                         SEQUENCE LISTING

<110>  SANOFI
 
<120>  DIACYLGLYCEROL LIPASE AND USES THEREOF

<130>  FR2011-070

<160>  59    

<170>  PatentIn version 3.3

<210>  1
<211>  315
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Arg Ala Gly Gln Gln Leu Ala Ser Met Leu Arg Trp Thr Arg Ala 
1               5                   10                  15      


Trp Arg Leu Pro Arg Glu Gly Leu Gly Pro His Gly Pro Ser Phe Ala 
            20                  25                  30          


Arg Val Pro Val Ala Pro Ser Ser Ser Ser Gly Gly Arg Gly Gly Ala 
        35                  40                  45              


Glu Pro Arg Pro Leu Pro Leu Ser Tyr Arg Leu Leu Asp Gly Glu Ala 
    50                  55                  60                  


Ala Leu Pro Ala Val Val Phe Leu His Gly Leu Phe Gly Ser Lys Thr 
65                  70                  75                  80  


Asn Phe Asn Ser Ile Ala Lys Ile Leu Ala Gln Gln Thr Gly Arg Arg 
                85                  90                  95      


Val Leu Thr Val Asp Ala Arg Asn His Gly Asp Ser Pro His Ser Pro 
            100                 105                 110         


Asp Met Ser Tyr Glu Ile Met Ser Gln Asp Leu Gln Asp Leu Leu Pro 
        115                 120                 125             


Gln Leu Gly Leu Val Pro Cys Val Val Val Gly His Ser Met Gly Gly 
    130                 135                 140                 


Lys Thr Ala Met Leu Leu Ala Leu Gln Arg Pro Glu Leu Val Glu Arg 
145                 150                 155                 160 


Leu Ile Ala Val Asp Ile Ser Pro Val Glu Ser Thr Gly Val Ser His 
                165                 170                 175     


Phe Ala Thr Tyr Val Ala Ala Met Arg Ala Ile Asn Ile Ala Asp Glu 
            180                 185                 190         


Leu Pro Arg Ser Arg Ala Arg Lys Leu Ala Asp Glu Gln Leu Ser Ser 
        195                 200                 205             


Val Ile Gln Asp Met Ala Val Arg Gln His Leu Leu Thr Asn Leu Val 
    210                 215                 220                 


Glu Val Asp Gly Arg Phe Val Trp Arg Val Asn Leu Asp Ala Leu Thr 
225                 230                 235                 240 


Gln His Leu Asp Lys Ile Leu Ala Phe Pro Gln Arg Gln Glu Ser Tyr 
                245                 250                 255     


Leu Gly Pro Thr Leu Phe Leu Leu Gly Gly Asn Ser Gln Phe Val His 
            260                 265                 270         


Pro Ser His His Pro Glu Ile Met Arg Leu Phe Pro Arg Ala Gln Met 
        275                 280                 285             


Gln Thr Val Pro Asn Ala Gly His Trp Ile His Ala Asp Arg Pro Gln 
    290                 295                 300                 


Asp Phe Ile Ala Ala Ile Arg Gly Phe Leu Val 
305                 310                 315 


<210>  2
<211>  270
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (94)..(98)
<223>  lipase motif

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  amino acid of the catalytic triad

<220>
<221>  MISC_FEATURE
<222>  (192)..(192)
<223>  amino acid of the catalytic triad

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  amino acid of the catalytic triad

<400>  2

Met Gly Ala Glu Pro Arg Pro Leu Pro Leu Ser Tyr Arg Leu Leu Asp 
1               5                   10                  15      


Gly Glu Ala Ala Leu Pro Ala Val Val Phe Leu His Gly Leu Phe Gly 
            20                  25                  30          


Ser Lys Thr Asn Phe Asn Ser Ile Ala Lys Ile Leu Ala Gln Gln Thr 
        35                  40                  45              


Gly Arg Arg Val Leu Thr Val Asp Ala Arg Asn His Gly Asp Ser Pro 
    50                  55                  60                  


His Ser Pro Asp Met Ser Tyr Glu Ile Met Ser Gln Asp Leu Gln Asp 
65                  70                  75                  80  


Leu Leu Pro Gln Leu Gly Leu Val Pro Cys Val Val Val Gly His Ser 
                85                  90                  95      


Met Gly Gly Lys Thr Ala Met Leu Leu Ala Leu Gln Arg Pro Glu Leu 
            100                 105                 110         


Val Glu Arg Leu Ile Ala Val Asp Ile Ser Pro Val Glu Ser Thr Gly 
        115                 120                 125             


Val Ser His Phe Ala Thr Tyr Val Ala Ala Met Arg Ala Ile Asn Ile 
    130                 135                 140                 


Ala Asp Glu Leu Pro Arg Ser Arg Ala Arg Lys Leu Ala Asp Glu Gln 
145                 150                 155                 160 


Leu Ser Ser Val Ile Gln Asp Met Ala Val Arg Gln His Leu Leu Thr 
                165                 170                 175     


Asn Leu Val Glu Val Asp Gly Arg Phe Val Trp Arg Val Asn Leu Asp 
            180                 185                 190         


Ala Leu Thr Gln His Leu Asp Lys Ile Leu Ala Phe Pro Gln Arg Gln 
        195                 200                 205             


Glu Ser Tyr Leu Gly Pro Thr Leu Phe Leu Leu Gly Gly Asn Ser Gln 
    210                 215                 220                 


Phe Val His Pro Ser His His Pro Glu Ile Met Arg Leu Phe Pro Arg 
225                 230                 235                 240 


Ala Gln Met Gln Thr Val Pro Asn Ala Gly His Trp Ile His Ala Asp 
                245                 250                 255     


Arg Pro Gln Asp Phe Ile Ala Ala Ile Arg Gly Phe Leu Val 
            260                 265                 270 


<210>  3
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Ser Gly Gly Arg Gly Gly Ala Glu Pro Arg Pro Leu Pro Leu Ser 
1               5                   10                  15      


Tyr Arg Leu Leu Asp Gly Glu Ala Ala Leu Pro Ala Val Val Phe Leu 
            20                  25                  30          


His Gly Leu Phe Gly Ser Lys Thr Asn Phe Asn Ser Ile Ala Lys Ile 
        35                  40                  45              


Leu Ala Gln Gln Thr Gly Arg Arg Val Leu Thr Val Asp Ala Arg Asn 
    50                  55                  60                  


His Gly Asp Ser Pro His Ser Pro Asp Met Ser Tyr Glu Ile Met Ser 
65                  70                  75                  80  


Gln Asp Leu Gln Asp Leu Leu Pro Gln Leu Gly Leu Val Pro Cys Val 
                85                  90                  95      


Val Val Gly His Ser Met Gly Gly Lys Thr Ala Met Leu Leu Ala Leu 
            100                 105                 110         


Gln Arg Pro Glu Leu Val Glu Arg Leu Ile Ala Val Asp Ile Ser Pro 
        115                 120                 125             


Val Glu Ser Thr Gly Val Ser His Phe Ala Thr Tyr Val Ala Ala Met 
    130                 135                 140                 


Arg Ala Ile Asn Ile Ala Asp Glu Leu Pro Arg Ser Arg Ala Arg Lys 
145                 150                 155                 160 


Leu Ala Asp Glu Gln Leu Ser Ser Val Ile Gln Asp Met Ala Val Arg 
                165                 170                 175     


Gln His Leu Leu Thr Asn Leu Val Glu Val Asp Gly Arg Phe Val Trp 
            180                 185                 190         


Arg Val Asn Leu Asp Ala Leu Thr Gln His Leu Asp Lys Ile Leu Ala 
        195                 200                 205             


Phe Pro Gln Arg Gln Glu Ser Tyr Leu Gly Pro Thr Leu Phe Leu Leu 
    210                 215                 220                 


Gly Gly Asn Ser Gln Phe Val His Pro Ser His His Pro Glu Ile Met 
225                 230                 235                 240 


Arg Leu Phe Pro Arg Ala Gln Met Gln Thr Val Pro Asn Ala Gly His 
                245                 250                 255     


Trp Ile His Ala Asp Arg Pro Gln Asp Phe Ile Ala Ala Ile Arg Gly 
            260                 265                 270         


Phe Leu Val 
        275 


<210>  4
<211>  285
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Ala Arg Val Pro Val Ala Pro Ser Ser Ser Ser Gly Gly Arg Gly 
1               5                   10                  15      


Gly Ala Glu Pro Arg Pro Leu Pro Leu Ser Tyr Arg Leu Leu Asp Gly 
            20                  25                  30          


Glu Ala Ala Leu Pro Ala Val Val Phe Leu His Gly Leu Phe Gly Ser 
        35                  40                  45              


Lys Thr Asn Phe Asn Ser Ile Ala Lys Ile Leu Ala Gln Gln Thr Gly 
    50                  55                  60                  


Arg Arg Val Leu Thr Val Asp Ala Arg Asn His Gly Asp Ser Pro His 
65                  70                  75                  80  


Ser Pro Asp Met Ser Tyr Glu Ile Met Ser Gln Asp Leu Gln Asp Leu 
                85                  90                  95      


Leu Pro Gln Leu Gly Leu Val Pro Cys Val Val Val Gly His Ser Met 
            100                 105                 110         


Gly Gly Lys Thr Ala Met Leu Leu Ala Leu Gln Arg Pro Glu Leu Val 
        115                 120                 125             


Glu Arg Leu Ile Ala Val Asp Ile Ser Pro Val Glu Ser Thr Gly Val 
    130                 135                 140                 


Ser His Phe Ala Thr Tyr Val Ala Ala Met Arg Ala Ile Asn Ile Ala 
145                 150                 155                 160 


Asp Glu Leu Pro Arg Ser Arg Ala Arg Lys Leu Ala Asp Glu Gln Leu 
                165                 170                 175     


Ser Ser Val Ile Gln Asp Met Ala Val Arg Gln His Leu Leu Thr Asn 
            180                 185                 190         


Leu Val Glu Val Asp Gly Arg Phe Val Trp Arg Val Asn Leu Asp Ala 
        195                 200                 205             


Leu Thr Gln His Leu Asp Lys Ile Leu Ala Phe Pro Gln Arg Gln Glu 
    210                 215                 220                 


Ser Tyr Leu Gly Pro Thr Leu Phe Leu Leu Gly Gly Asn Ser Gln Phe 
225                 230                 235                 240 


Val His Pro Ser His His Pro Glu Ile Met Arg Leu Phe Pro Arg Ala 
                245                 250                 255     


Gln Met Gln Thr Val Pro Asn Ala Gly His Trp Ile His Ala Asp Arg 
            260                 265                 270         


Pro Gln Asp Phe Ile Ala Ala Ile Arg Gly Phe Leu Val 
        275                 280                 285 


<210>  5
<211>  6355
<212>  DNA
<213>  Artificial

<220>
<223>  p4216 plasmid


<220>
<221>  misc_feature
<222>  (742)..(879)
<223>  sequence encoding the MTS

<220>
<221>  misc_feature
<222>  (880)..(1686)
<223>  sequence encoding the mature isoform

<400>  5
gttaggcgtt ttgcgctgct tcgcgatgta cgggccagat atacgcgttg acattgatta     60

ttgactagtt attaatagta atcaattacg gggtcattag ttcatagccc atatatggag    120

ttccgcgtta cataacttac ggtaaatggc ccgcctggct gaccgcccaa cgacccccgc    180

ccattgacgt caataatgac gtatgttccc atagtaacgc caatagggac tttccattga    240

cgtcaatggg tggagtattt acggtaaact gcccacttgg cagtacatca agtgtatcat    300

atgccaagta cgccccctat tgacgtcaat gacggtaaat ggcccgcctg gcattatgcc    360

cagtacatga ccttatggga ctttcctact tggcagtaca tctacgtatt agtcatcgct    420

attaccatgg tgatgcggtt ttggcagtac atcaatgggc gtggatagcg gtttgactca    480

cggggatttc caagtctcca ccccattgac gtcaatggga gtttgttttg gcaccaaaat    540

caacgggact ttccaaaatg tcgtaacaac tccgccccat tgacgcaaat gggcggtagg    600

cgtgtacggt gggaggtcta tataagcaga gctcgtttag tgaaccgtca gatcgcctgg    660

agacgccatc cacgctgttt tgacctccat agaagacacc gggaccgatc cagcctccgg    720

actctagagg atcgaaccct tatgcgagcc ggccaacagc ttgcaagcat gctccgctgg    780

acccgagcct ggaggctccc gcgtgaggga ctcggccccc acggccctag cttcgcgagg    840

gtgcctgtcg cacccagcag cagcagcggc ggccgagggg gcgccgagcc gaggccgctt    900

ccgctttcct acaggcttct ggacggggag gcagccctcc cggccgtcgt ctttttgcac    960

gggctcttcg gcagcaaaac taacttcaac tccatcgcca agatcttggc ccagcagaca   1020

ggccgtaggg tgctgacggt ggatgctcgt aaccacggtg acagccccca cagcccagac   1080

atgagctacg agatcatgag ccaggacctg caggaccttc tgccccagct gggcctggtg   1140

ccctgcgtcg tcgttggcca cagcatggga ggaaagacag ccatgctgct ggcactacag   1200

aggccagagc tggtggaacg tctcattgct gtagatatca gcccagtgga aagcacaggt   1260

gtctcccact ttgcaaccta tgtggcagcc atgagggcca tcaacatcgc agatgagctg   1320

ccccgctccc gtgcccgaaa actggcggat gaacagctca gttctgtcat ccaggacatg   1380

gccgtgcggc agcacctgct cactaacctg gtagaggtag acgggcgctt cgtgtggagg   1440

gtgaacttgg atgccctgac ccagcaccta gacaagatct tggctttccc acagaggcag   1500

gagtcctacc tcgggccaac actctttctc cttggtggaa actcccagtt cgtgcatccc   1560

agccaccacc ctgagattat gcggctcttc cctcgggccc agatgcagac ggtgccgaac   1620

gctggccact ggatccacgc tgaccgccca caggacttca tagctgccat ccgaggcttc   1680

ctggtctaaa agggttcgat ccctaccggt tagtaatgag tttaaacggg ggaggctaac   1740

tgaaacacgg aaggagacaa taccggaagg aacccgcgct atgacggcaa taaaaagaca   1800

gaataaaacg cacgggtgtt gggtcgtttg ttcataaacg cggggttcgg tcccagggct   1860

ggcactctgt cgatacccca ccgagacccc attggggcca atacgcccgc gtttcttcct   1920

tttccccacc ccacccccca agttcgggtg aaggcccagg gctcgcagcc aacgtcgggg   1980

cggcaggccc tgccatagca gatctgcgca gctggggctc tagggggtat ccccacgcgc   2040

cctgtagcgg cgcattaagc gcggcgggtg tggtggttac gcgcagcgtg accgctacac   2100

ttgccagcgc cctagcgccc gctcctttcg ctttcttccc ttcctttctc gccacgttcg   2160

ccggctttcc ccgtcaagct ctaaatcggg gcatcccttt agggttccga tttagtgctt   2220

tacggcacct cgaccccaaa aaacttgatt agggtgatgg ttcacgtagt gggccatcgc   2280

cctgatagac ggtttttcgc cctttgacgt tggagtccac gttctttaat agtggactct   2340

tgttccaaac tggaacaaca ctcaacccta tctcggtcta ttcttttgat ttataaggga   2400

ttttggggat ttcggcctat tggttaaaaa atgagctgat ttaacaaaaa tttaacgcga   2460

attaattctg tggaatgtgt gtcagttagg gtgtggaaag tccccaggct ccccagcagg   2520

cagaagtatg caaagcatgc atctcaatta gtcagcaacc aggtgtggaa agtccccagg   2580

ctccccagca ggcagaagta tgcaaagcat gcatctcaat tagtcagcaa ccatagtccc   2640

gcccctaact ccgcccatcc cgcccctaac tccgcccagt tccgcccatt ctccgcccca   2700

tggctgacta atttttttta tttatgcaga ggccgaggcc gcctctgcct ctgagctatt   2760

ccagaagtag tgaggaggct tttttggagg cctaggcttt tgcaaaaagc tcccgggagc   2820

ttgtatatcc attttcggat ctgatcaaga gacaggatga ggatcgtttc gcatgattga   2880

acaagatgga ttgcacgcag gttctccggc cgcttgggtg gagaggctat tcggctatga   2940

ctgggcacaa cagacaatcg gctgctctga tgccgccgtg ttccggctgt cagcgcaggg   3000

gcgcccggtt ctttttgtca agaccgacct gtccggtgcc ctgaatgaac tgcaggacga   3060

ggcagcgcgg ctatcgtggc tggccacgac gggcgttcct tgcgcagctg tgctcgacgt   3120

tgtcactgaa gcgggaaggg actggctgct attgggcgaa gtgccggggc aggatctcct   3180

gtcatctcac cttgctcctg ccgagaaagt atccatcatg gctgatgcaa tgcggcggct   3240

gcatacgctt gatccggcta cctgcccatt cgaccaccaa gcgaaacatc gcatcgagcg   3300

agcacgtact cggatggaag ccggtcttgt cgatcaggat gatctggacg aagagcatca   3360

ggggctcgcg ccagccgaac tgttcgccag gctcaaggcg cgcatgcccg acggcgagga   3420

tctcgtcgtg acccatggcg atgcctgctt gccgaatatc atggtggaaa atggccgctt   3480

ttctggattc atcgactgtg gccggctggg tgtggcggac cgctatcagg acatagcgtt   3540

ggctacccgt gatattgctg aagagcttgg cggcgaatgg gctgaccgct tcctcgtgct   3600

ttacggtatc gccgctcccg attcgcagcg catcgccttc tatcgccttc ttgacgagtt   3660

cttctgagcg ggactctggg gttcgcgaaa tgaccgacca agcgacgccc aacctgccat   3720

cacgagattt cgattccacc gccgccttct atgaaaggtt gggcttcgga atcgttttcc   3780

gggacgccgg ctggatgatc ctccagcgcg gggatctcat gctggagttc ttcgcccacc   3840

ccaacttgtt tattgcagct tataatggtt acaaataaag caatagcatc acaaatttca   3900

caaataaagc atttttttca ctgcattcta gttgtggttt gtccaaactc atcaatgtat   3960

cttatcatgt ctgtataccg tcgacctcta gctagagctt ggcgtaatca tggtcatagc   4020

tgtttcctgt gtgaaattgt tatccgctca caattccaca caacatacga gccggaagca   4080

taaagtgtaa agcctggggt gcctaatgag tgagctaact cacattaatt gcgttgcgct   4140

cactgcccgc tttccagtcg ggaaacctgt cgtgccagct gcattaatga atcggccaac   4200

gcgcggggag aggcggtttg cgtattgggc gctcttccgc ttcctcgctc actgactcgc   4260

tgcgctcggt cgttcggctg cggcgagcgg tatcagctca ctcaaaggcg gtaatacggt   4320

tatccacaga atcaggggat aacgcaggaa agaacatgtg agcaaaaggc cagcaaaagg   4380

ccaggaaccg taaaaaggcc gcgttgctgg cgtttttcca taggctccgc ccccctgacg   4440

agcatcacaa aaatcgacgc tcaagtcaga ggtggcgaaa cccgacagga ctataaagat   4500

accaggcgtt tccccctgga agctccctcg tgcgctctcc tgttccgacc ctgccgctta   4560

ccggatacct gtccgccttt ctcccttcgg gaagcgtggc gctttctcaa tgctcacgct   4620

gtaggtatct cagttcggtg taggtcgttc gctccaagct gggctgtgtg cacgaacccc   4680

ccgttcagcc cgaccgctgc gccttatccg gtaactatcg tcttgagtcc aacccggtaa   4740

gacacgactt atcgccactg gcagcagcca ctggtaacag gattagcaga gcgaggtatg   4800

taggcggtgc tacagagttc ttgaagtggt ggcctaacta cggctacact agaaggacag   4860

tatttggtat ctgcgctctg ctgaagccag ttaccttcgg aaaaagagtt ggtagctctt   4920

gatccggcaa acaaaccacc gctggtagcg gtggtttttt tgtttgcaag cagcagatta   4980

cgcgcagaaa aaaaggatct caagaagatc ctttgatctt ttctacgggg tctgacgctc   5040

agtggaacga aaactcacgt taagggattt tggtcatgag attatcaaaa aggatcttca   5100

cctagatcct tttaaattaa aaatgaagtt ttaaatcaat ctaaagtata tatgagtaaa   5160

cttggtctga cagttaccaa tgcttaatca gtgaggcacc tatctcagcg atctgtctat   5220

ttcgttcatc catagttgcc tgactccccg tcgtgtagat aactacgata cgggagggct   5280

taccatctgg ccccagtgct gcaatgatac cgcgagaccc acgctcaccg gctccagatt   5340

tatcagcaat aaaccagcca gccggaaggg ccgagcgcag aagtggtcct gcaactttat   5400

ccgcctccat ccagtctatt aattgttgcc gggaagctag agtaagtagt tcgccagtta   5460

atagtttgcg caacgttgtt gccattgcta caggcatcgt ggtgtcacgc tcgtcgtttg   5520

gtatggcttc attcagctcc ggttcccaac gatcaaggcg agttacatga tcccccatgt   5580

tgtgcaaaaa agcggttagc tccttcggtc ctccgatcgt tgtcagaagt aagttggccg   5640

cagtgttatc actcatggtt atggcagcac tgcataattc tcttactgtc atgccatccg   5700

taagatgctt ttctgtgact ggtgagtact caaccaagtc attctgagaa tagtgtatgc   5760

ggcgaccgag ttgctcttgc ccggcgtcaa tacgggataa taccgcgcca catagcagaa   5820

ctttaaaagt gctcatcatt ggaaaacgtt cttcggggcg aaaactctca aggatcttac   5880

cgctgttgag atccagttcg atgtaaccca ctcgtgcacc caactgatct tcagcatctt   5940

ttactttcac cagcgtttct gggtgagcaa aaacaggaag gcaaaatgcc gcaaaaaagg   6000

gaataagggc gacacggaaa tgttgaatac tcatactctt cctttttcaa tattattgaa   6060

gcatttatca gggttattgt ctcatgagcg gatacatatt tgaatgtatt tagaaaaata   6120

aacaaatagg ggttccgcgc acatttcccc gaaaagtgcc acctgacgtc gacggatcgg   6180

gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg ccgcatagtt   6240

aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg cgagcaaaat   6300

ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc ttagg        6355


<210>  6
<211>  4938
<212>  DNA
<213>  Artificial

<220>
<223>  p4412 plasmid


<220>
<221>  misc_feature
<222>  (338)..(475)
<223>  sequence encoding the MTS

<220>
<221>  misc_feature
<222>  (476)..(1282)
<223>  sequence encoding the mature isoform

<220>
<221>  misc_feature
<222>  (1441)..(1441)
<223>  n is a, c, g or t

<400>  6
tcgagtgggt ttgaggcgat cacacttctg ttaacgcaga acctaaacgc atctcgactg     60

cacggtgcac caatgcttct ggcgtcaggc agccatcgga agctgtggta tggctgtgca    120

ggtcgtaaat cactgcataa ttcgtgtcgc tcaaggcgca ctcccgttct ggataatgtt    180

ttttgcgccg acatcataac ggttctggca aatattctga aatgagctgt ttcgagctga    240

ctgactgttg cttatattac atcgatagcg tataatgtgt ggaattgtga gcggataaca    300

atttcacaca gtttttcgcg aagaaggaga tatacatatg cgagccggcc aacagcttgc    360

aagcatgctc cgctggaccc gagcctggag gctcccgcgt gagggactcg gcccccacgg    420

ccctagcttc gcgagggtgc ctgtcgcacc cagcagcagc agcggcggcc gagggggcgc    480

cgagccgagg ccgcttccgc tttcctacag gcttctggac ggggaggcag ccctcccggc    540

cgtcgtcttt ttgcacgggc tcttcggcag caaaactaac ttcaactcca tcgccaagat    600

cttggcccag cagacaggcc gtagggtgct gacggtggat gctcgtaacc acggtgacag    660

cccccacagc ccagacatga gctacgagat catgagccag gacctgcagg accttctgcc    720

ccagctgggc ctggtgccct gcgtcgtcgt tggccacagc atgggaggaa agacagccat    780

gctgctggca ctacagaggc cagagctggt ggaacgtctc attgctgtag atatcagccc    840

agtggaaagc acaggtgtct cccactttgc aacctatgtg gcagccatga gggccatcaa    900

catcgcagat gagctgcccc gctcccgtgc ccgaaaactg gcggatgaac agctcagttc    960

tgtcatccag gacatggccg tgcggcagca cctgctcact aacctggtag aggtagacgg   1020

gcgcttcgtg tggagggtga acttggatgc cctgacccag cacctagaca agatcttggc   1080

tttcccacag aggcaggagt cctacctcgg gccaacactc tttctccttg gtggaaactc   1140

ccagttcgtg catcccagcc accaccctga gattatgcgg ctcttccctc gggcccagat   1200

gcagacggtg ccgaacgctg gccactggat ccacgctgac cgcccacagg acttcatagc   1260

tgccatccga ggcttcctgg tctaagcggc cgctccggct gctaacaaag cccgaaagga   1320

agctgagttg gctgctgcca ccgctgagca ataactagca taaccccttg gggcctctaa   1380

acgggtcttg aggggttttt tgctgaaagg aggaactata tccggatgta ccaagcttgg   1440

ncggatcaaa gttttgtcgt ctttccagac gttagtaaat gaattttctg tatgaggttt   1500

tgctaaacaa ctttcaacag tttcagcgga gtgagaatag aaaggaacaa ctaaaggaat   1560

tgcgaataat aattttttca cgttgaaaat ctccaaaaaa aaaggctcca aaaggagcct   1620

ttaattgtat cggtttatca gcttgctttc gaggtgaatt tcttaaacag cttgataccg   1680

atagttgcgc cgacaatgac aacaaccatc gcccacgcat aaccgatata ttcggtcgct   1740

gaggcttgca gggagtcaaa ggccgctttt gcgggatcga tccgcggaag cataaagtgt   1800

aaagcctggg gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc   1860

gctttccagt cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg   1920

agaggcggtt tgcgtattgg gcgccagggt ggtttttctt ttcaccagtg agacgggcaa   1980

cagctgattg cccttcaccg cctggccctg agagagttgc agcaagcggt ccacgctggt   2040

ttgccccagc aggcgaaaat cctgtttgct ggtggttaac ggcgggatat aacatgagct   2100

gtcttcggta tcgtcgtatc ccactaccga gatatccgca ccaacgcgca gcccggactc   2160

ggtaatggcg cgcattgcgc ccagcgccat ctgatcgttg gcaaccagca tcgcagtggg   2220

aacgatgccc tcattcagca tttgcatggt ttgttgaaaa ccggacatgg cactccagtc   2280

gccttcccgt tccgctatcg gctgaatttg attgcgagtg agatatttat gccagccagc   2340

cagacgcaga cgcgccgaga cagaacttaa tgggcccgct aacagcgcga tttgctggtg   2400

acccaatgcg accagatgct ccacgcccag tcgcgtaccg tcttcatggg agaaaataat   2460

actgttgatg ggtgtctggt cagagacatc aagaaataac gccggaacat tagtgcaggc   2520

agcttccaca gcaatggcat cctggtcatc cagcggatag ttaatgatca gcccactgac   2580

gcgttgcgcg agaagattgt gcaccgccgc tttacaggct tcgacgccgc ttcgttctac   2640

catcgacacc accacgctgg cacccagttg atcggcgcga gatttaatcg ccgcgacaat   2700

ttgcgacggc gcgtgcaggg ccagactgga ggtggcaacg ccaatcagca acgactgttt   2760

gcccgccagt tgttgtgcca cgcggttggg aatgtaattc agctccgcca tcgccgcttc   2820

cactttttcc cgcgttttcg cagaaacgtg gctggcctgg ttcaccacgc gggaaacggt   2880

ctgataagag acaccggcat actctgcgac atcgtataac gttactggtt tcacattcac   2940

caccctgaat tgactctctt ccgggcgcta tcatgccata ccgcgaaagg ttttgcgcca   3000

ttcgatctac gccggacgca tcgtggccgc aaaccaaccc ttggcagaac atatccatcg   3060

cgtccgccat ctccagcagc cgcacgcggc gcatctcggg ccgcgttgct ggcgtttttc   3120

cataggctcc gcccccctga cgagcatcac aaaaatcgac gctcaagtca gaggtggcga   3180

aacccgacag gactataaag ataccaggcg tttccccctg gaagctccct cgtgcgctct   3240

cctgttccga ccctgccgct taccggatac ctgtccgcct ttctcccttc gggaagcgtg   3300

gcgctttctc aatgctcacg ctgtaggtat ctcagttcgg tgtaggtcgt tcgctccaag   3360

ctgggctgtg tgcacgaacc ccccgttcag cccgaccgct gcgccttatc cggtaactat   3420

cgtcttgagt ccaacccggt aagacacgac ttatcgccac tggcagcagc cactggtaac   3480

aggattagca gagcgaggta tgtaggcggt gctacagagt tcttgaagtg gtggcctaac   3540

tacggctaca ctagaaggac agtatttggt atctgcgctc tgctgaagcc agttaccttc   3600

ggaaaaagag ttggtagctc ttgatccggc aaacaaacca ccgctggtag cggtggtttt   3660

tttgtttgca agcagcagat tacgcgcaga aaaaaaggat ctcaagaaga tcctttgatc   3720

ttttctacgg ggtctgacgc tcagtggaac gaaaactcac gttaagggat tttggtcatg   3780

agattatcaa aaaggatctt cacctagatc cttttaaatt aaaaatgaag ttttaaatca   3840

atctaaagta tatatgagta aacttggtct gacagttacc aatgcttaat cagtgaggca   3900

cctatctcag cgatctgtct atttcgttca tccatagttg cctgactccc cgtcgtgtag   3960

ataactacga tacgggaggg cttaccatct ggccccagtg ctgcaatgat accgcgagac   4020

ccacgctcac cggctccaga tttatcagca ataaaccagc cagccggaag ggccgagcgc   4080

agaagtggtc ctgcaacttt atccgcctcc atccagtcta ttaattgttg ccgggaagct   4140

agagtaagta gttcgccagt taatagtttg cgcaacgttg ttgccattgc tgcaggcatc   4200

gtggtgtcac gctcgtcgtt tggtatggct tcattcagct ccggttccca acgatcaagg   4260

cgagttacat gatcccccat gttgtgcaaa aaagcggtta gctccttcgg tcctccgatc   4320

gttgtcagaa gtaagttggc cgcagtgtta tcactcatgg ttatggcagc actgcataat   4380

tctcttactg tcatgccatc cgtaagatgc ttttctgtga ctggtgagta ctcaaccaag   4440

tcattctgag aatagtgtat gcggcgaccg agttgctctt gcccggcgtc aacacgggat   4500

aataccgcgc cacatagcag aactttaaaa gtgctcatca ttggaaaacg ttcttcgggg   4560

cgaaaactct caaggatctt accgctgttg agatccagtt cgatgtaacc cactcgtgca   4620

cccaactgat cttcagcatc ttttactttc accagcgttt ctgggtgagc aaaaacagga   4680

aggcaaaatg ccgcaaaaaa gggaataagg gcgacacgga aatgttgaat actcatactc   4740

ttcctttttc aatattattg aagcatttat cagggttatt gtctcatgag cggatacata   4800

tttgaatgta tttagaaaaa taaacaaata ggggttccgc gcacatttcc ccgaaaagtg   4860

ccacctgacg tctaagaaac cattattatc atgacattaa cctataaaaa taggcgtatc   4920

acgaggccct ttcgtccc                                                 4938


<210>  7
<211>  8460
<212>  DNA
<213>  Artificial

<220>
<223>  p4411 plasmid


<220>
<221>  misc_feature
<222>  (1483)..(1620)
<223>  sequence encoding the MTS

<220>
<221>  misc_feature
<222>  (1621)..(2427)
<223>  sequence encoding the mature isoform

<220>
<221>  misc_feature
<222>  (6055)..(6055)
<223>  n is a, c, g or t

<400>  7
ttcaattcaa ttcatcattt tttttttatt cttttttttg atttcggttt ctttgaaatt     60

tttttgattc ggtaatctcc gaacagaagg aagaacgaag gaaggagcac agacttagat    120

tggtatatat acgcatatgt agtgttgaag aaacatgaaa ttgcccagta ttcttaaccc    180

aactgcacag aacaaaaacc tgcaggaaac gaagataaat catgtcgaaa gctacatata    240

aggaacgtgc tgctactcat cctagtcctg ttgctgccaa gctatttaat atcatgcacg    300

aaaagcaaac aaacttgtgt gcttcattgg atgttcgtac caccaaggaa ttactggagt    360

tagttgaagc attaggtccc aaaatttgtt tactaaaaac acatgtggat atcttgactg    420

atttttccat ggagggcaca gttaagccgc taaaggcatt atccgccaag tacaattttt    480

tactcttcga agacagaaaa tttgctgaca ttggtaatac agtcaaattg cagtactctg    540

cgggtgtata cagaatagca gaatgggcag acattacgaa tgcacacggt gtggtgggcc    600

caggtattgt tagcggtttg aagcaggcgg cagaagaagt aacaaaggaa cctagaggcc    660

ttttgatgtt agcagaattg tcatgcaagg gctccctatc tactggagaa tatactaagg    720

gtactgttga cattgcgaag agcgacaaag attttgttat cggctttatt gctcaaagag    780

acatgggtgg aagagatgaa ggttacgatt ggttgattat gacacccggt gtgggtttag    840

atgacaaggg agacgcattg ggtcaacagt atagaaccgt ggatgatgtg gtctctacag    900

gatctgacat tattattgtt ggaagaggac tatttgcaaa gggaagggat gctaaggtag    960

agggtgaacg ttacagaaaa gcaggctggg aagcatattt gagaagatgc ggccagcaaa   1020

actaaaaaac tgtattataa gtaaatgcat gtatactaaa ctcacaaatt agagcttcaa   1080

tttaattata tcagttatta cccgggacgc gtctatactt cggagcactg ttgagcgaag   1140

gctcattaga tatattttct gtcattttcc ttaacccaaa aataagggag agggtccaaa   1200

aagcgctcgg acaactgttg accgtgatcc gaaggactgg ctatacagtg ttcacaaaat   1260

agccaagctg aaaataatgt gtagccttta gctatgttca gttagtttgg catgcctatc   1320

acatataaat agagtgccag tagcgacttt tttcacactc gagatactct tactactgct   1380

ctcttgttgt ttttatcact tcttgtttct tcttggtaaa tagaatatca agctacaaaa   1440

agcatacaat caactatcaa tcagatctaa tattaataaa aaatgcgagc cggccaacag   1500

cttgcaagca tgctccgctg gacccgagcc tggaggctcc cgcgtgaggg actcggcccc   1560

cacggcccta gcttcgcgag ggtgcctgtc gcacccagca gcagcagcgg cggccgaggg   1620

ggcgccgagc cgaggccgct tccgctttcc tacaggcttc tggacgggga ggcagccctc   1680

ccggccgtcg tctttttgca cgggctcttc ggcagcaaaa ctaacttcaa ctccatcgcc   1740

aagatcttgg cccagcagac aggccgtagg gtgctgacgg tggatgctcg taaccacggt   1800

gacagccccc acagcccaga catgagctac gagatcatga gccaggacct gcaggacctt   1860

ctgccccagc tgggcctggt gccctgcgtc gtcgttggcc acagcatggg aggaaagaca   1920

gccatgctgc tggcactaca gaggccagag ctggtggaac gtctcattgc tgtagatatc   1980

agcccagtgg aaagcacagg tgtctcccac tttgcaacct atgtggcagc catgagggcc   2040

atcaacatcg cagatgagct gccccgctcc cgtgcccgaa aactggcgga tgaacagctc   2100

agttctgtca tccaggacat ggccgtgcgg cagcacctgc tcactaacct ggtagaggta   2160

gacgggcgct tcgtgtggag ggtgaacttg gatgccctga cccagcacct agacaagatc   2220

ttggctttcc cacagaggca ggagtcctac ctcgggccaa cactctttct ccttggtgga   2280

aactcccagt tcgtgcatcc cagccaccac cctgagatta tgcggctctt ccctcgggcc   2340

cagatgcaga cggtgccgaa cgctggccac tggatccacg ctgaccgccc acaggacttc   2400

atagctgcca tccgaggctt cctggtctaa gtcgactcta gaggatctcc catgtctcta   2460

ctggtggtgg tgcttctttg gaattattgg aaggtaagga attgccaggt gttgctttct   2520

tatccgaaaa gaaataaatt gaattgaatt gaaatcgata gatcaatttt tttcttttct   2580

ctttccccat cctttacgct aaaataatag tttattttat tttttgaata ttttttattt   2640

atatacgtat atatagacta ttatttactt ttaatagatt attaagattt ttattaaaaa   2700

aaaattcgtc cctcttttta atgcctttta tgcagttttt ttttcccatt cgatatttct   2760

atgttcgggt ttcagcgtat tttaagttta ataactcgaa aattctgcgt ttcgaaaaag   2820

ctctgcctcg cgcgtttcgg tgatgacggt gaaaacctct gacacatgca gctcccggag   2880

acggtcacag cttgtctgta agcggatgcc gggagcagac aagcccgtca gggcgcgtca   2940

gcgggtgttg gcgggtgtcg gggcgcagcc atgacccagt cacgtagcga tagcggagtg   3000

tatactggct taactatgcg gcatcagagc agattgtact gagagtgcac catatgcggt   3060

gtgaaatacc gcacagatgc gtaaggagaa aataccgcat caggcgctct tccgcttcct   3120

cgctcactga ctcgctgcgc tcggtcgttc ggctgcggcg agcggtatca gctcactcaa   3180

aggcggtaat acggttatcc acagaatcag gggataacgc aggaaagaac atgtgagcaa   3240

aaggccagca aaaggccagg aaccgtaaaa aggccgcgtt gctggcgttt ttccataggc   3300

tccgcccccc tgacgagcat cacaaaaatc gacgctcaag tcagaggtgg cgaaacccga   3360

caggactata aagataccag gcgtttcccc ctggaagctc cctcgtgcgc tctcctgttc   3420

cgaccctgcc gcttaccgga tacctgtccg cctttctccc ttcgggaagc gtggcgcttt   3480

ctcatagctc acgctgtagg tatctcagtt cggtgtaggt cgttcgctcc aagctgggct   3540

gtgtgcacga accccccgtt cagcccgacc gctgcgcctt atccggtaac tatcgtcttg   3600

agtccaaccc ggtaagacac gacttatcgc cactggcagc agccactggt aacaggatta   3660

gcagagcgag gtatgtaggc ggtgctacag agttcttgaa gtggtggcct aactacggct   3720

acactagaag gacagtattt ggtatctgcg ctctgctgaa gccagttacc ttcggaaaaa   3780

gagttggtag ctcttgatcc ggcaaacaaa ccaccgctgg tagcggtggt ttttttgttt   3840

gcaagcagca gattacgcgc agaaaaaaag gatctcaaga agatcctttg atcttttcta   3900

cggggtctga cgctcagtgg aacgaaaact cacgttaagg gattttggtc atgagattat   3960

caaaaaggat cttcacctag atccttttaa attaaaaatg aagttttaaa tcaatctaaa   4020

gtatatatga gtaaacttgg tctgacagtt accaatgctt aatcagtgag gcacctatct   4080

cagcgatctg tctatttcgt tcatccatag ttgcctgact ccccgtcgtg tagataacta   4140

cgatacggga gggcttacca tctggcccca gtgctgcaat gataccgcga gacccacgct   4200

caccggctcc agatttatca gcaataaacc agccagccgg aagggccgag cgcagaagtg   4260

gtcctgcaac tttatccgcc tccatccagt ctattaattg ttgccgggaa gctagagtaa   4320

gtagttcgcc agttaatagt ttgcgcaacg ttgttgccat tgctgcaggc atcgtggtgt   4380

cacgctcgtc gtttggtatg gcttcattca gctccggttc ccaacgatca aggcgagtta   4440

catgatcccc catgttgtgc aaaaaagcgg ttagctcctt cggtcctccg atcgttgtca   4500

gaagtaagtt ggccgcagtg ttatcactca tggttatggc agcactgcat aattctctta   4560

ctgtcatgcc atccgtaaga tgcttttctg tgactggtga gtactcaacc aagtcattct   4620

gagaatagtg tatgcggcga ccgagttgct cttgcccggc gtcaacacgg gataataccg   4680

cgccacatag cagaacttta aaagtgctca tcattggaaa acgttcttcg gggcgaaaac   4740

tctcaaggat cttaccgctg ttgagatcca gttcgatgta acccactcgt gcacccaact   4800

gatcttcagc atcttttact ttcaccagcg tttctgggtg agcaaaaaca ggaaggcaaa   4860

atgccgcaaa aaagggaata agggcgacac ggaaatgttg aatactcata ctcttccttt   4920

ttcaatatta ttgaagcatt tatcagggtt attgtctcat gagcggatac atatttgaat   4980

gtatttagaa aaataaacaa ataggggttc cgcgcacatt tccccgaaaa gtgccacctg   5040

acgtctaaga aaccattatt atcatgacat taacctataa aaataggcgt atcacgaggc   5100

cctttcgtct tcaagaattc cacggactat agactatact agtatactcc gtctactgta   5160

cgatacactt ccgctcaggt ccttgtcctt taacgaggcc ttaccactct tttgttactc   5220

tattgatcca gctcagcaaa ggcagtgtga tctaagattc tatcttcgcg atgtagtaaa   5280

actagctaga ccgagaaaga gactagaaat gcaaaaggca cttctacaat ggctgccatc   5340

attattatcc gatgtgacgc tgcatttttt tttttttttt gtacaaatat cataaaaaaa   5400

gagaatcttt ttaagcaagg attttcttaa cttcttcggc gacagcatca ccgacttcgg   5460

tggtactgtt ggaaccacct aaatcaccag ttctgatacc tgcatccaaa acctttttaa   5520

ctgcatcttc aatggcttta ccttcttcag gcaagttcaa tgacaatttc aacatcattg   5580

cagcagacaa gatagtggcg atagggttga ccttattctt tggcaaatct ggagcggaac   5640

catggcatgg ttcgtacaaa ccaaatgcgg tgttcttgtc tggcaaagag gccaaggacg   5700

cagatggcaa caaacccaag gagcctggga taacggaggc ttcatcggag atgatatcac   5760

caaacatgtt gctggtgatt ataataccat ttaggtgggt tgggttctta actaggatca   5820

tggcggcaga atcaatcaat tgatgttgaa ctttcaatgt agggaattcg ttcttgatgg   5880

tttcctccac agtttttctc cataatcttg aagaggccaa aacattagct ttatccaagg   5940

accaaatagg caatggtggc tcatgttgta gggccatgaa agcggccatt cttgtgattc   6000

tttgcacttc tggaacggtg tattgttcac tatcccaagc gacaccatca ccatngtctt   6060

cctttctctt accaaagtaa atacctccca ctaattctct gacaacaacg aagtcagtac   6120

ctttagcaaa ttgtggcttg attggagata agtctaaaag agagtcggat gcaaagttac   6180

atggtcttaa gttggcgtac aattgaagtt ctttacggat ttttagtaaa ccttgttcag   6240

gtctaacact accggtaccc catttaggac cacccacagc acctaacaaa acggcatcaa   6300

ccttcttgga ggcttccagc gcctcatctg gaagtgggac acctgtagca tcgatagcag   6360

caccaccaat taaatgattt tcgaaatcga acttgacatt ggaacgaaca tcagaaatag   6420

ctttaagaac cttaatggct tcggctgtga tttcttgacc aacgtggtca cctggcaaaa   6480

cgacgatctt cttaggggca gacatagggg cagacattac aatggtatat ccttgaaata   6540

tatataaaaa aaaaaaaaaa tgcagcttct caatgatatt cgaatacgct ttgaggagat   6600

acagcctaat atccgacaaa ctgttttaca gatttacgat cgtacttgtt acccatcatt   6660

gaattttgaa catccgaacc tgggagtttt ccctgaaaca gatagtatat ttgaacctgt   6720

ataataatat atagtctagc gctttacgga agacaatgta tgtatttcgg ttcctggaga   6780

aactattgca tctattgcat aggtaatctt gcacgtcgca tccccggttc attttctgcg   6840

tttccatctt gcacttcaat agcatatctt tgttaacgaa gcatctgtgc ttcattttgt   6900

agaacaaaaa tgcaacgcga gagcgctaat ttttcaaaca aagaatctga gctgcatttt   6960

tacagaacag aaatgcaacg cgaaagcgct attttaccaa cgaagaatct gtgcttcatt   7020

tttgtaaaac aaaaatgcaa cgcgagagcg ctaatttttc aaacaaagaa tctgagctgc   7080

atttttacag aacagaaatg caacgcgaga gcgctatttt accaacaaag aatctatact   7140

tcttttttgt tctacaaaaa tgcatcccga gagcgctatt tttctaacaa agcatcttag   7200

attacttttt ttctcctttg tgcgctctat aatgcagtct cttgataact ttttgcactg   7260

taggtccgtt aaggttagaa gaaggctact ttggtgtcta ttttctcttc cataaaaaaa   7320

gcctgactcc acttcccgcg tttactgatt actagcgaag ctgcgggtgc attttttcaa   7380

gataaaggca tccccgatta tattctatac cgatgtggat tgcgcatact ttgtgaacag   7440

aaagtgatag cgttgatgat tcttcattgg tcagaaaatt atgaacggtt tcttctattt   7500

tgtctctata tactacgtat aggaaatgtt tacattttcg tattgttttc gattcactct   7560

atgaatagtt cttactacaa tttttttgtc taaagagtaa tactagagat aaacataaaa   7620

aatgtagagg tcgagtttag atgcaagttc aaggagcgaa aggtggatgg gtaggttata   7680

tagggatata gcacagagat atatagcaaa gagatacttt tgagcaatgt ttgtggaagc   7740

ggtattcgca atattttagt agctcgttac agtccggtgc gtttttggtt ttttgaaagt   7800

gcgtcttcag agcgcttttg gttttcaaaa gcgctctgaa gttcctatac tttctagaga   7860

ataggaactt cggaatagga acttcaaagc gtttccgaaa acgagcgctt ccgaaaatgc   7920

aacgcgagct gcgcacatac agctcactgt tcacgtcgca cctatatctg cgtgttgcct   7980

gtatatatat atacatgaga agaacggcat agtgcgtgtt tatgcttaaa tgcgtactta   8040

tatgcgtcta tttatgtagg atgaaaggta gtctagtacc tcctgtgata ttatcccatt   8100

ccatgcgggg tatcgtatgc ttccttcagc actacccttt agctgttcta tatgctgcca   8160

ctcctcaatt ggattagtct catccttcaa tgctatcatt tcctttgata ttggatcata   8220

tgcatagtac cgagaaacta gtgcgaagta gtgatcaggt attgctgtta tctgatgagt   8280

atacgttgtc ctggccacgg cagaagcacg cttatcgctc caatttccca caacattagt   8340

caactccgtt aggcccttca ttgaaagaaa tgaggtcatc aaatgtcttc caatgtgaga   8400

ttttgggcca ttttttatag caaagattga ataaggcgca tttttcttca aagctagctt   8460


<210>  8
<211>  948
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(138)
<223>  sequence encoding the MTS

<220>
<221>  misc_feature
<222>  (139)..(945)
<223>  sequence encoding the mature isoform

<400>  8
atgcgagccg gccaacagct tgcaagcatg ctccgctgga cccgagcctg gaggctcccg     60

cgtgagggac tcggccccca cggccctagc ttcgcgaggg tgcctgtcgc acccagcagc    120

agcagcggcg gccgaggggg cgccgagccg aggccgcttc cgctttccta caggcttctg    180

gacggggagg cagccctccc ggccgtcgtc tttttgcacg ggctcttcgg cagcaaaact    240

aacttcaact ccatcgccaa gatcttggcc cagcagacag gccgtagggt gctgacggtg    300

gatgctcgta accacggtga cagcccccac agcccagaca tgagctacga gatcatgagc    360

caggacctgc aggaccttct gccccagctg ggcctggtgc cctgcgtcgt cgttggccac    420

agcatgggag gaaagacagc catgctgctg gcactacaga ggccagagct ggtggaacgt    480

ctcattgctg tagatatcag cccagtggaa agcacaggtg tctcccactt tgcaacctat    540

gtggcagcca tgagggccat caacatcgca gatgagctgc cccgctcccg tgcccgaaaa    600

ctggcggatg aacagctcag ttctgtcatc caggacatgg ccgtgcggca gcacctgctc    660

actaacctgg tagaggtaga cgggcgcttc gtgtggaggg tgaacttgga tgccctgacc    720

cagcacctag acaagatctt ggctttccca cagaggcagg agtcctacct cgggccaaca    780

ctctttctcc ttggtggaaa ctcccagttc gtgcatccca gccaccaccc tgagattatg    840

cggctcttcc ctcgggccca gatgcagacg gtgccgaacg ctggccactg gatccacgct    900

gaccgcccac aggacttcat agctgccatc cgaggcttcc tggtctaa                 948


<210>  9
<211>  813
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1)..(810)
<223>  sequence encoding the mature isoform

<400>  9
atgggcgccg agccgaggcc gcttccgctt tcctacaggc ttctggacgg ggaggcagcc     60

ctcccggccg tcgtcttttt gcacgggctc ttcggcagca aaactaactt caactccatc    120

gccaagatct tggcccagca gacaggccgt agggtgctga cggtggatgc tcgtaaccac    180

ggtgacagcc cccacagccc agacatgagc tacgagatca tgagccagga cctgcaggac    240

cttctgcccc agctgggcct ggtgccctgc gtcgtcgttg gccacagcat gggaggaaag    300

acagccatgc tgctggcact acagaggcca gagctggtgg aacgtctcat tgctgtagat    360

atcagcccag tggaaagcac aggtgtctcc cactttgcaa cctatgtggc agccatgagg    420

gccatcaaca tcgcagatga gctgccccgc tcccgtgccc gaaaactggc ggatgaacag    480

ctcagttctg tcatccagga catggccgtg cggcagcacc tgctcactaa cctggtagag    540

gtagacgggc gcttcgtgtg gagggtgaac ttggatgccc tgacccagca cctagacaag    600

atcttggctt tcccacagag gcaggagtcc tacctcgggc caacactctt tctccttggt    660

ggaaactccc agttcgtgca tcccagccac caccctgaga ttatgcggct cttccctcgg    720

gcccagatgc agacggtgcc gaacgctggc cactggatcc acgctgaccg cccacaggac    780

ttcatagctg ccatccgagg cttcctggtc taa                                 813


<210>  10
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  10
gccgccacca tgcgagccgg ccaacag                                         27


<210>  11
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  11
ttagaccagg aagcctcgg                                                  19


<210>  12
<211>  54
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  12
gccgccacca tggactacaa agacgatgac gacaaacgag ccggccaaca gctt           54


<210>  13
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  13
gatcgatcga tccatatgcg agccggccaa cagcttgc                             38


<210>  14
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  14
gatcgatcga tccatatggg cgccgagccg aggccgc                              37


<210>  15
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  15
gatcgatcgt cgacttagac caggaagcct cggatgg                              37


<210>  16
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  16
gagcggccgc ttagaccagg aagcctcgga tgg                                  33


<210>  17
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  17
taatattaat aaaaaatgcg agccggccaa cagcttgc                             38


<210>  18
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  18
taatattaat aaaaaatggg cgccgagccg ccgaggccgc ttccgc                    46


<210>  19
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
gccgccacca tgcgagccgg ccaacag                                         27


<210>  20
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  20
ttagaccagg aagcctcgg                                                  19


<210>  21
<211>  1042
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Pro Gly Ile Val Val Phe Arg Arg Arg Trp Ser Val Gly Ser Asp 
1               5                   10                  15      


Asp Leu Val Leu Pro Ala Ile Phe Leu Phe Leu Leu His Thr Thr Trp 
            20                  25                  30          


Phe Val Ile Leu Ser Val Val Leu Phe Gly Leu Val Tyr Asn Pro His 
        35                  40                  45              


Glu Ala Cys Ser Leu Asn Leu Val Asp His Gly Arg Gly Tyr Leu Gly 
    50                  55                  60                  


Ile Leu Leu Ser Cys Met Ile Ala Glu Met Ala Ile Ile Trp Leu Ser 
65                  70                  75                  80  


Met Arg Gly Gly Ile Leu Tyr Thr Glu Pro Arg Asp Ser Met Gln Tyr 
                85                  90                  95      


Val Leu Tyr Val Arg Leu Ala Ile Leu Val Ile Glu Phe Ile Tyr Ala 
            100                 105                 110         


Ile Val Gly Ile Val Trp Leu Thr Gln Tyr Tyr Thr Ser Cys Asn Asp 
        115                 120                 125             


Leu Thr Ala Lys Asn Val Thr Leu Gly Met Val Val Cys Asn Trp Val 
    130                 135                 140                 


Val Ile Leu Ser Val Cys Ile Thr Val Leu Cys Val Phe Asp Pro Thr 
145                 150                 155                 160 


Gly Arg Thr Phe Val Lys Leu Arg Ala Thr Lys Arg Arg Gln Arg Asn 
                165                 170                 175     


Leu Arg Thr Tyr Asn Leu Arg His Arg Leu Glu Glu Gly Gln Ala Thr 
            180                 185                 190         


Ser Trp Ser Arg Arg Leu Lys Val Phe Leu Cys Cys Thr Arg Thr Lys 
        195                 200                 205             


Asp Ser Gln Ser Asp Ala Tyr Ser Glu Ile Ala Tyr Leu Phe Ala Glu 
    210                 215                 220                 


Phe Phe Arg Asp Leu Asp Ile Val Pro Ser Asp Ile Ile Ala Gly Leu 
225                 230                 235                 240 


Val Leu Leu Arg Gln Arg Gln Arg Ala Lys Arg Asn Ala Val Leu Asp 
                245                 250                 255     


Glu Ala Asn Asn Asp Ile Leu Ala Phe Leu Ser Gly Met Pro Val Thr 
            260                 265                 270         


Arg Asn Thr Lys Tyr Leu Asp Leu Lys Asn Ser Gln Glu Met Leu Arg 
        275                 280                 285             


Tyr Lys Glu Val Cys Tyr Tyr Met Leu Phe Ala Leu Ala Ala Tyr Gly 
    290                 295                 300                 


Trp Pro Met Tyr Leu Met Arg Lys Pro Ala Cys Gly Leu Cys Gln Leu 
305                 310                 315                 320 


Ala Arg Ser Cys Ser Cys Cys Leu Cys Pro Ala Arg Pro Arg Phe Ala 
                325                 330                 335     


Pro Gly Val Thr Ile Glu Glu Asp Asn Cys Cys Gly Cys Asn Ala Ile 
            340                 345                 350         


Ala Ile Arg Arg His Phe Leu Asp Glu Asn Met Thr Ala Val Asp Ile 
        355                 360                 365             


Val Tyr Thr Ser Cys His Asp Ala Val Tyr Glu Thr Pro Phe Tyr Val 
    370                 375                 380                 


Ala Val Asp His Asp Lys Lys Lys Val Val Ile Ser Ile Arg Gly Thr 
385                 390                 395                 400 


Leu Ser Pro Lys Asp Ala Leu Thr Asp Leu Thr Gly Asp Ala Glu Arg 
                405                 410                 415     


Leu Pro Val Glu Gly His His Gly Thr Trp Leu Gly His Lys Gly Met 
            420                 425                 430         


Val Leu Ser Ala Glu Tyr Ile Lys Lys Lys Leu Glu Gln Glu Met Val 
        435                 440                 445             


Leu Ser Gln Ala Phe Gly Arg Asp Leu Gly Arg Gly Thr Lys His Tyr 
    450                 455                 460                 


Gly Leu Ile Val Val Gly His Ser Leu Gly Ala Gly Thr Ala Ala Ile 
465                 470                 475                 480 


Leu Ser Phe Leu Leu Arg Pro Gln Tyr Pro Thr Leu Lys Cys Phe Ala 
                485                 490                 495     


Tyr Ser Pro Pro Gly Gly Leu Leu Ser Glu Asp Ala Met Glu Tyr Ser 
            500                 505                 510         


Lys Glu Phe Val Thr Ala Val Val Leu Gly Lys Asp Leu Val Pro Arg 
        515                 520                 525             


Ile Gly Leu Ser Gln Leu Glu Gly Phe Arg Arg Gln Leu Leu Asp Val 
    530                 535                 540                 


Leu Gln Arg Ser Thr Lys Pro Lys Trp Arg Ile Ile Val Gly Ala Thr 
545                 550                 555                 560 


Lys Cys Ile Pro Lys Ser Glu Leu Pro Glu Glu Val Glu Val Thr Thr 
                565                 570                 575     


Leu Ala Ser Thr Arg Leu Trp Thr His Pro Ser Asp Leu Thr Ile Ala 
            580                 585                 590         


Leu Ser Ala Ser Thr Pro Leu Tyr Pro Pro Gly Arg Ile Ile His Val 
        595                 600                 605             


Val His Asn His Pro Ala Glu Gln Cys Cys Cys Cys Glu Gln Glu Glu 
    610                 615                 620                 


Pro Thr Tyr Phe Ala Ile Trp Gly Asp Asn Lys Ala Phe Asn Glu Val 
625                 630                 635                 640 


Ile Ile Ser Pro Ala Met Leu His Glu His Leu Pro Tyr Val Val Met 
                645                 650                 655     


Glu Gly Leu Asn Lys Val Leu Glu Asn Tyr Asn Lys Gly Lys Thr Ala 
            660                 665                 670         


Leu Leu Ser Ala Ala Lys Val Met Val Ser Pro Thr Glu Val Asp Leu 
        675                 680                 685             


Thr Pro Glu Leu Ile Phe Gln Gln Gln Pro Leu Pro Thr Gly Pro Pro 
    690                 695                 700                 


Met Pro Thr Gly Leu Ala Leu Glu Leu Pro Thr Ala Asp His Arg Asn 
705                 710                 715                 720 


Ser Ser Val Arg Ser Lys Ser Gln Ser Glu Met Ser Leu Glu Gly Phe 
                725                 730                 735     


Ser Glu Gly Arg Leu Leu Ser Pro Val Val Ala Ala Ala Ala Arg Gln 
            740                 745                 750         


Asp Pro Val Glu Leu Leu Leu Leu Ser Thr Gln Glu Arg Leu Ala Ala 
        755                 760                 765             


Glu Leu Gln Ala Arg Arg Ala Pro Leu Ala Thr Met Glu Ser Leu Ser 
    770                 775                 780                 


Asp Thr Glu Ser Leu Tyr Ser Phe Asp Ser Arg Arg Ser Ser Gly Phe 
785                 790                 795                 800 


Arg Ser Ile Arg Gly Ser Pro Ser Leu His Ala Val Leu Glu Arg Asp 
                805                 810                 815     


Glu Gly His Leu Phe Tyr Ile Asp Pro Ala Ile Pro Glu Glu Asn Pro 
            820                 825                 830         


Ser Leu Ser Ser Arg Thr Glu Leu Leu Ala Ala Asp Ser Leu Ser Lys 
        835                 840                 845             


His Ser Gln Asp Thr Gln Pro Leu Glu Ala Ala Leu Gly Ser Gly Gly 
    850                 855                 860                 


Val Thr Pro Glu Arg Pro Pro Ser Ala Ala Ala Asn Asp Glu Glu Glu 
865                 870                 875                 880 


Glu Val Gly Gly Gly Gly Gly Gly Pro Ala Ser Arg Gly Glu Leu Ala 
                885                 890                 895     


Leu His Asn Gly Arg Leu Gly Asp Ser Pro Ser Pro Gln Val Leu Glu 
            900                 905                 910         


Phe Ala Glu Phe Ile Asp Ser Leu Phe Asn Leu Asp Ser Lys Ser Ser 
        915                 920                 925             


Ser Phe Gln Asp Leu Tyr Cys Met Val Val Pro Glu Ser Pro Thr Ser 
    930                 935                 940                 


Asp Tyr Ala Glu Gly Pro Lys Ser Pro Ser Gln Gln Glu Ile Leu Leu 
945                 950                 955                 960 


Arg Ala Gln Phe Glu Pro Asn Leu Val Pro Lys Pro Pro Arg Leu Phe 
                965                 970                 975     


Ala Gly Ser Ala Asp Pro Ser Ser Gly Ile Ser Leu Ser Pro Ser Phe 
            980                 985                 990         


Pro Leu Ser Ser Ser Gly Glu Leu  Met Asp Leu Thr Pro  Thr Gly Leu 
        995                 1000                 1005             


Ser Ser  Gln Glu Cys Leu Ala  Ala Asp Lys Ile Arg  Thr Ser Thr 
    1010                 1015                 1020             


Pro Thr  Gly His Gly Ala Ser  Pro Ala Lys Gln Asp  Glu Leu Val 
    1025                 1030                 1035             


Ile Ser  Ala Arg 
    1040         


<210>  22
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Pro Gly Met Val Leu Phe Gly Arg Arg Trp Ala Ile Ala Ser Asp 
1               5                   10                  15      


Asp Leu Val Phe Pro Gly Phe Phe Glu Leu Val Val Arg Val Leu Trp 
            20                  25                  30          


Trp Ile Gly Ile Leu Thr Leu Tyr Leu Met His Arg Gly Lys Leu Asp 
        35                  40                  45              


Cys Ala Gly Gly Ala Leu Leu Ser Ser Tyr Leu Ile Val Leu Met Ile 
    50                  55                  60                  


Leu Leu Ala Val Val Ile Cys Thr Val Ser Ala Ile Met Cys Val Ser 
65                  70                  75                  80  


Met Arg Gly Thr Ile Cys Asn Pro Gly Pro Arg Lys Ser Met Ser Lys 
                85                  90                  95      


Leu Leu Tyr Ile Arg Leu Ala Leu Phe Phe Pro Glu Met Val Trp Ala 
            100                 105                 110         


Ser Leu Gly Ala Ala Trp Val Ala Asp Gly Val Gln Cys Asp Arg Thr 
        115                 120                 125             


Val Val Asn Gly Ile Ile Ala Thr Val Val Val Ser Trp Ile Ile Ile 
    130                 135                 140                 


Ala Ala Thr Val Val Ser Ile Ile Ile Val Phe Asp Pro Leu Gly Gly 
145                 150                 155                 160 


Lys Met Ala Pro Tyr Ser Ser Ala Gly Pro Ser His Leu Asp Ser His 
                165                 170                 175     


Asp Ser Ser Gln Leu Leu Asn Gly Leu Lys Thr Ala Ala Thr Ser Val 
            180                 185                 190         


Trp Glu Thr Arg Ile Lys Leu Leu Cys Cys Cys Ile Gly Lys Asp Asp 
        195                 200                 205             


His Thr Arg Val Ala Phe Ser Ser Thr Ala Glu Leu Phe Ser Thr Tyr 
    210                 215                 220                 


Phe Ser Asp Thr Asp Leu Val Pro Ser Asp Ile Ala Ala Gly Leu Ala 
225                 230                 235                 240 


Leu Leu His Gln Gln Gln Asp Asn Ile Arg Asn Asn Gln Glu Pro Ala 
                245                 250                 255     


Gln Val Val Cys His Ala Pro Gly Ser Ser Gln Glu Ala Asp Leu Asp 
            260                 265                 270         


Ala Glu Leu Glu Asn Cys His His Tyr Met Gln Phe Ala Ala Ala Ala 
        275                 280                 285             


Tyr Gly Trp Pro Leu Tyr Ile Tyr Arg Asn Pro Leu Thr Gly Leu Cys 
    290                 295                 300                 


Arg Ile Gly Gly Asp Cys Cys Arg Ser Arg Thr Thr Asp Tyr Asp Leu 
305                 310                 315                 320 


Val Gly Gly Asp Gln Leu Asn Cys His Phe Gly Ser Ile Leu His Thr 
                325                 330                 335     


Thr Gly Leu Gln Tyr Arg Asp Phe Ile His Val Ser Phe His Asp Lys 
            340                 345                 350         


Val Tyr Glu Leu Pro Phe Leu Val Ala Leu Asp His Arg Lys Glu Ser 
        355                 360                 365             


Val Val Val Ala Val Arg Gly Thr Met Ser Leu Gln Asp Val Leu Thr 
    370                 375                 380                 


Asp Leu Ser Ala Glu Ser Glu Val Leu Asp Val Glu Cys Glu Val Gln 
385                 390                 395                 400 


Asp Arg Leu Ala His Lys Gly Ile Ser Gln Ala Ala Arg Tyr Val Tyr 
                405                 410                 415     


Gln Arg Leu Ile Asn Asp Gly Ile Leu Ser Gln Ala Phe Ser Ile Ala 
            420                 425                 430         


Pro Glu Tyr Arg Leu Val Ile Val Gly His Ser Leu Gly Gly Gly Ala 
        435                 440                 445             


Ala Ala Leu Leu Ala Thr Met Leu Arg Ala Ala Tyr Pro Gln Val Arg 
    450                 455                 460                 


Cys Tyr Ala Phe Ser Pro Pro Arg Gly Leu Trp Ser Lys Ala Leu Gln 
465                 470                 475                 480 


Glu Tyr Ser Gln Ser Phe Ile Val Ser Leu Val Leu Gly Lys Asp Val 
                485                 490                 495     


Ile Pro Arg Leu Ser Val Thr Asn Leu Glu Asp Leu Lys Arg Arg Ile 
            500                 505                 510         


Leu Arg Val Val Ala His Cys Asn Lys Pro Lys Tyr Lys Ile Leu Leu 
        515                 520                 525             


His Gly Leu Trp Tyr Glu Leu Phe Gly Gly Asn Pro Asn Asn Leu Pro 
    530                 535                 540                 


Thr Glu Leu Asp Gly Gly Asp Gln Glu Val Leu Thr Gln Pro Leu Leu 
545                 550                 555                 560 


Gly Glu Gln Ser Leu Leu Thr Arg Trp Ser Pro Ala Tyr Ser Phe Ser 
                565                 570                 575     


Ser Asp Ser Pro Leu Asp Ser Ser Pro Lys Tyr Pro Pro Leu Tyr Pro 
            580                 585                 590         


Pro Gly Arg Ile Ile His Leu Gln Glu Glu Gly Ala Ser Gly Arg Phe 
        595                 600                 605             


Gly Cys Cys Ser Ala Ala His Tyr Ser Ala Lys Trp Ser His Glu Ala 
    610                 615                 620                 


Glu Phe Ser Lys Ile Leu Ile Gly Pro Lys Met Leu Thr Asp His Met 
625                 630                 635                 640 


Pro Asp Ile Leu Met Arg Ala Leu Asp Ser Val Val Ser Asp Arg Ala 
                645                 650                 655     


Ala Cys Val Ser Cys Pro Ala Gln Gly Val Ser Ser Val Asp Val Ala 
            660                 665                 670         


<210>  23
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  23

Val Pro Ala Pro Ser Ser Ser Ser Gly Gly Arg Gly Gly Ala Glu Pro 
1               5                   10                  15      


Arg 
    


<210>  24
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  24

Val Pro Val Ala Pro Ser Ser Ser Ser Gly Gly Arg 
1               5                   10          


<210>  25
<211>  11
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  25

Ser Ser Gly Gly Arg Gly Gly Ala Glu Pro Arg 
1               5                   10      


<210>  26
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  26

Gly Gly Ala Glu Pro Arg Pro Leu Pro Leu Ser Tyr Arg 
1               5                   10              


<210>  27
<211>  21
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  27

Leu Leu Asp Gly Glu Ala Ala Leu Pro Ala Val Val Phe Leu His Gly 
1               5                   10                  15      


Leu Phe Gly Ser Lys 
            20      


<210>  28
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  28

Thr Asn Phe Asn Ser Ile Ala Lys 
1               5               


<210>  29
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  29

Thr Asn Phe Asn Ser Ile Ala Lys Ile Leu Ala Gln Gln Thr Gly Arg 
1               5                   10                  15      


<210>  30
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  30

Ile Leu Ala Gln Gln Thr Gly Arg 
1               5               


<210>  31
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  31

Ile Leu Ala Gln Gln Thr Gly Arg Arg 
1               5                   


<210>  32
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  32

Arg Val Leu Thr Val Asp Ala Arg 
1               5               


<210>  33
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  33

Val Leu Thr Val Asp Ala Arg 
1               5           


<210>  34
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  34

Thr Ala Met Leu Leu Ala Leu Gln Arg Pro Glu Leu Val Glu Arg 
1               5                   10                  15  


<210>  35
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  35

Leu Ile Ala Val Asp Ile Ser Pro Val Glu Ser Thr Gly Val Ser His 
1               5                   10                  15      


Phe Ala Thr Tyr Val Ala Ala Met Arg 
            20                  25  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  36

Ala Ile Asn Ile Ala Asp Glu Leu Pro Arg 
1               5                   10  


<210>  37
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  37

Ala Ile Asn Ile Ala Asp Glu Leu Pro Arg Ser Arg 
1               5                   10          


<210>  38
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  38

Ser Arg Ala Arg Lys 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  39

Lys Leu Ala Asp Glu Gln Leu Ser Ser Val Ile Gln Asp Met Ala Val 
1               5                   10                  15      


Arg 
    


<210>  40
<211>  16
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  40

Leu Ala Asp Glu Gln Leu Ser Ser Val Ile Gln Asp Met Ala Val Arg 
1               5                   10                  15      


<210>  41
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  41

Gln His Leu Leu Thr Asn Leu Val Glu Val Asp Gly Arg 
1               5                   10              


<210>  42
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  42

Phe Val Trp Arg 
1               


<210>  43
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  43

Val Asn Leu Asp Ala Leu Thr Gln His Leu Asp Lys 
1               5                   10          


<210>  44
<211>  19
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  44

Val Asn Leu Asp Ala Leu Thr Gln His Leu Asp Lys Ile Leu Ala Phe 
1               5                   10                  15      


Pro Gln Arg 
            


<210>  45
<211>  7
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  45

Ile Leu Ala Phe Pro Gln Arg 
1               5           


<210>  46
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  46

Leu Phe Pro Arg 
1               


<210>  47
<211>  26
<212>  PRT
<213>  Artificial

<220>
<223>  peptide

<400>  47

Ala Gln Met Gln Thr Val Pro Asn Ala Gly His Trp Ile His Ala Asp 
1               5                   10                  15      


Arg Pro Gln Asp Phe Ile Ala Ala Ile Arg 
            20                  25      


<210>  48
<211>  421
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (125)..(129)
<223>  GXSXG lipase consensus

<400>  48

Met Ala Ala Gly Phe Gly Arg Cys Cys Arg Val Leu Arg Ser Ile Ser 
1               5                   10                  15      


Arg Phe His Trp Arg Ser Gln His Thr Lys Ala Asn Arg Gln Arg Glu 
            20                  25                  30          


Pro Gly Leu Gly Phe Ser Phe Glu Phe Thr Glu Gln Gln Lys Glu Phe 
        35                  40                  45              


Gln Ala Thr Ala Arg Lys Phe Ala Arg Glu Glu Ile Ile Pro Val Ala 
    50                  55                  60                  


Ala Glu Tyr Asp Lys Thr Gly Glu Tyr Pro Val Pro Leu Ile Arg Arg 
65                  70                  75                  80  


Ala Trp Glu Leu Gly Leu Met Asn Thr His Ile Pro Glu Asn Cys Gly 
                85                  90                  95      


Gly Leu Gly Leu Gly Thr Phe Asp Ala Cys Leu Ile Ser Glu Glu Leu 
            100                 105                 110         


Ala Tyr Gly Cys Thr Gly Val Gln Thr Ala Ile Glu Gly Asn Ser Leu 
        115                 120                 125             


Gly Gln Met Pro Ile Ile Ile Ala Gly Asn Asp Gln Gln Lys Lys Lys 
    130                 135                 140                 


Tyr Leu Gly Arg Met Thr Glu Glu Pro Leu Met Cys Ala Tyr Cys Val 
145                 150                 155                 160 


Thr Glu Pro Gly Ala Gly Ser Asp Val Ala Gly Ile Lys Thr Lys Ala 
                165                 170                 175     


Glu Lys Lys Gly Asp Glu Tyr Ile Ile Asn Gly Gln Lys Met Trp Ile 
            180                 185                 190         


Thr Asn Gly Gly Lys Ala Asn Trp Tyr Phe Leu Leu Ala Arg Ser Asp 
        195                 200                 205             


Pro Asp Pro Lys Ala Pro Ala Asn Lys Ala Phe Thr Gly Phe Ile Val 
    210                 215                 220                 


Glu Ala Asp Thr Pro Gly Ile Gln Ile Gly Arg Lys Glu Leu Asn Met 
225                 230                 235                 240 


Gly Gln Arg Cys Ser Asp Thr Arg Gly Ile Val Phe Glu Asp Val Lys 
                245                 250                 255     


Val Pro Lys Glu Asn Val Leu Ile Gly Asp Gly Ala Gly Phe Lys Val 
            260                 265                 270         


Ala Met Gly Ala Phe Asp Lys Thr Arg Pro Val Val Ala Ala Gly Ala 
        275                 280                 285             


Val Gly Leu Ala Gln Arg Ala Leu Asp Glu Ala Thr Lys Tyr Ala Leu 
    290                 295                 300                 


Glu Arg Lys Thr Phe Gly Lys Leu Leu Val Glu His Gln Ala Ile Ser 
305                 310                 315                 320 


Phe Met Leu Ala Glu Met Ala Met Lys Val Glu Leu Ala Arg Met Ser 
                325                 330                 335     


Tyr Gln Arg Ala Ala Trp Glu Val Asp Ser Gly Arg Arg Asn Thr Tyr 
            340                 345                 350         


Tyr Ala Ser Ile Ala Lys Ala Phe Ala Gly Asp Ile Ala Asn Gln Leu 
        355                 360                 365             


Ala Thr Asp Ala Val Gln Ile Leu Gly Gly Asn Gly Phe Asn Thr Glu 
    370                 375                 380                 


Tyr Pro Val Glu Lys Leu Met Arg Asp Ala Lys Ile Tyr Gln Ile Tyr 
385                 390                 395                 400 


Glu Gly Thr Ser Gln Ile Gln Arg Leu Ile Val Ala Arg Glu His Ile 
                405                 410                 415     


Asp Lys Tyr Lys Asn 
            420     


<210>  49
<211>  291
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (137)..(141)
<223>  GXSXG lipase consensus

<400>  49

Met Ala Thr Ala Thr Val Arg Pro Ala Ala Gln Arg Leu Arg Leu Leu 
1               5                   10                  15      


Leu Ser Pro Leu Lys Ser Arg Ile Cys Val Pro Gln Ala Glu Pro Val 
            20                  25                  30          


Ala Thr Phe Gly Thr Ala Val Thr Ser Ala Lys Val Ala Val Asn Gly 
        35                  40                  45              


Val His Leu His Tyr Gln Arg Val Gly Glu Gly Glu His Ala Ile Leu 
    50                  55                  60                  


Leu Leu Pro Gly Met Leu Gly Ser Gly Lys Thr Asp Phe Ala Pro Gln 
65                  70                  75                  80  


Leu Gln Ser Leu Asn Lys Lys Arg Phe Thr Leu Val Ala Trp Asp Pro 
                85                  90                  95      


Arg Gly Tyr Gly Tyr Ser Arg Pro Pro Asp Arg Asp Phe Pro Arg Asp 
            100                 105                 110         


Phe Phe Glu Arg Asp Ala Lys Asp Ala Val Asp Leu Met Lys Ala Leu 
        115                 120                 125             


Gln Phe Lys Gln Val Ser Leu Leu Gly Trp Ser Asp Gly Gly Ile Thr 
    130                 135                 140                 


Ala Leu Ile Ala Ala Ala Lys Tyr Pro Ser Tyr Ile Arg Lys Met Val 
145                 150                 155                 160 


Ile Trp Gly Ala Asn Ala Tyr Val Thr Glu Glu Asp Ser Arg Ile Tyr 
                165                 170                 175     


Gln Gly Ile Arg Asp Val Ser Lys Trp Ser Glu Lys Ala Arg Lys Pro 
            180                 185                 190         


Leu Glu Ala Leu Tyr Gly Tyr Asp Tyr Leu Ala Lys Thr Cys Glu Asp 
        195                 200                 205             


Trp Val Asp Gly Ile Ser Gln Phe Lys Gln Leu Pro Glu Gly Asn Ile 
    210                 215                 220                 


Cys Arg His Leu Leu Pro Leu Val Gln Cys Pro Thr Leu Ile Val His 
225                 230                 235                 240 


Gly Glu Lys Asp Pro Leu Val Pro Arg Phe His Ala Asp Phe Leu Leu 
                245                 250                 255     


Gln His Val Lys Gly Ser Arg Leu His Leu Met Pro Glu Gly Lys His 
            260                 265                 270         


Asn Leu His Leu Arg Phe Ala Asp Glu Phe Asn Arg Leu Val Glu Asp 
        275                 280                 285             


Phe Leu Gln 
    290     


<210>  50
<211>  253
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (28)..(32)
<223>  GXSXG lipase consensus

<400>  50

Met Ala Leu Ser Met Pro Leu Asn Gly Leu Lys Glu Glu Asp Lys Glu 
1               5                   10                  15      


Pro Leu Ile Glu Leu Phe Val Lys Ala Gly Ser Asp Gly Glu Ser Ile 
            20                  25                  30          


Gly Asn Cys Pro Phe Ser Gln Arg Leu Phe Met Ile Leu Trp Leu Lys 
        35                  40                  45              


Gly Val Val Phe Ser Val Thr Thr Val Asp Leu Lys Arg Lys Pro Ala 
    50                  55                  60                  


Asp Leu Gln Asn Leu Ala Pro Gly Thr His Pro Pro Phe Ile Thr Phe 
65                  70                  75                  80  


Asn Ser Glu Val Lys Thr Asp Val Asn Lys Ile Glu Glu Phe Leu Glu 
                85                  90                  95      


Glu Val Leu Cys Pro Pro Lys Tyr Leu Lys Leu Ser Pro Lys His Pro 
            100                 105                 110         


Glu Ser Asn Thr Ala Gly Met Asp Ile Phe Ala Lys Phe Ser Ala Tyr 
        115                 120                 125             


Ile Lys Asn Ser Arg Pro Glu Ala Asn Glu Ala Leu Glu Arg Gly Leu 
    130                 135                 140                 


Leu Lys Thr Leu Gln Lys Leu Asp Glu Tyr Leu Asn Ser Pro Leu Pro 
145                 150                 155                 160 


Asp Glu Ile Asp Glu Asn Ser Met Glu Asp Ile Lys Phe Ser Thr Arg 
                165                 170                 175     


Arg Phe Leu Asp Gly Asp Glu Met Thr Leu Ala Asp Cys Asn Leu Leu 
            180                 185                 190         


Pro Lys Leu His Ile Val Lys Val Val Ala Lys Lys Tyr Arg Asn Phe 
        195                 200                 205             


Asp Ile Pro Lys Gly Met Thr Gly Ile Trp Arg Tyr Leu Thr Asn Ala 
    210                 215                 220                 


Tyr Ser Arg Asp Glu Phe Thr Asn Thr Cys Pro Ser Asp Lys Glu Val 
225                 230                 235                 240 


Glu Ile Ala Tyr Ser Asp Val Ala Lys Arg Leu Thr Lys 
                245                 250             


<210>  51
<211>  575
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (417)..(421)
<223>  GXSXG lipase consensus

<400>  51

Met Ser Thr Ser Ser Leu Arg Arg Gln Met Lys Asn Ile Val His Asn 
1               5                   10                  15      


Tyr Ser Glu Ala Glu Ile Lys Val Arg Glu Ala Thr Ser Asn Asp Pro 
            20                  25                  30          


Trp Gly Pro Ser Ser Ser Leu Met Ser Glu Ile Ala Asp Leu Thr Tyr 
        35                  40                  45              


Asn Val Val Ala Phe Ser Glu Ile Met Ser Met Ile Trp Lys Arg Leu 
    50                  55                  60                  


Asn Asp His Gly Lys Asn Trp Arg His Val Tyr Lys Ala Met Thr Leu 
65                  70                  75                  80  


Met Glu Tyr Leu Ile Lys Thr Gly Ser Glu Arg Val Ser Gln Gln Cys 
                85                  90                  95      


Lys Glu Asn Met Tyr Ala Val Gln Thr Leu Lys Asp Phe Gln Tyr Val 
            100                 105                 110         


Asp Arg Asp Gly Lys Asp Gln Gly Val Asn Val Arg Glu Lys Ala Lys 
        115                 120                 125             


Gln Leu Val Ala Leu Leu Arg Asp Glu Asp Arg Leu Arg Glu Glu Arg 
    130                 135                 140                 


Ala His Ala Leu Lys Thr Lys Glu Lys Leu Ala Gln Thr Ala Thr Ala 
145                 150                 155                 160 


Ser Ser Ala Ala Val Gly Ser Gly Pro Pro Pro Glu Ala Glu Gln Ala 
                165                 170                 175     


Trp Pro Gln Ser Ser Gly Glu Glu Glu Leu Gln Leu Gln Leu Ala Leu 
            180                 185                 190         


Ala Met Ser Lys Glu Glu Ala Asp Gln Pro Pro Ser Cys Gly Pro Glu 
        195                 200                 205             


Asp Asp Val Gln Leu Gln Leu Ala Leu Ser Leu Ser Arg Glu Glu His 
    210                 215                 220                 


Asp Lys Glu Glu Arg Ile Arg Arg Gly Asp Asp Leu Arg Leu Gln Met 
225                 230                 235                 240 


Ala Ile Glu Glu Ser Lys Arg Glu Thr Gly Gly Lys Glu Glu Ser Ser 
                245                 250                 255     


Leu Met Asp Leu Ala Asp Val Phe Thr Thr Pro Ala Pro Pro Gln Ala 
            260                 265                 270         


Ser Asp Pro Trp Gly Gly Pro Ala Ser Val Pro Thr Ala Val Pro Val 
        275                 280                 285             


Ala Ala Ala Ala Ser Asp Pro Trp Gly Ala Pro Ala Val Pro Pro Ala 
    290                 295                 300                 


Ala Asp Pro Trp Gly Gly Ala Ala Pro Thr Pro Ala Ser Gly Asp Pro 
305                 310                 315                 320 


Trp Arg Pro Ala Ala Pro Thr Gly Pro Ser Val Asp Pro Trp Gly Gly 
                325                 330                 335     


Thr Pro Ala Pro Ala Ala Gly Glu Gly Pro Thr Ser Asp Pro Trp Gly 
            340                 345                 350         


Ser Ala Asp Gly Gly Ala Pro Val Ser Gly Pro Pro Ser Ser Asp Pro 
        355                 360                 365             


Trp Ala Pro Ala Pro Ala Phe Ser Asp Pro Trp Gly Gly Ser Pro Ala 
    370                 375                 380                 


Lys Pro Ser Ser Asn Gly Thr Ala Val Gly Gly Phe Asp Thr Glu Pro 
385                 390                 395                 400 


Asp Glu Phe Ser Asp Phe Asp Arg Leu Arg Thr Ala Leu Pro Thr Ser 
                405                 410                 415     


Gly Ser Ser Thr Gly Glu Leu Glu Leu Leu Ala Gly Glu Val Pro Ala 
            420                 425                 430         


Arg Ser Pro Gly Ala Phe Asp Met Ser Gly Val Gly Gly Ser Leu Ala 
        435                 440                 445             


Glu Ser Val Gly Ser Pro Pro Pro Ala Ala Thr Pro Thr Pro Thr Pro 
    450                 455                 460                 


Pro Thr Arg Lys Thr Pro Glu Ser Phe Leu Gly Pro Asn Ala Ala Leu 
465                 470                 475                 480 


Val Asp Leu Asp Ser Leu Val Ser Arg Pro Gly Pro Thr Pro Pro Gly 
                485                 490                 495     


Ala Lys Ala Ser Asn Pro Phe Leu Pro Ser Gly Ala Pro Ala Thr Gly 
            500                 505                 510         


Pro Ser Val Thr Asn Pro Phe Gln Pro Ala Pro Pro Ala Thr Leu Thr 
        515                 520                 525             


Leu Asn Gln Leu Arg Leu Ser Pro Val Pro Pro Val Pro Gly Ala Pro 
    530                 535                 540                 


Pro Thr Tyr Ile Ser Pro Leu Gly Gly Gly Pro Gly Leu Pro Pro Met 
545                 550                 555                 560 


Met Pro Pro Gly Pro Pro Ala Pro Asn Thr Asn Pro Phe Leu Leu 
                565                 570                 575 


<210>  52
<211>  338
<212>  PRT
<213>  Sus scrofa


<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  MISC_FEATURE
<222>  (31)..(35)
<223>  GXSXG lipase consensus

<400>  52

Met Leu Ser Ala Leu Ala Arg Pro Ala Gly Ala Ala Leu Arg Arg Ser 
1               5                   10                  15      


Phe Ser Thr Ser Xaa Gln Asn Asn Ala Lys Val Ala Val Leu Gly Ala 
            20                  25                  30          


Ser Gly Gly Ile Gly Gln Pro Leu Ser Leu Leu Leu Lys Asn Ser Pro 
        35                  40                  45              


Leu Val Ser Arg Leu Thr Leu Tyr Asp Ile Ala His Thr Pro Gly Val 
    50                  55                  60                  


Ala Ala Asp Leu Ser His Ile Glu Thr Arg Ala Thr Val Lys Gly Tyr 
65                  70                  75                  80  


Leu Gly Pro Glu Gln Leu Pro Asp Cys Leu Lys Gly Cys Asp Val Val 
                85                  90                  95      


Val Ile Pro Ala Gly Val Pro Arg Lys Pro Gly Met Thr Arg Asp Asp 
            100                 105                 110         


Leu Phe Asn Thr Asn Ala Thr Ile Val Ala Thr Leu Thr Ala Ala Cys 
        115                 120                 125             


Ala Gln His Cys Pro Asp Ala Met Ile Cys Ile Ile Ser Asn Pro Val 
    130                 135                 140                 


Asn Ser Thr Ile Pro Ile Thr Ala Glu Val Phe Lys Lys His Gly Val 
145                 150                 155                 160 


Tyr Asn Pro Asn Lys Ile Phe Gly Val Thr Thr Leu Asp Ile Val Arg 
                165                 170                 175     


Ala Asn Ala Phe Val Ala Glu Leu Lys Gly Leu Asp Pro Ala Arg Val 
            180                 185                 190         


Ser Val Pro Val Ile Gly Gly His Ala Gly Lys Thr Ile Ile Pro Leu 
        195                 200                 205             


Ile Ser Gln Cys Thr Pro Lys Val Asp Phe Pro Gln Asp Gln Leu Ser 
    210                 215                 220                 


Thr Leu Thr Gly Arg Ile Gln Glu Ala Gly Thr Glu Val Val Lys Ala 
225                 230                 235                 240 


Lys Ala Gly Ala Gly Ser Ala Thr Leu Ser Met Ala Tyr Ala Gly Ala 
                245                 250                 255     


Arg Phe Val Phe Ser Leu Val Asp Ala Met Asn Gly Lys Glu Gly Val 
            260                 265                 270         


Val Glu Cys Ser Phe Val Lys Ser Gln Glu Thr Asp Cys Pro Tyr Phe 
        275                 280                 285             


Ser Thr Pro Leu Leu Leu Gly Lys Lys Gly Ile Glu Lys Asn Leu Gly 
    290                 295                 300                 


Ile Gly Lys Ile Ser Pro Phe Glu Glu Lys Met Ile Ala Glu Ala Ile 
305                 310                 315                 320 


Pro Glu Leu Lys Ala Ser Ile Lys Lys Gly Glu Glu Phe Val Lys Asn 
                325                 330                 335     


Met Lys 
        


<210>  53
<211>  434
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  MISC_FEATURE
<222>  (38)..(42)
<223>  GXSXG lipase consensus

<400>  53

Met Ser Ile Leu Lys Ile His Ala Arg Glu Ile Phe Asp Ser Arg Gly 
1               5                   10                  15      


Asn Pro Thr Val Glu Val Asp Leu Tyr Thr Ala Lys Gly Leu Phe Arg 
            20                  25                  30          


Ala Ala Val Pro Ser Gly Ala Ser Thr Gly Ile Tyr Glu Ala Leu Glu 
        35                  40                  45              


Leu Arg Asp Asn Asp Lys Thr Arg Phe Met Gly Lys Gly Val Ser Lys 
    50                  55                  60                  


Ala Val Glu His Ile Asn Lys Thr Ile Ala Pro Ala Leu Val Ser Lys 
65                  70                  75                  80  


Lys Leu Asn Val Val Glu Gln Glu Lys Ile Asp Gln Leu Met Ile Glu 
                85                  90                  95      


Met Asp Gly Thr Glu Asn Lys Ser Lys Phe Gly Ala Asn Ala Ile Leu 
            100                 105                 110         


Gly Val Ser Leu Ala Val Cys Lys Ala Gly Ala Val Glu Lys Gly Val 
        115                 120                 125             


Pro Leu Tyr Arg His Ile Ala Asp Leu Ala Gly Asn Pro Glu Val Ile 
    130                 135                 140                 


Leu Pro Val Pro Ala Phe Asn Val Ile Asn Gly Gly Ser His Ala Gly 
145                 150                 155                 160 


Asn Lys Leu Ala Met Gln Glu Phe Met Ile Leu Pro Val Gly Ala Ser 
                165                 170                 175     


Ser Phe Arg Glu Ala Met Arg Ile Gly Ala Glu Val Tyr His Asn Leu 
            180                 185                 190         


Lys Asn Val Ile Lys Glu Lys Tyr Gly Lys Asp Ala Thr Asn Val Gly 
        195                 200                 205             


Asp Glu Gly Gly Phe Ala Pro Asn Ile Leu Glu Asn Lys Glu Ala Leu 
    210                 215                 220                 


Glu Leu Leu Lys Ser Ala Ile Ala Lys Ala Gly Tyr Thr Asp Gln Val 
225                 230                 235                 240 


Val Ile Gly Met Asp Val Ala Ala Ser Glu Phe Tyr Arg Ala Gly Lys 
                245                 250                 255     


Tyr Asp Leu Asp Phe Lys Ser Pro Asp Asp Ala Ser Arg Tyr Ile Thr 
            260                 265                 270         


Pro Asp Gln Leu Ala Asp Leu Tyr Lys Ser Phe Ile Lys Asp Tyr Pro 
        275                 280                 285             


Val Val Ser Ile Glu Asp Pro Phe Asp Gln Asp Asp Trp Asp Ala Trp 
    290                 295                 300                 


Gln Lys Phe Thr Ala Thr Ala Gly Ile Gln Val Val Gly Asp Asp Leu 
305                 310                 315                 320 


Thr Val Thr Asn Pro Lys Arg Ile Ala Lys Ala Ala Gly Glu Lys Ser 
                325                 330                 335     


Cys Asn Cys Leu Leu Leu Lys Val Asn Gln Ile Gly Ser Val Thr Glu 
            340                 345                 350         


Ser Leu Gln Ala Cys Lys Leu Ala Gln Ser Asn Gly Trp Gly Val Met 
        355                 360                 365             


Val Ser His Arg Ser Gly Glu Thr Glu Asp Thr Phe Ile Ala Asp Leu 
    370                 375                 380                 


Val Val Gly Leu Cys Thr Gly Gln Ile Lys Thr Gly Ala Pro Cys Arg 
385                 390                 395                 400 


Ser Glu Arg Leu Ala Lys Tyr Asn Gln Ile Leu Arg Ile Glu Glu Glu 
                405                 410                 415     


Leu Gly Ser Lys Ala Lys Phe Ala Gly Arg Ser Phe Arg Asn Pro Leu 
            420                 425                 430         


Ala Lys 
        


<210>  54
<211>  961
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (99)..(103)
<223>  GXSXG lipase consensus

<400>  54

Met Ala Gly Gly Thr Gly Cys Val Arg Leu Trp Gly Ala Ala Arg Cys 
1               5                   10                  15      


Trp Thr Leu Arg Arg Pro Leu Leu Ala Ala Ala Gly Gly Arg Val Pro 
            20                  25                  30          


Thr Ala Ala Arg Ala Trp Leu Pro Arg Gly Arg Arg Ala Cys Asp Ala 
        35                  40                  45              


Ser Pro Pro Trp Ala Leu Trp Gly Gln Ser Pro Ala Ala Ala Gly His 
    50                  55                  60                  


Trp Arg Gly Leu Trp Glu Ala Asn Asn Arg Ser Gly Gly Gly Ala Phe 
65                  70                  75                  80  


Ser Gly Gly Glu Asp Ala Ser Glu Gly Gly Ala Glu Asp Gly Ala Ser 
                85                  90                  95      


Gly Val Gly Gly Ser Ala Gly Gly Gly Glu Gly Pro Val Ile Thr Ala 
            100                 105                 110         


Leu Thr Pro Met Met Ile Pro Asp Val Phe Pro His Leu Pro Leu Ile 
        115                 120                 125             


Ala Val Thr Arg Asn Pro Val Phe Pro Arg Phe Ile Lys Ile Val Glu 
    130                 135                 140                 


Val Lys Asn Lys Lys Leu Val Glu Leu Leu Arg Arg Lys Val His Leu 
145                 150                 155                 160 


Ala Gln Pro Tyr Ala Gly Val Phe Leu Lys Lys Asp Asp Asn Asn Glu 
                165                 170                 175     


Ser Asp Val Val Glu Asn Leu Asp Glu Ile Tyr His Thr Gly Thr Phe 
            180                 185                 190         


Val Gln Ile His Glu Met Gln Asp Leu Gly Asp Lys Leu Arg Met Ile 
        195                 200                 205             


Val Met Gly His Arg Arg Val His Ile Asn Arg Gln Leu Glu Val Glu 
    210                 215                 220                 


Pro Glu Glu Pro Glu Gly Glu Asn Lys Gln Lys Leu Arg Lys Lys Pro 
225                 230                 235                 240 


Lys Arg Gly Lys Lys Glu Ala Glu Glu Asp Gly Ala Thr Lys Arg Pro 
                245                 250                 255     


Leu Glu Val Val Val Gly Pro Gly Pro Ser Pro Ala Gly Glu Val Leu 
            260                 265                 270         


Met Val Glu Val Glu Asn Val Ala His Glu Asp Phe Gln Val Thr Glu 
        275                 280                 285             


Glu Val Lys Ala Leu Thr Ala Glu Ile Val Lys Thr Ile Arg Asp Ile 
    290                 295                 300                 


Ile Ala Leu Asn Pro Leu Tyr Arg Glu Ser Val Leu Gln Met Met Gln 
305                 310                 315                 320 


Ala Gly His Arg Val Val Asp Asn Pro Ile Tyr Leu Ser Asp Met Gly 
                325                 330                 335     


Ala Ala Leu Thr Gly Ala Glu Ser His Glu Leu Gln Glu Val Leu Glu 
            340                 345                 350         


Glu Thr Asn Ile Pro Lys Arg Leu Tyr Lys Ala Leu Ser Leu Leu Lys 
        355                 360                 365             


Lys Glu Phe Glu Leu Ser Lys Leu Gln Gln Arg Leu Gly Arg Glu Val 
    370                 375                 380                 


Glu Glu Lys Ile Lys Gln Thr His Arg Lys Tyr Leu Leu Gln Glu Gln 
385                 390                 395                 400 


Leu Lys Ile Ile Lys Lys Glu Leu Gly Leu Glu Lys Asp Asp Lys Asp 
                405                 410                 415     


Ala Ile Glu Glu Lys Phe Arg Glu Arg Leu Lys Glu Leu Val Val Pro 
            420                 425                 430         


Lys His Val Met Asp Val Val Asp Glu Glu Leu Ser Lys Leu Gly Leu 
        435                 440                 445             


Leu Asp Asn His Ser Ser Glu Phe Asn Val Thr Arg Asn Tyr Leu Asp 
    450                 455                 460                 


Trp Leu Thr Ser Ile Pro Trp Gly Lys His Ser Asp Glu Asn Leu Asp 
465                 470                 475                 480 


Leu Ala Arg Ala Gln Ala Val Leu Glu Glu Asp His Tyr Gly Met Glu 
                485                 490                 495     


Asp Val Lys Lys Arg Ile Leu Glu Phe Ile Ala Val Ser Gln Leu Arg 
            500                 505                 510         


Gly Ser Thr Gln Gly Lys Ile Leu Cys Phe Tyr Gly Pro Pro Gly Val 
        515                 520                 525             


Gly Lys Thr Ser Ile Ala Arg Ser Ile Ala Arg Ala Leu Asn Arg Glu 
    530                 535                 540                 


Tyr Phe Arg Phe Ser Val Gly Gly Met Thr Asp Val Ala Glu Ile Lys 
545                 550                 555                 560 


Gly His Arg Arg Thr Tyr Val Gly Ala Met Pro Gly Lys Ile Ile Gln 
                565                 570                 575     


Cys Leu Lys Lys Thr Lys Thr Glu Asn Pro Leu Val Leu Ile Asp Glu 
            580                 585                 590         


Val Asp Lys Ile Gly Arg Gly Tyr Gln Gly Asp Pro Ser Ser Ala Leu 
        595                 600                 605             


Leu Glu Leu Leu Asp Pro Glu Gln Asn Ala Asn Phe Leu Asp His Tyr 
    610                 615                 620                 


Leu Asp Val Pro Val Asp Leu Ser Lys Val Leu Phe Ile Cys Thr Ala 
625                 630                 635                 640 


Asn Ile Thr Glu Thr Ile Pro Glu Pro Leu Arg Asp Arg Met Glu Met 
                645                 650                 655     


Ile Asn Val Ser Gly Tyr Val Ala Gln Glu Lys Leu Ala Ile Ala Glu 
            660                 665                 670         


Arg Tyr Leu Val Pro Gln Ala Arg Ala Leu Cys Gly Leu Asp Glu Ser 
        675                 680                 685             


Lys Ala Lys Leu Ser Ser Asp Val Leu Thr Leu Leu Ile Lys Gln Tyr 
    690                 695                 700                 


Cys Arg Glu Ser Gly Val Arg Asn Leu Gln Lys Gln Val Glu Lys Val 
705                 710                 715                 720 


Leu Arg Lys Ser Ala Tyr Lys Ile Val Ser Gly Glu Ala Glu Phe Val 
                725                 730                 735     


Glu Val Thr Pro Glu Asn Leu Gln Asp Phe Val Gly Lys Pro Val Phe 
            740                 745                 750         


Thr Val Glu Arg Met Tyr Asp Val Thr Pro Pro Gly Val Val Met Gly 
        755                 760                 765             


Leu Ala Trp Thr Ala Met Gly Gly Ser Thr Leu Phe Val Glu Thr Ser 
    770                 775                 780                 


Leu Arg Arg Pro Arg Asp Arg Asp Ser Asp Lys Gly Asp Lys Asp Gly 
785                 790                 795                 800 


Ser Leu Glu Val Thr Gly Gln Leu Gly Glu Val Met Lys Glu Ser Ala 
                805                 810                 815     


Arg Ile Ala Tyr Thr Phe Ala Arg Ala Phe Leu Met Gln His Asp Ser 
            820                 825                 830         


Ala Asn Lys Phe Leu Val Thr Ser His Ile His Leu His Val Pro Glu 
        835                 840                 845             


Gly Ala Thr Pro Lys Asp Gly Pro Ser Ala Gly Cys Thr Ile Val Thr 
    850                 855                 860                 


Ala Leu Leu Ser Leu Ala Leu Asp Arg Pro Val Arg Gln Asn Leu Ala 
865                 870                 875                 880 


Met Thr Gly Glu Val Ser Leu Thr Gly Lys Val Leu Pro Val Gly Gly 
                885                 890                 895     


Ile Lys Glu Lys Thr Ile Ala Ala Lys Arg Ala Gly Val Thr Cys Ile 
            900                 905                 910         


Val Leu Pro Ala Glu Asn Lys Lys Asp Phe Tyr Asp Leu Ala Ala Phe 
        915                 920                 925             


Ile Thr Glu Gly Leu Glu Val His Phe Val Glu His Tyr Arg Glu Ile 
    930                 935                 940                 


Phe Asp Ile Ala Phe Pro Glu Glu Arg Ala Glu Ala Leu Ala Val Glu 
945                 950                 955                 960 


Arg 
    


<210>  55
<211>  849
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (40)..(44)
<223>  GXSXG lipase consensus

<400>  55

Met His Lys His Gln His Cys Cys Lys Cys Pro Glu Cys Tyr Glu Val 
1               5                   10                  15      


Thr Arg Leu Ala Ala Leu Arg Arg Leu Glu Pro Pro Gly Tyr Gly Asp 
            20                  25                  30          


Trp Gln Val Pro Asp Pro Tyr Gly Pro Ser Gly Gly Asn Gly Ala Ser 
        35                  40                  45              


Ser Gly Tyr Gly Gly Tyr Ser Ser Gln Thr Leu Pro Ser Gln Ala Gly 
    50                  55                  60                  


Ala Thr Pro Thr Pro Arg Thr Lys Ala Lys Leu Ile Pro Thr Gly Arg 
65                  70                  75                  80  


Asp Val Gly Pro Val Pro Pro Lys Pro Val Pro Gly Lys Ser Thr Pro 
                85                  90                  95      


Lys Leu Asn Gly Ser Gly Pro Gly Trp Trp Pro Glu Cys Thr Cys Thr 
            100                 105                 110         


Asn Arg Asp Trp Tyr Glu Gln Ala Ser Pro Ala Pro Leu Leu Val Asn 
        115                 120                 125             


Pro Glu Ala Leu Glu Pro Ser Leu Ser Val Asn Gly Ser Asp Gly Met 
    130                 135                 140                 


Phe Lys Tyr Glu Glu Ile Val Leu Glu Arg Gly Asn Ser Gly Leu Gly 
145                 150                 155                 160 


Phe Ser Ile Ala Gly Gly Ile Asp Asn Pro His Val Pro Asp Asp Pro 
                165                 170                 175     


Gly Ile Phe Ile Thr Lys Ile Ile Pro Gly Gly Ala Ala Ala Met Asp 
            180                 185                 190         


Gly Arg Leu Gly Val Asn Asp Cys Val Leu Arg Val Asn Glu Val Asp 
        195                 200                 205             


Val Ser Glu Val Val His Ser Arg Ala Val Glu Ala Leu Lys Glu Ala 
    210                 215                 220                 


Gly Pro Val Val Arg Leu Val Val Arg Arg Arg Gln Pro Pro Pro Glu 
225                 230                 235                 240 


Thr Ile Met Glu Val Asn Leu Leu Lys Gly Pro Lys Gly Leu Gly Phe 
                245                 250                 255     


Ser Ile Ala Gly Gly Ile Gly Asn Gln His Ile Pro Gly Asp Asn Ser 
            260                 265                 270         


Ile Tyr Ile Thr Lys Ile Ile Glu Gly Gly Ala Ala Gln Lys Asp Gly 
        275                 280                 285             


Arg Leu Gln Ile Gly Asp Arg Leu Leu Ala Val Asn Asn Thr Asn Leu 
    290                 295                 300                 


Gln Asp Val Arg His Glu Glu Ala Val Ala Ser Leu Lys Asn Thr Ser 
305                 310                 315                 320 


Asp Met Val Tyr Leu Lys Val Ala Lys Pro Gly Ser Ile His Leu Asn 
                325                 330                 335     


Asp Met Tyr Ala Pro Pro Asp Tyr Ala Ser Thr Phe Thr Ala Leu Ala 
            340                 345                 350         


Asp Asn His Ile Ser His Asn Ser Ser Leu Gly Tyr Leu Gly Ala Val 
        355                 360                 365             


Glu Ser Lys Val Thr Tyr Pro Ala Pro Pro Gln Val Pro Pro Thr Arg 
    370                 375                 380                 


Tyr Ser Pro Ile Pro Arg His Met Leu Ala Glu Glu Asp Phe Thr Arg 
385                 390                 395                 400 


Glu Pro Arg Lys Ile Ile Leu His Lys Gly Ser Thr Gly Leu Gly Phe 
                405                 410                 415     


Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile Phe Val Ser Phe Ile 
            420                 425                 430         


Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu Leu Arg Arg Gly Asp 
        435                 440                 445             


Arg Ile Leu Ser Val Asn Gly Val Asn Leu Arg Asn Ala Thr His Glu 
    450                 455                 460                 


Gln Ala Ala Ala Ala Leu Lys Arg Ala Gly Gln Ser Val Thr Ile Val 
465                 470                 475                 480 


Ala Gln Tyr Arg Pro Glu Glu Tyr Ser Arg Phe Glu Ser Lys Ile His 
                485                 490                 495     


Asp Leu Arg Glu Gln Met Met Asn Ser Ser Met Ser Ser Gly Ser Gly 
            500                 505                 510         


Ser Leu Arg Thr Ser Glu Lys Arg Ser Leu Tyr Val Arg Ala Leu Phe 
        515                 520                 525             


Asp Tyr Asp Arg Thr Arg Asp Ser Cys Leu Pro Ser Gln Gly Leu Ser 
    530                 535                 540                 


Phe Ser Tyr Gly Asp Ile Leu His Val Ile Asn Ala Ser Asp Asp Glu 
545                 550                 555                 560 


Trp Trp Gln Ala Arg Leu Val Thr Pro His Gly Glu Ser Glu Gln Ile 
                565                 570                 575     


Gly Val Ile Pro Ser Lys Lys Arg Val Glu Lys Lys Glu Arg Ala Arg 
            580                 585                 590         


Leu Lys Thr Val Lys Phe His Ala Arg Thr Gly Met Ile Glu Ser Asn 
        595                 600                 605             


Arg Asp Phe Pro Gly Leu Ser Asp Asp Tyr Tyr Gly Ala Lys Asn Leu 
    610                 615                 620                 


Lys Gly Val Thr Ser Asn Thr Ser Asp Ser Glu Ser Ser Ser Lys Gly 
625                 630                 635                 640 


Gln Glu Asp Ala Ile Leu Ser Tyr Glu Pro Val Thr Arg Gln Glu Ile 
                645                 650                 655     


His Tyr Ala Arg Pro Val Ile Ile Leu Gly Pro Met Lys Asp Arg Val 
            660                 665                 670         


Asn Asp Asp Leu Ile Ser Glu Phe Pro His Lys Phe Gly Ser Cys Val 
        675                 680                 685             


Pro His Thr Thr Arg Pro Arg Arg Asp Asn Glu Val Asp Gly Gln Asp 
    690                 695                 700                 


Tyr His Phe Val Val Ser Arg Glu Gln Met Glu Lys Asp Ile Gln Asp 
705                 710                 715                 720 


Asn Lys Phe Ile Glu Ala Gly Gln Phe Asn Asp Asn Leu Tyr Gly Thr 
                725                 730                 735     


Ser Ile Gln Ser Val Arg Ala Val Ala Glu Arg Gly Lys His Cys Ile 
            740                 745                 750         


Leu Asp Val Ser Gly Asn Ala Ile Lys Arg Leu Gln Gln Ala Gln Leu 
        755                 760                 765             


Tyr Pro Ile Ala Ile Phe Ile Lys Pro Lys Ser Ile Glu Ala Leu Met 
    770                 775                 780                 


Glu Met Asn Arg Arg Gln Thr Tyr Glu Gln Ala Asn Lys Ile Phe Asp 
785                 790                 795                 800 


Lys Ala Met Lys Leu Glu Gln Glu Phe Gly Glu Tyr Phe Thr Ala Ile 
                805                 810                 815     


Val Gln Gly Asp Ser Leu Glu Glu Ile Tyr Asn Lys Ile Lys Gln Ile 
            820                 825                 830         


Ile Glu Asp Gln Ser Gly His Tyr Ile Trp Val Pro Ser Pro Glu Lys 
        835                 840                 845             


Leu 
    


<210>  56
<211>  2367
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1120)..(1124)
<223>  GXSXG lipase consensus

<400>  56

Met Gly Thr Arg Gly Ala Val Met Pro Pro Pro Met Trp Gly Leu Leu 
1               5                   10                  15      


Gly Cys Cys Phe Val Cys Ala Trp Ala Leu Gly Gly Pro Arg Pro Ile 
            20                  25                  30          


Arg Ser Leu Pro Pro Leu Ser Ser Gln Val Lys Pro Gly Ser Val Pro 
        35                  40                  45              


Met Gln Val Pro Leu Glu Gly Ala Glu Ala Ala Leu Ala Tyr Leu Tyr 
    50                  55                  60                  


Ser Gly Asp Ala Gln Gln Leu Ser Gln Val Asn Cys Ser Glu Arg Tyr 
65                  70                  75                  80  


Glu Ala Arg Gly Ala Gly Ala Met Pro Gly Leu Pro Pro Ser Leu Gln 
                85                  90                  95      


Gly Ala Ala Gly Thr Leu Ala Gln Ala Ala Asn Phe Leu Asn Met Leu 
            100                 105                 110         


Leu Gln Ala Asn Asp Ile Arg Glu Ser Ser Val Glu Glu Asp Val Glu 
        115                 120                 125             


Trp Tyr Gln Ala Leu Val Arg Ser Val Ala Glu Gly Asp Pro Arg Val 
    130                 135                 140                 


Tyr Arg Ala Leu Leu Thr Phe Asn Pro Pro Pro Gly Ala Ser His Leu 
145                 150                 155                 160 


Gln Leu Ala Leu Gln Ala Thr Arg Thr Gly Glu Glu Thr Ile Leu Gln 
                165                 170                 175     


Asp Leu Ser Gly Asn Trp Val Gln Glu Glu Asn Pro Pro Gly Asp Leu 
            180                 185                 190         


Asp Thr Pro Ala Leu Lys Lys Arg Val Leu Thr Asn Asp Leu Gly Ser 
        195                 200                 205             


Leu Gly Ser Pro Lys Trp Pro Gln Ala Asp Gly Tyr Val Gly Asp Thr 
    210                 215                 220                 


Gln Gln Val Arg Leu Ser Pro Pro Phe Leu Glu Cys Gln Glu Gly Arg 
225                 230                 235                 240 


Leu Arg Pro Gly Trp Leu Ile Thr Leu Ser Ala Thr Phe Tyr Gly Leu 
                245                 250                 255     


Lys Pro Asp Leu Ser Pro Glu Val Arg Gly Gln Val Gln Met Asp Val 
            260                 265                 270         


Asp Leu Gln Ser Val Asp Ile Asn Gln Cys Ala Ser Gly Pro Gly Trp 
        275                 280                 285             


Tyr Ser Asn Thr His Leu Cys Asp Leu Asn Ser Thr Gln Cys Val Pro 
    290                 295                 300                 


Leu Glu Ser Gln Gly Phe Val Leu Gly Arg Tyr Leu Cys Arg Cys Arg 
305                 310                 315                 320 


Pro Gly Phe Tyr Gly Ala Ser Pro Ser Gly Gly Leu Glu Glu Ser Asp 
                325                 330                 335     


Phe Gln Thr Thr Gly Gln Phe Gly Phe Pro Glu Gly Arg Ser Gly Arg 
            340                 345                 350         


Leu Leu Gln Cys Leu Pro Cys Pro Glu Gly Cys Thr Ser Cys Met Asp 
        355                 360                 365             


Ala Thr Pro Cys Leu Val Glu Glu Ala Ala Val Leu Arg Ala Ala Val 
    370                 375                 380                 


Leu Ala Cys Gln Ala Cys Cys Met Leu Ala Ile Phe Leu Ser Met Leu 
385                 390                 395                 400 


Val Ser Tyr Arg Cys Arg Arg Asn Lys Arg Ile Trp Ala Ser Gly Val 
                405                 410                 415     


Val Leu Leu Glu Thr Val Leu Phe Gly Phe Leu Leu Leu Tyr Phe Pro 
            420                 425                 430         


Val Phe Ile Leu Tyr Phe Lys Pro Ser Val Phe Arg Cys Ile Ala Leu 
        435                 440                 445             


Arg Trp Val Arg Leu Leu Gly Phe Ala Ile Val Tyr Gly Thr Ile Ile 
    450                 455                 460                 


Leu Lys Leu Tyr Arg Val Leu Gln Leu Phe Leu Ser Arg Thr Ala Gln 
465                 470                 475                 480 


Arg Ser Ala Leu Leu Ser Ser Gly Arg Leu Leu Arg Arg Leu Gly Leu 
                485                 490                 495     


Leu Leu Leu Pro Val Leu Gly Phe Leu Ala Val Trp Thr Val Gly Ala 
            500                 505                 510         


Leu Glu Arg Gly Ile Gln His Ala Pro Leu Val Ile Arg Gly His Thr 
        515                 520                 525             


Pro Ser Gly Arg His Phe Tyr Leu Cys His His Asp Arg Trp Asp Tyr 
    530                 535                 540                 


Ile Met Val Val Ala Glu Leu Leu Leu Leu Cys Trp Gly Ser Phe Leu 
545                 550                 555                 560 


Cys Tyr Ala Thr Arg Ala Val Leu Ser Ala Phe His Glu Pro Arg Tyr 
                565                 570                 575     


Met Gly Ile Ala Leu His Asn Glu Leu Leu Leu Ser Ala Ala Phe His 
            580                 585                 590         


Thr Ala Arg Phe Val Leu Val Pro Ser Leu His Pro Asp Trp Thr Leu 
        595                 600                 605             


Leu Leu Phe Phe Phe His Thr His Ser Thr Val Thr Thr Thr Leu Ala 
    610                 615                 620                 


Leu Ile Phe Ile Pro Lys Phe Trp Lys Leu Gly Ala Pro Pro Arg Glu 
625                 630                 635                 640 


Glu Met Val Asp Glu Val Cys Glu Asp Glu Leu Asp Leu Gln His Ser 
                645                 650                 655     


Gly Ser Tyr Leu Gly Ser Ser Ile Ala Ser Ala Trp Ser Glu His Ser 
            660                 665                 670         


Leu Asp Pro Gly Asp Ile Arg Asp Glu Leu Lys Lys Leu Tyr Ala Gln 
        675                 680                 685             


Leu Glu Val His Lys Thr Lys Glu Met Ala Ala Asn Asn Pro His Leu 
    690                 695                 700                 


Pro Lys Lys Arg Gly Ser Ser Cys Gln Gly Leu Gly Arg Ser Phe Met 
705                 710                 715                 720 


Arg Tyr Leu Ala Glu Phe Pro Glu Ala Leu Ala Arg Gln His Ser Arg 
                725                 730                 735     


Asp Ser Gly Ser Pro Gly His Gly Ser Leu Pro Gly Ser Ser Arg Arg 
            740                 745                 750         


Arg Leu Leu Ser Ser Ser Leu Gln Glu Pro Glu Gly Thr Pro Ala Leu 
        755                 760                 765             


His Lys Ser Arg Ser Thr Tyr Asp Gln Arg Arg Glu Gln Asp Pro Pro 
    770                 775                 780                 


Leu Leu Asp Ser Leu Leu Arg Arg Lys Leu Ala Lys Lys Ala Ser Arg 
785                 790                 795                 800 


Thr Glu Ser Arg Glu Ser Val Glu Gly Pro Pro Ala Leu Gly Phe Arg 
                805                 810                 815     


Ser Ala Ser Ala His Asn Leu Thr Val Gly Glu Arg Leu Pro Arg Ala 
            820                 825                 830         


Arg Pro Ala Ser Leu Gln Lys Ser Leu Ser Val Ala Ser Ser Arg Glu 
        835                 840                 845             


Lys Ala Leu Leu Met Ala Ser Gln Ala Tyr Leu Glu Glu Thr Tyr Arg 
    850                 855                 860                 


Gln Ala Lys Glu Arg Glu Glu Arg Lys Lys Ala Lys Ala Ala Met Ala 
865                 870                 875                 880 


Ser Leu Val Arg Arg Pro Ser Ala Arg Arg Leu Glu Arg Pro Arg Gly 
                885                 890                 895     


Ala Pro Leu Ser Ala Pro Pro Ser Pro Ala Lys Ser Ser Ser Val Asp 
            900                 905                 910         


Ser Ser His Thr Ser Gly Arg Leu His Glu Glu Ala Arg Arg Arg Leu 
        915                 920                 925             


Pro His Pro Pro Ile Arg His Gln Val Ser Thr Pro Ile Leu Ala Leu 
    930                 935                 940                 


Ser Gly Gly Leu Gly Glu Pro Arg Met Leu Ser Pro Thr Ser Thr Leu 
945                 950                 955                 960 


Ala Pro Ala Leu Leu Pro Ala Leu Ala Pro Thr Pro Ala Pro Ala Leu 
                965                 970                 975     


Ala Pro Val Pro Val Ser Pro Gln Ser Pro Asn Leu Leu Thr Tyr Ile 
            980                 985                 990         


Cys Pro Trp Glu Asn Ala Glu Leu  Pro Ala Lys Gln Glu  Asn Val Pro 
        995                 1000                 1005             


Gln Glu  Gly Pro Ser Gly Pro  Glu Arg Gly His His  Ser Pro Ala 
    1010                 1015                 1020             


Pro Ala  Arg Ala Arg Leu Trp  Arg Ala Leu Ser Val  Ala Val Glu 
    1025                 1030                 1035             


Lys Ser  Arg Ala Gly Glu Asn  Glu Met Asp Ala Glu  Asp Ala His 
    1040                 1045                 1050             


His Gln  Arg Glu Ala Asn Asp  Val Asp Glu Asp Arg  Pro Lys Ile 
    1055                 1060                 1065             


Phe Pro  Lys Ser His Ser Leu  Lys Ala Pro Val Gln  Gln Gly Ser 
    1070                 1075                 1080             


Met Arg  Ser Leu Gly Leu Ala  Ile Lys Ala Leu Thr  Arg Ser Arg 
    1085                 1090                 1095             


Ser Thr  Tyr Arg Glu Lys Glu  Ser Val Glu Glu Ser  Pro Glu Gly 
    1100                 1105                 1110             


Gln Asn  Ser Gly Thr Ala Gly  Glu Ser Met Gly Ala  Pro Ser Arg 
    1115                 1120                 1125             


Ser Pro  Arg Leu Gly Arg Pro  Lys Ala Val Ser Lys  Gln Ala Ala 
    1130                 1135                 1140             


Leu Ile  Pro Ser Asp Asp Lys  Glu Ser Leu Gln Asn  Gln Gln Asn 
    1145                 1150                 1155             


Ala His  Thr Ser Arg Met Leu  Gln Val Cys Gln Arg  Glu Gly Ser 
    1160                 1165                 1170             


Arg Glu  Gln Glu Asp Arg Gly  Arg Arg Met Thr Gln  Gly Leu Gly 
    1175                 1180                 1185             


Glu Arg  Lys Ala Glu Arg Ala  Gly Lys Thr Gly Leu  Ala Met Leu 
    1190                 1195                 1200             


Arg Gln  Val Ser Arg Asp Lys  Asn Ile Lys Gln Ser  Lys Glu Thr 
    1205                 1210                 1215             


Pro Val  Gly Trp Gln Glu Leu  Pro Lys Ala Gly Leu  Gln Ser Leu 
    1220                 1225                 1230             


Gly Ser  Ala Asp His Arg Val  Ala Glu Val Cys Pro  Trp Glu Val 
    1235                 1240                 1245             


Thr Glu  Ser Glu Thr Arg Gln  Pro Asp Ser Gly Asn  Lys Ala Glu 
    1250                 1255                 1260             


Ile Cys  Pro Trp Glu Thr Ser  Glu Gly Ala Pro Glu  Ser Arg Ala 
    1265                 1270                 1275             


Leu Arg  Gln Asp Pro Gly Asp  Ser Gln Lys Lys Arg  Gly Glu Ala 
    1280                 1285                 1290             


Arg Gly  Lys Ser Glu Pro Ile  Asp Val Val Pro Met  Met Arg Lys 
    1295                 1300                 1305             


Lys Pro  Glu Arg Leu Val Arg  Glu Gln Glu Ala Val  Cys Pro Trp 
    1310                 1315                 1320             


Glu Ser  Ala Asp Arg Gly Gly  Leu Ser Pro Gly Ser  Ala Pro Gln 
    1325                 1330                 1335             


Asp Pro  Gly Arg Ile Arg Asp  Lys Ser Glu Ala Gly  Asp Ser Val 
    1340                 1345                 1350             


Glu Ala  Arg Lys Val Glu Lys  Pro Gly Trp Glu Ala  Ala Gly Pro 
    1355                 1360                 1365             


Glu Ala  His Thr Pro Asp Ile  Thr Lys Ala Glu Pro  Cys Pro Trp 
    1370                 1375                 1380             


Glu Ala  Ser Glu Gly Gly Glu  Asp Gly Lys Pro Ala  Gln Glu Ala 
    1385                 1390                 1395             


Val Lys  Asp Leu Pro Gln Glu  Lys Gln Lys Thr Arg  Lys Ala Thr 
    1400                 1405                 1410             


Phe Trp  Lys Glu Gln Lys Pro  Gly Gly Asp Leu Glu  Ser Leu Cys 
    1415                 1420                 1425             


Pro Trp  Glu Ser Thr Asp Phe  Arg Gly Pro Ser Ala  Val Ser Ile 
    1430                 1435                 1440             


Gln Ala  Pro Gly Ser Ser Glu  Cys Ser Gly Ser Leu  Gly Ser Gly 
    1445                 1450                 1455             


Ile Ala  Glu Val Cys Leu Trp  Glu Ala Gly Asp Ala  Pro Ala Ile 
    1460                 1465                 1470             


Gln Lys  Ala Glu Ile Cys Pro  Trp Glu Leu Asp Asp  Asn Val Met 
    1475                 1480                 1485             


Gly Gln  Glu Met Leu Ser Leu  Gly Thr Gly Arg Glu  Ser Leu Gln 
    1490                 1495                 1500             


Glu Lys  Glu Lys Ala Ser Arg  Lys Gly Ser Phe Gly  Glu Met Gly 
    1505                 1510                 1515             


Glu Gln  Thr Val Lys Ala Val  Gln Lys Leu Ser Gln  Gln Gln Glu 
    1520                 1525                 1530             


Ser Val  Cys Pro Arg Glu Ser  Thr Val Pro Gly His  Ser Ser Pro 
    1535                 1540                 1545             


Cys Leu  Asp Asn Ser Ser Ser  Lys Ala Gly Ser Gln  Phe Leu Cys 
    1550                 1555                 1560             


Asn Gly  Gly Ser Arg Ala Thr  Gln Val Cys Pro Gln  Glu Asp Leu 
    1565                 1570                 1575             


Arg Pro  Glu Ala Gln Glu Ala  Thr Pro Ala Lys Thr  Glu Ile Cys 
    1580                 1585                 1590             


Pro Trp  Glu Val Asn Glu Arg  Thr Arg Glu Glu Trp  Thr Ser Ala 
    1595                 1600                 1605             


Gln Val  Pro Arg Gly Gly Glu  Ser Gln Lys Asp Lys  Glu Lys Met 
    1610                 1615                 1620             


Pro Gly  Lys Ser Glu Ile Glu  Asp Val Thr Ala Trp  Glu Lys Pro 
    1625                 1630                 1635             


Glu Gly  Gln Ile Gln Lys Gln  Glu Ala Val Gly Pro  Trp Glu Ser 
    1640                 1645                 1650             


Val Asp  Pro Gly Ser Phe Ser  Pro Gln Pro Arg Pro  Gln Asp Thr 
    1655                 1660                 1665             


Glu Arg  Pro Gln Thr Leu Leu  Gln Met Ser Gly Ser  Val Gly Ser 
    1670                 1675                 1680             


Lys Ala  Ala Asp Ile Cys Pro  Leu Asp Val Glu Glu  Asn Leu Thr 
    1685                 1690                 1695             


Ala Gly  Lys Ala Glu Ile Cys  Pro Trp Glu Val Gly  Ala Gly Ala 
    1700                 1705                 1710             


Gly Glu  Glu Arg Ala Leu Gly  Ala Glu Ala Ile Arg  Lys Ser Pro 
    1715                 1720                 1725             


Asn Asp  Thr Gly Lys Val Ser  Ala Asp Leu Gly Pro  Arg Glu Arg 
    1730                 1735                 1740             


Ala Val  Thr Ala Pro Glu Lys  Pro Gln Lys Pro Thr  Pro Glu Trp 
    1745                 1750                 1755             


Glu Val  Ala Cys Pro Trp Gly  Ser Val Gly Pro Gly  Ala Cys Ser 
    1760                 1765                 1770             


Gln His  Pro Gly Thr Leu Asp  Ala Asp Gly Pro Lys  Ala Gly Phe 
    1775                 1780                 1785             


Gln Glu  Leu Asp His Met Gly  Cys Arg Pro Gly Glu  Val Cys Pro 
    1790                 1795                 1800             


Trp Glu  Ala Gln Glu Ala Ala  Thr Ser Glu Lys Ala  Lys Ile Cys 
    1805                 1810                 1815             


Pro Trp  Glu Val Ser Glu Gly  Thr Thr Gly Lys Gly  Leu Asp Gln 
    1820                 1825                 1830             


Lys Ala  Gly Ser Glu Ser Ala  Glu Gln Arg Glu Lys  Ala Leu Glu 
    1835                 1840                 1845             


Lys Gly  Arg Leu Thr Ser Leu  Gly Glu Asp Val Ser  Lys Gly Met 
    1850                 1855                 1860             


Ala Lys  Leu Cys Gln Gln Gln  Glu Thr Ile Cys Ile  Trp Glu Asn 
    1865                 1870                 1875             


Lys Asp  Leu Arg Glu Ser Pro  Ala Gln Ala Pro Lys  Ile Ser Asp 
    1880                 1885                 1890             


Leu Pro  Ser Ser Met Ser Ser  Glu Val Ala Glu Gly  His Ser Leu 
    1895                 1900                 1905             


Glu Ala  Thr Glu Lys Gly Asp  Leu Arg Gln Asp Pro  Lys Thr Gly 
    1910                 1915                 1920             


Ser Phe  Pro Glu His Ile Thr  Gln Glu Lys Ala Pro  Ala Ala Asp 
    1925                 1930                 1935             


Thr Glu  Glu Phe Thr Thr Glu  Asp Gly Glu Lys Thr  Ser His Glu 
    1940                 1945                 1950             


Leu Gln  Ser Val Cys Pro Trp  Glu Thr Thr Ala Pro  Ala Asp Ser 
    1955                 1960                 1965             


Val Ser  His Leu Asp Arg Gln  Arg Pro Asp Gln Pro  Lys Ala Ser 
    1970                 1975                 1980             


Ser Gln  Arg Leu Val Ser Thr  Gly Gly Arg Ala Ala  Asp Val Cys 
    1985                 1990                 1995             


Pro Trp  Asp Val Pro Asp Ala  Gly Val Tyr Lys Ser  Asp Ser Ser 
    2000                 2005                 2010             


Ala Lys  Ala Glu Thr Cys Pro  Trp Glu Val Thr Glu  Arg Ile Pro 
    2015                 2020                 2025             


Val Lys  Gly Val Ser Arg Gln  Asp Gly Lys Gly Asp  Ser Gln Glu 
    2030                 2035                 2040             


Glu Lys  Gly Arg Ala Pro Glu  Lys Ser Glu Pro Lys  Gly Val Pro 
    2045                 2050                 2055             


Val Gln  Lys Lys Pro Glu Met  Ala Asp Phe Arg Gln  Gln Glu Ala 
    2060                 2065                 2070             


Val Cys  Pro Trp Glu Ser Gln  Asp Gly Lys Gly Leu  Ser Pro Gln 
    2075                 2080                 2085             


Pro Ala  Pro Asp Ala Ser Asp  Arg Ser Arg Gly Ser  Ser Glu Ala 
    2090                 2095                 2100             


Ala Gly  Ser Val Glu Thr Arg  Val Ala Glu Val Cys  Leu Trp Glu 
    2105                 2110                 2115             


Val Val  Glu Ala Pro Ser Ala  Lys Lys Ala Glu Ile  Cys Pro Trp 
    2120                 2125                 2130             


Glu Ala  Gly Gly Gly Ala Ala  Glu Glu Gly Glu Gln  Glu Arg Glu 
    2135                 2140                 2145             


Ser Gln  Gly Gln Gly Glu Met  Phe Leu Gln Lys Ala  Gly Pro Gly 
    2150                 2155                 2160             


Gly Thr  Glu Glu His Phe Ser  Lys Ala Ala Ala Lys  Pro Arg Glu 
    2165                 2170                 2175             


Gln Glu  Ala Val Cys Pro Gly  Glu Gly Thr Gly Ser  Gly Gly Leu 
    2180                 2185                 2190             


Leu Pro  Gln Ser Gly Ala Leu  Asp Pro Glu Leu Lys  Val Ser Pro 
    2195                 2200                 2205             


Lys Glu  Ala Gly Ser Met Gly  Ser Arg Met Ala Glu  Leu Cys Gln 
    2210                 2215                 2220             


Trp Glu  Ile Thr Asp Pro Glu  Gly Asn Lys Ile Lys  Gly Thr Met 
    2225                 2230                 2235             


Ala Asp  Ile Cys Pro Gly Glu  Glu Thr Gly Val Pro  Ser Glu Glu 
    2240                 2245                 2250             


Ser Gly  Leu Leu Ala Leu Thr  Ala Thr Arg Arg Glu  Phe Phe Pro 
    2255                 2260                 2265             


Thr Ala  Pro Glu Lys Pro Leu  Cys Leu Leu Val His  Gly Pro Leu 
    2270                 2275                 2280             


Asp His  Phe Phe Pro Glu Ser  Lys Ile Pro Cys Pro  Lys Val Ser 
    2285                 2290                 2295             


Arg Pro  Ala Ser Thr Phe Thr  Leu Glu Gly Val Arg  Glu Leu Gln 
    2300                 2305                 2310             


Gly Pro  Ser Gly Leu Glu Pro  Arg Thr Ser Leu Ala  Pro Glu Pro 
    2315                 2320                 2325             


Ser Leu  Gln Glu Ala Glu Ser  Gln Ser Ser Ser Leu  Thr Glu Asp 
    2330                 2335                 2340             


Ser Gly  Gln Val Ala Phe Glu  Ala Gln Tyr Glu Glu  Phe Thr Pro 
    2345                 2350                 2355             


Pro Thr  Val Tyr Pro Trp Asp  Trp Glu 
    2360                 2365         


<210>  57
<211>  242
<212>  PRT
<213>  Bos taurus


<220>
<221>  MISC_FEATURE
<222>  (164)..(168)
<223>  GXSXG lipase consensus

<400>  57

Met Ala Ala Ala Ala Gly Glu Ala Arg Arg Val Leu Val Tyr Gly Gly 
1               5                   10                  15      


Arg Gly Ala Leu Gly Ser Arg Cys Val Gln Ala Phe Arg Ala Arg Asn 
            20                  25                  30          


Trp Trp Val Ala Ser Ile Asp Val Gln Glu Asn Glu Glu Ala Ser Ala 
        35                  40                  45              


Asn Val Val Val Lys Met Thr Asp Ser Phe Thr Glu Gln Ala Asp Gln 
    50                  55                  60                  


Val Thr Ala Glu Val Gly Lys Leu Leu Gly Thr Glu Lys Val Asp Ala 
65                  70                  75                  80  


Ile Leu Cys Val Ala Gly Gly Trp Ala Gly Gly Asn Ala Lys Ser Lys 
                85                  90                  95      


Ser Leu Phe Lys Asn Cys Asp Leu Met Trp Lys Gln Ser Val Trp Thr 
            100                 105                 110         


Ser Thr Ile Ser Ser His Leu Ala Thr Lys His Leu Lys Glu Gly Gly 
        115                 120                 125             


Leu Leu Thr Leu Ala Gly Ala Arg Ala Ala Leu Asp Gly Thr Pro Gly 
    130                 135                 140                 


Met Ile Gly Tyr Gly Met Ala Lys Ala Ala Val His Gln Leu Cys Gln 
145                 150                 155                 160 


Ser Leu Ala Gly Lys Ser Ser Gly Leu Pro Pro Gly Ala Ala Ala Val 
                165                 170                 175     


Ala Leu Leu Pro Val Thr Leu Asp Thr Pro Val Asn Arg Lys Ser Met 
            180                 185                 190         


Pro Glu Ala Asp Phe Ser Ser Trp Thr Pro Leu Glu Phe Leu Val Glu 
        195                 200                 205             


Thr Phe His Asp Trp Ile Thr Glu Lys Asn Arg Pro Ser Ser Gly Ser 
    210                 215                 220                 


Leu Ile Gln Val Val Thr Thr Glu Gly Lys Thr Glu Leu Thr Ala Ala 
225                 230                 235                 240 


Ser Pro 
        


<210>  58
<211>  353
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (210)..(214)
<223>  GXSXG lipase consensus

<400>  58

Met Glu Lys Thr Leu Glu Thr Val Pro Leu Glu Arg Lys Lys Arg Glu 
1               5                   10                  15      


Lys Glu Gln Phe Arg Lys Leu Phe Ile Gly Gly Leu Ser Phe Glu Thr 
            20                  25                  30          


Thr Glu Glu Ser Leu Arg Asn Tyr Tyr Glu Gln Trp Gly Lys Leu Thr 
        35                  40                  45              


Asp Cys Val Val Met Arg Asp Pro Ala Ser Lys Arg Ser Arg Gly Phe 
    50                  55                  60                  


Gly Phe Val Thr Phe Ser Ser Met Ala Glu Val Asp Ala Ala Met Ala 
65                  70                  75                  80  


Ala Arg Pro His Ser Ile Asp Gly Arg Val Val Glu Pro Lys Arg Ala 
                85                  90                  95      


Val Ala Arg Glu Glu Ser Gly Lys Pro Gly Ala His Val Thr Val Lys 
            100                 105                 110         


Lys Leu Phe Val Gly Gly Ile Lys Glu Asp Thr Glu Glu His His Leu 
        115                 120                 125             


Arg Asp Tyr Phe Glu Glu Tyr Gly Lys Ile Asp Thr Ile Glu Ile Ile 
    130                 135                 140                 


Thr Asp Arg Gln Ser Gly Lys Lys Arg Gly Phe Gly Phe Val Thr Phe 
145                 150                 155                 160 


Asp Asp His Asp Pro Val Asp Lys Ile Val Leu Gln Lys Tyr His Thr 
                165                 170                 175     


Ile Asn Gly His Asn Ala Glu Val Arg Lys Ala Leu Ser Arg Gln Glu 
            180                 185                 190         


Met Gln Glu Val Gln Ser Ser Arg Ser Gly Arg Gly Gly Asn Phe Gly 
        195                 200                 205             


Phe Gly Asp Ser Arg Gly Gly Gly Gly Asn Phe Gly Pro Gly Pro Gly 
    210                 215                 220                 


Ser Asn Phe Arg Gly Gly Ser Asp Gly Tyr Gly Ser Gly Arg Gly Phe 
225                 230                 235                 240 


Gly Asp Gly Tyr Asn Gly Tyr Gly Gly Gly Pro Gly Gly Gly Asn Phe 
                245                 250                 255     


Gly Gly Ser Pro Gly Tyr Gly Gly Gly Arg Gly Gly Tyr Gly Gly Gly 
            260                 265                 270         


Gly Pro Gly Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Tyr Asp 
        275                 280                 285             


Asn Tyr Gly Gly Gly Asn Tyr Gly Ser Gly Ser Tyr Asn Asp Phe Gly 
    290                 295                 300                 


Asn Tyr Asn Gln Gln Pro Ser Asn Tyr Gly Pro Met Lys Ser Gly Asn 
305                 310                 315                 320 


Phe Gly Gly Ser Arg Asn Met Gly Gly Pro Tyr Gly Gly Gly Asn Tyr 
                325                 330                 335     


Gly Pro Gly Gly Ser Gly Gly Ser Gly Gly Tyr Gly Gly Arg Ser Arg 
            340                 345                 350         


Tyr 
    


<210>  59
<211>  5
<212>  PRT
<213>  Artificial

<220>
<223>  Lipase consensus


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Gly Xaa Ser Xaa Gly 
1               5   


