               SEQUENCE LISTING

<110> Medizinische Hochschule Hannover

<120> Medicament for the treatment of cardiac disease

<130> M1047PCT

<150> EP11188914.3
<151> 2012-11-11

<160> 49

<170> BiSSAP 1.2

<210> 1
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..21
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..21
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO:1 = hsa-miR-21*"

<400> 1
caacaccagu cgaugggcug u                                              21


<210> 2
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 2 = hsa-let-7a"

<400> 2
ugagguagua gguuguauag uu                                             22


<210> 3
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 3 = hsa-miR9*"

<400> 3
auaaagcuag auaaccgaaa gu                                             22


<210> 4
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 4 = hsa-miR-17-5p"

<400> 4
caaagugcuu acagugcagg uag                                            23


<210> 5
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 5 = hsa-miR-21"

<400> 5
uagcuuauca gacugauguu ga                                             22


<210> 6
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..21
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..21
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 6 = hsa-miR-23a"

<400> 6
aucacauugc cagggauuuc c                                              21


<210> 7
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 7 =hsa-miR-30b-3p"

<400> 7
cugggaggug gauguuuacu uc                                             22


<210> 8
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 8 = hsa-miR-129*"

<400> 8
aagcccuuac cccaaaaagc au                                             22


<210> 9
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 9 = hsa-miR-132"

<400> 9
uaacagucua cagccauggu cg                                             22


<210> 10
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 10 =hsa-miR-135a"

<400> 10
uauggcuuuu uauuccuaug uga                                            23


<210> 11
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 11 = hsa-miR-135b"

<400> 11
uauggcuuuu cauuccuaug uga                                            23


<210> 12
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 12 = hsa-miR-138"

<400> 12
agcugguguu gugaaucagg ccg                                            23


<210> 13
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 13 = hsa-miR-181a"

<400> 13
aacauucaac gcugucggug agu                                            23


<210> 14
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 14 =hsa-miR-181b "

<400> 14
aacauucauu gcugucggug ggu                                            23


<210> 15
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 15 = hsa-miR-181c"

<400> 15
aacauucaac cugucgguga gu                                             22


<210> 16
<211> 23
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..23
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..23
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 16 = hsa-miR-181d"

<400> 16
aacauucauu guugucggug ggu                                            23


<210> 17
<211> 21
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..21
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..21
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 17 = rno/mmu-miR-341"

<400> 17
ucggucgauc ggucggucgg u                                              21


<210> 18
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 18 = hsa-miR-374"

<400> 18
auauaauaca accugcuaag ug                                             22


<210> 19
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 19 = hsa-miR-375"

<400> 19
uuuguucguu cggcucgcgu ga                                             22


<210> 20
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 20 = hsa-miR-539"

<400> 20
ggagaaauua uccuuggugu gu                                             22


<210> 21
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 21 = hsa-miR-758"

<400> 21
uuugugaccu gguccacuaa cc                                             22


<210> 22
<211> 22
<212> RNA
<213> Homo sapiens

<220> 
<221> source
<222> 1..22
<223> /organism="Homo sapiens"
      /mol_type="unassigned RNA"

<220> 
<221> ncRNA
<222> 1..22
<223> /ncRNA_class="siRNA"
      /note="SEQ ID NO: 22 = hsa-miR-592"

<400> 22
uugugucaau augcgaugau gu                                             22


<210> 23
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..21
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 23 = anti-hsa-miR-21*"
      /mol_type="unassigned RNA"

<400> 23
acagcccauc gacugguguu g                                              21


<210> 24
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 24 = anti-hsa-let-7a"
      /mol_type="unassigned RNA"

<400> 24
aacuauacaa ccuacuaccu ca                                             22


<210> 25
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:25 = anti-hsa-miR-9*"
      /mol_type="unassigned RNA"

<400> 25
acuuucgguu aucuagcuuu au                                             22


<210> 26
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 26 = anti-hsa-miR-17-5p"
      /mol_type="unassigned RNA"

<400> 26
cuaccugcac uguaagcacu uug                                            23


<210> 27
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 27 = anti-hsa-miR-21"
      /mol_type="unassigned RNA"

<400> 27
ucaacaucag ucugauaagc ua                                             22


<210> 28
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..21
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 28 = anti-hsa-miR-23a"
      /mol_type="unassigned RNA"

<400> 28
ggaaaucccu ggcaauguga u                                              21


<210> 29
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:29 = anti-hsa-miR-30b-3p"
      /mol_type="unassigned RNA"

<400> 29
gaaguaaaca uccaccuccc ag                                             22


<210> 30
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:30 = anti-hsa-miR-129*"
      /mol_type="unassigned RNA"

<400> 30
augcuuuuug ggguaagggc uu                                             22


<210> 31
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:31 = anti-hsa-miR-132"
      /mol_type="unassigned RNA"

<400> 31
cgaccauggc uguagacugu ua                                             22


<210> 32
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 32 = anti-hsa-miR-135a"
      /mol_type="unassigned RNA"

<400> 32
ucacauagga auaaaaagcc aua                                            23


<210> 33
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:33 = anti-hsa-miR-135b"
      /mol_type="unassigned RNA"

<400> 33
ucacauagga augaaaagcc aua                                            23


<210> 34
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:34 = anti-hsa-miR-138"
      /mol_type="unassigned RNA"

<400> 34
cggccugauu cacaacacca gcu                                            23


<210> 35
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:35 = anti-hsa-miR-181a"
      /mol_type="unassigned RNA"

<400> 35
acucaccgac agcguugaau guu                                            23


<210> 36
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:36 = anti-hsa-miR-181b"
      /mol_type="unassigned RNA"

<400> 36
acccaccgac agcaaugaau guu                                            23


<210> 37
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:37 = anti-hsa-miR-181c"
      /mol_type="unassigned RNA"

<400> 37
acucaccgac agguugaaug uu                                             22


<210> 38
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:38 = anti-hsa-miR-181d"
      /mol_type="unassigned RNA"

<400> 38
acccaccgac aacaaugaug uu                                             22


<210> 39
<211> 21
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..21
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:39 = anti-rno/mmu-miR-341"
      /mol_type="unassigned RNA"

<400> 39
accgaccgac cgaucgaccg a                                              21


<210> 40
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 40 = anti-hsa-miR-374"
      /mol_type="unassigned RNA"

<400> 40
cacuuagcag guuguauuau au                                             22


<210> 41
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 41 = anti-hsa-miR-375"
      /mol_type="unassigned RNA"

<400> 41
ucacgcgagc cgaacgaaca aa                                             22


<210> 42
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:42 = anti-hsa-miR-539"
      /mol_type="unassigned RNA"

<400> 42
acacaccaag gauaauuucu cc                                             22


<210> 43
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 43 = anti-hsa-miR-758"
      /mol_type="unassigned RNA"

<400> 43
gguuagugga ccaggucaca aa                                             22


<210> 44
<211> 22
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..22
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 44 = anti-hsa-miR-592"
      /mol_type="unassigned RNA"

<400> 44
acaucaucgc auauugacac aa                                             22


<210> 45
<211> 20
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..20
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:45 = primer for rno-U6"
      /mol_type="unassigned RNA"

<400> 45
cgcaaauucg ugaagcguuc                                                20


<210> 46
<211> 23
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..23
<223> /organism="Artificial sequence"
      /note="SEQ ID NO:46 = primer for RNU43"
      /mol_type="unassigned RNA"

<400> 46
cuuauugacg ggcggacaga aac                                            23


<210> 47
<211> 24
<212> RNA
<213> Artificial sequence

<220> 
<221> source
<222> 1..24
<223> /organism="Artificial sequence"
      /note="SEQ ID NO: 47 = primer for U1"
      /mol_type="unassigned RNA"

<400> 47
cgacugcaua auuuguggua gugg                                           24


<210> 48
<211> 92
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..92
<223> /organism="Artificial Sequence"
      /note="pre-miR-21*"
      /mol_type="unassigned RNA"

<400> 48
uguaccaccu ugucggauag cuuaucagac ugauguugac uguugaaucu cauggcaaca     60

gcagucgaug ggcugucuga cauuuuggua uc                                   92


<210> 49
<211> 72
<212> RNA
<213> Artificial Sequence

<220> 
<221> source
<222> 1..72
<223> /organism="Artificial Sequence"
      /note="pre-miR-21"
      /mol_type="unassigned RNA"

<400> 49
ugucggguag cuuaucagac ugauguugac uguugaaucu cauggcaaca ccagucgaug     60

ggcugucuga ca                                                         72


