                               SEQUENCE LISTING

<110> BRISTOL-MYERS SQUIBB COMPANY
 
<120> FIBRONECTIN BINDING DOMAINS WITH REDUCED IMMUNOGENICITY

<130> MXI-527PC

<140>
<141>

<150> 61/553,878
<151> 2011-10-31

<160> 72    

<170> PatentIn version 3.5

<210> 1
<211> 101
<212> PRT
<213> Homo sapiens

<400> 1
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile 
                85                  90                  95      


Asp Lys Pro Ser Gln 
            100     


<210> 2
<211> 85
<212> PRT
<213> Homo sapiens

<400> 2
Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp 
1               5                   10                  15      


Ala Pro Ala Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr 
            20                  25                  30          


Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser 
        35                  40                  45              


Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr 
    50                  55                  60                  


Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro 
65                  70                  75                  80  


Ile Ser Ile Asn Tyr 
                85  


<210> 3
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 3
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Gln His Ser Lys Tyr Pro His Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Ile Gln 
65                  70                  75                  80  


Pro Gln Asp Pro Glu Gln Asp Tyr Gln Tyr His Tyr Tyr Glu Thr Ser 
                85                  90                  95      


Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser 
            100                 105                 110         


Gln 
    


<210> 4
<211> 115
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 4
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu His Val Ala Asp His Phe Asp His 
        35                  40                  45              


Asn Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser 
    50                  55                  60                  


Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr 
65                  70                  75                  80  


Tyr Gln Phe Gln Asp Pro Glu Glu His Tyr Tyr Tyr His Phe Tyr Asp 
                85                  90                  95      


Ser Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys 
            100                 105                 110         


Pro Ser Gln 
        115 


<210> 5
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 5
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Tyr His Glu His Tyr His Ser Pro 
        35                  40                  45              


Gly Phe Ser Gln Lys Tyr His Tyr Glu Gln Glu Phe Thr Val Pro Gly 
    50                  55                  60                  


Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr 
65                  70                  75                  80  


Thr Ile Thr Val Tyr Ala Val Thr Gly His Lys His Tyr His Tyr Tyr 
                85                  90                  95      


Tyr Tyr Tyr His His His Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg 
            100                 105                 110         


Thr Glu Ile Asp Lys Pro Ser Gln 
        115                 120 


<210> 6
<211> 94
<212> PRT
<213> Homo sapiens

<400> 6
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210> 7
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 7
Glu Ile Glu Lys 
1               


<210> 8
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 8
Glu Ile Glu Lys Pro Cys 
1               5       


<210> 9
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 9
Met Gly Val Ser Asp Val Pro Arg Asp Leu 
1               5                   10  


<210> 10
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 10
Val Ser Asp Val Pro Arg Asp Leu 
1               5               


<210> 11
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 11
Gly Val Ser Asp Val Pro Arg Asp Leu 
1               5                   


<210> 12
<211> 94
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 12
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  


<210> 13
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 13
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Ser Arg Pro Lys Gly Ser Ile Lys 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Asn Ser Gln Tyr Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Tyr 
65                  70                  75                  80  


Pro Tyr Gln Glu Pro His Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln His His His His His His 
            100                 105                 


<210> 14
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 14
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Thr Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Gly Pro Lys Tyr Tyr Val Lys 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Arg Thr Asp His Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Lys Gly Gln 
65                  70                  75                  80  


Tyr Gly Pro Tyr Tyr Gly Ser Arg Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln His His His His His His 
            100                 105                 


<210> 15
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 15
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Ser Gln Pro Gly Arg Tyr Val Lys 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Asn Asp Thr Tyr Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Lys 
65                  70                  75                  80  


Tyr Gly Pro Tyr Tyr Gly Tyr Asp Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln His His His His His His 
            100                 105                 


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220> 
<221> misc_feature
<222> (1)..(16)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 16
Met Gly Ser Asp Val Pro Arg Asp Leu 
1               5                   


<210> 17
<211> 8
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220> 
<221> misc_feature
<222> (1)..(8)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 17
Met Gly Asp Val Pro Arg Asp Leu 
1               5               


<210> 18
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220> 
<221> misc_feature
<222> (1)..(7)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 18
Met Gly Val Pro Arg Asp Leu 
1               5           


<210> 19
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220> 
<221> misc_feature
<222> (1)..(6)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 19
Met Gly Pro Arg Asp Leu 
1               5       


<210> 20
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220> 
<221> misc_feature
<222> (1)..(5)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 20
Met Gly Arg Asp Leu 
1               5   


<210> 21
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"


<220>
<221> VARIANT
<222> (1)..(2)
<223> /replace=" "

<220>
<221> misc_feature
<222> (1)..(2)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220> 
<221> misc_feature
<222> (1)..(4)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 21
Met Gly Asp Leu 
1               


<210> 22
<211> 166
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      10Fn3 domain core sequence version 3"


<220>
<221> MOD_RES
<222> (14)..(33)
<223> Any amino acid

<220>
<221> VARIANT
<222> (16)..(33)
<223> /replace=" "

<220>
<221> misc_feature
<222> (16)..(33)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> misc_feature
<222> (14)..(33)
<223> /note="This region may encompass 2 to 20 residues"

<220>
<221> MOD_RES
<222> (39)..(58)
<223> Any amino acid

<220>
<221> VARIANT
<222> (41)..(58)
<223> /replace=" "

<220>
<221> misc_feature
<222> (41)..(58)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> misc_feature
<222> (39)..(58)
<223> /note="This region may encompass 2 to 20 residues"

<220>
<221> MOD_RES
<222> (64)..(83)
<223> Any amino acid

<220>
<221> VARIANT
<222> (66)..(83)
<223> /replace=" "

<220>
<221> misc_feature
<222> (66)..(83)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> misc_feature
<222> (64)..(83)
<223> /note="This region may encompass 2 to 20 residues"

<220>
<221> MOD_RES
<222> (87)..(106)
<223> Any amino acid

<220>
<221> VARIANT
<222> (89)..(106)
<223> /replace=" "

<220>
<221> misc_feature
<222> (89)..(106)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> misc_feature
<222> (87)..(106)
<223> /note="This region may encompass 2 to 20 residues"

<220>
<221> MOD_RES
<222> (113)..(132)
<223> Any amino acid

<220>
<221> VARIANT
<222> (115)..(132)
<223> /replace=" "

<220>
<221> misc_feature
<222> (115)..(132)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> misc_feature
<222> (113)..(132)
<223> /note="This region may encompass 2 to 20 residues"

<220>
<221> MOD_RES
<222> (140)..(159)
<223> Any amino acid

<220>
<221> VARIANT
<222> (142)..(159)
<223> /replace=" "

<220>
<221> misc_feature
<222> (142)..(159)
<223> /note="Residues given in the sequence have no preference 
      with respect to those in the annotations for said positions"

<220>
<221> misc_feature
<222> (140)..(159)
<223> /note="This region may encompass 2 to 20 residues"

<220> 
<221> misc_feature
<222> (1)..(166)
<223> /note="see specification as filed for detailed description of
      substitutions and preferred embodiments"

<400> 22
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Leu Leu Ile Ser Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Arg Ile Thr Tyr Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Phe Thr Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Thr Ile Ser Gly Leu 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Tyr Thr Ile Thr Val Tyr Ala Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ile 
145                 150                 155                 160 


Ser Ile Asn Tyr Arg Thr 
                165     


<210> 23
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 23
Glu Gly Ser Gly Cys 
1               5   


<210> 24
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 24
Glu Ile Glu Lys Pro Cys Gln 
1               5           


<210> 25
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 25
Glu Ile Glu Lys Pro Ser Gln 
1               5           


<210> 26
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 26
Glu Ile Glu Lys Pro 
1               5   


<210> 27
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 27
Glu Ile Glu Lys Pro Ser 
1               5       


<210> 28
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 28
Glu Gly Ser Gly Ser 
1               5   


<210> 29
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 29
Glu Ile Asp Lys 
1               


<210> 30
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 30
Glu Ile Asp Lys Pro Ser Gln 
1               5           


<210> 31
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 31
Glu Ile Asp Lys Pro Cys Gln 
1               5           


<210> 32
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 32
Pro Ser Thr Ser Thr Ser Thr 
1               5           


<210> 33
<211> 3
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 33
Gly Pro Gly 
1           


<210> 34
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 34
Gly Pro Gly Pro Gly Pro Gly 
1               5           


<210> 35
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 35
Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly 
1               5                   10      


<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 36
Pro Ala Pro Ala Pro Ala 
1               5       


<210> 37
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 37
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
1               5                   10          


<210> 38
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 38
Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala Pro Ala 
1               5                   10                  15      


Pro Ala 
        


<210> 39
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 39
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10  


<210> 40
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 40
Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Gly Ser 
            20  


<210> 41
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 41
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210> 42
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 42
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25  


<210> 43
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 43
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly 
1               5                   10                  15  


<210> 44
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      6xHis tag"

<400> 44
His His His His His His 
1               5       


<210> 45
<211> 116
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 45
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Tyr His Ala Phe Phe Ala Ser Asn 
        35                  40                  45              


Gly Lys Tyr Tyr Phe Tyr Ile Gln Glu Phe Thr Val Pro Gly Ser Lys 
    50                  55                  60                  


Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 
65                  70                  75                  80  


Thr Val Tyr Ala Val Thr Asp Asp Thr Val His His Gly Asp Ser Asn 
                85                  90                  95      


Tyr His Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp 
            100                 105                 110         


Lys Pro Ser Gln 
        115     


<210> 46
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 46
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Tyr Ser Ser Phe Phe Gln His Gln 
        35                  40                  45              


Gly Gln Tyr Tyr His Tyr Ile Gln Glu Phe Thr Val Pro Gly Ser Lys 
    50                  55                  60                  


Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 
65                  70                  75                  80  


Thr Val Tyr Ala Val Thr Gln His Glu His Ser Gln Asp Ser Ser Lys 
                85                  90                  95      


Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser Gln 
            100                 105                 110     


<210> 47
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 47
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Phe Ser Gln Phe Val His Ser Asp 
        35                  40                  45              


Gly Glu Tyr Tyr Gln Glu Tyr Gln Glu Phe Thr Val Pro Gly Ser Lys 
    50                  55                  60                  


Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile 
65                  70                  75                  80  


Thr Val Tyr Ala Val Thr Gly Gln Tyr Asp Gln Asp Asp Glu Pro Ser 
                85                  90                  95      


Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys Pro Ser 
            100                 105                 110         


Gln 
    


<210> 48
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 48
Met Ala Ser Thr Ser Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val 
1               5                   10                  15      


Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            20                  25                  30          


Val Pro Val Ser Lys Tyr Val Ile Tyr Tyr Trp Pro Gly Ala Leu Ile 
        35                  40                  45              


Ser Ser Met Gln Ala Phe Lys Val Pro Gly Ser Lys Ser Thr Ala Thr 
    50                  55                  60                  


Ile Ser Gly Leu Lys Pro Gly Val Leu Tyr Ser Ile Val Val Asp Ala 
65                  70                  75                  80  


Leu Thr Gly Asp Gly Gln Gly Ser Tyr Val Trp Asp Pro Ile Thr Ile 
                85                  90                  95      


Thr Tyr Arg Thr Glu Gly Ser Gly Ser 
            100                 105 


<210> 49
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 49
Met Ala Ser Thr Ser Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val 
1               5                   10                  15      


Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            20                  25                  30          


Val Thr Val His Ser Tyr Tyr Ile Thr Tyr Gln Glu Leu Gln His His 
        35                  40                  45              


Ser Val Pro Gln Gly Phe Gln Val Pro Gly Ser Lys Ser Thr Ala Thr 
    50                  55                  60                  


Ile Ser Gly Leu Lys Pro Gly Val Ala Tyr Gln Ile Ala Val Tyr Ala 
65                  70                  75                  80  


Phe Thr Gly Pro Gly Leu Pro Pro Ser Asp Ala Pro Pro Ile Val Ile 
                85                  90                  95      


Tyr Tyr Arg Thr Glu Gly Ser Gly Ser 
            100                 105 


<210> 50
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 50
Met Ala Ser Thr Ser Gly 
1               5       


<210> 51
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 51
Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile 
1               5                   10                  15      


Ser Gly Leu Lys 
            20  


<210> 52
<211> 26
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 52
Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser 
1               5                   10                  15      


Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr 
            20                  25      


<210> 53
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 53
Met Gly Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser 
1               5                   10                  15  


<210> 54
<211> 19
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 54
Pro His Phe Pro Thr Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
1               5                   10                  15      


Gly Asn Ser 
            


<210> 55
<211> 23
<212> PRT
<213> Homo sapiens

<400> 55
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
1               5                   10                  15      


Tyr Tyr Arg Ile Thr Tyr Gly 
            20              


<210> 56
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 56
Pro Thr Ser Leu Leu Ile Ser Trp Ser Ala Arg Leu Lys Val Ala Arg 
1               5                   10                  15      


Tyr Tyr Arg Ile Thr Tyr Gly 
            20              


<210> 57
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 57
Pro Thr Ser Leu Leu Ile Ser Trp Arg His Pro His Phe Pro Thr Arg 
1               5                   10                  15      


Tyr Tyr Arg Ile Thr Tyr Gly 
            20              


<210> 58
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      peptide"

<400> 58
Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg 
1               5                   10                  15      


Tyr Tyr Arg Ile Thr Tyr Gly 
            20              


<210> 59
<211> 101
<212> PRT
<213> Homo sapiens

<400> 59
Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro Thr 
1               5                   10                  15      


Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala Val Thr Val Arg Tyr Tyr 
            20                  25                  30          


Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe 
        35                  40                  45              


Thr Val Pro Gly Ser Lys Ser Thr Ala Thr Ile Ser Gly Leu Lys Pro 
    50                  55                  60                  


Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Gly Arg Gly Glu 
65                  70                  75                  80  


Ser Pro Ala Ser Ser Lys Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile 
                85                  90                  95      


Asp Lys Pro Ser Gln 
            100     


<210> 60
<211> 86
<212> PRT
<213> Homo sapiens

<400> 60
Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala 
1               5                   10                  15      


Pro Ala Val Thr Val Arg Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly 
            20                  25                  30          


Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Gly Ser Lys Ser Thr 
        35                  40                  45              


Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr Ile Thr Val 
    50                  55                  60                  


Tyr Ala Val Thr Gly Arg Gly Asp Ser Pro Ala Ser Ser Lys Pro Ile 
65                  70                  75                  80  


Ser Ile Asn Tyr Arg Thr 
                85      


<210> 61
<211> 98
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 61
Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr Pro 
1               5                   10                  15      


Thr Ser Leu Leu Ile Ser Trp Ser Ala Arg Leu Lys Val Ala Arg Tyr 
            20                  25                  30          


Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln Glu 
        35                  40                  45              


Phe Thr Val Pro Lys Asn Val Tyr Thr Ala Thr Ile Ser Gly Leu Lys 
    50                  55                  60                  


Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Thr Arg Phe Arg 
65                  70                  75                  80  


Asp Tyr Gln Pro Ile Ser Ile Asn Tyr Arg Thr Glu Ile Asp Lys Pro 
                85                  90                  95      


Ser Gln 
        


<210> 62
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 62
Met Ala Ser Thr Ser Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val 
1               5                   10                  15      


Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            20                  25                  30          


Val Pro Val Ser Lys Tyr Val Ile Tyr Tyr Trp Pro Gly Ala Leu Ile 
        35                  40                  45              


Ser Ser Met Gln Ala Phe Lys Val Pro Gly Ser Lys Ser Thr Ala Thr 
    50                  55                  60                  


Ile Ser Gly Leu Lys Pro Gly Val Leu Tyr Ser Ile Val Val Asp Ala 
65                  70                  75                  80  


Leu Thr Gly Asp Gly Gln Gly Ser Tyr Val Trp Asp Pro Ile Thr Ile 
                85                  90                  95      


Thr Tyr Arg Thr Glu Gly Ser Gly Ser His His His His His His 
            100                 105                 110     


<210> 63
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 63
Met Ala Ser Thr Ser Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val 
1               5                   10                  15      


Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            20                  25                  30          


Val Thr Val His Ser Tyr Tyr Ile Thr Tyr Gln Glu Leu Gln His His 
        35                  40                  45              


Ser Val Pro Gln Gly Phe Gln Val Pro Gly Ser Lys Ser Thr Ala Thr 
    50                  55                  60                  


Ile Ser Gly Leu Lys Pro Gly Val Ala Tyr Gln Ile Ala Val Tyr Ala 
65                  70                  75                  80  


Phe Thr Gly Pro Gly Leu Pro Pro Ser Asp Ala Pro Pro Ile Val Ile 
                85                  90                  95      


Tyr Tyr Arg Thr Glu Gly Ser Gly Ser His His His His His His 
            100                 105                 110     


<210> 64
<211> 114
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 64
Met Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys Gly Thr Ala Asp 
1               5                   10                  15      


Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Pro 
            20                  25                  30          


Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg Ile Thr Tyr Gly 
        35                  40                  45              


Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Tyr Trp 
    50                  55                  60                  


Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr 
65                  70                  75                  80  


Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro Trp Ala Gly Gln 
                85                  90                  95      


Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg Thr Glu Gly Ser 
            100                 105                 110         


Gly Ser 
        


<210> 65
<211> 105
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 65
Met Ala Ser Thr Ser Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val 
1               5                   10                  15      


Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            20                  25                  30          


Val Thr Val Asn Asn Tyr Arg Ile Thr Tyr Gln Pro Leu Leu Gln Gly 
        35                  40                  45              


Ser Ser Ile Gln His Phe Asp Val Pro Gly Ser Lys Ser Thr Ala Thr 
    50                  55                  60                  


Ile Ser Gly Leu Lys Pro Gly Val Gly Tyr Gln Ile Thr Val Tyr Ala 
65                  70                  75                  80  


Ser Thr Tyr Thr His Ser Lys Ala Tyr Tyr Ser Leu Pro Ile Ser Ile 
                85                  90                  95      


Tyr Tyr Arg Thr Glu Gly Ser Gly Ser 
            100                 105 


<210> 66
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 66
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Lys Tyr Pro Tyr Glu Thr Ile Ser 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Tyr Tyr Arg Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Glu Ala Ser 
65                  70                  75                  80  


Ala Pro Tyr Ser Asp Gly Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln 
            100             


<210> 67
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 67
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Ser Arg Pro Lys Gly Ser Ile Lys 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Asn Ser Gln Tyr Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Tyr 
65                  70                  75                  80  


Pro Tyr Gln Glu Pro His Tyr Tyr Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln 
            100             


<210> 68
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 68
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Thr Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Asp Gly Pro Lys Tyr Tyr Val Lys 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Arg Thr Asp His Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Lys Gly Gln 
65                  70                  75                  80  


Tyr Gly Pro Tyr Tyr Gly Ser Arg Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln 
            100             


<210> 69
<211> 103
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 69
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Ser Gln Pro Gly Arg Tyr Val Lys 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Asn Asp Thr Tyr Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Tyr Gly Lys 
65                  70                  75                  80  


Tyr Gly Pro Tyr Tyr Gly Tyr Asp Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln 
            100             


<210> 70
<211> 120
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 70
Met Ala Ser Thr Ser Gly Ser Thr His Tyr Tyr Lys Gly Thr Ala Asp 
1               5                   10                  15      


Leu Glu Val Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Pro 
            20                  25                  30          


Pro Pro Tyr Tyr Val Glu Gly Val Thr Val Phe Arg Ile Thr Tyr Gly 
        35                  40                  45              


Glu Thr Gly Gly Asn Ser Pro Val Gln Glu Phe Thr Val Pro Tyr Trp 
    50                  55                  60                  


Thr Glu Thr Ala Thr Ile Ser Gly Leu Lys Pro Gly Val Asp Tyr Thr 
65                  70                  75                  80  


Ile Thr Val Tyr Ala Glu Met Tyr Pro Gly Ser Pro Trp Ala Gly Gln 
                85                  90                  95      


Val Met Asp Ile Gln Pro Ile Ser Ile Asn Tyr Arg Thr Glu Gly Ser 
            100                 105                 110         


Gly Ser His His His His His His 
        115                 120 


<210> 71
<211> 111
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 71
Met Ala Ser Thr Ser Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val 
1               5                   10                  15      


Val Ala Ala Thr Pro Thr Ser Leu Leu Ile Ser Trp Asp Ala Pro Ala 
            20                  25                  30          


Val Thr Val Asn Asn Tyr Arg Ile Thr Tyr Gln Pro Leu Leu Gln Gly 
        35                  40                  45              


Ser Ser Ile Gln His Phe Asp Val Pro Gly Ser Lys Ser Thr Ala Thr 
    50                  55                  60                  


Ile Ser Gly Leu Lys Pro Gly Val Gly Tyr Gln Ile Thr Val Tyr Ala 
65                  70                  75                  80  


Ser Thr Tyr Thr His Ser Lys Ala Tyr Tyr Ser Leu Pro Ile Ser Ile 
                85                  90                  95      


Tyr Tyr Arg Thr Glu Gly Ser Gly Ser His His His His His His 
            100                 105                 110     


<210> 72
<211> 109
<212> PRT
<213> Artificial Sequence

<220>
<221> source
<223> /note="Description of Artificial Sequence: Synthetic
      polypeptide"

<400> 72
Met Gly Val Ser Asp Val Pro Arg Asp Leu Glu Val Val Ala Ala Thr 
1               5                   10                  15      


Pro Thr Ser Leu Leu Ile Ser Trp Lys Tyr Pro Tyr Glu Thr Ile Ser 
            20                  25                  30          


Tyr Tyr Arg Ile Thr Tyr Gly Glu Thr Gly Gly Asn Ser Pro Val Gln 
        35                  40                  45              


Glu Phe Thr Val Pro Tyr Tyr Arg Ser Thr Ala Thr Ile Ser Gly Leu 
    50                  55                  60                  


Lys Pro Gly Val Asp Tyr Thr Ile Thr Val Tyr Ala Val Glu Ala Ser 
65                  70                  75                  80  


Ala Pro Tyr Ser Asp Gly Gly Ser Pro Ile Ser Ile Asn Tyr Arg Thr 
                85                  90                  95      


Glu Ile Asp Lys Pro Ser Gln His His His His His His 
            100                 105                 


