                         SEQUENCE LISTING

<110>  MERCK SHARP & DOHME CORP.
       Jain, Renu
       Cua, Daniel J.
 
<120>  TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS BY INHIBITION 
       OF BLIMP-1

<130>  23172

<150>  US 61/556,695
<151>  2011-11-07

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  5165
<212>  DNA
<213>  Homo sapiens

<400>  1
gggaagccag acggttaaca cagacaaagt gctgccgtga cactcggccc tccagtgttg       60

cggagaggca agagcagcga ccgcggcacc tgtccgcccg gagctgggac gcgggcgccc      120

gggcggccgg acgaagcgag gagggaccgc cgaggtgcgc gtctgtgcgg ctcagcctgg      180

cgggggacgc ggggagaatg tggactgggt agagatgaac gagacttttc tcagatgttg      240

gatatttgct tggaaaaacg tgtgggtacg accttggctg cccccaagtg taactccagc      300

actgtgaggt ttcagggatt ggcagagggg accaagggga ccatgaaaat ggacatggag      360

gatgcggata tgactctgtg gacagaggct gagtttgaag agaagtgtac atacattgtg      420

aacgaccacc cctgggattc tggtgctgat ggcggtactt cggttcaggc ggaggcatcc      480

ttaccaagga atctgctttt caagtatgcc accaacagtg aagaggttat tggagtgatg      540

agtaaagaat acataccaaa gggcacacgt tttggacccc taataggtga aatctacacc      600

aatgacacag ttcctaagaa cgccaacagg aaatattttt ggaggatcta ttccagaggg      660

gagcttcacc acttcattga cggctttaat gaagagaaaa gcaactggat gcgctatgtg      720

aatccagcac actctccccg ggagcaaaac ctggctgcgt gtcagaacgg gatgaacatc      780

tacttctaca ccattaagcc catccctgcc aaccaggaac ttcttgtgtg gtattgtcgg      840

gactttgcag aaaggcttca ctacccttat cccggagagc tgacaatgat gaatctcaca      900

caaacacaga gcagtctaaa gcaaccgagc actgagaaaa atgaactctg cccaaagaat      960

gtcccaaaga gagagtacag cgtgaaagaa atcctaaaat tggactccaa cccctccaaa     1020

ggaaaggacc tctaccgttc taacatttca cccctcacat cagaaaagga cctcgatgac     1080

tttagaagac gtgggagccc cgaaatgccc ttctaccctc gggtcgttta ccccatccgg     1140

gcccctctgc cagaagactt tttgaaagct tccctggcct acgggatcga gagacccacg     1200

tacatcactc gctcccccat tccatcctcc accactccaa gcccctctgc aagaagcagc     1260

cccgaccaaa gcctcaagag ctccagccct cacagcagcc ctgggaatac ggtgtcccct     1320

gtgggccccg gctctcaaga gcaccgggac tcctacgctt acttgaacgc gtcctacggc     1380

acggaaggtt tgggctccta ccctggctac gcacccctgc cccacctccc gccagctttc     1440

atcccctcgt acaacgctca ctaccccaag ttcctcttgc ccccctacgg catgaattgt     1500

aatggcctga gcgctgtgag cagcatgaat ggcatcaaca actttggcct cttcccgagg     1560

ctgtgccctg tctacagcaa tctcctcggt gggggcagcc tgccccaccc catgctcaac     1620

cccacttctc tcccgagctc gctgccctca gatggagccc ggaggttgct ccagccggag     1680

catcccaggg aggtgcttgt cccggcgccc cacagtgcct tctcctttac cggggccgcc     1740

gccagcatga aggacaaggc ctgtagcccc acaagcgggt ctcccacggc gggaacagcc     1800

gccacggcag aacatgtggt gcagcccaaa gctacctcag cagcgatggc agcccccagc     1860

agcgacgaag ccatgaatct cattaaaaac aaaagaaaca tgaccggcta caagaccctt     1920

ccctacccgc tgaagaagca gaacggcaag atcaagtacg aatgcaacgt ttgcgccaag     1980

actttcggcc agctctccaa tctgaaggtc cacctgagag tgcacagtgg agaacggcct     2040

ttcaaatgtc agacttgcaa caagggcttt actcagctcg cccacctgca gaaacactac     2100

ctggtacaca cgggagaaaa gccacatgaa tgccaggtct gccacaagag atttagcagc     2160

accagcaatc tcaagaccca cctgcgactc cattctggag agaaaccata ccaatgcaag     2220

gtgtgccctg ccaagttcac ccagtttgtg cacctgaaac tgcacaagcg tctgcacacc     2280

cgggagcggc cccacaagtg ctcccagtgc cacaagaact acatccatct ctgtagcctc     2340

aaggttcacc tgaaagggaa ctgcgctgcg gccccggcgc ctgggctgcc cttggaagat     2400

ctgacccgaa tcaatgaaga aatcgagaag tttgacatca gtgacaatgc tgaccggctc     2460

gaggacgtgg aggatgacat cagtgtgatc tctgtagtgg agaaggaaat tctggccgtg     2520

gtcagaaaag agaaagaaga aactggcctg aaagtgtctt tgcaaagaaa catggggaat     2580

ggactcctct cctcagggtg cagcctttat gagtcatcag atctacccct catgaagttg     2640

cctcccagca acccactacc tctggtacct gtaaaggtca aacaagaaac agttgaacca     2700

atggatcctt aagattttca gaaaacactt attttgtttc ttaagttatg acttggtgag     2760

tcagggtgcc tgtaggaagt ggcttgtaca taatcccagc tctgcaaagc tctctcgaca     2820

gcaaatggtt tcccctcacc tctggaatta aagaaggaac tccaaagtta ctgaaatctc     2880

agggcatgaa caaggcaaag gccatatata tatatatata tatatctgta tacatattat     2940

atatacttat ttacacctgt gtctatatat ttgcccctgt gtattttgaa tatttgtgtg     3000

gacatgtttg catagccttc ccattactaa gactattacc tagtcataat tattttttca     3060

atgataatcc ttcataattt attatacaat ttatcattca gaaagcaata attaaaaaag     3120

tttacaatga ctggaaagat tccttgtaat ttgagtataa atgtattttt gtcttgtggc     3180

cattctttgt agataatttc tgcacatctg tataagtacc taagatttag ttaaacaaat     3240

atatgacttc agtcaacctc tctctctaat aatggtttga aaatgaggtt tgggtaattg     3300

ccaatgttgg acagttgatg tgttcattcc tgggatccta tcatttgaac agcattgtac     3360

ataacttggg ggtatgtgtg caggattacc caagaataac ttaagtagaa gaaacaagaa     3420

agggaatctt gtatattttt gttgatagtt catgtttttc ccccagccac aattttaccg     3480

gaagggtgac aggaaggctt taccaacctg tctctccctc caaaagagca gaatcctccc     3540

accgccctgc cctccccacc gagtcctgtg gccattcaga gcggccacat gacttttgca     3600

tccattgtat tatcagaaaa tgtgaagaag aaaaaaatgc catgttttaa aaccactgcg     3660

aaaatttccc caaagcatag gtggctttgt gtgtgtgcga tttgggggct tgagtctggg     3720

tggtgttttg ttgttggttt ttgttgcttt tttttttttt ttttttttaa tgtcaaaatt     3780

gcacaaacat ggtgctctac caggaaggat tcgaggtaga taggctcagg ccacacttta     3840

aaaacaaaca cacaaacaac aaaaaacggg tattctagtc atcttggggt aaaagcgggt     3900

aatgaacatt cctatcccca acacatcaat tgtatttttt ctgtaaaact cagattttcc     3960

tcagtatttg tgtttttaca ttttatggtt aatttaatgg aagatgaaag ggcattgcaa     4020

agttgttcaa caacagttac ctcattgagt gtgtccagta gtgcaggaaa tgatgtctta     4080

tctaatgatt tgcttctcta gaggagaaac cgagtaaatg tgctccagca agatagactt     4140

tgtgttattc tatcttttat tctgctaagc ccaaagatta catgttggtg ttcaaagtgt     4200

agcaaaaaat gatgtatatt tataaatcta tttataccac tatatcatat gtatatatat     4260

ttataaccac ttaaattgtg agccaagcca tgtaaaagat ctactttttc taagggcaaa     4320

aaaaaaaaaa aaaaaaaaag aacactcctt tctgagactt tgcttaatac ttggtgacct     4380

cacaatcacg tcggtatgat tgggcaccct tgcctactgt aagagaccct aaaaccttgg     4440

tgcagtggtg gggaccacaa aacaaccagg gaggaagaga tacatcattt tttagtatta     4500

aggaccatct aagacagctc tatttttttt ttgccacttt atgattatgt ggtcacaccc     4560

aagtcacaga aataaaaaac tgactttacc gctgcaattt ttctgttttc ctccttacta     4620

aatactgata cattactcca atctatttta taattatatt tgacattttg ttcacatcaa     4680

ctaatgttca cctgtagaag agaacaaatt tcgaataatc cagggaaacc caagagcctt     4740

actggtcttc tgtaacttcc aagactgaca gctttttatg tatcagtgtt tgataaacac     4800

agtccttaac tgaaggtaaa ccaaagcatc acgttgacat tagaccaaat acttttgatt     4860

cccaactact cgtttgttct ttttctcctt ttgtgctttc ccatagtgag aatttttata     4920

aagacttctt gcttctctca ccatccatcc ttctcttttc tgcctcttac atgtgaatgt     4980

tgagcccaca atcaacagtg gttttatttt ttcctctact caaagttaaa actgaccaaa     5040

gttactggct ttttactttg ctagaacaac aaactatctt atgtttacat actggtttac     5100

aatgttattt atgtgcaaat tgtcaaaatg taaattaaat ataaatgttc atgctttacc     5160

aaaat                                                                 5165


<210>  2
<211>  825
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Asp Ile Cys Leu Glu Lys Arg Val Gly Thr Thr Leu Ala Ala 
1               5                   10                  15      


Pro Lys Cys Asn Ser Ser Thr Val Arg Phe Gln Gly Leu Ala Glu Gly 
            20                  25                  30          


Thr Lys Gly Thr Met Lys Met Asp Met Glu Asp Ala Asp Met Thr Leu 
        35                  40                  45              


Trp Thr Glu Ala Glu Phe Glu Glu Lys Cys Thr Tyr Ile Val Asn Asp 
    50                  55                  60                  


His Pro Trp Asp Ser Gly Ala Asp Gly Gly Thr Ser Val Gln Ala Glu 
65                  70                  75                  80  


Ala Ser Leu Pro Arg Asn Leu Leu Phe Lys Tyr Ala Thr Asn Ser Glu 
                85                  90                  95      


Glu Val Ile Gly Val Met Ser Lys Glu Tyr Ile Pro Lys Gly Thr Arg 
            100                 105                 110         


Phe Gly Pro Leu Ile Gly Glu Ile Tyr Thr Asn Asp Thr Val Pro Lys 
        115                 120                 125             


Asn Ala Asn Arg Lys Tyr Phe Trp Arg Ile Tyr Ser Arg Gly Glu Leu 
    130                 135                 140                 


His His Phe Ile Asp Gly Phe Asn Glu Glu Lys Ser Asn Trp Met Arg 
145                 150                 155                 160 


Tyr Val Asn Pro Ala His Ser Pro Arg Glu Gln Asn Leu Ala Ala Cys 
                165                 170                 175     


Gln Asn Gly Met Asn Ile Tyr Phe Tyr Thr Ile Lys Pro Ile Pro Ala 
            180                 185                 190         


Asn Gln Glu Leu Leu Val Trp Tyr Cys Arg Asp Phe Ala Glu Arg Leu 
        195                 200                 205             


His Tyr Pro Tyr Pro Gly Glu Leu Thr Met Met Asn Leu Thr Gln Thr 
    210                 215                 220                 


Gln Ser Ser Leu Lys Gln Pro Ser Thr Glu Lys Asn Glu Leu Cys Pro 
225                 230                 235                 240 


Lys Asn Val Pro Lys Arg Glu Tyr Ser Val Lys Glu Ile Leu Lys Leu 
                245                 250                 255     


Asp Ser Asn Pro Ser Lys Gly Lys Asp Leu Tyr Arg Ser Asn Ile Ser 
            260                 265                 270         


Pro Leu Thr Ser Glu Lys Asp Leu Asp Asp Phe Arg Arg Arg Gly Ser 
        275                 280                 285             


Pro Glu Met Pro Phe Tyr Pro Arg Val Val Tyr Pro Ile Arg Ala Pro 
    290                 295                 300                 


Leu Pro Glu Asp Phe Leu Lys Ala Ser Leu Ala Tyr Gly Ile Glu Arg 
305                 310                 315                 320 


Pro Thr Tyr Ile Thr Arg Ser Pro Ile Pro Ser Ser Thr Thr Pro Ser 
                325                 330                 335     


Pro Ser Ala Arg Ser Ser Pro Asp Gln Ser Leu Lys Ser Ser Ser Pro 
            340                 345                 350         


His Ser Ser Pro Gly Asn Thr Val Ser Pro Val Gly Pro Gly Ser Gln 
        355                 360                 365             


Glu His Arg Asp Ser Tyr Ala Tyr Leu Asn Ala Ser Tyr Gly Thr Glu 
    370                 375                 380                 


Gly Leu Gly Ser Tyr Pro Gly Tyr Ala Pro Leu Pro His Leu Pro Pro 
385                 390                 395                 400 


Ala Phe Ile Pro Ser Tyr Asn Ala His Tyr Pro Lys Phe Leu Leu Pro 
                405                 410                 415     


Pro Tyr Gly Met Asn Cys Asn Gly Leu Ser Ala Val Ser Ser Met Asn 
            420                 425                 430         


Gly Ile Asn Asn Phe Gly Leu Phe Pro Arg Leu Cys Pro Val Tyr Ser 
        435                 440                 445             


Asn Leu Leu Gly Gly Gly Ser Leu Pro His Pro Met Leu Asn Pro Thr 
    450                 455                 460                 


Ser Leu Pro Ser Ser Leu Pro Ser Asp Gly Ala Arg Arg Leu Leu Gln 
465                 470                 475                 480 


Pro Glu His Pro Arg Glu Val Leu Val Pro Ala Pro His Ser Ala Phe 
                485                 490                 495     


Ser Phe Thr Gly Ala Ala Ala Ser Met Lys Asp Lys Ala Cys Ser Pro 
            500                 505                 510         


Thr Ser Gly Ser Pro Thr Ala Gly Thr Ala Ala Thr Ala Glu His Val 
        515                 520                 525             


Val Gln Pro Lys Ala Thr Ser Ala Ala Met Ala Ala Pro Ser Ser Asp 
    530                 535                 540                 


Glu Ala Met Asn Leu Ile Lys Asn Lys Arg Asn Met Thr Gly Tyr Lys 
545                 550                 555                 560 


Thr Leu Pro Tyr Pro Leu Lys Lys Gln Asn Gly Lys Ile Lys Tyr Glu 
                565                 570                 575     


Cys Asn Val Cys Ala Lys Thr Phe Gly Gln Leu Ser Asn Leu Lys Val 
            580                 585                 590         


His Leu Arg Val His Ser Gly Glu Arg Pro Phe Lys Cys Gln Thr Cys 
        595                 600                 605             


Asn Lys Gly Phe Thr Gln Leu Ala His Leu Gln Lys His Tyr Leu Val 
    610                 615                 620                 


His Thr Gly Glu Lys Pro His Glu Cys Gln Val Cys His Lys Arg Phe 
625                 630                 635                 640 


Ser Ser Thr Ser Asn Leu Lys Thr His Leu Arg Leu His Ser Gly Glu 
                645                 650                 655     


Lys Pro Tyr Gln Cys Lys Val Cys Pro Ala Lys Phe Thr Gln Phe Val 
            660                 665                 670         


His Leu Lys Leu His Lys Arg Leu His Thr Arg Glu Arg Pro His Lys 
        675                 680                 685             


Cys Ser Gln Cys His Lys Asn Tyr Ile His Leu Cys Ser Leu Lys Val 
    690                 695                 700                 


His Leu Lys Gly Asn Cys Ala Ala Ala Pro Ala Pro Gly Leu Pro Leu 
705                 710                 715                 720 


Glu Asp Leu Thr Arg Ile Asn Glu Glu Ile Glu Lys Phe Asp Ile Ser 
                725                 730                 735     


Asp Asn Ala Asp Arg Leu Glu Asp Val Glu Asp Asp Ile Ser Val Ile 
            740                 745                 750         


Ser Val Val Glu Lys Glu Ile Leu Ala Val Val Arg Lys Glu Lys Glu 
        755                 760                 765             


Glu Thr Gly Leu Lys Val Ser Leu Gln Arg Asn Met Gly Asn Gly Leu 
    770                 775                 780                 


Leu Ser Ser Gly Cys Ser Leu Tyr Glu Ser Ser Asp Leu Pro Leu Met 
785                 790                 795                 800 


Lys Leu Pro Pro Ser Asn Pro Leu Pro Leu Val Pro Val Lys Val Lys 
                805                 810                 815     


Gln Glu Thr Val Glu Pro Met Asp Pro 
            820                 825 


<210>  3
<211>  4753
<212>  DNA
<213>  Homo sapiens

<400>  3
agtttgacgt cgtcagccgg cttggtcttc tacccagtga ctcaaagcac taaaagtcag       60

cataatcgga actgaagtca gtagcatcgc ccatttgcca ttcactgcag tagcaaaagt      120

agtactctgt ggtgggttaa tcggtttgag gcagctcctt aaatgaacat ttgtgtttca      180

tttttctgtt attttcccga acatgaaaag acgataaaac tgaaatggaa aagatctatt      240

ccagagggga gcttcaccac ttcattgacg gctttaatga agagaaaagc aactggatgc      300

gctatgtgaa tccagcacac tctccccggg agcaaaacct ggctgcgtgt cagaacggga      360

tgaacatcta cttctacacc attaagccca tccctgccaa ccaggaactt cttgtgtggt      420

attgtcggga ctttgcagaa aggcttcact acccttatcc cggagagctg acaatgatga      480

atctcacaca aacacagagc agtctaaagc aaccgagcac tgagaaaaat gaactctgcc      540

caaagaatgt cccaaagaga gagtacagcg tgaaagaaat cctaaaattg gactccaacc      600

cctccaaagg aaaggacctc taccgttcta acatttcacc cctcacatca gaaaaggacc      660

tcgatgactt tagaagacgt gggagccccg aaatgccctt ctaccctcgg gtcgtttacc      720

ccatccgggc ccctctgcca gaagactttt tgaaagcttc cctggcctac gggatcgaga      780

gacccacgta catcactcgc tcccccattc catcctccac cactccaagc ccctctgcaa      840

gaagcagccc cgaccaaagc ctcaagagct ccagccctca cagcagccct gggaatacgg      900

tgtcccctgt gggccccggc tctcaagagc accgggactc ctacgcttac ttgaacgcgt      960

cctacggcac ggaaggtttg ggctcctacc ctggctacgc acccctgccc cacctcccgc     1020

cagctttcat cccctcgtac aacgctcact accccaagtt cctcttgccc ccctacggca     1080

tgaattgtaa tggcctgagc gctgtgagca gcatgaatgg catcaacaac tttggcctct     1140

tcccgaggct gtgccctgtc tacagcaatc tcctcggtgg gggcagcctg ccccacccca     1200

tgctcaaccc cacttctctc ccgagctcgc tgccctcaga tggagcccgg aggttgctcc     1260

agccggagca tcccagggag gtgcttgtcc cggcgcccca cagtgccttc tcctttaccg     1320

gggccgccgc cagcatgaag gacaaggcct gtagccccac aagcgggtct cccacggcgg     1380

gaacagccgc cacggcagaa catgtggtgc agcccaaagc tacctcagca gcgatggcag     1440

cccccagcag cgacgaagcc atgaatctca ttaaaaacaa aagaaacatg accggctaca     1500

agacccttcc ctacccgctg aagaagcaga acggcaagat caagtacgaa tgcaacgttt     1560

gcgccaagac tttcggccag ctctccaatc tgaaggtcca cctgagagtg cacagtggag     1620

aacggccttt caaatgtcag acttgcaaca agggctttac tcagctcgcc cacctgcaga     1680

aacactacct ggtacacacg ggagaaaagc cacatgaatg ccaggtctgc cacaagagat     1740

ttagcagcac cagcaatctc aagacccacc tgcgactcca ttctggagag aaaccatacc     1800

aatgcaaggt gtgccctgcc aagttcaccc agtttgtgca cctgaaactg cacaagcgtc     1860

tgcacacccg ggagcggccc cacaagtgct cccagtgcca caagaactac atccatctct     1920

gtagcctcaa ggttcacctg aaagggaact gcgctgcggc cccggcgcct gggctgccct     1980

tggaagatct gacccgaatc aatgaagaaa tcgagaagtt tgacatcagt gacaatgctg     2040

accggctcga ggacgtggag gatgacatca gtgtgatctc tgtagtggag aaggaaattc     2100

tggccgtggt cagaaaagag aaagaagaaa ctggcctgaa agtgtctttg caaagaaaca     2160

tggggaatgg actcctctcc tcagggtgca gcctttatga gtcatcagat ctacccctca     2220

tgaagttgcc tcccagcaac ccactacctc tggtacctgt aaaggtcaaa caagaaacag     2280

ttgaaccaat ggatccttaa gattttcaga aaacacttat tttgtttctt aagttatgac     2340

ttggtgagtc agggtgcctg taggaagtgg cttgtacata atcccagctc tgcaaagctc     2400

tctcgacagc aaatggtttc ccctcacctc tggaattaaa gaaggaactc caaagttact     2460

gaaatctcag ggcatgaaca aggcaaaggc catatatata tatatatata tatctgtata     2520

catattatat atacttattt acacctgtgt ctatatattt gcccctgtgt attttgaata     2580

tttgtgtgga catgtttgca tagccttccc attactaaga ctattaccta gtcataatta     2640

ttttttcaat gataatcctt cataatttat tatacaattt atcattcaga aagcaataat     2700

taaaaaagtt tacaatgact ggaaagattc cttgtaattt gagtataaat gtatttttgt     2760

cttgtggcca ttctttgtag ataatttctg cacatctgta taagtaccta agatttagtt     2820

aaacaaatat atgacttcag tcaacctctc tctctaataa tggtttgaaa atgaggtttg     2880

ggtaattgcc aatgttggac agttgatgtg ttcattcctg ggatcctatc atttgaacag     2940

cattgtacat aacttggggg tatgtgtgca ggattaccca agaataactt aagtagaaga     3000

aacaagaaag ggaatcttgt atatttttgt tgatagttca tgtttttccc ccagccacaa     3060

ttttaccgga agggtgacag gaaggcttta ccaacctgtc tctccctcca aaagagcaga     3120

atcctcccac cgccctgccc tccccaccga gtcctgtggc cattcagagc ggccacatga     3180

cttttgcatc cattgtatta tcagaaaatg tgaagaagaa aaaaatgcca tgttttaaaa     3240

ccactgcgaa aatttcccca aagcataggt ggctttgtgt gtgtgcgatt tgggggcttg     3300

agtctgggtg gtgttttgtt gttggttttt gttgcttttt tttttttttt ttttttaatg     3360

tcaaaattgc acaaacatgg tgctctacca ggaaggattc gaggtagata ggctcaggcc     3420

acactttaaa aacaaacaca caaacaacaa aaaacgggta ttctagtcat cttggggtaa     3480

aagcgggtaa tgaacattcc tatccccaac acatcaattg tattttttct gtaaaactca     3540

gattttcctc agtatttgtg tttttacatt ttatggttaa tttaatggaa gatgaaaggg     3600

cattgcaaag ttgttcaaca acagttacct cattgagtgt gtccagtagt gcaggaaatg     3660

atgtcttatc taatgatttg cttctctaga ggagaaaccg agtaaatgtg ctccagcaag     3720

atagactttg tgttattcta tcttttattc tgctaagccc aaagattaca tgttggtgtt     3780

caaagtgtag caaaaaatga tgtatattta taaatctatt tataccacta tatcatatgt     3840

atatatattt ataaccactt aaattgtgag ccaagccatg taaaagatct actttttcta     3900

agggcaaaaa aaaaaaaaaa aaaaaaagaa cactcctttc tgagactttg cttaatactt     3960

ggtgacctca caatcacgtc ggtatgattg ggcacccttg cctactgtaa gagaccctaa     4020

aaccttggtg cagtggtggg gaccacaaaa caaccaggga ggaagagata catcattttt     4080

tagtattaag gaccatctaa gacagctcta tttttttttt gccactttat gattatgtgg     4140

tcacacccaa gtcacagaaa taaaaaactg actttaccgc tgcaattttt ctgttttcct     4200

ccttactaaa tactgataca ttactccaat ctattttata attatatttg acattttgtt     4260

cacatcaact aatgttcacc tgtagaagag aacaaatttc gaataatcca gggaaaccca     4320

agagccttac tggtcttctg taacttccaa gactgacagc tttttatgta tcagtgtttg     4380

ataaacacag tccttaactg aaggtaaacc aaagcatcac gttgacatta gaccaaatac     4440

ttttgattcc caactactcg tttgttcttt ttctcctttt gtgctttccc atagtgagaa     4500

tttttataaa gacttcttgc ttctctcacc atccatcctt ctcttttctg cctcttacat     4560

gtgaatgttg agcccacaat caacagtggt tttatttttt cctctactca aagttaaaac     4620

tgaccaaagt tactggcttt ttactttgct agaacaacaa actatcttat gtttacatac     4680

tggtttacaa tgttatttat gtgcaaattg tcaaaatgta aattaaatat aaatgttcat     4740

gctttaccaa aat                                                        4753


<210>  4
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Lys Ile Tyr Ser Arg Gly Glu Leu His His Phe Ile Asp Gly 
1               5                   10                  15      


Phe Asn Glu Glu Lys Ser Asn Trp Met Arg Tyr Val Asn Pro Ala His 
            20                  25                  30          


Ser Pro Arg Glu Gln Asn Leu Ala Ala Cys Gln Asn Gly Met Asn Ile 
        35                  40                  45              


Tyr Phe Tyr Thr Ile Lys Pro Ile Pro Ala Asn Gln Glu Leu Leu Val 
    50                  55                  60                  


Trp Tyr Cys Arg Asp Phe Ala Glu Arg Leu His Tyr Pro Tyr Pro Gly 
65                  70                  75                  80  


Glu Leu Thr Met Met Asn Leu Thr Gln Thr Gln Ser Ser Leu Lys Gln 
                85                  90                  95      


Pro Ser Thr Glu Lys Asn Glu Leu Cys Pro Lys Asn Val Pro Lys Arg 
            100                 105                 110         


Glu Tyr Ser Val Lys Glu Ile Leu Lys Leu Asp Ser Asn Pro Ser Lys 
        115                 120                 125             


Gly Lys Asp Leu Tyr Arg Ser Asn Ile Ser Pro Leu Thr Ser Glu Lys 
    130                 135                 140                 


Asp Leu Asp Asp Phe Arg Arg Arg Gly Ser Pro Glu Met Pro Phe Tyr 
145                 150                 155                 160 


Pro Arg Val Val Tyr Pro Ile Arg Ala Pro Leu Pro Glu Asp Phe Leu 
                165                 170                 175     


Lys Ala Ser Leu Ala Tyr Gly Ile Glu Arg Pro Thr Tyr Ile Thr Arg 
            180                 185                 190         


Ser Pro Ile Pro Ser Ser Thr Thr Pro Ser Pro Ser Ala Arg Ser Ser 
        195                 200                 205             


Pro Asp Gln Ser Leu Lys Ser Ser Ser Pro His Ser Ser Pro Gly Asn 
    210                 215                 220                 


Thr Val Ser Pro Val Gly Pro Gly Ser Gln Glu His Arg Asp Ser Tyr 
225                 230                 235                 240 


Ala Tyr Leu Asn Ala Ser Tyr Gly Thr Glu Gly Leu Gly Ser Tyr Pro 
                245                 250                 255     


Gly Tyr Ala Pro Leu Pro His Leu Pro Pro Ala Phe Ile Pro Ser Tyr 
            260                 265                 270         


Asn Ala His Tyr Pro Lys Phe Leu Leu Pro Pro Tyr Gly Met Asn Cys 
        275                 280                 285             


Asn Gly Leu Ser Ala Val Ser Ser Met Asn Gly Ile Asn Asn Phe Gly 
    290                 295                 300                 


Leu Phe Pro Arg Leu Cys Pro Val Tyr Ser Asn Leu Leu Gly Gly Gly 
305                 310                 315                 320 


Ser Leu Pro His Pro Met Leu Asn Pro Thr Ser Leu Pro Ser Ser Leu 
                325                 330                 335     


Pro Ser Asp Gly Ala Arg Arg Leu Leu Gln Pro Glu His Pro Arg Glu 
            340                 345                 350         


Val Leu Val Pro Ala Pro His Ser Ala Phe Ser Phe Thr Gly Ala Ala 
        355                 360                 365             


Ala Ser Met Lys Asp Lys Ala Cys Ser Pro Thr Ser Gly Ser Pro Thr 
    370                 375                 380                 


Ala Gly Thr Ala Ala Thr Ala Glu His Val Val Gln Pro Lys Ala Thr 
385                 390                 395                 400 


Ser Ala Ala Met Ala Ala Pro Ser Ser Asp Glu Ala Met Asn Leu Ile 
                405                 410                 415     


Lys Asn Lys Arg Asn Met Thr Gly Tyr Lys Thr Leu Pro Tyr Pro Leu 
            420                 425                 430         


Lys Lys Gln Asn Gly Lys Ile Lys Tyr Glu Cys Asn Val Cys Ala Lys 
        435                 440                 445             


Thr Phe Gly Gln Leu Ser Asn Leu Lys Val His Leu Arg Val His Ser 
    450                 455                 460                 


Gly Glu Arg Pro Phe Lys Cys Gln Thr Cys Asn Lys Gly Phe Thr Gln 
465                 470                 475                 480 


Leu Ala His Leu Gln Lys His Tyr Leu Val His Thr Gly Glu Lys Pro 
                485                 490                 495     


His Glu Cys Gln Val Cys His Lys Arg Phe Ser Ser Thr Ser Asn Leu 
            500                 505                 510         


Lys Thr His Leu Arg Leu His Ser Gly Glu Lys Pro Tyr Gln Cys Lys 
        515                 520                 525             


Val Cys Pro Ala Lys Phe Thr Gln Phe Val His Leu Lys Leu His Lys 
    530                 535                 540                 


Arg Leu His Thr Arg Glu Arg Pro His Lys Cys Ser Gln Cys His Lys 
545                 550                 555                 560 


Asn Tyr Ile His Leu Cys Ser Leu Lys Val His Leu Lys Gly Asn Cys 
                565                 570                 575     


Ala Ala Ala Pro Ala Pro Gly Leu Pro Leu Glu Asp Leu Thr Arg Ile 
            580                 585                 590         


Asn Glu Glu Ile Glu Lys Phe Asp Ile Ser Asp Asn Ala Asp Arg Leu 
        595                 600                 605             


Glu Asp Val Glu Asp Asp Ile Ser Val Ile Ser Val Val Glu Lys Glu 
    610                 615                 620                 


Ile Leu Ala Val Val Arg Lys Glu Lys Glu Glu Thr Gly Leu Lys Val 
625                 630                 635                 640 


Ser Leu Gln Arg Asn Met Gly Asn Gly Leu Leu Ser Ser Gly Cys Ser 
                645                 650                 655     


Leu Tyr Glu Ser Ser Asp Leu Pro Leu Met Lys Leu Pro Pro Ser Asn 
            660                 665                 670         


Pro Leu Pro Leu Val Pro Val Lys Val Lys Gln Glu Thr Val Glu Pro 
        675                 680                 685             


Met Asp Pro 
    690     


<210>  5
<211>  5143
<212>  DNA
<213>  Mus musculus

<400>  5
actcggccct ccagtgtcgc ggagacgcaa gagcagcgcg cagcacctgt ccgcccggag       60

cgagcccggc ccgcggccgt agaaaaggag ggaccgccga ggtgcgcgtc agtactgctc      120

agcccggcag ggacgcggga ggatgtggac tgggtggaca tgagagaggc ttatctcaga      180

tgttggatct tctcttggaa aaacgtgtgg gtacgacctt ggctgccccc aagtctagct      240

ccggctccgt gaagtttcaa ggactggcag agactgggat catgaaaatg gacatggagg      300

acgctgatat gactttgtgg acagaggccg agtttgaaga gaagtgtaca tacatagtga      360

acgaccaccc ctgggattcc ggcgctgacg ggggtacttc tgttcaagcc gaggcatcct      420

taccaaggaa cctgcttttc aagtatgctg ccaacaacag caaagaggtt attggcgtgg      480

taagtaagga gtacataccg aagggaacac gctttggacc cctcatcggt gaagtctaca      540

ctaatgacac agttcccaag aatgccaaca ggaagtattt ttggcggatc tattccagag      600

aggagttcca ccacttcatt gatggcttta atgaggagaa aagcaactgg atgcgctacg      660

tgaatccagc tcactctgcc cgggagcaaa acctggctgc ctgtcagaac gggatgaaca      720

tctacttcta cactattaag cctatccctg ccaaccagga acttcttgtg tggtattgtc      780

gggactttgc ggagaggctc cactaccctt atcctggaga gctcacagtg ataaatctca      840

cacaaacgga aagcaaccca aagcaataca gtagtgagaa aaatgaactc tacccaaaga      900

gtgtccccaa gagagagtac agcgtgaaag aaattctaaa actggactcc aatccctcca      960

aaaggaagga catctaccgt tccaacattt cacccttcac tttagaaaag gacatggatg     1020

gctttcggaa aaatgggagc cccgacatgc ccttctaccc tcgggtggtt tatcctatcc     1080

gggcacctct gccagaagac tttttgaaag cgtccctggc ctatgggatg gagagaccca     1140

cctacataac tcacagtccc cttccgtctt ccacaactcc aagtccccct gcgagcagca     1200

gcccggagca gagccttaag agctccagcc cccacagcag cccgggaaac acggtgtcac     1260

ccctggcgcc aggcctccca gaacaccggg actcctactc ctacttgaat gtttcctatg     1320

gttccgaggg cctgggctcc taccctggct atgcacctgc cccccacctc ccaccagctt     1380

tcattccttc ttacaatgct cactacccca agttcctgtt gccaccgtac ggcattagtt     1440

ccaatggctt gagcaccatg aacaacatca atggtatcaa caacttcagc ctcttcccta     1500

ggttgtatcc cgtctacagt aacctcctta gtggcagcag cctgcctcat cccatgctca     1560

atccagcttc cctaccgagt tccctgccta ccgatggagc ccggaggctg cttccaccgg     1620

agcaccccaa agaggtgctt atcccagcac cccacagtgc cttctccctt accggggctg     1680

cagccagcat gaaggacgag agtagtcccc ccagcggatc tccaacggcg ggaactgcag     1740

ccacgtcaga acacgtggta caacccaaag ctacctcatc agtgatggcg gcccccagca     1800

ctgacggagc catgaatctc attaaaaaca aacgaaacat gactggttac aagactcttc     1860

cttaccctct gaagaaacag aatggcaaga tcaagtatga gtgcaatgtc tgtgccaaga     1920

cgttcggtca gctctccaac ctgaaggtcc acctgagagt gcacagtgga gaacggcctt     1980

tcaagtgcca gacctgcaac aagggtttta ctcagctcgc ccacctgcag aaacactact     2040

tggtacacac aggagagaag ccacatgagt gccaggtctg ccacaagaga tttagcagca     2100

caagcaatct caagacccac cttcgattgc attctggaga aaaaccttac caatgtaagg     2160

tgtgccctgc caagtttacg caatttgtgc acctgaagct gcacaagcga ctgcataccc     2220

gggagcggcc tcacaagtgt gcccagtgtc acaagagcta catccatctc tgcagcctca     2280

aggtccacct gaagggcaac tgccctgcgg gcccagctgc tgggctgcct ttggaggatc     2340

tgacccgaat caatgaagaa attgagaggt tcgacatcag cgacaatgca gaccgtcttg     2400

aggacatgga ggacagtgtc gatgtgacct ccatggtgga gaaggagatt ctagctgtgg     2460

tcagaaaaga gaaagaagaa accagtctga aagtgtcttt gcaaagaaac atggggaacg     2520

gcctcctctc ctcagggtgc agcctctatg agtcatcgga cctgtccctc atgaagttgc     2580

ctcacagcaa cccactacct ctggtgcctg taaaggtcaa acaagaaaca gttgaaccga     2640

tggatcctta agattttcag aaaataagtg tttcgtgttg cttcttaggg tatggcttgg     2700

tgaatcaggg tgcctttagc aaattgcttg tacatgactc cagatctgca aagctccgct     2760

ggcaccgggt gcttccctgc acctctctgg aattaaagaa ggactccaat gttaccaaaa     2820

tctcagggca taaatgaggc aaagactcac tatatataca tatatacata tatacatatt     2880

ataaatatat atatacttat ttacagccat gtctatatat ttgaacctgt gtattttgaa     2940

tatttgtgtg gatatgtttg catagcgcct tcctattact aaaactattg cctagccata     3000

attatttttt caatgataat tcttcataat ttattataca gtttatcttt caaaaagcaa     3060

taattaaaga agtttacaat gactggaaag attctttgta atttgagtat aaatgttgta     3120

tctttgtcct gtggccattc tttgtagata atttctgcac atctgtttaa atgcctgaga     3180

cttagaagat agctctgtga tttcaggcaa cctttctcta tgataatgct ttaaaatgag     3240

gttttgatat tgccaaagtc atgtggttgg tgtgttaact cagaagatca cacaatctga     3300

gtgacattct ctaagttggg gatacatgtg cagaattgct cagcaataat ttgaggggaa     3360

ggaagaagaa aaatatttta tgtttcagaa tgatggtttg gttttcctcc tcctagtcac     3420

aattttacca aacagtgaca ggaaggcttt gccaacctgt ctcccaatgt cacatgacca     3480

ttctgagtgg ccatatgact ttggcatccc tgggtgttat ctgaaaatgt gaagaagata     3540

aaaaagccgt gttcagaaga tctgtcgtaa agcacagatg ttgtgtgtgt gtgtgtgtgg     3600

gttggggggt ttgagtctgg ctgtcatttt gctgttggct tgtttttgtt tttttaatat     3660

caaaattgca caaagctggt gccctaccaa gaaggatttg atatagaaag gctcaggcca     3720

cacttaaaat acaagcaagc aaagagaaca gaaaaaaata aaagtaaaaa cgggtattct     3780

tatcatctta ggttaagcgg gtaatgaaca ttcctgtccc caacgcatca actgtattgt     3840

atctgtaaaa ctcagctttt ctcagtattt gtgtttttgc attgtataat taacttaatt     3900

aaagatgaaa gggcattgca aaagtgttca acaattacct cattgagtgt atccagtagg     3960

agtgcaggaa ttaatgtcgt atctcatgag ttgctaccca gctgagcgtg tgtgcttcca     4020

aatggtaggc tgggtggttc ggtcctgtat tctcctaagc ccaaaggtta cctgttggtg     4080

ttcaaggtgt aataaagaat gctgtatatt tatgaaccta tttataccag tataccatgt     4140

gtatatatga tatatttata accacttaaa ttgtgagcca agccatgtaa aagaacctat     4200

ttttcctaag agcaaaaaga atctctctga agttttgctt aaaactccat gacctcgcta     4260

tgactttggt gcttgggcac caccctgcct actaccagag agcagagcac ctcagtgcag     4320

aggtgagggt gtgtagcatc ttgggatgga tagaaacacc acaccatcca gtcgcatttg     4380

atggccttgc tacatgtgtg tcagttgggt cacagaataa aaatcatttt tctatttctg     4440

ctctcctctt cctcttcctc ttcttcttcc tctttctctc cctcctctag aaccctgact     4500

catgctcact gctcagtctg atgcttacct tagagttttg tatatataga tcaacttaca     4560

aagagggaaa acttcagatc ctctggggga aacccaagag ccttactgac ctgttgctgt     4620

gactagctag atgggtttct ctttaccttc caaggatcaa aaccagagat tccacacatg     4680

ctagcaagca agcaagctgt cactgggctg cagccccaac aagactgaca tttctggatg     4740

catctgtatt tgagaaaaat actcacttaa ttgtaggtta accaaagcat gacctgacat     4800

tgacaccaaa tacaaatacg atttctttgc agtgaacttg ggttgttttc ctcctgtgct     4860

tttcttgtgt tgggaggatt tttacaagga caattgcttt tcttgccatc tgtcttcctc     4920

ttaggcctct tacatgagag tgttgagccc acaatgaaca gtggttggtt ggttggttgg     4980

ttggtttgtt tgtttgtttt ttcctcagag ttaaaactga ccaaagttat tggcttttta     5040

ctttgctaga acaacaaact atcttatgtt tacgtactgg tttacattgt tatttatgtg     5100

caaattgtca aaatgtaaat taaaatataa atgttcatgc ttt                       5143


<210>  6
<211>  823
<212>  PRT
<213>  Mus musculus

<400>  6

Met Leu Asp Leu Leu Leu Glu Lys Arg Val Gly Thr Thr Leu Ala Ala 
1               5                   10                  15      


Pro Lys Ser Ser Ser Gly Ser Val Lys Phe Gln Gly Leu Ala Glu Thr 
            20                  25                  30          


Gly Ile Met Lys Met Asp Met Glu Asp Ala Asp Met Thr Leu Trp Thr 
        35                  40                  45              


Glu Ala Glu Phe Glu Glu Lys Cys Thr Tyr Ile Val Asn Asp His Pro 
    50                  55                  60                  


Trp Asp Ser Gly Ala Asp Gly Gly Thr Ser Val Gln Ala Glu Ala Ser 
65                  70                  75                  80  


Leu Pro Arg Asn Leu Leu Phe Lys Tyr Ala Ala Asn Asn Ser Lys Glu 
                85                  90                  95      


Val Ile Gly Val Val Ser Lys Glu Tyr Ile Pro Lys Gly Thr Arg Phe 
            100                 105                 110         


Gly Pro Leu Ile Gly Glu Val Tyr Thr Asn Asp Thr Val Pro Lys Asn 
        115                 120                 125             


Ala Asn Arg Lys Tyr Phe Trp Arg Ile Tyr Ser Arg Glu Glu Phe His 
    130                 135                 140                 


His Phe Ile Asp Gly Phe Asn Glu Glu Lys Ser Asn Trp Met Arg Tyr 
145                 150                 155                 160 


Val Asn Pro Ala His Ser Ala Arg Glu Gln Asn Leu Ala Ala Cys Gln 
                165                 170                 175     


Asn Gly Met Asn Ile Tyr Phe Tyr Thr Ile Lys Pro Ile Pro Ala Asn 
            180                 185                 190         


Gln Glu Leu Leu Val Trp Tyr Cys Arg Asp Phe Ala Glu Arg Leu His 
        195                 200                 205             


Tyr Pro Tyr Pro Gly Glu Leu Thr Val Ile Asn Leu Thr Gln Thr Glu 
    210                 215                 220                 


Ser Asn Pro Lys Gln Tyr Ser Ser Glu Lys Asn Glu Leu Tyr Pro Lys 
225                 230                 235                 240 


Ser Val Pro Lys Arg Glu Tyr Ser Val Lys Glu Ile Leu Lys Leu Asp 
                245                 250                 255     


Ser Asn Pro Ser Lys Arg Lys Asp Ile Tyr Arg Ser Asn Ile Ser Pro 
            260                 265                 270         


Phe Thr Leu Glu Lys Asp Met Asp Gly Phe Arg Lys Asn Gly Ser Pro 
        275                 280                 285             


Asp Met Pro Phe Tyr Pro Arg Val Val Tyr Pro Ile Arg Ala Pro Leu 
    290                 295                 300                 


Pro Glu Asp Phe Leu Lys Ala Ser Leu Ala Tyr Gly Met Glu Arg Pro 
305                 310                 315                 320 


Thr Tyr Ile Thr His Ser Pro Leu Pro Ser Ser Thr Thr Pro Ser Pro 
                325                 330                 335     


Pro Ala Ser Ser Ser Pro Glu Gln Ser Leu Lys Ser Ser Ser Pro His 
            340                 345                 350         


Ser Ser Pro Gly Asn Thr Val Ser Pro Leu Ala Pro Gly Leu Pro Glu 
        355                 360                 365             


His Arg Asp Ser Tyr Ser Tyr Leu Asn Val Ser Tyr Gly Ser Glu Gly 
    370                 375                 380                 


Leu Gly Ser Tyr Pro Gly Tyr Ala Pro Ala Pro His Leu Pro Pro Ala 
385                 390                 395                 400 


Phe Ile Pro Ser Tyr Asn Ala His Tyr Pro Lys Phe Leu Leu Pro Pro 
                405                 410                 415     


Tyr Gly Ile Ser Ser Asn Gly Leu Ser Thr Met Asn Asn Ile Asn Gly 
            420                 425                 430         


Ile Asn Asn Phe Ser Leu Phe Pro Arg Leu Tyr Pro Val Tyr Ser Asn 
        435                 440                 445             


Leu Leu Ser Gly Ser Ser Leu Pro His Pro Met Leu Asn Pro Ala Ser 
    450                 455                 460                 


Leu Pro Ser Ser Leu Pro Thr Asp Gly Ala Arg Arg Leu Leu Pro Pro 
465                 470                 475                 480 


Glu His Pro Lys Glu Val Leu Ile Pro Ala Pro His Ser Ala Phe Ser 
                485                 490                 495     


Leu Thr Gly Ala Ala Ala Ser Met Lys Asp Glu Ser Ser Pro Pro Ser 
            500                 505                 510         


Gly Ser Pro Thr Ala Gly Thr Ala Ala Thr Ser Glu His Val Val Gln 
        515                 520                 525             


Pro Lys Ala Thr Ser Ser Val Met Ala Ala Pro Ser Thr Asp Gly Ala 
    530                 535                 540                 


Met Asn Leu Ile Lys Asn Lys Arg Asn Met Thr Gly Tyr Lys Thr Leu 
545                 550                 555                 560 


Pro Tyr Pro Leu Lys Lys Gln Asn Gly Lys Ile Lys Tyr Glu Cys Asn 
                565                 570                 575     


Val Cys Ala Lys Thr Phe Gly Gln Leu Ser Asn Leu Lys Val His Leu 
            580                 585                 590         


Arg Val His Ser Gly Glu Arg Pro Phe Lys Cys Gln Thr Cys Asn Lys 
        595                 600                 605             


Gly Phe Thr Gln Leu Ala His Leu Gln Lys His Tyr Leu Val His Thr 
    610                 615                 620                 


Gly Glu Lys Pro His Glu Cys Gln Val Cys His Lys Arg Phe Ser Ser 
625                 630                 635                 640 


Thr Ser Asn Leu Lys Thr His Leu Arg Leu His Ser Gly Glu Lys Pro 
                645                 650                 655     


Tyr Gln Cys Lys Val Cys Pro Ala Lys Phe Thr Gln Phe Val His Leu 
            660                 665                 670         


Lys Leu His Lys Arg Leu His Thr Arg Glu Arg Pro His Lys Cys Ala 
        675                 680                 685             


Gln Cys His Lys Ser Tyr Ile His Leu Cys Ser Leu Lys Val His Leu 
    690                 695                 700                 


Lys Gly Asn Cys Pro Ala Gly Pro Ala Ala Gly Leu Pro Leu Glu Asp 
705                 710                 715                 720 


Leu Thr Arg Ile Asn Glu Glu Ile Glu Arg Phe Asp Ile Ser Asp Asn 
                725                 730                 735     


Ala Asp Arg Leu Glu Asp Met Glu Asp Ser Val Asp Val Thr Ser Met 
            740                 745                 750         


Val Glu Lys Glu Ile Leu Ala Val Val Arg Lys Glu Lys Glu Glu Thr 
        755                 760                 765             


Ser Leu Lys Val Ser Leu Gln Arg Asn Met Gly Asn Gly Leu Leu Ser 
    770                 775                 780                 


Ser Gly Cys Ser Leu Tyr Glu Ser Ser Asp Leu Ser Leu Met Lys Leu 
785                 790                 795                 800 


Pro His Ser Asn Pro Leu Pro Leu Val Pro Val Lys Val Lys Gln Glu 
                805                 810                 815     


Thr Val Glu Pro Met Asp Pro 
            820             


