                         SEQUENCE LISTING

<110>  PURDUE RESEARCH FOUNDATION
       HILL, CATHERINE A.
       WATTS, VAL J.
 
<120>  INSECT AND TICK G-PROTEIN COUPLED RECEPTOR AND USES THEREOF

<130>  PRF-P065-01-WO-E

<150>  61/555,645
<151>  2011-11-04

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  1239
<212>  DNA
<213>  Aedes aegypti

<400>  1
atgaatacga ttgggatttt ttggcgatat tggtttctct cgagagccct cacaaaccca       60

ctccaacaca agcaaacaac acaaccgaat tctaaccgac gccccgtctt ttcttctgct      120

tccctttccg ttgcaggtgt ttttctatcg attgtgatat ttctctccgt agccggtaat      180

attctagtgt gtatagcaat ctacaccgag cggagtctgc ggcggattgg gaatctcttc      240

ctggcgtcgc ttgccatcgc cgatctgttc gtggcatcgt tggtgatgac gttcgccggt      300

gtcaacgatt tactgggcta ctggatattc ggggcccagt tctgcgacac ctgggtggcg      360

ttcgatgtca tgtgttcaac cgcttccatc ctgaatctgt gcgccatctc gctggaccgg      420

tacatccaca tcaaggatcc gctcagatat ggccgctggg taacgcgccg ggttgccatc      480

gggacgatcg tcgtcatctg gctgctggcg gccctggtct cgtttgtgcc gatctcgctg      540

gacctgcacc gggacaagcg ggacgaaacg gacacctcgc tcatcatcaa cggcgtcaag      600

tacgaaacgt gcgccctgga cctgacgccc acctatgccg tcgtttctag ttgtataagt      660

ttctacgtac cttgtatagt tatgatcggg atctactgca gactctactg ctacgcccag      720

aagcacgtca aatcgatacg agcggtgacg aggccgggtg aaatcagcga gaagcgctac      780

cgcagcatac ggaggcccaa accgagcaaa aacaagctga aattgcggca gctggcccat      840

cacgcctctt cgccgtacca cgtgtcggac cacaaggcgg ccatcaccgt cggagtgatc      900

atgggagtgt ttctcgtctg ctgggtgccg ttcttctgtg taaatatcat cgccgcgttc      960

tgcaagacct gtatcgggcc gcagacgttc aaggtgctgt cctggctggg ctactctaac     1020

tcggccttca atccgattat ctactcgatc ttcaataccg agttccggga ggcgttcaag     1080

cggatcctga cgacgaggag ctcgtggtgc tgtgcgcagg agatgggcaa cattcatccg     1140

cggcacagcg accgctacgt gacggactac gcggccaaaa atgtggtcat gaactccggg     1200

cgatcgtccg ccgatctcga acaggtatcc gccatctga                            1239


<210>  2
<211>  412
<212>  PRT
<213>  Aedes aegypti

<400>  2

Met Asn Thr Ile Gly Ile Phe Trp Arg Tyr Trp Phe Leu Ser Arg Ala 
1               5                   10                  15      


Leu Thr Asn Pro Leu Gln His Lys Gln Thr Thr Gln Pro Asn Ser Asn 
            20                  25                  30          


Arg Arg Pro Val Phe Ser Ser Ala Ser Leu Ser Val Ala Gly Val Phe 
        35                  40                  45              


Leu Ser Ile Val Ile Phe Leu Ser Val Ala Gly Asn Ile Leu Val Cys 
    50                  55                  60                  


Ile Ala Ile Tyr Thr Glu Arg Ser Leu Arg Arg Ile Gly Asn Leu Phe 
65                  70                  75                  80  


Leu Ala Ser Leu Ala Ile Ala Asp Leu Phe Val Ala Ser Leu Val Met 
                85                  90                  95      


Thr Phe Ala Gly Val Asn Asp Leu Leu Gly Tyr Trp Ile Phe Gly Ala 
            100                 105                 110         


Gln Phe Cys Asp Thr Trp Val Ala Phe Asp Val Met Cys Ser Thr Ala 
        115                 120                 125             


Ser Ile Leu Asn Leu Cys Ala Ile Ser Leu Asp Arg Tyr Ile His Ile 
    130                 135                 140                 


Lys Asp Pro Leu Arg Tyr Gly Arg Trp Val Thr Arg Arg Val Ala Ile 
145                 150                 155                 160 


Gly Thr Ile Val Val Ile Trp Leu Leu Ala Ala Leu Val Ser Phe Val 
                165                 170                 175     


Pro Ile Ser Leu Asp Leu His Arg Asp Lys Arg Asp Glu Thr Asp Thr 
            180                 185                 190         


Ser Leu Ile Ile Asn Gly Val Lys Tyr Glu Thr Cys Ala Leu Asp Leu 
        195                 200                 205             


Thr Pro Thr Tyr Ala Val Val Ser Ser Cys Ile Ser Phe Tyr Val Pro 
    210                 215                 220                 


Cys Ile Val Met Ile Gly Ile Tyr Cys Arg Leu Tyr Cys Tyr Ala Gln 
225                 230                 235                 240 


Lys His Val Lys Ser Ile Arg Ala Val Thr Arg Pro Gly Glu Ile Ser 
                245                 250                 255     


Glu Lys Arg Tyr Arg Ser Ile Arg Arg Pro Lys Pro Ser Lys Asn Lys 
            260                 265                 270         


Leu Lys Leu Arg Gln Leu Ala His His Ala Ser Ser Pro Tyr His Val 
        275                 280                 285             


Ser Asp His Lys Ala Ala Ile Thr Val Gly Val Ile Met Gly Val Phe 
    290                 295                 300                 


Leu Val Cys Trp Val Pro Phe Phe Cys Val Asn Ile Ile Ala Ala Phe 
305                 310                 315                 320 


Cys Lys Thr Cys Ile Gly Pro Gln Thr Phe Lys Val Leu Ser Trp Leu 
                325                 330                 335     


Gly Tyr Ser Asn Ser Ala Phe Asn Pro Ile Ile Tyr Ser Ile Phe Asn 
            340                 345                 350         


Thr Glu Phe Arg Glu Ala Phe Lys Arg Ile Leu Thr Thr Arg Ser Ser 
        355                 360                 365             


Trp Cys Cys Ala Gln Glu Met Gly Asn Ile His Pro Arg His Ser Asp 
    370                 375                 380                 


Arg Tyr Val Thr Asp Tyr Ala Ala Lys Asn Val Val Met Asn Ser Gly 
385                 390                 395                 400 


Arg Ser Ser Ala Asp Leu Glu Gln Val Ser Ala Ile 
                405                 410         


<210>  3
<211>  1431
<212>  DNA
<213>  Aedes aegypti

<400>  3
atgaataatg caactgactt ctactgggaa ctgtcgcaac tgataaggtt tagcaatctc       60

agctactaca atgtgtcaaa tggtggcgaa acttcggtga cactggatgc ggtcaactgc      120

tgtaccactg agccgaactt ctcagagtac ctggatgccc tgccaaacga cagggccgga      180

ttgttagcgt ttctgttcct gttttccttc gcaacagtct tcggtaactc gctggtaata      240

ctggctgtta tccgagagcg gtaccttcac acggcgacca attatttcgt gaccagcctg      300

gccgtggcgg actgcctggt aggactggtc gtgatgccgt tctctgcatt gtatgaggtg      360

ctgcagaata cgtggttctt cggtgaagat tggtgtgata tatggcgctc gttagatgta      420

ttgtttagta ctgcttccat actgaaccta tgtgtgatat ctcttgatcg gtactgggcc      480

ataacggatc cattttccta cccgatgaag atgactcgaa agaaggcagc tgccctaata      540

gcagctgtgt ggatatgctc aagtgcgatc agcttcccgg cgatcgtgtg gtggcgagct      600

gcacgggaag gcgatatgcc accgtacaag tgcacattta ccgagcatct cggctatttg      660

gtgttctcct ccaccatatc gttctatctt ccactgcttg taatggtgtt cacttattgt      720

agaatatacc gagctgcagc aatacaaact cgatcgctca agctgggaac caagcaagtg      780

ctgatggcat ccggtgaact acaacttacc ctccgaatac atcgaggtgg caccactcga      840

gaaaggccca accatcagca acagcaaccg ccgcagcacc aaacgcatca gcatcaagac      900

catcagcagc acacggcgaa ttcgacaccg gaagaaccgg acgaggaacc gctttccgcg      960

ctgcagaaca atggccttgg agggcgccat cggacgcaca tgggcaagaa cttttccctg     1020

tcgcgaaagc tggccaagtt tgccaaggag aagaaggccg ccaaaacgct cggcattgtg     1080

atgggtgtgt tcatagtttg ttggcttcca ttttttgtgg tgaacctgct gtcggggttt     1140

tgtatgcagt gtatagcgca cgaggaaatt gtgtcggccg tggtcacgtg gctggggtgg     1200

atcaattcca gtatgaatcc ggtgatctac gcgtgttgga gcagagattt cagaagggcc     1260

ttcgtgcgga tattgtgtgt ttgctgcccc agaaagatcc ggcgaaaata ccagccaaca     1320

atgcgctcga aagcgtctca gagatttgca tccagacggt gttactcgac gtgttccctg     1380

catgggatcc agcaagtacg tcaaaactct tgcgagcaga cgtatatcta g              1431


<210>  4
<211>  476
<212>  PRT
<213>  Aedes aegypti

<400>  4

Met Asn Asn Ala Thr Asp Phe Tyr Trp Glu Leu Ser Gln Leu Ile Arg 
1               5                   10                  15      


Phe Ser Asn Leu Ser Tyr Tyr Asn Val Ser Asn Gly Gly Glu Thr Ser 
            20                  25                  30          


Val Thr Leu Asp Ala Val Asn Cys Cys Thr Thr Glu Pro Asn Phe Ser 
        35                  40                  45              


Glu Tyr Leu Asp Ala Leu Pro Asn Asp Arg Ala Gly Leu Leu Ala Phe 
    50                  55                  60                  


Leu Phe Leu Phe Ser Phe Ala Thr Val Phe Gly Asn Ser Leu Val Ile 
65                  70                  75                  80  


Leu Ala Val Ile Arg Glu Arg Tyr Leu His Thr Ala Thr Asn Tyr Phe 
                85                  90                  95      


Val Thr Ser Leu Ala Val Ala Asp Cys Leu Val Gly Leu Val Val Met 
            100                 105                 110         


Pro Phe Ser Ala Leu Tyr Glu Val Leu Gln Asn Thr Trp Phe Phe Gly 
        115                 120                 125             


Glu Asp Trp Cys Asp Ile Trp Arg Ser Leu Asp Val Leu Phe Ser Thr 
    130                 135                 140                 


Ala Ser Ile Leu Asn Leu Cys Val Ile Ser Leu Asp Arg Tyr Trp Ala 
145                 150                 155                 160 


Ile Thr Asp Pro Phe Ser Tyr Pro Met Lys Met Thr Arg Lys Lys Ala 
                165                 170                 175     


Ala Ala Leu Ile Ala Ala Val Trp Ile Cys Ser Ser Ala Ile Ser Phe 
            180                 185                 190         


Pro Ala Ile Val Trp Trp Arg Ala Ala Arg Glu Gly Asp Met Pro Pro 
        195                 200                 205             


Tyr Lys Cys Thr Phe Thr Glu His Leu Gly Tyr Leu Val Phe Ser Ser 
    210                 215                 220                 


Thr Ile Ser Phe Tyr Leu Pro Leu Leu Val Met Val Phe Thr Tyr Cys 
225                 230                 235                 240 


Arg Ile Tyr Arg Ala Ala Ala Ile Gln Thr Arg Ser Leu Lys Leu Gly 
                245                 250                 255     


Thr Lys Gln Val Leu Met Ala Ser Gly Glu Leu Gln Leu Thr Leu Arg 
            260                 265                 270         


Ile His Arg Gly Gly Thr Thr Arg Glu Arg Pro Asn His Gln Gln Gln 
        275                 280                 285             


Gln Pro Pro Gln His Gln Thr His Gln His Gln Asp His Gln Gln His 
    290                 295                 300                 


Thr Ala Asn Ser Thr Pro Glu Glu Pro Asp Glu Glu Pro Leu Ser Ala 
305                 310                 315                 320 


Leu Gln Asn Asn Gly Leu Gly Gly Arg His Arg Thr His Met Gly Lys 
                325                 330                 335     


Asn Phe Ser Leu Ser Arg Lys Leu Ala Lys Phe Ala Lys Glu Lys Lys 
            340                 345                 350         


Ala Ala Lys Thr Leu Gly Ile Val Met Gly Val Phe Ile Val Cys Trp 
        355                 360                 365             


Leu Pro Phe Phe Val Val Asn Leu Leu Ser Gly Phe Cys Met Gln Cys 
    370                 375                 380                 


Ile Ala His Glu Glu Ile Val Ser Ala Val Val Thr Trp Leu Gly Trp 
385                 390                 395                 400 


Ile Asn Ser Ser Met Asn Pro Val Ile Tyr Ala Cys Trp Ser Arg Asp 
                405                 410                 415     


Phe Arg Arg Ala Phe Val Arg Ile Leu Cys Val Cys Cys Pro Arg Lys 
            420                 425                 430         


Ile Arg Arg Lys Tyr Gln Pro Thr Met Arg Ser Lys Ala Ser Gln Arg 
        435                 440                 445             


Phe Ala Ser Arg Arg Cys Tyr Ser Thr Cys Ser Leu His Gly Ile Gln 
    450                 455                 460                 


Gln Val Arg Gln Asn Ser Cys Glu Gln Thr Tyr Ile 
465                 470                 475     


<210>  5
<211>  1278
<212>  DNA
<213>  Ixodes scapularis

<400>  5
atgcagcctt cttcgtccag caccctgggt tccattgcga gcgtactacc caccttggag       60

gcagcggcca acaacaccac cgggatcggt caggacggcc aggtgtcctc cggccagctg      120

gacagttggg acctgtcctg ccgctacatc atcggcacct tcctctcact catcatcctg      180

acggccatca ccggcaacat tcttgtctgc ctggccatct acacggatcg ccggctccgc      240

aagctgggca acctcttcct cgtttctctg gccgtggccg acttgtttgt gtcctcactg      300

gtgatgacgt tcgcggtggt taacgacctc atgggatact gggcgttcgg cccccagttc      360

tgcgacatct ggattgcctt cgatgtgatg tgcagcacgg cgtccattct gaacttgtgc      420

gccatcagca tggaccgttt tctgcacatc aaggacccgc tgggctacgg ccgctggatg      480

accaagcgtg ccgtgctggg caccatctgt gccatctgga tgttgtcagc gttgatgtcg      540

tttctgccca tctcgctggg ctggcaccgg ccgtatccgg actcactgct tctggtcaac      600

ggactcacaa tgtgtgcgct ggacttgacg ccggagtacg cggtcacatc gtctctcatt      660

agcttctaca tgccctgcgt ggtcatggtg gcgttgtaca cgcggctcta cctgtacgcg      720

cgcaagcacg tgcagaacat ccgcgccgtc accaagccca tgaaccacaa agacatgagc      780

cccaccaagt tccgcagcat gggacagtcc tcgctgcacg tgatggacca caaagccgcc      840

atcacgctcg gaatcatcgt gggtgtgttc ctctgctgct gggtgccctt cttctgcgcc      900

aacattgtgg ccgccttctg caagacctgc atctccgaag attgcttcaa gtttctcacc      960

tggctgggct acctcaactc ggcgctcaac ccaatcatct acagcatctt caacacggag     1020

tttagggacg ccttccgcag ggtcatcacg gctcacgcat gctgcaaggc gctcgccgag     1080

agggcgaggg cacccagcga cctctcctat cgcaccaaga gaagcaccat ttgcgagacg     1140

cccagggcga acagtgtggc caattccgcg ggatgccgaa gcaacaacaa cactgccgaa     1200

cgcatttctc tccgcgccga agtcgacacc cgggtcgaga tcagcgtgaa gagcgtgggc     1260

gagatctcgg ccatatag                                                   1278


<210>  6
<211>  425
<212>  PRT
<213>  Ixodes scapularis

<400>  6

Met Gln Pro Ser Ser Ser Ser Thr Leu Gly Ser Ile Ala Ser Val Leu 
1               5                   10                  15      


Pro Thr Leu Glu Ala Ala Ala Asn Asn Thr Thr Gly Ile Gly Gln Asp 
            20                  25                  30          


Gly Gln Val Ser Ser Gly Gln Leu Asp Ser Trp Asp Leu Ser Cys Arg 
        35                  40                  45              


Tyr Ile Ile Gly Thr Phe Leu Ser Leu Ile Ile Leu Thr Ala Ile Thr 
    50                  55                  60                  


Gly Asn Ile Leu Val Cys Leu Ala Ile Tyr Thr Asp Arg Arg Leu Arg 
65                  70                  75                  80  


Lys Leu Gly Asn Leu Phe Leu Val Ser Leu Ala Val Ala Asp Leu Phe 
                85                  90                  95      


Val Ser Ser Leu Val Met Thr Phe Ala Val Val Asn Asp Leu Met Gly 
            100                 105                 110         


Tyr Trp Ala Phe Gly Pro Gln Phe Cys Asp Ile Trp Ile Ala Phe Asp 
        115                 120                 125             


Val Met Cys Ser Thr Ala Ser Ile Leu Asn Leu Cys Ala Ile Ser Met 
    130                 135                 140                 


Asp Arg Phe Leu His Ile Lys Asp Pro Leu Gly Tyr Gly Arg Trp Met 
145                 150                 155                 160 


Thr Lys Arg Ala Val Leu Gly Thr Ile Cys Ala Ile Trp Met Leu Ser 
                165                 170                 175     


Ala Leu Met Ser Phe Leu Pro Ile Ser Leu Gly Trp His Arg Pro Tyr 
            180                 185                 190         


Pro Asp Ser Leu Leu Leu Val Asn Gly Leu Thr Met Cys Ala Leu Asp 
        195                 200                 205             


Leu Thr Pro Glu Tyr Ala Val Thr Ser Ser Leu Ile Ser Phe Tyr Met 
    210                 215                 220                 


Pro Cys Val Val Met Val Ala Leu Tyr Thr Arg Leu Tyr Leu Tyr Ala 
225                 230                 235                 240 


Arg Lys His Val Gln Asn Ile Arg Ala Val Thr Lys Pro Met Asn His 
                245                 250                 255     


Lys Asp Met Ser Pro Thr Lys Phe Arg Ser Met Gly Gln Ser Ser Leu 
            260                 265                 270         


His Val Met Asp His Lys Ala Ala Ile Thr Leu Gly Ile Ile Val Gly 
        275                 280                 285             


Val Phe Leu Cys Cys Trp Val Pro Phe Phe Cys Ala Asn Ile Val Ala 
    290                 295                 300                 


Ala Phe Cys Lys Thr Cys Ile Ser Glu Asp Cys Phe Lys Phe Leu Thr 
305                 310                 315                 320 


Trp Leu Gly Tyr Leu Asn Ser Ala Leu Asn Pro Ile Ile Tyr Ser Ile 
                325                 330                 335     


Phe Asn Thr Glu Phe Arg Asp Ala Phe Arg Arg Val Ile Thr Ala His 
            340                 345                 350         


Ala Cys Cys Lys Ala Leu Ala Glu Arg Ala Arg Ala Pro Ser Asp Leu 
        355                 360                 365             


Ser Tyr Arg Thr Lys Arg Ser Thr Ile Cys Glu Thr Pro Arg Ala Asn 
    370                 375                 380                 


Ser Val Ala Asn Ser Ala Gly Cys Arg Ser Asn Asn Asn Thr Ala Glu 
385                 390                 395                 400 


Arg Ile Ser Leu Arg Ala Glu Val Asp Thr Arg Val Glu Ile Ser Val 
                405                 410                 415     


Lys Ser Val Gly Glu Ile Ser Ala Ile 
            420                 425 


<210>  7
<211>  1374
<212>  DNA
<213>  Ixodes scapularis

<400>  7
atgccagttc cgggcgagac gaacggctcg ctggacgagc cggcgtacag cctgctggaa       60

ctggtgtatg gcgcgaacct gtccgtgctc gagctggaga tcgtgcgcaa cgacagcgtg      120

gtggacatcg tgcgcgaggc ggcggttaac gtctcgctgt ccttcgtgga cgacgccggc      180

aacgcgagcg ggtccccgtt tccggacgag tcgacgcagg ggcagcacgt ggcgctcggc      240

gtactgctgg gcttcttctg cttcgtgacc atcttcggca atgtgctggt catgctgtcc      300

gtggcgaaag agcagtacct gcacacggtg accaactact tcatcgcgtc gctggcgacg      360

gcggactgcc tggtgggcgc cgtggtcatg cctttctcgg ccatccacga gatcatggac      420

aagtactgga tattcggcca ggatctgtgc gacgtgtggc actcgatcga cgtgctcgcc      480

agtacggcgt ccatcctcaa cctctgcgtc atatcgctgg atcgctattg ggctatcact      540

gatcccatca gctacccgtg ccgtatgacg caggccaagg cgaccaccct gatcgccgtc      600

gtctgggtct gctccgcgct catctccttc ccggccatcg cgtggtggcg cgccgtcaac      660

aagggtccgc cggccgcctt ccagtgcgcc ttcaccgacg acgtgggcta cctggtcttc      720

tcgtccacca tctccttcta cgccccgctc atggtcatgg tgttcaccta ctaccgcatc      780

taccgagccg ccgtcgaaca gacgcggaac ctcaagctcg gctcaaagca agtacagtcc      840

tgcaacggcg acgagaccac ttcggtcacg ctgcgaatcc accgcggggg aatgctgcag      900

gcagcgaaca actacaagac agtcttttcg acctcgaacg agtccttcga ccggaacaac      960

cttacggggg tgtccaggaa cctcaaaaac ttttcgctca gccgaaagct cgccaagctc     1020

gccaaggaac gcaaggccgc caagacgctc gccatcgtca tgggcgtgtt catcctgtgc     1080

tggctgccct tcttcgtcac caatatcctc atgggcatct gcggcgagaa ctgcgtcatg     1140

cagccggacc tcgtattctc cacagtgacc tggctcggct ggatcaactc cggcatgaac     1200

cccatcatct acgcctgctg gagcagggac ttccgacgag ctttcgccaa cgtgctctgc     1260

tgctgctgcc cgggctactt ccgccgacga cagcggcgaa gagaccgcct ccgacgcatc     1320

atcaaggaag acgcgagcat gcggtcgcag agcctagagg aggccgtcct atag           1374


<210>  8
<211>  457
<212>  PRT
<213>  Ixodes scapularis

<400>  8

Met Pro Val Pro Gly Glu Thr Asn Gly Ser Leu Asp Glu Pro Ala Tyr 
1               5                   10                  15      


Ser Leu Leu Glu Leu Val Tyr Gly Ala Asn Leu Ser Val Leu Glu Leu 
            20                  25                  30          


Glu Ile Val Arg Asn Asp Ser Val Val Asp Ile Val Arg Glu Ala Ala 
        35                  40                  45              


Val Asn Val Ser Leu Ser Phe Val Asp Asp Ala Gly Asn Ala Ser Gly 
    50                  55                  60                  


Ser Pro Phe Pro Asp Glu Ser Thr Gln Gly Gln His Val Ala Leu Gly 
65                  70                  75                  80  


Val Leu Leu Gly Phe Phe Cys Phe Val Thr Ile Phe Gly Asn Val Leu 
                85                  90                  95      


Val Met Leu Ser Val Ala Lys Glu Gln Tyr Leu His Thr Val Thr Asn 
            100                 105                 110         


Tyr Phe Ile Ala Ser Leu Ala Thr Ala Asp Cys Leu Val Gly Ala Val 
        115                 120                 125             


Val Met Pro Phe Ser Ala Ile His Glu Ile Met Asp Lys Tyr Trp Ile 
    130                 135                 140                 


Phe Gly Gln Asp Leu Cys Asp Val Trp His Ser Ile Asp Val Leu Ala 
145                 150                 155                 160 


Ser Thr Ala Ser Ile Leu Asn Leu Cys Val Ile Ser Leu Asp Arg Tyr 
                165                 170                 175     


Trp Ala Ile Thr Asp Pro Ile Ser Tyr Pro Cys Arg Met Thr Gln Ala 
            180                 185                 190         


Lys Ala Thr Thr Leu Ile Ala Val Val Trp Val Cys Ser Ala Leu Ile 
        195                 200                 205             


Ser Phe Pro Ala Ile Ala Trp Trp Arg Ala Val Asn Lys Gly Pro Pro 
    210                 215                 220                 


Ala Ala Phe Gln Cys Ala Phe Thr Asp Asp Val Gly Tyr Leu Val Phe 
225                 230                 235                 240 


Ser Ser Thr Ile Ser Phe Tyr Ala Pro Leu Met Val Met Val Phe Thr 
                245                 250                 255     


Tyr Tyr Arg Ile Tyr Arg Ala Ala Val Glu Gln Thr Arg Asn Leu Lys 
            260                 265                 270         


Leu Gly Ser Lys Gln Val Gln Ser Cys Asn Gly Asp Glu Thr Thr Ser 
        275                 280                 285             


Val Thr Leu Arg Ile His Arg Gly Gly Met Leu Gln Ala Ala Asn Asn 
    290                 295                 300                 


Tyr Lys Thr Val Phe Ser Thr Ser Asn Glu Ser Phe Asp Arg Asn Asn 
305                 310                 315                 320 


Leu Thr Gly Val Ser Arg Asn Leu Lys Asn Phe Ser Leu Ser Arg Lys 
                325                 330                 335     


Leu Ala Lys Leu Ala Lys Glu Arg Lys Ala Ala Lys Thr Leu Ala Ile 
            340                 345                 350         


Val Met Gly Val Phe Ile Leu Cys Trp Leu Pro Phe Phe Val Thr Asn 
        355                 360                 365             


Ile Leu Met Gly Ile Cys Gly Glu Asn Cys Val Met Gln Pro Asp Leu 
    370                 375                 380                 


Val Phe Ser Thr Val Thr Trp Leu Gly Trp Ile Asn Ser Gly Met Asn 
385                 390                 395                 400 


Pro Ile Ile Tyr Ala Cys Trp Ser Arg Asp Phe Arg Arg Ala Phe Ala 
                405                 410                 415     


Asn Val Leu Cys Cys Cys Cys Pro Gly Tyr Phe Arg Arg Arg Gln Arg 
            420                 425                 430         


Arg Arg Asp Arg Leu Arg Arg Ile Ile Lys Glu Asp Ala Ser Met Arg 
        435                 440                 445             


Ser Gln Ser Leu Glu Glu Ala Val Leu 
    450                 455         


