                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  LOW DENSITY LIPOPROTEIN -RELATED PROTEIN 6 (LRP6) - HALF LIFE 
       EXTENDER CONSTRUCTS

<130>  PAT054821

<150>  61/555,848
<151>  2011-11-04

<160>  336   

<170>  PatentIn version 3.5

<210>  1
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  1

Asp Tyr Val Ile Asn 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Homo Sapien

<400>  2

Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  15
<212>  PRT
<213>  Homo Sapien

<400>  3

Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp Val 
1               5                   10                  15  


<210>  4
<211>  10
<212>  PRT
<213>  Homo Sapien

<400>  4

Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
1               5                   10  


<210>  5
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  5

Lys Asn Asn Arg Pro Ser 
1               5       


<210>  6
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  6

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  7
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  7

Ser Trp Ser Gly Val Asn 
1               5       


<210>  8
<211>  15
<212>  PRT
<213>  Homo Sapien

<400>  8

Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp Val 
1               5                   10                  15  


<210>  9
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  9

Asp Ser Leu Arg Asn Lys 
1               5       


<210>  10
<211>  2
<212>  PRT
<213>  Homo Sapien

<400>  10

Lys Asn 
1       


<210>  11
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  11

Tyr Asp Gly Gln Lys Ser Leu 
1               5           


<210>  12
<211>  105
<212>  PRT
<213>  Homo Sapien

<400>  12

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  13
<211>  124
<212>  PRT
<213>  Homo Sapien

<400>  13

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  14
<211>  315
<212>  DNA
<213>  Homo Sapien

<400>  14
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgattctct tcgtaataag gtttattggt accagcagaa acccgggcag      120

gcgccagttc ttgtgattta taagaataat cgtccctcag gcatcccgga acgctttagc      180

ggatccaaca gcggcaacac cgcgaccctg accattagcg gcactcaggc ggaagacgaa      240

gcggattatt attgccagtc ttatgatggt cagaagtctc ttgtgtttgg cggcggcacg      300

aagttaaccg tccta                                                       315


<210>  15
<211>  372
<212>  DNA
<213>  Homo Sapien

<400>  15
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gattatgtta ttaattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atttcttggt ctggtgttaa tactcattat      180

gctgattctg ttaagggtcg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtcttggt      300

gctactgcta ataatattcg ttataagttt atggatgttt ggggccaagg caccctggtg      360

acggttagct ca                                                          372


<210>  16
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  16

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  17
<211>  454
<212>  PRT
<213>  Homo Sapien

<400>  17

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  18
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  18
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgattctct tcgtaataag gtttattggt accagcagaa acccgggcag      120

gcgccagttc ttgtgattta taagaataat cgtccctcag gcatcccgga acgctttagc      180

ggatccaaca gcggcaacac cgcgaccctg accattagcg gcactcaggc ggaagacgaa      240

gcggattatt attgccagtc ttatgatggt cagaagtctc ttgtgtttgg cggcggcacg      300

aagttaaccg tcctaggtca gcccaaggct gccccctcgg tcactctgtt cccgccctcc      360

tctgaggagc ttcaagccaa caaggccaca ctggtgtgtc tcataagtga cttctacccg      420

ggagccgtga cagtggcctg gaaggcagat agcagccccg tcaaggcggg agtggagacc      480

accacaccct ccaaacaaag caacaacaag tacgcggcca gcagctatct gagcctgacg      540

cctgagcagt ggaagtccca cagaagctac agctgccagg tcacgcatga agggagcacc      600

gtggagaaga cagtggcccc tacagaatgt tca                                   633


<210>  19
<211>  1362
<212>  DNA
<213>  Homo Sapien

<400>  19
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gattatgtta ttaattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atttcttggt ctggtgttaa tactcattat      180

gctgattctg ttaagggtcg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtcttggt      300

gctactgcta ataatattcg ttataagttt atggatgttt ggggccaagg caccctggtg      360

acggttagct cagcctccac caagggtcca tcggtcttcc ccctggcacc ctcctccaag      420

agcacctctg ggggcacagc ggccctgggc tgcctggtca aggactactt ccccgaaccg      480

gtgacggtgt cgtggaactc aggcgccctg accagcggcg tgcacacctt cccggctgtc      540

ctacagtcct caggactcta ctccctcagc agcgtggtga ccgtgccctc cagcagcttg      600

ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa ggtggacaag      660

agagttgagc ccaaatcttg tgacaaaact cacacatgcc caccgtgccc agcacctgaa      720

gcagcggggg gaccgtcagt cttcctcttc cccccaaaac ccaaggacac cctcatgatc      780

tcccggaccc ctgaggtcac atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc      840

aagttcaact ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag      900

gagcagtaca acagcacgta ccgggtggtc agcgtcctca ccgtcctgca ccaggactgg      960

ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag ccctcccagc ccccatcgag     1020

aaaaccatct ccaaagccaa agggcagccc cgagaaccac aggtgtacac cctgccccca     1080

tcccgggagg agatgaccaa gaaccaggtc agcctgacct gcctggtcaa aggcttctat     1140

cccagcgaca tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc     1200

acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct caccgtggac     1260

aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg tgatgcatga ggctctgcac     1320

aaccactaca cgcagaagag cctctccctg tctccgggta aa                        1362


<210>  20
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  20

Val Asn Gly Met His 
1               5   


<210>  21
<211>  16
<212>  PRT
<213>  Homo Sapien

<400>  21

Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  22
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  22

Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro 
1               5                   10      


<210>  23
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  23

Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val His 
1               5                   10      


<210>  24
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  24

Gly Asp Ser Asn Arg Pro Ser 
1               5           


<210>  25
<211>  10
<212>  PRT
<213>  Homo Sapien

<400>  25

Thr Arg Thr Ser Thr Pro Ile Ser Gly Val 
1               5                   10  


<210>  26
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  26

Gly Phe Thr Phe Ser Val Asn 
1               5           


<210>  27
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  27

Asp Gly Met Gly His 
1               5   


<210>  28
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  28

Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  29

Asp Asn Ile Gly Ser Lys Tyr 
1               5           


<210>  30
<211>  3
<212>  PRT
<213>  Homo Sapien

<400>  30

Gly Asp Ser 
1           


<210>  31
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  31

Thr Ser Thr Pro Ile Ser Gly 
1               5           


<210>  32
<211>  107
<212>  PRT
<213>  Homo Sapien

<400>  32

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  33
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  33

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  34
<211>  107
<212>  PRT
<213>  Homo Sapien

<400>  34

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  35
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  35

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  36
<211>  321
<212>  DNA
<213>  Homo Sapien

<400>  36
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgataatat tggttctaag tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatggtgat tctaatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg cactcgtact tctactccta tttctggtgt gtttggcggc      300

ggcacgaagt taaccgttct t                                                321


<210>  37
<211>  357
<212>  DNA
<213>  Homo Sapien

<400>  37
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gttaatggta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcgtt attgatggta tgggtcatac ttattatgct      180

gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg      240

caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg ttatgattat      300

attaagtatg gtgcttttga tccttggggc caaggcaccc tggtgacggt tagctca         357


<210>  38
<211>  212
<212>  PRT
<213>  Homo Sapien

<400>  38

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Ala 
    210         


<210>  39
<211>  221
<212>  PRT
<213>  Homo Sapien

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220     


<210>  40
<211>  636
<212>  DNA
<213>  Homo Sapien

<400>  40
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgataatat tggttctaag tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatggtgat tctaatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg cactcgtact tctactccta tttctggtgt gtttggcggc      300

ggcacgaagt taaccgttct tggccagccg aaagccgcac cgagtgtgac gctgtttccg      360

ccgagcagcg aagaattgca ggcgaacaaa gcgaccctgg tgtgcctgat tagcgacttt      420

tatccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgagggg      600

agcaccgtgg aaaaaaccgt tgcgccgact gaggcc                                636


<210>  41
<211>  663
<212>  DNA
<213>  Homo Sapien

<400>  41
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gttaatggta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcgtt attgatggta tgggtcatac ttattatgct      180

gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg      240

caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg ttatgattat      300

attaagtatg gtgcttttga tccttggggc caaggcaccc tggtgacggt tagctcagcg      360

tcgaccaaag gtccaagcgt gtttccgctg gctccgagca gcaaaagcac cagcggcggc      420

acggctgccc tgggctgcct ggttaaagat tatttcccgg aaccagtcac cgtgagctgg      480

aacagcgggg cgctgaccag cggcgtgcat acctttccgg cggtgctgca aagcagcggc      540

ctgtatagcc tgagcagcgt tgtgaccgtg ccgagcagca gcttaggcac tcagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agc                                                                    663


<210>  42
<211>  107
<212>  PRT
<213>  Homo Sapien

<400>  42

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  43
<211>  321
<212>  PRT
<213>  Homo Sapien

<400>  43

Ala Gly Cys Thr Ala Thr Gly Ala Ala Cys Thr Gly Ala Cys Cys Cys 
1               5                   10                  15      


Ala Gly Cys Cys Gly Cys Thr Gly Thr Cys Thr Gly Thr Gly Ala Gly 
            20                  25                  30          


Cys Gly Thr Gly Gly Cys Gly Cys Thr Gly Gly Gly Cys Cys Ala Gly 
        35                  40                  45              


Ala Cys Cys Gly Cys Gly Cys Gly Thr Ala Thr Thr Ala Cys Cys Thr 
    50                  55                  60                  


Gly Cys Gly Gly Thr Gly Gly Cys Gly Ala Thr Ala Ala Cys Ala Thr 
65                  70                  75                  80  


Thr Gly Gly Cys Ala Gly Cys Ala Ala Ala Thr Ala Thr Gly Thr Gly 
                85                  90                  95      


Cys Ala Thr Thr Gly Gly Thr Ala Thr Cys Ala Gly Cys Ala Gly Ala 
            100                 105                 110         


Ala Ala Cys Cys Gly Gly Gly Cys Cys Ala Gly Gly Cys Gly Cys Cys 
        115                 120                 125             


Gly Gly Thr Gly Cys Thr Gly Gly Thr Gly Ala Thr Thr Thr Ala Thr 
    130                 135                 140                 


Gly Gly Cys Gly Ala Thr Ala Gly Cys Ala Ala Cys Cys Gly Thr Cys 
145                 150                 155                 160 


Cys Gly Ala Gly Cys Gly Gly Cys Ala Thr Thr Cys Cys Gly Gly Ala 
                165                 170                 175     


Ala Cys Gly Thr Thr Thr Thr Ala Gly Cys Gly Gly Cys Ala Gly Cys 
            180                 185                 190         


Ala Ala Cys Ala Gly Cys Gly Gly Cys Ala Ala Cys Ala Cys Cys Gly 
        195                 200                 205             


Cys Gly Ala Cys Cys Cys Thr Gly Ala Cys Cys Ala Thr Thr Thr Cys 
    210                 215                 220                 


Thr Cys Gly Cys Gly Cys Gly Cys Ala Gly Gly Cys Gly Gly Gly Thr 
225                 230                 235                 240 


Gly Ala Thr Gly Ala Ala Gly Cys Gly Gly Ala Thr Thr Ala Thr Thr 
                245                 250                 255     


Ala Thr Thr Gly Cys Ala Cys Cys Cys Gly Thr Ala Cys Cys Ala Gly 
            260                 265                 270         


Cys Ala Cys Cys Cys Cys Gly Ala Thr Thr Ala Gly Cys Gly Gly Cys 
        275                 280                 285             


Gly Thr Gly Thr Thr Thr Gly Gly Cys Gly Gly Cys Gly Gly Thr Ala 
    290                 295                 300                 


Cys Gly Ala Ala Gly Thr Thr Ala Ala Cys Cys Gly Thr Thr Cys Thr 
305                 310                 315                 320 


Thr 
    


<210>  44
<211>  357
<212>  DNA
<213>  Homo Sapien

<400>  44
gaggtgcaat tgctggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gttaatggta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcgtt attgatggta tgggtcatac ttattatgct      180

gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg      240

caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg ttatgattat      300

attaagtatg gtgcttttga tccttggggc caaggcaccc tggtgacggt tagctca         357


<210>  45
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  45

Asp Tyr Ala Ile His 
1               5   


<210>  46
<211>  17
<212>  PRT
<213>  Homo Sapien

<400>  46

Gly Ile Ser Tyr Ser Gly Ser Ser Thr His Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  47
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  47

Gly Ser His Gly Asn Ile Met Ala Lys Arg Tyr Phe Asp Phe 
1               5                   10                  


<210>  48
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  48

Ser Gly Asp Asn Ile Arg Lys Lys Tyr Val Tyr 
1               5                   10      


<210>  49
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  49

Glu Asp Ser Lys Arg Pro Ser 
1               5           


<210>  50
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  50

Ser Thr Ala Asp Ser Gly Ile Asn Asn Gly Val 
1               5                   10      


<210>  51
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  51

Gly Phe Thr Phe Ser Asp Tyr 
1               5           


<210>  52
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  52

Ser Tyr Ser Gly Ser Ser 
1               5       


<210>  53
<211>  14
<212>  PRT
<213>  Homo Sapien

<400>  53

Gly Ser His Gly Asn Ile Met Ala Lys Arg Tyr Phe Asp Phe 
1               5                   10                  


<210>  54
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  54

Asp Asn Ile Arg Lys Lys Tyr 
1               5           


<210>  55
<211>  3
<212>  PRT
<213>  Homo Sapien

<400>  55

Glu Asp Ser 
1           


<210>  56
<211>  8
<212>  PRT
<213>  Homo Sapien

<400>  56

Ala Asp Ser Gly Ile Asn Asn Gly 
1               5               


<210>  57
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  57

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Arg Lys Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Ala Asp Ser Gly Ile Asn Asn 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  58
<211>  123
<212>  PRT
<213>  Homo Sapien

<400>  58

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Ser Gly Ser Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Gly Asn Ile Met Ala Lys Arg Tyr Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  59
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  59

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Arg Lys Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Ala Asp Ser Gly Ile Asn Asn 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  60
<211>  123
<212>  PRT
<213>  Homo Sapien

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Ser Gly Ser Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Gly Asn Ile Met Ala Lys Arg Tyr Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  61
<211>  324
<212>  DNA
<213>  Homo Sapien

<400>  61
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgataatat tcgtaagaag tatgtttatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgaggat tctaagcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ctctactgct gattctggta ttaataatgg tgtgtttggc      300

ggcggcacga agttaaccgt tctt                                             324


<210>  62
<211>  369
<212>  DNA
<213>  Homo Sapien

<400>  62
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gattatgcta ttcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatt ctggtagctc tacccattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggttct      300

catggtaata ttatggctaa gcgttatttt gatttttggg gccaaggcac cctggtgacg      360

gttagctca                                                              369


<210>  63
<211>  214
<212>  PRT
<213>  Homo Sapien

<400>  63

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Arg Lys Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Ala Asp Ser Gly Ile Asn Asn 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  64
<211>  453
<212>  PRT
<213>  Homo Sapien

<400>  64

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Ser Gly Ser Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Gly Asn Ile Met Ala Lys Arg Tyr Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala 
225                 230                 235                 240 


Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr 
                245                 250                 255     


Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val 
            260                 265                 270         


Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val 
        275                 280                 285             


Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser 
    290                 295                 300                 


Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu 
305                 310                 315                 320 


Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala 
                325                 330                 335     


Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro 
            340                 345                 350         


Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln 
        355                 360                 365             


Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala 
    370                 375                 380                 


Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr 
385                 390                 395                 400 


Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu 
                405                 410                 415     


Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser 
            420                 425                 430         


Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser 
        435                 440                 445             


Leu Ser Pro Gly Lys 
    450             


<210>  65
<211>  642
<212>  DNA
<213>  Homo Sapien

<400>  65
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgataatat tcgtaagaag tatgtttatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgaggat tctaagcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ctctactgct gattctggta ttaataatgg tgtgtttggc      300

ggcggcacga agttaaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  66
<211>  1359
<212>  DNA
<213>  Homo Sapien

<400>  66
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gattatgcta ttcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatt ctggtagctc tacccattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggttct      300

catggtaata ttatggccaa gcgttatttt gatttttggg gccaaggcac cctggtgacg      360

gttagctcag cctccaccaa gggtccatcg gtcttccccc tggcaccctc ctccaagagc      420

acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg      480

acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta      540

cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc      600

acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaga      660

gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaagca      720

gcggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc      780

cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag      840

ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag      900

cagtacaaca gcacgtaccg ggtggtcagc gtcctcaccg tcctgcacca ggactggctg      960

aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa     1020

accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc     1080

cgggaggaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc     1140

agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg     1200

cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag     1260

agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac     1320

cactacacgc agaagagcct ctccctgtct ccgggtaaa                            1359


<210>  67
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  67

Asn Arg Gly Gly Gly Val Gly 
1               5           


<210>  68
<211>  16
<212>  PRT
<213>  Homo Sapien

<400>  68

Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  69
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  69

Met His Leu Pro Leu Val Phe Asp Ser 
1               5                   


<210>  70
<211>  12
<212>  PRT
<213>  Homo Sapien

<400>  70

Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala 
1               5                   10          


<210>  71
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  71

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  72
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  72

Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr 
1               5                   


<210>  73
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  73

Gly Phe Ser Leu Ser Asn Arg Gly Gly 
1               5                   


<210>  74
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  74

Asp Trp Asp Asp Asp 
1               5   


<210>  75
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  75

Met His Leu Pro Leu Val Phe Asp Ser 
1               5                   


<210>  76
<211>  8
<212>  PRT
<213>  Homo Sapien

<400>  76

Ser Gln Phe Ile Gly Ser Arg Tyr 
1               5               


<210>  77
<211>  3
<212>  PRT
<213>  Homo Sapien

<400>  77

Gly Ala Ser 
1           


<210>  78
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  78

Tyr Tyr Asp Tyr Pro Gln 
1               5       


<210>  79
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  79

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  80
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  80

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  81
<211>  324
<212>  DNA
<213>  Homo Sapien

<400>  81
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcgactta ttattgccag cagtattatg attatcctca gacctttggc      300

cagggtacga aagttgaaat taaa                                             324


<210>  82
<211>  357
<212>  DNA
<213>  Homo Sapien

<400>  82
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctca         357


<210>  83
<211>  215
<212>  PRT
<213>  Homo Sapien

<400>  83

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  84
<211>  449
<212>  PRT
<213>  Homo Sapien

<400>  84

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  85
<211>  645
<212>  DNA
<213>  Homo Sapien

<400>  85
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcgactta ttattgccag cagtattatg attatcctca gacctttggc      300

cagggtacga aagttgaaat taaacgtacg gtggctgcac catctgtctt catcttcccg      360

ccatctgatg agcagttgaa atctggaact gcctctgttg tgtgcctgct gaataacttc      420

tatcccagag aggccaaagt acagtggaag gtggataacg ccctccaatc gggtaactcc      480

caggagagtg tcacagagca ggacagcaag gacagcacct acagcctcag cagcaccctg      540

acgctgagca aagcagacta cgagaaacac aaagtctacg cctgcgaagt cacccatcag      600

ggcctgagct cgcccgtcac aaagagcttc aacaggggag agtgt                      645


<210>  86
<211>  1347
<212>  DNA
<213>  Homo Sapien

<400>  86
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctcagcc      360

tccaccaagg gtccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc      420

acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      480

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      540

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac ccagacctac      600

atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagagagt tgagcccaaa      660

tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaagcagc ggggggaccg      720

tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag      780

gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac      840

gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc      900

acgtaccggg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag      960

tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa     1020

gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaggagatg     1080

accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc     1140

gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg     1200

gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag     1260

caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag     1320

aagagcctct ccctgtctcc gggtaaa                                         1347


<210>  87
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  87

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  88
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  88

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  89
<211>  357
<212>  DNA
<213>  Homo Sapien

<400>  89
caggtcacac tgaaagagtc cggccctgcc ctggtcaaac ccacccagac cctgaccctg       60

acatgcacct tcagcggctt cagcctgagc aacagaggcg gcggagtggg ctggatcaga      120

cagcctcccg gcaaggccct ggaatggctg gcctggatcg actgggacga cgacaagagc      180

tacagcacca gcctgaaaac ccggctgacc atcagcaagg acaccagcaa gaaccaggtg      240

gtgctgacca tgaccaacat ggaccccgtg gacaccgcca cctactactg cgcccggatg      300

catctgcccc tggtgttcga tagctggggc cagggcaccc tggtcaccgt cagctca         357


<210>  90
<211>  324
<212>  DNA
<213>  Homo Sapiens

<400>  90
gaaatcgtgc tgacccagag ccccgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc agcagatacc tggcttggta tcagcagaag      120

cccggccagg cccccagact gctgatctac ggcgccagca accgggccac cggcatccct      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccgtgta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggaaat caag                                             324


<210>  91
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  91

Asn Arg Gly Gly Gly Val Gly 
1               5           


<210>  92
<211>  16
<212>  PRT
<213>  Homo Sapien

<400>  92

Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr 
1               5                   10                  15      


<210>  93
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  93

Met His Leu Pro Leu Val Phe Asp Ser 
1               5                   


<210>  94
<211>  12
<212>  PRT
<213>  Homo Sapien

<400>  94

Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala 
1               5                   10          


<210>  95
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  95

Gly Ala Ser Asn Arg Ala Thr 
1               5           


<210>  96
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  96

Gln Gln Tyr Trp Ser Ile Pro Ile Thr 
1               5                   


<210>  97
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  97

Gly Phe Ser Leu Ser Asn Arg Gly Gly 
1               5                   


<210>  98
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  98

Asp Trp Asp Asp Asp 
1               5   


<210>  99
<211>  9
<212>  PRT
<213>  Homo Sapien

<400>  99

Met His Leu Pro Leu Val Phe Asp Ser 
1               5                   


<210>  100
<211>  8
<212>  PRT
<213>  Homo Sapien

<400>  100

Ser Gln Phe Ile Gly Ser Arg Tyr 
1               5               


<210>  101
<211>  3
<212>  PRT
<213>  Homo Sapien

<400>  101

Gly Ala Ser 
1           


<210>  102
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  102

Tyr Trp Ser Ile Pro Ile 
1               5       


<210>  103
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  103

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  104
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  104

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  105
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  105

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  106
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  106

Gln Val Thr Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  107
<211>  324
<212>  DNA
<213>  Homo Sapien

<400>  107
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcggtgta ttattgccag cagtattggt ctattcctat tacctttggc      300

cagggtacga aagttgaaat taaa                                             324


<210>  108
<211>  357
<212>  DNA
<213>  Homo Sapien

<400>  108
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctca         357


<210>  109
<211>  215
<212>  PRT
<213>  Homo Sapien

<400>  109

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Trp Ser Ile Pro 
                85                  90                  95      


Ile Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Ala 
    210                 215 


<210>  110
<211>  221
<212>  PRT
<213>  Homo Sapien

<400>  110

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220     


<210>  111
<211>  645
<212>  DNA
<213>  Homo Sapien

<400>  111
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcggtgta ttattgccag cagtattggt ctattcctat tacctttggc      300

cagggtacga aagttgaaat taaacgtacg gtggctgctc cgagcgtgtt tatttttccg      360

ccgagcgatg aacaactgaa aagcggcacg gcgagcgtgg tgtgcctgct gaacaacttt      420

tatccgcgtg aagcgaaagt tcagtggaaa gtagacaacg cgctgcaaag cggcaacagc      480

caggaaagcg tgaccgaaca ggatagcaaa gatagcacct attctctgag cagcaccctg      540

accctgagca aagcggatta tgaaaaacat aaagtgtatg cgtgcgaagt gacccatcaa      600

ggtctgagca gcccggtgac taaatctttt aatcgtggcg aggcc                      645


<210>  112
<211>  663
<212>  DNA
<213>  Homo Sapien

<400>  112
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctcagcg      360

tcgaccaaag gtccaagcgt gtttccgctg gctccgagca gcaaaagcac cagcggcggc      420

acggctgccc tgggctgcct ggttaaagat tatttcccgg aaccagtcac cgtgagctgg      480

aacagcgggg cgctgaccag cggcgtgcat acctttccgg cggtgctgca aagcagcggc      540

ctgtatagcc tgagcagcgt tgtgaccgtg ccgagcagca gcttaggcac tcagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agc                                                                    663


<210>  113
<211>  5
<212>  PRT
<213>  Homo Sapien

<400>  113

Ser Tyr Gly Met Ser 
1               5   


<210>  114
<211>  17
<212>  PRT
<213>  Homo Sapien

<400>  114

Asn Ile Ser Asn Asp Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  115
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  115

Phe Gln Ala Ser Tyr Leu Asp Ile Met Asp Tyr 
1               5                   10      


<210>  116
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  116

Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val His 
1               5                   10      


<210>  117
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  117

Asn Asp Ser Asn Arg Pro Ser 
1               5           


<210>  118
<211>  10
<212>  PRT
<213>  Homo Sapien

<400>  118

Gln Ala Trp Gly Asp Asn Gly Thr Arg Val 
1               5                   10  


<210>  119
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  119

Gly Phe Thr Phe Ser Ser Tyr 
1               5           


<210>  120
<211>  6
<212>  PRT
<213>  Homo Sapien

<400>  120

Ser Asn Asp Gly His Tyr 
1               5       


<210>  121
<211>  11
<212>  PRT
<213>  Homo Sapien

<400>  121

Phe Gln Ala Ser Tyr Leu Asp Ile Met Asp Tyr 
1               5                   10      


<210>  122
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  122

Asp Asn Ile Gly Ser Lys Tyr 
1               5           


<210>  123
<211>  3
<212>  PRT
<213>  Homo Sapien

<400>  123

Asn Asp Ser 
1           


<210>  124
<211>  7
<212>  PRT
<213>  Homo Sapien

<400>  124

Trp Gly Asp Asn Gly Thr Arg 
1               5           


<210>  125
<211>  107
<212>  PRT
<213>  Homo Sapien

<400>  125

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asn Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Asp Asn Gly Thr Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  126
<211>  120
<212>  PRT
<213>  Homo Sapien

<400>  126

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Ser Asn Asp Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Gln Ala Ser Tyr Leu Asp Ile Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  127
<211>  107
<212>  PRT
<213>  Homo Sapien

<400>  127

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asn Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Asp Asn Gly Thr Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  128
<211>  120
<212>  PRT
<213>  Homo Sapien

<400>  128

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Ser Asn Asp Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Gln Ala Ser Tyr Leu Asp Ile Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  129
<211>  321
<212>  DNA
<213>  Homo Sapien

<400>  129
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagag cattaccatc       60

tcgtgtagcg gcgataatat tggttctaag tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttataatgat tctaatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccaggcttgg ggtgataatg gtactcgtgt gtttggcggc      300

ggcacgaagt taaccgttct t                                                321


<210>  130
<211>  360
<212>  DNA
<213>  Homo Sapien

<400>  130
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct tcttatggta tgtcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcaat atttctaatg atggtcatta tacttattat      180

gctgattctg ttaagggtcg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgttttcag      300

gcttcttatc ttgatattat ggattattgg ggccaaggca ccctggtgac ggttagctca      360


<210>  131
<211>  212
<212>  PRT
<213>  Homo Sapien

<400>  131

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Ser Ile Thr Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asn Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Asp Asn Gly Thr Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Ala 
    210         


<210>  132
<211>  222
<212>  PRT
<213>  Homo Sapien

<400>  132

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Ser Asn Asp Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Gln Ala Ser Tyr Leu Asp Ile Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
    210                 215                 220         


<210>  133
<211>  636
<212>  DNA
<213>  Homo Sapien

<400>  133
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagag cattaccatc       60

tcgtgtagcg gcgataatat tggttctaag tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttataatgat tctaatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccaggcttgg ggtgataatg gtactcgtgt gtttggcggc      300

ggcacgaagt taaccgttct tggccagccg aaagccgcac cgagtgtgac gctgtttccg      360

ccgagcagcg aagaattgca ggcgaacaaa gcgaccctgg tgtgcctgat tagcgacttt      420

tatccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgagggg      600

agcaccgtgg aaaaaaccgt tgcgccgact gaggcc                                636


<210>  134
<211>  666
<212>  DNA
<213>  Homo Sapien

<400>  134
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct tcttatggta tgtcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcaat atttctaatg atggtcatta tacttattat      180

gctgattctg ttaagggtcg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgttttcag      300

gcttcttatc ttgatattat ggattattgg ggccaaggca ccctggtgac ggttagctca      360

gcgtcgacca aaggtccaag cgtgtttccg ctggctccga gcagcaaaag caccagcggc      420

ggcacggctg ccctgggctg cctggttaaa gattatttcc cggaaccagt caccgtgagc      480

tggaacagcg gggcgctgac cagcggcgtg catacctttc cggcggtgct gcaaagcagc      540

ggcctgtata gcctgagcag cgttgtgacc gtgccgagca gcagcttagg cactcagacc      600

tatatttgca acgtgaacca taaaccgagc aacaccaaag tggataaaaa agtggaaccg      660

aaaagc                                                                 666


<210>  135
<211>  107
<212>  PRT
<213>  Homo Sapien

<400>  135

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Gly Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asn Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Gly Asp Asn Gly Thr Arg 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  136
<211>  120
<212>  PRT
<213>  Homo Sapien

<400>  136

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Ser Asn Asp Gly His Tyr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Phe Gln Ala Ser Tyr Leu Asp Ile Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  137
<211>  321
<212>  DNA
<213>  Homo Sapien

<400>  137
agctatgaac tgacccagcc gctgagtgtt agcgttgcgc tgggtcagac cgcgcgtatt       60

acctgcggcg gtgataacat tggcagcaaa tatgtgcatt ggtatcagca gaaaccgggc      120

caggcgccgg tgctggtgat ttataacgat agcaaccgtc cgagcggcat tccggaacgt      180

tttagcggca gcaacagcgg caataccgcg accctgacca ttagccgtgc gcaggcgggt      240

gatgaagcgg attattattg ccaggcgtgg ggcgataatg gtacgcgtgt gtttggcggt      300

ggtacgaagt taaccgttct t                                                321


<210>  138
<211>  360
<212>  DNA
<213>  Homo Sapien

<400>  138
gaggtgcaat tgctggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct tcttatggta tgtcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcaat atttctaatg atggtcatta tacttattat      180

gctgattctg ttaagggtcg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgttttcag      300

gcttcttatc ttgatattat ggattattgg ggccaaggca ccctggtgac ggttagctca      360


<210>  139
<211>  726
<212>  DNA
<213>  Homo Sapien

<400>  139
gatatcgttc tgacccagag tccggcaacc ctgagcctga gtccgggtga acgtgccacc       60

ctgagctgtc gtgcaagcca gtttattggt agccgttatc tggcatggta tcagcagaaa      120

ccgggtcagg caccgcgtct gctgatttat ggtgcaagca atcgtgcaac cggtgttccg      180

gcacgtttta gcggtagcgg tagtggcacc gattttaccc tgaccattag cagcctggaa      240

ccggaagatt ttgcaaccta ttattgccag cagtattatg attatccgca gacctttggt      300

cagggcacca aggtggaaat taaaggtggt ggtggtagcg gtggtggtgg ctcaggtggt      360

ggcggtagtc aggttcaatt gaaagaaagc ggtccggcac tggttaaacc gacccagacc      420

ctgaccctga catgtacctt tagcggtttt agcctgagca atcgtggtgg tggtgttggt      480

tggattcgtc agcctccggg taaagcactg gaatggctgg catggattga ttgggatgat      540

gataaaagct atagcaccag cctgaaaacc cgtctgacca ttagtaaaga taccagcaaa      600

aatcaggtgg ttctgaccat gaccaatatg gatccggttg ataccgccac ctattattgt      660

gcacgtatgc atctgccgct ggtttttgat agctggggtc agggtacact agttaccgtt      720

agcagc                                                                 726


<210>  140
<211>  242
<212>  PRT
<213>  Homo Sapien

<400>  140

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys 
        115                 120                 125             


Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr 
    130                 135                 140                 


Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val Gly 
145                 150                 155                 160 


Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp Ile 
                165                 170                 175     


Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg Leu 
            180                 185                 190         


Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr 
        195                 200                 205             


Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met His 
    210                 215                 220                 


Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
225                 230                 235                 240 


Ser Ser 
        


<210>  141
<211>  741
<212>  DNA
<213>  Homo Sapien

<400>  141
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggatccg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag c                                                741


<210>  142
<211>  247
<212>  PRT
<213>  Homo Sapien

<400>  142

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser 
                245         


<210>  143
<211>  726
<212>  DNA
<213>  Homo Sapien

<400>  143
caggttcaat tgaaagaaag cggtccggca ctggttaaac cgacccagac cctgaccctg       60

acatgtacct ttagcggttt tagcctgagc aatcgtggtg gtggtgttgg ttggattcgt      120

cagcctccgg gtaaagcact ggaatggctg gcatggattg attgggatga tgataaaagc      180

tatagcacca gcctgaaaac ccgtctgacc attagcaaag ataccagcaa aaatcaggtt      240

gttctgacca tgaccaatat ggatccggtt gataccgcaa cctattattg tgcacgtatg      300

catctgccgc tggtttttga tagctggggt cagggtacac tagttaccgt tagcagcggt      360

ggtggtggta gcggtggtgg cggttcaggt ggtggtggca gtgatatcgt tctgacccag      420

agtccggcaa ccctgagcct gagtccgggt gaacgtgcca ccctgagctg tcgtgcaagc      480

cagtttattg gtagccgtta tctggcatgg tatcagcaga aaccgggtca ggcaccgcgt      540

ctgctgattt atggtgcaag caatcgtgca accggtgttc cggcacgttt tagcggtagc      600

ggtagtggca ccgattttac cctgaccatt agtagcctgg aaccggaaga ttttgccacc      660

tattattgcc agcagtatta tgattatccg cagacctttg gtcagggcac caaggtggaa      720

attaaa                                                                 726


<210>  144
<211>  242
<212>  PRT
<213>  Homo Sapien

<400>  144

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr 
    130                 135                 140                 


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
145                 150                 155                 160 


Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
                165                 170                 175     


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly 
            180                 185                 190         


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
        195                 200                 205             


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
    210                 215                 220                 


Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu 
225                 230                 235                 240 


Ile Lys 
        


<210>  145
<211>  741
<212>  DNA
<213>  Homo Sapien

<400>  145
caggttcaat tgaaagaaag cggtccggca ctggttaaac cgacccagac cctgaccctg       60

acatgtacct ttagcggttt tagcctgagc aatcgtggtg gtggtgttgg ttggattcgt      120

cagcctccgg gtaaagcact ggaatggctg gcatggattg attgggatga tgataaaagc      180

tatagcacca gcctgaaaac ccgtctgacc attagcaaag ataccagcaa aaatcaggtt      240

gttctgacca tgaccaatat ggatccggtt gataccgcaa cctattattg tgcacgtatg      300

catctgccgc tggtttttga tagctggggt cagggtacac tagttaccgt tagcagcggt      360

ggtggtggta gcggtggtgg cggttcaggt ggtggtggca gtggcggtgg tggtagtgat      420

atcgttctga cccagagtcc ggcaaccctg agcctgagtc cgggtgaacg tgccaccctg      480

agctgtcgtg caagccagtt tattggtagc cgttatctgg catggtatca gcagaaaccg      540

ggtcaggcac cgcgtctgct gatttatggt gcaagcaatc gtgcaaccgg tgttccggca      600

cgttttagcg gtagcggtag tggcaccgat tttaccctga ccattagtag cctggaaccg      660

gaagattttg ccacctatta ttgccagcag tattatgatt atccgcagac ctttggtcag      720

ggcaccaagg tggaaattaa a                                                741


<210>  146
<211>  247
<212>  PRT
<213>  Homo Sapien

<400>  146

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
    130                 135                 140                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
145                 150                 155                 160 


Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr 
                165                 170                 175     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
            180                 185                 190         


Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        195                 200                 205             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    210                 215                 220                 


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln 
225                 230                 235                 240 


Gly Thr Lys Val Glu Ile Lys 
                245         


<210>  147
<211>  732
<212>  DNA
<213>  Homo Sapien

<400>  147
gatatcgaac tgacccagcc tccgagcgtt agcgttgcac cgggtcagac cgcacgtatt       60

agctgtagcg gtgatagcct gcgtaataaa gtttattggt atcagcagaa accgggtcag      120

gcaccggttc tggttattta taaaaataat cgtccgagcg gtattccgga acgttttagc      180

ggtagcaata gcggtaatac cgcaaccctg accattagcg gcacccaggc agaagatgaa      240

gcagattatt attgccagag ctatgatggt cagaaaagcc tggtttttgg tggtggcacc      300

aagcttaccg ttctgggtgg tggtggtagc ggtggtggtg gctcaggtgg tggcggttct      360

caggttcaat tggttgaaag tggtggtggt ctggttcagc ctggtggtag cctgcgtctg      420

agctgtgcag caagcggttt tacctttagc gattatgtga ttaattgggt tcgccaggca      480

ccgggtaaag gtctggaatg ggttagcggt attagctggt caggtgttaa tacccattat      540

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      600

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      660

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      720

accgttagca gc                                                          732


<210>  148
<211>  244
<212>  PRT
<213>  Homo Sapien

<400>  148

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly 
        115                 120                 125             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    130                 135                 140                 


Ser Gly Phe Thr Phe Ser Asp Tyr Val Ile Asn Trp Val Arg Gln Ala 
145                 150                 155                 160 


Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Ser Gly Val 
                165                 170                 175     


Asn Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            180                 185                 190         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        195                 200                 205             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn 
    210                 215                 220                 


Asn Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val 
225                 230                 235                 240 


Thr Val Ser Ser 
                


<210>  149
<211>  747
<212>  DNA
<213>  Homo Sapien

<400>  149
gatatcgaac tgacccagcc tccgagcgtt agcgttgcac cgggtcagac cgcacgtatt       60

agctgtagcg gtgatagcct gcgtaataaa gtttattggt atcagcagaa accgggtcag      120

gcaccggttc tggttattta taaaaataat cgtccgagcg gtattccgga acgttttagc      180

ggtagcaata gcggtaatac cgcaaccctg accattagcg gcacccaggc agaagatgaa      240

gcagattatt attgccagag ctatgatggt cagaaaagcc tggtttttgg tggtggcacc      300

aagcttaccg ttctgggtgg tggtggtagc ggtggtggtg gctcaggtgg tggcggttct      360

ggtggcggtg gttcacaggt tcaattggtt gaaagtggtg gtggtctggt tcagcctggt      420

ggtagcctgc gtctgagctg tgcagcaagc ggttttacct ttagcgatta tgtgattaat      480

tgggttcgcc aggcaccggg taaaggtctg gaatgggtta gcggtattag ctggtcaggt      540

gttaataccc attatgcaga tagcgtgaaa ggtcgtttta ccattagccg tgataatagc      600

aaaaataccc tgtatctgca gatgaatagc ctgcgtgcag aagataccgc agtttattat      660

tgtgcacgtc tgggtgcaac cgcaaataat attcgctata aatttatgga tgtgtggggt      720

cagggtacac tagttaccgt tagcagc                                          747


<210>  150
<211>  249
<212>  PRT
<213>  Homo Sapien

<400>  150

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly 
            100                 105                 110         


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln 
        115                 120                 125             


Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg 
    130                 135                 140                 


Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Ile Asn 
145                 150                 155                 160 


Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Gly Ile 
                165                 170                 175     


Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val Lys Gly Arg 
            180                 185                 190         


Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met 
        195                 200                 205             


Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu 
    210                 215                 220                 


Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp Val Trp Gly 
225                 230                 235                 240 


Gln Gly Thr Leu Val Thr Val Ser Ser 
                245                 


<210>  151
<211>  732
<212>  DNA
<213>  Homo Sapien

<400>  151
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga ttaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg tggtagcggt ggtggcggat ctggtggcgg tggcagtgat      420

atcgaactga cccagcctcc gagcgttagc gttgcaccgg gtcagaccgc acgtattagc      480

tgtagcggtg atagtctgcg taataaagtt tattggtatc agcagaaacc gggtcaggct      540

ccggttctgg ttatttataa aaataatcgt ccgagcggta ttccggaacg ttttagcggt      600

agcaatagcg gtaataccgc aaccctgacc attagcggca cccaggcaga agatgaagcc      660

gattattatt gtcagagcta tgatggtcag aaaagcctgg tttttggtgg tggcaccaag      720

cttaccgttc tg                                                          732


<210>  152
<211>  244
<212>  PRT
<213>  Homo Sapien

<400>  152

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
145                 150                 155                 160 


Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr Trp Tyr Gln Gln Lys 
                165                 170                 175     


Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys Asn Asn Arg Pro Ser 
            180                 185                 190         


Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr 
        195                 200                 205             


Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe Gly Gly Gly Thr Lys 
225                 230                 235                 240 


Leu Thr Val Leu 
                


<210>  153
<211>  747
<212>  DNA
<213>  Homo Sapien

<400>  153
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga ttaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg tggtagcggt ggtggcggat ctggtggcgg tggttcaggt      420

ggtggtggca gtgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctg                                          747


<210>  154
<211>  249
<212>  PRT
<213>  Homo Sapien

<400>  154

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu 
                245                 


<210>  155
<211>  723
<212>  DNA
<213>  Homo Sapien

<400>  155
gatatcgaac tgacccagcc tccgagcgtt agcgttgcac cgggtcagac cgcacgtatt       60

agctgtagcg gtgataatat tggcagcaaa tatgtgcatt ggtatcagca gaaaccgggt      120

caggcaccgg ttctggttat ttatggtgat agcaatcgtc cgagcggtat tccggaacgt      180

tttagcggta gcaatagcgg taataccgca accctgacca ttagcggcac ccaggcagaa      240

gatgaagcag attattattg tacccgtacc agcaccccga ttagcggtgt ttttggtggt      300

ggcaccaagc ttaccgttct gggtggtggt ggtagcggtg gtggtggctc aggtggtggt      360

ggttcacagg ttcaattggt tgaaagtggt ggtggtctgg ttcagcctgg tggtagcctg      420

cgtctgagct gtgcagcaag cggttttacc tttagcgtta atggtatgca ttgggttcgc      480

caggcaccgg gtaaaggtct ggaatgggtt agcgttattg atggtatggg ccatacctat      540

tatgccgata gcgttaaagg tcgttttacc attagccgtg ataatagcaa aaataccctg      600

tatctgcaga tgaatagcct gcgtgcagaa gataccgcag tttattattg cgcacgctat      660

gattatatta aatatggtgc ctttgatccg tggggtcagg gtacactagt taccgttagc      720

agc                                                                    723


<210>  156
<211>  241
<212>  PRT
<213>  Homo Sapien

<400>  156

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu 
        115                 120                 125             


Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys 
    130                 135                 140                 


Ala Ala Ser Gly Phe Thr Phe Ser Val Asn Gly Met His Trp Val Arg 
145                 150                 155                 160 


Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Val Ile Asp Gly Met 
                165                 170                 175     


Gly His Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
            180                 185                 190         


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
        195                 200                 205             


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Tyr Asp Tyr Ile Lys 
    210                 215                 220                 


Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
225                 230                 235                 240 


Ser 
    


<210>  157
<211>  738
<212>  DNA
<213>  Homo Sapien

<400>  157
gatatcgaac tgacccagcc tccgagcgtt agcgttgcac cgggtcagac cgcacgtatt       60

agctgtagcg gtgataatat tggcagcaaa tatgtgcatt ggtatcagca gaaaccgggt      120

caggcaccgg ttctggttat ttatggtgat agcaatcgtc cgagcggtat tccggaacgt      180

tttagcggta gcaatagcgg taataccgca accctgacca ttagcggcac ccaggcagaa      240

gatgaagcag attattattg tacccgtacc agcaccccga ttagcggtgt ttttggtggt      300

ggcaccaagc ttaccgttct gggtggtggt ggtagcggtg gtggtggctc aggtggtggc      360

ggttctggtg gcggtggttc acaggttcaa ttggttgaaa gtggtggtgg tctggttcag      420

cctggtggta gcctgcgtct gagctgtgca gcaagcggtt ttacctttag cgttaatggt      480

atgcattggg ttcgccaggc accgggtaaa ggtctggaat gggttagcgt tattgatggt      540

atgggccata cctattatgc cgatagcgtt aaaggtcgtt ttaccattag ccgtgataat      600

agcaaaaata ccctgtatct gcagatgaat agcctgcgtg cagaagatac cgcagtttat      660

tattgcgcac gctatgatta tattaaatat ggtgcctttg atccgtgggg tcagggtaca      720

ctagttaccg ttagcagc                                                    738


<210>  158
<211>  246
<212>  PRT
<213>  Homo Sapien

<400>  158

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser 
            100                 105                 110         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln 
        115                 120                 125             


Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser 
    130                 135                 140                 


Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn Gly 
145                 150                 155                 160 


Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser 
                165                 170                 175     


Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys Gly 
            180                 185                 190         


Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 
        195                 200                 205             


Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
    210                 215                 220                 


Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly Thr 
225                 230                 235                 240 


Leu Val Thr Val Ser Ser 
                245     


<210>  159
<211>  723
<212>  DNA
<213>  Homo Sapien

<400>  159
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gttaatggta tgcattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcgtt attgatggta tgggccatac ctattatgcc      180

gatagcgtta aaggtcgttt taccattagc cgtgataata gcaaaaatac cctgtatctg      240

cagatgaata gcctgcgtgc agaagatacc gcagtttatt attgtgcccg ttatgattat      300

attaaatatg gtgcctttga tccgtggggt cagggtacac tagttaccgt tagcagtggt      360

ggtggtggta gcggtggtgg cggatctggt ggcggtggtt cagatatcga actgacccag      420

cctccgagcg ttagcgttgc accgggtcag accgcacgta ttagctgtag cggtgataat      480

attggcagca aatatgtgca ttggtatcag cagaaaccgg gtcaggctcc ggttctggtt      540

atttatggtg atagcaatcg tccgagcggt attccggaac gttttagcgg tagcaatagc      600

ggtaataccg caaccctgac cattagcggc acccaggcag aagatgaagc cgattattat      660

tgcacccgta ccagcacccc gattagcggt gtttttggtg gtggcaccaa gcttaccgtt      720

ctg                                                                    723


<210>  160
<211>  241
<212>  PRT
<213>  Homo Sapien

<400>  160

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val 
    130                 135                 140                 


Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn 
145                 150                 155                 160 


Ile Gly Ser Lys Tyr Val His Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
                165                 170                 175     


Pro Val Leu Val Ile Tyr Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro 
            180                 185                 190         


Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile 
        195                 200                 205             


Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr 
    210                 215                 220                 


Ser Thr Pro Ile Ser Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val 
225                 230                 235                 240 


Leu 
    


<210>  161
<211>  738
<212>  DNA
<213>  Homo Sapien

<400>  161
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gttaatggta tgcattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcgtt attgatggta tgggccatac ctattatgcc      180

gatagcgtta aaggtcgttt taccattagc cgtgataata gcaaaaatac cctgtatctg      240

cagatgaata gcctgcgtgc agaagatacc gcagtttatt attgtgcccg ttatgattat      300

attaaatatg gtgcctttga tccgtggggt cagggtacac tagttaccgt tagcagtggt      360

ggtggtggta gcggtggtgg cggatctggt ggcggtggtt caggtggtgg tggcagtgat      420

atcgaactga cccagcctcc gagcgttagc gttgcaccgg gtcagaccgc acgtattagc      480

tgtagcggtg ataatattgg cagcaaatat gtgcattggt atcagcagaa accgggtcag      540

gctccggttc tggttattta tggtgatagc aatcgtccga gcggtattcc ggaacgtttt      600

agcggtagca atagcggtaa taccgcaacc ctgaccatta gcggcaccca ggcagaagat      660

gaagccgatt attattgcac ccgtaccagc accccgatta gcggtgtttt tggtggtggc      720

accaagctta ccgttctg                                                    738


<210>  162
<211>  246
<212>  PRT
<213>  Homo Sapien

<400>  162

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr 
    130                 135                 140                 


Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser 
145                 150                 155                 160 


Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val His Trp Tyr Gln Gln 
                165                 170                 175     


Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Gly Asp Ser Asn Arg 
            180                 185                 190         


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
        195                 200                 205             


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly Val Phe Gly Gly Gly 
225                 230                 235                 240 


Thr Lys Leu Thr Val Leu 
                245     


<210>  163
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  163
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgtcc agcgtggtga cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agccccagag      720

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1020

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga agcgctgcac     1320

aaccactaca cccagaagag cctgagcctg tcccccggca agggcggctc cggcggaagc     1380

gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc     1440

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag     1500

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc     1560

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa     1620

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc     1680

cagggcacca aggtggagat caagggcgga ggcggatccg ggggtggcgg aagtggaggc     1740

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg     1800

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga     1860

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg     1920

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc     1980

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc     2040

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga     2100

accctggtga cagtgtccag c                                               2121


<210>  164
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  164

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  165
<211>  105
<212>  PRT
<213>  Homo Sapien

<400>  165

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  166
<211>  315
<212>  DNA
<213>  Homo Sapien

<400>  166
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctg                                                       315


<210>  167
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  167
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  168
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  168

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  169
<211>  706
<212>  PRT
<213>  Homo Sapien

<400>  169

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Gly Gly Ser Gly Gly Ser Asp Ile Val Leu Thr 
    450                 455                 460                 


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
465                 470                 475                 480 


Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr 
                485                 490                 495     


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
            500                 505                 510         


Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
        515                 520                 525             


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
    530                 535                 540                 


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln 
545                 550                 555                 560 


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                565                 570                 575     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys 
            580                 585                 590         


Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr 
        595                 600                 605             


Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val Gly 
    610                 615                 620                 


Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp Ile 
625                 630                 635                 640 


Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg Leu 
                645                 650                 655     


Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr 
            660                 665                 670         


Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met His 
        675                 680                 685             


Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
    690                 695                 700                 


Ser Ser 
705     


<210>  170
<211>  2118
<212>  PRT
<213>  Homo Sapien

<400>  170

Cys Ala Gly Gly Thr Gly Cys Ala Ala Thr Thr Gly Gly Thr Cys Gly 
1               5                   10                  15      


Ala Gly Thr Cys Thr Gly Gly Cys Gly Gly Ala Gly Gly Ala Cys Thr 
            20                  25                  30          


Gly Gly Thr Gly Cys Ala Gly Cys Cys Thr Gly Gly Thr Gly Gly Cys 
        35                  40                  45              


Ala Gly Cys Cys Thr Gly Ala Gly Ala Cys Thr Gly Ala Gly Cys Thr 
    50                  55                  60                  


Gly Cys Gly Cys Cys Gly Cys Cys Ala Gly Cys Gly Gly Cys Thr Thr 
65                  70                  75                  80  


Cys Ala Cys Cys Thr Thr Cys Ala Gly Cys Gly Ala Cys Thr Ala Cys 
                85                  90                  95      


Gly Thr Gly Ala Thr Cys Ala Ala Cys Thr Gly Gly Gly Thr Gly Cys 
            100                 105                 110         


Gly Ala Cys Ala Gly Gly Cys Cys Cys Cys Thr Gly Gly Ala Ala Ala 
        115                 120                 125             


Gly Gly Gly Cys Cys Thr Gly Gly Ala Ala Thr Gly Gly Gly Thr Gly 
    130                 135                 140                 


Thr Cys Cys Gly Gly Cys Ala Thr Cys Thr Cys Thr Thr Gly Gly Thr 
145                 150                 155                 160 


Cys Thr Gly Gly Cys Gly Thr Gly Ala Ala Cys Ala Cys Cys Cys Ala 
                165                 170                 175     


Cys Thr Ala Cys Gly Cys Cys Gly Ala Cys Ala Gly Cys Gly Thr Gly 
            180                 185                 190         


Ala Ala Gly Gly Gly Cys Cys Gly Gly Thr Thr Cys Ala Cys Cys Ala 
        195                 200                 205             


Thr Cys Ala Gly Cys Cys Gly Gly Gly Ala Cys Ala Ala Cys Ala Gly 
    210                 215                 220                 


Cys Ala Ala Gly Ala Ala Cys Ala Cys Cys Cys Thr Gly Thr Ala Cys 
225                 230                 235                 240 


Cys Thr Gly Cys Ala Gly Ala Thr Gly Ala Ala Cys Ala Gly Cys Cys 
                245                 250                 255     


Thr Gly Ala Gly Ala Gly Cys Cys Gly Ala Gly Gly Ala Cys Ala Cys 
            260                 265                 270         


Cys Gly Cys Cys Gly Thr Gly Thr Ala Cys Thr Ala Cys Thr Gly Thr 
        275                 280                 285             


Gly Cys Cys Ala Gly Ala Cys Thr Gly Gly Gly Cys Gly Cys Cys Ala 
    290                 295                 300                 


Cys Cys Gly Cys Cys Ala Ala Cys Ala Ala Cys Ala Thr Cys Cys Gly 
305                 310                 315                 320 


Gly Thr Ala Cys Ala Ala Gly Thr Thr Cys Ala Thr Gly Gly Ala Cys 
                325                 330                 335     


Gly Thr Gly Thr Gly Gly Gly Gly Cys Cys Ala Gly Gly Gly Cys Ala 
            340                 345                 350         


Cys Ala Cys Thr Gly Gly Thr Gly Ala Cys Cys Gly Thr Cys Ala Gly 
        355                 360                 365             


Cys Thr Cys Ala Gly Cys Thr Ala Gly Cys Ala Cys Cys Ala Ala Gly 
    370                 375                 380                 


Gly Gly Cys Cys Cys Cys Ala Gly Cys Gly Thr Gly Thr Thr Cys Cys 
385                 390                 395                 400 


Cys Cys Cys Thr Gly Gly Cys Cys Cys Cys Cys Ala Gly Cys Ala Gly 
                405                 410                 415     


Cys Ala Ala Gly Ala Gly Cys Ala Cys Cys Ala Gly Cys Gly Gly Cys 
            420                 425                 430         


Gly Gly Cys Ala Cys Ala Gly Cys Cys Gly Cys Cys Cys Thr Gly Gly 
        435                 440                 445             


Gly Cys Thr Gly Cys Cys Thr Gly Gly Thr Gly Ala Ala Gly Gly Ala 
    450                 455                 460                 


Cys Thr Ala Cys Thr Thr Cys Cys Cys Cys Gly Ala Gly Cys Cys Cys 
465                 470                 475                 480 


Gly Thr Gly Ala Cys Cys Gly Thr Gly Thr Cys Cys Thr Gly Gly Ala 
                485                 490                 495     


Ala Cys Ala Gly Cys Gly Gly Ala Gly Cys Cys Cys Thr Gly Ala Cys 
            500                 505                 510         


Cys Thr Cys Cys Gly Gly Cys Gly Thr Gly Cys Ala Cys Ala Cys Cys 
        515                 520                 525             


Thr Thr Cys Cys Cys Cys Gly Cys Cys Gly Thr Gly Cys Thr Gly Cys 
    530                 535                 540                 


Ala Gly Ala Gly Cys Ala Gly Cys Gly Gly Cys Cys Thr Gly Thr Ala 
545                 550                 555                 560 


Cys Ala Gly Cys Cys Thr Gly Thr Cys Cys Ala Gly Cys Gly Thr Gly 
                565                 570                 575     


Gly Thr Gly Ala Cys Ala Gly Thr Gly Cys Cys Cys Ala Gly Cys Ala 
            580                 585                 590         


Gly Cys Ala Gly Cys Cys Thr Gly Gly Gly Cys Ala Cys Cys Cys Ala 
        595                 600                 605             


Gly Ala Cys Cys Thr Ala Cys Ala Thr Cys Thr Gly Cys Ala Ala Cys 
    610                 615                 620                 


Gly Thr Gly Ala Ala Cys Cys Ala Cys Ala Ala Gly Cys Cys Cys Ala 
625                 630                 635                 640 


Gly Cys Ala Ala Cys Ala Cys Cys Ala Ala Gly Gly Thr Gly Gly Ala 
                645                 650                 655     


Cys Ala Ala Gly Ala Gly Ala Gly Thr Gly Gly Ala Gly Cys Cys Cys 
            660                 665                 670         


Ala Ala Gly Ala Gly Cys Thr Gly Cys Gly Ala Cys Ala Ala Gly Ala 
        675                 680                 685             


Cys Cys Cys Ala Cys Ala Cys Cys Thr Gly Cys Cys Cys Cys Cys Cys 
    690                 695                 700                 


Cys Thr Gly Cys Cys Cys Ala Gly Cys Cys Cys Cys Ala Gly Ala Gly 
705                 710                 715                 720 


Gly Cys Ala Gly Cys Gly Gly Gly Cys Gly Gly Ala Cys Cys Cys Thr 
                725                 730                 735     


Cys Cys Gly Thr Gly Thr Thr Cys Cys Thr Gly Thr Thr Cys Cys Cys 
            740                 745                 750         


Cys Cys Cys Cys Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly Ala Cys 
        755                 760                 765             


Ala Cys Cys Cys Thr Gly Ala Thr Gly Ala Thr Cys Ala Gly Cys Ala 
    770                 775                 780                 


Gly Gly Ala Cys Cys Cys Cys Cys Gly Ala Gly Gly Thr Gly Ala Cys 
785                 790                 795                 800 


Cys Thr Gly Cys Gly Thr Gly Gly Thr Gly Gly Thr Gly Gly Ala Cys 
                805                 810                 815     


Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Gly Gly Ala Cys Cys 
            820                 825                 830         


Cys Ala Gly Ala Gly Gly Thr Gly Ala Ala Gly Thr Thr Cys Ala Ala 
        835                 840                 845             


Cys Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly Cys 
    850                 855                 860                 


Gly Thr Gly Gly Ala Gly Gly Thr Gly Cys Ala Cys Ala Ala Cys Gly 
865                 870                 875                 880 


Cys Cys Ala Ala Gly Ala Cys Cys Ala Ala Gly Cys Cys Cys Ala Gly 
                885                 890                 895     


Ala Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Cys Ala Ala Cys 
            900                 905                 910         


Ala Gly Cys Ala Cys Cys Thr Ala Cys Ala Gly Gly Gly Thr Gly Gly 
        915                 920                 925             


Thr Gly Thr Cys Cys Gly Thr Gly Cys Thr Gly Ala Cys Cys Gly Thr 
    930                 935                 940                 


Gly Cys Thr Gly Cys Ala Cys Cys Ala Gly Gly Ala Cys Thr Gly Gly 
945                 950                 955                 960 


Cys Thr Gly Ala Ala Cys Gly Gly Cys Ala Ala Gly Gly Ala Ala Thr 
                965                 970                 975     


Ala Cys Ala Ala Gly Thr Gly Cys Ala Ala Gly Gly Thr Cys Thr Cys 
            980                 985                 990         


Cys Ala Ala Cys Ala Ala Gly Gly  Cys Cys Cys Thr Gly  Cys Cys Ala 
        995                 1000                 1005             


Gly Cys  Cys Cys Cys Cys Ala  Thr Cys Gly Ala Ala  Ala Ala Gly 
    1010                 1015                 1020             


Ala Cys  Cys Ala Thr Cys Ala  Gly Cys Ala Ala Gly  Gly Cys Cys 
    1025                 1030                 1035             


Ala Ala  Gly Gly Gly Cys Cys  Ala Gly Cys Cys Ala  Cys Gly Gly 
    1040                 1045                 1050             


Gly Ala  Gly Cys Cys Cys Cys  Ala Gly Gly Thr Gly  Thr Ala Cys 
    1055                 1060                 1065             


Ala Cys  Cys Cys Thr Gly Cys  Cys Cys Cys Cys Cys  Thr Cys Cys 
    1070                 1075                 1080             


Cys Gly  Gly Gly Ala Gly Gly  Ala Gly Ala Thr Gly  Ala Cys Cys 
    1085                 1090                 1095             


Ala Ala  Gly Ala Ala Cys Cys  Ala Gly Gly Thr Gly  Thr Cys Cys 
    1100                 1105                 1110             


Cys Thr  Gly Ala Cys Cys Thr  Gly Thr Cys Thr Gly  Gly Thr Gly 
    1115                 1120                 1125             


Ala Ala  Gly Gly Gly Cys Thr  Thr Cys Thr Ala Cys  Cys Cys Cys 
    1130                 1135                 1140             


Ala Gly  Cys Gly Ala Cys Ala  Thr Cys Gly Cys Cys  Gly Thr Gly 
    1145                 1150                 1155             


Gly Ala  Gly Thr Gly Gly Gly  Ala Gly Ala Gly Cys  Ala Ala Cys 
    1160                 1165                 1170             


Gly Gly  Cys Cys Ala Gly Cys  Cys Cys Gly Ala Gly  Ala Ala Cys 
    1175                 1180                 1185             


Ala Ala  Cys Thr Ala Cys Ala  Ala Gly Ala Cys Cys  Ala Cys Cys 
    1190                 1195                 1200             


Cys Cys  Cys Cys Cys Ala Gly  Thr Gly Cys Thr Gly  Gly Ala Cys 
    1205                 1210                 1215             


Ala Gly  Cys Gly Ala Cys Gly  Gly Cys Ala Gly Cys  Thr Thr Cys 
    1220                 1225                 1230             


Thr Thr  Cys Cys Thr Gly Thr  Ala Cys Ala Gly Cys  Ala Ala Gly 
    1235                 1240                 1245             


Cys Thr  Gly Ala Cys Cys Gly  Thr Gly Gly Ala Cys  Ala Ala Gly 
    1250                 1255                 1260             


Thr Cys  Cys Ala Gly Gly Thr  Gly Gly Cys Ala Gly  Cys Ala Gly 
    1265                 1270                 1275             


Gly Gly  Cys Ala Ala Cys Gly  Thr Gly Thr Thr Cys  Ala Gly Cys 
    1280                 1285                 1290             


Thr Gly  Cys Ala Gly Cys Gly  Thr Gly Ala Thr Gly  Cys Ala Cys 
    1295                 1300                 1305             


Gly Ala  Ala Gly Cys Gly Cys  Thr Gly Cys Ala Cys  Ala Ala Cys 
    1310                 1315                 1320             


Cys Ala  Cys Thr Ala Cys Ala  Cys Cys Cys Ala Gly  Ala Ala Gly 
    1325                 1330                 1335             


Ala Gly  Cys Cys Thr Gly Ala  Gly Cys Cys Thr Gly  Thr Cys Cys 
    1340                 1345                 1350             


Cys Cys  Cys Gly Gly Cys Gly  Gly Cys Gly Gly Cys  Thr Cys Cys 
    1355                 1360                 1365             


Gly Gly  Cys Gly Gly Ala Ala  Gly Cys Gly Ala Thr  Ala Thr Cys 
    1370                 1375                 1380             


Gly Thr  Gly Cys Thr Gly Ala  Cys Ala Cys Ala Gly  Ala Gly Cys 
    1385                 1390                 1395             


Cys Cys  Thr Gly Cys Cys Ala  Cys Cys Cys Thr Gly  Thr Cys Thr 
    1400                 1405                 1410             


Cys Thr  Gly Ala Gly Cys Cys  Cys Thr Gly Gly Cys  Gly Ala Gly 
    1415                 1420                 1425             


Ala Gly  Ala Gly Cys Cys Ala  Cys Cys Cys Thr Gly  Ala Gly Cys 
    1430                 1435                 1440             


Thr Gly  Cys Cys Gly Gly Gly  Cys Cys Ala Gly Cys  Cys Ala Gly 
    1445                 1450                 1455             


Thr Thr  Cys Ala Thr Cys Gly  Gly Cys Thr Cys Cys  Cys Gly Cys 
    1460                 1465                 1470             


Thr Ala  Cys Cys Thr Gly Gly  Cys Cys Thr Gly Gly  Thr Ala Thr 
    1475                 1480                 1485             


Cys Ala  Gly Cys Ala Gly Ala  Ala Gly Cys Cys Cys  Gly Gly Ala 
    1490                 1495                 1500             


Cys Ala  Gly Gly Cys Thr Cys  Cys Cys Ala Gly Ala  Cys Thr Gly 
    1505                 1510                 1515             


Cys Thr  Gly Ala Thr Cys Thr  Ala Cys Gly Gly Cys  Gly Cys Cys 
    1520                 1525                 1530             


Ala Gly  Cys Ala Ala Cys Ala  Gly Ala Gly Cys Thr  Ala Cys Cys 
    1535                 1540                 1545             


Gly Gly  Cys Gly Thr Gly Cys  Cys Cys Gly Cys Cys  Ala Gly Ala 
    1550                 1555                 1560             


Thr Thr  Thr Thr Cys Thr Gly  Gly Cys Ala Gly Cys  Gly Gly Cys 
    1565                 1570                 1575             


Ala Gly  Cys Gly Gly Cys Ala  Cys Cys Gly Ala Cys  Thr Thr Cys 
    1580                 1585                 1590             


Ala Cys  Cys Cys Thr Gly Ala  Cys Cys Ala Thr Cys  Ala Gly Cys 
    1595                 1600                 1605             


Ala Gly  Cys Cys Thr Gly Gly  Ala Ala Cys Cys Cys  Gly Ala Gly 
    1610                 1615                 1620             


Gly Ala  Cys Thr Thr Cys Gly  Cys Cys Ala Cys Cys  Thr Ala Cys 
    1625                 1630                 1635             


Thr Ala  Cys Thr Gly Cys Cys  Ala Gly Cys Ala Gly  Thr Ala Cys 
    1640                 1645                 1650             


Thr Ala  Cys Gly Ala Cys Thr  Ala Cys Cys Cys Cys  Cys Ala Gly 
    1655                 1660                 1665             


Ala Cys  Cys Thr Thr Cys Gly  Gly Cys Cys Ala Gly  Gly Gly Cys 
    1670                 1675                 1680             


Ala Cys  Cys Ala Ala Gly Gly  Thr Gly Gly Ala Gly  Ala Thr Cys 
    1685                 1690                 1695             


Ala Ala  Gly Gly Gly Cys Gly  Gly Ala Gly Gly Cys  Gly Gly Ala 
    1700                 1705                 1710             


Thr Cys  Cys Gly Gly Gly Gly  Gly Thr Gly Gly Cys  Gly Gly Ala 
    1715                 1720                 1725             


Ala Gly  Thr Gly Gly Ala Gly  Gly Cys Gly Gly Ala  Gly Gly Ala 
    1730                 1735                 1740             


Ala Gly  Cys Gly Gly Ala Gly  Gly Gly Gly Gly Cys  Gly Gly Ala 
    1745                 1750                 1755             


Ala Gly  Cys Cys Ala Gly Gly  Thr Gly Cys Ala Ala  Thr Thr Gly 
    1760                 1765                 1770             


Ala Ala  Ala Gly Ala Gly Thr  Cys Cys Gly Gly Cys  Cys Cys Thr 
    1775                 1780                 1785             


Gly Cys  Cys Cys Thr Gly Gly  Thr Gly Ala Ala Gly  Cys Cys Thr 
    1790                 1795                 1800             


Ala Cys  Cys Cys Ala Gly Ala  Cys Cys Cys Thr Gly  Ala Cys Cys 
    1805                 1810                 1815             


Cys Thr  Gly Ala Cys Ala Thr  Gly Cys Ala Cys Cys  Thr Thr Cys 
    1820                 1825                 1830             


Ala Gly  Cys Gly Gly Cys Thr  Thr Cys Ala Gly Cys  Cys Thr Gly 
    1835                 1840                 1845             


Ala Gly  Cys Ala Ala Cys Ala  Gly Ala Gly Gly Cys  Gly Gly Cys 
    1850                 1855                 1860             


Gly Gly  Ala Gly Thr Gly Gly  Gly Cys Thr Gly Gly  Ala Thr Cys 
    1865                 1870                 1875             


Ala Gly  Ala Cys Ala Gly Cys  Cys Thr Cys Cys Cys  Gly Gly Cys 
    1880                 1885                 1890             


Ala Ala  Gly Gly Cys Cys Cys  Thr Gly Gly Ala Ala  Thr Gly Gly 
    1895                 1900                 1905             


Cys Thr  Gly Gly Cys Cys Thr  Gly Gly Ala Thr Cys  Gly Ala Cys 
    1910                 1915                 1920             


Thr Gly  Gly Gly Ala Cys Gly  Ala Cys Gly Ala Cys  Ala Ala Gly 
    1925                 1930                 1935             


Ala Gly  Cys Thr Ala Cys Ala  Gly Cys Ala Cys Cys  Ala Gly Cys 
    1940                 1945                 1950             


Cys Thr  Gly Ala Ala Ala Ala  Cys Cys Cys Gly Gly  Cys Thr Gly 
    1955                 1960                 1965             


Ala Cys  Cys Ala Thr Cys Thr  Cys Cys Ala Ala Gly  Gly Ala Cys 
    1970                 1975                 1980             


Ala Cys  Cys Ala Gly Cys Ala  Ala Gly Ala Ala Cys  Cys Ala Gly 
    1985                 1990                 1995             


Gly Thr  Gly Gly Thr Gly Cys  Thr Cys Ala Cys Cys  Ala Thr Gly 
    2000                 2005                 2010             


Ala Cys  Cys Ala Ala Cys Ala  Thr Gly Gly Ala Cys  Cys Cys Cys 
    2015                 2020                 2025             


Gly Thr  Gly Gly Ala Cys Ala  Cys Cys Gly Cys Cys  Ala Cys Cys 
    2030                 2035                 2040             


Thr Ala  Thr Thr Ala Thr Thr  Gly Cys Gly Cys Cys  Cys Gly Gly 
    2045                 2050                 2055             


Ala Thr  Gly Cys Ala Thr Cys  Thr Gly Cys Cys Cys  Cys Thr Gly 
    2060                 2065                 2070             


Gly Thr  Gly Thr Thr Cys Gly  Ala Thr Ala Gly Cys  Thr Gly Gly 
    2075                 2080                 2085             


Gly Gly  Cys Cys Ala Gly Gly  Gly Ala Ala Cys Cys  Cys Thr Gly 
    2090                 2095                 2100             


Gly Thr  Gly Ala Cys Ala Gly  Thr Gly Thr Cys Cys  Ala Gly Cys 
    2105                 2110                 2115             


<210>  171
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  171

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Asp Ala Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  172
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  172
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgtcc agcgtggtga cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agccccagag      720

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1020

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga agcgctgcac     1320

aaccactaca cccagaagag cctgagcctg tcccccggca agggcggctc cggcggaagc     1380

gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc     1440

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag     1500

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc     1560

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa     1620

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc     1680

cagggcacca aggtggagat caagggcgga ggcggatccg ggggtggcgg aagtggaggc     1740

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg     1800

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga     1860

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg     1920

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc     1980

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggacgc cgtggacacc     2040

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga     2100

accctggtga cagtgtccag c                                               2121


<210>  173
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  173

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Thr Ala Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  174
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  174
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgtcc agcgtggtga cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agccccagag      720

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1020

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga agcgctgcac     1320

aaccactaca cccagaagag cctgagcctg tcccccggca agggcggctc cggcggaagc     1380

gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc     1440

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag     1500

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc     1560

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa     1620

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc     1680

cagggcacca aggtggagat caagggcgga ggcggatccg ggggtggcgg aagtggaggc     1740

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg     1800

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga     1860

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg     1920

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc     1980

aaggacacca gcaagaacca ggtggtgctc accatgacca acatgaccgc cgtggacacc     2040

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga     2100

accctggtga cagtgtccag c                                               2121


<210>  175
<211>  464
<212>  PRT
<213>  Homo Sapien

<400>  175

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Ser Gly Gly Ser Asp Ile Glu 
                245                 250                 255     


Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg 
            260                 265                 270         


Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr Trp Tyr Gln 
        275                 280                 285             


Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys Asn Asn Arg 
    290                 295                 300                 


Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr 
305                 310                 315                 320 


Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr 
                325                 330                 335     


Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe Gly Gly Gly 
            340                 345                 350         


Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro Ser Val Thr 
        355                 360                 365             


Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys Ala Thr Leu 
    370                 375                 380                 


Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr Val Ala Trp 
385                 390                 395                 400 


Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr Thr Thr Pro 
                405                 410                 415     


Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr Leu Ser Leu 
            420                 425                 430         


Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys Gln Val Thr 
        435                 440                 445             


His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr Glu Cys Ser 
    450                 455                 460                 


<210>  176
<211>  1392
<212>  DNA
<213>  Homo Sapien

<400>  176
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggatccg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cggcggctcc ggcggaagcg acatcgagct gacccagccc      780

ccttctgtgt ctgtggcgcc cgggcagacc gccagaatca gctgcagcgg cgacagcctg      840

cggaacaagg tgtactggta tcagcagaag cccggccagg ctcccgtgct ggtgatctac      900

aagaacaacc ggcccagcgg catccctgag cggttcagcg gcagcaacag cggcaatacc      960

gccaccctga ccatcagcgg cacccaggcc gaagatgagg ccgactacta ctgccagagc     1020

tacgacggcc agaaaagcct ggtgttcggc ggaggcacca agcttaccgt gctgggccag     1080

cccaaagccg cccctagcgt gaccctgttc ccccccagca gcgaggaact gcaggccaac     1140

aaggccaccc tggtctgcct gatcagcgac ttctaccctg gcgccgtgac cgtggcctgg     1200

aaggccgaca gcagccccgt gaaggccggc gtggagacaa ccacccccag caagcagagc     1260

aacaacaagt acgccgccag cagctacctg agcctgaccc ccgagcagtg gaagagccac     1320

agaagctaca gctgccaggt cacccacgag ggcagcaccg tggagaaaac cgtggccccc     1380

accgagtgca gc                                                         1392


<210>  177
<211>  124
<212>  PRT
<213>  Homo Sapien

<400>  177

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  178
<211>  372
<212>  DNA
<213>  Homo Sapien

<400>  178
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct ca                                                          372


<210>  179
<211>  454
<212>  PRT
<213>  Homo Sapien

<400>  179

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  180
<211>  1362
<212>  DNA
<213>  Homo Sapien

<400>  180
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgtcc agcgtggtga cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacacctgcc ccccctgccc agccccagag      720

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1020

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga ggccctgcac     1320

aaccactaca cccagaagag cctgagcctg tcccccggca ag                        1362


<210>  181
<211>  108
<212>  PRT
<213>  Homo Sapien

<400>  181

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


<210>  182
<211>  324
<212>  DNA
<213>  Homo Sapien

<400>  182
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcgactta ttattgccag cagtattatg attatcctca gacctttggc      300

cagggtacga aagttgaaat taaa                                             324


<210>  183
<211>  215
<212>  PRT
<213>  Homo Sapien

<400>  183

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  184
<211>  645
<212>  DNA
<213>  Homo Sapien

<400>  184
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcgactta ttattgccag cagtattatg attatcctca gacctttggc      300

cagggtacga aagttgaaat taaacgtacg gtggccgctc ccagcgtgtt catcttcccc      360

cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctgct gaacaacttc      420

tacccccggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggagagcg tcaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcat aaggtgtacg cctgcgaggt gacccaccag      600

ggcctgtcca gccccgtgac caagagcttc aacaggggcg agtgc                      645


<210>  185
<211>  699
<212>  PRT
<213>  Homo Sapien

<400>  185

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
    450                 455                 460                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 


Gly Phe Thr Phe Ser Asp Tyr Val Ile Asn Trp Val Arg Gln Ala Pro 
                485                 490                 495     


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Ser Gly Val Asn 
            500                 505                 510         


Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        515                 520                 525             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    530                 535                 540                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn 
545                 550                 555                 560 


Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
                565                 570                 575     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro 
        595                 600                 605             


Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys 
    610                 615                 620                 


Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile 
625                 630                 635                 640 


Tyr Lys Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
                645                 650                 655     


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
            660                 665                 670         


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu 
        675                 680                 685             


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    690                 695                 


<210>  186
<211>  2097
<212>  DNA
<213>  Homo Sapien

<400>  186
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctcagct      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgtccagcgt ggtgacagtg cccagcagca gcctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag      660

agctgcgaca agacccacac ctgccccccc tgcccagccc cagaggcagc gggcggaccc      720

tccgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag      780

gtgacctgcg tggtggtgga cgtgagccac gaggacccag aggtgaagtt caactggtac      840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc      900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      960

tacaagtgca aggtctccaa caaggccctg ccagccccca tcgaaaagac catcagcaag     1020

gccaagggcc agccacggga gccccaggtg tacaccctgc ccccctcccg ggaggagatg     1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg     1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagtc caggtggcag     1260

cagggcaacg tgttcagctg cagcgtgatg cacgaagcgc tgcacaacca ctacacccag     1320

aagagcctga gcctgtcccc cggcaagggc ggctccggcg gaagccaggt tcaattggtt     1380

gaaagcggtg gtggtctggt tcagcctggt ggtagcctgc gtctgagctg tgcagcaagc     1440

ggttttacct ttagcgatta tgtgattaat tgggttcgtc aggcaccggg taaaggtctg     1500

gaatgggtta gcggtattag ctggtcaggt gttaataccc attatgcaga tagcgtgaaa     1560

ggtcgtttta ccattagccg tgataatagc aaaaataccc tgtatctgca gatgaatagc     1620

ctgcgtgcag aagataccgc agtttattat tgtgcacgtc tgggtgcaac cgcaaataat     1680

attcgctata aatttatgga tgtgtggggt cagggtacac tagttaccgt tagcagtggt     1740

ggtggtggta gcggtggtgg cggatctggt ggcggtggca gtgatatcga actgacccag     1800

cctccgagcg ttagcgttgc accgggtcag accgcacgta ttagctgtag cggtgatagt     1860

ctgcgtaata aagtttattg gtatcagcag aaaccgggtc aggctccggt tctggttatt     1920

tataaaaata atcgtccgag cggtattccg gaacgtttta gcggtagcaa tagcggtaat     1980

accgcaaccc tgaccattag cggcacccag gcagaagatg aagccgatta ttattgtcag     2040

agctatgatg gtcagaaaag cctggttttt ggtggtggca ccaagcttac cgttctg        2097


<210>  187
<211>  704
<212>  PRT
<213>  Homo Sapien

<400>  187

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys Gly Gly Ser Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly 
    450                 455                 460                 


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
465                 470                 475                 480 


Gly Phe Thr Phe Ser Asp Tyr Val Ile Asn Trp Val Arg Gln Ala Pro 
                485                 490                 495     


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Ser Gly Val Asn 
            500                 505                 510         


Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
        515                 520                 525             


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
    530                 535                 540                 


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn 
545                 550                 555                 560 


Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
                565                 570                 575     


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            580                 585                 590         


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser 
        595                 600                 605             


Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp 
    610                 615                 620                 


Ser Leu Arg Asn Lys Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala 
625                 630                 635                 640 


Pro Val Leu Val Ile Tyr Lys Asn Asn Arg Pro Ser Gly Ile Pro Glu 
                645                 650                 655     


Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser 
            660                 665                 670         


Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp 
        675                 680                 685             


Gly Gln Lys Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
    690                 695                 700                 


<210>  188
<211>  2112
<212>  DNA
<213>  Homo Sapien

<400>  188
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctcagct      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgtccagcgt ggtgacagtg cccagcagca gcctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag      660

agctgcgaca agacccacac ctgccccccc tgcccagccc cagaggcagc gggcggaccc      720

tccgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag gacccccgag      780

gtgacctgcg tggtggtgga cgtgagccac gaggacccag aggtgaagtt caactggtac      840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc      900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggaa      960

tacaagtgca aggtctccaa caaggccctg ccagccccca tcgaaaagac catcagcaag     1020

gccaagggcc agccacggga gccccaggtg tacaccctgc ccccctcccg ggaggagatg     1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctaccccag cgacatcgcc     1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg     1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagtc caggtggcag     1260

cagggcaacg tgttcagctg cagcgtgatg cacgaagcgc tgcacaacca ctacacccag     1320

aagagcctga gcctgtcccc cggcaagggc ggctccggcg gaagccaggt tcaattggtt     1380

gaaagcggtg gtggtctggt tcagcctggt ggtagcctgc gtctgagctg tgcagcaagc     1440

ggttttacct ttagcgatta tgtgattaat tgggttcgtc aggcaccggg taaaggtctg     1500

gaatgggtta gcggtattag ctggtcaggt gttaataccc attatgcaga tagcgtgaaa     1560

ggtcgtttta ccattagccg tgataatagc aaaaataccc tgtatctgca gatgaatagc     1620

ctgcgtgcag aagataccgc agtttattat tgtgcacgtc tgggtgcaac cgcaaataat     1680

attcgctata aatttatgga tgtgtggggt cagggtacac tagttaccgt tagcagtggt     1740

ggtggtggta gcggtggtgg cggatctggt ggcggtggtt caggtggtgg tggcagtgat     1800

atcgaactga cccagcctcc gagcgttagc gttgcaccgg gtcagaccgc acgtattagc     1860

tgtagcggtg atagtctgcg taataaagtt tattggtatc agcagaaacc gggtcaggct     1920

ccggttctgg ttatttataa aaataatcgt ccgagcggta ttccggaacg ttttagcggt     1980

agcaatagcg gtaataccgc aaccctgacc attagcggca cccaggcaga agatgaagcc     2040

gattattatt gtcagagcta tgatggtcag aaaagcctgg tttttggtgg tggcaccaag     2100

cttaccgttc tg                                                         2112


<210>  189
<211>  105
<212>  PRT
<213>  Homo Sapien

<400>  189

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  190
<211>  315
<212>  DNA
<213>  Homo Sapien

<400>  190
gacatcgagc tgactcagcc ccctagcgtg tcagtggctc ctggccagac cgctagaatt       60

agctgtagcg gcgatagcct gcgtaacaag gtctactggt atcagcagaa gcccggccag      120

gcccctgtgc tggtcatcta taagaacaat aggcctagcg gcatccccga gcggtttagc      180

ggctctaata gcggcaacac cgctaccctg actattagcg gcactcaggc cgaggacgag      240

gccgactact actgtcagtc ctacgacggc cagaagtcac tggtctttgg cggcggaact      300

aagctgaccg tgctg                                                       315


<210>  191
<211>  10
<212>  PRT
<213>  Homo Sapien

<400>  191

Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val 
1               5                   10  


<210>  192
<211>  119
<212>  PRT
<213>  Homo Sapien

<400>  192

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  193
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  193

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  194
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  194
gacatcgagc tgactcagcc ccctagcgtg tcagtggctc ctggccagac cgctagaatt       60

agctgtagcg gcgatagcct gcgtaacaag gtctactggt atcagcagaa gcccggccag      120

gcccctgtgc tggtcatcta taagaacaat aggcctagcg gcatccccga gcggtttagc      180

ggctctaata gcggcaacac cgctaccctg actattagcg gcactcaggc cgaggacgag      240

gccgactact actgtcagtc ctacgacggc cagaagtcac tggtctttgg cggcggaact      300

aagctgaccg tgctgggaca gcctaaggct gcccccagcg tgaccctgtt cccccccagc      360

agcgaggagc tgcaggccaa caaggccacc ctggtgtgcc tgatcagcga cttctaccca      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagacc      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca caggtcctac agctgccagg tgacccacga gggcagcacc      600

gtggaaaaga ccgtggcccc aaccgagtgc agc                                   633


<210>  195
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  195

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  196
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  196
caggtgcagc tggtggaatc aggcggagga ctggtccagc ctggcggatc acttagactg       60

agctgtgccg ctagtggctt cacctttagc gactatgtga ttaactgggt ccgacaggcc      120

cctggcaagg gactggaatg ggtgtcaggc attagttgga gcggcgtgaa cactcactac      180

gccgatagcg tgaagggccg gttcactatt agccgggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagactgggc      300

gctaccgcta acaacatccg ctataagttc atggacgtgt ggggccaggg caccctggtc      360

acagtgtctt cagctagcac taagggcccc tcagtgttcc ccctggcccc tagctctaag      420

tctactagcg gtggcaccgc cgctctgggc tgcctggtca aggactactt ccccgagccc      480

gtgaccgtgt cttggaatag cggcgctctg actagcggag tgcacacctt ccccgccgtg      540

ctgcagtcta gcggcctgta tagcctgtct agcgtcgtga ccgtgcctag ctctagcctg      600

ggcactcaga cctatatctg taacgtgaac cacaagccta gtaacactaa ggtggacaag      660

cgggtggaac ctaagtcttg cgataagact cacacctgtc ccccctgccc tgccccagaa      720

gctgctggcg gacctagcgt gttcctgttc ccacctaagc ctaaagacac cctgatgatt      780

agtaggaccc ccgaagtgac ctgcgtggtg gtggacgtca gccacgagga ccctgaagtg      840

aagttcaatt ggtatgtgga cggcgtggaa gtgcacaacg ctaagactaa gcctagagag      900

gaacagtata actccaccta tagggtggtg tcagtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aagagtataa gtgtaaagtc tctaacaagg ccctgcctgc ccctatcgaa     1020

aagactatct ctaaggctaa gggccagcct agagaacccc aggtctacac cctgccccct     1080

agtagagaag agatgactaa gaatcaggtg tccctgacct gtctggtcaa gggcttctac     1140

cctagcgata tcgccgtgga gtgggagtct aacggccagc ccgagaacaa ctataagact     1200

accccccctg tgctggatag cgacggctct ttcttcctgt actctaaact gaccgtggac     1260

aagtctaggt ggcagcaggg caacgtgttc agctgtagcg tgatgcacga ggccctgcac     1320

aatcactaca ctcagaagtc actgagcctg agtcccggca agggcggctc aggcggtagc     1380

gatatcgtgc tgactcagtc acccgctacc ctgagtctga gccctggcga gcgggctaca     1440

ctgagctgta gagctagtca gtttatcggc tcacgctacc tggcctggta tcagcagaag     1500

cccggccagg cccctagact gctgatctac ggcgctagta atagagctac cggcgtgccc     1560

gctaggttta gcggctcagg atcaggcacc gactttaccc tgactattag tagcctggaa     1620

cccgaggact tcgctaccta ctactgtcag cagtactacg actaccctca gaccttcggc     1680

cagggaacta aggtcgagat taagggcggt ggcggtagcg gcggaggcgg atcaggtggt     1740

ggtggtagtg gcggcggagg tagtcaggtc cagctgaaag agtcaggccc tgccctggtc     1800

aagcctactc agaccctgac cctgacctgc acttttagcg gctttagcct gagtaataga     1860

ggcggcggag tgggctggat tagacagcct ccaggcaaag ccctggagtg gctggcctgg     1920

atcgactggg acgacgataa gtcctactcc actagcctga aaactaggct gacaatcagc     1980

aaggacacta gtaaaaacca ggtggtgctg actatgacta atatggaccc cgtggacacc     2040

gctacctatt attgcgctag aatgcacctc ccactggtgt tcgatagctg gggtcaggga     2100

actctggtca cagtcagtag c                                               2121


<210>  197
<211>  105
<212>  PRT
<213>  Homo Sapien

<400>  197

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  198
<211>  315
<212>  DNA
<213>  Homo Sapien

<400>  198
tcttacgagc tgacccagcc cccttccgtg tctgtggctc ctggccagac cgccagaatc       60

tcttgctccg gcgactccct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gcccctgtgc tggtcatcta caagaacaac cggccctccg gcatccccga gagattctct      180

ggctccaact ccggcaacac cgccaccctg acaatctctg gcacacaggc cgaggacgag      240

gccgactact actgccagtc ctacgacggc cagaaatcac tggtgttcgg cggaggcacc      300

aagctgacag tgctg                                                       315


<210>  199
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  199

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  200
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  200
tcttacgagc tgacccagcc cccttccgtg tctgtggctc ctggccagac cgccagaatc       60

tcttgctccg gcgactccct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gcccctgtgc tggtcatcta caagaacaac cggccctccg gcatccccga gagattctct      180

ggctccaact ccggcaacac cgccaccctg acaatctctg gcacacaggc cgaggacgag      240

gccgactact actgccagtc ctacgacggc cagaaatcac tggtgttcgg cggaggcacc      300

aagctgacag tgctgggaca gcctaaggct gcccccagcg tgaccctgtt cccccccagc      360

agcgaggagc tgcaggccaa caaggccacc ctggtgtgcc tgatcagcga cttctaccca      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagacc      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca caggtcctac agctgccagg tgacccacga gggcagcacc      600

gtggaaaaga ccgtggcccc aaccgagtgc agc                                   633


<210>  201
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  201

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  202
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  202
caggtgcagc tggtggaatc aggcggagga ctggtccagc ctggcggatc acttagactg       60

agctgtgccg ctagtggctt cacctttagc gactatgtga ttaactgggt ccgacaggcc      120

cctggcaagg gactggaatg ggtgtcaggc attagttgga gcggcgtgaa cactcactac      180

gccgatagcg tgaagggccg gttcactatt agccgggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagactgggc      300

gctaccgcta acaacatccg ctataagttc atggacgtgt ggggccaggg caccctggtc      360

acagtgtctt cagctagcac taagggcccc tcagtgttcc ccctggcccc tagctctaag      420

tctactagcg gtggcaccgc cgctctgggc tgcctggtca aggactactt ccccgagccc      480

gtgaccgtgt cttggaatag cggcgctctg actagcggag tgcacacctt ccccgccgtg      540

ctgcagtcta gcggcctgta tagcctgtct agcgtcgtga ccgtgcctag ctctagcctg      600

ggcactcaga cctatatctg taacgtgaac cacaagccta gtaacactaa ggtggacaag      660

cgggtggaac ctaagtcttg cgataagact cacacctgtc ccccctgccc tgccccagaa      720

gctgctggcg gacctagcgt gttcctgttc ccacctaagc ctaaagacac cctgatgatt      780

agtaggaccc ccgaagtgac ctgcgtggtg gtggacgtca gccacgagga ccctgaagtg      840

aagttcaatt ggtatgtgga cggcgtggaa gtgcacaacg ctaagactaa gcctagagag      900

gaacagtata actccaccta tagggtggtg tcagtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aagagtataa gtgtaaagtc tctaacaagg ccctgcctgc ccctatcgaa     1020

aagactatct ctaaggctaa gggccagcct agagaacccc aggtctacac cctgccccct     1080

agtagagaag agatgactaa gaatcaggtg tccctgacct gtctggtcaa gggcttctac     1140

cctagcgata tcgccgtgga gtgggagtct aacggccagc ccgagaacaa ctataagact     1200

accccccctg tgctggatag cgacggctct ttcttcctgt actctaaact gaccgtggac     1260

aagtctaggt ggcagcaggg caacgtgttc agctgtagcg tgatgcacga ggccctgcac     1320

aatcactaca ctcagaagtc actgagcctg agtcccggca agggcggctc aggcggtagc     1380

gatatcgtgc tgactcagtc acccgctacc ctgagtctga gccctggcga gcgggctaca     1440

ctgagctgta gagctagtca gtttatcggc tcacgctacc tggcctggta tcagcagaag     1500

cccggccagg cccctagact gctgatctac ggcgctagta atagagctac cggcgtgccc     1560

gctaggttta gcggctcagg atcaggcacc gactttaccc tgactattag tagcctggaa     1620

cccgaggact tcgctaccta ctactgtcag cagtactacg actaccctca gaccttcggc     1680

cagggaacta aggtcgagat taagggcggt ggcggtagcg gcggaggcgg atcaggtggt     1740

ggtggtagtg gcggcggagg tagtcaggtc cagctgaaag agtcaggccc tgccctggtc     1800

aagcctactc agaccctgac cctgacctgc acttttagcg gctttagcct gagtaataga     1860

ggcggcggag tgggctggat tagacagcct ccaggcaaag ccctggagtg gctggcctgg     1920

atcgactggg acgacgataa gtcctactcc actagcctga aaactaggct gacaatcagc     1980

aaggacacta gtaaaaacca ggtggtgctg actatgacta atatggaccc cgtggacacc     2040

gctacctatt attgcgctag aatgcacctc ccactggtgt tcgatagctg gggtcaggga     2100

actctggtca cagtcagtag c                                               2121


<210>  203
<211>  105
<212>  PRT
<213>  Homo Sapien

<400>  203

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105 


<210>  204
<211>  315
<212>  DNA
<213>  Homo Sapien

<400>  204
agctacgagc tgactcagcc cctgagcgtg tcagtggctc tgggccagac cgctagaatc       60

acctgtagcg gcgatagcct gagaaacaag gtctactggt atcagcagaa gcccggccag      120

gcccctgtgc tggtcatcta taagaacaat aggcctagcg gcatccccga gcggtttagc      180

ggctctaata gcggcaacac cgctaccctg actattagta gggctcaggc cggcgacgag      240

gccgactact actgtcagtc ctacgacggc cagaagtcac tggtctttgg cggcggaact      300

aagctgaccg tgctg                                                       315


<210>  205
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  205

Ser Tyr Glu Leu Thr Gln Pro Leu Ser Val Ser Val Ala Leu Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Arg Ala Gln Ala Gly Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  206
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  206
agctacgagc tgactcagcc cctgagcgtg tcagtggctc tgggccagac cgctagaatc       60

acctgtagcg gcgatagcct gagaaacaag gtctactggt atcagcagaa gcccggccag      120

gcccctgtgc tggtcatcta taagaacaat aggcctagcg gcatccccga gcggtttagc      180

ggctctaata gcggcaacac cgctaccctg actattagta gggctcaggc cggcgacgag      240

gccgactact actgtcagtc ctacgacggc cagaagtcac tggtctttgg cggcggaact      300

aagctgaccg tgctgggaca gcctaaggct gcccccagcg tgaccctgtt cccccccagc      360

agcgaggagc tgcaggccaa caaggccacc ctggtgtgcc tgatcagcga cttctaccca      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagacc      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca caggtcctac agctgccagg tgacccacga gggcagcacc      600

gtggaaaaga ccgtggcccc aaccgagtgc agc                                   633


<210>  207
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  207

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  208
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  208
gaggtgcagc tgctggaatc aggcggagga ctggtgcagc ctggcggatc actgagactg       60

agctgtgccg ctagtggctt cacctttagc gactatgtga ttaactgggt ccgacaggcc      120

cctggcaagg gactggaatg ggtgtcaggc attagttgga gcggcgtgaa cactcactac      180

gccgatagcg tgaagggccg gttcactatt agccgggata actctaagaa caccctgtac      240

ctgcagatga atagcctgag agccgaggac accgccgtct actactgcgc tagactgggc      300

gctaccgcta acaacatccg ctataagttc atggacgtgt ggggccaggg caccctggtc      360

acagtgtctt cagctagcac taagggcccc tcagtgttcc ccctggcccc tagctctaag      420

tctactagcg gtggcaccgc cgctctgggc tgcctggtca aggactactt ccccgagccc      480

gtgaccgtgt cttggaatag cggcgctctg actagcggag tgcacacctt ccccgccgtg      540

ctgcagtcta gcggcctgta tagcctgtct agcgtcgtga ccgtgcctag ctctagcctg      600

ggcactcaga cctatatctg taacgtgaac cacaagccta gtaacactaa ggtggacaag      660

cgggtggaac ctaagtcttg cgataagact cacacctgtc ccccctgccc tgccccagaa      720

gctgctggcg gacctagcgt gttcctgttc ccacctaagc ctaaagacac cctgatgatt      780

agtaggaccc ccgaagtgac ctgcgtggtg gtggacgtca gccacgagga ccctgaagtg      840

aagttcaatt ggtatgtgga cggcgtggaa gtgcacaacg ctaagactaa gcctagagag      900

gaacagtata actccaccta tagggtggtg tcagtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aagagtataa gtgtaaagtc tctaacaagg ccctgcctgc ccctatcgaa     1020

aagactatct ctaaggctaa gggccagcct agagaacccc aggtctacac cctgccccct     1080

agtagagaag agatgactaa gaatcaggtg tccctgacct gtctggtcaa gggcttctac     1140

cctagcgata tcgccgtgga gtgggagtct aacggccagc ccgagaacaa ctataagact     1200

accccccctg tgctggatag cgacggctct ttcttcctgt actctaaact gaccgtggac     1260

aagtctaggt ggcagcaggg caacgtgttc agctgtagcg tgatgcacga ggccctgcac     1320

aatcactaca ctcagaagtc actgagcctg agtcccggca agggcggctc aggcggtagc     1380

gatatcgtgc tgactcagtc acccgctacc ctgagtctga gccctggcga gcgggctaca     1440

ctgagctgta gagctagtca gtttatcggc tcacgctacc tggcctggta tcagcagaag     1500

cccggccagg cccctagact gctgatctac ggcgctagta atagagctac cggcgtgccc     1560

gctaggttta gcggctcagg atcaggcacc gactttaccc tgactattag tagcctggaa     1620

cccgaggact tcgctaccta ctactgtcag cagtactacg actaccctca gaccttcggc     1680

cagggaacta aggtcgagat taagggcggt ggcggtagcg gcggaggcgg atcaggtggt     1740

ggtggtagtg gcggcggagg tagtcaggtc cagctgaaag agtcaggccc tgccctggtc     1800

aagcctactc agaccctgac cctgacctgc acttttagcg gctttagcct gagtaataga     1860

ggcggcggag tgggctggat tagacagcct ccaggcaaag ccctggagtg gctggcctgg     1920

atcgactggg acgacgataa gtcctactcc actagcctga aaactaggct gacaatcagc     1980

aaggacacta gtaaaaacca ggtggtgctg actatgacta atatggaccc cgtggacacc     2040

gctacctatt attgcgctag aatgcacctc ccactggtgt tcgatagctg gggtcaggga     2100

actctggtca cagtcagtag c                                               2121


<210>  209
<211>  585
<212>  PRT
<213>  Homo Sapien

<400>  209

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Cys Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  210
<211>  585
<212>  PRT
<213>  Homo Sapien

<400>  210

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
            20                  25                  30          


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
        35                  40                  45              


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
    50                  55                  60                  


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
65                  70                  75                  80  


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
                85                  90                  95      


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
            100                 105                 110         


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
        115                 120                 125             


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
    130                 135                 140                 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
145                 150                 155                 160 


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
                165                 170                 175     


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
            180                 185                 190         


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
        195                 200                 205             


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
    210                 215                 220                 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
225                 230                 235                 240 


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
                245                 250                 255     


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
            260                 265                 270         


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
        275                 280                 285             


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
    290                 295                 300                 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
305                 310                 315                 320 


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
                325                 330                 335     


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
            340                 345                 350         


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
        355                 360                 365             


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
    370                 375                 380                 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
385                 390                 395                 400 


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
                405                 410                 415     


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
            420                 425                 430         


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
        435                 440                 445             


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
    450                 455                 460                 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
465                 470                 475                 480 


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
                485                 490                 495     


Tyr Val Pro Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp 
            500                 505                 510         


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
        515                 520                 525             


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
    530                 535                 540                 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
545                 550                 555                 560 


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
                565                 570                 575     


Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            580                 585 


<210>  211
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  211

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  212
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  212
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgattctct tcgtaataag gtttattggt accagcagaa acccgggcag      120

gcgccagttc ttgtgattta taagaataat cgtccctcag gcatcccgga acgctttagc      180

ggatccaaca gcggcaacac cgcgaccctg accattagcg gcactcaggc ggaagacgaa      240

gcggattatt attgccagtc ttatgatggt cagaagtctc ttgtgtttgg cggcggcacg      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  213
<211>  822
<212>  PRT
<213>  Homo Sapien

<400>  213

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Glu Ala His Lys Ser Glu Ile Ala 
225                 230                 235                 240 


His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu 
                245                 250                 255     


Ile Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala 
            260                 265                 270         


Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp 
        275                 280                 285             


Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
    290                 295                 300                 


Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala 
305                 310                 315                 320 


Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
                325                 330                 335     


His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala 
            340                 345                 350         


Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly 
        355                 360                 365             


His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
    370                 375                 380                 


Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys 
385                 390                 395                 400 


Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly 
                405                 410                 415     


Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys 
            420                 425                 430         


Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
        435                 440                 445             


Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr 
    450                 455                 460                 


Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly 
465                 470                 475                 480 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met 
                485                 490                 495     


Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp 
            500                 505                 510         


Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp 
        515                 520                 525             


Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp 
    530                 535                 540                 


Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
545                 550                 555                 560 


Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser 
                565                 570                 575     


Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys 
            580                 585                 590         


Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu 
        595                 600                 605             


Phe Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys 
    610                 615                 620                 


Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu 
625                 630                 635                 640 


Val Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val 
                645                 650                 655     


Glu Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu 
            660                 665                 670         


Pro Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile 
        675                 680                 685             


Leu Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His 
    690                 695                 700                 


Val Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe 
705                 710                 715                 720 


Ser Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala 
                725                 730                 735     


Glu Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu 
            740                 745                 750         


Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys 
        755                 760                 765             


Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala 
    770                 775                 780                 


Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe 
785                 790                 795                 800 


Ser Thr Glu Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala 
                805                 810                 815     


His His His His His His 
            820         


<210>  214
<211>  2466
<212>  DNA
<213>  Homo Sapien

<400>  214
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gattatgtta ttaattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atttcttggt ctggtgttaa tactcattat      180

gctgattctg ttaagggtcg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtcttggt      300

gctactgcta ataatattcg ttataagttt atggatgttt ggggccaagg caccctggtg      360

acggttagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcacctctg gcggcactgc tgccctgggc tgcctggtca aggactactt ccccgagccc      480

gtgacagtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtca cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtcgacaag      660

aaggtggagc ccaagagctg cgacaagacc cacaccgagg cccacaagag cgagatcgcc      720

caccggtaca acgacctggg agagcagcat ttcaagggac tggtgctgat cgccttcagc      780

cagtacctgc agaagtgcag ctacgacgag cacgccaagc tggtgcagga agtgaccgac      840

ttcgccaaga cctgcgtggc cgacgagagc gccgccaact gcgacaagag cctgcacacc      900

ctgttcggcg acaagctgtg cgccatcccc aacctgcggg agaactacgg cgagctggcc      960

gactgctgca ccaagcagga acccgagcgg aacgagtgct tcctgcagca caaggacgac     1020

aaccccagcc tgcccccctt cgagaggcct gaggccgagg ccatgtgcac cagcttcaaa     1080

gagaacccca ccaccttcat gggccactac ctgcacgagg tggccaggcg gcacccctac     1140

ttctacgccc ccgagctgct gtactacgcc gagcagtaca acgagatcct gacccagtgc     1200

tgcgccgagg ccgacaaaga gagctgcctg acccccaagc tggacggcgt gaaagaaaag     1260

gccctggtgt ccagcgtgcg gcagcggatg aagtgcagca gcatgcagaa gttcggcgag     1320

cgggccttca aggcctgggc cgtggcccgg ctgtcccaga ccttccccaa cgccgatttc     1380

gccgagatca ccaagctggc caccgacctg accaaggtga acaaagagtg ctgtcacggc     1440

gacctgctgg aatgcgccga cgaccgggcc gagctggcca agtacatgtg cgagaaccag     1500

gccaccatca gctccaaact gcagacctgc tgtgataagc ccctgctgaa gaaggcccac     1560

tgcctgagcg aggtggagca cgacaccatg cccgccgacc tgcccgccat tgccgccgac     1620

ttcgtggagg accaggaagt gtgcaagaat tacgccgagg ccaaggacgt gttcctgggc     1680

accttcctgt acgagtacag cagacggcac cccgactaca gcgtgagcct gctgctgagg     1740

ctggccaaga agtacgaggc caccctggaa aagtgttgcg ccgaagccaa cccccctgcc     1800

tgctacggca ccgtgctggc cgagttccag cccctggtgg aggaacccaa gaacctggtg     1860

aaaaccaact gcgatctgta cgagaagctg ggcgagtacg gcttccagaa cgccatcctg     1920

gtccggtaca cccagaaagc cccccaggtg tccaccccca cactggtgga ggccgccagg     1980

aacctgggca gagtcggcac caagtgctgc accctgcccg aggatcagag gctgccctgt     2040

gtcgaggact acctgagcgc catcctgaac agagtgtgcc tgctgcacga gaaaaccccc     2100

gtgagcgagc acgtgaccaa gtgttgcagc ggcagcctgg tggagcggag gccctgcttc     2160

agcgccctga ccgtggacga gacatacgtg cccaaagagt tcaaggccga gacattcacc     2220

ttccacagcg acatctgtac cctgcctgag aaagagaagc agatcaagaa gcagaccgcc     2280

ctggccgaac tggtgaagca caagcccaag gccaccgccg agcagctgaa aaccgtgatg     2340

gacgacttcg cccagttcct ggacacctgc tgcaaggccg ccgacaagga cacctgtttc     2400

agcaccgagg gccccaacct ggtgacccgg tgcaaggacg ccctggccca ccatcatcac     2460

catcac                                                                2466


<210>  215
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  215

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  216
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  216
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  217
<211>  822
<212>  PRT
<213>  Homo Sapien

<400>  217

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Glu Ala His Lys Ser Glu Ile Ala 
225                 230                 235                 240 


His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu 
                245                 250                 255     


Ile Ala Phe Ser Gln Tyr Leu Gln Lys Ser Ser Tyr Asp Glu His Ala 
            260                 265                 270         


Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp 
        275                 280                 285             


Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
    290                 295                 300                 


Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala 
305                 310                 315                 320 


Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
                325                 330                 335     


His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala 
            340                 345                 350         


Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly 
        355                 360                 365             


His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
    370                 375                 380                 


Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys 
385                 390                 395                 400 


Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly 
                405                 410                 415     


Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys 
            420                 425                 430         


Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
        435                 440                 445             


Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr 
    450                 455                 460                 


Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly 
465                 470                 475                 480 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met 
                485                 490                 495     


Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp 
            500                 505                 510         


Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp 
        515                 520                 525             


Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp 
    530                 535                 540                 


Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
545                 550                 555                 560 


Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser 
                565                 570                 575     


Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys 
            580                 585                 590         


Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu 
        595                 600                 605             


Phe Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys 
    610                 615                 620                 


Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu 
625                 630                 635                 640 


Val Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val 
                645                 650                 655     


Glu Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu 
            660                 665                 670         


Pro Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile 
        675                 680                 685             


Leu Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His 
    690                 695                 700                 


Val Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe 
705                 710                 715                 720 


Ser Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala 
                725                 730                 735     


Glu Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu 
            740                 745                 750         


Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys 
        755                 760                 765             


Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala 
    770                 775                 780                 


Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe 
785                 790                 795                 800 


Ser Thr Glu Gly Pro Asn Leu Val Thr Arg Ser Lys Asp Ala Leu Ala 
                805                 810                 815     


His His His His His His 
            820         


<210>  218
<211>  2466
<212>  DNA
<213>  Homo Sapien

<400>  218
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcacctctg gcggcactgc tgccctgggc tgcctggtca aggactactt ccccgagccc      480

gtgacagtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtca cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtcgacaag      660

aaggtggagc ccaagagctg cgacaagacc cacaccgagg cccacaagag cgagatcgcc      720

caccggtaca acgacctggg agagcagcat ttcaagggac tggtgctgat cgccttcagc      780

cagtacctgc agaagtccag ctacgacgag cacgccaagc tggtgcagga agtgaccgac      840

ttcgccaaga cctgcgtggc cgacgagagc gccgccaact gcgacaagag cctgcacacc      900

ctgttcggcg acaagctgtg cgccatcccc aacctgcggg agaactacgg cgagctggcc      960

gactgctgca ccaagcagga acccgagcgg aacgagtgct tcctgcagca caaggacgac     1020

aaccccagcc tgcccccctt cgagaggcct gaggccgagg ccatgtgcac cagcttcaaa     1080

gagaacccca ccaccttcat gggccactac ctgcacgagg tggccaggcg gcacccctac     1140

ttctacgccc ccgagctgct gtactacgcc gagcagtaca acgagatcct gacccagtgc     1200

tgcgccgagg ccgacaaaga gagctgcctg acccccaagc tggacggcgt gaaagaaaag     1260

gccctggtgt ccagcgtgcg gcagcggatg aagtgcagca gcatgcagaa gttcggcgag     1320

cgggccttca aggcctgggc cgtggcccgg ctgtcccaga ccttccccaa cgccgatttc     1380

gccgagatca ccaagctggc caccgacctg accaaggtga acaaagagtg ctgtcacggc     1440

gacctgctgg aatgcgccga cgaccgggcc gagctggcca agtacatgtg cgagaaccag     1500

gccaccatca gctccaaact gcagacctgc tgtgataagc ccctgctgaa gaaggcccac     1560

tgcctgagcg aggtggagca cgacaccatg cccgccgacc tgcccgccat tgccgccgac     1620

ttcgtggagg accaggaagt gtgcaagaat tacgccgagg ccaaggacgt gttcctgggc     1680

accttcctgt acgagtacag cagacggcac cccgactaca gcgtgagcct gctgctgagg     1740

ctggccaaga agtacgaggc caccctggaa aagtgttgcg ccgaagccaa cccccctgcc     1800

tgctacggca ccgtgctggc cgagttccag cccctggtgg aggaacccaa gaacctggtg     1860

aaaaccaact gcgatctgta cgagaagctg ggcgagtacg gcttccagaa cgccatcctg     1920

gtccggtaca cccagaaagc cccccaggtg tccaccccca cactggtgga ggccgccagg     1980

aacctgggca gagtcggcac caagtgctgc accctgcccg aggatcagag gctgccctgt     2040

gtcgaggact acctgagcgc catcctgaac agagtgtgcc tgctgcacga gaaaaccccc     2100

gtgagcgagc acgtgaccaa gtgttgcagc ggcagcctgg tggagcggag gccctgcttc     2160

agcgccctga ccgtggacga gacatacgtg cccaaagagt tcaaggccga gacattcacc     2220

ttccacagcg acatctgtac cctgcctgag aaagagaagc agatcaagaa gcagaccgcc     2280

ctggccgaac tggtgaagca caagcccaag gccaccgccg agcagctgaa aaccgtgatg     2340

gacgacttcg cccagttcct ggacacctgc tgcaaggccg ccgacaagga cacctgtttc     2400

agcaccgagg gccccaacct ggtgacccgg tccaaggacg ccctggccca ccatcatcac     2460

catcac                                                                2466


<210>  219
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  219

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  220
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  220
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  221
<211>  817
<212>  PRT
<213>  Homo Sapien

<400>  221

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Asp Ala His Lys Ser Glu Val Ala 
225                 230                 235                 240 


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
                245                 250                 255     


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 
            260                 265                 270         


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
        275                 280                 285             


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
    290                 295                 300                 


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
305                 310                 315                 320 


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
                325                 330                 335     


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
            340                 345                 350         


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
        355                 360                 365             


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
    370                 375                 380                 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
385                 390                 395                 400 


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
                405                 410                 415     


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
            420                 425                 430         


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
        435                 440                 445             


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
    450                 455                 460                 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
465                 470                 475                 480 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
                485                 490                 495     


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
            500                 505                 510         


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
        515                 520                 525             


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
    530                 535                 540                 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
545                 550                 555                 560 


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
                565                 570                 575     


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
            580                 585                 590         


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
        595                 600                 605             


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
    610                 615                 620                 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
625                 630                 635                 640 


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
                645                 650                 655     


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
            660                 665                 670         


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
        675                 680                 685             


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
    690                 695                 700                 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
705                 710                 715                 720 


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
                725                 730                 735     


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
            740                 745                 750         


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
        755                 760                 765             


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
    770                 775                 780                 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
785                 790                 795                 800 


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
                805                 810                 815     


Leu 
    


<210>  222
<211>  2451
<212>  DNA
<213>  Homo Sapien

<400>  222
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc ctccagcaag      420

tccacaagcg gtggcacagc agctctgggt tgcctggtga aggactactt ccccgagccc      480

gtgacagtgt cctggaactc tggcgccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga cagtccccag cagcagcttg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

aaggtggagc ccaagagctg cgacaagacc cacaccgacg cccacaagag cgaggtggcc      720

caccggttca aggacctggg cgaggaaaac ttcaaggccc tggtgctgat cgccttcgcc      780

cagtacctgc agcagagccc cttcgaagat cacgtaaagt tagtcaacga ggttacggaa      840

ttcgcaaaga catgcgttgc tgacgaatcc gctgagaatt gtgacaagag tttgcacact      900

ttattcggag ataagttgtg tactgtagct actttgagag agacttacgg tgaaatggct      960

gactgctgtg caaaacagga accagaacgt aacgaatgtt tccttcagca taaggatgat     1020

aaccctaacc ttccaaggct tgttaggcca gaagtcgacg tgatgtgcac cgccttccat     1080

gataatgaag agacttttct taaaaagtac ctatacgaga ttgcaaggcg tcatccatat     1140

ttttacgccc cagagctgtt gtttttcgca aagagataca aagctgcatt tactgagtgt     1200

tgccaagctg ccgacaaggc cgcttgtttg ctaccaaagt tggacgaatt gagagacgag     1260

ggtaaggcat catctgccaa gcagagatta aaatgtgcat ctttgcaaaa atttggagag     1320

agagctttta aggcatgggc tgttgcccga ctaagccaaa gattcccaaa agccgaattt     1380

gctgaagtat ccaagctggt gactgatttg actaaagtac atacagaatg ttgccatggc     1440

gaccttttag aatgtgctga tgacagagca gatttggcta agtatatctg cgaaaatcaa     1500

gattcaatca gctctaagct gaaggaatgt tgcgagaaac cactgttaga aaaatcgcat     1560

tgtattgctg aagttgaaaa tgatgagatg cctgctgact tgccttctct tgccgctgat     1620

tttgttgagt cgaaggatgt ctgtaagaat tatgctgaag ctaaagacgt tttcctgggt     1680

atgttcttat atgagtacgc aagacgtcac ccagattact ctgtggttct gctactgaga     1740

ttggctaaaa catacgagac aacgctggag aagtgctgtg ctgccgctga ccctcatgag     1800

tgctatgcaa aggtttttga tgaattcaaa ccattggttg aagagcctca aaacttgata     1860

aagcagaact gtgagctgtt tgagcaattg ggtgagtata agttccaaaa tgccctgttg     1920

gtgagatata caaaaaaggt accccaagtt tcaacgccca ctttagttga agtgtccaga     1980

aatcttggta aagtgggtag caaatgttgc aagcatccag aagccaagcg aatgccctgt     2040

gctgaggatt atctgtccgt cgtgttgaac caattgtgcg tattacacga aaaaacccca     2100

gtctctgata gagtcaccaa atgttgcact gagtcactag ttaatagaag gccttgtttt     2160

tccgctttgg aagttgatga aacctacgtg cctaaggaat ttaacgctga gacctttacc     2220

tttcacgctg acatttgtac tttgagtgaa aaagagcgtc aaatcaaaaa gcaaaccgct     2280

cttgttgaat tggtgaaaca caagcctaag gctacgaagg agcagcttaa agccgtcatg     2340

gacgatttcg ccgcatttgt tgaaaaatgc tgtaaagctg atgacaagga aacatgtttc     2400

gctgaagagg gaaagaaatt ggttgcggcc agtcaggccg cacttggttt g              2451


<210>  223
<211>  213
<212>  PRT
<213>  Homo Sapien

<400>  223

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  224
<211>  639
<212>  DNA
<213>  Homo Sapien

<400>  224
gacatcgagc tgacccagcc ccccagcgtg tctgtggccc ctggccagac cgcccggatc       60

agctgcagcg gcgacaacat cggcagcaaa tacgtgcact ggtatcagca gaagcccggc      120

caggcccccg tgctggtcat ctacggcgac agcaaccggc ccagcggcat ccccgagcgg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccgag      240

gacgaggccg actactactg cacccggacc agcaccccca tctccggcgt gtttggcggc      300

ggaacaaagc tgaccgtgct gggccagccc aaagccgccc ctagcgtgac cctgttcccc      360

cccagcagcg aggaactgca ggccaacaag gccaccctgg tctgcctgat cagcgacttc      420

taccctggcg ccgtgaccgt ggcctggaag gccgacagca gccccgtgaa ggccggcgtg      480

gagacaacca cccccagcaa gcagagcaac aacaagtacg ccgccagcag ctacctgagc      540

ctgacccccg agcagtggaa gagccacaga agctacagct gccaggtcac ccacgagggc      600

agcaccgtgg agaaaaccgt ggcccccacc gagtgcagc                             639


<210>  225
<211>  817
<212>  PRT
<213>  Homo Sapien

<400>  225

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp 
225                 230                 235                 240 


Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln 
                245                 250                 255     


Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu 
            260                 265                 270         


Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn 
        275                 280                 285             


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile 
    290                 295                 300                 


Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys 
305                 310                 315                 320 


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
                325                 330                 335     


Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr 
            340                 345                 350         


Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu 
        355                 360                 365             


Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr 
    370                 375                 380                 


Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp 
385                 390                 395                 400 


Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala 
                405                 410                 415     


Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys 
            420                 425                 430         


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
        435                 440                 445             


Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp 
    450                 455                 460                 


Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
465                 470                 475                 480 


Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala 
                485                 490                 495     


Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys 
            500                 505                 510         


Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp 
        515                 520                 525             


Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys 
    530                 535                 540                 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu 
545                 550                 555                 560 


Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu 
                565                 570                 575     


Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn 
            580                 585                 590         


Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val 
        595                 600                 605             


Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys 
    610                 615                 620                 


Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln 
625                 630                 635                 640 


Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn 
                645                 650                 655     


Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg 
            660                 665                 670         


Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys 
        675                 680                 685             


Leu Leu His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys 
    690                 695                 700                 


Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val 
705                 710                 715                 720 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe 
                725                 730                 735     


His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys 
            740                 745                 750         


Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala 
        755                 760                 765             


Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr 
    770                 775                 780                 


Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro 
785                 790                 795                 800 


Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala His His His His His 
                805                 810                 815     


His 
    


<210>  226
<211>  2451
<212>  DNA
<213>  Homo Sapien

<400>  226
caggtgcagc tggtcgagtc tggcggggga ctggtccagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gtgaacggca tgcactgggt ccgccaggca      120

ccaggcaagg gcctggaatg ggtgtccgtg atcgacggca tgggccacac ctactacgcc      180

gacagcgtga agggccggtt caccatcagc cgggacaaca gcaagaacac cctgtacctg      240

cagatgaaca gcctgcgggc cgaggacacc gccgtgtact actgcgccag atacgactac      300

atcaagtacg gcgccttcga cccctggggc cagggcacac tggtcaccgt gtccagcgct      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac ctctggcggc      420

actgctgccc tgggctgcct ggtcaaggac tacttccccg agcccgtgac agtgtcctgg      480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgagcagcgt ggtcacagtg cccagcagca gcctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagaaggt ggagcccaag      660

agctgcgaca agacccacac cgaggcccac aagagcgaga tcgcccaccg gtacaacgac      720

ctgggagagc agcatttcaa gggactggtg ctgatcgcct tcagccagta cctgcagaag      780

tgcagctacg acgagcacgc caagctggtg caggaagtga ccgacttcgc caagacctgc      840

gtggccgacg agagcgccgc caactgcgac aagagcctgc acaccctgtt cggcgacaag      900

ctgtgcgcca tccccaacct gcgggagaac tacggcgagc tggccgactg ctgcaccaag      960

caggaacccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc cagcctgccc     1020

cccttcgaga ggcctgaggc cgaggccatg tgcaccagct tcaaagagaa ccccaccacc     1080

ttcatgggcc actacctgca cgaggtggcc aggcggcacc cctacttcta cgcccccgag     1140

ctgctgtact acgccgagca gtacaacgag atcctgaccc agtgctgcgc cgaggccgac     1200

aaagagagct gcctgacccc caagctggac ggcgtgaaag aaaaggccct ggtgtccagc     1260

gtgcggcagc ggatgaagtg cagcagcatg cagaagttcg gcgagcgggc cttcaaggcc     1320

tgggccgtgg cccggctgtc ccagaccttc cccaacgccg atttcgccga gatcaccaag     1380

ctggccaccg acctgaccaa ggtgaacaaa gagtgctgtc acggcgacct gctggaatgc     1440

gccgacgacc gggccgagct ggccaagtac atgtgcgaga accaggccac catcagctcc     1500

aaactgcaga cctgctgtga taagcccctg ctgaagaagg cccactgcct gagcgaggtg     1560

gagcacgaca ccatgcccgc cgacctgccc gccattgccg ccgacttcgt ggaggaccag     1620

gaagtgtgca agaattacgc cgaggccaag gacgtgttcc tgggcacctt cctgtacgag     1680

tacagcagac ggcaccccga ctacagcgtg agcctgctgc tgaggctggc caagaagtac     1740

gaggccaccc tggaaaagtg ttgcgccgaa gccaaccccc ctgcctgcta cggcaccgtg     1800

ctggccgagt tccagcccct ggtggaggaa cccaagaacc tggtgaaaac caactgcgat     1860

ctgtacgaga agctgggcga gtacggcttc cagaacgcca tcctggtccg gtacacccag     1920

aaagcccccc aggtgtccac ccccacactg gtggaggccg ccaggaacct gggcagagtc     1980

ggcaccaagt gctgcaccct gcccgaggat cagaggctgc cctgtgtcga ggactacctg     2040

agcgccatcc tgaacagagt gtgcctgctg cacgagaaaa cccccgtgag cgagcacgtg     2100

accaagtgtt gcagcggcag cctggtggag cggaggccct gcttcagcgc cctgaccgtg     2160

gacgagacat acgtgcccaa agagttcaag gccgagacat tcaccttcca cagcgacatc     2220

tgtaccctgc ctgagaaaga gaagcagatc aagaagcaga ccgccctggc cgaactggtg     2280

aagcacaagc ccaaggccac cgccgagcag ctgaaaaccg tgatggacga cttcgcccag     2340

ttcctggaca cctgctgcaa ggccgccgac aaggacacct gtttcagcac cgagggcccc     2400

aacctggtga cccggtgcaa ggacgccctg gcccaccatc atcaccatca c              2451


<210>  227
<211>  212
<212>  PRT
<213>  Homo Sapien

<400>  227

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Asp Leu Ala Arg Thr Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  228
<211>  636
<212>  DNA
<213>  Homo Sapien

<400>  228
gacatcgagc tgacccagcc ccccagcgtg tctgtggccc ctggccagac cgcccggatc       60

agctgcagcg gcgacaacat cggcagcaaa tacgtgcact ggtatcagca gaagcccggc      120

caggcccccg tgctggtcat ctacggcgac agcaaccggc ccagcggcat ccccgagcgg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccgag      240

gacgaggccg actactactg cagcagctac gacctggccc ggaccgtgtt tggcggcgga      300

acaaagctga ccgtgctggg ccagcccaaa gccgccccta gcgtgaccct gttccccccc      360

agcagcgagg aactgcaggc caacaaggcc accctggtct gcctgatcag cgacttctac      420

cctggcgccg tgaccgtggc ctggaaggcc gacagcagcc ccgtgaaggc cggcgtggag      480

acaaccaccc ccagcaagca gagcaacaac aagtacgccg ccagcagcta cctgagcctg      540

acccccgagc agtggaagag ccacagaagc tacagctgcc aggtcaccca cgagggcagc      600

accgtggaga aaaccgtggc ccccaccgag tgcagc                                636


<210>  229
<211>  818
<212>  PRT
<213>  Homo Sapien

<400>  229

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Asn Ile Ser Gly Ser Ser Ser Phe Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp 
    210                 215                 220                 


Lys Thr His Thr Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn 
225                 230                 235                 240 


Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser 
                245                 250                 255     


Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln 
            260                 265                 270         


Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala 
        275                 280                 285             


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala 
    290                 295                 300                 


Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr 
305                 310                 315                 320 


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
                325                 330                 335     


Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys 
            340                 345                 350         


Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His 
        355                 360                 365             


Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr 
    370                 375                 380                 


Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala 
385                 390                 395                 400 


Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys 
                405                 410                 415     


Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln 
            420                 425                 430         


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
        435                 440                 445             


Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr 
    450                 455                 460                 


Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu 
465                 470                 475                 480 


Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln 
                485                 490                 495     


Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu 
            500                 505                 510         


Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala 
        515                 520                 525             


Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys 
    530                 535                 540                 


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr 
545                 550                 555                 560 


Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg 
                565                 570                 575     


Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala 
            580                 585                 590         


Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu 
        595                 600                 605             


Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu 
    610                 615                 620                 


Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr 
625                 630                 635                 640 


Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg 
                645                 650                 655     


Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln 
            660                 665                 670         


Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val 
        675                 680                 685             


Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys 
    690                 695                 700                 


Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr 
705                 710                 715                 720 


Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr 
                725                 730                 735     


Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys 
            740                 745                 750         


Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr 
        755                 760                 765             


Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp 
    770                 775                 780                 


Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly 
785                 790                 795                 800 


Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala His His His His 
                805                 810                 815     


His His 
        


<210>  230
<211>  2454
<212>  DNA
<213>  Homo Sapien

<400>  230
caggtgcagc tggtcgagtc tggcggggga ctggtccagc ctggcggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gtgaacggca tgcactgggt ccgccaggca      120

ccaggcaagg gcctggaatg ggtgtccaac atcagcggca gcagcagctt cacctactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgcg ggccgaggac accgccgtgt actactgcgc cagatacgac      300

tacatcaagt acggcgcctt cgacccctgg ggccagggca cactggtcac cgtgtccagc      360

gctagcacca agggccccag cgtgttcccc ctggccccca gcagcaagag cacctctggc      420

ggcactgctg ccctgggctg cctggtcaag gactacttcc ccgagcccgt gacagtgtcc      480

tggaacagcg gagccctgac ctccggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtcaca gtgcccagca gcagcctggg cacccagacc      600

tacatctgca acgtgaacca caagcccagc aacaccaagg tggacaagaa ggtggagccc      660

aagagctgcg acaagaccca caccgaggcc cacaagagcg agatcgccca ccggtacaac      720

gacctgggag agcagcattt caagggactg gtgctgatcg ccttcagcca gtacctgcag      780

aagtgcagct acgacgagca cgccaagctg gtgcaggaag tgaccgactt cgccaagacc      840

tgcgtggccg acgagagcgc cgccaactgc gacaagagcc tgcacaccct gttcggcgac      900

aagctgtgcg ccatccccaa cctgcgggag aactacggcg agctggccga ctgctgcacc      960

aagcaggaac ccgagcggaa cgagtgcttc ctgcagcaca aggacgacaa ccccagcctg     1020

ccccccttcg agaggcctga ggccgaggcc atgtgcacca gcttcaaaga gaaccccacc     1080

accttcatgg gccactacct gcacgaggtg gccaggcggc acccctactt ctacgccccc     1140

gagctgctgt actacgccga gcagtacaac gagatcctga cccagtgctg cgccgaggcc     1200

gacaaagaga gctgcctgac ccccaagctg gacggcgtga aagaaaaggc cctggtgtcc     1260

agcgtgcggc agcggatgaa gtgcagcagc atgcagaagt tcggcgagcg ggccttcaag     1320

gcctgggccg tggcccggct gtcccagacc ttccccaacg ccgatttcgc cgagatcacc     1380

aagctggcca ccgacctgac caaggtgaac aaagagtgct gtcacggcga cctgctggaa     1440

tgcgccgacg accgggccga gctggccaag tacatgtgcg agaaccaggc caccatcagc     1500

tccaaactgc agacctgctg tgataagccc ctgctgaaga aggcccactg cctgagcgag     1560

gtggagcacg acaccatgcc cgccgacctg cccgccattg ccgccgactt cgtggaggac     1620

caggaagtgt gcaagaatta cgccgaggcc aaggacgtgt tcctgggcac cttcctgtac     1680

gagtacagca gacggcaccc cgactacagc gtgagcctgc tgctgaggct ggccaagaag     1740

tacgaggcca ccctggaaaa gtgttgcgcc gaagccaacc cccctgcctg ctacggcacc     1800

gtgctggccg agttccagcc cctggtggag gaacccaaga acctggtgaa aaccaactgc     1860

gatctgtacg agaagctggg cgagtacggc ttccagaacg ccatcctggt ccggtacacc     1920

cagaaagccc cccaggtgtc cacccccaca ctggtggagg ccgccaggaa cctgggcaga     1980

gtcggcacca agtgctgcac cctgcccgag gatcagaggc tgccctgtgt cgaggactac     2040

ctgagcgcca tcctgaacag agtgtgcctg ctgcacgaga aaacccccgt gagcgagcac     2100

gtgaccaagt gttgcagcgg cagcctggtg gagcggaggc cctgcttcag cgccctgacc     2160

gtggacgaga catacgtgcc caaagagttc aaggccgaga cattcacctt ccacagcgac     2220

atctgtaccc tgcctgagaa agagaagcag atcaagaagc agaccgccct ggccgaactg     2280

gtgaagcaca agcccaaggc caccgccgag cagctgaaaa ccgtgatgga cgacttcgcc     2340

cagttcctgg acacctgctg caaggccgcc gacaaggaca cctgtttcag caccgagggc     2400

cccaacctgg tgacccggtg caaggacgcc ctggcccacc atcatcacca tcac           2454


<210>  231
<211>  214
<212>  PRT
<213>  Homo Sapien

<400>  231

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Arg Lys Lys Tyr Val 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Ala Asp Ser Gly Ile Asn Asn 
                85                  90                  95      


Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  232
<211>  642
<212>  DNA
<213>  Homo Sapien

<400>  232
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgataatat tcgtaagaag tatgtttatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgaggat tctaagcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ctctactgct gattctggta ttaataatgg tgtgtttggc      300

ggcggcacga agcttaccgt gctgggccag cccaaagccg cccctagcgt gaccctgttc      360

ccccccagca gcgaggaact gcaggccaac aaggccaccc tggtctgcct gatcagcgac      420

ttctaccctg gcgccgtgac cgtggcctgg aaggccgaca gcagccccgt gaaggccggc      480

gtggagacaa ccacccccag caagcagagc aacaacaagt acgccgccag cagctacctg      540

agcctgaccc ccgagcagtg gaagagccac agaagctaca gctgccaggt cacccacgag      600

ggcagcaccg tggagaaaac cgtggccccc accgagtgca gc                         642


<210>  233
<211>  821
<212>  PRT
<213>  Homo Sapien

<400>  233

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Ala Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Ser Gly Ser Ser Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ser His Gly Asn Ile Met Ala Lys Arg Tyr Phe Asp Phe 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
        115                 120                 125             


Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly 
    130                 135                 140                 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
145                 150                 155                 160 


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
                165                 170                 175     


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
            180                 185                 190         


Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val 
        195                 200                 205             


Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys 
    210                 215                 220                 


Ser Cys Asp Lys Thr His Thr Glu Ala His Lys Ser Glu Ile Ala His 
225                 230                 235                 240 


Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile 
                245                 250                 255     


Ala Phe Ser Gln Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys 
            260                 265                 270         


Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu 
        275                 280                 285             


Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
    290                 295                 300                 


Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp 
305                 310                 315                 320 


Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
                325                 330                 335     


Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu 
            340                 345                 350         


Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His 
        355                 360                 365             


Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
    370                 375                 380                 


Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys 
385                 390                 395                 400 


Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val 
                405                 410                 415     


Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser 
            420                 425                 430         


Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
        435                 440                 445             


Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys 
    450                 455                 460                 


Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp 
465                 470                 475                 480 


Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys 
                485                 490                 495     


Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys 
            500                 505                 510         


Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr 
        515                 520                 525             


Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln 
    530                 535                 540                 


Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr 
545                 550                 555                 560 


Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu 
                565                 570                 575     


Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys 
            580                 585                 590         


Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe 
        595                 600                 605             


Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp 
    610                 615                 620                 


Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val 
625                 630                 635                 640 


Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
                645                 650                 655     


Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro 
            660                 665                 670         


Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu 
        675                 680                 685             


Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His Val 
    690                 695                 700                 


Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser 
705                 710                 715                 720 


Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu 
                725                 730                 735     


Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys 
            740                 745                 750         


Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro 
        755                 760                 765             


Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln 
    770                 775                 780                 


Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser 
785                 790                 795                 800 


Thr Glu Gly Pro Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala His 
                805                 810                 815     


His His His His His 
            820     


<210>  234
<211>  2463
<212>  DNA
<213>  Homo Sapien

<400>  234
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gattatgcta ttcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatt ctggtagctc tacccattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtggttct      300

catggtaata ttatggctaa gcgttatttt gatttttggg gccaaggcac cctggtgacg      360

gttagctcag ctagcaccaa gggccccagc gtgttccccc tggcccccag cagcaagagc      420

acctctggcg gcactgctgc cctgggctgc ctggtcaagg actacttccc cgagcccgtg      480

acagtgtcct ggaacagcgg agccctgacc tccggcgtgc acaccttccc cgccgtgctg      540

cagagcagcg gcctgtacag cctgagcagc gtggtcacag tgcccagcag cagcctgggc      600

acccagacct acatctgcaa cgtgaaccac aagcccagca acaccaaggt cgacaagaag      660

gtggagccca agagctgcga caagacccac accgaggccc acaagagcga gatcgcccac      720

cggtacaacg acctgggaga gcagcatttc aagggactgg tgctgatcgc cttcagccag      780

tacctgcaga agtgcagcta cgacgagcac gccaagctgg tgcaggaagt gaccgacttc      840

gccaagacct gcgtggccga cgagagcgcc gccaactgcg acaagagcct gcacaccctg      900

ttcggcgaca agctgtgcgc catccccaac ctgcgggaga actacggcga gctggccgac      960

tgctgcacca agcaggaacc cgagcggaac gagtgcttcc tgcagcacaa ggacgacaac     1020

cccagcctgc cccccttcga gaggcctgag gccgaggcca tgtgcaccag cttcaaagag     1080

aaccccacca ccttcatggg ccactacctg cacgaggtgg ccaggcggca cccctacttc     1140

tacgcccccg agctgctgta ctacgccgag cagtacaacg agatcctgac ccagtgctgc     1200

gccgaggccg acaaagagag ctgcctgacc cccaagctgg acggcgtgaa agaaaaggcc     1260

ctggtgtcca gcgtgcggca gcggatgaag tgcagcagca tgcagaagtt cggcgagcgg     1320

gccttcaagg cctgggccgt ggcccggctg tcccagacct tccccaacgc cgatttcgcc     1380

gagatcacca agctggccac cgacctgacc aaggtgaaca aagagtgctg tcacggcgac     1440

ctgctggaat gcgccgacga ccgggccgag ctggccaagt acatgtgcga gaaccaggcc     1500

accatcagct ccaaactgca gacctgctgt gataagcccc tgctgaagaa ggcccactgc     1560

ctgagcgagg tggagcacga caccatgccc gccgacctgc ccgccattgc cgccgacttc     1620

gtggaggacc aggaagtgtg caagaattac gccgaggcca aggacgtgtt cctgggcacc     1680

ttcctgtacg agtacagcag acggcacccc gactacagcg tgagcctgct gctgaggctg     1740

gccaagaagt acgaggccac cctggaaaag tgttgcgccg aagccaaccc ccctgcctgc     1800

tacggcaccg tgctggccga gttccagccc ctggtggagg aacccaagaa cctggtgaaa     1860

accaactgcg atctgtacga gaagctgggc gagtacggct tccagaacgc catcctggtc     1920

cggtacaccc agaaagcccc ccaggtgtcc acccccacac tggtggaggc cgccaggaac     1980

ctgggcagag tcggcaccaa gtgctgcacc ctgcccgagg atcagaggct gccctgtgtc     2040

gaggactacc tgagcgccat cctgaacaga gtgtgcctgc tgcacgagaa aacccccgtg     2100

agcgagcacg tgaccaagtg ttgcagcggc agcctggtgg agcggaggcc ctgcttcagc     2160

gccctgaccg tggacgagac atacgtgccc aaagagttca aggccgagac attcaccttc     2220

cacagcgaca tctgtaccct gcctgagaaa gagaagcaga tcaagaagca gaccgccctg     2280

gccgaactgg tgaagcacaa gcccaaggcc accgccgagc agctgaaaac cgtgatggac     2340

gacttcgccc agttcctgga cacctgctgc aaggccgccg acaaggacac ctgtttcagc     2400

accgagggcc ccaacctggt gacccggtgc aaggacgccc tggcccacca tcatcaccat     2460

cac                                                                   2463


<210>  235
<211>  215
<212>  PRT
<213>  Homo Sapien

<400>  235

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 
        115                 120                 125             


Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 
    130                 135                 140                 


Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 
145                 150                 155                 160 


Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 
            180                 185                 190         


Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 
        195                 200                 205             


Ser Phe Asn Arg Gly Glu Cys 
    210                 215 


<210>  236
<211>  645
<212>  DNA
<213>  Homo Sapien

<400>  236
gatatcgtgc tgacccagag cccggcgacc ctgagcctgt ctccgggcga acgtgcgacc       60

ctgagctgca gagcgagcca gtttattggt tctcgttatc tggcttggta ccagcagaaa      120

ccaggtcaag caccgcgtct attaatttat ggtgcttcta atcgtgcaac tggggtcccg      180

gcgcgtttta gcggctctgg atccggcacg gattttaccc tgaccattag cagcctggaa      240

cctgaagact ttgcgactta ttattgccag cagtattatg attatcctca gacctttggc      300

cagggtacga aagttgaaat taaacgtacg gtggccgctc ccagcgtgtt catcttcccc      360

cccagcgacg agcagctgaa gagcggcacc gccagcgtgg tgtgcctgct gaacaacttc      420

tacccccggg aggccaaggt gcagtggaag gtggacaacg ccctgcagag cggcaacagc      480

caggagagcg tcaccgagca ggacagcaag gactccacct acagcctgag cagcaccctg      540

accctgagca aggccgacta cgagaagcat aaggtgtacg cctgcgaggt gacccaccag      600

ggcctgtcca gccccgtgac caagagcttc aacaggggcg agtgc                      645


<210>  237
<211>  817
<212>  PRT
<213>  Homo Sapien

<400>  237

Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
1               5                   10                  15      


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
            20                  25                  30          


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
        35                  40                  45              


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
    50                  55                  60                  


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
65                  70                  75                  80  


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 


Thr His Thr Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp 
225                 230                 235                 240 


Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln 
                245                 250                 255     


Tyr Leu Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu 
            260                 265                 270         


Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn 
        275                 280                 285             


Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile 
    290                 295                 300                 


Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys 
305                 310                 315                 320 


Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn 
                325                 330                 335     


Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr 
            340                 345                 350         


Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu 
        355                 360                 365             


Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr 
    370                 375                 380                 


Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp 
385                 390                 395                 400 


Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala 
                405                 410                 415     


Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys 
            420                 425                 430         


Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln 
        435                 440                 445             


Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp 
    450                 455                 460                 


Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys 
465                 470                 475                 480 


Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala 
                485                 490                 495     


Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys 
            500                 505                 510         


Lys Ala His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp 
        515                 520                 525             


Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys 
    530                 535                 540                 


Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu 
545                 550                 555                 560 


Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu 
                565                 570                 575     


Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn 
            580                 585                 590         


Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val 
        595                 600                 605             


Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys 
    610                 615                 620                 


Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln 
625                 630                 635                 640 


Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn 
                645                 650                 655     


Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg 
            660                 665                 670         


Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys 
        675                 680                 685             


Leu Leu His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys 
    690                 695                 700                 


Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val 
705                 710                 715                 720 


Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe 
                725                 730                 735     


His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys 
            740                 745                 750         


Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala 
        755                 760                 765             


Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr 
    770                 775                 780                 


Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro 
785                 790                 795                 800 


Asn Leu Val Thr Arg Cys Lys Asp Ala Leu Ala His His His His His 
                805                 810                 815     


His 
    


<210>  238
<211>  2451
<212>  DNA
<213>  Homo Sapien

<400>  238
caggtgcaat tgaaagaaag cggcccggcc ctggtgaaac cgacccaaac cctgaccctg       60

acctgtacct tttccggatt tagcctgtct aatcgtggtg gtggtgtggg ttggattcgc      120

cagccgcctg ggaaagccct cgagtggctg gcttggatcg attgggatga tgataagtct      180

tatagcacca gcctgaaaac gcgtctgacc attagcaaag atacttcgaa aaatcaggtg      240

gtgctgacta tgaccaacat ggacccggtg gatacggcca cctattattg cgcgcgtatg      300

catcttcctc ttgtttttga ttcttggggc caaggcaccc tggtgacggt tagctcagct      360

agcaccaagg gccccagcgt gttccccctg gcccccagca gcaagagcac cagcggcggc      420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg      480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc      540

ctgtacagcc tgtccagcgt ggtgacagtg cccagcagca gcctgggcac ccagacctac      600

atctgcaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag      660

agctgcgaca agacccacac cgaggcccac aagagcgaga tcgcccaccg gtacaacgac      720

ctgggagagc agcatttcaa gggactggtg ctgatcgcct tcagccagta cctgcagaag      780

tgcagctacg acgagcacgc caagctggtg caggaagtga ccgacttcgc caagacctgc      840

gtggccgacg agagcgccgc caactgcgac aagagcctgc acaccctgtt cggcgacaag      900

ctgtgcgcca tccccaacct gcgggagaac tacggcgagc tggccgactg ctgcaccaag      960

caggaacccg agcggaacga gtgcttcctg cagcacaagg acgacaaccc cagcctgccc     1020

cccttcgaga ggcctgaggc cgaggccatg tgcaccagct tcaaagagaa ccccaccacc     1080

ttcatgggcc actacctgca cgaggtggcc aggcggcacc cctacttcta cgcccccgag     1140

ctgctgtact acgccgagca gtacaacgag atcctgaccc agtgctgcgc cgaggccgac     1200

aaagagagct gcctgacccc caagctggac ggcgtgaaag aaaaggccct ggtgtccagc     1260

gtgcggcagc ggatgaagtg cagcagcatg cagaagttcg gcgagcgggc cttcaaggcc     1320

tgggccgtgg cccggctgtc ccagaccttc cccaacgccg atttcgccga gatcaccaag     1380

ctggccaccg acctgaccaa ggtgaacaaa gagtgctgtc acggcgacct gctggaatgc     1440

gccgacgacc gggccgagct ggccaagtac atgtgcgaga accaggccac catcagctcc     1500

aaactgcaga cctgctgtga taagcccctg ctgaagaagg cccactgcct gagcgaggtg     1560

gagcacgaca ccatgcccgc cgacctgccc gccattgccg ccgacttcgt ggaggaccag     1620

gaagtgtgca agaattacgc cgaggccaag gacgtgttcc tgggcacctt cctgtacgag     1680

tacagcagac ggcaccccga ctacagcgtg agcctgctgc tgaggctggc caagaagtac     1740

gaggccaccc tggaaaagtg ttgcgccgaa gccaaccccc ctgcctgcta cggcaccgtg     1800

ctggccgagt tccagcccct ggtggaggaa cccaagaacc tggtgaaaac caactgcgat     1860

ctgtacgaga agctgggcga gtacggcttc cagaacgcca tcctggtccg gtacacccag     1920

aaagcccccc aggtgtccac ccccacactg gtggaggccg ccaggaacct gggcagagtc     1980

ggcaccaagt gctgcaccct gcccgaggat cagaggctgc cctgtgtcga ggactacctg     2040

agcgccatcc tgaacagagt gtgcctgctg cacgagaaaa cccccgtgag cgagcacgtg     2100

accaagtgtt gcagcggcag cctggtggag cggaggccct gcttcagcgc cctgaccgtg     2160

gacgagacat acgtgcccaa agagttcaag gccgagacat tcaccttcca cagcgacatc     2220

tgtaccctgc ctgagaaaga gaagcagatc aagaagcaga ccgccctggc cgaactggtg     2280

aagcacaagc ccaaggccac cgccgagcag ctgaaaaccg tgatggacga cttcgcccag     2340

ttcctggaca cctgctgcaa ggccgccgac aaggacacct gtttcagcac cgagggcccc     2400

aacctggtga cccggtgcaa ggacgccctg gcccaccatc atcaccatca c              2451


<210>  239
<211>  847
<212>  PRT
<213>  Homo Sapien

<400>  239

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Glu Ala His Lys Ser Glu Ile Ala His Arg Tyr Asn Asp Leu Gly 
            260                 265                 270         


Glu Gln His Phe Lys Gly Leu Val Leu Ile Ala Phe Ser Gln Tyr Leu 
        275                 280                 285             


Gln Lys Cys Ser Tyr Asp Glu His Ala Lys Leu Val Gln Glu Val Thr 
    290                 295                 300                 


Asp Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Ala Asn Cys Asp 
305                 310                 315                 320 


Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Ala Ile Pro Asn 
                325                 330                 335     


Leu Arg Glu Asn Tyr Gly Glu Leu Ala Asp Cys Cys Thr Lys Gln Glu 
            340                 345                 350         


Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Ser 
        355                 360                 365             


Leu Pro Pro Phe Glu Arg Pro Glu Ala Glu Ala Met Cys Thr Ser Phe 
    370                 375                 380                 


Lys Glu Asn Pro Thr Thr Phe Met Gly His Tyr Leu His Glu Val Ala 
385                 390                 395                 400 


Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Tyr Tyr Ala Glu 
                405                 410                 415     


Gln Tyr Asn Glu Ile Leu Thr Gln Cys Cys Ala Glu Ala Asp Lys Glu 
            420                 425                 430         


Ser Cys Leu Thr Pro Lys Leu Asp Gly Val Lys Glu Lys Ala Leu Val 
        435                 440                 445             


Ser Ser Val Arg Gln Arg Met Lys Cys Ser Ser Met Gln Lys Phe Gly 
    450                 455                 460                 


Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Thr Phe 
465                 470                 475                 480 


Pro Asn Ala Asp Phe Ala Glu Ile Thr Lys Leu Ala Thr Asp Leu Thr 
                485                 490                 495     


Lys Val Asn Lys Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp 
            500                 505                 510         


Asp Arg Ala Glu Leu Ala Lys Tyr Met Cys Glu Asn Gln Ala Thr Ile 
        515                 520                 525             


Ser Ser Lys Leu Gln Thr Cys Cys Asp Lys Pro Leu Leu Lys Lys Ala 
    530                 535                 540                 


His Cys Leu Ser Glu Val Glu His Asp Thr Met Pro Ala Asp Leu Pro 
545                 550                 555                 560 


Ala Ile Ala Ala Asp Phe Val Glu Asp Gln Glu Val Cys Lys Asn Tyr 
                565                 570                 575     


Ala Glu Ala Lys Asp Val Phe Leu Gly Thr Phe Leu Tyr Glu Tyr Ser 
            580                 585                 590         


Arg Arg His Pro Asp Tyr Ser Val Ser Leu Leu Leu Arg Leu Ala Lys 
        595                 600                 605             


Lys Tyr Glu Ala Thr Leu Glu Lys Cys Cys Ala Glu Ala Asn Pro Pro 
    610                 615                 620                 


Ala Cys Tyr Gly Thr Val Leu Ala Glu Phe Gln Pro Leu Val Glu Glu 
625                 630                 635                 640 


Pro Lys Asn Leu Val Lys Thr Asn Cys Asp Leu Tyr Glu Lys Leu Gly 
                645                 650                 655     


Glu Tyr Gly Phe Gln Asn Ala Ile Leu Val Arg Tyr Thr Gln Lys Ala 
            660                 665                 670         


Pro Gln Val Ser Thr Pro Thr Leu Val Glu Ala Ala Arg Asn Leu Gly 
        675                 680                 685             


Arg Val Gly Thr Lys Cys Cys Thr Leu Pro Glu Asp Gln Arg Leu Pro 
    690                 695                 700                 


Cys Val Glu Asp Tyr Leu Ser Ala Ile Leu Asn Arg Val Cys Leu Leu 
705                 710                 715                 720 


His Glu Lys Thr Pro Val Ser Glu His Val Thr Lys Cys Cys Ser Gly 
                725                 730                 735     


Ser Leu Val Glu Arg Arg Pro Cys Phe Ser Ala Leu Thr Val Asp Glu 
            740                 745                 750         


Thr Tyr Val Pro Lys Glu Phe Lys Ala Glu Thr Phe Thr Phe His Ser 
        755                 760                 765             


Asp Ile Cys Thr Leu Pro Glu Lys Glu Lys Gln Ile Lys Lys Gln Thr 
    770                 775                 780                 


Ala Leu Ala Glu Leu Val Lys His Lys Pro Lys Ala Thr Ala Glu Gln 
785                 790                 795                 800 


Leu Lys Thr Val Met Asp Asp Phe Ala Gln Phe Leu Asp Thr Cys Cys 
                805                 810                 815     


Lys Ala Ala Asp Lys Asp Thr Cys Phe Ser Thr Glu Gly Pro Asn Leu 
            820                 825                 830         


Val Thr Arg Cys Lys Asp Ala Leu Ala His His His His His His 
        835                 840                 845         


<210>  240
<211>  2541
<212>  DNA
<213>  Homo Sapien

<400>  240
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cggcggaggc ggatccgggg gtggcggaag tgaggcccac      780

aagagcgaga tcgcccaccg gtacaacgac ctgggagagc agcatttcaa gggactggtg      840

ctgatcgcct tcagccagta cctgcagaag tgcagctacg acgagcacgc caagctggtg      900

caggaagtga ccgacttcgc caagacctgc gtggccgacg agagcgccgc caactgcgac      960

aagagcctgc acaccctgtt cggcgacaag ctgtgcgcca tccccaacct gcgggagaac     1020

tacggcgagc tggccgactg ctgcaccaag caggaacccg agcggaacga gtgcttcctg     1080

cagcacaagg acgacaaccc cagcctgccc cccttcgaga ggcctgaggc cgaggccatg     1140

tgcaccagct tcaaagagaa ccccaccacc ttcatgggcc actacctgca cgaggtggcc     1200

aggcggcacc cctacttcta cgcccccgag ctgctgtact acgccgagca gtacaacgag     1260

atcctgaccc agtgctgcgc cgaggccgac aaagagagct gcctgacccc caagctggac     1320

ggcgtgaaag aaaaggccct ggtgtccagc gtgcggcagc ggatgaagtg cagcagcatg     1380

cagaagttcg gcgagcgggc cttcaaggcc tgggccgtgg cccggctgtc ccagaccttc     1440

cccaacgccg atttcgccga gatcaccaag ctggccaccg acctgaccaa ggtgaacaaa     1500

gagtgctgtc acggcgacct gctggaatgc gccgacgacc gggccgagct ggccaagtac     1560

atgtgcgaga accaggccac catcagctcc aaactgcaga cctgctgtga taagcccctg     1620

ctgaagaagg cccactgcct gagcgaggtg gagcacgaca ccatgcccgc cgacctgccc     1680

gccattgccg ccgacttcgt ggaggaccag gaagtgtgca agaattacgc cgaggccaag     1740

gacgtgttcc tgggcacctt cctgtacgag tacagcagac ggcaccccga ctacagcgtg     1800

agcctgctgc tgaggctggc caagaagtac gaggccaccc tggaaaagtg ttgcgccgaa     1860

gccaaccccc ctgcctgcta cggcaccgtg ctggccgagt tccagcccct ggtggaggaa     1920

cccaagaacc tggtgaaaac caactgcgat ctgtacgaga agctgggcga gtacggcttc     1980

cagaacgcca tcctggtccg gtacacccag aaagcccccc aggtgtccac ccccacactg     2040

gtggaggccg ccaggaacct gggcagagtc ggcaccaagt gctgcaccct gcccgaggat     2100

cagaggctgc cctgtgtcga ggactacctg agcgccatcc tgaacagagt gtgcctgctg     2160

cacgagaaaa cccccgtgag cgagcacgtg accaagtgtt gcagcggcag cctggtggag     2220

cggaggccct gcttcagcgc cctgaccgtg gacgagacat acgtgcccaa agagttcaag     2280

gccgagacat tcaccttcca cagcgacatc tgtaccctgc ctgagaaaga gaagcagatc     2340

aagaagcaga ccgccctggc cgaactggtg aagcacaagc ccaaggccac cgccgagcag     2400

ctgaaaaccg tgatggacga cttcgcccag ttcctggaca cctgctgcaa ggccgccgac     2460

aaggacacct gtttcagcac cgagggcccc aacctggtga cccggtgcaa ggacgccctg     2520

gcccaccatc atcaccatca c                                               2541


<210>  241
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  241

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  242
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  242
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  243
<211>  1069
<212>  PRT
<213>  Homo Sapien

<400>  243

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Glu Ala His Lys Ser Glu Ile Ala 
225                 230                 235                 240 


His Arg Tyr Asn Asp Leu Gly Glu Gln His Phe Lys Gly Leu Val Leu 
                245                 250                 255     


Ile Ala Phe Ser Gln Tyr Leu Gln Lys Ser Ser Tyr Asp Glu His Ala 
            260                 265                 270         


Lys Leu Val Gln Glu Val Thr Asp Phe Ala Lys Thr Cys Val Ala Asp 
        275                 280                 285             


Glu Ser Ala Ala Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
    290                 295                 300                 


Lys Leu Cys Ala Ile Pro Asn Leu Arg Glu Asn Tyr Gly Glu Leu Ala 
305                 310                 315                 320 


Asp Cys Cys Thr Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
                325                 330                 335     


His Lys Asp Asp Asn Pro Ser Leu Pro Pro Phe Glu Arg Pro Glu Ala 
            340                 345                 350         


Glu Ala Met Cys Thr Ser Phe Lys Glu Asn Pro Thr Thr Phe Met Gly 
        355                 360                 365             


His Tyr Leu His Glu Val Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
    370                 375                 380                 


Glu Leu Leu Tyr Tyr Ala Glu Gln Tyr Asn Glu Ile Leu Thr Gln Cys 
385                 390                 395                 400 


Cys Ala Glu Ala Asp Lys Glu Ser Cys Leu Thr Pro Lys Leu Asp Gly 
                405                 410                 415     


Val Lys Glu Lys Ala Leu Val Ser Ser Val Arg Gln Arg Met Lys Cys 
            420                 425                 430         


Ser Ser Met Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
        435                 440                 445             


Ala Arg Leu Ser Gln Thr Phe Pro Asn Ala Asp Phe Ala Glu Ile Thr 
    450                 455                 460                 


Lys Leu Ala Thr Asp Leu Thr Lys Val Asn Lys Glu Cys Cys His Gly 
465                 470                 475                 480 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Glu Leu Ala Lys Tyr Met 
                485                 490                 495     


Cys Glu Asn Gln Ala Thr Ile Ser Ser Lys Leu Gln Thr Cys Cys Asp 
            500                 505                 510         


Lys Pro Leu Leu Lys Lys Ala His Cys Leu Ser Glu Val Glu His Asp 
        515                 520                 525             


Thr Met Pro Ala Asp Leu Pro Ala Ile Ala Ala Asp Phe Val Glu Asp 
    530                 535                 540                 


Gln Glu Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
545                 550                 555                 560 


Thr Phe Leu Tyr Glu Tyr Ser Arg Arg His Pro Asp Tyr Ser Val Ser 
                565                 570                 575     


Leu Leu Leu Arg Leu Ala Lys Lys Tyr Glu Ala Thr Leu Glu Lys Cys 
            580                 585                 590         


Cys Ala Glu Ala Asn Pro Pro Ala Cys Tyr Gly Thr Val Leu Ala Glu 
        595                 600                 605             


Phe Gln Pro Leu Val Glu Glu Pro Lys Asn Leu Val Lys Thr Asn Cys 
    610                 615                 620                 


Asp Leu Tyr Glu Lys Leu Gly Glu Tyr Gly Phe Gln Asn Ala Ile Leu 
625                 630                 635                 640 


Val Arg Tyr Thr Gln Lys Ala Pro Gln Val Ser Thr Pro Thr Leu Val 
                645                 650                 655     


Glu Ala Ala Arg Asn Leu Gly Arg Val Gly Thr Lys Cys Cys Thr Leu 
            660                 665                 670         


Pro Glu Asp Gln Arg Leu Pro Cys Val Glu Asp Tyr Leu Ser Ala Ile 
        675                 680                 685             


Leu Asn Arg Val Cys Leu Leu His Glu Lys Thr Pro Val Ser Glu His 
    690                 695                 700                 


Val Thr Lys Cys Cys Ser Gly Ser Leu Val Glu Arg Arg Pro Cys Phe 
705                 710                 715                 720 


Ser Ala Leu Thr Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Lys Ala 
                725                 730                 735     


Glu Thr Phe Thr Phe His Ser Asp Ile Cys Thr Leu Pro Glu Lys Glu 
            740                 745                 750         


Lys Gln Ile Lys Lys Gln Thr Ala Leu Ala Glu Leu Val Lys His Lys 
        755                 760                 765             


Pro Lys Ala Thr Ala Glu Gln Leu Lys Thr Val Met Asp Asp Phe Ala 
    770                 775                 780                 


Gln Phe Leu Asp Thr Cys Cys Lys Ala Ala Asp Lys Asp Thr Cys Phe 
785                 790                 795                 800 


Ser Thr Glu Gly Pro Asn Leu Val Thr Arg Ser Lys Asp Ala Leu Ala 
                805                 810                 815     


Gly Gly Ser Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala Thr 
            820                 825                 830         


Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser 
        835                 840                 845             


Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly 
    850                 855                 860                 


Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly 
865                 870                 875                 880 


Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu 
                885                 890                 895     


Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln 
            900                 905                 910         


Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu 
        915                 920                 925             


Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
    930                 935                 940                 


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Ala 
945                 950                 955                 960 


Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly 
                965                 970                 975     


Phe Ser Leu Ser Asn Arg Gly Gly Gly Val Gly Trp Ile Arg Gln Pro 
            980                 985                 990         


Pro Gly Lys Ala Leu Glu Trp Leu  Ala Trp Ile Asp Trp  Asp Asp Asp 
        995                 1000                 1005             


Lys Ser  Tyr Ser Thr Ser Leu  Lys Thr Arg Leu Thr  Ile Ser Lys 
    1010                 1015                 1020             


Asp Thr  Ser Lys Asn Gln Val  Val Leu Thr Met Thr  Asn Met Asp 
    1025                 1030                 1035             


Pro Val  Asp Thr Ala Thr Tyr  Tyr Cys Ala Arg Met  His Leu Pro 
    1040                 1045                 1050             


Leu Val  Phe Asp Ser Trp Gly  Gln Gly Thr Leu Val  Thr Val Ser 
    1055                 1060                 1065             


Ser 
    


<210>  244
<211>  3207
<212>  DNA
<213>  Homo Sapien

<400>  244
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacacttgtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcacctctg gcggcactgc tgccctgggc tgcctggtca aggactactt ccccgagccc      480

gtgacagtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtca cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtcgacaag      660

aaggtggagc ccaagagctg cgacaagacc cacaccgagg cccacaagag cgagatcgcc      720

caccggtaca acgacctggg agagcagcat ttcaagggac tggtgctgat cgccttcagc      780

cagtacctgc agaagtccag ctacgacgag cacgccaagc tggtgcagga agtgaccgac      840

ttcgccaaga cctgcgtggc cgacgagagc gccgccaact gcgacaagag cctgcacacc      900

ctgttcggcg acaagctgtg cgccatcccc aacctgcggg agaactacgg cgagctggcc      960

gactgctgca ccaagcagga acccgagcgg aacgagtgct tcctgcagca caaggacgac     1020

aaccccagcc tgcccccctt cgagaggcct gaggccgagg ccatgtgcac cagcttcaaa     1080

gagaacccca ccaccttcat gggccactac ctgcacgagg tggccaggcg gcacccctac     1140

ttctacgccc ccgagctgct gtactacgcc gagcagtaca acgagatcct gacccagtgc     1200

tgcgccgagg ccgacaaaga gagctgcctg acccccaagc tggacggcgt gaaagaaaag     1260

gccctggtgt ccagcgtgcg gcagcggatg aagtgcagca gcatgcagaa gttcggcgag     1320

cgggccttca aggcctgggc cgtggcccgg ctgtcccaga ccttccccaa cgccgatttc     1380

gccgagatca ccaagctggc caccgacctg accaaggtga acaaagagtg ctgtcacggc     1440

gacctgctgg aatgcgccga cgaccgggcc gagctggcca agtacatgtg cgagaaccag     1500

gccaccatca gctccaaact gcagacctgc tgtgataagc ccctgctgaa gaaggcccac     1560

tgcctgagcg aggtggagca cgacaccatg cccgccgacc tgcccgccat tgccgccgac     1620

ttcgtggagg accaggaagt gtgcaagaat tacgccgagg ccaaggacgt gttcctgggc     1680

accttcctgt acgagtacag cagacggcac cccgactaca gcgtgagcct gctgctgagg     1740

ctggccaaga agtacgaggc caccctggaa aagtgttgcg ccgaagccaa cccccctgcc     1800

tgctacggca ccgtgctggc cgagttccag cccctggtgg aggaacccaa gaacctggtg     1860

aaaaccaact gcgatctgta cgagaagctg ggcgagtacg gcttccagaa cgccatcctg     1920

gtccggtaca cccagaaagc cccccaggtg tccaccccca cactggtgga ggccgccagg     1980

aacctgggca gagtcggcac caagtgctgc accctgcccg aggatcagag gctgccctgt     2040

gtcgaggact acctgagcgc catcctgaac agagtgtgcc tgctgcacga gaaaaccccc     2100

gtgagcgagc acgtgaccaa gtgttgcagc ggcagcctgg tggagcggag gccctgcttc     2160

agcgccctga ccgtggacga gacatacgtg cccaaagagt tcaaggccga gacattcacc     2220

ttccacagcg acatctgtac cctgcctgag aaagagaagc agatcaagaa gcagaccgcc     2280

ctggccgaac tggtgaagca caagcccaag gccaccgccg agcagctgaa aaccgtgatg     2340

gacgacttcg cccagttcct ggacacctgc tgcaaggccg ccgacaagga cacctgtttc     2400

agcaccgagg gccccaacct ggtgacccgg tccaaggacg ccctggccgg cggctccggc     2460

ggaagcgata tcgtgctgac acagagccct gccaccctgt ctctgagccc tggcgagaga     2520

gccaccctga gctgccgggc cagccagttc atcggctccc gctacctggc ctggtatcag     2580

cagaagcccg gacaggctcc cagactgctg atctacggcg ccagcaacag agctaccggc     2640

gtgcccgcca gattttctgg cagcggcagc ggcaccgact tcaccctgac catcagcagc     2700

ctggaacccg aggacttcgc cacctactac tgccagcagt actacgacta cccccagacc     2760

ttcggccagg gcaccaaggt ggagatcaag ggcggaggcg gatccggggg tggcggaagt     2820

ggaggcggag gaagcggagg gggcggaagc caggtgcaat tgaaagagtc cggccctgcc     2880

ctggtgaagc ctacccagac cctgaccctg acatgcacct tcagcggctt cagcctgagc     2940

aacagaggcg gcggagtggg ctggatcaga cagcctcccg gcaaggccct ggaatggctg     3000

gcctggatcg actgggacga cgacaagagc tacagcacca gcctgaaaac ccggctgacc     3060

atctccaagg acaccagcaa gaaccaggtg gtgctcacca tgaccaacat ggaccccgtg     3120

gacaccgcca cctattattg cgcccggatg catctgcccc tggtgttcga tagctggggc     3180

cagggaaccc tggtgacagt gtccagc                                         3207


<210>  245
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  245

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  246
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  246
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  247
<211>  1070
<212>  PRT
<213>  Homo Sapien

<400>  247

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Asp Ala His Lys Ser Glu Val Ala 
225                 230                 235                 240 


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
                245                 250                 255     


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 
            260                 265                 270         


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
        275                 280                 285             


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
    290                 295                 300                 


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
305                 310                 315                 320 


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
                325                 330                 335     


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
            340                 345                 350         


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
        355                 360                 365             


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
    370                 375                 380                 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
385                 390                 395                 400 


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
                405                 410                 415     


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
            420                 425                 430         


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
        435                 440                 445             


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
    450                 455                 460                 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
465                 470                 475                 480 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
                485                 490                 495     


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
            500                 505                 510         


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
        515                 520                 525             


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
    530                 535                 540                 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
545                 550                 555                 560 


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
                565                 570                 575     


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
            580                 585                 590         


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
        595                 600                 605             


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
    610                 615                 620                 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
625                 630                 635                 640 


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
                645                 650                 655     


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
            660                 665                 670         


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
        675                 680                 685             


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
    690                 695                 700                 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
705                 710                 715                 720 


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
                725                 730                 735     


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
            740                 745                 750         


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
        755                 760                 765             


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
    770                 775                 780                 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
785                 790                 795                 800 


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
                805                 810                 815     


Leu Gly Gly Ser Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
            820                 825                 830         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        835                 840                 845             


Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    850                 855                 860                 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala Thr 
865                 870                 875                 880 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                885                 890                 895     


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            900                 905                 910         


Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val 
        915                 920                 925             


Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
    930                 935                 940                 


Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro 
945                 950                 955                 960 


Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser 
                965                 970                 975     


Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val Gly Trp Ile Arg Gln 
            980                 985                 990         


Pro Pro Gly Lys Ala Leu Glu Trp  Leu Ala Trp Ile Asp  Trp Asp Asp 
        995                 1000                 1005             


Asp Lys  Ser Tyr Ser Thr Ser  Leu Lys Thr Arg Leu  Thr Ile Ser 
    1010                 1015                 1020             


Lys Asp  Thr Ser Lys Asn Gln  Val Val Leu Thr Met  Thr Asn Met 
    1025                 1030                 1035             


Asp Pro  Val Asp Thr Ala Thr  Tyr Tyr Cys Ala Arg  Met His Leu 
    1040                 1045                 1050             


Pro Leu  Val Phe Asp Ser Trp  Gly Gln Gly Thr Leu  Val Thr Val 
    1055                 1060                 1065             


Ser Ser  
    1070 


<210>  248
<211>  3210
<212>  DNA
<213>  Homo Sapien

<400>  248
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc ctccagcaag      420

tccacaagcg gtggcacagc agctctgggt tgcctggtga aggactactt ccccgagccc      480

gtgacagtgt cctggaactc tggcgccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga cagtccccag cagcagcttg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

aaggtggagc ccaagagctg cgacaagacc cacaccgacg cccacaagag cgaggtggcc      720

caccggttca aggacctggg cgaggaaaac ttcaaggccc tggtgctgat cgccttcgcc      780

cagtacctgc agcagagccc cttcgaagat cacgtaaagt tagtcaacga ggttacggaa      840

ttcgcaaaga catgcgttgc tgacgaatcc gctgagaatt gtgacaagag tttgcacact      900

ttattcggag ataagttgtg tactgtagct actttgagag agacttacgg tgaaatggct      960

gactgctgtg caaaacagga accagaacgt aacgaatgtt tccttcagca taaggatgat     1020

aaccctaacc ttccaaggct tgttaggcca gaagtcgacg tgatgtgcac cgccttccat     1080

gataatgaag agacttttct taaaaagtac ctatacgaga ttgcaaggcg tcatccatat     1140

ttttacgccc cagagctgtt gtttttcgca aagagataca aagctgcatt tactgagtgt     1200

tgccaagctg ccgacaaggc cgcttgtttg ctaccaaagt tggacgaatt gagagacgag     1260

ggtaaggcat catctgccaa gcagagatta aaatgtgcat ctttgcaaaa atttggagag     1320

agagctttta aggcatgggc tgttgcccga ctaagccaaa gattcccaaa agccgaattt     1380

gctgaagtat ccaagctggt gactgatttg actaaagtac atacagaatg ttgccatggc     1440

gaccttttag aatgtgctga tgacagagca gatttggcta agtatatctg cgaaaatcaa     1500

gattcaatca gctctaagct gaaggaatgt tgcgagaaac cactgttaga aaaatcgcat     1560

tgtattgctg aagttgaaaa tgatgagatg cctgctgact tgccttctct tgccgctgat     1620

tttgttgagt cgaaggatgt ctgtaagaat tatgctgaag ctaaagacgt tttcctgggt     1680

atgttcttat atgagtacgc aagacgtcac ccagattact ctgtggttct gctactgaga     1740

ttggctaaaa catacgagac aacgctggag aagtgctgtg ctgccgctga ccctcatgag     1800

tgctatgcaa aggtttttga tgaattcaaa ccattggttg aagagcctca aaacttgata     1860

aagcagaact gtgagctgtt tgagcaattg ggtgagtata agttccaaaa tgccctgttg     1920

gtgagatata caaaaaaggt accccaagtt tcaacgccca ctttagttga agtgtccaga     1980

aatcttggta aagtgggtag caaatgttgc aagcatccag aagccaagcg aatgccctgt     2040

gctgaggatt atctgtccgt cgtgttgaac caattgtgcg tattacacga aaaaacccca     2100

gtctctgata gagtcaccaa atgttgcact gagtcactag ttaatagaag gccttgtttt     2160

tccgctttgg aagttgatga aacctacgtg cctaaggaat ttaacgctga gacctttacc     2220

tttcacgctg acatttgtac tttgagtgaa aaagagcgtc aaatcaaaaa gcaaaccgct     2280

cttgttgaat tggtgaaaca caagcctaag gctacgaagg agcagcttaa agccgtcatg     2340

gacgatttcg ccgcatttgt tgaaaaatgc tgtaaagctg atgacaagga aacatgtttc     2400

gctgaagagg gaaagaaatt ggttgcggcc agtcaggcag cgcttggttt gggcggctcc     2460

ggcggaagcg atatcgtgct gacacagagc cctgccaccc tgtctctgag ccctggcgag     2520

agagccaccc tgagctgccg ggccagccag ttcatcggct cccgctacct ggcctggtat     2580

cagcagaagc ccggacaggc tcccagactg ctgatctacg gcgccagcaa cagagctacc     2640

ggcgtgcccg ccagattttc tggcagcggc agcggcaccg acttcaccct gaccatcagc     2700

agcctggaac ccgaggactt cgccacctac tactgccagc agtactacga ctacccccag     2760

accttcggcc agggcaccaa ggtggagatc aagggcggag gcggatccgg gggtggcgga     2820

agtggaggcg gaggaagcgg agggggcgga agccaggtgc aattgaaaga gtccggccct     2880

gccctggtga agcctaccca gaccctgacc ctgacatgca ccttcagcgg cttcagcctg     2940

agcaacagag gcggcggagt gggctggatc agacagcctc ccggcaaggc cctggaatgg     3000

ctggcctgga tcgactggga cgacgacaag agctacagca ccagcctgaa aacccggctg     3060

accatctcca aggacaccag caagaaccag gtggtgctca ccatgaccaa catggacccc     3120

gtggacaccg ccacctatta ttgcgcccgg atgcatctgc ccctggtgtt cgatagctgg     3180

ggccagggaa ccctggtgac agtgtccagc                                      3210


<210>  249
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  249

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  250
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  250
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  251
<211>  1290
<212>  PRT
<213>  Homo Sapien

<400>  251

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Asp Ala His Lys Ser Glu Val Ala 
225                 230                 235                 240 


His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 
                245                 250                 255     


Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val 
            260                 265                 270         


Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp 
        275                 280                 285             


Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 
    290                 295                 300                 


Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 
305                 310                 315                 320 


Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 
                325                 330                 335     


His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 
            340                 345                 350         


Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys 
        355                 360                 365             


Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 
    370                 375                 380                 


Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 
385                 390                 395                 400 


Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 
                405                 410                 415     


Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 
            420                 425                 430         


Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val 
        435                 440                 445             


Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 
    450                 455                 460                 


Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 
465                 470                 475                 480 


Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 
                485                 490                 495     


Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 
            500                 505                 510         


Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp 
        515                 520                 525             


Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 
    530                 535                 540                 


Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 
545                 550                 555                 560 


Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 
                565                 570                 575     


Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 
            580                 585                 590         


Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu 
        595                 600                 605             


Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 
    610                 615                 620                 


Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 
625                 630                 635                 640 


Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 
                645                 650                 655     


Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 
            660                 665                 670         


Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val 
        675                 680                 685             


Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 
    690                 695                 700                 


Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 
705                 710                 715                 720 


Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 
                725                 730                 735     


Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 
            740                 745                 750         


Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys 
        755                 760                 765             


Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 
    770                 775                 780                 


Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 
785                 790                 795                 800 


Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 
                805                 810                 815     


Leu Gly Gly Ser Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro Ala 
            820                 825                 830         


Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala 
        835                 840                 845             


Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
    850                 855                 860                 


Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala Thr 
865                 870                 875                 880 


Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                885                 890                 895     


Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 
            900                 905                 910         


Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val 
        915                 920                 925             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    930                 935                 940                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
945                 950                 955                 960 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                965                 970                 975     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            980                 985                 990         


Lys Asp Ser Thr Tyr Ser Leu Ser  Ser Thr Leu Thr Leu  Ser Lys Ala 
        995                 1000                 1005             


Asp Tyr  Glu Lys His Lys Val  Tyr Ala Cys Glu Val  Thr His Gln 
    1010                 1015                 1020             


Gly Leu  Ser Ser Pro Val Thr  Lys Ser Phe Asn Arg  Gly Glu Cys 
    1025                 1030                 1035             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1040                 1045                 1050             


Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser Gly Gly  Gly Gly Ser 
    1055                 1060                 1065             


Gln Val  Gln Leu Lys Glu Ser  Gly Pro Ala Leu Val  Lys Pro Thr 
    1070                 1075                 1080             


Gln Thr  Leu Thr Leu Thr Cys  Thr Phe Ser Gly Phe  Ser Leu Ser 
    1085                 1090                 1095             


Asn Arg  Gly Gly Gly Val Gly  Trp Ile Arg Gln Pro  Pro Gly Lys 
    1100                 1105                 1110             


Ala Leu  Glu Trp Leu Ala Trp  Ile Asp Trp Asp Asp  Asp Lys Ser 
    1115                 1120                 1125             


Tyr Ser  Thr Ser Leu Lys Thr  Arg Leu Thr Ile Ser  Lys Asp Thr 
    1130                 1135                 1140             


Ser Lys  Asn Gln Val Val Leu  Thr Met Thr Asn Met  Asp Pro Val 
    1145                 1150                 1155             


Asp Thr  Ala Thr Tyr Tyr Cys  Ala Arg Met His Leu  Pro Leu Val 
    1160                 1165                 1170             


Phe Asp  Ser Trp Gly Gln Gly  Thr Leu Val Thr Val  Ser Ser Ala 
    1175                 1180                 1185             


Ser Thr  Lys Gly Pro Ser Val  Phe Pro Leu Ala Pro  Ser Ser Lys 
    1190                 1195                 1200             


Ser Thr  Ser Gly Gly Thr Ala  Ala Leu Gly Cys Leu  Val Lys Asp 
    1205                 1210                 1215             


Tyr Phe  Pro Glu Pro Val Thr  Val Ser Trp Asn Ser  Gly Ala Leu 
    1220                 1225                 1230             


Thr Ser  Gly Val His Thr Phe  Pro Ala Val Leu Gln  Ser Ser Gly 
    1235                 1240                 1245             


Leu Tyr  Ser Leu Ser Ser Val  Val Thr Val Pro Ser  Ser Ser Leu 
    1250                 1255                 1260             


Gly Thr  Gln Thr Tyr Ile Cys  Asn Val Asn His Lys  Pro Ser Asn 
    1265                 1270                 1275             


Thr Lys  Val Asp Lys Arg Val  Glu Pro Lys Ser Cys  
    1280                 1285                 1290 


<210>  252
<211>  3870
<212>  DNA
<213>  Homo Sapien

<400>  252
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc ctccagcaag      420

tccacaagcg gtggcacagc agctctgggt tgcctggtga aggactactt ccccgagccc      480

gtgacagtgt cctggaactc tggcgccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga cagtccccag cagcagcttg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

aaggtggagc ccaagagctg cgacaagacc cacaccgacg cccacaagag cgaggtggcc      720

caccggttca aggacctggg cgaggaaaac ttcaaggccc tggtgctgat cgccttcgcc      780

cagtacctgc agcagagccc cttcgaagat cacgtaaagt tagtcaacga ggttacggaa      840

ttcgcaaaga catgcgttgc tgacgaatcc gctgagaatt gtgacaagag tttgcacact      900

ttattcggag ataagttgtg tactgtagct actttgagag agacttacgg tgaaatggct      960

gactgctgtg caaaacagga accagaacgt aacgaatgtt tccttcagca taaggatgat     1020

aaccctaacc ttccaaggct tgttaggcca gaagtcgacg tgatgtgcac cgccttccat     1080

gataatgaag agacttttct taaaaagtac ctatacgaga ttgcaaggcg tcatccatat     1140

ttttacgccc cagagctgtt gtttttcgca aagagataca aagctgcatt tactgagtgt     1200

tgccaagctg ccgacaaggc cgcttgtttg ctaccaaagt tggacgaatt gagagacgag     1260

ggtaaggcat catctgccaa gcagagatta aaatgtgcat ctttgcaaaa atttggagag     1320

agagctttta aggcatgggc tgttgcccga ctaagccaaa gattcccaaa agccgaattt     1380

gctgaagtat ccaagctggt gactgatttg actaaagtac atacagaatg ttgccatggc     1440

gaccttttag aatgtgctga tgacagagca gatttggcta agtatatctg cgaaaatcaa     1500

gattcaatca gctctaagct gaaggaatgt tgcgagaaac cactgttaga aaaatcgcat     1560

tgtattgctg aagttgaaaa tgatgagatg cctgctgact tgccttctct tgccgctgat     1620

tttgttgagt cgaaggatgt ctgtaagaat tatgctgaag ctaaagacgt tttcctgggt     1680

atgttcttat atgagtacgc aagacgtcac ccagattact ctgtggttct gctactgaga     1740

ttggctaaaa catacgagac aacgctggag aagtgctgtg ctgccgctga ccctcatgag     1800

tgctatgcaa aggtttttga tgaattcaaa ccattggttg aagagcctca aaacttgata     1860

aagcagaact gtgagctgtt tgagcaattg ggtgagtata agttccaaaa tgccctgttg     1920

gtgagatata caaaaaaggt accccaagtt tcaacgccca ctttagttga agtgtccaga     1980

aatcttggta aagtgggtag caaatgttgc aagcatccag aagccaagcg aatgccctgt     2040

gctgaggatt atctgtccgt cgtgttgaac caattgtgcg tattacacga aaaaacccca     2100

gtctctgata gagtcaccaa atgttgcact gagtcactag ttaatagaag gccttgtttt     2160

tccgctttgg aagttgatga aacctacgtg cctaaggaat ttaacgctga gacctttacc     2220

tttcacgctg acatttgtac tttgagtgaa aaagagcgtc aaatcaaaaa gcaaaccgct     2280

cttgttgaat tggtgaaaca caagcctaag gctacgaagg agcagcttaa agccgtcatg     2340

gacgatttcg ccgcatttgt tgaaaaatgc tgtaaagctg atgacaagga aacatgtttc     2400

gctgaagagg gaaagaaatt ggttgcggcc agtcaggcag cgcttggttt gggcggctcc     2460

ggcggaagcg atatcgtgct gacccagagc ccggcgaccc tgagcctgtc tccgggcgaa     2520

cgtgcgaccc tgagctgcag agcgagccag tttattggtt ctcgttatct ggcttggtac     2580

cagcagaaac caggtcaagc accgcgtcta ttaatttatg gtgcttctaa tcgtgcaact     2640

ggggtcccgg cgcgttttag cggctctgga tccggcacgg attttaccct gaccattagc     2700

agcctggaac ctgaagactt tgcgacttat tattgccagc agtattatga ttatcctcag     2760

acctttggcc agggtacgaa agttgaaatt aaacgtacgg tggccgctcc cagcgtgttc     2820

atcttccccc ccagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgcctgctg     2880

aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc     2940

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc     3000

agcaccctga ccctgagcaa ggccgactac gagaagcata aggtgtacgc ctgcgaggtg     3060

acgcaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgcggaggt     3120

gggggatcgg gaggaggtgg gtcaggtgga ggagggtcag ggggaggggg ctcgggaggc     3180

ggtggctccg gagggggtgg gagccaagtg caattgaaag aaagcggccc ggccctggtg     3240

aaaccgaccc aaaccctgac cctgacctgt accttttccg gatttagcct gtctaatcgt     3300

ggtggtggtg tgggttggat tcgccagccg cctgggaaag ccctcgagtg gctggcttgg     3360

atcgattggg atgatgataa gtcttatagc accagcctga aaacgcgtct gaccattagc     3420

aaagatactt cgaaaaatca ggtggtgctg actatgacca acatggaccc ggtggatacg     3480

gccacctatt attgcgcgcg tatgcatctt cctcttgttt ttgattcttg gggccaaggc     3540

accctggtga cggttagctc agctagcacc aagggcccca gcgtgttccc cctggccccc     3600

agcagcaaga gcaccagcgg cggcacagcc gccctgggct gcctggtgaa ggactacttc     3660

cccgagcccg tgaccgtgtc ctggaacagc ggagccctga cctccggcgt gcacaccttc     3720

cccgccgtgc tgcagagcag cggcctgtac agcctgtcca gcgtggtgac agtgcccagc     3780

agcagcctgg gcacccagac ctacatctgc aacgtgaacc acaagcccag caacaccaag     3840

gtggacaaga gagtggagcc caagagctgc                                      3870


<210>  253
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  253

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  254
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  254
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  255
<211>  707
<212>  PRT
<213>  Homo Sapien

<400>  255

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Gly Pro Pro Gly Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Thr Leu Asp Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu 
    450                 455                 460                 


Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr 
465                 470                 475                 480 


Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp 
                485                 490                 495     


Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala 
            500                 505                 510         


Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser 
        515                 520                 525             


Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe 
    530                 535                 540                 


Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly 
545                 550                 555                 560 


Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly 
                565                 570                 575     


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu 
            580                 585                 590         


Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu 
        595                 600                 605             


Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val 
    610                 615                 620                 


Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp 
625                 630                 635                 640 


Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg 
                645                 650                 655     


Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met 
            660                 665                 670         


Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met 
        675                 680                 685             


His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr 
    690                 695                 700                 


Val Ser Ser 
705         


<210>  256
<211>  2121
<212>  DNA
<213>  Homo Sapien

<400>  256
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgtcc agcgtggtga cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacaccggcc cccccggccc agccccagag      720

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1020

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcaccctgg acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga agcgctgcac     1320

aaccactaca cccagaagag cctgagcctg tcccccggca agggcggctc cggcggaagc     1380

gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc     1440

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag     1500

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc     1560

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa     1620

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc     1680

cagggcacca aggtggagat caagggcgga ggcggatccg ggggtggcgg aagtggaggc     1740

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg     1800

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga     1860

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg     1920

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc     1980

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc     2040

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga     2100

accctggtga cagtgtccag c                                               2121


<210>  257
<211>  211
<212>  PRT
<213>  Homo Sapien

<400>  257

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
            20                  25                  30          


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
        35                  40                  45              


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
    50                  55                  60                  


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
                85                  90                  95      


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala Pro 
            100                 105                 110         


Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn Lys 
        115                 120                 125             


Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val Thr 
    130                 135                 140                 


Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu Thr 
145                 150                 155                 160 


Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser Tyr 
                165                 170                 175     


Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser Cys 
            180                 185                 190         


Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro Thr 
        195                 200                 205             


Glu Cys Ser 
    210     


<210>  258
<211>  633
<212>  DNA
<213>  Homo Sapien

<400>  258
gacatcgagc tgacccagcc cccttctgtg tctgtggccc ctggccagac cgccagaatc       60

agctgcagcg gcgacagcct gcggaacaag gtgtactggt atcagcagaa gcccggccag      120

gctcccgtgc tggtgatcta caagaacaac cggcccagcg gcatccctga gcggttcagc      180

ggcagcaaca gcggcaatac cgccaccctg accatcagcg gcacccaggc cgaagatgag      240

gccgactact actgccagag ctacgacggc cagaaaagcc tggtgttcgg cggaggcacc      300

aagcttaccg tgctgggcca gcccaaagcc gcccctagcg tgaccctgtt cccccccagc      360

agcgaggaac tgcaggccaa caaggccacc ctggtctgcc tgatcagcga cttctaccct      420

ggcgccgtga ccgtggcctg gaaggccgac agcagccccg tgaaggccgg cgtggagaca      480

accaccccca gcaagcagag caacaacaag tacgccgcca gcagctacct gagcctgacc      540

cccgagcagt ggaagagcca cagaagctac agctgccagg tcacccacga gggcagcacc      600

gtggagaaaa ccgtggcccc caccgagtgc agc                                   633


<210>  259
<211>  929
<212>  PRT
<213>  Homo Sapien

<400>  259

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly 
    130                 135                 140                 


Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn 
        195                 200                 205             


Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Gly Pro Pro Gly Pro Ala Pro Glu 
225                 230                 235                 240 


Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Thr Leu Asp Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys Ser Pro Pro Ser Pro Ala Pro Glu Ala Ala 
    450                 455                 460                 


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
465                 470                 475                 480 


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                485                 490                 495     


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            500                 505                 510         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        515                 520                 525             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    530                 535                 540                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
545                 550                 555                 560 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                565                 570                 575     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            580                 585                 590         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        595                 600                 605             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    610                 615                 620                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Thr Leu Asp Ser Lys Leu Thr 
625                 630                 635                 640 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                645                 650                 655     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            660                 665                 670         


Ser Pro Gly Lys Gly Gly Ser Gly Gly Ser Asp Ile Val Leu Thr Gln 
        675                 680                 685             


Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 
    690                 695                 700                 


Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln 
705                 710                 715                 720 


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn 
                725                 730                 735     


Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr 
            740                 745                 750         


Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr 
        755                 760                 765             


Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly 
    770                 775                 780                 


Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
785                 790                 795                 800 


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu 
                805                 810                 815     


Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys 
            820                 825                 830         


Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val Gly Trp 
        835                 840                 845             


Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp Ile Asp 
    850                 855                 860                 


Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg Leu Thr 
865                 870                 875                 880 


Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr Asn 
                885                 890                 895     


Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Met His Leu 
            900                 905                 910         


Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
        915                 920                 925             


Ser 
    


<210>  260
<211>  2787
<212>  DNA
<213>  Homo Sapien

<400>  260
caggtgcaat tggtcgagtc tggcggagga ctggtgcagc ctggtggcag cctgagactg       60

agctgcgccg ccagcggctt caccttcagc gactacgtga tcaactgggt gcgacaggcc      120

cctggaaagg gcctggaatg ggtgtccggc atctcttggt ctggcgtgaa cacccactac      180

gccgacagcg tgaagggccg gttcaccatc agccgggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag agccgaggac accgccgtgt actactgtgc cagactgggc      300

gccaccgcca acaacatccg gtacaagttc atggacgtgt ggggccaggg cacactggtg      360

accgtcagct cagctagcac caagggcccc agcgtgttcc ccctggcccc cagcagcaag      420

agcaccagcg gcggcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtgt cctggaacag cggagccctg acctccggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgtcc agcgtggtga cagtgcccag cagcagcctg      600

ggcacccaga cctacatctg caacgtgaac cacaagccca gcaacaccaa ggtggacaag      660

agagtggagc ccaagagctg cgacaagacc cacaccggcc cccccggccc agccccagag      720

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      780

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      840

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      900

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg      960

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1020

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1080

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1140

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1200

acccccccag tgctggacag cgacggcagc ttcaccctgg acagcaagct gaccgtggac     1260

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga agcgctgcac     1320

aaccactaca cccagaagag cctgagcctg tcccccggca agtccccccc ctccccagcc     1380

ccagaggcag cgggcggacc ctccgtgttc ctgttccccc ccaagcccaa ggacaccctg     1440

atgatcagca ggacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggaccca     1500

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc     1560

agagaggagc agtacaacag cacctacagg gtggtgtccg tgctgaccgt gctgcaccag     1620

gactggctga acggcaagga atacaagtgc aaggtctcca acaaggccct gccagccccc     1680

atcgaaaaga ccatcagcaa ggccaagggc cagccacggg agccccaggt gtacaccctg     1740

cccccctccc gggaggagat gaccaagaac caggtgtccc tgacctgtct ggtgaagggc     1800

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac     1860

aagaccaccc ccccagtgct ggacagcgac ggcagcttca ccctggacag caagctgacc     1920

gtggacaagt ccaggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaagcc     1980

ctgcacaacc actacaccca gaagagcctg agcctgtccc ccggcaaggg cggctccggc     2040

ggaagcgata tcgtgctgac acagagccct gccaccctgt ctctgagccc tggcgagaga     2100

gccaccctga gctgccgggc cagccagttc atcggctccc gctacctggc ctggtatcag     2160

cagaagcccg gacaggctcc cagactgctg atctacggcg ccagcaacag agctaccggc     2220

gtgcccgcca gattttctgg cagcggcagc ggcaccgact tcaccctgac catcagcagc     2280

ctggaacccg aggacttcgc cacctactac tgccagcagt actacgacta cccccagacc     2340

ttcggccagg gcaccaaggt ggagatcaag ggcggaggcg gatccggggg tggcggaagt     2400

ggaggcggag gaagcggagg gggcggaagc caggtgcaat tgaaagagtc cggccctgcc     2460

ctggtgaagc ctacccagac cctgaccctg acatgcacct tcagcggctt cagcctgagc     2520

aacagaggcg gcggagtggg ctggatcaga cagcctcccg gcaaggccct ggaatggctg     2580

gcctggatcg actgggacga cgacaagagc tacagcacca gcctgaaaac ccggctgacc     2640

atctccaagg acaccagcaa gaaccaggtg gtgctcacca tgaccaacat ggaccccgtg     2700

gacaccgcca cctattattg cgcccggatg catctgcccc tggtgttcga tagctggggc     2760

cagggaaccc tggtgacagt gtccagc                                         2787


<210>  261
<211>  213
<212>  PRT
<213>  Homo Sapien

<400>  261

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Asn Ile Gly Ser Lys Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Gly Asp Ser Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Thr Arg Thr Ser Thr Pro Ile Ser Gly 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Ala Cys 
    210             


<210>  262
<211>  639
<212>  DNA
<213>  Homo Sapien

<400>  262
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgataatat tggttctaag tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatggtgat tctaatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg cactcgtact tctactccta tttctggtgt gtttggcggc      300

ggcacgaagt taaccgttct tggccagccg aaagccgcac cgagtgtgac gctgtttccg      360

ccgagcagcg aagaattgca ggcgaacaaa gcgaccctgg tgtgcctgat tagcgacttt      420

tatccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgagggg      600

agcaccgtgg aaaaaaccgt tgcgccgact gaggcctgc                             639


<210>  263
<211>  222
<212>  PRT
<213>  Homo Sapien

<400>  263

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Asn 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Asp Gly Met Gly His Thr Tyr Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Tyr Asp Tyr Ile Lys Tyr Gly Ala Phe Asp Pro Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             


Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 


Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 


Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     


Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         


Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             


Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 
    210                 215                 220         


<210>  264
<211>  666
<212>  DNA
<213>  Homo Sapien

<400>  264
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct gttaatggta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcgtt attgatggta tgggtcatac ttattatgct      180

gattctgtta agggtcgttt taccatttca cgtgataatt cgaaaaacac cctgtatctg      240

caaatgaaca gcctgcgtgc ggaagatacg gccgtgtatt attgcgcgcg ttatgattat      300

attaagtatg gtgcttttga tccttggggc caaggcaccc tggtgacggt tagctcagcg      360

tcgaccaaag gtccaagcgt gtttccgctg gctccgagca gcaaaagcac cagcggcggc      420

acggctgccc tgggctgcct ggttaaagat tatttcccgg aaccagtcac cgtgagctgg      480

aacagcgggg cgctgaccag cggcgtgcat acctttccgg cggtgctgca aagcagcggc      540

ctgtatagcc tgagcagcgt tgtgaccgtg ccgagcagca gcttaggcac tcagacctat      600

atttgcaacg tgaaccataa accgagcaac accaaagtgg ataaaaaagt ggaaccgaaa      660

agctgc                                                                 666


<210>  265
<211>  1105
<212>  PRT
<213>  Homo Sapien

<400>  265

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Ile Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ser Asp Ala His Lys 
                245                 250                 255     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            260                 265                 270         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe 
        275                 280                 285             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    290                 295                 300                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
305                 310                 315                 320 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                325                 330                 335     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            340                 345                 350         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        355                 360                 365             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    370                 375                 380                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
385                 390                 395                 400 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                405                 410                 415     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            420                 425                 430         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        435                 440                 445             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    450                 455                 460                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
465                 470                 475                 480 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                485                 490                 495     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            500                 505                 510         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        515                 520                 525             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    530                 535                 540                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
545                 550                 555                 560 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                565                 570                 575     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            580                 585                 590         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        595                 600                 605             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    610                 615                 620                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
625                 630                 635                 640 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                645                 650                 655     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            660                 665                 670         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        675                 680                 685             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    690                 695                 700                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
705                 710                 715                 720 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                725                 730                 735     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            740                 745                 750         


Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        755                 760                 765             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    770                 775                 780                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
785                 790                 795                 800 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                805                 810                 815     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            820                 825                 830         


Ala Ala Leu Gly Leu Ala Ala Ala Leu Asp Ile Val Leu Thr Gln Ser 
        835                 840                 845             


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
    850                 855                 860                 


Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln 
865                 870                 875                 880 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg 
                885                 890                 895     


Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            900                 905                 910         


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr 
        915                 920                 925             


Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr 
    930                 935                 940                 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser 
                965                 970                 975     


Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr 
            980                 985                 990         


Phe Ser Gly Phe Ser Leu Ser Asn  Arg Gly Gly Gly Val  Gly Trp Ile 
        995                 1000                 1005             


Arg Gln  Pro Pro Gly Lys Ala  Leu Glu Trp Leu Ala  Trp Ile Asp 
    1010                 1015                 1020             


Trp Asp  Asp Asp Lys Ser Tyr  Ser Thr Ser Leu Lys  Thr Arg Leu 
    1025                 1030                 1035             


Thr Ile  Ser Lys Asp Thr Ser  Lys Asn Gln Val Val  Leu Thr Met 
    1040                 1045                 1050             


Thr Asn  Met Asp Pro Val Asp  Thr Ala Thr Tyr Tyr  Cys Ala Arg 
    1055                 1060                 1065             


Met His  Leu Pro Leu Val Phe  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1070                 1075                 1080             


Val Thr  Val Ser Ser Ala Ala  Ala Glu Asn Leu Tyr  Phe Gln Gly 
    1085                 1090                 1095             


Ser His  His His His His His  
    1100                 1105 


<210>  266
<211>  3315
<212>  DNA
<213>  Homo Sapien

<400>  266
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga ttaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttagcggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctggcg gcgagcgacg ctcacaagag cgaagtggca      780

cataggttca aagatctggg cgaagagaac tttaaggccc tcgtcctgat cgctttcgca      840

cagtacctcc agcagtctcc ctttgaagat cacgtgaaac tggtcaatga ggtgaccgaa      900

tttgccaaga catgcgtggc tgatgagagt gcagaaaact gtgacaaatc actgcatact      960

ctctttggag ataagctgtg caccgtcgcc acactcagag agacttatgg ggaaatggct     1020

gactgttgcg caaaacagga gcctgaacgg aatgagtgtt tcctccagca caaggatgac     1080

aacccaaatc tgccccgcct cgtgcgacct gaggtcgatg tgatgtgcac cgcctttcat     1140

gacaacgaag agacattcct gaagaaatac ctgtatgaaa ttgctcgtag gcacccatac     1200

ttttatgccc ccgagctcct gttctttgca aagagataca aagctgcctt cactgaatgt     1260

tgccaggcag ctgataaggc cgcatgtctc ctgcctaaac tggacgagct ccgggatgaa     1320

ggtaaggctt ccagcgccaa acagcgcctg aagtgcgctt ctctccagaa gtttggcgag     1380

cgagcattca aagcctgggc tgtggcccgt ctcagtcaga ggtttccaaa ggcagaattt     1440

gctgaggtct caaaactggt gaccgacctc acaaaggtcc atactgagtg ttgccacgga     1500

gatctgctgg aatgtgccga cgatagagca gacctcgcta aatatatctg cgagaatcag     1560

gattccatta gctctaagct gaaagaatgt tgcgagaagc ccctcctgga aaagagtcat     1620

tgtatcgccg aggtggaaaa cgacgagatg ccagcagatc tgccatcact cgctgccgac     1680

tttgtggaat ccaaagatgt ctgcaagaat tacgcagagg ctaaagacgt gttcctgggg     1740

atgtttctgt atgagtacgc ccggcgtcac cccgattata gcgtcgtgct cctgctccga     1800

ctggcaaaga cctacgaaac aactctggag aaatgttgcg ctgccgcaga ccctcatgaa     1860

tgttatgcta aggtgttcga tgagtttaag ccactcgtcg aagagcccca gaacctgatt     1920

aaacagaatt gcgaactgtt cgagcagctc ggtgaataca agtttcagaa cgccctgctc     1980

gtgcgttata ccaaaaaggt ccctcaggtg tctacaccaa ctctggtgga ggtcagtagg     2040

aatctgggca aagtgggatc aaagtgttgc aaacaccccg aggcaaagag aatgccttgt     2100

gctgaagatt acctctccgt cgtgctgaac cagctctgcg tgctgcatga aaagacccca     2160

gtcagcgatc gggtgacaaa atgttgcacc gaatctctgg tcaatcgccg accctgtttc     2220

agtgccctcg aagtggacga aacttatgtg cctaaggagt ttcaggctga aacattcacc     2280

tttcacgccg atatctgcac tctgtccgag aaagaaaggc agattaagaa acagacagca     2340

ctggtcgagc tcgtgaagca taaaccaaag gctaccaagg agcagctgaa agccgtcatg     2400

gacgatttcg cagcttttgt ggaaaagtgt tgcaaagccg acgataagga gacttgtttc     2460

gcagaagagg ggaaaaagct cgtggctgcc agccaggcag ctctgggtct ggcggcggcg     2520

ctggatatcg tgctgacaca gagccctgcc accctgtctc tgagccctgg cgagagagcc     2580

accctgagct gccgggccag ccagttcatc ggctcccgct acctggcctg gtatcagcag     2640

aagcccggac aggctcccag actgctgatc tacggcgcca gcaacagagc taccggcgtg     2700

cccgccagat tttctggcag cggcagcggc accgacttca ccctgaccat cagcagcctg     2760

gaacccgagg acttcgccac ctactactgc cagcagtact acgactaccc ccagaccttc     2820

ggccagggca ccaaggtgga gatcaagggc ggaggcggaa gcgggggtgg cggaagtgga     2880

ggcggaggaa gcggaggggg cggaagccag gtgcaattga aagagtccgg ccctgccctg     2940

gtgaagccta cccagaccct gaccctgaca tgcaccttca gcggcttcag cctgagcaac     3000

agaggcggcg gagtgggctg gatcagacag cctcccggca aggccctgga atggctggcc     3060

tggatcgact gggacgacga caagagctac agcaccagcc tgaaaacccg gctgaccatc     3120

tccaaggaca ccagcaagaa ccaggtggtg ctcaccatga ccaacatgga ccccgtggac     3180

accgccacct attattgcgc ccggatgcat ctgcccctgg tgttcgatag ctggggccag     3240

ggaaccctgg tgacagtgtc cagcgcggcc gcagagaacc tgtattttca gggtagccac     3300

catcatcacc atcac                                                      3315


<210>  267
<211>  1105
<212>  PRT
<213>  Homo Sapien

<400>  267

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ser Asp Ala His Lys 
                245                 250                 255     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            260                 265                 270         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe 
        275                 280                 285             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    290                 295                 300                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
305                 310                 315                 320 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                325                 330                 335     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            340                 345                 350         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        355                 360                 365             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    370                 375                 380                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
385                 390                 395                 400 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                405                 410                 415     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            420                 425                 430         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        435                 440                 445             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    450                 455                 460                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
465                 470                 475                 480 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                485                 490                 495     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            500                 505                 510         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        515                 520                 525             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    530                 535                 540                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
545                 550                 555                 560 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                565                 570                 575     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            580                 585                 590         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        595                 600                 605             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    610                 615                 620                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
625                 630                 635                 640 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                645                 650                 655     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            660                 665                 670         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        675                 680                 685             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    690                 695                 700                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
705                 710                 715                 720 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                725                 730                 735     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            740                 745                 750         


Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        755                 760                 765             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    770                 775                 780                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
785                 790                 795                 800 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                805                 810                 815     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            820                 825                 830         


Ala Ala Leu Gly Leu Ala Ala Ala Leu Asp Ile Val Leu Thr Gln Ser 
        835                 840                 845             


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
    850                 855                 860                 


Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln 
865                 870                 875                 880 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg 
                885                 890                 895     


Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            900                 905                 910         


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr 
        915                 920                 925             


Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr 
    930                 935                 940                 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser 
                965                 970                 975     


Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr 
            980                 985                 990         


Phe Ser Gly Phe Ser Leu Ser Asn  Arg Gly Gly Gly Val  Gly Trp Ile 
        995                 1000                 1005             


Arg Gln  Pro Pro Gly Lys Ala  Leu Glu Trp Leu Ala  Trp Ile Asp 
    1010                 1015                 1020             


Trp Asp  Asp Asp Lys Ser Tyr  Ser Thr Ser Leu Lys  Thr Arg Leu 
    1025                 1030                 1035             


Thr Ile  Ser Lys Asp Thr Ser  Lys Asn Gln Val Val  Leu Thr Met 
    1040                 1045                 1050             


Thr Asn  Met Asp Pro Val Asp  Thr Ala Thr Tyr Tyr  Cys Ala Arg 
    1055                 1060                 1065             


Phe His  Leu Pro Leu Val Phe  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1070                 1075                 1080             


Val Thr  Val Ser Ser Ala Ala  Ala Glu Asn Leu Tyr  Phe Gln Gly 
    1085                 1090                 1095             


Ser His  His His His His His  
    1100                 1105 


<210>  268
<211>  3315
<212>  DNA
<213>  Homo Sapien

<400>  268
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctggcg gcgagcgacg ctcacaagag cgaagtggca      780

cataggttca aagatctggg cgaagagaac tttaaggccc tcgtcctgat cgctttcgca      840

cagtacctcc agcagtctcc ctttgaagat cacgtgaaac tggtcaatga ggtgaccgaa      900

tttgccaaga catgcgtggc tgatgagagt gcagaaaact gtgacaaatc actgcatact      960

ctctttggag ataagctgtg caccgtcgcc acactcagag agacttatgg ggaaatggct     1020

gactgttgcg caaaacagga gcctgaacgg aatgagtgtt tcctccagca caaggatgac     1080

aacccaaatc tgccccgcct cgtgcgacct gaggtcgatg tgatgtgcac cgcctttcat     1140

gacaacgaag agacattcct gaagaaatac ctgtatgaaa ttgctcgtag gcacccatac     1200

ttttatgccc ccgagctcct gttctttgca aagagataca aagctgcctt cactgaatgt     1260

tgccaggcag ctgataaggc cgcatgtctc ctgcctaaac tggacgagct ccgggatgaa     1320

ggtaaggctt ccagcgccaa acagcgcctg aagtgcgctt ctctccagaa gtttggcgag     1380

cgagcattca aagcctgggc tgtggcccgt ctcagtcaga ggtttccaaa ggcagaattt     1440

gctgaggtct caaaactggt gaccgacctc acaaaggtcc atactgagtg ttgccacgga     1500

gatctgctgg aatgtgccga cgatagagca gacctcgcta aatatatctg cgagaatcag     1560

gattccatta gctctaagct gaaagaatgt tgcgagaagc ccctcctgga aaagagtcat     1620

tgtatcgccg aggtggaaaa cgacgagatg ccagcagatc tgccatcact cgctgccgac     1680

tttgtggaat ccaaagatgt ctgcaagaat tacgcagagg ctaaagacgt gttcctgggg     1740

atgtttctgt atgagtacgc ccggcgtcac cccgattata gcgtcgtgct cctgctccga     1800

ctggcaaaga cctacgaaac aactctggag aaatgttgcg ctgccgcaga ccctcatgaa     1860

tgttatgcta aggtgttcga tgagtttaag ccactcgtcg aagagcccca gaacctgatt     1920

aaacagaatt gcgaactgtt cgagcagctc ggtgaataca agtttcagaa cgccctgctc     1980

gtgcgttata ccaaaaaggt ccctcaggtg tctacaccaa ctctggtgga ggtcagtagg     2040

aatctgggca aagtgggatc aaagtgttgc aaacaccccg aggcaaagag aatgccttgt     2100

gctgaagatt acctctccgt cgtgctgaac cagctctgcg tgctgcatga aaagacccca     2160

gtcagcgatc gggtgacaaa atgttgcacc gaatctctgg tcaatcgccg accctgtttc     2220

agtgccctcg aagtggacga aacttatgtg cctaaggagt ttcaggctga aacattcacc     2280

tttcacgccg atatctgcac tctgtccgag aaagaaaggc agattaagaa acagacagca     2340

ctggtcgagc tcgtgaagca taaaccaaag gctaccaagg agcagctgaa agccgtcatg     2400

gacgatttcg cagcttttgt ggaaaagtgt tgcaaagccg acgataagga gacttgtttc     2460

gcagaagagg ggaaaaagct cgtggctgcc agccaggcag ctctgggtct ggcggcggcg     2520

ctggatatcg tgctgacaca gagccctgcc accctgtctc tgagccctgg cgagagagcc     2580

accctgagct gccgggccag ccagttcatc ggctcccgct acctggcctg gtatcagcag     2640

aagcccggac aggctcccag actgctgatc tacggcgcca gcaacagagc taccggcgtg     2700

cccgccagat tttctggcag cggcagcggc accgacttca ccctgaccat cagcagcctg     2760

gaacccgagg acttcgccac ctactactgc cagcagtact acgactaccc ccagaccttc     2820

ggccagggca ccaaggtgga gatcaagggc ggaggcggaa gcgggggtgg cggaagtgga     2880

ggcggaggaa gcggaggggg cggaagccag gtgcaattga aagagtccgg ccctgccctg     2940

gtgaagccta cccagaccct gaccctgaca tgcaccttca gcggcttcag cctgagcaac     3000

agaggcggcg gagtgggctg gatcagacag cctcccggca aggccctgga atggctggcc     3060

tggatcgact gggacgacga caagagctac agcaccagcc tgaaaacccg gctgaccatc     3120

tccaaggaca ccagcaagaa ccaggtggtg ctcaccatga ccaacatgga ccccgtggac     3180

accgccacct attattgcgc ccggtttcat ctgcccctgg tgttcgatag ctggggccag     3240

ggaaccctgg tgacagtgtc cagcgcggcc gcagagaacc tgtattttca gggtagccac     3300

catcatcacc atcac                                                      3315


<210>  269
<211>  1105
<212>  PRT
<213>  Homo Sapien

<400>  269

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Met His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Ser Asp Ala His Lys Ser Glu 
                245                 250                 255     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            260                 265                 270         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp 
        275                 280                 285             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    290                 295                 300                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
305                 310                 315                 320 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                325                 330                 335     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            340                 345                 350         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        355                 360                 365             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    370                 375                 380                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                405                 410                 415     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            420                 425                 430         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        435                 440                 445             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    450                 455                 460                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
465                 470                 475                 480 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                485                 490                 495     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            500                 505                 510         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        515                 520                 525             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    530                 535                 540                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
545                 550                 555                 560 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                565                 570                 575     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            580                 585                 590         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        595                 600                 605             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    610                 615                 620                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
625                 630                 635                 640 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                645                 650                 655     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            660                 665                 670         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        675                 680                 685             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    690                 695                 700                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
705                 710                 715                 720 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                725                 730                 735     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            740                 745                 750         


Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        755                 760                 765             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    770                 775                 780                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
785                 790                 795                 800 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                805                 810                 815     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            820                 825                 830         


Leu Gly Leu Ala Ala Ala Leu Gln Val Gln Leu Val Glu Ser Gly Gly 
        835                 840                 845             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    850                 855                 860                 


Gly Phe Thr Phe Ser Asp Tyr Val Ile Asn Trp Val Arg Gln Ala Pro 
865                 870                 875                 880 


Gly Lys Gly Leu Glu Trp Val Ser Gly Ile Ser Trp Ser Gly Val Asn 
                885                 890                 895     


Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            900                 905                 910         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        915                 920                 925             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn 
    930                 935                 940                 


Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
945                 950                 955                 960 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser 
            980                 985                 990         


Val Ser Val Ala Pro Gly Gln Thr  Ala Arg Ile Ser Cys  Ser Gly Asp 
        995                 1000                 1005             


Ser Leu  Arg Asn Lys Val Tyr  Trp Tyr Gln Gln Lys  Pro Gly Gln 
    1010                 1015                 1020             


Ala Pro  Val Leu Val Ile Tyr  Lys Asn Asn Arg Pro  Ser Gly Ile 
    1025                 1030                 1035             


Pro Glu  Arg Phe Ser Gly Ser  Asn Ser Gly Asn Thr  Ala Thr Leu 
    1040                 1045                 1050             


Thr Ile  Ser Gly Thr Gln Ala  Glu Asp Glu Ala Asp  Tyr Tyr Cys 
    1055                 1060                 1065             


Gln Ser  Tyr Asp Gly Gln Lys  Ser Leu Val Phe Gly  Gly Gly Thr 
    1070                 1075                 1080             


Lys Leu  Thr Val Leu Ala Ala  Ala Glu Asn Leu Tyr  Phe Gln Gly 
    1085                 1090                 1095             


Ser His  His His His His His  
    1100                 1105 


<210>  270
<211>  3315
<212>  DNA
<213>  Homo Sapien

<400>  270
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gatgcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgcggcgagc gacgctcaca agagcgaagt ggcacatagg      780

ttcaaagatc tgggcgaaga gaactttaag gccctcgtcc tgatcgcttt cgcacagtac      840

ctccagcagt ctccctttga agatcacgtg aaactggtca atgaggtgac cgaatttgcc      900

aagacatgcg tggctgatga gagtgcagaa aactgtgaca aatcactgca tactctcttt      960

ggagataagc tgtgcaccgt cgccacactc agagagactt atggggaaat ggctgactgt     1020

tgcgcaaaac aggagcctga acggaatgag tgtttcctcc agcacaagga tgacaaccca     1080

aatctgcccc gcctcgtgcg acctgaggtc gatgtgatgt gcaccgcctt tcatgacaac     1140

gaagagacat tcctgaagaa atacctgtat gaaattgctc gtaggcaccc atacttttat     1200

gcccccgagc tcctgttctt tgcaaagaga tacaaagctg ccttcactga atgttgccag     1260

gcagctgata aggccgcatg tctcctgcct aaactggacg agctccggga tgaaggtaag     1320

gcttccagcg ccaaacagcg cctgaagtgc gcttctctcc agaagtttgg cgagcgagca     1380

ttcaaagcct gggctgtggc ccgtctcagt cagaggtttc caaaggcaga atttgctgag     1440

gtctcaaaac tggtgaccga cctcacaaag gtccatactg agtgttgcca cggagatctg     1500

ctggaatgtg ccgacgatag agcagacctc gctaaatata tctgcgagaa tcaggattcc     1560

attagctcta agctgaaaga atgttgcgag aagcccctcc tggaaaagag tcattgtatc     1620

gccgaggtgg aaaacgacga gatgccagca gatctgccat cactcgctgc cgactttgtg     1680

gaatccaaag atgtctgcaa gaattacgca gaggctaaag acgtgttcct ggggatgttt     1740

ctgtatgagt acgcccggcg tcaccccgat tatagcgtcg tgctcctgct ccgactggca     1800

aagacctacg aaacaactct ggagaaatgt tgcgctgccg cagaccctca tgaatgttat     1860

gctaaggtgt tcgatgagtt taagccactc gtcgaagagc cccagaacct gattaaacag     1920

aattgcgaac tgttcgagca gctcggtgaa tacaagtttc agaacgccct gctcgtgcgt     1980

tataccaaaa aggtccctca ggtgtctaca ccaactctgg tggaggtcag taggaatctg     2040

ggcaaagtgg gatcaaagtg ttgcaaacac cccgaggcaa agagaatgcc ttgtgctgaa     2100

gattacctct ccgtcgtgct gaaccagctc tgcgtgctgc atgaaaagac cccagtcagc     2160

gatcgggtga caaaatgttg caccgaatct ctggtcaatc gccgaccctg tttcagtgcc     2220

ctcgaagtgg acgaaactta tgtgcctaag gagtttcagg ctgaaacatt cacctttcac     2280

gccgatatct gcactctgtc cgagaaagaa aggcagatta agaaacagac agcactggtc     2340

gagctcgtga agcataaacc aaaggctacc aaggagcagc tgaaagccgt catggacgat     2400

ttcgcagctt ttgtggaaaa gtgttgcaaa gccgacgata aggagacttg tttcgcagaa     2460

gaggggaaaa agctcgtggc tgccagccag gcagctctgg gtctggcggc ggcgctgcag     2520

gttcaattgg ttgaaagcgg tggtggtctg gttcagcctg gtggtagcct gcgtctgagc     2580

tgtgcagcaa gcggttttac ctttagcgat tatgtgatta attgggttcg tcaggcaccg     2640

ggtaaaggtc tggaatgggt tagcggtatt agctggtcag gtgttaatac ccattatgca     2700

gatagcgtga aaggtcgttt taccattagc cgtgataata gcaaaaatac cctgtatctg     2760

cagatgaata gcctgcgtgc agaagatacc gcagtttatt attgtgcacg tctgggtgca     2820

accgcaaata atattcgcta taaatttatg gatgtgtggg gtcagggtac actagttacc     2880

gttagcagtg gtggtggcgg cagcggcggt ggcggttccg gcggtggtgg cagcggtggt     2940

ggtggtagcg atatcgaact gacccagcct ccgagcgtta gcgttgcacc gggtcagacc     3000

gcacgtatta gctgtagcgg tgatagtctg cgtaataaag tttattggta tcagcagaaa     3060

ccgggtcagg ctccggttct ggttatttat aaaaataatc gtccgagcgg tattccggaa     3120

cgttttagcg gtagcaatag cggtaatacc gcaaccctga ccattagcgg cacccaggca     3180

gaagatgaag ccgattatta ttgtcagagc tatgatggtc agaaaagcct ggtttttggt     3240

ggtggcacca agcttaccgt tctggcggcc gcagagaacc tgtattttca gggtagccac     3300

catcatcacc atcac                                                      3315


<210>  271
<211>  1105
<212>  PRT
<213>  Homo Sapien

<400>  271

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Ser Asp Ala His Lys Ser Glu 
                245                 250                 255     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            260                 265                 270         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp 
        275                 280                 285             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    290                 295                 300                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
305                 310                 315                 320 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                325                 330                 335     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            340                 345                 350         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        355                 360                 365             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    370                 375                 380                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                405                 410                 415     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            420                 425                 430         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        435                 440                 445             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    450                 455                 460                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
465                 470                 475                 480 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                485                 490                 495     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            500                 505                 510         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        515                 520                 525             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    530                 535                 540                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
545                 550                 555                 560 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                565                 570                 575     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            580                 585                 590         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        595                 600                 605             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    610                 615                 620                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
625                 630                 635                 640 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                645                 650                 655     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            660                 665                 670         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        675                 680                 685             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    690                 695                 700                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
705                 710                 715                 720 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                725                 730                 735     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            740                 745                 750         


Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        755                 760                 765             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    770                 775                 780                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
785                 790                 795                 800 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                805                 810                 815     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            820                 825                 830         


Leu Gly Leu Ala Ala Ala Leu Gln Val Gln Leu Val Glu Ser Gly Gly 
        835                 840                 845             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    850                 855                 860                 


Gly Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln Ala Pro 
865                 870                 875                 880 


Gly Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly Val Asn 
                885                 890                 895     


Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            900                 905                 910         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        915                 920                 925             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn 
    930                 935                 940                 


Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
945                 950                 955                 960 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser 
            980                 985                 990         


Val Ser Val Ala Pro Gly Gln Thr  Ala Arg Ile Ser Cys  Ser Gly Asp 
        995                 1000                 1005             


Ser Leu  Arg Asn Lys Val Tyr  Trp Tyr Gln Gln Lys  Pro Gly Gln 
    1010                 1015                 1020             


Ala Pro  Val Leu Val Ile Tyr  Lys Asn Asn Arg Pro  Ser Gly Ile 
    1025                 1030                 1035             


Pro Glu  Arg Phe Ser Gly Ser  Asn Ser Gly Asn Thr  Ala Thr Leu 
    1040                 1045                 1050             


Thr Ile  Ser Gly Thr Gln Ala  Glu Asp Glu Ala Asp  Tyr Tyr Cys 
    1055                 1060                 1065             


Gln Ser  Tyr Asp Gly Gln Lys  Ser Leu Val Phe Gly  Gly Gly Thr 
    1070                 1075                 1080             


Lys Leu  Thr Val Leu Ala Ala  Ala Glu Asn Leu Tyr  Phe Gln Gly 
    1085                 1090                 1095             


Ser His  His His His His His  
    1100                 1105 


<210>  272
<211>  3315
<212>  DNA
<213>  Homo Sapien

<400>  272
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgcggcgagc gacgctcaca agagcgaagt ggcacatagg      780

ttcaaagatc tgggcgaaga gaactttaag gccctcgtcc tgatcgcttt cgcacagtac      840

ctccagcagt ctccctttga agatcacgtg aaactggtca atgaggtgac cgaatttgcc      900

aagacatgcg tggctgatga gagtgcagaa aactgtgaca aatcactgca tactctcttt      960

ggagataagc tgtgcaccgt cgccacactc agagagactt atggggaaat ggctgactgt     1020

tgcgcaaaac aggagcctga acggaatgag tgtttcctcc agcacaagga tgacaaccca     1080

aatctgcccc gcctcgtgcg acctgaggtc gatgtgatgt gcaccgcctt tcatgacaac     1140

gaagagacat tcctgaagaa atacctgtat gaaattgctc gtaggcaccc atacttttat     1200

gcccccgagc tcctgttctt tgcaaagaga tacaaagctg ccttcactga atgttgccag     1260

gcagctgata aggccgcatg tctcctgcct aaactggacg agctccggga tgaaggtaag     1320

gcttccagcg ccaaacagcg cctgaagtgc gcttctctcc agaagtttgg cgagcgagca     1380

ttcaaagcct gggctgtggc ccgtctcagt cagaggtttc caaaggcaga atttgctgag     1440

gtctcaaaac tggtgaccga cctcacaaag gtccatactg agtgttgcca cggagatctg     1500

ctggaatgtg ccgacgatag agcagacctc gctaaatata tctgcgagaa tcaggattcc     1560

attagctcta agctgaaaga atgttgcgag aagcccctcc tggaaaagag tcattgtatc     1620

gccgaggtgg aaaacgacga gatgccagca gatctgccat cactcgctgc cgactttgtg     1680

gaatccaaag atgtctgcaa gaattacgca gaggctaaag acgtgttcct ggggatgttt     1740

ctgtatgagt acgcccggcg tcaccccgat tatagcgtcg tgctcctgct ccgactggca     1800

aagacctacg aaacaactct ggagaaatgt tgcgctgccg cagaccctca tgaatgttat     1860

gctaaggtgt tcgatgagtt taagccactc gtcgaagagc cccagaacct gattaaacag     1920

aattgcgaac tgttcgagca gctcggtgaa tacaagtttc agaacgccct gctcgtgcgt     1980

tataccaaaa aggtccctca ggtgtctaca ccaactctgg tggaggtcag taggaatctg     2040

ggcaaagtgg gatcaaagtg ttgcaaacac cccgaggcaa agagaatgcc ttgtgctgaa     2100

gattacctct ccgtcgtgct gaaccagctc tgcgtgctgc atgaaaagac cccagtcagc     2160

gatcgggtga caaaatgttg caccgaatct ctggtcaatc gccgaccctg tttcagtgcc     2220

ctcgaagtgg acgaaactta tgtgcctaag gagtttcagg ctgaaacatt cacctttcac     2280

gccgatatct gcactctgtc cgagaaagaa aggcagatta agaaacagac agcactggtc     2340

gagctcgtga agcataaacc aaaggctacc aaggagcagc tgaaagccgt catggacgat     2400

ttcgcagctt ttgtggaaaa gtgttgcaaa gccgacgata aggagacttg tttcgcagaa     2460

gaggggaaaa agctcgtggc tgccagccag gcagctctgg gtctggcggc ggcgctgcag     2520

gttcaattgg ttgaaagcgg tggtggtctg gttcagcctg gtggtagcct gcgtctgagc     2580

tgtgcagcaa gcggttttac ctttagcgat tatgtgatga attgggttcg tcaggcaccg     2640

ggtaaaggtc tggaatgggt tgccggtatt agctggtcag gtgttaatac ccattatgca     2700

gatagcgtga aaggtcgttt taccattagc cgtgataata gcaaaaatac cctgtatctg     2760

cagatgaata gcctgcgtgc agaagatacc gcagtttatt attgtgcacg tctgggtgca     2820

accgcaaata atattcgcta taaatttatg gatgtgtggg gtcagggtac actagttacc     2880

gttagcagtg gtggtggcgg cagcggcggt ggcggttccg gcggtggtgg cagcggtggt     2940

ggtggtagcg atatcgaact gacccagcct ccgagcgtta gcgttgcacc gggtcagacc     3000

gcacgtatta gctgtagcgg tgatagtctg cgtaataaag tttattggta tcagcagaaa     3060

ccgggtcagg ctccggttct ggttatttat aaaaataatc gtccgagcgg tattccggaa     3120

cgttttagcg gtagcaatag cggtaatacc gcaaccctga ccattagcgg cacccaggca     3180

gaagatgaag ccgattatta ttgtcagagc tatgatggtc agaaaagcct ggtttttggt     3240

ggtggcacca agcttaccgt tctggcggcc gcagagaacc tgtattttca gggtagccac     3300

catcatcacc atcac                                                      3315


<210>  273
<211>  1120
<212>  PRT
<213>  Homo Sapien

<400>  273

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gly Gly Gly Ser Gly Gly 
                245                 250                 255     


Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
            260                 265                 270         


Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln 
        275                 280                 285             


Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu 
    290                 295                 300                 


Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys 
305                 310                 315                 320 


Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu 
                325                 330                 335     


Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro 
            340                 345                 350         


Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu 
        355                 360                 365             


Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His 
    370                 375                 380                 


Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg 
385                 390                 395                 400 


Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg 
                405                 410                 415     


Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala 
            420                 425                 430         


Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser 
        435                 440                 445             


Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu 
    450                 455                 460                 


Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro 
465                 470                 475                 480 


Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys 
                485                 490                 495     


Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp 
            500                 505                 510         


Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 
        515                 520                 525             


Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His 
    530                 535                 540                 


Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser 
545                 550                 555                 560 


Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala 
                565                 570                 575     


Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg 
            580                 585                 590         


Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr 
        595                 600                 605             


Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu 
    610                 615                 620                 


Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro 
625                 630                 635                 640 


Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu 
                645                 650                 655     


Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro 
            660                 665                 670         


Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys 
        675                 680                 685             


Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys 
    690                 695                 700                 


Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His 
705                 710                 715                 720 


Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser 
                725                 730                 735     


Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr 
            740                 745                 750         


Tyr Val Pro Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp 
        755                 760                 765             


Ile Cys Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala 
    770                 775                 780                 


Leu Val Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu 
785                 790                 795                 800 


Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys 
                805                 810                 815     


Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val 
            820                 825                 830         


Ala Ala Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly 
        835                 840                 845             


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr Gln Ser Pro 
    850                 855                 860                 


Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg 
865                 870                 875                 880 


Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys 
                885                 890                 895     


Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala 
            900                 905                 910         


Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
        915                 920                 925             


Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr 
    930                 935                 940                 


Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr Lys 
945                 950                 955                 960 


Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser Gly 
            980                 985                 990         


Pro Ala Leu Val Lys Pro Thr Gln  Thr Leu Thr Leu Thr  Cys Thr Phe 
        995                 1000                 1005             


Ser Gly  Phe Ser Leu Ser Asn  Arg Gly Gly Gly Val  Gly Trp Ile 
    1010                 1015                 1020             


Arg Gln  Pro Pro Gly Lys Ala  Leu Glu Trp Leu Ala  Trp Ile Asp 
    1025                 1030                 1035             


Trp Asp  Asp Asp Lys Ser Tyr  Ser Thr Ser Leu Lys  Thr Arg Leu 
    1040                 1045                 1050             


Thr Ile  Ser Lys Asp Thr Ser  Lys Asn Gln Val Val  Leu Thr Met 
    1055                 1060                 1065             


Thr Asn  Met Asp Pro Val Asp  Thr Ala Thr Tyr Tyr  Cys Ala Arg 
    1070                 1075                 1080             


Phe His  Leu Pro Leu Val Phe  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1085                 1090                 1095             


Val Thr  Val Ser Ser Ala Ala  Ala Glu Asn Leu Tyr  Phe Gln Gly 
    1100                 1105                 1110             


Ser His  His His His His His  
    1115                 1120 


<210>  274
<211>  3360
<212>  DNA
<213>  Homo Sapien

<400>  274
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctgggg ggtggcggaa gtgggggtga cgctcacaag      780

agcgaagtgg cacataggtt caaagatctg ggcgaagaga actttaaggc cctcgtcctg      840

atcgctttcg cacagtacct ccagcagtct ccctttgaag atcacgtgaa actggtcaat      900

gaggtgaccg aatttgccaa gacatgcgtg gctgatgaga gtgcagaaaa ctgtgacaaa      960

tcactgcata ctctctttgg agataagctg tgcaccgtcg ccacactcag agagacttat     1020

ggggaaatgg ctgactgttg cgcaaaacag gagcctgaac ggaatgagtg tttcctccag     1080

cacaaggatg acaacccaaa tctgccccgc ctcgtgcgac ctgaggtcga tgtgatgtgc     1140

accgcctttc atgacaacga agagacattc ctgaagaaat acctgtatga aattgctcgt     1200

aggcacccat acttttatgc ccccgagctc ctgttctttg caaagagata caaagctgcc     1260

ttcactgaat gttgccaggc agctgataag gccgcatgtc tcctgcctaa actggacgag     1320

ctccgggatg aaggtaaggc ttccagcgcc aaacagcgcc tgaagtgcgc ttctctccag     1380

aagtttggcg agcgagcatt caaagcctgg gctgtggccc gtctcagtca gaggtttcca     1440

aaggcagaat ttgctgaggt ctcaaaactg gtgaccgacc tcacaaaggt ccatactgag     1500

tgttgccacg gagatctgct ggaatgtgcc gacgatagag cagacctcgc taaatatatc     1560

tgcgagaatc aggattccat tagctctaag ctgaaagaat gttgcgagaa gcccctcctg     1620

gaaaagagtc attgtatcgc cgaggtggaa aacgacgaga tgccagcaga tctgccatca     1680

ctcgctgccg actttgtgga atccaaagat gtctgcaaga attacgcaga ggctaaagac     1740

gtgttcctgg ggatgtttct gtatgagtac gcccggcgtc accccgatta tagcgtcgtg     1800

ctcctgctcc gactggcaaa gacctacgaa acaactctgg agaaatgttg cgctgccgca     1860

gaccctcatg aatgttatgc taaggtgttc gatgagttta agccactcgt cgaagagccc     1920

cagaacctga ttaaacagaa ttgcgaactg ttcgagcagc tcggtgaata caagtttcag     1980

aacgccctgc tcgtgcgtta taccaaaaag gtccctcagg tgtctacacc aactctggtg     2040

gaggtcagta ggaatctggg caaagtggga tcaaagtgtt gcaaacaccc cgaggcaaag     2100

agaatgcctt gtgctgaaga ttacctctcc gtcgtgctga accagctctg cgtgctgcat     2160

gaaaagaccc cagtcagcga tcgggtgaca aaatgttgca ccgaatctct ggtcaatcgc     2220

cgaccctgtt tcagtgccct cgaagtggac gaaacttatg tgcctaagga gtttcaggct     2280

gaaacattca cctttcacgc cgatatctgc actctgtccg agaaagaaag gcagattaag     2340

aaacagacag cactggtcga gctcgtgaag cataaaccaa aggctaccaa ggagcagctg     2400

aaagccgtca tggacgattt cgcagctttt gtggaaaagt gttgcaaagc cgacgataag     2460

gagacttgtt tcgcagaaga ggggaaaaag ctcgtggctg ccagccaggc agctctgggt     2520

ctggggggtg gcggaagtgg gggtggcgga agtgggggtg gcggaagtga tatcgtgctg     2580

acacagagcc ctgccaccct gtctctgagc cctggcgaga gagccaccct gagctgccgg     2640

gccagccagt tcatcggctc ccgctacctg gcctggtatc agcagaagcc cggacaggct     2700

cccagactgc tgatctacgg cgccagcaac agagctaccg gcgtgcccgc cagattttct     2760

ggcagcggca gcggcaccga cttcaccctg accatcagca gcctggaacc cgaggacttc     2820

gccacctact actgccagca gtactacgac tacccccaga ccttcggcca gggcaccaag     2880

gtggagatca agggcggagg cggaagcggg ggtggcggaa gtggaggcgg aggaagcgga     2940

gggggcggaa gccaggtgca attgaaagag tccggccctg ccctggtgaa gcctacccag     3000

accctgaccc tgacatgcac cttcagcggc ttcagcctga gcaacagagg cggcggagtg     3060

ggctggatca gacagcctcc cggcaaggcc ctggaatggc tggcctggat cgactgggac     3120

gacgacaaga gctacagcac cagcctgaaa acccggctga ccatctccaa ggacaccagc     3180

aagaaccagg tggtgctcac catgaccaac atggaccccg tggacaccgc cacctattat     3240

tgcgcccggt ttcatctgcc cctggtgttc gatagctggg gccagggaac cctggtgaca     3300

gtgtccagcg cggccgcaga gaacctgtat tttcagggta gccaccatca tcaccatcac     3360


<210>  275
<211>  1120
<212>  PRT
<213>  Homo Sapien

<400>  275

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Asp Ala 
                245                 250                 255     


His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn 
            260                 265                 270         


Phe Lys Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser 
        275                 280                 285             


Pro Phe Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala 
    290                 295                 300                 


Lys Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu 
305                 310                 315                 320 


His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu 
                325                 330                 335     


Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg 
            340                 345                 350         


Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg 
        355                 360                 365             


Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn 
    370                 375                 380                 


Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His 
385                 390                 395                 400 


Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys 
                405                 410                 415     


Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu 
            420                 425                 430         


Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala 
        435                 440                 445             


Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala 
    450                 455                 460                 


Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala 
465                 470                 475                 480 


Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His 
                485                 490                 495     


Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala 
            500                 505                 510         


Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys 
        515                 520                 525             


Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile 
    530                 535                 540                 


Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala 
545                 550                 555                 560 


Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala 
                565                 570                 575     


Lys Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His 
            580                 585                 590         


Pro Asp Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu 
        595                 600                 605             


Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr 
    610                 615                 620                 


Ala Lys Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn 
625                 630                 635                 640 


Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys 
                645                 650                 655     


Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val 
            660                 665                 670         


Ser Thr Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly 
        675                 680                 685             


Ser Lys Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu 
    690                 695                 700                 


Asp Tyr Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys 
705                 710                 715                 720 


Thr Pro Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val 
                725                 730                 735     


Asn Arg Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val 
            740                 745                 750         


Pro Lys Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys 
        755                 760                 765             


Thr Leu Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val 
    770                 775                 780                 


Glu Leu Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala 
785                 790                 795                 800 


Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp 
                805                 810                 815     


Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala 
            820                 825                 830         


Ser Gln Ala Ala Leu Gly Leu Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        835                 840                 845             


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
    850                 855                 860                 


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
865                 870                 875                 880 


Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln Ala Pro Gly 
                885                 890                 895     


Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly Val Asn Thr 
            900                 905                 910         


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
        915                 920                 925             


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    930                 935                 940                 


Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile 
945                 950                 955                 960 


Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
                965                 970                 975     


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
            980                 985                 990         


Ser Gly Gly Gly Gly Ser Asp Ile  Glu Leu Thr Gln Pro  Pro Ser Val 
        995                 1000                 1005             


Ser Val  Ala Pro Gly Gln Thr  Ala Arg Ile Ser Cys  Ser Gly Asp 
    1010                 1015                 1020             


Ser Leu  Arg Asn Lys Val Tyr  Trp Tyr Gln Gln Lys  Pro Gly Gln 
    1025                 1030                 1035             


Ala Pro  Val Leu Val Ile Tyr  Lys Asn Asn Arg Pro  Ser Gly Ile 
    1040                 1045                 1050             


Pro Glu  Arg Phe Ser Gly Ser  Asn Ser Gly Asn Thr  Ala Thr Leu 
    1055                 1060                 1065             


Thr Ile  Ser Gly Thr Gln Ala  Glu Asp Glu Ala Asp  Tyr Tyr Cys 
    1070                 1075                 1080             


Gln Ser  Tyr Asp Gly Gln Lys  Ser Leu Val Phe Gly  Gly Gly Thr 
    1085                 1090                 1095             


Lys Leu  Thr Val Leu Ala Ala  Ala Glu Asn Leu Tyr  Phe Gln Gly 
    1100                 1105                 1110             


Ser His  His His His His His  
    1115                 1120 


<210>  276
<211>  3360
<212>  DNA
<213>  Homo Sapien

<400>  276
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgggggtggc ggaagtgggg gtgacgctca caagagcgaa      780

gtggcacata ggttcaaaga tctgggcgaa gagaacttta aggccctcgt cctgatcgct      840

ttcgcacagt acctccagca gtctcccttt gaagatcacg tgaaactggt caatgaggtg      900

accgaatttg ccaagacatg cgtggctgat gagagtgcag aaaactgtga caaatcactg      960

catactctct ttggagataa gctgtgcacc gtcgccacac tcagagagac ttatggggaa     1020

atggctgact gttgcgcaaa acaggagcct gaacggaatg agtgtttcct ccagcacaag     1080

gatgacaacc caaatctgcc ccgcctcgtg cgacctgagg tcgatgtgat gtgcaccgcc     1140

tttcatgaca acgaagagac attcctgaag aaatacctgt atgaaattgc tcgtaggcac     1200

ccatactttt atgcccccga gctcctgttc tttgcaaaga gatacaaagc tgccttcact     1260

gaatgttgcc aggcagctga taaggccgca tgtctcctgc ctaaactgga cgagctccgg     1320

gatgaaggta aggcttccag cgccaaacag cgcctgaagt gcgcttctct ccagaagttt     1380

ggcgagcgag cattcaaagc ctgggctgtg gcccgtctca gtcagaggtt tccaaaggca     1440

gaatttgctg aggtctcaaa actggtgacc gacctcacaa aggtccatac tgagtgttgc     1500

cacggagatc tgctggaatg tgccgacgat agagcagacc tcgctaaata tatctgcgag     1560

aatcaggatt ccattagctc taagctgaaa gaatgttgcg agaagcccct cctggaaaag     1620

agtcattgta tcgccgaggt ggaaaacgac gagatgccag cagatctgcc atcactcgct     1680

gccgactttg tggaatccaa agatgtctgc aagaattacg cagaggctaa agacgtgttc     1740

ctggggatgt ttctgtatga gtacgcccgg cgtcaccccg attatagcgt cgtgctcctg     1800

ctccgactgg caaagaccta cgaaacaact ctggagaaat gttgcgctgc cgcagaccct     1860

catgaatgtt atgctaaggt gttcgatgag tttaagccac tcgtcgaaga gccccagaac     1920

ctgattaaac agaattgcga actgttcgag cagctcggtg aatacaagtt tcagaacgcc     1980

ctgctcgtgc gttataccaa aaaggtccct caggtgtcta caccaactct ggtggaggtc     2040

agtaggaatc tgggcaaagt gggatcaaag tgttgcaaac accccgaggc aaagagaatg     2100

ccttgtgctg aagattacct ctccgtcgtg ctgaaccagc tctgcgtgct gcatgaaaag     2160

accccagtca gcgatcgggt gacaaaatgt tgcaccgaat ctctggtcaa tcgccgaccc     2220

tgtttcagtg ccctcgaagt ggacgaaact tatgtgccta aggagtttca ggctgaaaca     2280

ttcacctttc acgccgatat ctgcactctg tccgagaaag aaaggcagat taagaaacag     2340

acagcactgg tcgagctcgt gaagcataaa ccaaaggcta ccaaggagca gctgaaagcc     2400

gtcatggacg atttcgcagc ttttgtggaa aagtgttgca aagccgacga taaggagact     2460

tgtttcgcag aagaggggaa aaagctcgtg gctgccagcc aggcagctct gggtctgggg     2520

ggtggcggaa gtgggggtgg cggaagtggg ggtggcggaa gtcaggttca attggttgaa     2580

agcggtggtg gtctggttca gcctggtggt agcctgcgtc tgagctgtgc agcaagcggt     2640

tttaccttta gcgattatgt gatgaattgg gttcgtcagg caccgggtaa aggtctggaa     2700

tgggttgccg gtattagctg gtcaggtgtt aatacccatt atgcagatag cgtgaaaggt     2760

cgttttacca ttagccgtga taatagcaaa aataccctgt atctgcagat gaatagcctg     2820

cgtgcagaag ataccgcagt ttattattgt gcacgtctgg gtgcaaccgc aaataatatt     2880

cgctataaat ttatggatgt gtggggtcag ggtacactag ttaccgttag cagtggtggt     2940

ggcggcagcg gcggtggcgg ttccggcggt ggtggcagcg gtggtggtgg tagcgatatc     3000

gaactgaccc agcctccgag cgttagcgtt gcaccgggtc agaccgcacg tattagctgt     3060

agcggtgata gtctgcgtaa taaagtttat tggtatcagc agaaaccggg tcaggctccg     3120

gttctggtta tttataaaaa taatcgtccg agcggtattc cggaacgttt tagcggtagc     3180

aatagcggta ataccgcaac cctgaccatt agcggcaccc aggcagaaga tgaagccgat     3240

tattattgtc agagctatga tggtcagaaa agcctggttt ttggtggtgg caccaagctt     3300

accgttctgg cggccgcaga gaacctgtat tttcagggta gccaccatca tcaccatcac     3360


<210>  277
<211>  1091
<212>  PRT
<213>  Homo Sapien

<400>  277

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ser Asp Ala His Lys 
                245                 250                 255     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            260                 265                 270         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe 
        275                 280                 285             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    290                 295                 300                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
305                 310                 315                 320 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                325                 330                 335     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            340                 345                 350         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        355                 360                 365             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    370                 375                 380                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
385                 390                 395                 400 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                405                 410                 415     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            420                 425                 430         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        435                 440                 445             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    450                 455                 460                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
465                 470                 475                 480 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                485                 490                 495     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            500                 505                 510         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        515                 520                 525             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    530                 535                 540                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
545                 550                 555                 560 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                565                 570                 575     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            580                 585                 590         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        595                 600                 605             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    610                 615                 620                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
625                 630                 635                 640 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                645                 650                 655     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            660                 665                 670         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        675                 680                 685             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    690                 695                 700                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
705                 710                 715                 720 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                725                 730                 735     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            740                 745                 750         


Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        755                 760                 765             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    770                 775                 780                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
785                 790                 795                 800 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                805                 810                 815     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            820                 825                 830         


Ala Ala Leu Gly Leu Ala Ala Ala Leu Asp Ile Val Leu Thr Gln Ser 
        835                 840                 845             


Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys 
    850                 855                 860                 


Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr Gln Gln 
865                 870                 875                 880 


Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Asn Arg 
                885                 890                 895     


Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
            900                 905                 910         


Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala Thr Tyr 
        915                 920                 925             


Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln Gly Thr 
    930                 935                 940                 


Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
945                 950                 955                 960 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys Glu Ser 
                965                 970                 975     


Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr Cys Thr 
            980                 985                 990         


Phe Ser Gly Phe Ser Leu Ser Asn  Arg Gly Gly Gly Val  Gly Trp Ile 
        995                 1000                 1005             


Arg Gln  Pro Pro Gly Lys Ala  Leu Glu Trp Leu Ala  Trp Ile Asp 
    1010                 1015                 1020             


Trp Asp  Asp Asp Lys Ser Tyr  Ser Thr Ser Leu Lys  Thr Arg Leu 
    1025                 1030                 1035             


Thr Ile  Ser Lys Asp Thr Ser  Lys Asn Gln Val Val  Leu Thr Met 
    1040                 1045                 1050             


Thr Asn  Met Asp Pro Val Asp  Thr Ala Thr Tyr Tyr  Cys Ala Arg 
    1055                 1060                 1065             


Phe His  Leu Pro Leu Val Phe  Asp Ser Trp Gly Gln  Gly Thr Leu 
    1070                 1075                 1080             


Val Thr  Val Ser Ser Ala Ala  Ala 
    1085                 1090     


<210>  278
<211>  3273
<212>  DNA
<213>  Homo Sapien

<400>  278
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctggcg gcgagcgacg ctcacaagag cgaagtggca      780

cataggttca aagatctggg cgaagagaac tttaaggccc tcgtcctgat cgctttcgca      840

cagtacctcc agcagtctcc ctttgaagat cacgtgaaac tggtcaatga ggtgaccgaa      900

tttgccaaga catgcgtggc tgatgagagt gcagaaaact gtgacaaatc actgcatact      960

ctctttggag ataagctgtg caccgtcgcc acactcagag agacttatgg ggaaatggct     1020

gactgttgcg caaaacagga gcctgaacgg aatgagtgtt tcctccagca caaggatgac     1080

aacccaaatc tgccccgcct cgtgcgacct gaggtcgatg tgatgtgcac cgcctttcat     1140

gacaacgaag agacattcct gaagaaatac ctgtatgaaa ttgctcgtag gcacccatac     1200

ttttatgccc ccgagctcct gttctttgca aagagataca aagctgcctt cactgaatgt     1260

tgccaggcag ctgataaggc cgcatgtctc ctgcctaaac tggacgagct ccgggatgaa     1320

ggtaaggctt ccagcgccaa acagcgcctg aagtgcgctt ctctccagaa gtttggcgag     1380

cgagcattca aagcctgggc tgtggcccgt ctcagtcaga ggtttccaaa ggcagaattt     1440

gctgaggtct caaaactggt gaccgacctc acaaaggtcc atactgagtg ttgccacgga     1500

gatctgctgg aatgtgccga cgatagagca gacctcgcta aatatatctg cgagaatcag     1560

gattccatta gctctaagct gaaagaatgt tgcgagaagc ccctcctgga aaagagtcat     1620

tgtatcgccg aggtggaaaa cgacgagatg ccagcagatc tgccatcact cgctgccgac     1680

tttgtggaat ccaaagatgt ctgcaagaat tacgcagagg ctaaagacgt gttcctgggg     1740

atgtttctgt atgagtacgc ccggcgtcac cccgattata gcgtcgtgct cctgctccga     1800

ctggcaaaga cctacgaaac aactctggag aaatgttgcg ctgccgcaga ccctcatgaa     1860

tgttatgcta aggtgttcga tgagtttaag ccactcgtcg aagagcccca gaacctgatt     1920

aaacagaatt gcgaactgtt cgagcagctc ggtgaataca agtttcagaa cgccctgctc     1980

gtgcgttata ccaaaaaggt ccctcaggtg tctacaccaa ctctggtgga ggtcagtagg     2040

aatctgggca aagtgggatc aaagtgttgc aaacaccccg aggcaaagag aatgccttgt     2100

gctgaagatt acctctccgt cgtgctgaac cagctctgcg tgctgcatga aaagacccca     2160

gtcagcgatc gggtgacaaa atgttgcacc gaatctctgg tcaatcgccg accctgtttc     2220

agtgccctcg aagtggacga aacttatgtg cctaaggagt ttcaggctga aacattcacc     2280

tttcacgccg atatctgcac tctgtccgag aaagaaaggc agattaagaa acagacagca     2340

ctggtcgagc tcgtgaagca taaaccaaag gctaccaagg agcagctgaa agccgtcatg     2400

gacgatttcg cagcttttgt ggaaaagtgt tgcaaagccg acgataagga gacttgtttc     2460

gcagaagagg ggaaaaagct cgtggctgcc agccaggcag ctctgggtct ggcggcggcg     2520

ctggatatcg tgctgacaca gagccctgcc accctgtctc tgagccctgg cgagagagcc     2580

accctgagct gccgggccag ccagttcatc ggctcccgct acctggcctg gtatcagcag     2640

aagcccggac aggctcccag actgctgatc tacggcgcca gcaacagagc taccggcgtg     2700

cccgccagat tttctggcag cggcagcggc accgacttca ccctgaccat cagcagcctg     2760

gaacccgagg acttcgccac ctactactgc cagcagtact acgactaccc ccagaccttc     2820

ggccagggca ccaaggtgga gatcaagggc ggaggcggaa gcgggggtgg cggaagtgga     2880

ggcggaggaa gcggaggggg cggaagccag gtgcaattga aagagtccgg ccctgccctg     2940

gtgaagccta cccagaccct gaccctgaca tgcaccttca gcggcttcag cctgagcaac     3000

agaggcggcg gagtgggctg gatcagacag cctcccggca aggccctgga atggctggcc     3060

tggatcgact gggacgacga caagagctac agcaccagcc tgaaaacccg gctgaccatc     3120

tccaaggaca ccagcaagaa ccaggtggtg ctcaccatga ccaacatgga ccccgtggac     3180

accgccacct attattgcgc ccggtttcat ctgcccctgg tgttcgatag ctggggccag     3240

ggaaccctgg tgacagtgtc cagcgcggcc gca                                  3273


<210>  279
<211>  1091
<212>  PRT
<213>  Homo Sapien

<400>  279

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Ser Asp Ala His Lys Ser Glu 
                245                 250                 255     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            260                 265                 270         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp 
        275                 280                 285             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    290                 295                 300                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
305                 310                 315                 320 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                325                 330                 335     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            340                 345                 350         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        355                 360                 365             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    370                 375                 380                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                405                 410                 415     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            420                 425                 430         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        435                 440                 445             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    450                 455                 460                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
465                 470                 475                 480 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                485                 490                 495     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            500                 505                 510         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        515                 520                 525             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    530                 535                 540                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
545                 550                 555                 560 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                565                 570                 575     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            580                 585                 590         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        595                 600                 605             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    610                 615                 620                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
625                 630                 635                 640 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                645                 650                 655     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            660                 665                 670         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        675                 680                 685             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    690                 695                 700                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
705                 710                 715                 720 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                725                 730                 735     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            740                 745                 750         


Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        755                 760                 765             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    770                 775                 780                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
785                 790                 795                 800 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                805                 810                 815     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            820                 825                 830         


Leu Gly Leu Ala Ala Ala Leu Gln Val Gln Leu Val Glu Ser Gly Gly 
        835                 840                 845             


Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser 
    850                 855                 860                 


Gly Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln Ala Pro 
865                 870                 875                 880 


Gly Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly Val Asn 
                885                 890                 895     


Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
            900                 905                 910         


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
        915                 920                 925             


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn 
    930                 935                 940                 


Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr 
945                 950                 955                 960 


Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
                965                 970                 975     


Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser 
            980                 985                 990         


Val Ser Val Ala Pro Gly Gln Thr  Ala Arg Ile Ser Cys  Ser Gly Asp 
        995                 1000                 1005             


Ser Leu  Arg Asn Lys Val Tyr  Trp Tyr Gln Gln Lys  Pro Gly Gln 
    1010                 1015                 1020             


Ala Pro  Val Leu Val Ile Tyr  Lys Asn Asn Arg Pro  Ser Gly Ile 
    1025                 1030                 1035             


Pro Glu  Arg Phe Ser Gly Ser  Asn Ser Gly Asn Thr  Ala Thr Leu 
    1040                 1045                 1050             


Thr Ile  Ser Gly Thr Gln Ala  Glu Asp Glu Ala Asp  Tyr Tyr Cys 
    1055                 1060                 1065             


Gln Ser  Tyr Asp Gly Gln Lys  Ser Leu Val Phe Gly  Gly Gly Thr 
    1070                 1075                 1080             


Lys Leu  Thr Val Leu Ala Ala  Ala 
    1085                 1090     


<210>  280
<211>  3273
<212>  DNA
<213>  Homo Sapien

<400>  280
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgcggcgagc gacgctcaca agagcgaagt ggcacatagg      780

ttcaaagatc tgggcgaaga gaactttaag gccctcgtcc tgatcgcttt cgcacagtac      840

ctccagcagt ctccctttga agatcacgtg aaactggtca atgaggtgac cgaatttgcc      900

aagacatgcg tggctgatga gagtgcagaa aactgtgaca aatcactgca tactctcttt      960

ggagataagc tgtgcaccgt cgccacactc agagagactt atggggaaat ggctgactgt     1020

tgcgcaaaac aggagcctga acggaatgag tgtttcctcc agcacaagga tgacaaccca     1080

aatctgcccc gcctcgtgcg acctgaggtc gatgtgatgt gcaccgcctt tcatgacaac     1140

gaagagacat tcctgaagaa atacctgtat gaaattgctc gtaggcaccc atacttttat     1200

gcccccgagc tcctgttctt tgcaaagaga tacaaagctg ccttcactga atgttgccag     1260

gcagctgata aggccgcatg tctcctgcct aaactggacg agctccggga tgaaggtaag     1320

gcttccagcg ccaaacagcg cctgaagtgc gcttctctcc agaagtttgg cgagcgagca     1380

ttcaaagcct gggctgtggc ccgtctcagt cagaggtttc caaaggcaga atttgctgag     1440

gtctcaaaac tggtgaccga cctcacaaag gtccatactg agtgttgcca cggagatctg     1500

ctggaatgtg ccgacgatag agcagacctc gctaaatata tctgcgagaa tcaggattcc     1560

attagctcta agctgaaaga atgttgcgag aagcccctcc tggaaaagag tcattgtatc     1620

gccgaggtgg aaaacgacga gatgccagca gatctgccat cactcgctgc cgactttgtg     1680

gaatccaaag atgtctgcaa gaattacgca gaggctaaag acgtgttcct ggggatgttt     1740

ctgtatgagt acgcccggcg tcaccccgat tatagcgtcg tgctcctgct ccgactggca     1800

aagacctacg aaacaactct ggagaaatgt tgcgctgccg cagaccctca tgaatgttat     1860

gctaaggtgt tcgatgagtt taagccactc gtcgaagagc cccagaacct gattaaacag     1920

aattgcgaac tgttcgagca gctcggtgaa tacaagtttc agaacgccct gctcgtgcgt     1980

tataccaaaa aggtccctca ggtgtctaca ccaactctgg tggaggtcag taggaatctg     2040

ggcaaagtgg gatcaaagtg ttgcaaacac cccgaggcaa agagaatgcc ttgtgctgaa     2100

gattacctct ccgtcgtgct gaaccagctc tgcgtgctgc atgaaaagac cccagtcagc     2160

gatcgggtga caaaatgttg caccgaatct ctggtcaatc gccgaccctg tttcagtgcc     2220

ctcgaagtgg acgaaactta tgtgcctaag gagtttcagg ctgaaacatt cacctttcac     2280

gccgatatct gcactctgtc cgagaaagaa aggcagatta agaaacagac agcactggtc     2340

gagctcgtga agcataaacc aaaggctacc aaggagcagc tgaaagccgt catggacgat     2400

ttcgcagctt ttgtggaaaa gtgttgcaaa gccgacgata aggagacttg tttcgcagaa     2460

gaggggaaaa agctcgtggc tgccagccag gcagctctgg gtctggcggc ggcgctgcag     2520

gttcaattgg ttgaaagcgg tggtggtctg gttcagcctg gtggtagcct gcgtctgagc     2580

tgtgcagcaa gcggttttac ctttagcgat tatgtgatga attgggttcg tcaggcaccg     2640

ggtaaaggtc tggaatgggt tgccggtatt agctggtcag gtgttaatac ccattatgca     2700

gatagcgtga aaggtcgttt taccattagc cgtgataata gcaaaaatac cctgtatctg     2760

cagatgaata gcctgcgtgc agaagatacc gcagtttatt attgtgcacg tctgggtgca     2820

accgcaaata atattcgcta taaatttatg gatgtgtggg gtcagggtac actagttacc     2880

gttagcagtg gtggtggcgg cagcggcggt ggcggttccg gcggtggtgg cagcggtggt     2940

ggtggtagcg atatcgaact gacccagcct ccgagcgtta gcgttgcacc gggtcagacc     3000

gcacgtatta gctgtagcgg tgatagtctg cgtaataaag tttattggta tcagcagaaa     3060

ccgggtcagg ctccggttct ggttatttat aaaaataatc gtccgagcgg tattccggaa     3120

cgttttagcg gtagcaatag cggtaatacc gcaaccctga ccattagcgg cacccaggca     3180

gaagatgaag ccgattatta ttgtcagagc tatgatggtc agaaaagcct ggtttttggt     3240

ggtggcacca agcttaccgt tctggcggcc gca                                  3273


<210>  281
<211>  1098
<212>  PRT
<213>  Homo Sapien

<400>  281

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp Ala His Lys Ser Glu Val Ala His 
                245                 250                 255     


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
            260                 265                 270         


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
        275                 280                 285             


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
    290                 295                 300                 


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
305                 310                 315                 320 


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
                325                 330                 335     


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
            340                 345                 350         


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
        355                 360                 365             


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
    370                 375                 380                 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
385                 390                 395                 400 


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
                405                 410                 415     


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
            420                 425                 430         


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
        435                 440                 445             


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
    450                 455                 460                 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
465                 470                 475                 480 


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
                485                 490                 495     


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
            500                 505                 510         


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
        515                 520                 525             


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
    530                 535                 540                 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
545                 550                 555                 560 


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
                565                 570                 575     


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
            580                 585                 590         


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
        595                 600                 605             


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
    610                 615                 620                 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
625                 630                 635                 640 


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
                645                 650                 655     


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
            660                 665                 670         


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
        675                 680                 685             


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
    690                 695                 700                 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
705                 710                 715                 720 


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
                725                 730                 735     


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln Ala Glu 
            740                 745                 750         


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
        755                 760                 765             


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
    770                 775                 780                 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
785                 790                 795                 800 


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
                805                 810                 815     


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            820                 825                 830         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        835                 840                 845             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
    850                 855                 860                 


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
865                 870                 875                 880 


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
                885                 890                 895     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            900                 905                 910         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        915                 920                 925             


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
    930                 935                 940                 


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                965                 970                 975     


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
            980                 985                 990         


Thr Ala Arg Ile Ser Cys Ser Gly  Asp Ser Leu Arg Asn  Lys Val Tyr 
        995                 1000                 1005             


Trp Tyr  Gln Gln Lys Pro Gly  Gln Ala Pro Val Leu  Val Ile Tyr 
    1010                 1015                 1020             


Lys Asn  Asn Arg Pro Ser Gly  Ile Pro Glu Arg Phe  Ser Gly Ser 
    1025                 1030                 1035             


Asn Ser  Gly Asn Thr Ala Thr  Leu Thr Ile Ser Gly  Thr Gln Ala 
    1040                 1045                 1050             


Glu Asp  Glu Ala Asp Tyr Tyr  Cys Gln Ser Tyr Asp  Gly Gln Lys 
    1055                 1060                 1065             


Ser Leu  Val Phe Gly Gly Gly  Thr Lys Leu Thr Val  Leu Ala Ala 
    1070                 1075                 1080             


Ala Glu  Asn Leu Tyr Phe Gln  Gly Ser His His His  His His His 
    1085                 1090                 1095             


<210>  282
<211>  3294
<212>  DNA
<213>  Homo Sapien

<400>  282
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgacgctcac aagagcgaag tggcacatag gttcaaagat      780

ctgggcgaag agaactttaa ggccctcgtc ctgatcgctt tcgcacagta cctccagcag      840

tctccctttg aagatcacgt gaaactggtc aatgaggtga ccgaatttgc caagacatgc      900

gtggctgatg agagtgcaga aaactgtgac aaatcactgc atactctctt tggagataag      960

ctgtgcaccg tcgccacact cagagagact tatggggaaa tggctgactg ttgcgcaaaa     1020

caggagcctg aacggaatga gtgtttcctc cagcacaagg atgacaaccc aaatctgccc     1080

cgcctcgtgc gacctgaggt cgatgtgatg tgcaccgcct ttcatgacaa cgaagagaca     1140

ttcctgaaga aatacctgta tgaaattgct cgtaggcacc catactttta tgcccccgag     1200

ctcctgttct ttgcaaagag atacaaagct gccttcactg aatgttgcca ggcagctgat     1260

aaggccgcat gtctcctgcc taaactggac gagctccggg atgaaggtaa ggcttccagc     1320

gccaaacagc gcctgaagtg cgcttctctc cagaagtttg gcgagcgagc attcaaagcc     1380

tgggctgtgg cccgtctcag tcagaggttt ccaaaggcag aatttgctga ggtctcaaaa     1440

ctggtgaccg acctcacaaa ggtccatact gagtgttgcc acggagatct gctggaatgt     1500

gccgacgata gagcagacct cgctaaatat atctgcgaga atcaggattc cattagctct     1560

aagctgaaag aatgttgcga gaagcccctc ctggaaaaga gtcattgtat cgccgaggtg     1620

gaaaacgacg agatgccagc agatctgcca tcactcgctg ccgactttgt ggaatccaaa     1680

gatgtctgca agaattacgc agaggctaaa gacgtgttcc tggggatgtt tctgtatgag     1740

tacgcccggc gtcaccccga ttatagcgtc gtgctcctgc tccgactggc aaagacctac     1800

gaaacaactc tggagaaatg ttgcgctgcc gcagaccctc atgaatgtta tgctaaggtg     1860

ttcgatgagt ttaagccact cgtcgaagag ccccagaacc tgattaaaca gaattgcgaa     1920

ctgttcgagc agctcggtga atacaagttt cagaacgccc tgctcgtgcg ttataccaaa     1980

aaggtccctc aggtgtctac accaactctg gtggaggtca gtaggaatct gggcaaagtg     2040

ggatcaaagt gttgcaaaca ccccgaggca aagagaatgc cttgtgctga agattacctc     2100

tccgtcgtgc tgaaccagct ctgcgtgctg catgaaaaga ccccagtcag cgatcgggtg     2160

acaaaatgtt gcaccgaatc tctggtcaat cgccgaccct gtttcagtgc cctcgaagtg     2220

gacgaaactt atgtgcctaa ggagtttcag gctgaaacat tcacctttca cgccgatatc     2280

tgcactctgt ccgagaaaga aaggcagatt aagaaacaga cagcactggt cgagctcgtg     2340

aagcataaac caaaggctac caaggagcag ctgaaagccg tcatggacga tttcgcagct     2400

tttgtggaaa agtgttgcaa agccgacgat aaggagactt gtttcgcaga agaggggaaa     2460

aagctcgtgg ctgccagcca ggcagctctg ggtctgcagg ttcaattggt tgaaagcggt     2520

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggttttacc     2580

tttagcgatt atgtgatgaa ttgggttcgt caggcaccgg gtaaaggtct ggaatgggtt     2640

gccggtatta gctggtcagg tgttaatacc cattatgcag atagcgtgaa aggtcgtttt     2700

accattagcc gtgataatag caaaaatacc ctgtatctgc agatgaatag cctgcgtgca     2760

gaagataccg cagtttatta ttgtgcacgt ctgggtgcaa ccgcaaataa tattcgctat     2820

aaatttatgg atgtgtgggg tcagggtaca ctagttaccg ttagcagtgg tggtggcggc     2880

agcggcggtg gcggttccgg cggtggtggc agcggtggtg gtggtagcga tatcgaactg     2940

acccagcctc cgagcgttag cgttgcaccg ggtcagaccg cacgtattag ctgtagcggt     3000

gatagtctgc gtaataaagt ttattggtat cagcagaaac cgggtcaggc tccggttctg     3060

gttatttata aaaataatcg tccgagcggt attccggaac gttttagcgg tagcaatagc     3120

ggtaataccg caaccctgac cattagcggc acccaggcag aagatgaagc cgattattat     3180

tgtcagagct atgatggtca gaaaagcctg gtttttggtg gtggcaccaa gcttaccgtt     3240

ctggcggccg cagagaacct gtattttcag ggtagccacc atcatcacca tcac           3294


<210>  283
<211>  1106
<212>  PRT
<213>  Homo Sapien

<400>  283

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Lys Thr His Thr Asp Ala His Lys Ser 
                245                 250                 255     


Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala 
            260                 265                 270         


Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu 
        275                 280                 285             


Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys 
    290                 295                 300                 


Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu 
305                 310                 315                 320 


Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly 
                325                 330                 335     


Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys 
            340                 345                 350         


Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg 
        355                 360                 365             


Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr 
    370                 375                 380                 


Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe 
385                 390                 395                 400 


Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe 
                405                 410                 415     


Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys 
            420                 425                 430         


Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg 
        435                 440                 445             


Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala 
    450                 455                 460                 


Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala 
465                 470                 475                 480 


Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys 
                485                 490                 495     


Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala 
            500                 505                 510         


Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu 
        515                 520                 525             


Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val 
    530                 535                 540                 


Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe 
545                 550                 555                 560 


Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val 
                565                 570                 575     


Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr 
            580                 585                 590         


Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu 
        595                 600                 605             


Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val 
    610                 615                 620                 


Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys 
625                 630                 635                 640 


Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn 
                645                 650                 655     


Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro 
            660                 665                 670         


Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys 
        675                 680                 685             


Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu 
    690                 695                 700                 


Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val 
705                 710                 715                 720 


Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg 
                725                 730                 735     


Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu 
            740                 745                 750         


Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser 
        755                 760                 765             


Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val 
    770                 775                 780                 


Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp 
785                 790                 795                 800 


Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu 
                805                 810                 815     


Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala 
            820                 825                 830         


Ala Leu Gly Leu Lys Thr His Thr Gln Val Gln Leu Val Glu Ser Gly 
        835                 840                 845             


Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala 
    850                 855                 860                 


Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln Ala 
865                 870                 875                 880 


Pro Gly Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly Val 
                885                 890                 895     


Asn Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg 
            900                 905                 910         


Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala 
        915                 920                 925             


Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn 
    930                 935                 940                 


Asn Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val 
945                 950                 955                 960 


Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
                965                 970                 975     


Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro 
            980                 985                 990         


Ser Val Ser Val Ala Pro Gly Gln  Thr Ala Arg Ile Ser  Cys Ser Gly 
        995                 1000                 1005             


Asp Ser  Leu Arg Asn Lys Val  Tyr Trp Tyr Gln Gln  Lys Pro Gly 
    1010                 1015                 1020             


Gln Ala  Pro Val Leu Val Ile  Tyr Lys Asn Asn Arg  Pro Ser Gly 
    1025                 1030                 1035             


Ile Pro  Glu Arg Phe Ser Gly  Ser Asn Ser Gly Asn  Thr Ala Thr 
    1040                 1045                 1050             


Leu Thr  Ile Ser Gly Thr Gln  Ala Glu Asp Glu Ala  Asp Tyr Tyr 
    1055                 1060                 1065             


Cys Gln  Ser Tyr Asp Gly Gln  Lys Ser Leu Val Phe  Gly Gly Gly 
    1070                 1075                 1080             


Thr Lys  Leu Thr Val Leu Ala  Ala Ala Glu Asn Leu  Tyr Phe Gln 
    1085                 1090                 1095             


Gly Ser  His His His His His  His 
    1100                 1105     


<210>  284
<211>  3318
<212>  DNA
<213>  Homo Sapien

<400>  284
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag caagacccac accgacgctc acaagagcga agtggcacat      780

aggttcaaag atctgggcga agagaacttt aaggccctcg tcctgatcgc tttcgcacag      840

tacctccagc agtctccctt tgaagatcac gtgaaactgg tcaatgaggt gaccgaattt      900

gccaagacat gcgtggctga tgagagtgca gaaaactgtg acaaatcact gcatactctc      960

tttggagata agctgtgcac cgtcgccaca ctcagagaga cttatgggga aatggctgac     1020

tgttgcgcaa aacaggagcc tgaacggaat gagtgtttcc tccagcacaa ggatgacaac     1080

ccaaatctgc cccgcctcgt gcgacctgag gtcgatgtga tgtgcaccgc ctttcatgac     1140

aacgaagaga cattcctgaa gaaatacctg tatgaaattg ctcgtaggca cccatacttt     1200

tatgcccccg agctcctgtt ctttgcaaag agatacaaag ctgccttcac tgaatgttgc     1260

caggcagctg ataaggccgc atgtctcctg cctaaactgg acgagctccg ggatgaaggt     1320

aaggcttcca gcgccaaaca gcgcctgaag tgcgcttctc tccagaagtt tggcgagcga     1380

gcattcaaag cctgggctgt ggcccgtctc agtcagaggt ttccaaaggc agaatttgct     1440

gaggtctcaa aactggtgac cgacctcaca aaggtccata ctgagtgttg ccacggagat     1500

ctgctggaat gtgccgacga tagagcagac ctcgctaaat atatctgcga gaatcaggat     1560

tccattagct ctaagctgaa agaatgttgc gagaagcccc tcctggaaaa gagtcattgt     1620

atcgccgagg tggaaaacga cgagatgcca gcagatctgc catcactcgc tgccgacttt     1680

gtggaatcca aagatgtctg caagaattac gcagaggcta aagacgtgtt cctggggatg     1740

tttctgtatg agtacgcccg gcgtcacccc gattatagcg tcgtgctcct gctccgactg     1800

gcaaagacct acgaaacaac tctggagaaa tgttgcgctg ccgcagaccc tcatgaatgt     1860

tatgctaagg tgttcgatga gtttaagcca ctcgtcgaag agccccagaa cctgattaaa     1920

cagaattgcg aactgttcga gcagctcggt gaatacaagt ttcagaacgc cctgctcgtg     1980

cgttatacca aaaaggtccc tcaggtgtct acaccaactc tggtggaggt cagtaggaat     2040

ctgggcaaag tgggatcaaa gtgttgcaaa caccccgagg caaagagaat gccttgtgct     2100

gaagattacc tctccgtcgt gctgaaccag ctctgcgtgc tgcatgaaaa gaccccagtc     2160

agcgatcggg tgacaaaatg ttgcaccgaa tctctggtca atcgccgacc ctgtttcagt     2220

gccctcgaag tggacgaaac ttatgtgcct aaggagtttc aggctgaaac attcaccttt     2280

cacgccgata tctgcactct gtccgagaaa gaaaggcaga ttaagaaaca gacagcactg     2340

gtcgagctcg tgaagcataa accaaaggct accaaggagc agctgaaagc cgtcatggac     2400

gatttcgcag cttttgtgga aaagtgttgc aaagccgacg ataaggagac ttgtttcgca     2460

gaagagggga aaaagctcgt ggctgccagc caggcagctc tgggtctgaa gacccacacc     2520

caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg     2580

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca     2640

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat     2700

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat     2760

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt     2820

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt     2880

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt     2940

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag     3000

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag     3060

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg     3120

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag     3180

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt     3240

ggtggtggca ccaagcttac cgttctggcg gccgcagaga acctgtattt tcagggtagc     3300

caccatcatc accatcac                                                   3318


<210>  285
<211>  528
<212>  PRT
<213>  Homo Sapien

<400>  285

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            260                 265                 270         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        275                 280                 285             


Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly Val Asn Thr 
305                 310                 315                 320 


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile 
        355                 360                 365             


Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val 
                405                 410                 415     


Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser 
            420                 425                 430         


Leu Arg Asn Lys Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        435                 440                 445             


Val Leu Val Ile Tyr Lys Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg 
    450                 455                 460                 


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
465                 470                 475                 480 


Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                485                 490                 495     


Gln Lys Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Ala 
            500                 505                 510         


Ala Ala Glu Asn Leu Tyr Phe Gln Gly Ser His His His His His His 
        515                 520                 525             


<210>  286
<211>  1584
<212>  DNA
<213>  Homo Sapien

<400>  286
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cggaggtggc gggagtggtg gagggggctc aggcgggggt      780

ggatctcagg ttcaattggt tgaaagcggt ggtggtctgg ttcagcctgg tggtagcctg      840

cgtctgagct gtgcagcaag cggttttacc tttagcgatt atgtgatgaa ttgggttcgt      900

caggcaccgg gtaaaggtct ggaatgggtt gccggtatta gctggtcagg tgttaatacc      960

cattatgcag atagcgtgaa aggtcgtttt accattagcc gtgataatag caaaaatacc     1020

ctgtatctgc agatgaatag cctgcgtgca gaagataccg cagtttatta ttgtgcacgt     1080

ctgggtgcaa ccgcaaataa tattcgctat aaatttatgg atgtgtgggg tcagggtaca     1140

ctagttaccg ttagcagtgg tggtggcggc agcggcggtg gcggttccgg cggtggtggc     1200

agcggtggtg gtggtagcga tatcgaactg acccagcctc cgagcgttag cgttgcaccg     1260

ggtcagaccg cacgtattag ctgtagcggt gatagtctgc gtaataaagt ttattggtat     1320

cagcagaaac cgggtcaggc tccggttctg gttatttata aaaataatcg tccgagcggt     1380

attccggaac gttttagcgg tagcaatagc ggtaataccg caaccctgac cattagcggc     1440

acccaggcag aagatgaagc cgattattat tgtcagagct atgatggtca gaaaagcctg     1500

gtttttggtg gtggcaccaa gcttaccgtt ctggcggccg cagagaacct gtattttcag     1560

ggtagccacc atcatcacca tcac                                            1584


<210>  287
<211>  1110
<212>  PRT
<213>  Homo Sapien

<400>  287

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser Gly Gly Gly 
            260                 265                 270         


Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly 
        275                 280                 285             


Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln Ala Pro Gly 
    290                 295                 300                 


Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly Val Asn Thr 
305                 310                 315                 320 


His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn 
                325                 330                 335     


Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
            340                 345                 350         


Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile 
        355                 360                 365             


Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu Val Thr Val 
    370                 375                 380                 


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
385                 390                 395                 400 


Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro Pro Ser Val 
                405                 410                 415     


Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser 
            420                 425                 430         


Leu Arg Asn Lys Val Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        435                 440                 445             


Val Leu Val Ile Tyr Lys Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg 
    450                 455                 460                 


Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly 
465                 470                 475                 480 


Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly 
                485                 490                 495     


Gln Lys Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Asp 
            500                 505                 510         


Lys Thr His Thr Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys 
        515                 520                 525             


Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile Ala Phe Ala 
    530                 535                 540                 


Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys Leu Val Asn 
545                 550                 555                 560 


Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu Ser Ala Glu 
                565                 570                 575     


Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr 
            580                 585                 590         


Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala 
        595                 600                 605             


Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp 
    610                 615                 620                 


Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp Val Met Cys 
625                 630                 635                 640 


Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys Tyr Leu Tyr 
                645                 650                 655     


Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe 
            660                 665                 670         


Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala 
        675                 680                 685             


Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu Arg Asp Glu 
    690                 695                 700                 


Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala Ser Leu Gln 
705                 710                 715                 720 


Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser 
                725                 730                 735     


Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr 
            740                 745                 750         


Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu 
        755                 760                 765             


Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln 
    770                 775                 780                 


Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu 
785                 790                 795                 800 


Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala 
                805                 810                 815     


Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys 
            820                 825                 830         


Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met Phe Leu Tyr 
        835                 840                 845             


Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg 
    850                 855                 860                 


Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys Ala Ala Ala 
865                 870                 875                 880 


Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe Lys Pro Leu 
                885                 890                 895     


Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu Leu Phe Glu 
            900                 905                 910         


Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val Arg Tyr Thr 
        915                 920                 925             


Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg 
    930                 935                 940                 


Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro Glu Ala Lys 
945                 950                 955                 960 


Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Asn Gln Leu 
                965                 970                 975     


Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val Thr Lys Cys 
            980                 985                 990         


Cys Thr Glu Ser Leu Val Asn Arg  Arg Pro Cys Phe Ser  Ala Leu Glu 
        995                 1000                 1005             


Val Asp  Glu Thr Tyr Val Pro  Lys Glu Phe Gln Ala  Glu Thr Phe 
    1010                 1015                 1020             


Thr Phe  His Ala Asp Ile Cys  Thr Leu Ser Glu Lys  Glu Arg Gln 
    1025                 1030                 1035             


Ile Lys  Lys Gln Thr Ala Leu  Val Glu Leu Val Lys  His Lys Pro 
    1040                 1045                 1050             


Lys Ala  Thr Lys Glu Gln Leu  Lys Ala Val Met Asp  Asp Phe Ala 
    1055                 1060                 1065             


Ala Phe  Val Glu Lys Cys Cys  Lys Ala Asp Asp Lys  Glu Thr Cys 
    1070                 1075                 1080             


Phe Ala  Glu Glu Gly Lys Lys  Leu Val Ala Ala Ser  Gln Ala Ala 
    1085                 1090                 1095             


Leu Gly  Leu Ala Ala Ala His  His His His His His  
    1100                 1105                 1110 


<210>  288
<211>  3330
<212>  DNA
<213>  Homo Sapien

<400>  288
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cggaggtggc gggagtggtg gagggggctc aggcgggggt      780

ggatctcagg ttcaattggt tgaaagcggt ggtggtctgg ttcagcctgg tggtagcctg      840

cgtctgagct gtgcagcaag cggttttacc tttagcgatt atgtgatgaa ttgggttcgt      900

caggcaccgg gtaaaggtct ggaatgggtt gccggtatta gctggtcagg tgttaatacc      960

cattatgcag atagcgtgaa aggtcgtttt accattagcc gtgataatag caaaaatacc     1020

ctgtatctgc agatgaatag cctgcgtgca gaagataccg cagtttatta ttgtgcacgt     1080

ctgggtgcaa ccgcaaataa tattcgctat aaatttatgg atgtgtgggg tcagggtaca     1140

ctagttaccg ttagcagtgg tggtggcggc agcggcggtg gcggttccgg cggtggtggc     1200

agcggtggtg gtggtagcga tatcgaactg acccagcctc cgagcgttag cgttgcaccg     1260

ggtcagaccg cacgtattag ctgtagcggt gatagtctgc gtaataaagt ttattggtat     1320

cagcagaaac cgggtcaggc tccggttctg gttatttata aaaataatcg tccgagcggt     1380

attccggaac gttttagcgg tagcaatagc ggtaataccg caaccctgac cattagcggc     1440

acccaggcag aagatgaagc cgattattat tgtcagagct atgatggtca gaaaagcctg     1500

gtttttggtg gtggcaccaa gcttaccgtt ctggacaaga cccacaccga cgctcacaag     1560

agcgaagtgg cacataggtt caaagatctg ggcgaagaga actttaaggc cctcgtcctg     1620

atcgctttcg cacagtacct ccagcagtct ccctttgaag atcacgtgaa actggtcaat     1680

gaggtgaccg aatttgccaa gacatgcgtg gctgatgaga gtgcagaaaa ctgtgacaaa     1740

tcactgcata ctctctttgg agataagctg tgcaccgtcg ccacactcag agagacttat     1800

ggggaaatgg ctgactgttg cgcaaaacag gagcctgaac ggaatgagtg tttcctccag     1860

cacaaggatg acaacccaaa tctgccccgc ctcgtgcgac ctgaggtcga tgtgatgtgc     1920

accgcctttc atgacaacga agagacattc ctgaagaaat acctgtatga aattgctcgt     1980

aggcacccat acttttatgc ccccgagctc ctgttctttg caaagagata caaagctgcc     2040

ttcactgaat gttgccaggc agctgataag gccgcatgtc tcctgcctaa actggacgag     2100

ctccgggatg aaggtaaggc ttccagcgcc aaacagcgcc tgaagtgcgc ttctctccag     2160

aagtttggcg agcgagcatt caaagcctgg gctgtggccc gtctcagtca gaggtttcca     2220

aaggcagaat ttgctgaggt ctcaaaactg gtgaccgacc tcacaaaggt ccatactgag     2280

tgttgccacg gagatctgct ggaatgtgcc gacgatagag cagacctcgc taaatatatc     2340

tgcgagaatc aggattccat tagctctaag ctgaaagaat gttgcgagaa gcccctcctg     2400

gaaaagagtc attgtatcgc cgaggtggaa aacgacgaga tgccagcaga tctgccatca     2460

ctcgctgccg actttgtgga atccaaagat gtctgcaaga attacgcaga ggctaaagac     2520

gtgttcctgg ggatgtttct gtatgagtac gcccggcgtc accccgatta tagcgtcgtg     2580

ctcctgctcc gactggcaaa gacctacgaa acaactctgg agaaatgttg cgctgccgca     2640

gaccctcatg aatgttatgc taaggtgttc gatgagttta agccactcgt cgaagagccc     2700

cagaacctga ttaaacagaa ttgcgaactg ttcgagcagc tcggtgaata caagtttcag     2760

aacgccctgc tcgtgcgtta taccaaaaag gtccctcagg tgtctacacc aactctggtg     2820

gaggtcagta ggaatctggg caaagtggga tcaaagtgtt gcaaacaccc cgaggcaaag     2880

agaatgcctt gtgctgaaga ttacctctcc gtcgtgctga accagctctg cgtgctgcat     2940

gaaaagaccc cagtcagcga tcgggtgaca aaatgttgca ccgaatctct ggtcaatcgc     3000

cgaccctgtt tcagtgccct cgaagtggac gaaacttatg tgcctaagga gtttcaggct     3060

gaaacattca cctttcacgc cgatatctgc actctgtccg agaaagaaag gcagattaag     3120

aaacagacag cactggtcga gctcgtgaag cataaaccaa aggctaccaa ggagcagctg     3180

aaagccgtca tggacgattt cgcagctttt gtggaaaagt gttgcaaagc cgacgataag     3240

gagacttgtt tcgcagaaga ggggaaaaag ctcgtggctg ccagccaggc agctctgggt     3300

ctggcagctg cccatcacca ccatcatcat                                      3330


<210>  289
<211>  854
<212>  PRT
<213>  Homo Sapien

<400>  289

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Ala Ala Ser Asp Ala His Lys 
                245                 250                 255     


Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys 
            260                 265                 270         


Ala Leu Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe 
        275                 280                 285             


Glu Asp His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr 
    290                 295                 300                 


Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr 
305                 310                 315                 320 


Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr 
                325                 330                 335     


Gly Glu Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu 
            340                 345                 350         


Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val 
        355                 360                 365             


Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu 
    370                 375                 380                 


Thr Phe Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr 
385                 390                 395                 400 


Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala 
                405                 410                 415     


Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro 
            420                 425                 430         


Lys Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln 
        435                 440                 445             


Arg Leu Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys 
    450                 455                 460                 


Ala Trp Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe 
465                 470                 475                 480 


Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu 
                485                 490                 495     


Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu 
            500                 505                 510         


Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys 
        515                 520                 525             


Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu 
    530                 535                 540                 


Val Glu Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp 
545                 550                 555                 560 


Phe Val Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp 
                565                 570                 575     


Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp 
            580                 585                 590         


Tyr Ser Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr 
        595                 600                 605             


Leu Glu Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys 
    610                 615                 620                 


Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile 
625                 630                 635                 640 


Lys Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln 
                645                 650                 655     


Asn Ala Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr 
            660                 665                 670         


Pro Thr Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys 
        675                 680                 685             


Cys Cys Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr 
    690                 695                 700                 


Leu Ser Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro 
705                 710                 715                 720 


Val Ser Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg 
                725                 730                 735     


Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys 
            740                 745                 750         


Glu Phe Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu 
        755                 760                 765             


Ser Glu Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu 
    770                 775                 780                 


Val Lys His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met 
785                 790                 795                 800 


Asp Asp Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys 
                805                 810                 815     


Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln 
            820                 825                 830         


Ala Ala Leu Gly Leu Ala Ala Ala Glu Asn Leu Tyr Phe Gln Gly Ser 
        835                 840                 845             


His His His His His His 
    850                 


<210>  290
<211>  2562
<212>  DNA
<213>  Homo Sapien

<400>  290
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctggcg gcgagcgacg ctcacaagag cgaagtggca      780

cataggttca aagatctggg cgaagagaac tttaaggccc tcgtcctgat cgctttcgca      840

cagtacctcc agcagtctcc ctttgaagat cacgtgaaac tggtcaatga ggtgaccgaa      900

tttgccaaga catgcgtggc tgatgagagt gcagaaaact gtgacaaatc actgcatact      960

ctctttggag ataagctgtg caccgtcgcc acactcagag agacttatgg ggaaatggct     1020

gactgttgcg caaaacagga gcctgaacgg aatgagtgtt tcctccagca caaggatgac     1080

aacccaaatc tgccccgcct cgtgcgacct gaggtcgatg tgatgtgcac cgcctttcat     1140

gacaacgaag agacattcct gaagaaatac ctgtatgaaa ttgctcgtag gcacccatac     1200

ttttatgccc ccgagctcct gttctttgca aagagataca aagctgcctt cactgaatgt     1260

tgccaggcag ctgataaggc cgcatgtctc ctgcctaaac tggacgagct ccgggatgaa     1320

ggtaaggctt ccagcgccaa acagcgcctg aagtgcgctt ctctccagaa gtttggcgag     1380

cgagcattca aagcctgggc tgtggcccgt ctcagtcaga ggtttccaaa ggcagaattt     1440

gctgaggtct caaaactggt gaccgacctc acaaaggtcc atactgagtg ttgccacgga     1500

gatctgctgg aatgtgccga cgatagagca gacctcgcta aatatatctg cgagaatcag     1560

gattccatta gctctaagct gaaagaatgt tgcgagaagc ccctcctgga aaagagtcat     1620

tgtatcgccg aggtggaaaa cgacgagatg ccagcagatc tgccatcact cgctgccgac     1680

tttgtggaat ccaaagatgt ctgcaagaat tacgcagagg ctaaagacgt gttcctgggg     1740

atgtttctgt atgagtacgc ccggcgtcac cccgattata gcgtcgtgct cctgctccga     1800

ctggcaaaga cctacgaaac aactctggag aaatgttgcg ctgccgcaga ccctcatgaa     1860

tgttatgcta aggtgttcga tgagtttaag ccactcgtcg aagagcccca gaacctgatt     1920

aaacagaatt gcgaactgtt cgagcagctc ggtgaataca agtttcagaa cgccctgctc     1980

gtgcgttata ccaaaaaggt ccctcaggtg tctacaccaa ctctggtgga ggtcagtagg     2040

aatctgggca aagtgggatc aaagtgttgc aaacaccccg aggcaaagag aatgccttgt     2100

gctgaagatt acctctccgt cgtgctgaac cagctctgcg tgctgcatga aaagacccca     2160

gtcagcgatc gggtgacaaa atgttgcacc gaatctctgg tcaatcgccg accctgtttc     2220

agtgccctcg aagtggacga aacttatgtg cctaaggagt ttcaggctga aacattcacc     2280

tttcacgccg atatctgcac tctgtccgag aaagaaaggc agattaagaa acagacagca     2340

ctggtcgagc tcgtgaagca taaaccaaag gctaccaagg agcagctgaa agccgtcatg     2400

gacgatttcg cagcttttgt ggaaaagtgt tgcaaagccg acgataagga gacttgtttc     2460

gcagaagagg ggaaaaagct cgtggctgcc agccaggcag ctctgggtct ggcggccgca     2520

gagaacctgt attttcaggg tagccaccat catcaccatc ac                        2562


<210>  291
<211>  852
<212>  PRT
<213>  Homo Sapien

<400>  291

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Ala Ala Ser Asp Ala His Lys Ser Glu 
                245                 250                 255     


Val Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu 
            260                 265                 270         


Val Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp 
        275                 280                 285             


His Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val 
    290                 295                 300                 


Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe 
305                 310                 315                 320 


Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu 
                325                 330                 335     


Met Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe 
            340                 345                 350         


Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro 
        355                 360                 365             


Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe 
    370                 375                 380                 


Leu Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr 
385                 390                 395                 400 


Ala Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr 
                405                 410                 415     


Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu 
            420                 425                 430         


Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu 
        435                 440                 445             


Lys Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp 
    450                 455                 460                 


Ala Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu 
465                 470                 475                 480 


Val Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys 
                485                 490                 495     


His Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys 
            500                 505                 510         


Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys 
        515                 520                 525             


Cys Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu 
    530                 535                 540                 


Asn Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val 
545                 550                 555                 560 


Glu Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe 
                565                 570                 575     


Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser 
            580                 585                 590         


Val Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu 
        595                 600                 605             


Lys Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe 
    610                 615                 620                 


Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln 
625                 630                 635                 640 


Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala 
                645                 650                 655     


Leu Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr 
            660                 665                 670         


Leu Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys 
        675                 680                 685             


Lys His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser 
    690                 695                 700                 


Val Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser 
705                 710                 715                 720 


Asp Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro 
                725                 730                 735     


Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe 
            740                 745                 750         


Gln Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu 
        755                 760                 765             


Lys Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys 
    770                 775                 780                 


His Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp 
785                 790                 795                 800 


Phe Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr 
                805                 810                 815     


Cys Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala 
            820                 825                 830         


Leu Gly Leu Ala Ala Ala Glu Asn Leu Tyr Phe Gln Gly Ser His His 
        835                 840                 845             


His His His His 
    850         


<210>  292
<211>  2556
<212>  DNA
<213>  Homo Sapien

<400>  292
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgcggcgagc gacgctcaca agagcgaagt ggcacatagg      780

ttcaaagatc tgggcgaaga gaactttaag gccctcgtcc tgatcgcttt cgcacagtac      840

ctccagcagt ctccctttga agatcacgtg aaactggtca atgaggtgac cgaatttgcc      900

aagacatgcg tggctgatga gagtgcagaa aactgtgaca aatcactgca tactctcttt      960

ggagataagc tgtgcaccgt cgccacactc agagagactt atggggaaat ggctgactgt     1020

tgcgcaaaac aggagcctga acggaatgag tgtttcctcc agcacaagga tgacaaccca     1080

aatctgcccc gcctcgtgcg acctgaggtc gatgtgatgt gcaccgcctt tcatgacaac     1140

gaagagacat tcctgaagaa atacctgtat gaaattgctc gtaggcaccc atacttttat     1200

gcccccgagc tcctgttctt tgcaaagaga tacaaagctg ccttcactga atgttgccag     1260

gcagctgata aggccgcatg tctcctgcct aaactggacg agctccggga tgaaggtaag     1320

gcttccagcg ccaaacagcg cctgaagtgc gcttctctcc agaagtttgg cgagcgagca     1380

ttcaaagcct gggctgtggc ccgtctcagt cagaggtttc caaaggcaga atttgctgag     1440

gtctcaaaac tggtgaccga cctcacaaag gtccatactg agtgttgcca cggagatctg     1500

ctggaatgtg ccgacgatag agcagacctc gctaaatata tctgcgagaa tcaggattcc     1560

attagctcta agctgaaaga atgttgcgag aagcccctcc tggaaaagag tcattgtatc     1620

gccgaggtgg aaaacgacga gatgccagca gatctgccat cactcgctgc cgactttgtg     1680

gaatccaaag atgtctgcaa gaattacgca gaggctaaag acgtgttcct ggggatgttt     1740

ctgtatgagt acgcccggcg tcaccccgat tatagcgtcg tgctcctgct ccgactggca     1800

aagacctacg aaacaactct ggagaaatgt tgcgctgccg cagaccctca tgaatgttat     1860

gctaaggtgt tcgatgagtt taagccactc gtcgaagagc cccagaacct gattaaacag     1920

aattgcgaac tgttcgagca gctcggtgaa tacaagtttc agaacgccct gctcgtgcgt     1980

tataccaaaa aggtccctca ggtgtctaca ccaactctgg tggaggtcag taggaatctg     2040

ggcaaagtgg gatcaaagtg ttgcaaacac cccgaggcaa agagaatgcc ttgtgctgaa     2100

gattacctct ccgtcgtgct gaaccagctc tgcgtgctgc atgaaaagac cccagtcagc     2160

gatcgggtga caaaatgttg caccgaatct ctggtcaatc gccgaccctg tttcagtgcc     2220

ctcgaagtgg acgaaactta tgtgcctaag gagtttcagg ctgaaacatt cacctttcac     2280

gccgatatct gcactctgtc cgagaaagaa aggcagatta agaaacagac agcactggtc     2340

gagctcgtga agcataaacc aaaggctacc aaggagcagc tgaaagccgt catggacgat     2400

ttcgcagctt ttgtggaaaa gtgttgcaaa gccgacgata aggagacttg tttcgcagaa     2460

gaggggaaaa agctcgtggc tgccagccag gcagctctgg gtctggcggc cgcagagaac     2520

ctgtattttc agggtagcca ccatcatcac catcac                               2556


<210>  293
<211>  1084
<212>  PRT
<213>  Homo Sapien

<400>  293

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Asp Ala His Lys Ser Glu Val 
                245                 250                 255     


Ala His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val 
            260                 265                 270         


Leu Ile Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His 
        275                 280                 285             


Val Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala 
    290                 295                 300                 


Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly 
305                 310                 315                 320 


Asp Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met 
                325                 330                 335     


Ala Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu 
            340                 345                 350         


Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu 
        355                 360                 365             


Val Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu 
    370                 375                 380                 


Lys Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala 
385                 390                 395                 400 


Pro Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu 
                405                 410                 415     


Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp 
            420                 425                 430         


Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys 
        435                 440                 445             


Cys Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala 
    450                 455                 460                 


Val Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val 
465                 470                 475                 480 


Ser Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His 
                485                 490                 495     


Gly Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr 
            500                 505                 510         


Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys 
        515                 520                 525             


Glu Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn 
    530                 535                 540                 


Asp Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu 
545                 550                 555                 560 


Ser Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu 
                565                 570                 575     


Gly Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val 
            580                 585                 590         


Val Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys 
        595                 600                 605             


Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp 
    610                 615                 620                 


Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn 
625                 630                 635                 640 


Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu 
                645                 650                 655     


Leu Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu 
            660                 665                 670         


Val Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys 
        675                 680                 685             


His Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val 
    690                 695                 700                 


Val Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp 
705                 710                 715                 720 


Arg Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys 
                725                 730                 735     


Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln 
            740                 745                 750         


Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys 
        755                 760                 765             


Glu Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His 
    770                 775                 780                 


Lys Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe 
785                 790                 795                 800 


Ala Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys 
                805                 810                 815     


Phe Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu 
            820                 825                 830         


Gly Leu Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser 
        835                 840                 845             


Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly 
    850                 855                 860                 


Ser Arg Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg 
865                 870                 875                 880 


Leu Leu Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg 
                885                 890                 895     


Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser 
            900                 905                 910         


Leu Glu Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp 
        915                 920                 925             


Tyr Pro Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly 
    930                 935                 940                 


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
945                 950                 955                 960 


Gly Ser Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro 
                965                 970                 975     


Thr Gln Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser 
            980                 985                 990         


Asn Arg Gly Gly Gly Val Gly Trp  Ile Arg Gln Pro Pro  Gly Lys Ala 
        995                 1000                 1005             


Leu Glu  Trp Leu Ala Trp Ile  Asp Trp Asp Asp Asp  Lys Ser Tyr 
    1010                 1015                 1020             


Ser Thr  Ser Leu Lys Thr Arg  Leu Thr Ile Ser Lys  Asp Thr Ser 
    1025                 1030                 1035             


Lys Asn  Gln Val Val Leu Thr  Met Thr Asn Met Asp  Pro Val Asp 
    1040                 1045                 1050             


Thr Ala  Thr Tyr Tyr Cys Ala  Arg Phe His Leu Pro  Leu Val Phe 
    1055                 1060                 1065             


Asp Ser  Trp Gly Gln Gly Thr  Leu Val Thr Val Ser  Ser Ala Ala 
    1070                 1075                 1080             


Ala 
    


<210>  294
<211>  3252
<212>  DNA
<213>  Homo Sapien

<400>  294
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gctcttacga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctggac gctcacaaga gcgaagtggc acataggttc      780

aaagatctgg gcgaagagaa ctttaaggcc ctcgtcctga tcgctttcgc acagtacctc      840

cagcagtctc cctttgaaga tcacgtgaaa ctggtcaatg aggtgaccga atttgccaag      900

acatgcgtgg ctgatgagag tgcagaaaac tgtgacaaat cactgcatac tctctttgga      960

gataagctgt gcaccgtcgc cacactcaga gagacttatg gggaaatggc tgactgttgc     1020

gcaaaacagg agcctgaacg gaatgagtgt ttcctccagc acaaggatga caacccaaat     1080

ctgccccgcc tcgtgcgacc tgaggtcgat gtgatgtgca ccgcctttca tgacaacgaa     1140

gagacattcc tgaagaaata cctgtatgaa attgctcgta ggcacccata cttttatgcc     1200

cccgagctcc tgttctttgc aaagagatac aaagctgcct tcactgaatg ttgccaggca     1260

gctgataagg ccgcatgtct cctgcctaaa ctggacgagc tccgggatga aggtaaggct     1320

tccagcgcca aacagcgcct gaagtgcgct tctctccaga agtttggcga gcgagcattc     1380

aaagcctggg ctgtggcccg tctcagtcag aggtttccaa aggcagaatt tgctgaggtc     1440

tcaaaactgg tgaccgacct cacaaaggtc catactgagt gttgccacgg agatctgctg     1500

gaatgtgccg acgatagagc agacctcgct aaatatatct gcgagaatca ggattccatt     1560

agctctaagc tgaaagaatg ttgcgagaag cccctcctgg aaaagagtca ttgtatcgcc     1620

gaggtggaaa acgacgagat gccagcagat ctgccatcac tcgctgccga ctttgtggaa     1680

tccaaagatg tctgcaagaa ttacgcagag gctaaagacg tgttcctggg gatgtttctg     1740

tatgagtacg cccggcgtca ccccgattat agcgtcgtgc tcctgctccg actggcaaag     1800

acctacgaaa caactctgga gaaatgttgc gctgccgcag accctcatga atgttatgct     1860

aaggtgttcg atgagtttaa gccactcgtc gaagagcccc agaacctgat taaacagaat     1920

tgcgaactgt tcgagcagct cggtgaatac aagtttcaga acgccctgct cgtgcgttat     1980

accaaaaagg tccctcaggt gtctacacca actctggtgg aggtcagtag gaatctgggc     2040

aaagtgggat caaagtgttg caaacacccc gaggcaaaga gaatgccttg tgctgaagat     2100

tacctctccg tcgtgctgaa ccagctctgc gtgctgcatg aaaagacccc agtcagcgat     2160

cgggtgacaa aatgttgcac cgaatctctg gtcaatcgcc gaccctgttt cagtgccctc     2220

gaagtggacg aaacttatgt gcctaaggag tttcaggctg aaacattcac ctttcacgcc     2280

gatatctgca ctctgtccga gaaagaaagg cagattaaga aacagacagc actggtcgag     2340

ctcgtgaagc ataaaccaaa ggctaccaag gagcagctga aagccgtcat ggacgatttc     2400

gcagcttttg tggaaaagtg ttgcaaagcc gacgataagg agacttgttt cgcagaagag     2460

gggaaaaagc tcgtggctgc cagccaggca gctctgggtc tggatatcgt gctgacacag     2520

agccctgcca ccctgtctct gagccctggc gagagagcca ccctgagctg ccgggccagc     2580

cagttcatcg gctcccgcta cctggcctgg tatcagcaga agcccggaca ggctcccaga     2640

ctgctgatct acggcgccag caacagagct accggcgtgc ccgccagatt ttctggcagc     2700

ggcagcggca ccgacttcac cctgaccatc agcagcctgg aacccgagga cttcgccacc     2760

tactactgcc agcagtacta cgactacccc cagaccttcg gccagggcac caaggtggag     2820

atcaagggcg gaggcggaag cgggggtggc ggaagtggag gcggaggaag cggagggggc     2880

ggaagccagg tgcaattgaa agagtccggc cctgccctgg tgaagcctac ccagaccctg     2940

accctgacat gcaccttcag cggcttcagc ctgagcaaca gaggcggcgg agtgggctgg     3000

atcagacagc ctcccggcaa ggccctggaa tggctggcct ggatcgactg ggacgacgac     3060

aagagctaca gcaccagcct gaaaacccgg ctgaccatct ccaaggacac cagcaagaac     3120

caggtggtgc tcaccatgac caacatggac cccgtggaca ccgccaccta ttattgcgcc     3180

cggtttcatc tgcccctggt gttcgatagc tggggccagg gaaccctggt gacagtgtcc     3240

agcgcggccg ca                                                         3252


<210>  295
<211>  1084
<212>  PRT
<213>  Homo Sapien

<400>  295

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp Ala His Lys Ser Glu Val Ala His 
                245                 250                 255     


Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu Ile 
            260                 265                 270         


Ala Phe Ala Gln Tyr Leu Gln Gln Ser Pro Phe Glu Asp His Val Lys 
        275                 280                 285             


Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu 
    290                 295                 300                 


Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp Lys 
305                 310                 315                 320 


Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp 
                325                 330                 335     


Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His 
            340                 345                 350         


Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val Asp 
        355                 360                 365             


Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys Lys 
    370                 375                 380                 


Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro Glu 
385                 390                 395                 400 


Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys Cys 
                405                 410                 415     


Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu Leu 
            420                 425                 430         


Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys Ala 
        435                 440                 445             


Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala 
    450                 455                 460                 


Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys 
465                 470                 475                 480 


Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly Asp 
                485                 490                 495     


Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile Cys 
            500                 505                 510         


Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu Lys 
        515                 520                 525             


Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu 
    530                 535                 540                 


Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 
545                 550                 555                 560 


Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly Met 
                565                 570                 575     


Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val Leu 
            580                 585                 590         


Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys Cys 
        595                 600                 605             


Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu Phe 
    610                 615                 620                 


Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys Glu 
625                 630                 635                 640 


Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu Val 
                645                 650                 655     


Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu 
            660                 665                 670         


Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His Pro 
        675                 680                 685             


Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu 
    690                 695                 700                 


Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg Val 
705                 710                 715                 720 


Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser 
                725                 730                 735     


Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Gln Ala Glu 
            740                 745                 750         


Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu Arg 
        755                 760                 765             


Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys Pro 
    770                 775                 780                 


Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala 
785                 790                 795                 800 


Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala 
                805                 810                 815     


Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu 
            820                 825                 830         


Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
        835                 840                 845             


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
    850                 855                 860                 


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
865                 870                 875                 880 


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
                885                 890                 895     


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
            900                 905                 910         


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
        915                 920                 925             


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
    930                 935                 940                 


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
945                 950                 955                 960 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
                965                 970                 975     


Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
            980                 985                 990         


Thr Ala Arg Ile Ser Cys Ser Gly  Asp Ser Leu Arg Asn  Lys Val Tyr 
        995                 1000                 1005             


Trp Tyr  Gln Gln Lys Pro Gly  Gln Ala Pro Val Leu  Val Ile Tyr 
    1010                 1015                 1020             


Lys Asn  Asn Arg Pro Ser Gly  Ile Pro Glu Arg Phe  Ser Gly Ser 
    1025                 1030                 1035             


Asn Ser  Gly Asn Thr Ala Thr  Leu Thr Ile Ser Gly  Thr Gln Ala 
    1040                 1045                 1050             


Glu Asp  Glu Ala Asp Tyr Tyr  Cys Gln Ser Tyr Asp  Gly Gln Lys 
    1055                 1060                 1065             


Ser Leu  Val Phe Gly Gly Gly  Thr Lys Leu Thr Val  Leu Ala Ala 
    1070                 1075                 1080             


Ala 
    


<210>  296
<211>  3252
<212>  DNA
<213>  Homo Sapien

<400>  296
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgacgctcac aagagcgaag tggcacatag gttcaaagat      780

ctgggcgaag agaactttaa ggccctcgtc ctgatcgctt tcgcacagta cctccagcag      840

tctccctttg aagatcacgt gaaactggtc aatgaggtga ccgaatttgc caagacatgc      900

gtggctgatg agagtgcaga aaactgtgac aaatcactgc atactctctt tggagataag      960

ctgtgcaccg tcgccacact cagagagact tatggggaaa tggctgactg ttgcgcaaaa     1020

caggagcctg aacggaatga gtgtttcctc cagcacaagg atgacaaccc aaatctgccc     1080

cgcctcgtgc gacctgaggt cgatgtgatg tgcaccgcct ttcatgacaa cgaagagaca     1140

ttcctgaaga aatacctgta tgaaattgct cgtaggcacc catactttta tgcccccgag     1200

ctcctgttct ttgcaaagag atacaaagct gccttcactg aatgttgcca ggcagctgat     1260

aaggccgcat gtctcctgcc taaactggac gagctccggg atgaaggtaa ggcttccagc     1320

gccaaacagc gcctgaagtg cgcttctctc cagaagtttg gcgagcgagc attcaaagcc     1380

tgggctgtgg cccgtctcag tcagaggttt ccaaaggcag aatttgctga ggtctcaaaa     1440

ctggtgaccg acctcacaaa ggtccatact gagtgttgcc acggagatct gctggaatgt     1500

gccgacgata gagcagacct cgctaaatat atctgcgaga atcaggattc cattagctct     1560

aagctgaaag aatgttgcga gaagcccctc ctggaaaaga gtcattgtat cgccgaggtg     1620

gaaaacgacg agatgccagc agatctgcca tcactcgctg ccgactttgt ggaatccaaa     1680

gatgtctgca agaattacgc agaggctaaa gacgtgttcc tggggatgtt tctgtatgag     1740

tacgcccggc gtcaccccga ttatagcgtc gtgctcctgc tccgactggc aaagacctac     1800

gaaacaactc tggagaaatg ttgcgctgcc gcagaccctc atgaatgtta tgctaaggtg     1860

ttcgatgagt ttaagccact cgtcgaagag ccccagaacc tgattaaaca gaattgcgaa     1920

ctgttcgagc agctcggtga atacaagttt cagaacgccc tgctcgtgcg ttataccaaa     1980

aaggtccctc aggtgtctac accaactctg gtggaggtca gtaggaatct gggcaaagtg     2040

ggatcaaagt gttgcaaaca ccccgaggca aagagaatgc cttgtgctga agattacctc     2100

tccgtcgtgc tgaaccagct ctgcgtgctg catgaaaaga ccccagtcag cgatcgggtg     2160

acaaaatgtt gcaccgaatc tctggtcaat cgccgaccct gtttcagtgc cctcgaagtg     2220

gacgaaactt atgtgcctaa ggagtttcag gctgaaacat tcacctttca cgccgatatc     2280

tgcactctgt ccgagaaaga aaggcagatt aagaaacaga cagcactggt cgagctcgtg     2340

aagcataaac caaaggctac caaggagcag ctgaaagccg tcatggacga tttcgcagct     2400

tttgtggaaa agtgttgcaa agccgacgat aaggagactt gtttcgcaga agaggggaaa     2460

aagctcgtgg ctgccagcca ggcagctctg ggtctgcagg ttcaattggt tgaaagcggt     2520

ggtggtctgg ttcagcctgg tggtagcctg cgtctgagct gtgcagcaag cggttttacc     2580

tttagcgatt atgtgatgaa ttgggttcgt caggcaccgg gtaaaggtct ggaatgggtt     2640

gccggtatta gctggtcagg tgttaatacc cattatgcag atagcgtgaa aggtcgtttt     2700

accattagcc gtgataatag caaaaatacc ctgtatctgc agatgaatag cctgcgtgca     2760

gaagataccg cagtttatta ttgtgcacgt ctgggtgcaa ccgcaaataa tattcgctat     2820

aaatttatgg atgtgtgggg tcagggtaca ctagttaccg ttagcagtgg tggtggcggc     2880

agcggcggtg gcggttccgg cggtggtggc agcggtggtg gtggtagctc ttacgaactg     2940

acccagcctc cgagcgttag cgttgcaccg ggtcagaccg cacgtattag ctgtagcggt     3000

gatagtctgc gtaataaagt ttattggtat cagcagaaac cgggtcaggc tccggttctg     3060

gttatttata aaaataatcg tccgagcggt attccggaac gttttagcgg tagcaatagc     3120

ggtaataccg caaccctgac cattagcggc acccaggcag aagatgaagc cgattattat     3180

tgtcagagct atgatggtca gaaaagcctg gtttttggtg gtggcaccaa gcttaccgtt     3240

ctggcggccg ca                                                         3252


<210>  297
<211>  738
<212>  PRT
<213>  Homo Sapien

<400>  297

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Val Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Gly Ile Ser Trp Ser Gly Val Asn Thr His Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Ala Thr Ala Asn Asn Ile Arg Tyr Lys Phe Met Asp 
            100                 105                 110         


Val Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
    130                 135                 140                 


Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
145                 150                 155                 160 


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Asn Lys Val Tyr 
                165                 170                 175     


Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr Lys 
            180                 185                 190         


Asn Asn Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser Asn Ser 
        195                 200                 205             


Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu Asp Glu 
    210                 215                 220                 


Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Gly Gln Lys Ser Leu Val Phe 
225                 230                 235                 240 


Gly Gly Gly Thr Lys Leu Thr Val Leu Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
465                 470                 475                 480 


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Val Leu Thr 
                485                 490                 495     


Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
            500                 505                 510         


Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg Tyr Leu Ala Trp Tyr 
        515                 520                 525             


Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
    530                 535                 540                 


Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly 
545                 550                 555                 560 


Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro Glu Asp Phe Ala 
                565                 570                 575     


Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro Gln Thr Phe Gly Gln 
            580                 585                 590         


Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        595                 600                 605             


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Lys 
    610                 615                 620                 


Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln Thr Leu Thr Leu Thr 
625                 630                 635                 640 


Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg Gly Gly Gly Val Gly 
                645                 650                 655     


Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu Ala Trp Ile 
            660                 665                 670         


Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser Leu Lys Thr Arg Leu 
        675                 680                 685             


Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu Thr Met Thr 
    690                 695                 700                 


Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala Arg Phe His 
705                 710                 715                 720 


Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
                725                 730                 735     


Ser Ser 
        


<210>  298
<211>  2214
<212>  DNA
<213>  Homo Sapien

<400>  298
caggttcaat tggttgaaag cggtggtggt ctggttcagc ctggtggtag cctgcgtctg       60

agctgtgcag caagcggttt tacctttagc gattatgtga tgaattgggt tcgtcaggca      120

ccgggtaaag gtctggaatg ggttgccggt attagctggt caggtgttaa tacccattat      180

gcagatagcg tgaaaggtcg ttttaccatt agccgtgata atagcaaaaa taccctgtat      240

ctgcagatga atagcctgcg tgcagaagat accgcagttt attattgtgc acgtctgggt      300

gcaaccgcaa ataatattcg ctataaattt atggatgtgt ggggtcaggg tacactagtt      360

accgttagca gtggtggtgg cggcagcggc ggtggcggtt ccggcggtgg tggcagcggt      420

ggtggtggta gcgatatcga actgacccag cctccgagcg ttagcgttgc accgggtcag      480

accgcacgta ttagctgtag cggtgatagt ctgcgtaata aagtttattg gtatcagcag      540

aaaccgggtc aggctccggt tctggttatt tataaaaata atcgtccgag cggtattccg      600

gaacgtttta gcggtagcaa tagcggtaat accgcaaccc tgaccattag cggcacccag      660

gcagaagatg aagccgatta ttattgtcag agctatgatg gtcagaaaag cctggttttt      720

ggtggtggca ccaagcttac cgttctggac aagacccaca cctgcccccc ctgcccagcc      780

ccagaggcag cgggcggacc ctccgtgttc ctgttccccc ccaagcccaa ggacaccctg      840

atgatcagca ggacccccga ggtgacctgc gtggtggtgg acgtgagcca cgaggaccca      900

gaggtgaagt tcaactggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc      960

agagaggagc agtacaacag cacctacagg gtggtgtccg tgctgaccgt gctgcaccag     1020

gactggctga acggcaagga atacaagtgc aaggtctcca acaaggccct gccagccccc     1080

atcgaaaaga ccatcagcaa ggccaagggc cagccacggg agccccaggt gtacaccctg     1140

cccccctccc gggaggagat gaccaagaac caggtgtccc tgacctgtct ggtgaagggc     1200

ttctacccca gcgacatcgc cgtggagtgg gagagcaacg gccagcccga gaacaactac     1260

aagaccaccc ccccagtgct ggacagcgac ggcagcttct tcctgtacag caagctgacc     1320

gtggacaagt ccaggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaagcg     1380

ctgcacaacc actacaccca gaagagcctg agcctgtccc ccggcaaggg aggtggcggg     1440

agtggtggag ggggctcagg cgggggtgga tctgatatcg tgctgacaca gagccctgcc     1500

accctgtctc tgagccctgg cgagagagcc accctgagct gccgggccag ccagttcatc     1560

ggctcccgct acctggcctg gtatcagcag aagcccggac aggctcccag actgctgatc     1620

tacggcgcca gcaacagagc taccggcgtg cccgccagat tttctggcag cggcagcggc     1680

accgacttca ccctgaccat cagcagcctg gaacccgagg acttcgccac ctactactgc     1740

cagcagtact acgactaccc ccagaccttc ggccagggca ccaaggtgga gatcaagggc     1800

ggaggcggat ccgggggtgg cggaagtgga ggcggaggaa gcggaggggg cggaagccag     1860

gtgcaattga aagagtccgg ccctgccctg gtgaagccta cccagaccct gaccctgaca     1920

tgcaccttca gcggcttcag cctgagcaac agaggcggcg gagtgggctg gatcagacag     1980

cctcccggca aggccctgga atggctggcc tggatcgact gggacgacga caagagctac     2040

agcaccagcc tgaaaacccg gctgaccatc tccaaggaca ccagcaagaa ccaggtggtg     2100

ctcaccatga ccaacatgga ccccgtggac accgccacct attattgcgc ccggtttcat     2160

ctgcccctgg tgttcgatag ctggggccag ggaaccctgg tgacagtgtc cagc           2214


<210>  299
<211>  738
<212>  PRT
<213>  Homo Sapien

<400>  299

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Phe Ile Gly Ser Arg 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Asn Arg Ala Thr Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Asp Tyr Pro 
                85                  90                  95      


Gln Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gly Gly Gly Gly 
            100                 105                 110         


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        115                 120                 125             


Gln Val Gln Leu Lys Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 
    130                 135                 140                 


Thr Leu Thr Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Asn Arg 
145                 150                 155                 160 


Gly Gly Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu 
                165                 170                 175     


Trp Leu Ala Trp Ile Asp Trp Asp Asp Asp Lys Ser Tyr Ser Thr Ser 
            180                 185                 190         


Leu Lys Thr Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val 
        195                 200                 205             


Val Leu Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr 
    210                 215                 220                 


Cys Ala Arg Phe His Leu Pro Leu Val Phe Asp Ser Trp Gly Gln Gly 
225                 230                 235                 240 


Thr Leu Val Thr Val Ser Ser Asp Lys Thr His Thr Cys Pro Pro Cys 
                245                 250                 255     


Pro Ala Pro Glu Ala Ala Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            260                 265                 270         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        275                 280                 285             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    290                 295                 300                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
305                 310                 315                 320 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                325                 330                 335     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            340                 345                 350         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        355                 360                 365             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    370                 375                 380                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
385                 390                 395                 400 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                405                 410                 415     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            420                 425                 430         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        435                 440                 445             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    450                 455                 460                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly 
465                 470                 475                 480 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Val Gln Leu Val Glu Ser 
                485                 490                 495     


Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala 
            500                 505                 510         


Ala Ser Gly Phe Thr Phe Ser Asp Tyr Val Met Asn Trp Val Arg Gln 
        515                 520                 525             


Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Gly Ile Ser Trp Ser Gly 
    530                 535                 540                 


Val Asn Thr His Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser 
545                 550                 555                 560 


Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg 
                565                 570                 575     


Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Leu Gly Ala Thr Ala 
            580                 585                 590         


Asn Asn Ile Arg Tyr Lys Phe Met Asp Val Trp Gly Gln Gly Thr Leu 
        595                 600                 605             


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    610                 615                 620                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Glu Leu Thr Gln Pro 
625                 630                 635                 640 


Pro Ser Val Ser Val Ala Pro Gly Gln Thr Ala Arg Ile Ser Cys Ser 
                645                 650                 655     


Gly Asp Ser Leu Arg Asn Lys Val Tyr Trp Tyr Gln Gln Lys Pro Gly 
            660                 665                 670         


Gln Ala Pro Val Leu Val Ile Tyr Lys Asn Asn Arg Pro Ser Gly Ile 
        675                 680                 685             


Pro Glu Arg Phe Ser Gly Ser Asn Ser Gly Asn Thr Ala Thr Leu Thr 
    690                 695                 700                 


Ile Ser Gly Thr Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser 
705                 710                 715                 720 


Tyr Asp Gly Gln Lys Ser Leu Val Phe Gly Gly Gly Thr Lys Leu Thr 
                725                 730                 735     


Val Leu 
        


<210>  300
<211>  2214
<212>  DNA
<213>  Homo Sapien

<400>  300
gatatcgtgc tgacacagag ccctgccacc ctgtctctga gccctggcga gagagccacc       60

ctgagctgcc gggccagcca gttcatcggc tcccgctacc tggcctggta tcagcagaag      120

cccggacagg ctcccagact gctgatctac ggcgccagca acagagctac cggcgtgccc      180

gccagatttt ctggcagcgg cagcggcacc gacttcaccc tgaccatcag cagcctggaa      240

cccgaggact tcgccaccta ctactgccag cagtactacg actaccccca gaccttcggc      300

cagggcacca aggtggagat caagggcgga ggcggaagcg ggggtggcgg aagtggaggc      360

ggaggaagcg gagggggcgg aagccaggtg caattgaaag agtccggccc tgccctggtg      420

aagcctaccc agaccctgac cctgacatgc accttcagcg gcttcagcct gagcaacaga      480

ggcggcggag tgggctggat cagacagcct cccggcaagg ccctggaatg gctggcctgg      540

atcgactggg acgacgacaa gagctacagc accagcctga aaacccggct gaccatctcc      600

aaggacacca gcaagaacca ggtggtgctc accatgacca acatggaccc cgtggacacc      660

gccacctatt attgcgcccg gtttcatctg cccctggtgt tcgatagctg gggccaggga      720

accctggtga cagtgtccag cgacaagacc cacacctgcc ccccctgccc agccccagag      780

gcagcgggcg gaccctccgt gttcctgttc ccccccaagc ccaaggacac cctgatgatc      840

agcaggaccc ccgaggtgac ctgcgtggtg gtggacgtga gccacgagga cccagaggtg      900

aagttcaact ggtacgtgga cggcgtggag gtgcacaacg ccaagaccaa gcccagagag      960

gagcagtaca acagcaccta cagggtggtg tccgtgctga ccgtgctgca ccaggactgg     1020

ctgaacggca aggaatacaa gtgcaaggtc tccaacaagg ccctgccagc ccccatcgaa     1080

aagaccatca gcaaggccaa gggccagcca cgggagcccc aggtgtacac cctgcccccc     1140

tcccgggagg agatgaccaa gaaccaggtg tccctgacct gtctggtgaa gggcttctac     1200

cccagcgaca tcgccgtgga gtgggagagc aacggccagc ccgagaacaa ctacaagacc     1260

acccccccag tgctggacag cgacggcagc ttcttcctgt acagcaagct gaccgtggac     1320

aagtccaggt ggcagcaggg caacgtgttc agctgcagcg tgatgcacga agcgctgcac     1380

aaccactaca cccagaagag cctgagcctg tcccccggca agggaggtgg cgggagtggt     1440

ggagggggct caggcggggg tggatctcag gttcaattgg ttgaaagcgg tggtggtctg     1500

gttcagcctg gtggtagcct gcgtctgagc tgtgcagcaa gcggttttac ctttagcgat     1560

tatgtgatga attgggttcg tcaggcaccg ggtaaaggtc tggaatgggt tgccggtatt     1620

agctggtcag gtgttaatac ccattatgca gatagcgtga aaggtcgttt taccattagc     1680

cgtgataata gcaaaaatac cctgtatctg cagatgaata gcctgcgtgc agaagatacc     1740

gcagtttatt attgtgcacg tctgggtgca accgcaaata atattcgcta taaatttatg     1800

gatgtgtggg gtcagggtac actagttacc gttagcagtg gtggtggtgg tagcggtggt     1860

ggcggatctg gtggcggtgg ttcaggtggt ggtggcagtg atatcgaact gacccagcct     1920

ccgagcgtta gcgttgcacc gggtcagacc gcacgtatta gctgtagcgg tgatagtctg     1980

cgtaataaag tttattggta tcagcagaaa ccgggtcagg ctccggttct ggttatttat     2040

aaaaataatc gtccgagcgg tattccggaa cgttttagcg gtagcaatag cggtaatacc     2100

gcaaccctga ccattagcgg cacccaggca gaagatgaag ccgattatta ttgtcagagc     2160

tatgatggtc agaaaagcct ggtttttggt ggtggcacca agcttaccgt tctg           2214


<210>  301
<211>  53
<212>  DNA
<213>  Homo Sapien

<400>  301
gctacgtcgc gattctggaa ggcgtgcact gtcaggtgca attggtggaa agc              53


<210>  302
<211>  30
<212>  DNA
<213>  Homo Sapien

<400>  302
gctacggcta gctgagctaa ccgtcaccag                                        30


<210>  303
<211>  33
<212>  DNA
<213>  Homo Sapien

<400>  303
gctacgaccg gtgatatcga actgacccag ccg                                    33


<210>  304
<211>  28
<212>  DNA
<213>  Homo Sapien

<400>  304
gctacgaagc ttcgtgccgc cgccaaac                                          28


<210>  305
<211>  33
<212>  DNA
<213>  Homo Sapien

<400>  305
cagtacctgc agaagtccag ctacgacgag cac                                    33


<210>  306
<211>  33
<212>  DNA
<213>  Homo Sapien

<400>  306
gtgctcgtcg tagctggact tctgcaggta ctg                                    33


<210>  307
<211>  23
<212>  DNA
<213>  Homo Sapien

<400>  307
ggcccacaag agcgagatcg ccc                                               23


<210>  308
<211>  78
<212>  DNA
<213>  Homo Sapien

<400>  308
gcggccgccc ggcgcgcctc atcagtgatg gtgatgatgg tgggccaggg cgtccttgga       60

ccgggtcacc aggttggg                                                     78


<210>  309
<211>  36
<212>  DNA
<213>  Homo Sapien

<400>  309
tgtcaggtgc aattggtcga gtctggcgga ggactg                                 36


<210>  310
<211>  20
<212>  DNA
<213>  Homo Sapien

<400>  310
ccttggtgct ggctgagctg                                                   20


<210>  311
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  311
gcttccggac accaccggtg acatcgagct gacccagcc                              39


<210>  312
<211>  36
<212>  DNA
<213>  Homo Sapien

<400>  312
cagcacggta agcttggtgc ctccgccgaa caccag                                 36


<210>  313
<211>  53
<212>  DNA
<213>  Homo Sapien

<400>  313
gctacgtcgc gattctggaa ggcgtgcact gtcaggtgca attggtggaa agc              53


<210>  314
<211>  30
<212>  DNA
<213>  Homo Sapien

<400>  314
gctacggcta gctgagctaa ccgtcaccag                                        30


<210>  315
<211>  31
<212>  DNA
<213>  Homo Sapien

<400>  315
ggtccaactg cacggtagct ttctagagcc g                                      31


<210>  316
<211>  31
<212>  DNA
<213>  Homo Sapien

<400>  316
cggctctaga aagctaccgt gcagttggac c                                      31


<210>  317
<211>  27
<212>  DNA
<213>  Homo Sapien

<400>  317
gcggaacaaa gcttaccgtg ctgggcc                                           27


<210>  318
<211>  27
<212>  DNA
<213>  Homo Sapien

<400>  318
ggcccagcac ggtaagcttt gttccgc                                           27


<210>  319
<211>  33
<212>  DNA
<213>  Homo Sapien

<400>  319
gctacgaccg gtgatatcga actgacccag ccg                                    33


<210>  320
<211>  28
<212>  DNA
<213>  Homo Sapien

<400>  320
gctacgaagc ttcgtgccgc cgccaaac                                          28


<210>  321
<211>  29
<212>  DNA
<213>  Homo Sapien

<400>  321
ggccagggca cacttgtgac cgtcagctc                                         29


<210>  322
<211>  29
<212>  DNA
<213>  Homo Sapien

<400>  322
gagctgacgg tcacaagtgt gccctggcc                                         29


<210>  323
<211>  80
<212>  DNA
<213>  Homo Sapien

<400>  323
ggccccaacc tggtgacccg gtccaaggac gccctggccg gcggctccgg cggaagcgat       60

atcgtgctga cacagagccc                                                   80


<210>  324
<211>  64
<212>  DNA
<213>  Homo Sapien

<400>  324
gtttaaacgg gccctctaga gcggccgccc ggcgcgcctc agctggacac tgtcaccagg       60

gttc                                                                    64


<210>  325
<211>  32
<212>  DNA
<213>  Homo Sapien

<400>  325
gcggccagtc aggcagcgct tggtttgtga tg                                     32


<210>  326
<211>  32
<212>  DNA
<213>  Homo Sapien

<400>  326
catcacaaac caagcgctgc ctgactggcc gc                                     32


<210>  327
<211>  43
<212>  DNA
<213>  Homo Sapien

<400>  327
caggcagcgc ttggtttggg cggctccggc ggaagcgata tcg                         43


<210>  328
<211>  24
<212>  DNA
<213>  Homo Sapien

<400>  328
gggtttaaac gggccctcta gagc                                              24


<210>  329
<211>  58
<212>  DNA
<213>  Homo Sapien

<400>  329
caggcagcgc ttggtttggg cggctccggc ggaagcgata tcgtgctgac ccagagcc         58


<210>  330
<211>  59
<212>  DNA
<213>  Homo Sapien

<400>  330
gccctctaga gcggccgccc ggcgcgcctc atcagcagct cttgggctcc actctcttg        59


<210>  331
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  331
caagacccac accggccccc ccggcccagc cccagaggc                              39


<210>  332
<211>  39
<212>  DNA
<213>  Homo Sapien

<400>  332
gcctctgggg ctgggccggg ggggccggtg tgggtcttg                              39


<210>  333
<211>  35
<212>  DNA
<213>  Homo Sapien

<400>  333
gcgacggcag cttcaccctg gacagcaagc tgacc                                  35


<210>  334
<211>  35
<212>  DNA
<213>  Homo Sapien

<400>  334
ggtcagcttg ctgtccaggg tgaagctgcc gtcgc                                  35


<210>  335
<211>  40
<212>  DNA
<213>  Homo Sapien

<400>  335
ccgttgcgcc gactgaggcc tgctgataag catgcgtagg                             40


<210>  336
<211>  40
<212>  DNA
<213>  Homo Sapien

<400>  336
cctacgcatg cttatcagca ggcctcagtc ggcgcaacgg                             40


