                         SEQUENCE LISTING

<110>  Rinat Neuroscienc Corp.
       Liu, Shu-Hui
       Ho, Wei-Hsien
       Strop, Pavel
       Dorywalska, Magdalena G
       Rajpal, Arvind
       Shelton, David
       Tran, Thomas-Toan
 
<120>  ANTIBODIES SPECIFIC FOR TROP-2 AND THIER USES

<130>  PC71866A

<150>  US 61/559,015
<151>  2011-11-11

<150>  US 61/640,641
<151>  2012-04-30

<150>  US 61/717,288
<151>  2012-10-23

<160>  130   

<170>  PatentIn version 3.5

<210>  1
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  1

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Asn Ile His 
65                  70                  75                  80  


Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  2
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic construct

<400>  2

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Ser Tyr 
            20                  25                  30          


Gly Val His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Asn Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  3

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  4
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  4

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  5
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  5

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  6

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Leu Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  7
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  7

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Asn Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  8
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  8

Asp Ile Leu Leu Thr Gln Ser Pro Ala Ile Leu Ser Val Ser Pro Gly 
1               5                   10                  15      


Glu Arg Val Ser Phe Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Arg Thr Asn Gly Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Ser 
65                  70                  75                  80  


Glu Asp Ile Ala Asp Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  9
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  9

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Val Ser Ser Pro Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Tyr Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  10
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  11
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  11

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  12
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Phe Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  13
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  13

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  14
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  14
gacattgtgc tgacacagtc tcctgcttcc ttagctgtat ctctggggca gagggccacc       60

atctcatgca gggccagcaa aagtgtcagt acatctggct atagttatat gcactggtac      120

caacagaaac caggacagcc acccaaactc ctcatctatc ttgcatccaa cctagaatct      180

ggggtccctg ccaggttcag tggcagtggg tctgggacag acttcaccct caacatccat      240

cctgtggagg aggaggatgc tgcaacctat tactgtcagc acagtaggga gcttccgtac      300

acgttcggag gggggaccaa gctggagatc aaa                                   333


<210>  15
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  15
caggtccaac tgcaggaatc aggtccaggc ctggtgaaac cgtctgaaac cctgagcctg       60

acatgcaccg tgagcggtgg tagtattagc tcttacggcg tccattggat ccgtcaaccg      120

cctggtaaag gtctggaatg gattggcgtg atctggaccg gtggtagcac cgactataac      180

agcgcactga tgagccgcgt gaccatctcg gtagacacgt cgaaaaacca gttcagcctg      240

aaactgagca gcgtgaccgc cgcggatacc gctgtttatt actgcgcacg cgacggggat      300

tatgatcgct acaccatgga ttattggggc cagggtaccc tggtcaccgt ctcctca         357


<210>  16
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  16
gatatcgtaa tgacccaatc tccggattcg ctggcggtat cactgggcga acgtgccacg       60

attaactgcc gtgcaagcaa atcagtgtcg acctccggct acagctatat gcactggtat      120

caacagaaac cgggccagcc gccgaaactg ctgatctatc tggctagcaa cctggagagc      180

ggtgtgcctg atcgctttag tggctccggt agcggtaccg atttcacgct gaccatcagc      240

tccctgcagg cagaagacgt ggccgtgtat tattgtcagc acagccgtga gctgccgtat      300

acttttggcc aggggacaaa actggaaatc aaa                                   333


<210>  17
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  17
caggtccaac tgcaggaatc aggtccaggc ctggtgaaac cgtctgaaac cctgagcctg       60

acatgcaccg tgagcggtgg tagtattagc tcttacggcg tccattggat ccgtcaaccg      120

cctggtaaag gtctggaatg gattggcgtg atctggaccg gtggtagcac cgactataac      180

agcgcactga tgagccgcgt gaccatctcg gtagacacgt cgaaaaacca gttcagcctg      240

aaactgagca gcgtgaccgc cgcggatacc gctgtttatt actgcgcacg cgacggggat      300

tatgatcgct acaccatgga ttattggggc cagggtaccc tggtcaccgt ctcctca         357


<210>  18
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  18
caggtccaac tgcaggaatc aggtccaggc ctggtgaaac cgtctgaaac cctgagcctg       60

acatgcaccg tgagcggtgg tagtattagc tcttacggcg tccattggat ccgtcaaccg      120

cctggtaaag gtctggaatg gattggcgtg atctggacca gtggtgtgac cgactataac      180

agcgcactga tgggccgcgt gaccatctcg gtagacacgt cgaaaaacca gttcagcctg      240

aaactgagca gcgtgaccgc cgcggatacc gctgtttatt actgcgcacg cgacggggat      300

tatgatcgct acaccatgga ttattggggc cagggtaccc tggtcaccgt ctcctca         357


<210>  19
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  19
gatatcgtaa tgacccaatc tccggattcg ctggcggtat cactgggcga acgtgccacg       60

attaactgcc gtgcaagcaa atcagtgtcg acctccttgt acagctatat gcactggtat      120

caacagaaac cgggccagcc gccgaaactg ctgatctatc tggctagcaa cctggagagc      180

ggtgtgcctg atcgctttag tggctccggt agcggtaccg atttcacgct gaccatcagc      240

tccctgcagg cagaagacgt ggccgtgtat tattgtcagc acagccgtga gctgccgtat      300

acttttggcc aggggacaaa actggaaatc aaa                                   333


<210>  20
<211>  333
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  20
gatatcgtaa tgacccaatc tccggattcg ctggcggtat cactgggcga acgtgccacg       60

attaactgcc gtgcaagcaa atcagtgtcg acctccaatt acagctatat gcactggtat      120

caacagaaac cgggccagcc gccgaaactg ctgatctatc tggctagcaa cctggagagc      180

ggtgtgcctg atcgctttag tggctccggt agcggtaccg atttcacgct gaccatcagc      240

tccctgcagg cagaagacgt ggccgtgtat tattgtcagc acagccgtga gctgccgtat      300

acttttggcc aggggacaaa actggaaatc aaa                                   333


<210>  21
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  21
gacatcttgc tgactcagtc tccagccatc ctgtctgtga gtccaggaga aagagtcagt       60

ttctcctgca gggccagtca gaccattggc acaagcatac actggtatca gcaaagaaca      120

aatggttctc caaggcttct cataaagtat gcttctgagt ctatctctgg gatcccttcc      180

aggtttagtg gcagtggatc agggacagat tttactctta gcatcaacag tgtggagtct      240

gaagatattg cagattatta ctgtcaacaa agtaatagct ggccattcac gttcggctcg      300

gggaccaagc tggaaataaa a                                                321


<210>  22
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  22
caggtccaac tgcagcagcc tggggctgag ctggtgaggc ctggggcttc agtgaagctg       60

tcctgcaagg cttctggcta caccttcacc agctactgga taaactgggt gaagcagagg      120

cctggacatg gccttgagtg gatcggaaat atttatcctt ctgatagtta ttctaactac      180

aatcaaaagt tcaaggacaa ggccacattg actgtagaca aatcctccag cacagcctac      240

atgcaggtca gcagcccgac atctgaggac tctgcggtct attactgtac gtacggtagt      300

agctttgact actggggcca aggcaccacg gtcaccgtct cctca                      345


<210>  23
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  23
gagatcgtgc tgacccaaag tccagccacc ctttccctgt ctccaggcga acgcgcaacc       60

ctgagctgcc gcgcttctca gaccattggt acctccattc attggtatca gcagaagccc      120

ggccaagccc cgcgtctgct gatctattac gcctcagaaa gtatttcagg catccccgct      180

cgcttctccg gctccggcag cggaaccgac ttcacactta caatctctag tttggagcca      240

gaagacttcg ccgtttacta ctgtcagcag tctaacagct ggccatttac ctttggccag      300

ggcacgaagc tggaaatcaa g                                                321


<210>  24
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  24
caggtgcagt tggttcagag cggcgcggaa gtcaagaaac ccggcgcctc cgtgaaagtg       60

agctgcaaag cgagcggcta caccttcacc agttattgga ttaactgggt gcgccaggcc      120

ccaggccagg ggctggagtg gatgggaaac atctacccat ctgactctta cagcaactat      180

aatcagaaat ttaaggatcg cgtaacaatg acccgtgaca ccagcaccag cactgtttac      240

atggagctga gttctctgcg ttctgaagat accgccgtgt actactgcgc acgcggttcc      300

agtttcgatt actggggcca ggggaccctg gtcaccgtct cctca                      345


<210>  25
<211>  345
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  25
caggtgcagt tggttcagag cggcgcggaa gtcaagaaac ccggcgcctc cgtgaaagtg       60

agctgcaaag cgagcggcta caccttcacc agttattgga ttaactgggt gcgccaggcc      120

ccaggccagg ggctggagtg gatgggaaac atcttcccat ctgactctta cagcaactat      180

aataagaaat ttaaggatcg cgtaacaatg acccgtgaca ccagcaccag cactgtttac      240

atggagctga gttctctgcg ttctgaagat accgccgtgt actactgcgc acgcggttcc      300

gggttcgatt actggggcca ggggaccctg gtcaccgtct cctca                      345


<210>  26
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  26
gagatcgtgc tgacccaaag tccagccacc ctttccctgt ctccaggcga acgcgcaacc       60

ctgagctgcc gcgcttctca gaccattggt acctccattc attggtatca gcagaagccc      120

ggccaagccc cgcgtctgct gatctattac gcctcagaaa gtatttcagg catccccgct      180

cgcttctccg gctccggcag cggaaccgac ttcacactta caatctctag tttggagcca      240

gaagacttcg ccgtttacta ctgttcgcag tcttttagct ggccatttac ctttggccag      300

ggcacgaagc tggaaatcaa g                                                321


<210>  27
<211>  323
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Ala Arg Gly Pro Gly Leu Ala Pro Pro Pro Leu Arg Leu Pro Leu 
1               5                   10                  15      


Leu Leu Leu Val Leu Ala Ala Val Thr Gly His Thr Ala Ala Gln Asp 
            20                  25                  30          


Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Ser Pro Asp Gly 
        35                  40                  45              


Pro Gly Gly Arg Cys Gln Cys Arg Ala Leu Gly Ser Gly Met Ala Val 
    50                  55                  60                  


Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 
65                  70                  75                  80  


Ser Ala Pro Lys Asn Ala Arg Thr Leu Val Arg Pro Ser Glu His Ala 
                85                  90                  95      


Leu Val Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Pro Glu Gly 
            100                 105                 110         


Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 
        115                 120                 125             


Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Leu Ser Leu Arg 
    130                 135                 140                 


Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 
145                 150                 155                 160 


Arg Pro Thr Ala Gly Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 
                165                 170                 175     


Arg Arg Leu Phe Arg Glu Arg Tyr Arg Leu His Pro Lys Phe Val Ala 
            180                 185                 190         


Ala Val His Tyr Glu Gln Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 
        195                 200                 205             


Thr Ser Gln Lys Ala Ala Gly Asp Val Asp Ile Gly Asp Ala Ala Tyr 
    210                 215                 220                 


Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Gln Gly Arg Gly 
225                 230                 235                 240 


Gly Leu Asp Leu Arg Val Arg Gly Glu Pro Leu Gln Val Glu Arg Thr 
                245                 250                 255     


Leu Ile Tyr Tyr Leu Asp Glu Ile Pro Pro Lys Phe Ser Met Lys Arg 
            260                 265                 270         


Leu Thr Ala Gly Leu Ile Ala Val Ile Val Val Val Val Val Ala Leu 
        275                 280                 285             


Val Ala Gly Met Ala Val Leu Val Ile Thr Asn Arg Arg Lys Ser Gly 
    290                 295                 300                 


Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Lys Glu 
305                 310                 315                 320 


Pro Ser Leu 
            


<210>  28
<211>  317
<212>  PRT
<213>  Mus musculus

<400>  28

Met Ala Arg Gly Leu Asp Leu Ala Pro Leu Leu Leu Leu Leu Leu Ala 
1               5                   10                  15      


Met Ala Thr Arg Phe Cys Thr Ala Gln Ser Asn Cys Thr Cys Pro Thr 
            20                  25                  30          


Asn Lys Met Thr Val Cys Asp Thr Asn Gly Pro Gly Gly Val Cys Gln 
        35                  40                  45              


Cys Arg Ala Met Gly Ser Gln Val Leu Val Asp Cys Ser Thr Leu Thr 
    50                  55                  60                  


Ser Lys Cys Leu Leu Leu Lys Ala Arg Met Ser Ala Arg Lys Ser Gly 
65                  70                  75                  80  


Arg Ser Leu Val Met Pro Ser Glu His Ala Ile Leu Asp Asn Asp Gly 
                85                  90                  95      


Leu Tyr Asp Pro Glu Cys Asp Asp Lys Gly Arg Phe Lys Ala Arg Gln 
            100                 105                 110         


Cys Asn Gln Thr Ser Val Cys Trp Cys Val Asn Ser Val Gly Val Arg 
        115                 120                 125             


Arg Thr Asp Lys Gly Asp Gln Ser Leu Arg Cys Asp Glu Val Val Arg 
    130                 135                 140                 


Thr His His Ile Leu Ile Glu Leu Arg His Arg Pro Thr Asp Arg Ala 
145                 150                 155                 160 


Phe Asn His Ser Asp Leu Asp Ser Glu Leu Arg Arg Leu Phe Gln Glu 
                165                 170                 175     


Arg Tyr Lys Leu His Pro Ser Phe Leu Ser Ala Val His Tyr Glu Glu 
            180                 185                 190         


Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn Ala Ser Gln Lys Gly Leu 
        195                 200                 205             


Arg Asp Val Asp Ile Ala Asp Ala Ala Tyr Tyr Phe Glu Arg Asp Ile 
    210                 215                 220                 


Lys Gly Glu Ser Leu Phe Met Gly Arg Arg Gly Leu Asp Val Gln Val 
225                 230                 235                 240 


Arg Gly Glu Pro Leu His Val Glu Arg Thr Leu Ile Tyr Tyr Leu Asp 
                245                 250                 255     


Glu Lys Pro Pro Gln Phe Ser Met Lys Arg Leu Thr Ala Gly Val Ile 
            260                 265                 270         


Ala Val Ile Ala Val Val Ser Val Ala Val Val Ala Gly Val Val Val 
        275                 280                 285             


Leu Val Val Thr Lys Arg Arg Lys Ser Gly Lys Tyr Lys Lys Val Glu 
    290                 295                 300                 


Leu Lys Glu Leu Gly Glu Met Arg Ser Glu Pro Ser Leu 
305                 310                 315         


<210>  29
<211>  314
<212>  PRT
<213>  Homo sapiens

<400>  29

Met Ala Pro Pro Gln Val Leu Ala Phe Gly Leu Leu Leu Ala Ala Ala 
1               5                   10                  15      


Thr Ala Thr Phe Ala Ala Ala Gln Glu Glu Cys Val Cys Glu Asn Tyr 
            20                  25                  30          


Lys Leu Ala Val Asn Cys Phe Val Asn Asn Asn Arg Gln Cys Gln Cys 
        35                  40                  45              


Thr Ser Val Gly Ala Gln Asn Thr Val Ile Cys Ser Lys Leu Ala Ala 
    50                  55                  60                  


Lys Cys Leu Val Met Lys Ala Glu Met Asn Gly Ser Lys Leu Gly Arg 
65                  70                  75                  80  


Arg Ala Lys Pro Glu Gly Ala Leu Gln Asn Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Glu Ser Gly Leu Phe Lys Ala Lys Gln Cys Asn Gly 
            100                 105                 110         


Thr Ser Thr Cys Trp Cys Val Asn Thr Ala Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Asp Thr Glu Ile Thr Cys Ser Glu Arg Val Arg Thr Tyr Trp Ile 
    130                 135                 140                 


Ile Ile Glu Leu Lys His Lys Ala Arg Glu Lys Pro Tyr Asp Ser Lys 
145                 150                 155                 160 


Ser Leu Arg Thr Ala Leu Gln Lys Glu Ile Thr Thr Arg Tyr Gln Leu 
                165                 170                 175     


Asp Pro Lys Phe Ile Thr Ser Ile Leu Tyr Glu Asn Asn Val Ile Thr 
            180                 185                 190         


Ile Asp Leu Val Gln Asn Ser Ser Gln Lys Thr Gln Asn Asp Val Asp 
        195                 200                 205             


Ile Ala Asp Val Ala Tyr Tyr Phe Glu Lys Asp Val Lys Gly Glu Ser 
    210                 215                 220                 


Leu Phe His Ser Lys Lys Met Asp Leu Thr Val Asn Gly Glu Gln Leu 
225                 230                 235                 240 


Asp Leu Asp Pro Gly Gln Thr Leu Ile Tyr Tyr Val Asp Glu Lys Ala 
                245                 250                 255     


Pro Glu Phe Ser Met Gln Gly Leu Lys Ala Gly Val Ile Ala Val Ile 
            260                 265                 270         


Val Val Val Val Ile Ala Val Val Ala Gly Ile Val Val Leu Val Ile 
        275                 280                 285             


Ser Arg Lys Lys Arg Met Ala Lys Tyr Glu Lys Ala Glu Ile Lys Glu 
    290                 295                 300                 


Met Gly Glu Met His Arg Glu Leu Asn Ala 
305                 310                 


<210>  30
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  30

Ser Tyr Gly Val His 
1               5   


<210>  31
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  31

Gly Phe Ser Leu Thr Ser Tyr 
1               5           


<210>  32
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  32

Gly Phe Ser Leu Thr Ser Tyr Gly Val His 
1               5                   10  


<210>  33
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  33

Val Ile Trp Thr Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  15      


<210>  34
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  34

Trp Thr Gly Gly Ser 
1               5   


<210>  35
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  35

Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  36
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  36

Gly Gly Ser Ile Ser Ser Tyr 
1               5           


<210>  37
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  37

Gly Gly Ser Ile Ser Ser Tyr Gly Val His 
1               5                   10  


<210>  38
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  38

Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met Gly 
1               5                   10                  15      


<210>  39
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  39

Trp Thr Ser Gly Val 
1               5   


<210>  40
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic cosntruct

<400>  40

Ser Tyr Trp Ile Asn 
1               5   


<210>  41
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  41

Gly Tyr Thr Phe Thr Ser Tyr 
1               5           


<210>  42
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  42

Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Asn 
1               5                   10  


<210>  43
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  43

Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  44
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  44

Tyr Pro Ser Asp Ser Tyr 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic cosntruct

<400>  45

Gly Ser Ser Phe Asp Tyr 
1               5       


<210>  46
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  46

Asn Ile Phe Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Lys Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  47
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  47

Phe Pro Ser Asp Ser Tyr 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  48

Gly Ser Gly Phe Asp Tyr 
1               5       


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be G or S

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be S or V

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be G or S

<400>  49

Val Ile Trp Thr Xaa Gly Xaa Thr Asp Tyr Asn Ser Ala Leu Met Xaa 
1               5                   10                  15      


<210>  50
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be G or S

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be S or V

<400>  50

Trp Thr Xaa Gly Xaa 
1               5   


<210>  51
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Y or F

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa can be Q or K

<400>  51

Asn Ile Xaa Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Xaa Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  52
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Y or F

<400>  52

Xaa Pro Ser Asp Ser Tyr 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be G or S

<400>  53

Gly Ser Xaa Phe Asp Tyr 
1               5       


<210>  54
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  54

Arg Ala Ser Lys Ser Val Ser Thr Ser Gly Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  55
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  55

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  56
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  56

Gln His Ser Arg Glu Leu Pro Tyr Thr 
1               5                   


<210>  57
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  57

Arg Ala Ser Lys Ser Val Ser Thr Ser Leu Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  58
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  58

Arg Ala Ser Lys Ser Val Ser Thr Ser Asn Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  59
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  59

Arg Ala Ser Gln Thr Ile Gly Thr Ser Ile His 
1               5                   10      


<210>  60
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  60

Tyr Ala Ser Glu Ser Ile Ser 
1               5           


<210>  61
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  61

Gln Gln Ser Asn Ser Trp Pro Phe Thr 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  62

Ser Gln Ser Phe Ser Trp Pro Phe Thr 
1               5                   


<210>  63
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be G, L, or N

<400>  63

Arg Ala Ser Lys Ser Val Ser Thr Ser Xaa Tyr Ser Tyr Met His 
1               5                   10                  15  


<210>  64
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be Q or S

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be N or F

<400>  64

Xaa Gln Ser Xaa Ser Trp Pro Phe Thr 
1               5                   


<210>  65
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  65

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  66
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  66

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  67
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Phe Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Lys Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 
        115                 120                 125             


Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 
145                 150                 155                 160 


Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 
                165                 170                 175     


Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 
            180                 185                 190         


Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 
        195                 200                 205             


Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  68
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  68

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Phe Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  69
<211>  316
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be Q or L

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be V or R

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be A or P

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be F or L

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be G or L

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be A or L

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa can be T or V

<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be T or G

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be F or H

<220>
<221>  MISC_FEATURE
<222>  (19)..(19)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be E or N

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa can be V or T

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa can be E or P

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa can be N or T

<220>
<221>  MISC_FEATURE
<222>  (30)..(30)
<223>  Xaa can be Y or N

<220>
<221>  MISC_FEATURE
<222>  (33)..(33)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be N or C

<220>
<221>  MISC_FEATURE
<222>  (36)..(36)
<223>  Xaa can be C or S

<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be F or P

<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be V or D

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa can be N or G

<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be N or P

<220>
<221>  MISC_FEATURE
<222>  (41)..(41)
<223>  Xaa can be N or G

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa can be R or G

<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be Q or R

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Xaa can be T or R

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa can be Q or G

<220>
<221>  MISC_FEATURE
<222>  (53)..(53)
<223>  Xaa can be N or M

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be T or A

<220>
<221>  MISC_FEATURE
<222>  (56)..(56)
<223>  Xaa can be I or D

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa can be K or T

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be E or R

<220>
<221>  MISC_FEATURE
<222>  (72)..(72)
<223>  Xaa can be N or S

<220>
<221>  MISC_FEATURE
<222>  (74)..(74)
<223>  Xaa can be S or P

<220>
<221>  MISC_FEATURE
<222>  (76)..(76)
<223>  Xaa can be L or N

<220>
<221>  MISC_FEATURE
<222>  (79)..(79)
<223>  Xaa can be R or T

<220>
<221>  MISC_FEATURE
<222>  (80)..(80)
<223>  Xaa can be A or L

<220>
<221>  MISC_FEATURE
<222>  (81)..(81)
<223>  Xaa can be K or V

<220>
<221>  MISC_FEATURE
<222>  (82)..(82)
<223>  Xaa can be R

<220>
<221>  MISC_FEATURE
<222>  (84)..(84)
<223>  Xaa can be S

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa can be G or H

<220>
<221>  MISC_FEATURE
<222>  (89)..(89)
<223>  Xaa can be Q or V

<220>
<221>  MISC_FEATURE
<222>  (90)..(90)
<223>  Xaa can be N or D

<220>
<221>  MISC_FEATURE
<222>  (101)..(101)
<223>  Xaa can be E or P

<220>
<221>  MISC_FEATURE
<222>  (102)..(102)
<223>  Xaa can be S or E

<220>
<221>  MISC_FEATURE
<222>  (104)..(104)
<223>  Xaa can be L or R

<220>
<221>  MISC_FEATURE
<222>  (112)..(112)
<223>  Xaa can be G or Q

<220>
<221>  MISC_FEATURE
<222>  (115)..(115)
<223>  Xaa can be T or V

<220>
<221>  MISC_FEATURE
<222>  (122)..(122)
<223>  Xaa can be A or V

<220>
<221>  MISC_FEATURE
<222>  (130)..(130)
<223>  Xaa can be G

<220>
<221>  MISC_FEATURE
<222>  (132)..(132)
<223>  Xaa can be T or L

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  Xaa can be E or S

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be T or R

<220>
<221>  MISC_FEATURE
<222>  (137)..(137)
<223>  Xaa can be S or D

<220>
<221>  MISC_FEATURE
<222>  (139)..(139)
<223>  Xaa can be R or L

<220>
<221>  MISC_FEATURE
<222>  (144)..(144)
<223>  Xaa can be W or H

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  Xaa can be A or P

<220>
<221>  MISC_FEATURE
<222>  (154)..(154)
<223>  Xaa can be R or T

<220>
<221>  MISC_FEATURE
<222>  (155)..(155)
<223>  Xaa can be E or A

<220>
<221>  MISC_FEATURE
<222>  (156)..(156)
<223>  Xaa can be K or G

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa can be P or A

<220>
<221>  MISC_FEATURE
<222>  (159)..(159)
<223>  Xaa can be D or N

<220>
<221>  MISC_FEATURE
<222>  (160)..(160)
<223>  Xaa can be S or H

<220>
<221>  MISC_FEATURE
<222>  (161)..(161)
<223>  Xaa can be K or S

<220>
<221>  MISC_FEATURE
<222>  (162)..(162)
<223>  Xaa can be S or D

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  Xaa can be R or D

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  Xaa can be T or A

<220>
<221>  MISC_FEATURE
<222>  (166)..(166)
<223>  Xaa can be A or E

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  Xaa can be Q or R

<220>
<221>  MISC_FEATURE
<222>  (170)..(170)
<223>  Xaa can be E or L

<220>
<221>  MISC_FEATURE
<222>  (171)..(171)
<223>  Xaa can be I or F

<220>
<221>  MISC_FEATURE
<222>  (172)..(172)
<223>  Xaa can be T or R

<220>
<221>  MISC_FEATURE
<222>  (173)..(173)
<223>  Xaa can be T or E

<220>
<221>  MISC_FEATURE
<222>  (176)..(176)
<223>  Xaa can be Q or R

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  Xaa can be D or H

<220>
<221>  MISC_FEATURE
<222>  (183)..(183)
<223>  Xaa can be T or A

<220>
<221>  MISC_FEATURE
<222>  (186)..(186)
<223>  Xaa can be L or H

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa can be N or P

<220>
<221>  MISC_FEATURE
<222>  (191)..(191)
<223>  Xaa can be V or T

<220>
<221>  MISC_FEATURE
<222>  (193)..(193)
<223>  Xaa can be T or Q

<220>
<221>  MISC_FEATURE
<222>  (197)..(197)
<223>  Xaa can be V or R

<220>
<221>  MISC_FEATURE
<222>  (204)..(204)
<223>  Xaa can be T or A

<220>
<221>  MISC_FEATURE
<222>  (205)..(205)
<223>  Xaa can be Q or A

<220>
<221>  MISC_FEATURE
<222>  (206)..(206)
<223>  Xaa can be N or G

<220>
<221>  MISC_FEATURE
<222>  (213)..(213)
<223>  Xaa can be V or A

<220>
<221>  MISC_FEATURE
<222>  (228)..(228)
<223>  Xaa can be H or Q

<220>
<221>  MISC_FEATURE
<222>  (229)..(229)
<223>  Xaa can be S or G

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa can be K or G

<220>
<221>  MISC_FEATURE
<222>  (232)..(232)
<223>  Xaa can be G

<220>
<221>  MISC_FEATURE
<222>  (236)..(236)
<223>  Xaa can be T or R

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa can be N or R

<220>
<221>  MISC_FEATURE
<222>  (241)..(241)
<223>  Xaa can be Q

<220>
<221>  MISC_FEATURE
<222>  (242)..(242)
<223>  Xaa can be L

<220>
<221>  MISC_FEATURE
<222>  (243)..(243)
<223>  Xaa can be D or P

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa can be D or Q

<220>
<221>  MISC_FEATURE
<222>  (246)..(246)
<223>  Xaa can be P or V

<220>
<221>  MISC_FEATURE
<222>  (247)..(247)
<223>  Xaa can be G or E

<220>
<221>  MISC_FEATURE
<222>  (248)..(248)
<223>  Xaa can be Q or R

<220>
<221>  MISC_FEATURE
<222>  (257)..(257)
<223>  Xaa can be K or I

<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  Xaa can be A or P

<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  Xaa can be E or K

<220>
<221>  MISC_FEATURE
<222>  (264)..(264)
<223>  Xaa can be Q or K

<220>
<221>  MISC_FEATURE
<222>  (265)..(265)
<223>  Xaa can be G or R

<220>
<221>  MISC_FEATURE
<222>  (267)..(267)
<223>  Xaa can be K or T

<220>
<221>  MISC_FEATURE
<222>  (286)..(267)
<223>  Xaa can be K or T

<220>
<221>  MISC_FEATURE
<222>  (286)..(286)
<223>  Xaa can be V or A

<220>
<221>  MISC_FEATURE
<222>  (292)..(292)
<223>  Xaa can be R or N

<220>
<221>  MISC_FEATURE
<222>  (296)..(296)
<223>  Xaa can be M or S

<220>
<221>  MISC_FEATURE
<222>  (300)..(300)
<223>  Xaa can be E or K

<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa can be A or V

<220>
<221>  MISC_FEATURE
<222>  (311)..(311)
<223>  Xaa can be H or R

<220>
<221>  MISC_FEATURE
<222>  (314)..(314)
<223>  Xaa can be L or P

<220>
<221>  MISC_FEATURE
<222>  (315)..(315)
<223>  Xaa can be N or S

<220>
<221>  MISC_FEATURE
<222>  (316)..(316)
<223>  Xaa can be A or L

<400>  69

Pro Pro Xaa Xaa Leu Xaa Xaa Xaa Leu Leu Leu Xaa Ala Ala Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Ala Ala Gln Asp Xaa Cys Xaa Cys Xaa Xaa Xaa Lys Leu 
            20                  25                  30          


Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Gln Cys Xaa Ala 
        35                  40                  45              


Leu Gly Ala Xaa Xaa Xaa Val Xaa Cys Ser Xaa Leu Xaa Ala Lys Cys 
    50                  55                  60                  


Leu Leu Leu Lys Ala Xaa Met Xaa Ala Xaa Lys Xaa Ala Arg Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Pro Xaa Glu Xaa Ala Leu Xaa Xaa Asn Asp Gly Leu Tyr Asp 
                85                  90                  95      


Pro Asp Cys Asp Xaa Xaa Gly Xaa Phe Lys Ala Lys Gln Cys Asn Xaa 
            100                 105                 110         


Thr Ser Xaa Cys Trp Cys Val Asn Ser Xaa Gly Val Arg Arg Thr Asp 
        115                 120                 125             


Lys Xaa Asp Xaa Xaa Ile Xaa Cys Xaa Glu Xaa Val Arg Thr His Xaa 
    130                 135                 140                 


Ile Ile Ile Asp Leu Lys His Lys Xaa Xaa Xaa Xaa Xaa Phe Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Leu Xaa Xaa Xaa Leu Xaa Lys Xaa Xaa Xaa Xaa Arg Tyr Xaa 
                165                 170                 175     


Leu Xaa Pro Lys Phe Ile Xaa Ala Ile Xaa Tyr Glu Asn Xaa Xaa Ile 
            180                 185                 190         


Xaa Ile Asp Leu Xaa Gln Asn Ser Ser Gln Lys Xaa Xaa Xaa Asp Val 
        195                 200                 205             


Asp Ile Ala Asp Xaa Ala Tyr Tyr Phe Glu Lys Asp Ile Lys Gly Glu 
    210                 215                 220                 


Ser Leu Phe Xaa Xaa Lys Xaa Xaa Leu Asp Leu Xaa Val Xaa Gly Glu 
225                 230                 235                 240 


Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Thr Leu Ile Tyr Tyr Leu Asp Glu 
                245                 250                 255     


Xaa Xaa Pro Xaa Phe Ser Met Xaa Xaa Leu Xaa Ala Gly Leu Ile Ala 
            260                 265                 270         


Val Ile Val Val Val Val Ile Ala Leu Val Ala Gly Ile Xaa Val Leu 
        275                 280                 285             


Val Ile Ser Xaa Lys Lys Lys Xaa Ala Lys Tyr Xaa Lys Xaa Glu Ile 
    290                 295                 300                 


Lys Glu Leu Gly Glu Leu Xaa Lys Glu Xaa Xaa Xaa 
305                 310                 315     


<210>  70
<211>  323
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be P or L

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be G or D

<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa can be P

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa can be P

<220>
<221>  MISC_FEATURE
<222>  (12)..(12)
<223>  Xaa can be L

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  Xaa can be R

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa can be L

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa can be P

<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa can be A or M

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be V or A

<220>
<221>  MISC_FEATURE
<222>  (26)..(26)
<223>  Xaa can be G or R

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa can be H or F

<220>
<221>  MISC_FEATURE
<222>  (28)..(28)
<223>  Xaa can be T or C

<220>
<221>  MISC_FEATURE
<222>  (29)..(29)
<223>  Xaa can be A or T

<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be D or S

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa can be S or D

<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be P or T

<220>
<221>  MISC_FEATURE
<222>  (47)..(47)
<223>  Xaa can be D or N

<220>
<221>  MISC_FEATURE
<222>  (52)..(52)
<223>  Xaa can be R or V

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be G or Q

<220>
<221>  MISC_FEATURE
<222>  (63)..(63)
<223>  Xaa can be A or L

<220>
<221>  MISC_FEATURE
<222>  (83)..(83)
<223>  Xaa can be P or R

<220>
<221>  MISC_FEATURE
<222>  (85)..(85)
<223>  Xaa can be N or S

<220>
<221>  MISC_FEATURE
<222>  (91)..(91)
<223>  Xaa can be R or M

<220>
<221>  MISC_FEATURE
<222>  (110)..(110)
<223>  Xaa can be P or D

<220>
<221>  MISC_FEATURE
<222>  (111)..(111)
<223>  Xaa can be E or K

<220>
<221>  MISC_FEATURE
<222>  (141)..(141)
<223>  Xaa can be L or Q

<220>
<221>  MISC_FEATURE
<222>  (164)..(164)
<223>  Xaa can be A or D

<220>
<221>  MISC_FEATURE
<222>  (165)..(165)
<223>  Xaa can be G or R

<220>
<221>  MISC_FEATURE
<222>  (181)..(181)
<223>  Xaa can be R or Q

<220>
<221>  MISC_FEATURE
<222>  (189)..(189)
<223>  Xaa can be K or S

<220>
<221>  MISC_FEATURE
<222>  (198)..(198)
<223>  Xaa can be Q or E

<220>
<221>  MISC_FEATURE
<222>  (209)..(209)
<223>  Xaa can be T or A

<220>
<221>  MISC_FEATURE
<222>  (214)..(214)
<223>  Xaa can be A or D

<220>
<221>  MISC_FEATURE
<222>  (214)..(214)
<223>  Xaa can be A or L

<220>
<221>  MISC_FEATURE
<222>  (215)..(215)
<223>  Xaa can be G or R

<220>
<221>  MISC_FEATURE
<222>  (237)..(237)
<223>  Xaa can be Q or M

<220>
<221>  MISC_FEATURE
<222>  (240)..(240)
<223>  Xaa can be G or R

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa can be R or Q

<220>
<221>  MISC_FEATURE
<222>  (252)..(252)
<223>  Xaa can be Q or H

<220>
<221>  MISC_FEATURE
<222>  (264)..(264)
<223>  Xaa can be I or K

<220>
<221>  MISC_FEATURE
<222>  (267)..(267)
<223>  Xaa can be K or Q

<220>
<221>  MISC_FEATURE
<222>  (282)..(282)
<223>  Xaa can be V or A

<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  Xaa can be V or S

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  Xaa can be A or V

<220>
<221>  MISC_FEATURE
<222>  (299)..(299)
<223>  Xaa can be N or K

<220>
<221>  MISC_FEATURE
<222>  (319)..(319)
<223>  Xaa can be K or S

<400>  70

Met Ala Arg Gly Xaa Xaa Leu Ala Pro Xaa Xaa Xaa Xaa Xaa Xaa Leu 
1               5                   10                  15      


Leu Leu Leu Leu Leu Ala Xaa Xaa Thr Xaa Xaa Xaa Xaa Ala Gln Xaa 
            20                  25                  30          


Asn Cys Thr Cys Pro Thr Asn Lys Met Thr Val Cys Xaa Xaa Xaa Gly 
        35                  40                  45              


Pro Gly Gly Xaa Cys Gln Cys Arg Ala Leu Gly Ser Xaa Met Xaa Val 
    50                  55                  60                  


Asp Cys Ser Thr Leu Thr Ser Lys Cys Leu Leu Leu Lys Ala Arg Met 
65                  70                  75                  80  


Ser Ala Xaa Lys Xaa Ala Arg Ser Leu Val Xaa Pro Ser Glu His Ala 
                85                  90                  95      


Ile Leu Asp Asn Asp Gly Leu Tyr Asp Pro Asp Cys Asp Xaa Xaa Gly 
            100                 105                 110         


Arg Phe Lys Ala Arg Gln Cys Asn Gln Thr Ser Val Cys Trp Cys Val 
        115                 120                 125             


Asn Ser Val Gly Val Arg Arg Thr Asp Lys Gly Asp Xaa Ser Leu Arg 
    130                 135                 140                 


Cys Asp Glu Leu Val Arg Thr His His Ile Leu Ile Asp Leu Arg His 
145                 150                 155                 160 


Arg Pro Thr Xaa Xaa Ala Phe Asn His Ser Asp Leu Asp Ala Glu Leu 
                165                 170                 175     


Arg Arg Leu Phe Xaa Glu Arg Tyr Lys Leu His Pro Xaa Phe Leu Ala 
            180                 185                 190         


Ala Val His Tyr Glu Xaa Pro Thr Ile Gln Ile Glu Leu Arg Gln Asn 
        195                 200                 205             


Xaa Ser Gln Lys Ala Xaa Xaa Asp Val Asp Ile Ala Asp Ala Ala Tyr 
    210                 215                 220                 


Tyr Phe Glu Arg Asp Ile Lys Gly Glu Ser Leu Phe Xaa Gly Arg Xaa 
225                 230                 235                 240 


Gly Leu Asp Leu Xaa Val Arg Gly Glu Pro Leu Xaa Val Glu Arg Thr 
                245                 250                 255     


Leu Ile Tyr Tyr Leu Asp Glu Xaa Pro Pro Xaa Phe Ser Met Lys Arg 
            260                 265                 270         


Leu Thr Ala Gly Leu Ile Ala Val Ile Xaa Val Val Xaa Val Ala Leu 
        275                 280                 285             


Val Ala Gly Met Xaa Val Leu Val Ile Thr Xaa Arg Arg Lys Ser Gly 
    290                 295                 300                 


Lys Tyr Lys Lys Val Glu Ile Lys Glu Leu Gly Glu Leu Arg Xaa Glu 
305                 310                 315                 320 


Pro Ser Leu 
            


<210>  71
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  71

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Gly Gly Ser Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  72
<211>  111
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  72

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Ser Thr Ser 
            20                  25                  30          


Gly Tyr Ser Tyr Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln His Ser Arg 
                85                  90                  95      


Glu Leu Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  73
<211>  115
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Ile Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Asn Ile Tyr Pro Ser Asp Ser Tyr Ser Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  74
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  74

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Thr Ile Gly Thr Ser 
            20                  25                  30          


Ile His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Ala Ser Glu Ser Ile Ser Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Asn Ser Trp Pro Phe 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  75
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  75

Leu Leu Gln Gly Gly 
1               5   


<210>  76
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be F or G

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be L or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be T or S

<400>  76

Gly Xaa Ser Xaa Xaa Ser Tyr 
1               5           


<210>  77
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be L or I

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be L or I

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be T or S

<400>  77

Gly Xaa Ser Xaa Xaa Ser Tyr Gly Val His 
1               5                   10  


<210>  78
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  78

Gly Gly Leu Leu Gln Gly Gly 
1               5           


<210>  79
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  79

Leu Leu Gln Gly Ala 
1               5   


<210>  80
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  80

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  81
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  81

Gly Gly Leu Leu Gln Gly Ala 
1               5           


<210>  82
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be M or E

<220>
<221>  Xaa
<222>  (7)..(7)
<223>  Xaa can be E or M

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be M or E

<400>  82

Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  83

Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr 
1               5                   


<210>  84
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<400>  84

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Xaa Xaa Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  85
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be M or E

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be E or M

<400>  85

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Xaa Xaa Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  86
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  86

Xaa Xaa Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr 
1               5                   10      


<210>  87
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa can be E or M

<400>  87

Xaa Xaa Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr 
1               5                   10      


<210>  88
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be G or P

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be A, G, P, or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be A, G, K, P, or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be G, K, or absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be K or absent

<400>  88

Leu Leu Gln Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  89
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (5)..(5)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid or absent

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid or absent

<400>  89

Leu Leu Gln Xaa Xaa Xaa Xaa Xaa 
1               5               


<210>  90
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  90

Leu Leu Gln Gly Pro Gly Lys 
1               5           


<210>  91
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  91

Leu Leu Gln Gly Pro Gly 
1               5       


<210>  92
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  92

Leu Leu Gln Gly Pro Ala 
1               5       


<210>  93
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  93

Leu Leu Gln Gly Pro 
1               5   


<210>  94
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  94

Leu Leu Gln Pro 
1               


<210>  95
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  95

Leu Leu Gln Pro Gly Lys 
1               5       


<210>  96
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  96

Leu Leu Gln Gly Ala Pro Gly Lys 
1               5               


<210>  97
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  97

Leu Leu Gln Gly Ala Pro Gly 
1               5           


<210>  98
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  98

Leu Leu Gln Gly Ala Pro 
1               5       


<210>  99
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  99

Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   


<210>  100
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  100

Asp Tyr Asp Arg Tyr Thr Glu Asp Tyr 
1               5                   


<210>  101
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be any naturally occurring amino acid

<400>  101

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Xaa Xaa Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  102
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct


<220>
<221>  MISC_FEATURE
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (106)..(106)
<223>  Xaa can be E or M

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr 
            20                  25                  30          


Gly Val His Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Val Ile Trp Thr Ser Gly Val Thr Asp Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Xaa Xaa Asp Tyr Asp Arg Tyr Thr Xaa Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  103
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  103

Leu Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  104
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  104

Tyr Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  105
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  105

Phe Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  106
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  106

His Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  107
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  107

Ala Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  108
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  108

Thr Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  109
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  109

Ser Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  110
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  110

Ile Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  111

Arg Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  112
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  112

Val Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  113
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  113

Trp Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  114
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  114

Gln Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  115
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  115

Gly Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  116

Lys Gly Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  117
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  117

Asp Ser Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  118
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  118

Asp Lys Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  119
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  119

Asp His Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  120
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  120

Asp Ala Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  121
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  121

Asp Phe Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  122
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  122

Asp Thr Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  123
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  123

Asp Arg Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  124
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  124

Asp Val Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  125
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  125

Asp Gln Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  126
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  126

Asp Leu Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  127
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  127

Asp Tyr Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  128
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  128

Asp Glu Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  129
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  129

Asp Asn Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


<210>  130
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct

<400>  130

Asp Trp Asp Tyr Asp Arg Tyr Thr Met Asp Tyr 
1               5                   10      


