact cctgggggga     1500

ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct     1560

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg     1620

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac     1680

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag     1740

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc     1800

aaagccaaag ggcagccccg agaaccacag gtctacaccc tgcccccatc ccgggaggag     1860

atgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc     1920

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg     1980

ctggactccg acggctcctt cttcctctat agcaagctca ccgtggacaa gagcaggtgg     2040

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg     2100

cagaagagcc tctccctgtc tccgggtaaa                                      2130


<210>  57
<211>  710
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  57

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Val Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Cys Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu 
        115                 120                 125             


Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr Ala 
145                 150                 155                 160 


Met Asn Trp Val Arg Gln Ala Pro Gly Glu Cys Leu Glu Trp Val Ser 
                165                 170                 175     


Ala Ile Thr Ile Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Ser Val Lys 
            180                 185                 190         


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
        195                 200                 205             


Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys Ala 
    210                 215                 220                 


Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp Val 
225                 230                 235                 240 


Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu 
            260                 265                 270         


Val Lys Pro Ser Glu Thr Leu Ser Leu Thr Cys Asn Val Ala Gly Gly 
        275                 280                 285             


Ser Ile Ser Pro Tyr Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys 
    290                 295                 300                 


Gly Leu Glu Leu Ile Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr 
305                 310                 315                 320 


Asn Pro Ser Leu Lys Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys 
                325                 330                 335     


Lys Gln Phe Ser Leu His Val Ser Ser Val Thr Ala Ala Asp Thr Ala 
            340                 345                 350         


Val Tyr Phe Cys Ala Arg Ala Asp Trp Asp Leu Leu His Ala Leu Asp 
        355                 360                 365             


Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
    370                 375                 380                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
385                 390                 395                 400 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                405                 410                 415     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            420                 425                 430         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        435                 440                 445             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
    450                 455                 460                 


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
465                 470                 475                 480 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
                485                 490                 495     


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
            500                 505                 510         


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
        515                 520                 525             


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
    530                 535                 540                 


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
545                 550                 555                 560 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
                565                 570                 575     


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
            580                 585                 590         


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
        595                 600                 605             


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
    610                 615                 620                 


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
625                 630                 635                 640 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
                645                 650                 655     


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
            660                 665                 670         


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
        675                 680                 685             


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
    690                 695                 700                 


Ser Leu Ser Pro Gly Lys 
705                 710 


<210>  58
<211>  642
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  58
gccatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc       60

atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca acagaagcca      120

gggaaagccc ctaaactcgt gatctattct gcatccactt tacaaagtgg ggtcccatca      180

aggttcagcg gcagtggatc tggcacagat ttcactctct ccatcagcag cctgcagcct      240

gacgattttg caacttatta ctgtctacaa gattacaatt acccgtggac gttcggccaa      300

gggaccaagg ttgaaatcaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      360

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      420

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      600

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         642


<210>  59
<211>  214
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  59

Ala Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp 
            20                  25                  30          


Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Val Ile 
        35                  40                  45              


Tyr Ser Ala Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Asp Asp Phe Ala Thr Tyr Tyr Cys Leu Gln Asp Tyr Asn Tyr Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  60
<211>  2130
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  60
gagatgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc       60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgaactgggt ccgccaggct      120

ccaggggagg ggctggagtg ggtctcagct attactatta gtggtattac cgcatactac      180

accgactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctatat      240

ctgcaaatga acagcctgag ggccggggac acggccgtat attactgtgc gaaggaagaa      300

tttttacctg gaacgcacta ctactacggt atggacgtct ggggccaagg gaccacggtc      360

accgtctcct cagcgtcgac caagggccca tccgtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cctggaactc aggcgctctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

ctcctggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtctacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct atagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cttaagcctg tctccgggta aaggcggagg gggatccggc     1380

ggagggggct ctgaggtgca gctgttggag tcgggcccag gactggtgaa gccttcggag     1440

accctgtccc tcacctgcaa tgtcgctggt ggctccatca gtccttacta ctggacctgg     1500

atccggcagc ccccagggaa gtgcctggag ttgattggtt atatccactc cagtgggtac     1560

accgactaca acccctccct caagagtcga gtcaccatat caggagacac gtccaagaag     1620

cagttctccc tgcacgtgag ctctgtgacc gctgcggaca cggccgtgta cttctgtgcg     1680

agagccgatt gggacctgct tcatgctctt gatatctggg gccaagggac cctggtcacc     1740

gtctcgagtg gcggaggggg ctctggggga gggggcagcg gcggcggagg atctggggga     1800

gggggcagcg aaattgtgtt gacacagtct ccatcctccc tgtctacatc tgtaggagac     1860

agagtcacca tcacttgccg ggcaagtcag agcattagga gccatttaaa ttggtatcag     1920

cagaaaccag ggaaagcccc taaactcctg atctatggtg catccaattt gcaaagtggg     1980

gtcccatcaa ggttcagtgg cagtggatct gggacagatt tcactctcac cattagtagt     2040

ctgcaacctg aagattttgc aacttactac tgtcaacaga gttacagttt ccccctcact     2100

ttcggctgtg ggaccaagct ggagatcaaa                                      2130


<210>  61
<211>  710
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  61

Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Glu Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Thr Ile Ser Gly Ile Thr Ala Tyr Tyr Thr Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Glu Glu Phe Leu Pro Gly Thr His Tyr Tyr Tyr Gly Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    450                 455                 460                 


Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
465                 470                 475                 480 


Thr Leu Ser Leu Thr Cys Asn Val Ala Gly Gly Ser Ile Ser Pro Tyr 
                485                 490                 495     


Tyr Trp Thr Trp Ile Arg Gln Pro Pro Gly Lys Cys Leu Glu Leu Ile 
            500                 505                 510         


Gly Tyr Ile His Ser Ser Gly Tyr Thr Asp Tyr Asn Pro Ser Leu Lys 
        515                 520                 525             


Ser Arg Val Thr Ile Ser Gly Asp Thr Ser Lys Lys Gln Phe Ser Leu 
    530                 535                 540                 


His Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 
545                 550                 555                 560 


Arg Ala Asp Trp Asp Leu Leu His Ala Leu Asp Ile Trp Gly Gln Gly 
                565                 570                 575     


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            580                 585                 590         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Ile Val Leu Thr 
        595                 600                 605             


Gln Ser Pro Ser Ser Leu Ser Thr Ser Val Gly Asp Arg Val Thr Ile 
    610                 615                 620                 


Thr Cys Arg Ala Ser Gln Ser Ile Arg Ser His Leu Asn Trp Tyr Gln 
625                 630                 635                 640 


Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Gly Ala Ser Asn 
                645                 650                 655     


Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            660                 665                 670         


Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr 
        675                 680                 685             


Tyr Tyr Cys Gln Gln Ser Tyr Ser Phe Pro Leu Thr Phe Gly Cys Gly 
    690                 695                 700                 


Thr Lys Leu Glu Ile Lys 
705                 710 


<210>  62
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  62

Glu Pro Lys Ser Cys Asp Lys Thr Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  63
<211>  18
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  63

Glu Pro Lys Ser Cys Gly Lys Thr Gly Gly Gly Gly Ser Gly Gly Gly 
1               5                   10                  15      


Gly Ser 
        


<210>  64
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  64

Glu Pro Lys Ser Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  65
<211>  75
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  65
ggtggcggtg gctctggtgg cggtggctct gagcccaaat ctgtagacaa aactcacaca       60

tgcccaccgt gccca                                                        75


<210>  66
<211>  25
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  66

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Pro Lys Ser Val Asp 
1               5                   10                  15      


Lys Thr His Thr Cys Pro Pro Cys Pro 
            20                  25  


<210>  67
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  67
ggaggcggag gatctggcgg aggcggatct tgcccaccgt gccca                       45


<210>  68
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  68

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Cys Pro Pro Cys Pro 
1               5                   10                  15  


<210>  69
<211>  60
<212>  DNA
<213>  artificial

<220>
<223>  synthetic construct

<400>  69
ggtggcggtg gctctggtgg cggtggctct gacaaaactc acacatgccc accgtgccca       60


<210>  70
<211>  20
<212>  PRT
<213>  artificial

<220>
<223>  synthetic construct

<400>  70

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro 
            20  


