                         SEQUENCE LISTING

<110>  Chen, Ming-Tang
       Choi, Byung-Kwon
 
<120>  ENGINEERED PICHIA STRAINS WITH IMPROVED FERMENTATION YIELD AND 
       N-GLYCOSYLATION QUALITY

<130>  23147

<150>  US 61/553,801
<151>  2011-10-31

<160>  98    

<170>  PatentIn version 3.5

<210>  1
<211>  1219
<212>  DNA
<213>  Pichia pastoris

<400>  1
tgaatggcct gactaacaga agaatatttg ttttccagga agttaatgtc tcttggaact       60

gattcaatta gttctttgtg gtttgcttga tcgtctttca agctctctgc gatgtccatt      120

tgctgctgaa tgtactgatc aagttgttct atttcttttt gataggcatc tggtagatcc      180

gtgactctcg taagggatgt tatctgtggt tgagaagcat tgttagggtt gttgggtgct      240

gcattgttgc ccagtaaact attattgtta ttacttgaat tgaaaagccc accagcatta      300

ctgttagtat tgtttccaaa tagactccct gtagttgtat tagcgttcgt attattgctc      360

ccaaaaagac ctccagtgtt accactcgga ttatttgagc ctgagaaacc actttgtgca      420

ggtttattgg catttccaaa caacccccct ccagtttggg cattactatt tgcagtattg      480

ctgcctccaa aaagaccacc cgattgtgtg ttatttgaat tggttccaaa tagccctcct      540

gattgtgtgt taccagaatt tcctccaaat aatcctccct gttgagtgtt agagttagtg      600

ttggtgttac ctccaaagag tcctttcgat tgagtattac tagcatttcc cccaaacaac      660

cctcctgatt gattgctgtt gctagcagta ttcccaccaa acaatccttg cgattgagta      720

tttcccgtgt tggtgttggc gccaaataag ctacctgact gattcgtgtt ggtattacca      780

gaattgtttc caaacatacc gcctgtattg gtactacctg aagcgttcgt actgccaaac      840

aatcctccgc tattgcctcc agaatttgta ctagcattat ttccaaacaa acctcctgtg      900

ttattcgtat tcgtagcagg ctttgctcca aacaagcctc cagtgttacc agaggagcta      960

cctccaaaag ccccaacatt gctacctgag gcgtttccaa acataccgcc tgaattggcg     1020

gggttcttgt tggaatttcc aaacatttga ctttaaggtt ttaaagaacg ttgttttgac     1080

aagggaaaca aaagttccca ctaaattttt cgatgtaagg acttgggagg agcaactgct     1140

tacatgaact ccctctaact ttcctcataa aaatccttcc aagctcgcga ggtcccttcc     1200

aactaagtcg ggtaagttt                                                  1219


<210>  2
<211>  1475
<212>  DNA
<213>  Pichia pastoris

<400>  2
tgcccggact tctatccagc aaatttacgg aacggtgttc aatcaagtgt tgagcgctca       60

acctcagttg cagcctgtca gaggcttctc aaatccggta cctgaaaccc ctgtaaatgg      120

agtccaagcg aatgaacaac actctgattc tacccctcaa aatcattcta gggatgaaaa      180

ccaaggaaga ggtcgtggta gaggcagagg aaatagaaga ggaagaggtc gaggtagagg      240

caaaggagga cagtaaatca gaatgaaggt gtccctccga ttgaatagaa ttgtgttgta      300

atattagtgt attgcgttaa tggtactaat aatcatcctg cattgtataa ctaagaactt      360

tcttctcctg ccttagagca gtcgtcttga aaactttttg ctcccagcca ttagacctat      420

caattccgtc ccatctatac cctggcatta tagagaaacg attgtccggg aaagaagatt      480

tgtatagttt acggcctgtc tgtgagatgt aacggtcttt ttgcagcgac ttgactttat      540

ctggagaaaa tgctagcaac gggtcatcta catagcttgg cggagctact cttttagtgg      600

ccgtttgagt aacctcgggg agattcatat tgcgtaattt ttcagatgct tctttggctt      660

tctgtttttc ttgctgtgat ttctgtctct gttgttctag catttcctca tgagagagga      720

cgtttcctga taagtctcta taaatagtgg cattctcggg ttttgcaggt tttgtgggtt      780

tttgtatcga cgacttgggt ttcggcttca gtgatttatc ccttttcttg gacttggatt      840

tgccatattt ggaatccagg tagtcctgta gtgacattcg tttcgatact aggtgcgatg      900

gttcattcga tacgatatat aatgcttaca taagctaatg gtactgggaa catcacttat      960

actatccgtt cagatcaaca ggagaattca ttcatacaac atgccaaatt cattgaagac     1020

ccagtcatca ttccatcaga ctgcccttgg ttaaaggtga taaggaatta attgaggttt     1080

atcggggttt aaagtgaggc gggcatcaag aaaaaaaaaa agagggcagg agcagtggaa     1140

ctttcaaaac aagaaagaga taaatcttat ctcgtgaccc ctatcttagc aaataacgtt     1200

tacgtttgaa ggtaatagat taagcaacca attacctcat cctaacttac gagtaatatc     1260

ccgtttcatc tcatcatcaa tgagggactt gattttatac cgacattgtt ggctccccac     1320

attaaccctt taaagcagga agatccaatt ccccgaggga caaacttgac accctaactt     1380

tcccggggtt cacgaaatat tcatgaaccc ccccccttga tacgaacatc tgcgccgtat     1440

gcacccttct gggacatacc gcctgaggcc acctc                                1475


<210>  3
<211>  3029
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  3
aggcctcgca acaacctata attgagttaa gtgcctttcc aagctaaaaa gtttgaggtt       60

ataggggctt agcatccaca cgtcacaatc tcgggtatcg agtatagtat gtagaattac      120

ggcaggaggt ttcccaatga acaaaggaca ggggcacggt gagctgtcga aggtatccat      180

tttatcatgt ttcgtttgta caagcacgac atactaagac atttaccgta tgggagttgt      240

tgtcctagcg tagttctcgc tcccccagca aagctcaaaa aagtacgtca tttagaatag      300

tttgtgagca aattaccagt cggtatgcta cgttagaaag gcccacagta ttcttctacc      360

aaaggcgtgc ctttgttgaa ctcgatccat tatgagggct tccattattc cccgcatttt      420

tattactctg aacaggaata aaaagaaaaa acccagttta ggaaattatc cgggggcgaa      480

gaaatacgcg tagcgttaat cgaccccacg tccagggttt ttccatggag gtttctggaa      540

aaactgacga ggaatgtgat tataaatccc tttatgtgat gtctaagact tttaaggtac      600

gcccgatgtt tgcctattac catcatagag acgtttcttt tcgaggaatg cttaaacgac      660

tttgtttgac aaaaatgttg cctaagggct ctatagtaaa ccatttggaa gaaagatttg      720

acgacttttt ttttttggat ttcgatccta taatccttcc tcctgaaaag aaacatataa      780

atagatatgt attattcttc aaaacattct cttgttcttg tgcttttttt ttaccatata      840

tcttactttt ttttttctct cagagaaaca agcaaaacaa aaagcttttc ttttcactaa      900

cgtatatgat gcttttgcaa gctttccttt tccttttggc tggttttgca gccaaaatat      960

ctgcatcaat gacaaacgaa actagcgata gacctttggt ccacttcaca cccaacaagg     1020

gctggatgaa tgacccaaat gggttgtggt acgatgaaaa agatgccaaa tggcatctgt     1080

actttcaata caacccaaat gacaccgtat ggggtacgcc attgttttgg ggccatgcta     1140

cttccgatga tttgactaat tgggaagatc aacccattgc tatcgctccc aagcgtaacg     1200

attcaggtgc tttctctggc tccatggtgg ttgattacaa caacacgagt gggtttttca     1260

atgatactat tgatccaaga caaagatgcg ttgcgatttg gacttataac actcctgaaa     1320

gtgaagagca atacattagc tattctcttg atggtggtta cacttttact gaataccaaa     1380

agaaccctgt tttagctgcc aactccactc aattcagaga tccaaaggtg ttctggtatg     1440

aaccttctca aaaatggatt atgacggctg ccaaatcaca agactacaaa attgaaattt     1500

actcctctga tgacttgaag tcctggaagc tagaatctgc atttgccaat gaaggtttct     1560

taggctacca atacgaatgt ccaggtttga ttgaagtccc aactgagcaa gatccttcca     1620

aatcttattg ggtcatgttt atttctatca acccaggtgc acctgctggc ggttccttca     1680

accaatattt tgttggatcc ttcaatggta ctcattttga agcgtttgac aatcaatcta     1740

gagtggtaga ttttggtaag gactactatg ccttgcaaac tttcttcaac actgacccaa     1800

cctacggttc agcattaggt attgcctggg cttcaaactg ggagtacagt gcctttgtcc     1860

caactaaccc atggagatca tccatgtctt tggtccgcaa gttttctttg aacactgaat     1920

atcaagctaa tccagagact gaattgatca atttgaaagc cgaaccaata ttgaacatta     1980

gtaatgctgg tccctggtct cgttttgcta ctaacacaac tctaactaag gccaattctt     2040

acaatgtcga tttgagcaac tcgactggta ccctagagtt tgagttggtt tacgctgtta     2100

acaccacaca aaccatatcc aaatccgtct ttgccgactt atcactttgg ttcaagggtt     2160

tagaagatcc tgaagaatat ttgagaatgg gttttgaagt cagtgcttct tccttctttt     2220

tggaccgtgg taactctaag gtcaagtttg tcaaggagaa cccatatttc acaaacagaa     2280

tgtctgtcaa caaccaacca ttcaagtctg agaacgacct aagttactat aaagtgtacg     2340

gcctactgga tcaaaacatc ttggaattgt acttcaacga tggagatgtg gtttctacaa     2400

atacctactt catgaccacc ggtaacgctc taggatctgt gaacatgacc actggtgtcg     2460

ataatttgtt ctacattgac aagttccaag taagggaagt aaaatagagg ttataaaact     2520

tattgtcttt tttatttttt tcaaaagcca ttctaaaggg ctttagctaa cgagtgacga     2580

atgtaaaact ttatgatttc aaagaatacc tccaaaccat tgaaaatgta tttttatttt     2640

tattttctcc cgaccccagt tacctggaat ttgttcttta tgtactttat ataagtataa     2700

ttctcttaaa aatttttact actttgcaat agacatcatt ttttcacgta ataaacccac     2760

aatcgtaatg tagttgcctt acactactag gatggacctt tttgccttta tctgttttgt     2820

tactgacaca atgaaaccgg gtaaagtatt agttatgtga aaatttaaaa gcattaagta     2880

gaagtatacc atattgtaaa aaaaaaaagc gttgtcttct acgtaaaagt gttctcaaaa     2940

agaagtagtg agggaaatgg ataccaagct atctgtaaca ggagctaaaa aatctcaggg     3000

aaaagcttct ggtttgggaa acggtcgac                                       3029


<210>  4
<211>  898
<212>  DNA
<213>  Pichia pastoris

<400>  4
atcggccttt gttgatgcaa gttttacgtg gatcatggac taaggagttt tatttggacc       60

aagttcatcg tcctagacat tacggaaagg gttctgctcc tctttttgga aactttttgg      120

aacctctgag tatgacagct tggtggattg tacccatggt atggcttcct gtgaatttct      180

attttttcta cattggattc accaatcaaa acaaattagt cgccatggct ttttggcttt      240

tgggtctatt tgtttggacc ttcttggaat atgctttgca tagatttttg ttccacttgg      300

actactatct tccagagaat caaattgcat ttaccattca tttcttattg catgggatac      360

accactattt accaatggat aaatacagat tggtgatgcc acctacactt ttcattgtac      420

tttgctaccc aatcaagacg ctcgtctttt ctgttctacc atattacatg gcttgttctg      480

gatttgcagg tggattcctg ggctatatca tgtatgatgt cactcattac gttctgcatc      540

actccaagct gcctcgttat ttccaagagt tgaagaaata tcatttggaa catcactaca      600

agaattacga gttaggcttt ggtgtcactt ccaaattctg ggacaaagtc tttgggactt      660

atctgggtcc agacgatgtg tatcaaaaga caaattagag tatttataaa gttatgtaag      720

caaatagggg ctaataggga aagaaaaatt ttggttcttt atcagagctg gctcgcgcgc      780

agtgtttttc gtgctccttt gtaatagtca tttttgacta ctgttcagat tgaaatcaca      840

ttgaagatgt cactcgaggg gtaccaaaaa aggtttttgg atgctgcagt ggcttcgc        898


<210>  5
<211>  1060
<212>  DNA
<213>  Pichia pastoris

<400>  5
ggtcttttca acaaagctcc attagtgagt cagctggctg aatcttatgc acaggccatc       60

attaacagca acctggagat agacgttgta tttggaccag cttataaagg tattcctttg      120

gctgctatta ccgtgttgaa gttgtacgag ctcggcggca aaaaatacga aaatgtcgga      180

tatgcgttca atagaaaaga aaagaaagac cacggagaag gtggaagcat cgttggagaa      240

agtctaaaga ataaaagagt actgattatc gatgatgtga tgactgcagg tactgctatc      300

aacgaagcat ttgctataat tggagctgaa ggtgggagag ttgaaggtag tattattgcc      360

ctagatagaa tggagactac aggagatgac tcaaatacca gtgctaccca ggctgttagt      420

cagagatatg gtacccctgt cttgagtata gtgacattgg accatattgt ggcccatttg      480

ggcgaaactt tcacagcaga cgagaaatct caaatggaaa cgtatagaaa aaagtatttg      540

cccaaataag tatgaatctg cttcgaatga atgaattaat ccaattatct tctcaccatt      600

attttcttct gtttcggagc tttgggcacg gcggcgggtg gtgcgggctc aggttccctt      660

tcataaacag atttagtact tggatgctta atagtgaatg gcgaatgcaa aggaacaatt      720

tcgttcatct ttaacccttt cactcggggt acacgttctg gaatgtaccc gccctgttgc      780

aactcaggtg gaccgggcaa ttcttgaact ttctgtaacg ttgttggatg ttcaaccaga      840

aattgtccta ccaactgtat tagtttcctt ttggtcttat attgttcatc gagatacttc      900

ccactctcct tgatagccac tctcactctt cctggattac caaaatcttg aggatgagtc      960

ttttcaggct ccaggatgca aggtatatcc aagtacctgc aagcatctaa tattgtcttt     1020

gccagggggt tctccacacc atactccttt tggcgcatgc                           1060


<210>  6
<211>  957
<212>  DNA
<213>  Pichia pastoris

<400>  6
tctagaggga cttatctggg tccagacgat gtgtatcaaa agacaaatta gagtatttat       60

aaagttatgt aagcaaatag gggctaatag ggaaagaaaa attttggttc tttatcagag      120

ctggctcgcg cgcagtgttt ttcgtgctcc tttgtaatag tcatttttga ctactgttca      180

gattgaaatc acattgaaga tgtcactgga ggggtaccaa aaaaggtttt tggatgctgc      240

agtggcttcg caggccttga agtttggaac tttcaccttg aaaagtggaa gacagtctcc      300

atacttcttt aacatgggtc ttttcaacaa agctccatta gtgagtcagc tggctgaatc      360

ttatgctcag gccatcatta acagcaacct ggagatagac gttgtatttg gaccagctta      420

taaaggtatt cctttggctg ctattaccgt gttgaagttg tacgagctgg gcggcaaaaa      480

atacgaaaat gtcggatatg cgttcaatag aaaagaaaag aaagaccacg gagaaggtgg      540

aagcatcgtt ggagaaagtc taaagaataa aagagtactg attatcgatg atgtgatgac      600

tgcaggtact gctatcaacg aagcatttgc tataattgga gctgaaggtg ggagagttga      660

aggttgtatt attgccctag atagaatgga gactacagga gatgactcaa ataccagtgc      720

tacccaggct gttagtcaga gatatggtac ccctgtcttg agtatagtga cattggacca      780

tattgtggcc catttgggcg aaactttcac agcagacgag aaatctcaaa tggaaacgta      840

tagaaaaaag tatttgccca aataagtatg aatctgcttc gaatgaatga attaatccaa      900

ttatcttctc accattattt tcttctgttt cggagctttg ggcacggcgg cggatcc         957


<210>  7
<211>  709
<212>  DNA
<213>  Escherichia coli

<400>  7
cctgcactgg atggtggcgc tggatggtaa gccgctggca agcggtgaag tgcctctgga       60

tgtcgctcca caaggtaaac agttgattga actgcctgaa ctaccgcagc cggagagcgc      120

cgggcaactc tggctcacag tacgcgtagt gcaaccgaac gcgaccgcat ggtcagaagc      180

cgggcacatc agcgcctggc agcagtggcg tctggcggaa aacctcagtg tgacgctccc      240

cgccgcgtcc cacgccatcc cgcatctgac caccagcgaa atggattttt gcatcgagct      300

gggtaataag cgttggcaat ttaaccgcca gtcaggcttt ctttcacaga tgtggattgg      360

cgataaaaaa caactgctga cgccgctgcg cgatcagttc acccgtgcac cgctggataa      420

cgacattggc gtaagtgaag cgacccgcat tgaccctaac gcctgggtcg aacgctggaa      480

ggcggcgggc cattaccagg ccgaagcagc gttgttgcag tgcacggcag atacacttgc      540

tgatgcggtg ctgattacga ccgctcacgc gtggcagcat caggggaaaa ccttatttat      600

cagccggaaa acctaccgga ttgatggtag tggtcaaatg gcgattaccg ttgatgttga      660

agtggcgagc gatacaccgc atccggcgcg gattggcctg aactgccag                  709


<210>  8
<211>  2875
<212>  DNA
<213>  Pichia pastoris

<400>  8
aaaacctttt ttcctattca aacacaaggc attgcttcaa cacgtgtgcg tatccttaac       60

acagatactc catacttcta ataatgtgat agacgaatac aaagatgttc actctgtgtt      120

gtgtctacaa gcatttctta ttctgattgg ggatattcta gttacagcac taaacaactg      180

gcgatacaaa cttaaattaa ataatccgaa tctagaaaat gaacttttgg atggtccgcc      240

tgttggttgg ataaatcaat accgattaaa tggattctat tccaatgaga gagtaatcca      300

agacactctg atgtcaataa tcatttgctt gcaacaacaa acccgtcatc taatcaaagg      360

gtttgatgag gcttaccttc aattgcagat aaactcattg ctgtccactg ctgtattatg      420

tgagaatatg ggtgatgaat ctggtcttct ccactcagct aacatggctg tttgggcaaa      480

ggtggtacaa ttatacggag atcaggcaat agtgaaattg ttgaatatgg ctactggacg      540

atgcttcaag gatgtacgtc tagtaggagc cgtgggaaga ttgctggcag aaccagttgg      600

cacgtcgcaa caatccccaa gaaatgaaat aagtgaaaac gtaacgtcaa agacagcaat      660

ggagtcaata ttgataacac cactggcaga gcggttcgta cgtcgttttg gagccgatat      720

gaggctcagc gtgctaacag cacgattgac aagaagactc tcgagtgaca gtaggttgag      780

taaagtattc gcttagattc ccaaccttcg ttttattctt tcgtagacaa agaagctgca      840

tgcgaacata gggacaactt ttataaatcc aattgtcaaa ccaacgtaaa accctctggc      900

accattttca acatatattt gtgaagcagt acgcaatatc gataaatact caccgttgtt      960

tgtaacagcc ccaacttgca tacgccttct aatgacctca aatggataag ccgcagcttg     1020

tgctaacata ccagcagcac cgcccgcggt cagctgcgcc cacacatata aaggcaatct     1080

acgatcatgg gaggaattag ttttgaccgt caggtcttca agagttttga actcttcttc     1140

ttgaactgtg taacctttta aatgacggga tctaaatacg tcatggatga gatcatgtgt     1200

gtaaaaactg actccagcat atggaatcat tccaaagatt gtaggagcga acccacgata     1260

aaagtttccc aaccttgcca aagtgtctaa tgctgtgact tgaaatctgg gttcctcgtt     1320

gaagaccctg cgtactatgc ccaaaaactt tcctccacga gccctattaa cttctctatg     1380

agtttcaaat gccaaacgga cacggattag gtccaatggg taagtgaaaa acacagagca     1440

aaccccagct aatgagccgg ccagtaaccg tcttggagct gtttcataag agtcattagg     1500

gatcaataac gttctaatct gttcataaca tacaaatttt atggctgcat agggaaaaat     1560

tctcaacagg gtagccgaat gaccctgata tagacctgcg acaccatcat acccatagat     1620

ctgcctgaca gccttaaaga gcccgctaaa agacccggaa aaccgagaga actctggatt     1680

agcagtctga aaaagaatct tcactctgtc tagtggagca attaatgtct tagcggcact     1740

tcctgctact ccgccagcta ctcctgaata gatcacatac tgcaaagact gcttgtcgat     1800

gaccttgggg ttatttagct tcaagggcaa tttttgggac attttggaca caggagactc     1860

agaaacagac acagagcgtt ctgagtcctg gtgctcctga cgtaggccta gaacaggaat     1920

tattggcttt atttgtttgt ccatttcata ggcttggggt aatagataga tgacagagaa     1980

atagagaaga cctaatattt tttgttcatg gcaaatcgcg ggttcgcggt cgggtcacac     2040

acggagaagt aatgagaaga gctggtaatc tggggtaaaa gggttcaaaa gaaggtcgcc     2100

tggtagggat gcaatacaag gttgtcttgg agtttacatt gaccagatga tttggctttt     2160

tctctgttca attcacattt ttcagcgaga atcggattga cggagaaatg gcggggtgtg     2220

gggtggatag atggcagaaa tgctcgcaat caccgcgaaa gaaagacttt atggaataga     2280

actactgggt ggtgtaagga ttacatagct agtccaatgg agtccgttgg aaaggtaaga     2340

agaagctaaa accggctaag taactaggga agaatgatca gactttgatt tgatgaggtc     2400

tgaaaatact ctgctgcttt ttcagttgct ttttccctgc aacctatcat tttccttttc     2460

ataagcctgc cttttctgtt ttcacttata tgagttccgc cgagacttcc ccaaattctc     2520

tcctggaaca ttctctatcg ctctccttcc aagttgcgcc ccctggcact gcctagtaat     2580

attaccacgc gacttatatt cagttccaca atttccagtg ttcgtagcaa atatcatcag     2640

ccatggcgaa ggcagatggc agtttgctct actataatcc tcacaatcca cccagaaggt     2700

attacttcta catggctata ttcgccgttt ctgtcatttg cgttttgtac ggaccctcac     2760

aacaattatc atctccaaaa atagactatg atccattgac gctccgatca cttgatttga     2820

agactttgga agctccttca cagttgagtc caggcaccgt agaagataat cttcg          2875


<210>  9
<211>  997
<212>  DNA
<213>  Pichia pastoris

<400>  9
aaagctagag taaaatagat atagcgagat tagagaatga ataccttctt ctaagcgatc       60

gtccgtcatc atagaatatc atggactgta tagttttttt tttgtacata taatgattaa      120

acggtcatcc aacatctcgt tgacagatct ctcagtacgc gaaatccctg actatcaaag      180

caagaaccga tgaagaaaaa aacaacagta acccaaacac cacaacaaac actttatctt      240

ctccccccca acaccaatca tcaaagagat gtcggaacca aacaccaaga agcaaaaact      300

aaccccatat aaaaacatcc tggtagataa tgctggtaac ccgctctcct tccatattct      360

gggctacttc acgaagtctg accggtctca gttgatcaac atgatcctcg aaatgggtgg      420

caagatcgtt ccagacctgc ctcctctggt agatggagtg ttgtttttga caggggatta      480

caagtctatt gatgaagata ccctaaagca actgggggac gttccaatat acagagactc      540

cttcatctac cagtgttttg tgcacaagac atctcttccc attgacactt tccgaattga      600

caagaacgtc gacttggctc aagatttgat caatagggcc cttcaagagt ctgtggatca      660

tgtcacttct gccagcacag ctgcagctgc tgctgttgtt gtcgctacca acggcctgtc      720

ttctaaacca gacgctcgta ctagcaaaat acagttcact cccgaagaag atcgttttat      780

tcttgacttt gttaggagaa atcctaaacg aagaaacaca catcaactgt acactgagct      840

cgctcagcac atgaaaaacc atacgaatca ttctatccgc cacagatttc gtcgtaatct      900

ttccgctcaa cttgattggg tttatgatat cgatccattg accaaccaac ctcgaaaaga      960

tgaaaacggg aactacatca aggtacaagg ccttcca                               997


<210>  10
<211>  2159
<212>  DNA
<213>  Kluyveromyces lactis

<400>  10
aaacgtaacg cctggcactc tattttctca aacttctggg acggaagagc taaatattgt       60

gttgcttgaa caaacccaaa aaaacaaaaa aatgaacaaa ctaaaactac acctaaataa      120

accgtgtgta aaacgtagta ccatattact agaaaagatc acaagtgtat cacacatgtg      180

catctcatat tacatctttt atccaatcca ttctctctat cccgtctgtt cctgtcagat      240

tctttttcca taaaaagaag aagaccccga atctcaccgg tacaatgcaa aactgctgaa      300

aaaaaaagaa agttcactgg atacgggaac agtgccagta ggcttcacca catggacaaa      360

acaattgacg ataaaataag caggtgagct tctttttcaa gtcacgatcc ctttatgtct      420

cagaaacaat atatacaagc taaacccttt tgaaccagtt ctctcttcat agttatgttc      480

acataaattg cgggaacaag actccgctgg ctgtcaggta cacgttgtaa cgttttcgtc      540

cgcccaatta ttagcacaac attggcaaaa agaaaaactg ctcgttttct ctacaggtaa      600

attacaattt ttttcagtaa ttttcgctga aaaatttaaa gggcaggaaa aaaagacgat      660

ctcgactttg catagatgca agaactgtgg tcaaaacttg aaatagtaat tttgctgtgc      720

gtgaactaat aaatatatat atatatatat atatatattt gtgtattttg tatatgtaat      780

tgtgcacgtc ttggctattg gatataagat tttcgcgggt tgatgacata gagcgtgtac      840

tactgtaata gttgtatatt caaaagctgc tgcgtggaga aagactaaaa tagataaaaa      900

gcacacattt tgacttcggt accgtcaact tagtgggaca gtcttttata tttggtgtaa      960

gctcatttct ggtactattc gaaacagaac agtgttttct gtattaccgt ccaatcgttt     1020

gtcatgagtt ttgtattgat tttgtcgtta gtgttcggag gatgttgttc caatgtgatt     1080

agtttcgagc acatggtgca aggcagcaat ataaatttgg gaaatattgt tacattcact     1140

caattcgtgt ctgtgacgct aattcagttg cccaatgctt tggacttctc tcactttccg     1200

tttaggttgc gacctagaca cattcctctt aagatccata tgttagctgt gtttttgttc     1260

tttaccagtt cagtcgccaa taacagtgtg tttaaatttg acatttccgt tccgattcat     1320

attatcatta gattttcagg taccactttg acgatgataa taggttgggc tgtttgtaat     1380

aagaggtact ccaaacttca ggtgcaatct gccatcatta tgacgcttgg tgcgattgtc     1440

gcatcattat accgtgacaa agaattttca atggacagtt taaagttgaa tacggattca     1500

gtgggtatga cccaaaaatc tatgtttggt atctttgttg tgctagtggc cactgccttg     1560

atgtcattgt tgtcgttgct caacgaatgg acgtataaca agtacgggaa acattggaaa     1620

gaaactttgt tctattcgca tttcttggct ctaccgttgt ttatgttggg gtacacaagg     1680

ctcagagacg aattcagaga cctcttaatt tcctcagact caatggatat tcctattgtt     1740

aaattaccaa ttgctacgaa acttttcatg ctaatagcaa ataacgtgac ccagttcatt     1800

tgtatcaaag gtgttaacat gctagctagt aacacggatg ctttgacact ttctgtcgtg     1860

cttctagtgc gtaaatttgt tagtctttta ctcagtgtct acatctacaa gaacgtccta     1920

tccgtgactg catacctagg gaccatcacc gtgttcctgg gagctggttt gtattcatat     1980

ggttcggtca aaactgcact gcctcgctga aacaatccac gtctgtatga tactcgtttc     2040

agaatttttt tgattttctg ccggatatgg tttctcatct ttacaatcgc attcttaatt     2100

ataccagaac gtaattcaat gatcccagtg actcgtaact cttatatgtc aatttaagc      2159


<210>  11
<211>  870
<212>  DNA
<213>  Pichia pastoris

<400>  11
ggccgagcgg gcctagattt tcactacaaa tttcaaaact acgcggattt attgtctcag       60

agagcaattt ggcatttctg agcgtagcag gaggcttcat aagattgtat aggaccgtac      120

caacaaattg ccgaggcaca acacggtatg ctgtgcactt atgtggctac ttccctacaa      180

cggaatgaaa ccttcctctt tccgcttaaa cgagaaagtg tgtcgcaatt gaatgcaggt      240

gcctgtgcgc cttggtgtat tgtttttgag ggcccaattt atcaggcgcc ttttttcttg      300

gttgttttcc cttagcctca agcaaggttg gtctatttca tctccgcttc tataccgtgc      360

ctgatactgt tggatgagaa cacgactcaa cttcctgctg ctctgtattg ccagtgtttt      420

gtctgtgatt tggatcggag tcctccttac ttggaatgat aataatcttg gcggaatctc      480

cctaaacgga ggcaaggatt ctgcctatga tgatctgcta tcattgggaa gcttcaacga      540

catggaggtc gactcctatg tcaccaacat ctacgacaat gctccagtgc taggatgtac      600

ggatttgtct tatcatggat tgttgaaagt caccccaaag catgacttag cttgcgattt      660

ggagttcata agagctcaga ttttggacat tgacgtttac tccgccataa aagacttaga      720

agataaagcc ttgactgtaa aacaaaaggt tgaaaaacac tggtttacgt tttatggtag      780

ttcagtcttt ctgcccgaac acgatgtgca ttacctggtt agacgagtca tcttttcggc      840

tgaaggaaag gcgaactctc cagtaacatc                                       870


<210>  12
<211>  1733
<212>  DNA
<213>  Pichia pastoris

<400>  12
ccatatgatg ggtgtttgct cactcgtatg gatcaaaatt ccatggtttc ttctgtacaa       60

cttgtacact tatttggact tttctaacgg tttttctggt gatttgagaa gtccttattt      120

tggtgttcgc agcttatccg tgattgaacc atcagaaata ctgcagctcg ttatctagtt      180

tcagaatgtg ttgtagaata caatcaattc tgagtctagt ttgggtgggt cttggcgacg      240

ggaccgttat atgcatctat gcagtgttaa ggtacataga atgaaaatgt aggggttaat      300

cgaaagcatc gttaatttca gtagaacgta gttctattcc ctacccaaat aatttgccaa      360

gaatgcttcg tatccacata cgcagtggac gtagcaaatt tcactttgga ctgtgacctc      420

aagtcgttat cttctacttg gacattgatg gtcattacgt aatccacaaa gaattggata      480

gcctctcgtt ttatctagtg cacagcctaa tagcacttaa gtaagagcaa tggacaaatt      540

tgcatagaca ttgagctaga tacgtaactc agatcttgtt cactcatggt gtactcgaag      600

tactgctgga accgttacct cttatcattt cgctactggc tcgtgaaact actggatgaa      660

aaaaaaaaaa gagctgaaag cgagatcatc ccattttgtc atcatacaaa ttcacgcttg      720

cagttttgct tcgttaacaa gacaagatgt ctttatcaaa gacccgtttt ttcttcttga      780

agaatacttc cctgttgagc acatgcaaac catatttatc tcagatttca ctcaacttgg      840

gtgcttccaa gagaagtaaa attcttccca ctgcatcaac ttccaagaaa cccgtagacc      900

agtttctctt cagccaaaag aagttgctcg ccgatcaccg cggtaacaga ggagtcagaa      960

ggtttcacac ccttccatcc cgatttcaaa gtcaaagtgc tgcgttgaac caaggttttc     1020

aggttgccaa agcccagtct gcaaaaacta gttccaaatg gcctattaat tcccataaaa     1080

gtgttggcta cgtatgtatc ggtacctcca ttctggtatt tgctattgtt gtcgttggtg     1140

ggttgactag actgaccgaa tccggtcttt ccataacgga gtggaaacct atcactggtt     1200

cggttccccc actgactgag gaagactgga agttggaatt tgaaaaatac aaacaaagcc     1260

ctgagtttca ggaactaaat tctcacataa cattggaaga gttcaagttt atattttcca     1320

tggaatgggg acatagattg ttgggaaggg tcatcggcct gtcgtttgtt cttcccacgt     1380

tttacttcat tgcccgtcga aagtgttcca aagatgttgc attgaaactg cttgcaatat     1440

gctctatgat aggattccaa ggtttcatcg gctggtggat ggtgtattcc ggattggaca     1500

aacagcaatt ggctgaacgt aactccaaac caactgtgtc tccatatcgc ttaactaccc     1560

atcttggaac tgcatttgtt atttactgtt acatgattta cacagggctt caagttttga     1620

agaactataa gatcatgaaa cagcctgaag cgtatgttca aattttcaag caaattgcgt     1680

ctccaaaatt gaaaactttc aagagactct cttcagttct attaggcctg gtg            1733


<210>  13
<211>  981
<212>  DNA
<213>  Mus musculus

<400>  13
atgtctgcca acctaaaata tctttccttg ggaattttgg tgtttcagac taccagtctg       60

gttctaacga tgcggtattc taggacttta aaagaggagg ggcctcgtta tctgtcttct      120

acagcagtgg ttgtggctga atttttgaag ataatggcct gcatcttttt agtctacaaa      180

gacagtaagt gtagtgtgag agcactgaat agagtactgc atgatgaaat tcttaataag      240

cccatggaaa ccctgaagct cgctatcccg tcagggatat atactcttca gaacaactta      300

ctctatgtgg cactgtcaaa cctagatgca gccacttacc aggttacata tcagttgaaa      360

atacttacaa cagcattatt ttctgtgtct atgcttggta aaaaattagg tgtgtaccag      420

tggctctccc tagtaattct gatggcagga gttgcttttg tacagtggcc ttcagattct      480

caagagctga actctaagga cctttcaaca ggctcacagt ttgtaggcct catggcagtt      540

ctcacagcct gtttttcaag tggctttgct ggagtttatt ttgagaaaat cttaaaagaa      600

acaaaacagt cagtatggat aaggaacatt caacttggtt tctttggaag tatatttgga      660

ttaatgggtg tatacgttta tgatggagaa ttggtctcaa agaatggatt ttttcaggga      720

tataatcaac tgacgtggat agttgttgct ctgcaggcac ttggaggcct tgtaatagct      780

gctgtcatca aatatgcaga taacatttta aaaggatttg cgacctcctt atccataata      840

ttgtcaacaa taatatctta tttttggttg caagattttg tgccaaccag tgtctttttc      900

cttggagcca tccttgtaat agcagctact ttcttgtatg gttacgatcc caaacctgca      960

ggaaatccca ctaaagcata g                                                981


<210>  14
<211>  486
<212>  DNA
<213>  Pichia pastoris

<400>  14
tttttgtaga aatgtcttgg tgtcctcgtc caatcaggta gccatctctg aaatatctgg       60

ctccgttgca actccgaacg acctgctggc aacgtaaaat tctccggggt aaaacttaaa      120

tgtggagtaa tggaaccaga aacgtctctt cccttctctc tccttccacc gcccgttacc      180

gtccctagga aattttactc tgctggagag cttcttctac ggcccccttg cagcaatgct      240

cttcccagca ttacgttgcg ggtaaaacgg aggtcgtgta cccgacctag cagcccaggg      300

atggaaaagt cccggccgtc gctggcaata atagcgggcg gacgcatgtc atgagattat      360

tggaaaccac cagaatcgaa tataaaaggc gaacaccttt cccaattttg gtttctcctg      420

acccaaagac tttaaattta atttatttgt ccctatttca atcaattgaa caactatcaa      480

aacaca                                                                 486


<210>  15
<211>  293
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  15
acaggcccct tttcctttgt cgatatcatg taattagtta tgtcacgctt acattcacgc       60

cctcctccca catccgctct aaccgaaaag gaaggagtta gacaacctga agtctaggtc      120

cctatttatt ttttttaata gttatgttag tattaagaac gttatttata tttcaaattt      180

ttcttttttt tctgtacaaa cgcgtgtacg catgtaacat tatactgaaa accttgcttg      240

agaaggtttt gggacgctcg aaggctttaa tttgcaagct gccggctctt aag             293


<210>  16
<211>  1128
<212>  DNA
<213>  Pichia pastoris

<400>  16
gatctggcca ttgtgaaact tgacactaaa gacaaaactc ttagagtttc caatcactta       60

ggagacgatg tttcctacaa cgagtacgat ccctcattga tcatgagcaa tttgtatgtg      120

aaaaaagtca tcgaccttga caccttggat aaaagggctg gaggaggtgg aaccacctgt      180

gcaggcggtc tgaaagtgtt caagtacgga tctactacca aatatacatc tggtaacctg      240

aacggcgtca ggttagtata ctggaacgaa ggaaagttgc aaagctccaa atttgtggtt      300

cgatcctcta attactctca aaagcttgga ggaaacagca acgccgaatc aattgacaac      360

aatggtgtgg gttttgcctc agctggagac tcaggcgcat ggattctttc caagctacaa      420

gatgttaggg agtaccagtc attcactgaa aagctaggtg aagctacgat gagcattttc      480

gatttccacg gtcttaaaca ggagacttct actacagggc ttggggtagt tggtatgatt      540

cattcttacg acggtgagtt caaacagttt ggtttgttca ctccaatgac atctattcta      600

caaagacttc aacgagtgac caatgtagaa tggtgtgtag cgggttgcga agatggggat      660

gtggacactg aaggagaaca cgaattgagt gatttggaac aactgcatat gcatagtgat      720

tccgactagt caggcaagag agagccctca aatttacctc tctgcccctc ctcactcctt      780

ttggtacgca taattgcagt ataaagaact tgctgccagc cagtaatctt atttcatacg      840

cagttctata tagcacataa tcttgcttgt atgtatgaaa tttaccgcgt tttagttgaa      900

attgtttatg ttgtgtgcct tgcatgaaat ctctcgttag ccctatcctt acatttaact      960

ggtctcaaaa cctctaccaa ttccattgct gtacaacaat atgaggcggc attactgtag     1020

ggttggaaaa aaattgtcat tccagctaga gatcacacga cttcatcacg cttattgctc     1080

ctcattgcta aatcatttac tcttgacttc gacccagaaa agttcgcc                  1128


<210>  17
<211>  1231
<212>  DNA
<213>  Pichia pastoris

<400>  17
gcatgtcaaa cttgaacaca acgactagat agttgttttt tctatataaa acgaaacgtt       60

atcatcttta ataatcattg aggtttaccc ttatagttcc gtattttcgt ttccaaactt      120

agtaatcttt tggaaatatc atcaaagctg gtgccaatct tcttgtttga agtttcaaac      180

tgctccacca agctacttag agactgttct aggtctgaag caacttcgaa cacagagaca      240

gctgccgccg attgttcttt tttgtgtttt tcttctggaa gaggggcatc atcttgtatg      300

tccaatgccc gtatcctttc tgagttgtcc gacacattgt ccttcgaaga gtttcctgac      360

attgggcttc ttctatccgt gtattaattt tgggttaagt tcctcgtttg catagcagtg      420

gatacctcga tttttttggc tcctatttac ctgacataat attctactat aatccaactt      480

ggacgcgtca tctatgataa ctaggctctc ctttgttcaa aggggacgtc ttcataatcc      540

actggcacga agtaagtctg caacgaggcg gcttttgcaa cagaacgata gtgtcgtttc      600

gtacttggac tatgctaaac aaaaggatct gtcaaacatt tcaaccgtgt ttcaaggcac      660

tctttacgaa ttatcgacca agaccttcct agacgaacat ttcaacatat ccaggctact      720

gcttcaaggt ggtgcaaatg ataaaggtat agatattaga tgtgtttggg acctaaaaca      780

gttcttgcct gaagattccc ttgagcaaca ggcttcaata gccaagttag agaagcagta      840

ccaaatcggt aacaaaaggg ggaagcatat aaaaccttta ctattgcgac aaaatccatc      900

cttgaaagta aagctgtttg ttcaatgtaa agcatacgaa acgaaggagg tagatcctaa      960

gatggttaga gaacttaacg ggacatactc cagctgcatc ccatattacg atcgctggaa     1020

gacttttttc atgtacgtat cgcccaccaa cctttcaaag caagctaggt atgattttga     1080

cagttctcac aatccattgg ttttcatgca acttgaaaaa acccaactca aacttcatgg     1140

ggatccatac aatgtaaatc attacgagag ggcgaggttg aaaagtttcc attgcaatca     1200

cgtcgcatca tggctactga aaggccttaa c                                    1231


<210>  18
<211>  937
<212>  DNA
<213>  Pichia pastoris

<400>  18
tcattctata tgttcaagaa aagggtagtg aaaggaaaga aaaggcatat aggcgaggga       60

gagttagcta gcatacaaga taatgaagga tcaatagcgg tagttaaagt gcacaagaaa      120

agagcacctg ttgaggctga tgataaagct ccaattacat tgccacagag aaacacagta      180

acagaaatag gaggggatgc accacgagaa gagcattcag tgaacaactt tgccaaattc      240

ataaccccaa gcgctaataa gccaatgtca aagtcggcta ctaacattaa tagtacaaca      300

actatcgatt ttcaaccaga tgtttgcaag gactacaaac agacaggtta ctgcggatat      360

ggtgacactt gtaagttttt gcacctgagg gatgatttca aacagggatg gaaattagat      420

agggagtggg aaaatgtcca aaagaagaag cataatactc tcaaaggggt taaggagatc      480

caaatgttta atgaagatga gctcaaagat atcccgttta aatgcattat atgcaaagga      540

gattacaaat cacccgtgaa aacttcttgc aatcattatt tttgcgaaca atgtttcctg      600

caacggtcaa gaagaaaacc aaattgtatt atatgtggca gagacacttt aggagttgct      660

ttaccagcaa agaagttgtc ccaatttctg gctaagatac ataataatga aagtaataaa      720

gtttagtaat tgcattgcgt tgactattga ttgcattgat gtcgtgtgat actttcaccg      780

aaaaaaaaca cgaagcgcaa taggagcggt tgcatattag tccccaaagc tatttaattg      840

tgcctgaaac tgttttttaa gctcatcaag cataattgta tgcattgcga cgtaaccaac      900

gtttaggcgc agtttaatca tagcccactg ctaagcc                               937


<210>  19
<211>  1906
<212>  DNA
<213>  Pichia pastoris

<400>  19
cggaggaatg caaataataa tctccttaat tacccactga taagctcaag agacgcggtt       60

tgaaaacgat ataatgaatc atttggattt tataataaac cctgacagtt tttccactgt      120

attgttttaa cactcattgg aagctgtatt gattctaaga agctagaaat caatacggcc      180

atacaaaaga tgacattgaa taagcaccgg cttttttgat tagcatatac cttaaagcat      240

gcattcatgg ctacatagtt gttaaagggc ttcttccatt atcagtataa tgaattacat      300

aatcatgcac ttatatttgc ccatctctgt tctctcactc ttgcctgggt atattctatg      360

aaattgcgta tagcgtgtct ccagttgaac cccaagcttg gcgagtttga agagaatgct      420

aaccttgcgt attccttgct tcaggaaaca ttcaaggaga aacaggtcaa gaagccaaac      480

attttgatcc ttcccgagtt agcattgact ggctacaatt ttcaaagcca gcagcggata      540

gagccttttt tggaggaaac aaccaaggga gctagtaccc aatgggctca aaaagtatcc      600

aagacgtggg attgctttac tttaatagga tacccagaaa aaagtttaga gagccctccc      660

cgtatttaca acagtgcggt acttgtatcg cctcagggaa aagtaatgaa caactacaga      720

aagtccttct tgtatgaagc tgatgaacat tggggatgtt cggaatcttc tgatgggttt      780

caaacagtag atttattaat tgaaggaaag actgtaaaga catcatttgg aatttgcatg      840

gatttgaatc cttataaatt tgaagctcca ttcacagact tcgagttcag tggccattgc      900

ttgaaaaccg gtacaagact cattttgtgc ccaatggcct ggttgtcccc tctatcgcct      960

tccattaaaa aggatcttag tgatatagag aaaagcagac ttcaaaagtt ctaccttgaa     1020

aaaatagata ccccggaatt tgacgttaat tacgaattga aaaaagatga agtattgccc     1080

acccgtatga atgaaacgtt ggaaacaatt gactttgagc cttcaaaacc ggactactct     1140

aatataaatt attggatact aaggtttttt ccctttctga ctcatgtcta taaacgagat     1200

gtgctcaaag agaatgcagt tgcagtctta tgcaaccgag ttggcattga gagtgatgtc     1260

ttgtacggag gatcaaccac gattctaaac ttcaatggta agttagcatc gacacaagag     1320

gagctggagt tgtacgggca gactaatagt ctcaacccca gtgtggaagt attgggggcc     1380

cttggcatgg gtcaacaggg aattctagta cgagacattg aattaacata atatacaata     1440

tacaataaac acaaataaag aatacaagcc tgacaaaaat tcacaaatta ttgcctagac     1500

ttgtcgttat cagcagcgac ctttttccaa tgctcaattt cacgatatgc cttttctagc     1560

tctgctttaa gcttctcatt ggaattggct aactcgttga ctgcttggtc agtgatgagt     1620

ttctccaagg tccatttctc gatgttgttg ttttcgtttt cctttaatct cttgatataa     1680

tcaacagcct tctttaatat ctgagccttg ttcgagtccc ctgttggcaa cagagcggcc     1740

agttccttta ttccgtggtt tatattttct cttctacgcc tttctacttc tttgtgattc     1800

tctttacgca tcttatgcca ttcttcagaa ccagtggctg gcttaaccga atagccagag     1860

cctgaagaag ccgcactaga agaagcagtg gcattgttga ctatgg                    1906


<210>  20
<211>  1224
<212>  DNA
<213>  Homo sapiens

<400>  20
tcagtcagtg ctcttgatgg tgacccagca agtttgacca gagaagtgat tagattggcc       60

caagacgcag aggtggagtt ggagagacaa cgtggactgc tgcagcaaat cggagatgca      120

ttgtctagtc aaagaggtag ggtgcctacc gcagctcctc cagcacagcc tagagtgcat      180

gtgacccctg caccagctgt gattcctatc ttggtcatcg cctgtgacag atctactgtt      240

agaagatgtc tggacaagct gttgcattac agaccatctg ctgagttgtt ccctatcatc      300

gttagtcaag actgtggtca cgaggagact gcccaagcca tcgcctccta cggatctgct      360

gtcactcaca tcagacagcc tgacctgtca tctattgctg tgccaccaga ccacagaaag      420

ttccaaggtt actacaagat cgctagacac tacagatggg cattgggtca agtcttcaga      480

cagtttagat tccctgctgc tgtggtggtg gaggatgact tggaggtggc tcctgacttc      540

tttgagtact ttagagcaac ctatccattg ctgaaggcag acccatccct gtggtgtgtc      600

tctgcctgga atgacaacgg taaggagcaa atggtggacg cttctaggcc tgagctgttg      660

tacagaaccg acttctttcc tggtctggga tggttgctgt tggctgagtt gtgggctgag      720

ttggagccta agtggccaaa ggcattctgg gacgactgga tgagaagacc tgagcaaaga      780

cagggtagag cctgtatcag acctgagatc tcaagaacca tgacctttgg tagaaaggga      840

gtgtctcacg gtcaattctt tgaccaacac ttgaagttta tcaagctgaa ccagcaattt      900

gtgcacttca cccaactgga cctgtcttac ttgcagagag aggcctatga cagagatttc      960

ctagctagag tctacggagc tcctcaactg caagtggaga aagtgaggac caatgacaga     1020

aaggagttgg gagaggtgag agtgcagtac actggtaggg actcctttaa ggctttcgct     1080

aaggctctgg gtgtcatgga tgaccttaag tctggagttc ctagagctgg ttacagaggt     1140

attgtcacct ttcaattcag aggtagaaga gtccacttgg ctcctccacc tacttgggag     1200

ggttatgatc cttcttggaa ttag                                            1224


<210>  21
<211>  99
<212>  DNA
<213>  Pichia pastoris

<400>  21
atgcccagaa aaatatttaa ctacttcatt ttgactgtat tcatggcaat tcttgctatt       60

gttttacaat ggtctataga gaatggacat gggcgcgcc                              99


<210>  22
<211>  435
<212>  DNA
<213>  Pichia pastoris

<400>  22
gaagtaaagt tggcgaaact ttgggaacct ttggttaaaa ctttgtaatt tttgtcgcta       60

cccattaggc agaatctgca tcttgggagg gggatgtggt ggcgttctga gatgtacgcg      120

aagaatgaag agccagtggt aacaacaggc ctagagagat acgggcataa tgggtataac      180

ctacaagtta agaatgtagc agccctggaa accagattga aacgaaaaac gaaatcattt      240

aaactgtagg atgttttggc tcattgtctg gaaggctggc tgtttattgc cctgttcttt      300

gcatgggaat aagctattat atccctcaca taatcccaga aaatagattg aagcaacgcg      360

aaatccttac gtatcgaagt agccttctta cacattcacg ttgtacggat aagaaaacta      420

ctcaaacgaa caatc                                                       435


<210>  23
<211>  404
<212>  DNA
<213>  Pichia pastoris

<400>  23
aatagatata gcgagattag agaatgaata ccttcttcta agcgatcgtc cgtcatcata       60

gaatatcatg gactgtatag tttttttttt gtacatataa tgattaaacg gtcatccaac      120

atctcgttga cagatctctc agtacgcgaa atccctgact atcaaagcaa gaaccgatga      180

agaaaaaaac aacagtaacc caaacaccac aacaaacact ttatcttctc ccccccaaca      240

ccaatcatca aagagatgtc ggaacacaaa caccaagaag caaaaactaa ccccatataa      300

aaacatcctg gtagataatg ctggtaaccc gctctccttc catattctgg gctacttcac      360

gaagtctgac cggtctcagt tgatcaacat gatcctcgaa atgg                       404


<210>  24
<211>  1407
<212>  DNA
<213>  Mus musculus

<400>  24
gagcccgctg acgccaccat ccgtgagaag agggcaaaga tcaaagagat gatgacccat       60

gcttggaata attataaacg ctatgcgtgg ggcttgaacg aactgaaacc tatatcaaaa      120

gaaggccatt caagcagttt gtttggcaac atcaaaggag ctacaatagt agatgccctg      180

gatacccttt tcattatggg catgaagact gaatttcaag aagctaaatc gtggattaaa      240

aaatatttag attttaatgt gaatgctgaa gtttctgttt ttgaagtcaa catacgcttc      300

gtcggtggac tgctgtcagc ctactatttg tccggagagg agatatttcg aaagaaagca      360

gtggaacttg gggtaaaatt gctacctgca tttcatactc cctctggaat accttgggca      420

ttgctgaata tgaaaagtgg gatcgggcgg aactggccct gggcctctgg aggcagcagt      480

atcctggccg aatttggaac tctgcattta gagtttatgc acttgtccca cttatcagga      540

gacccagtct ttgccgaaaa ggttatgaaa attcgaacag tgttgaacaa actggacaaa      600

ccagaaggcc tttatcctaa ctatctgaac cccagtagtg gacagtgggg tcaacatcat      660

gtgtcggttg gaggacttgg agacagcttt tatgaatatt tgcttaaggc gtggttaatg      720

tctgacaaga cagatctcga agccaagaag atgtattttg atgctgttca ggccatcgag      780

actcacttga tccgcaagtc aagtggggga ctaacgtaca tcgcagagtg gaaggggggc      840

ctcctggaac acaagatggg ccacctgacg tgctttgcag gaggcatgtt tgcacttggg      900

gcagatggag ctccggaagc ccgggcccaa cactaccttg aactcggagc tgaaattgcc      960

cgcacttgtc atgaatctta taatcgtaca tatgtgaagt tgggaccgga agcgtttcga     1020

tttgatggcg gtgtggaagc tattgccacg aggcaaaatg aaaagtatta catcttacgg     1080

cccgaggtca tcgagacata catgtacatg tggcgactga ctcacgaccc caagtacagg     1140

acctgggcct gggaagccgt ggaggctcta gaaagtcact gcagagtgaa cggaggctac     1200

tcaggcttac gggatgttta cattgcccgt gagagttatg acgatgtcca gcaaagtttc     1260

ttcctggcag agacactgaa gtatttgtac ttgatatttt ccgatgatga ccttcttcca     1320

ctagaacact ggatcttcaa caccgaggct catcctttcc ctatactccg tgaacagaag     1380

aaggaaattg atggcaaaga gaaatga                                         1407


<210>  25
<211>  318
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  25
atgaacacta tccacataat aaaattaccg cttaactacg ccaactacac ctcaatgaaa       60

caaaaaatct ctaaattttt caccaacttc atccttattg tgctgctttc ttacatttta      120

cagttctcct ataagcacaa tttgcattcc atgcttttca attacgcgaa ggacaatttt      180

ctaacgaaaa gagacaccat ctcttcgccc tacgtagttg atgaagactt acatcaaaca      240

actttgtttg gcaaccacgg tacaaaaaca tctgtaccta gcgtagattc cataaaagtg      300

catggcgtgg ggcgcgcc                                                    318


<210>  26
<211>  1250
<212>  DNA
<213>  Pichia pastoris

<400>  26
gagtcggcca agagatgata actgttacta agcttctccg taattagtgg tattttgtaa       60

cttttaccaa taatcgttta tgaatacgga tatttttcga ccttatccag tgccaaatca      120

cgtaacttaa tcatggttta aatactccac ttgaacgatt cattattcag aaaaaagtca      180

ggttggcaga aacacttggg cgctttgaag agtataagag tattaagcat taaacatctg      240

aactttcacc gccccaatat actactctag gaaactcgaa aaattccttt ccatgtgtca      300

tcgcttccaa cacactttgc tgtatccttc caagtatgtc cattgtgaac actgatctgg      360

acggaatcct acctttaatc gccaaaggaa aggttagaga catttatgca gtcgatgaga      420

acaacttgct gttcgtcgca actgaccgta tctccgctta cgatgtgatt atgacaaacg      480

gtattcctga taagggaaag attttgactc agctctcagt tttctggttt gattttttgg      540

caccctacat aaagaatcat ttggttgctt ctaatgacaa ggaagtcttt gctttactac      600

catcaaaact gtctgaagaa aaatacaaat ctcaattaga gggacgatcc ttgatagtaa      660

aaaagcacag actgatacct ttggaagcca ttgtcagagg ttacatcact ggaagtgcat      720

ggaaagagta caagaactca aaaactgtcc atggagtcaa ggttgaaaac gagaaccttc      780

aagagagcga cgcctttcca actccgattt tcacaccttc aacgaaagct gaacagggtg      840

aacacgatga aaacatctct attgaacaag ctgctgagat tgtaggtaaa gacatttgtg      900

agaaggtcgc tgtcaaggcg gtcgagttgt attctgctgc aaaaaacctc gcccttttga      960

aggggatcat tattgctgat acgaaattcg aatttggact ggacgaaaac aatgaattgg     1020

tactagtaga tgaagtttta actccagatt cttctagatt ttggaatcaa aagacttacc     1080

aagtgggtaa atcgcaagag agttacgata agcagtttct cagagattgg ttgacggcca     1140

acggattgaa tggcaaagag ggcgtagcca tggatgcaga aattgctatc aagagtaaag     1200

aaaagtatat tgaagcttat gaagcaatta ctggcaagaa atgggcttga                1250


<210>  27
<211>  376
<212>  DNA
<213>  Pichia pastoris

<400>  27
atttacaatt agtaatatta aggtggtaaa aacattcgta gaattgaaat gaattaatat       60

agtatgacaa tggttcatgt ctataaatct ccggcttcgg taccttctcc ccaattgaat      120

acattgtcaa aatgaatggt tgaactatta ggttcgccag tttcgttatt aagaaaactg      180

ttaaaatcaa attccatatc atcggttcca gtgggaggac cagttccatc gccaaaatcc      240

tgtaagaatc cattgtcaga acctgtaaag tcagtttgag atgaaatttt tccggtcttt      300

gttgacttgg aagcttcgtt aaggttaggt gaaacagttt gatcaaccag cggctcccgt      360

tttcgtcgct tagtag                                                      376


<210>  28
<211>  882
<212>  DNA
<213>  Pichia pastoris

<400>  28
atgattagta ccctcctcgc ctttttcaga catctgaaat ttcccttatt cttccaattc       60

catataaaat cctatttagg taattagtaa acaatgatca taaagtgaaa tcattcaagt      120

aaccattccg tttatcgttg atttaaaatc aataacgaat gaatgtcggt ctgagtagtc      180

aatttgttgc cttggagctc attggcaggg ggtcttttgg ctcagtatgg aaggttgaaa      240

ggaaaacaga tggaaagtgg ttcgtcagaa aagaggtatc ctacatgaag atgaatgcca      300

aagagatatc tcaagtgata gctgagttca gaattcttag tgagttaagc catcccaaca      360

ttgtgaagta ccttcatcac gaacatattt ctgagaataa aactgtcaat ttatacatgg      420

aatactgtga tggtggagat ctctccaagc tgattcgaac acatagaagg aacaaagagt      480

acatttcaga agaaaaaata tggagtattt ttacgcaggt tttattagca ttgtatcgtt      540

gtcattatgg aactgatttc acggcttcaa aggagtttga atcgctcaat aaaggtaata      600

gacgaaccca gaatccttcg tgggtagact cgacaagagt tattattcac agggatataa      660

aacccgacaa catctttctg atgaacaatt caaaccttgt caaactggga gattttggat      720

tagcaaaaat tctggaccaa gaaaacgatt ttgccaaaac atacgtcggt acgccgtatt      780

acatgtctcc tgaagtgctg ttggaccaac cctactcacc attatgtgat atatggtctc      840

ttgggtgcgt catgtatgag ctatgtgcat tgaggcctcc tt                         882


<210>  29
<211>  2100
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  29
atgacagctc agttacaaag tgaaagtact tctaaaattg ttttggttac aggtggtgct       60

ggatacattg gttcacacac tgtggtagag ctaattgaga atggatatga ctgtgttgtt      120

gctgataacc tgtcgaattc aacttatgat tctgtagcca ggttagaggt cttgaccaag      180

catcacattc ccttctatga ggttgatttg tgtgaccgaa aaggtctgga aaaggttttc      240

aaagaatata aaattgattc ggtaattcac tttgctggtt taaaggctgt aggtgaatct      300

acacaaatcc cgctgagata ctatcacaat aacattttgg gaactgtcgt tttattagag      360

ttaatgcaac aatacaacgt ttccaaattt gttttttcat cttctgctac tgtctatggt      420

gatgctacga gattcccaaa tatgattcct atcccagaag aatgtccctt agggcctact      480

aatccgtatg gtcatacgaa atacgccatt gagaatatct tgaatgatct ttacaatagc      540

gacaaaaaaa gttggaagtt tgctatcttg cgttatttta acccaattgg cgcacatccc      600

tctggattaa tcggagaaga tccgctaggt ataccaaaca atttgttgcc atatatggct      660

caagtagctg ttggtaggcg cgagaagctt tacatcttcg gagacgatta tgattccaga      720

gatggtaccc cgatcaggga ttatatccac gtagttgatc tagcaaaagg tcatattgca      780

gccctgcaat acctagaggc ctacaatgaa aatgaaggtt tgtgtcgtga gtggaacttg      840

ggttccggta aaggttctac agtttttgaa gtttatcatg cattctgcaa agcttctggt      900

attgatcttc catacaaagt tacgggcaga agagcaggtg atgttttgaa cttgacggct      960

aaaccagata gggccaaacg cgaactgaaa tggcagaccg agttgcaggt tgaagactcc     1020

tgcaaggatt tatggaaatg gactactgag aatccttttg gttaccagtt aaggggtgtc     1080

gaggccagat tttccgctga agatatgcgt tatgacgcaa gatttgtgac tattggtgcc     1140

ggcaccagat ttcaagccac gtttgccaat ttgggcgcca gcattgttga cctgaaagtg     1200

aacggacaat cagttgttct tggctatgaa aatgaggaag ggtatttgaa tcctgatagt     1260

gcttatatag gcgccacgat cggcaggtat gctaatcgta tttcgaaggg taagtttagt     1320

ttatgcaaca aagactatca gttaaccgtt aataacggcg ttaatgcgaa tcatagtagt     1380

atcggttctt tccacagaaa aagatttttg ggacccatca ttcaaaatcc ttcaaaggat     1440

gtttttaccg ccgagtacat gctgatagat aatgagaagg acaccgaatt tccaggtgat     1500

ctattggtaa ccatacagta tactgtgaac gttgcccaaa aaagtttgga aatggtatat     1560

aaaggtaaat tgactgctgg tgaagcgacg ccaataaatt taacaaatca tagttatttc     1620

aatctgaaca agccatatgg agacactatt gagggtacgg agattatggt gcgttcaaaa     1680

aaatctgttg atgtcgacaa aaacatgatt cctacgggta atatcgtcga tagagaaatt     1740

gctaccttta actctacaaa gccaacggtc ttaggcccca aaaatcccca gtttgattgt     1800

tgttttgtgg tggatgaaaa tgctaagcca agtcaaatca atactctaaa caatgaattg     1860

acgcttattg tcaaggcttt tcatcccgat tccaatatta cattagaagt tttaagtaca     1920

gagccaactt atcaatttta taccggtgat ttcttgtctg ctggttacga agcaagacaa     1980

ggttttgcaa ttgagcctgg tagatacatt gatgctatca atcaagagaa ctggaaagat     2040

tgtgtaacct tgaaaaacgg tgaaacttac gggtccaaga ttgtctacag attttcctga     2100


<210>  30
<211>  1037
<212>  DNA
<213>  Pichia pastoris

<400>  30
aaatgcgtac ctcttctacg agattcaagc gaatgagaat aatgtaatat gcaagatcag       60

aaagaatgaa aggagttgaa aaaaaaaacc gttgcgtttt gaccttgaat ggggtggagg      120

tttccattca aagtaaagcc tgtgtcttgg tattttcggc ggcacaagaa atcgtaattt      180

tcatcttcta aacgatgaag atcgcagccc aacctgtatg tagttaaccg gtcggaatta      240

taagaaagat tttcgatcaa caaaccctag caaatagaaa gcagggttac aactttaaac      300

cgaagtcaca aacgataaac cactcagctc ccacccaaat tcattcccac tagcagaaag      360

gaattattta atccctcagg aaacctcgat gattctcccg ttcttccatg ggcgggtatc      420

gcaaaatgag gaatttttca aatttctcta ttgtcaagac tgtttattat ctaagaaata      480

gcccaatccg aagctcagtt ttgaaaaaat cacttccgcg tttctttttt acagcccgat      540

gaatatccaa atttggaata tggattactc tatcgggact gcagataata tgacaacaac      600

gcagattaca ttttaggtaa ggcataaaca ccagccagaa atgaaacgcc cactagccat      660

ggtcgaatag tccaatgaat tcagatagct atggtctaaa agctgatgtt ttttattggg      720

taatggcgaa gagtccagta cgacttccag cagagctgag atggccattt ttgggggtat      780

tagtaacttt ttgagctctt ttcacttcga tgaagtgtcc cattcgggat ataatcggat      840

cgcgtcgttt tctcgaaaat acagcttagc gtcgtccgct tgttgtaaaa gcagcaccac      900

attcctaatc tcttatataa acaaaacaac ccaaattatc agtgctgttt tcccaccaga      960

tataagtttc ttttctcttc cgctttttga ttttttatct ctttccttta aaaacttctt     1020

taccttaaag ggcggcc                                                    1037


<210>  31
<211>  512
<212>  DNA
<213>  Pichia pastoris

<400>  31
taagcttcac gatttgtgtt ccagtttatc ccccctttat ataccgttaa ccctttccct       60

gttgagctga ctgttgttgt attaccgcaa tttttccaag tttgccatgc ttttcgtgtt      120

atttgaccga tgtctttttt cccaaatcaa actatatttg ttaccattta aaccaagtta      180

tcttttgtat taagagtcta agtttgttcc caggcttcat gtgagagtga taaccatcca      240

gactatgatt cttgtttttt attgggtttg tttgtgtgat acatctgagt tgtgattcgt      300

aaagtatgtc agtctatcta gatttttaat agttaattgg taatcaatga cttgtttgtt      360

ttaactttta aattgtgggt cgtatccacg cgtttagtat agctgttcat ggctgttaga      420

ggagggcgat gtttatatac agaggacaag aatgaggagg cggcgtgtat ttttaaaatg      480

gagacgcgac tcctgtacac cttatcggtt gg                                    512


<210>  32
<211>  1068
<212>  DNA
<213>  Homo sapiens

<400>  32
ggtagagatt tgtctagatt gccacagttg gttggtgttt ccactccatt gcaaggaggt       60

tctaactctg ctgctgctat tggtcaatct tccggtgagt tgagaactgg tggagctaga      120

ccacctccac cattgggagc ttcctctcaa ccaagaccag gtggtgattc ttctccagtt      180

gttgactctg gtccaggtcc agcttctaac ttgacttccg ttccagttcc acacactact      240

gctttgtcct tgccagcttg tccagaagaa tccccattgt tggttggtcc aatgttgatc      300

gagttcaaca tgccagttga cttggagttg gttgctaagc agaacccaaa cgttaagatg      360

ggtggtagat acgctccaag agactgtgtt tccccacaca aagttgctat catcatccca      420

ttcagaaaca gacaggagca cttgaagtac tggttgtact acttgcaccc agttttgcaa      480

agacagcagt tggactacgg tatctacgtt atcaaccagg ctggtgacac tattttcaac      540

agagctaagt tgttgaatgt tggtttccag gaggctttga aggattacga ctacacttgt      600

ttcgttttct ccgacgttga cttgattcca atgaacgacc acaacgctta cagatgtttc      660

tcccagccaa gacacatttc tgttgctatg gacaagttcg gtttctcctt gccatacgtt      720

caatacttcg gtggtgtttc cgctttgtcc aagcagcagt tcttgactat caacggtttc      780

ccaaacaatt actggggatg gggtggtgaa gatgacgaca tctttaacag attggttttc      840

agaggaatgt ccatctctag accaaacgct gttgttggta gatgtagaat gatcagacac      900

tccagagaca agaagaacga gccaaaccca caaagattcg acagaatcgc tcacactaag      960

gaaactatgt tgtccgacgg attgaactcc ttgacttacc aggttttgga cgttcagaga     1020

tacccattgt acactcagat cactgttgac atcggtactc catcctag                  1068


<210>  33
<211>  183
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  33
atggccctct ttctcagtaa gagactgttg agatttaccg tcattgcagg tgcggttatt       60

gttctcctcc taacattgaa ttccaacagt agaactcagc aatatattcc gagttccatc      120

tccgctgcat ttgattttac ctcaggatct atatcccctg aacaacaagt catcgggcgc      180

gcc                                                                    183


<210>  34
<211>  1074
<212>  DNA
<213>  Drosophila melanogaster

<400>  34
atgaatagca tacacatgaa cgccaatacg ctgaagtaca tcagcctgct gacgctgacc       60

ctgcagaatg ccatcctggg cctcagcatg cgctacgccc gcacccggcc aggcgacatc      120

ttcctcagct ccacggccgt actcatggca gagttcgcca aactgatcac gtgcctgttc      180

ctggtcttca acgaggaggg caaggatgcc cagaagtttg tacgctcgct gcacaagacc      240

atcattgcga atcccatgga cacgctgaag gtgtgcgtcc cctcgctggt ctatatcgtt      300

caaaacaatc tgctgtacgt ctctgcctcc catttggatg cggccaccta ccaggtgacg      360

taccagctga agattctcac cacggccatg ttcgcggttg tcattctgcg ccgcaagctg      420

ctgaacacgc agtggggtgc gctgctgctc ctggtgatgg gcatcgtcct ggtgcagttg      480

gcccaaacgg agggtccgac gagtggctca gccggtggtg ccgcagctgc agccacggcc      540

gcctcctctg gcggtgctcc cgagcagaac aggatgctcg gactgtgggc cgcactgggc      600

gcctgcttcc tctccggatt cgcgggcatc tactttgaga agatcctcaa gggtgccgag      660

atctccgtgt ggatgcggaa tgtgcagttg agtctgctca gcattccctt cggcctgctc      720

acctgtttcg ttaacgacgg cagtaggatc ttcgaccagg gattcttcaa gggctacgat      780

ctgtttgtct ggtacctggt cctgctgcag gccggcggtg gattgatcgt tgccgtggtg      840

gtcaagtacg cggataacat tctcaagggc ttcgccacct cgctggccat catcatctcg      900

tgcgtggcct ccatatacat cttcgacttc aatctcacgc tgcagttcag cttcggagct      960

ggcctggtca tcgcctccat atttctctac ggctacgatc cggccaggtc ggcgccgaag     1020

ccaactatgc atggtcctgg cggcgatgag gagaagctgc tgccgcgcgt ctag           1074


<210>  35
<211>  798
<212>  DNA
<213>  Pichia pastoris

<400>  35
tggacacagg agactcagaa acagacacag agcgttctga gtcctggtgc tcctgacgta       60

ggcctagaac aggaattatt ggctttattt gtttgtccat ttcataggct tggggtaata      120

gatagatgac agagaaatag agaagaccta atattttttg ttcatggcaa atcgcgggtt      180

cgcggtcggg tcacacacgg agaagtaatg agaagagctg gtaatctggg gtaaaagggt      240

tcaaaagaag gtcgcctggt agggatgcaa tacaaggttg tcttggagtt tacattgacc      300

agatgatttg gctttttctc tgttcaattc acatttttca gcgagaatcg gattgacgga      360

gaaatggcgg ggtgtggggt ggatagatgg cagaaatgct cgcaatcacc gcgaaagaaa      420

gactttatgg aatagaacta ctgggtggtg taaggattac atagctagtc caatggagtc      480

cgttggaaag gtaagaagaa gctaaaaccg gctaagtaac tagggaagaa tgatcagact      540

ttgatttgat gaggtctgaa aatactctgc tgctttttca gttgcttttt ccctgcaacc      600

tatcattttc cttttcataa gcctgccttt tctgttttca cttatatgag ttccgccgag      660

acttccccaa attctctcct ggaacattct ctatcgctct ccttccaagt tgcgccccct      720

ggcactgcct agtaatatta ccacgcgact tatattcagt tccacaattt ccagtgttcg      780

tagcaaatat catcagcc                                                    798


<210>  36
<211>  302
<212>  DNA
<213>  Pichia pastoris

<400>  36
aatatatacc tcatttgttc aatttggtgt aaagagtgtg gcggatagac ttcttgtaaa       60

tcaggaaagc tacaattcca attgctgcaa aaaataccaa tgcccataaa ccagtatgag      120

cggtgccttc gacggattgc ttactttccg accctttgtc gtttgattct tctgcctttg      180

gtgagtcagt ttgtttcgac tttatatctg actcatcaac ttcctttacg gttgcgtttt      240

taatcataat tttagccgtt ggcttattat cccttgagtt ggtaggagtt ttgatgatgc      300

tg                                                                     302


<210>  37
<211>  461
<212>  DNA
<213>  Pichia pastoris

<400>  37
taactggccc tttgacgttt ctgacaatag ttctagagga gtcgtccaaa aactcaactc       60

tgacttgggt gacaccacca cgggatccgg ttcttccgag gaccttgatg accttggcta      120

atgtaactgg agttttagta tccattttaa gatgtgtgtt tctgtaggtt ctgggttgga      180

aaaaaatttt agacaccaga agagaggagt gaactggttt gcgtgggttt agactgtgta      240

aggcactact ctgtcgaagt tttagatagg ggttacccgc tccgatgcat gggaagcgat      300

tagcccggct gttgcccgtt tggtttttga agggtaattt tcaatatctc tgtttgagtc      360

atcaatttca tattcaaaga ttcaaaaaca aaatctggtc caaggagcgc atttaggatt      420

atggagttgg cgaatcactt gaacgataga ctattatttg c                          461


<210>  38
<211>  1841
<212>  DNA
<213>  Pichia pastoris

<400>  38
gtgacattct tgtctttgag atcagtaatt gtagagcata gatagaataa tattcaagac       60

caacggcttc tcttcggaag ctccaagtag cttatagtga tgagtaccgg catatattta      120

taggcttaaa atttcgaggg ttcactatat tcgtttagtg ggaagagttc ctttcactct      180

tgttatctat attgtcagcg tggactgttt ataactgtac caacttagtt tctttcaact      240

ccaggttaag agacataaat gtcctttgat gctgacaata atcagtggaa ttcaaggaag      300

gacaatcccg acctcaatct gttcattaat gaagagttcg aatcgtcctt aaatcaagcg      360

ctagactcaa ttgtcaatga gaaccctttc tttgaccaag aaactataaa tagatcgaat      420

gacaaagttg gaaatgagtc cattagctta catgatattg agcaggcaga ccaaaataaa      480

ccgtcctttg agagcgatat tgatggttcg gcgccgttga taagagacga caaattgcca      540

aagaaacaaa gctgggggct gagcaatttt ttttcaagaa gaaatagcat atgtttacca      600

ctacatgaaa atgattcaag tgttgttaag accgaaagat ctattgcagt gggaacaccc      660

catcttcaat actgcttcaa tggaatctcc aatgccaagt acaatgcatt tacctttttc      720

ccagtcatcc tatacgagca attcaaattt tttttcaatt tatactttac tttagtggct      780

ctctctcaag cgataccgca acttcgcatt ggatatcttt cttcgtatgt cgtcccactt      840

ttgtttgtac tcatagtgac catgtcaaaa gaggcgatgg atgatattca acgccgaaga      900

agggatagag aacagaacaa tgaaccatat gaggttctgt ccagcccatc accagttttg      960

tccaaaaact taaaatgtgg tcacttggtt cgattgcata agggaatgag agtgcccgca     1020

gatatggttc ttgtccagtc aagcgaatcc accggagagt catttatcaa gacagatcag     1080

ctggatggtg agactgattg gaagcttcgg attgtttctc cagttacaca atcgttacca     1140

atgactgaac ttcaaaatgt cgccatcact gcaagcgcac cctcaaaatc aattcactcc     1200

tttcttggaa gattgaccta caatgggcaa tcatatggtc ttacgataga caacacaatg     1260

tggtgtaata ctgtattagc ttctggttca gcaattggtt gtataattta cacaggtaaa     1320

gatactcgac aatcgatgaa cacaactcag cccaaactga aaacgggctt gttagaactg     1380

gaaatcaata gtttgtccaa gatcttatgt gtttgtgtgt ttgcattatc tgtcatctta     1440

gtgctattcc aaggaatagc tgatgattgg tacgtcgata tcatgcggtt tctcattcta     1500

ttctccacta ttatcccagt gtctctgaga gttaaccttg atcttggaaa gtcagtccat     1560

gctcatcaaa tagaaactga tagctcaata cctgaaaccg ttgttagaac tagtacaata     1620

ccggaagacc tgggaagaat tgaataccta ttaagtgaca aaactggaac tcttactcaa     1680

aatgatatgg aaatgaaaaa actacaccta ggaacagtct cttatgctgg tgataccatg     1740

gatattattt ctgatcatgt taaaggtctt aataacgcta aaacatcgag gaaagatctt     1800

ggtatgagaa taagagattt ggttacaact ctggccatct g                         1841


<210>  39
<211>  3105
<212>  DNA
<213>  Drosophila melanogaster

<400>  39
agagacgatc caattagacc tccattgaag gttgctagat ccccaagacc aggtcaatgt       60

caagatgttg ttcaggacgt cccaaacgtt gatgtccaga tgttggagtt gtacgataga      120

atgtccttca aggacattga tggtggtgtt tggaagcagg gttggaacat taagtacgat      180

ccattgaagt acaacgctca tcacaagttg aaggtcttcg ttgtcccaca ctcccacaac      240

gatcctggtt ggattcagac cttcgaggaa tactaccagc acgacaccaa gcacatcttg      300

tccaacgctt tgagacattt gcacgacaac ccagagatga agttcatctg ggctgaaatc      360

tcctacttcg ctagattcta ccacgatttg ggtgagaaca agaagttgca gatgaagtcc      420

atcgtcaaga acggtcagtt ggaattcgtc actggtggat gggtcatgcc agacgaggct      480

aactcccact ggagaaacgt tttgttgcag ttgaccgaag gtcaaacttg gttgaagcaa      540

ttcatgaacg tcactccaac tgcttcctgg gctatcgatc cattcggaca ctctccaact      600

atgccataca ttttgcagaa gtctggtttc aagaatatgt tgatccagag aacccactac      660

tccgttaaga aggagttggc tcaacagaga cagttggagt tcttgtggag acagatctgg      720

gacaacaaag gtgacactgc tttgttcacc cacatgatgc cattctactc ttacgacatt      780

cctcatacct gtggtccaga tccaaaggtt tgttgtcagt tcgatttcaa aagaatgggt      840

tccttcggtt tgtcttgtcc atggaaggtt ccacctagaa ctatctctga tcaaaatgtt      900

gctgctagat ccgatttgtt ggttgatcag tggaagaaga aggctgagtt gtacagaacc      960

aacgtcttgt tgattccatt gggtgacgac ttcagattca agcagaacac cgagtgggat     1020

gttcagagag tcaactacga aagattgttc gaacacatca actctcaggc tcacttcaat     1080

gtccaggctc agttcggtac tttgcaggaa tacttcgatg ctgttcacca ggctgaaaga     1140

gctggacaag ctgagttccc aaccttgtct ggtgacttct tcacttacgc tgatagatct     1200

gataactact ggtctggtta ctacacttcc agaccatacc ataagagaat ggacagagtc     1260

ttgatgcact acgttagagc tgctgaaatg ttgtccgctt ggcactcctg ggacggtatg     1320

gctagaatcg aggaaagatt ggagcaggct agaagagagt tgtccttgtt ccagcaccac     1380

gacggtatta ctggtactgc taaaactcac gttgtcgtcg actacgagca aagaatgcag     1440

gaagctttga aagcttgtca aatggtcatg caacagtctg tctacagatt gttgactaag     1500

ccatccatct actctccaga cttctccttc tcctacttca ctttggacga ctccagatgg     1560

ccaggttctg gtgttgagga ctctagaact accatcatct tgggtgagga tatcttgcca     1620

tccaagcatg ttgtcatgca caacaccttg ccacactgga gagagcagtt ggttgacttc     1680

tacgtctcct ctccattcgt ttctgttacc gacttggcta acaatccagt tgaggctcag     1740

gtttctccag tttggtcttg gcaccacgac actttgacta agactatcca cccacaaggt     1800

tccaccacca agtacagaat catcttcaag gctagagttc caccaatggg tttggctacc     1860

tacgttttga ccatctccga ttccaagcca gagcacacct cctacgcttc caatttgttg     1920

cttagaaaga acccaacttc cttgccattg ggtcaatacc cagaggatgt caagttcggt     1980

gatccaagag agatctcctt gagagttggt aacggtccaa ccttggcttt ctctgagcag     2040

ggtttgttga agtccattca gttgactcag gattctccac atgttccagt tcacttcaag     2100

ttcttgaagt acggtgttag atctcatggt gatagatctg gtgcttactt gttcttgcca     2160

aatggtccag cttctccagt cgagttgggt cagccagttg tcttggtcac taagggtaaa     2220

ttggagtctt ccgtttctgt tggtttgcca tctgtcgttc accagaccat catgagaggt     2280

ggtgctccag agattagaaa tttggtcgat attggttctt tggacaacac tgagatcgtc     2340

atgagattgg agactcatat cgactctggt gatatcttct acactgattt gaatggattg     2400

caattcatca agaggagaag attggacaag ttgccattgc aggctaacta ctacccaatt     2460

ccatctggta tgttcattga ggatgctaat accagattga ctttgttgac cggtcaacca     2520

ttgggtggat cttctttggc ttctggtgag ttggagatta tgcaagatag aagattggct     2580

tctgatgatg aaagaggttt gggtcagggt gttttggaca acaagccagt tttgcatatt     2640

tacagattgg tcttggagaa ggttaacaac tgtgtcagac catctaagtt gcatccagct     2700

ggttacttga cttctgctgc tcacaaagct tctcagtctt tgttggatcc attggacaag     2760

ttcatcttcg ctgaaaatga gtggatcggt gctcagggtc aattcggtgg tgatcatcca     2820

tctgctagag aggatttgga tgtctctgtc atgagaagat tgaccaagtc ttctgctaaa     2880

acccagagag ttggttacgt tttgcacaga accaatttga tgcaatgtgg tactccagag     2940

gagcatactc agaagttgga tgtctgtcac ttgttgccaa atgttgctag atgtgagaga     3000

actaccttga ctttcttgca gaatttggag cacttggatg gtatggttgc tccagaagtt     3060

tgtccaatgg aaaccgctgc ttacgtctct tctcactctt cttga                     3105


<210>  40
<211>  108
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  40
atgctgctta ccaaaaggtt ttcaaagctg ttcaagctga cgttcatagt tttgatattg       60

tgcgggctgt tcgtcattac aaacaaatac atggatgaga acacgtcg                   108


<210>  41
<211>  1729
<212>  DNA
<213>  Pichia pastoris

<400>  41
caagttgcgt ccggtatacg taacgtctca cgatgatcaa agataatact taatcttcat       60

ggtctactga ataactcatt taaacaattg actaattgta cattatattg aacttatgca      120

tcctattaac gtaatcttct ggcttctctc tcagactcca tcagacacag aatatcgttc      180

tctctaactg gtcctttgac gtttctgaca atagttctag aggagtcgtc caaaaactca      240

actctgactt gggtgacacc accacgggat ccggttcttc cgaggacctt gatgaccttg      300

gctaatgtaa ctggagtttt agtatccatt ttaagatgtg tgtttctgta ggttctgggt      360

tggaaaaaaa ttttagacac cagaagagag gagtgaactg gtttgcgtgg gtttagactg      420

tgtaaggcac tactctgtcg aagttttaga taggggttac ccgctccgat gcatgggaag      480

cgattagccc ggctgttgcc cgtttggttt ttgaagggta attttcaata tctctgtttg      540

agtcatcaat ttcatattca aagattcaaa aacaaaatct ggtccaagga gcgcatttag      600

gattatggag ttggcgaatc acttgaacga tagactatta tttgctgttc ctaaagaggg      660

cagattgtat gagaaatgcg ttgaattact taggggatca gatattcagt ttcgaagatc      720

cagtagattg gatatagctt tgtgcactaa cctgcccctg gcattggttt tccttccagc      780

tgctgacatt cccacgtttg taggagaggg taaatgtgat ttgggtataa ctggtattga      840

ccaggttcag gaaagtgacg tagatgtcat acctttatta gacttgaatt tcggtaagtg      900

caagttgcag attcaagttc ccgagaatgg tgacttgaaa gaacctaaac agctaattgg      960

taaagaaatt gtttcctcct ttactagctt aaccaccagg tactttgaac aactggaagg     1020

agttaagcct ggtgagccac taaagacaaa aatcaaatat gttggagggt ctgttgaggc     1080

ctcttgtgcc ctaggagttg ccgatgctat tgtggatctt gttgagagtg gagaaaccat     1140

gaaagcggca gggctgatcg atattgaaac tgttctttct acttccgctt acctgatctc     1200

ttcgaagcat cctcaacacc cagaactgat ggatactatc aaggagagaa ttgaaggtgt     1260

actgactgct cagaagtatg tcttgtgtaa ttacaacgca cctagaggta accttcctca     1320

gctgctaaaa ctgactccag gcaagagagc tgctaccgtt tctccattag atgaagaaga     1380

ttgggtggga gtgtcctcga tggtagagaa gaaagatgtt ggaagaatca tggacgaatt     1440

aaagaaacaa ggtgccagtg acattcttgt ctttgagatc agtaattgta gagcatagat     1500

agaataatat tcaagaccaa cggcttctct tcggaagctc caagtagctt atagtgatga     1560

gtaccggcat atatttatag gcttaaaatt tcgagggttc actatattcg tttagtggga     1620

agagttcctt tcactcttgt tatctatatt gtcagcgtgg actgtttata actgtaccaa     1680

cttagtttct ttcaactcca ggttaagaga cataaatgtc ctttgatgc                 1729


<210>  42
<211>  1068
<212>  DNA
<213>  Rattus

<400>  42
tccttggttt accaattgaa cttcgaccag atgttgagaa acgttgacaa ggacggtact       60

tggtctcctg gtgagttggt tttggttgtt caggttcaca acagaccaga gtacttgaga      120

ttgttgatcg actccttgag aaaggctcaa ggtatcagag aggttttggt tatcttctcc      180

cacgatttct ggtctgctga gatcaactcc ttgatctcct ccgttgactt ctgtccagtt      240

ttgcaggttt tcttcccatt ctccatccaa ttgtacccat ctgagttccc aggttctgat      300

ccaagagact gtccaagaga cttgaagaag aacgctgctt tgaagttggg ttgtatcaac      360

gctgaatacc cagattcttt cggtcactac agagaggcta agttctccca aactaagcat      420

cattggtggt ggaagttgca ctttgtttgg gagagagtta aggttttgca ggactacact      480

ggattgatct tgttcttgga ggaggatcat tacttggctc cagacttcta ccacgttttc      540

aagaagatgt ggaagttgaa gcaacaagag tgtccaggtt gtgacgtttt gtccttggga      600

acttacacta ctatcagatc cttctacggt atcgctgaca aggttgacgt taagacttgg      660

aagtccactg aacacaacat gggattggct ttgactagag atgcttacca gaagttgatc      720

gagtgtactg acactttctg tacttacgac gactacaact gggactggac tttgcagtac      780

ttgactttgg cttgtttgcc aaaagtttgg aaggttttgg ttccacaggc tccaagaatt      840

ttccacgctg gtgactgtgg aatgcaccac aagaaaactt gtagaccatc cactcagtcc      900

gctcaaattg agtccttgtt gaacaacaac aagcagtact tgttcccaga gactttggtt      960

atcggagaga agtttccaat ggctgctatt tccccaccaa gaaagaatgg tggatggggt     1020

gatattagag accacgagtt gtgtaaatcc tacagaagat tgcagtag                  1068


<210>  43
<211>  300
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  43
atgctgctta ccaaaaggtt ttcaaagctg ttcaagctga cgttcatagt tttgatattg       60

tgcgggctgt tcgtcattac aaacaaatac atggatgaga acacgtcggt caaggagtac      120

aaggagtact tagacagata tgtccagagt tactccaata agtattcatc ttcctcagac      180

gccgccagcg ctgacgattc aaccccattg agggacaatg atgaggcagg caatgaaaag      240

ttgaaaagct tctacaacaa cgttttcaac tttctaatgg ttgattcgcc cgggcgcgcc      300


<210>  44
<211>  1373
<212>  DNA
<213>  Pichia pastoris

<400>  44
gatctggcct tccctgaatt tttacgtcca gctatacgat ccgttgtgac tgtatttcct       60

gaaatgaagt ttcaacctaa agttttggtt gtacttgctc cacctaccac ggaaactaat      120

atcgaaacca atgaaaaagt agaactggaa tcgtcaatcg aaattcgcaa ccaagtggaa      180

cccaaagact tgaatctttc taaagtctat tctagtgaca ctaatggcaa cagaagattt      240

gagctgactt ttcaaatgaa tctcaataat gcaatatcaa catcagacaa tcaatgggct      300

ttgtctagtg acacaggatc aattatagta gtgtcttctg caggaagaat aacttccccg      360

atcctagaag tcggggcatc cgtctgtgtc ttaagatcgt acaacgaaca ccttttggca      420

ataacttgtg aaggaacatg cttttcatgg aatttaaaga agcaagaatg tgttctaaac      480

agcatttcat tagcacctat agtcaattca cacatgctag ttaagaaagt tggagatgca      540

aggaactatt ctattgtatc tgccgaagga gacaacaatc cgttacccca gattctagac      600

tgcgaacttt ccaaaaatgg cgctccaatt gtggctctta gcacgaaaga catctactct      660

tattcaaaga aaatgaaatg ctggatccat ttgattgatt cgaaatactt tgaattgttg      720

ggtgctgaca atgcactgtt tgagtgtgtg gaagcgctag aaggtccaat tggaatgcta      780

attcatagat tggtagatga gttcttccat gaaaacactg ccggtaaaaa actcaaactt      840

tacaacaagc gagtactgga ggacctttca aattcacttg aagaactagg tgaaaatgcg      900

tctcaattaa gagagaaact tgacaaactc tatggtgatg aggttgaggc ttcttgacct      960

cttctctcta tctgcgtttc tttttttttt tttttttttt tttttttcag ttgagccaga     1020

ccgcgctaaa cgcataccaa ttgccaaatc aggcaattgt gagacagtgg taaaaaagat     1080

gcctgcaaag ttagattcac acagtaagag agatcctact cataaatgag gcgcttattt     1140

agtagctagt gatagccact gcggttctgc tttatgctat ttgttgtatg ccttactatc     1200

tttgtttggc tcctttttct tgacgttttc cgttggaggg actccctatt ctgagtcatg     1260

agccgcacag attatcgccc aaaattgaca aaatcttctg gcgaaaaaag tataaaagga     1320

gaaaaaagct cacccttttc cagcgtagaa agtatatatc agtcattgaa gac            1373


<210>  45
<211>  1470
<212>  DNA
<213>  Pichia pastoris

<400>  45
gggactttaa ctcaagtaaa aggatagttg tacaattata tatacgaaga ataaatcatt       60

acaaaaagta ttcgtttctt tgattcttaa caggattcat tttctgggtg tcatcaggta      120

cagcgctgaa tatcttgaag ttaacatcga gctcatcatc gacgttcatc acactagcca      180

cgtttccgca acggtagcaa taattaggag cggaccacac agtgacgaca tctttctctt      240

tgaaatggta tctgaagcct tccatgacca attgatgggc tctagcgatg agttgcaagt      300

tattaatgtg gttgaactca cgtgctactc gagcaccgaa taaccagcca gctccacgag      360

gagaaacagc ccaactgtcg acttcatctg ggtcagacca aaccaagtca caaaatcctc      420

cttcatgagg gacctcttgc gctcggctga gaactctgat ttgatctaac atgcgaatat      480

cgggagagag accaccatgg atacataata ttttaccatc aatgatggca ctaagggtta      540

aaaagtcgaa cacctggcaa cagtacttcc agacagtggt ggaaccatat ttattgagac      600

attcctcata aaatccataa acctgagtga tctgtctgga ttcatgattt ccccttacca      660

atgtgatatg ttgaggaaac ttaattttta aaatcatgag taacgtgaac gtctccaacg      720

agaaatagcc tctatccaca tagtctccta ggaagatata gttctgtttt attccattag      780

aggaggatcc gggaaaccca ccactaatct tgaaaagttc cagtagatcg tgaaattggc      840

cgtgaatatc tccgcatact gtcactggac tctgcactgg ctgtatattg gattcctcca      900

tcagcaaatc cttcacccgt tcgcaaagat gcttcatatc attttcactt aaagccttgc      960

agcttttgac ttcttcaaac cactgatctg gtcctctttc tggcatgatt aaggtctata     1020

atatttctga gctgagatgt aaaaaaaaat aataaaaatg gggagtgaaa aagtgtgtag     1080

cttttaggag tttgggattg ataccccaaa atgatcttta tgagaattaa aaggtagata     1140

cgcttttaat aagaacacct atctatagta ctttgtggtc ttgagtaatt gagatgttca     1200

gcttctgagg tttgccgtta ttctgggata gtagtgcgcg accaaacaac ccgccaggca     1260

aagtgtgttg tgctcgaaga cgattgccag aagagtaagt ccgtcctgcc tcagatgtta     1320

cacactttct tccctagaca gtcgatgcat catcggattt aaacctgaaa ctttgatgcc     1380

atgatacgcc tagtcacgtc gactgagatt ttagataagc cccgatccct ttagtacatt     1440

cctgttatcc atggatggaa tggcctgata                                      1470


<210>  46
<211>  1043
<212>  DNA
<213>  Pichia pastoris

<400>  46
aagcttgttc accgttggga cttttccgtg gacaatgttg actactccag gagggattcc       60

agctttctct actagctcag caataatcaa tgcagcccca ggcgcccgtt ctgatggctt      120

gatgaccgtt gtattgcctg tcactatagc caggggtagg gtccataaag gaatcatagc      180

agggaaatta aaagggcata ttgatgcaat cactcccaat ggctctcttg ccattgaagt      240

ctccatatca gcactaactt ccaagaagga ccccttcaag tctgacgtga tagagcacgc      300

ttgctctgcc acctgtagtc ctctcaaaac gtcaccttgt gcatcagcaa agactttacc      360

ttgctccaat actatgacgg aggcaattct gtcaaaattc tctctcagca attcaaccaa      420

cttgaaagca aattgctgtc tcttgatgat ggagactttt ttccaagatt gaaatgcaat      480

gtgggacgac tcaattgctt cttccagctc ctcttcggtt gattgaggaa cttttgaaac      540

cacaaaattg gtcgttgggt catgtacatc aaaccattct gtagatttag attcgacgaa      600

agcgttgttg atgaaggaaa aggttggata cggtttgtcg gtctctttgg tatggccggt      660

ggggtatgca attgcagtag aagataattg gacagccatt gttgaaggta gagaaaaggt      720

cagggaactt gggggttatt tataccattt taccccacaa ataacaactg aaaagtaccc      780

attccatagt gagaggtaac cgacggaaaa agacgggccc atgttctggg accaatagaa      840

ctgtgtaatc cattgggact aatcaacaga cgattggcaa tataatgaaa tagttcgttg      900

aaaagccacg tcagctgtct tttcattaac tttggtcgga cacaacattt tctactgttg      960

tatctgtcct actttgctta tcatctgcca cagggcaagt ggatttcctt ctcgcgcggc     1020

tgggtgaaaa cggttaacgt gaa                                             1043


<210>  47
<211>  695
<212>  DNA
<213>  Pichia pastoris

<400>  47
gccttggggg acttcaagtc tttgctagaa actagatgag gtcaggccct cttatggttg       60

tgtcccaatt gggcaatttc actcacctaa aaagcatgac aattatttag cgaaataggt      120

agtatatttt ccctcatctc ccaagcagtt tcgtttttgc atccatatct ctcaaatgag      180

cagctacgac tcattagaac cagagtcaag taggggtgag ctcagtcatc agccttcgtt      240

tctaaaacga ttgagttctt ttgttgctac aggaagcgcc ctagggaact ttcgcacttt      300

ggaaatagat tttgatgacc aagagcggga gttgatatta gagaggctgt ccaaagtaca      360

tgggatcagg ccggccaaat tgattggtgt gactaaacca ttgtgtactt ggacactcta      420

ttacaaaagc gaagatgatt tgaagtatta caagtcccga agtgttagag gattctatcg      480

agcccagaat gaaatcatca accgttatca gcagattgat aaactcttgg aaagcggtat      540

cccattttca ttattgaaga actacgataa tgaagatgtg agagacggcg accctctgaa      600

cgtagacgaa gaaacaaatc tacttttggg gtacaataga gaaagtgaat caagggaggt      660

atttgtggcc ataatactca actctatcat taatg                                 695


<210>  48
<211>  411
<212>  DNA
<213>  Pichia pastoris

<400>  48
catatggtga gagccgttct gcacaactag atgttttcga gcttcgcatt gtttcctgca       60

gctcgactat tgaattaaga tttccggata tctccaatct cacaaaaact tatgttgacc      120

acgtgctttc ctgaggcgag gtgttttata tgcaagctgc caaaaatgga aaacgaatgg      180

ccatttttcg cccaggcaaa ttattcgatt actgctgtca taaagacagt gttgcaaggc      240

tcacattttt ttttaggatc cgagataaag tgaatacagg acagcttatc tctatatctt      300

gtaccattcg tgaatcttaa gagttcggtt agggggactc tagttgaggg ttggcactca      360

cgtatggctg ggcgcagaaa taaaattcag gcgcagcagc acttatcgat g               411


<210>  49
<211>  692
<212>  DNA
<213>  Pichia pastoris

<400>  49
gaattcacag ttataaataa aaacaaaaac tcaaaaagtt tgggctccac aaaataactt       60

aatttaaatt tttgtctaat aaatgaatgt aattccaaga ttatgtgatg caagcacagt      120

atgcttcagc cctatgcagc tactaatgtc aatctcgcct gcgagcgggc ctagattttc      180

actacaaatt tcaaaactac gcggatttat tgtctcagag agcaatttgg catttctgag      240

cgtagcagga ggcttcataa gattgtatag gaccgtacca acaaattgcc gaggcacaac      300

acggtatgct gtgcacttat gtggctactt ccctacaacg gaatgaaacc ttcctctttc      360

cgcttaaacg agaaagtgtg tcgcaattga atgcaggtgc ctgtgcgcct tggtgtattg      420

tttttgaggg cccaatttat caggcgcctt ttttcttggt tgttttccct tagcctcaag      480

caaggttggt ctatttcatc tccgcttcta taccgtgcct gatactgttg gatgagaaca      540

cgactcaact tcctgctgct ctgtattgcc agtgttttgt ctgtgatttg gatcggagtc      600

ctccttactt ggaatgataa taatcttggc ggaatctccc taaacggagg caaggattct      660

gcctatgatg atctgctatc attgggaagc tt                                    692


<210>  50
<211>  546
<212>  DNA
<213>  Pichia pastoris

<400>  50
gatatctccc tggggacaat atgtgttgca actgttcgtt gttggtgccc cagtccccca       60

accggtacta atcggtctat gttcccgtaa ctcatattcg gttagaacta gaacaataag      120

tgcatcattg ttcaacattg tggttcaatt gtcgaacatt gctggtgctt atatctacag      180

ggaagacgat aagcctttgt acaagagagg taacagacag ttaattggta tttctttggg      240

agtcgttgcc ctctacgttg tctccaagac atactacatt ctgagaaaca gatggaagac      300

tcaaaaatgg gagaagctta gtgaagaaga gaaagttgcc tacttggaca gagctgagaa      360

ggagaacctg ggttctaaga ggctggactt tttgttcgag agttaaactg cataattttt      420

tctaagtaaa tttcatagtt atgaaatttc tgcagcttag tgtttactgc atcgtttact      480

gcatcaccct gtaaataatg tgagcttttt tccttccatt gcttggtatc ttccttgctg      540

ctgttt                                                                 546


<210>  51
<211>  378
<212>  DNA
<213>  Pichia pastoris

<400>  51
acaaaacagt catgtacaga actaacgcct ttaagatgca gaccactgaa aagaattggg       60

tcccattttt cttgaaagac gaccaggaat ctgtccattt tgtttactcg ttcaatcctc      120

tgagagtact caactgcagt cttgataacg gtgcatgtga tgttctattt gagttaccac      180

atgattttgg catgtcttcc gagctacgtg gtgccactcc tatgctcaat cttcctcagg      240

caatcccgat ggcagacgac aaagaaattt gggtttcatt cccaagaacg agaatatcag      300

attgcgggtg ttctgaaaca atgtacaggc caatgttaat gctttttgtt agagaaggaa      360

caaacttttt tgctgagc                                                    378


<210>  52
<211>  1494
<212>  DNA
<213>  Trichoderma reesei

<400>  52
cgcgccggat ctcccaaccc tacgagggcg gcagcagtca aggccgcatt ccagacgtcg       60

tggaacgctt accaccattt tgcctttccc catgacgacc tccacccggt cagcaacagc      120

tttgatgatg agagaaacgg ctggggctcg tcggcaatcg atggcttgga cacggctatc      180

ctcatggggg atgccgacat tgtgaacacg atccttcagt atgtaccgca gatcaacttc      240

accacgactg cggttgccaa ccaaggcatc tccgtgttcg agaccaacat tcggtacctc      300

ggtggcctgc tttctgccta tgacctgttg cgaggtcctt tcagctcctt ggcgacaaac      360

cagaccctgg taaacagcct tctgaggcag gctcaaacac tggccaacgg cctcaaggtt      420

gcgttcacca ctcccagcgg tgtcccggac cctaccgtct tcttcaaccc tactgtccgg      480

agaagtggtg catctagcaa caacgtcgct gaaattggaa gcctggtgct cgagtggaca      540

cggttgagcg acctgacggg aaacccgcag tatgcccagc ttgcgcagaa gggcgagtcg      600

tatctcctga atccaaaggg aagcccggag gcatggcctg gcctgattgg aacgtttgtc      660

agcacgagca acggtacctt tcaggatagc agcggcagct ggtccggcct catggacagc      720

ttctacgagt acctgatcaa gatgtacctg tacgacccgg ttgcgtttgc acactacaag      780

gatcgctggg tccttgctgc cgactcgacc attgcgcatc tcgcctctca cccgtcgacg      840

cgcaaggact tgaccttttt gtcttcgtac aacggacagt ctacgtcgcc aaactcagga      900

catttggcca gttttgccgg tggcaacttc atcttgggag gcattctcct gaacgagcaa      960

aagtacattg actttggaat caagcttgcc agctcgtact ttgccacgta caaccagacg     1020

gcttctggaa tcggccccga aggcttcgcg tgggtggaca gcgtgacggg cgccggcggc     1080

tcgccgccct cgtcccagtc cgggttctac tcgtcggcag gattctgggt gacggcaccg     1140

tattacatcc tgcggccgga gacgctggag agcttgtact acgcataccg cgtcacgggc     1200

gactccaagt ggcaggacct ggcgtgggaa gcgttcagtg ccattgagga cgcatgccgc     1260

gccggcagcg cgtactcgtc catcaacgac gtgacgcagg ccaacggcgg gggtgcctct     1320

gacgatatgg agagcttctg gtttgccgag gcgctcaagt atgcgtacct gatctttgcg     1380

gaggagtcgg atgtgcaggt gcaggccaac ggcgggaaca aatttgtctt taacacggag     1440

gcgcacccct ttagcatccg ttcatcatca cgacggggcg gccaccttgc ttaa           1494


<210>  53
<211>  57
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  53
atgagattcc catccatctt cactgctgtt ttgttcgctg cttcttctgc tttggct          57


<210>  54
<211>  19
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  54

Met Arg Phe Pro Ser Ile Phe Thr Ala Val Leu Phe Ala Ala Ser Ser 
1               5                   10                  15      


Ala Leu Ala 
            


<210>  55
<211>  934
<212>  DNA
<213>  Pichia pastoris

<400>  55
aacatccaaa gacgaaaggt tgaatgaaac ctttttgcca tccgacatcc acaggtccat       60

tctcacacat aagtgccaaa cgcaacagga ggggatacac tagcagcaga ccgttgcaaa      120

cgcaggacct ccactcctct tctcctcaac acccactttt gccatcgaaa aaccagccca      180

gttattgggc ttgattggag ctcgctcatt ccaattcctt ctattaggct actaacacca      240

tgactttatt agcctgtcta tcctggcccc cctggcgagg ttcatgtttg tttatttccg      300

aatgcaacaa gctccgcatt acacccgaac atcactccag atgagggctt tctgagtgtg      360

gggtcaaata gtttcatgtt ccccaaatgg cccaaaactg acagtttaaa cgctgtcttg      420

gaacctaata tgacaaaagc gtgatctcat ccaagatgaa ctaagtttgg ttcgttgaaa      480

tgctaacggc cagttggtca aaaagaaact tccaaaagtc ggcataccgt ttgtcttgtt      540

tggtattgat tgacgaatgc tcaaaaataa tctcattaat gcttagcgca gtctctctat      600

cgcttctgaa ccccggtgca cctgtgccga aacgcaaatg gggaaacacc cgctttttgg      660

atgattatgc attgtctcca cattgtatgc ttccaagatt ctggtgggaa tactgctgat      720

agcctaacgt tcatgatcaa aatttaactg ttctaacccc tacttgacag caatatataa      780

acagaaggaa gctgccctgt cttaaacctt tttttttatc atcattatta gcttactttc      840

ataattgcga ctggttccaa ttgacaagct tttgatttta acgactttta acgacaactt      900

gagaagatca aaaaacaact aattattcga aacg                                  934


<210>  56
<211>  1792
<212>  DNA
<213>  Pichia pastoris

<400>  56
taccaattgc caaatcaggc aattgtgaga cagtggtaaa aaagatgcct gcaaagttag       60

attcacacag taagagagat cctactcata aatgaggcgc ttatttagta gctagtgata      120

gccactgcgg ttctgcttta tgctatttgt tgtatgcctt actatctttg tttggctcct      180

ttttcttgac gttttccgtt ggagggactc cctattctga gtcatgagcc gcacagatta      240

tcgcccaaaa ttgacaaaat cttctggcga aaaaagtata aaaggagaaa aaagctcacc      300

cttttccagc gtagaaagta tatatcagtc attgaagact attatttaaa taacacaatg      360

tctaaaggaa aagtttgttt ggcctactcc ggtggtttgg atacctccat catcctagct      420

tggttgttgg agcagggata cgaagtcgtt gcctttttag ccaacattgg tcaagaggaa      480

gactttgagg ctgctagaga gaaagctctg aagatcggtg ctaccaagtt tatcgtcagt      540

gacgttagga aggaatttgt tgaggaagtt ttgttcccag cagtccaagt taacgctatc      600

tacgagaacg tctacttact gggtacctct ttggccagac cagtcattgc caaggcccaa      660

atagaggttg ctgaacaaga aggttgtttt gctgttgccc acggttgtac cggaaagggt      720

aacgatcagg ttagatttga gctttccttt tatgctctga agcctgacgt tgtctgtatc      780

gccccatgga gagacccaga attcttcgaa agattcgctg gtagaaatga cttgctgaat      840

tacgctgctg agaaggatat tccagttgct cagactaaag ccaagccatg gtctactgat      900

gagaacatgg ctcacatctc cttcgaggct ggtattctag aagatccaaa cactactcct      960

ccaaaggaca tgtggaagct cactgttgac ccagaagatg caccagacaa gccagagttc     1020

tttgacgtcc actttgagaa gggtaagcca gttaaattag ttctcgagaa caaaactgag     1080

gtcaccgatc cggttgagat ctttttgact gctaacgcca ttgctagaag aaacggtgtt     1140

ggtagaattg acattgtcga gaacagattc atcggaatca agtccagagg ttgttatgaa     1200

actccaggtt tgactctact gagaaccact cacatcgact tggaaggtct taccgttgac     1260

cgtgaagtta gatcgatcag agacactttt gttaccccaa cctactctaa gttgttatac     1320

aacgggttgt actttacccc agaaggtgag tacgtcagaa ctatgattca gccttctcaa     1380

aacaccgtca acggtgttgt tagagccaag gcctacaaag gtaatgtgta taacctagga     1440

agatactctg aaaccgagaa attgtacgat gctaccgaat cttccatgga tgagttgacc     1500

ggattccacc ctcaagaagc tggaggattt atcacaacac aagccatcag aatcaagaag     1560

tacggagaaa gtgtcagaga gaagggaaag tttttgggac tttaactcaa gtaaaaggat     1620

agttgtacaa ttatatatac gaagaataaa tcattacaaa aagtattcgt ttctttgatt     1680

cttaacagga ttcattttct gggtgtcatc aggtacagcg ctgaatatct tgaagttaac     1740

atcgagctca tcatcgacgt tcatcacact agccacgttt ccgcaacggt ag             1792


<210>  57
<211>  1470
<212>  DNA
<213>  Pichia pastoris

<400>  57
gggactttaa ctcaagtaaa aggatagttg tacaattata tatacgaaga ataaatcatt       60

acaaaaagta ttcgtttctt tgattcttaa caggattcat tttctgggtg tcatcaggta      120

cagcgctgaa tatcttgaag ttaacatcga gctcatcatc gacgttcatc acactagcca      180

cgtttccgca acggtagcaa taattaggag cggaccacac agtgacgaca tctttctctt      240

tgaaatggta tctgaagcct tccatgacca attgatgggc tctagcgatg agttgcaagt      300

tattaatgtg gttgaactca cgtgctactc gagcaccgaa taaccagcca gctccacgag      360

gagaaacagc ccaactgtcg acttcatctg ggtcagacca aaccaagtca caaaatcctc      420

cttcatgagg gacctcttgc gctcggctga gaactctgat ttgatctaac atgcgaatat      480

cgggagagag accaccatgg atacataata ttttaccatc aatgatggca ctaagggtta      540

aaaagtcgaa cacctggcaa cagtacttcc agacagtggt ggaaccatat ttattgagac      600

attcctcata aaatccataa acctgagtga tctgtctgga ttcatgattt ccccttacca      660

atgtgatatg ttgaggaaac ttaattttta aaatcatgag taacgtgaac gtctccaacg      720

agaaatagcc tctatccaca tagtctccta ggaagatata gttctgtttt attccattag      780

aggaggatcc gggaaaccca ccactaatct tgaaaagttc cagtagatcg tgaaattggc      840

cgtgaatatc tccgcatact gtcactggac tctgcactgg ctgtatattg gattcctcca      900

tcagcaaatc cttcacccgt tcgcaaagat gcttcatatc attttcactt aaagccttgc      960

agcttttgac ttcttcaaac cactgatctg gtcctctttc tggcatgatt aaggtctata     1020

atatttctga gctgagatgt aaaaaaaaat aataaaaatg gggagtgaaa aagtgtgtag     1080

cttttaggag tttgggattg ataccccaaa atgatcttta tgagaattaa aaggtagata     1140

cgcttttaat aagaacacct atctatagta ctttgtggtc ttgagtaatt gagatgttca     1200

gcttctgagg tttgccgtta ttctgggata gtagtgcgcg accaaacaac ccgccaggca     1260

aagtgtgttg tgctcgaaga cgattgccag aagagtaagt ccgtcctgcc tcagatgtta     1320

cacactttct tccctagaca gtcgatgcat catcggattt aaacctgaaa ctttgatgcc     1380

atgatacgcc tagtcacgtc gactgagatt ttagataagc cccgatccct ttagtacatt     1440

cctgttatcc atggatggaa tggcctgata                                      1470


<210>  58
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  58
gaggttcagt tggttgaatc tggaggagga ttggttcaac ctggtggttc tttgagattg       60

tcctgtgctg cttccggttt caacatcaag gacacttaca tccactgggt tagacaagct      120

ccaggaaagg gattggagtg ggttgctaga atctacccaa ctaacggtta cacaagatac      180

gctgactccg ttaagggaag attcactatc tctgctgaca cttccaagaa cactgcttac      240

ttgcagatga actccttgag agctgaggat actgctgttt actactgttc cagatggggt      300

ggtgatggtt tctacgctat ggactactgg ggtcaaggaa ctttggttac tgtttcctcc      360

gcttctacta agggaccatc tgttttccca ttggctccat cttctaagtc tacttccggt      420

ggtactgctg ctttgggatg tttggttaaa gactacttcc cagagccagt tactgtttct      480

tggaactccg gtgctttgac ttctggtgtt cacactttcc cagctgtttt gcaatcttcc      540

ggtttgtact ctttgtcctc cgttgttact gttccatcct cttccttggg tactcagact      600

tacatctgta acgttaacca caagccatcc aacactaagg ttgacaagaa ggttgagcca      660

aagtcctgtg acaagacaca tacttgtcca ccatgtccag ctccagaatt gttgggtggt      720

ccatccgttt tcttgttccc accaaagcca aaggacactt tgatgatctc cagaactcca      780

gaggttacat gtgttgttgt tgacgtttct cacgaggacc cagaggttaa gttcaactgg      840

tacgttgacg gtgttgaagt tcacaacgct aagactaagc caagagaaga gcagtacaac      900

tccacttaca gagttgtttc cgttttgact gttttgcacc aggactggtt gaacggtaaa      960

gaatacaagt gtaaggtttc caacaaggct ttgccagctc caatcgaaaa gactatctcc     1020

aaggctaagg gtcaaccaag agagccacag gtttacactt tgccaccatc cagagaagag     1080

atgactaaga accaggtttc cttgacttgt ttggttaaag gattctaccc atccgacatt     1140

gctgttgagt gggaatctaa cggtcaacca gagaacaact acaagactac tccaccagtt     1200

ttggattctg atggttcctt cttcttgtac tccaagttga ctgttgacaa gtccagatgg     1260

caacagggta acgttttctc ctgttccgtt atgcatgagg ctttgcacaa ccactacact     1320

caaaagtcct tgtctttgtc ccctggttaa                                      1350


<210>  59
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  59
gacatccaaa tgactcaatc cccatcttct ttgtctgctt ccgttggtga cagagttact       60

atcacttgta gagcttccca ggacgttaat actgctgttg cttggtatca acagaagcca      120

ggaaaggctc caaagttgtt gatctactcc gcttccttct tgtactctgg tgttccatcc      180

agattctctg gttccagatc cggtactgac ttcactttga ctatctcctc cttgcaacca      240

gaagatttcg ctacttacta ctgtcagcag cactacacta ctccaccaac tttcggacag      300

ggtactaagg ttgagatcaa gagaactgtt gctgctccat ccgttttcat tttcccacca      360

tccgacgaac agttgaagtc tggtacagct tccgttgttt gtttgttgaa caacttctac      420

ccaagagagg ctaaggttca gtggaaggtt gacaacgctt tgcaatccgg taactcccaa      480

gaatccgtta ctgagcaaga ctctaaggac tccacttact ccttgtcctc cactttgact      540

ttgtccaagg ctgattacga gaagcacaag gtttacgctt gtgaggttac acatcagggt      600

ttgtcctccc cagttactaa gtccttcaac agaggagagt gttaa                      645


<210>  60
<211>  375
<212>  DNA
<213>  Streptoalloteichus hindustanus

<400>  60
atggccaagt tgaccagtgc cgttccggtg ctcaccgcgc gcgacgtcgc cggagcggtc       60

gagttctgga ccgaccggct cgggttctcc cgggacttcg tggaggacga cttcgccggt      120

gtggtccggg acgacgtgac cctgttcatc agcgcggtcc aggaccaggt ggtgccggac      180

aacaccctgg cctgggtgtg ggtgcgcggc ctggacgagc tgtacgccga gtggtcggag      240

gtcgtgtcca cgaacttccg ggacgcctcc gggccggcca tgaccgagat cggcgagcag      300

ccgtgggggc gggagttcgc cctgcgcgac ccggccggca actgcgtgca cttcgtggcc      360

gaggagcagg actga                                                       375


<210>  61
<211>  427
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  61
gatcccccac acaccatagc ttcaaaatgt ttctactcct tttttactct tccagatttt       60

ctcggactcc gcgcatcgcc gtaccacttc aaaacaccca agcacagcat actaaatttc      120

ccctctttct tcctctaggg tgtcgttaat tacccgtact aaaggtttgg aaaagaaaaa      180

agagaccgcc tcgtttcttt ttcttcgtcg aaaaaggcaa taaaaatttt tatcacgttt      240

ctttttcttg aaaatttttt tttttgattt ttttctcttt cgatgacctc ccattgatat      300

ttaagttaat aaacggtctt caatttctca agtttcagtt tcatttttct tgttctatta      360

caactttttt tacttcttgc tcattagaaa gaaagcatag caatctaatc taagttttaa      420

ttacaaa                                                                427


<210>  62
<211>  1617
<212>  DNA
<213>  Pichia pastoris

<400>  62
atgagtgtaa gtgatagtca tcttgcaaca gattattttg gaacgcaact aacaaagcag       60

atacaccctt cagcagaatc ctttctggat attgtgaaga atgatcgcca aagtcacagt      120

cctgagacag ttcctaatct ttaccccatt tacaagttca tccaatcaga cttcttaacg      180

cctcatctgg cttatatcaa gcttaccaac agttcagaaa ctcccagtcc aagtttcttg      240

cttgaaagtg cgaagaatgg tgacaccgtt gacaggtaca cctttatggg acattccccc      300

agaaaaataa tcaagactgg gcctttagag ggtgctgaag ttgacccctt ggtgcttctg      360

gaaaaagaac tgaagggcac cagacaagcg caacttcctg gtattcctcg tctaagtggt      420

ggtgccatag gatacatctc gtacgattgt attaagtact ttgaaccaaa aactgaaaga      480

aaactgaaag atgttttgca acttccggaa gcagctttga tgttgttcga cacgatcgtg      540

gcttttgaca atgtttatca aagattccag gtaattggaa acgtttctct atccgttgat      600

gactcggacg aagctattct tgagaaatat tataagacaa gagaagaagt ggaaaagatc      660

agtaaagtgg tatttgacaa taaaactgtt ccctactatg aacagaaaga tattattcaa      720

ggccaaacgt tcacctctaa tattggtcag gaagggtatg aaaaccatgt tcgcaagctg      780

aaagaacata ttctgaaagg agacatcttc caagctgttc cctctcaaag ggtagccagg      840

ccgacctcat tgcacccttt caacatctat cgtcatttga gaactgtcaa tccttctcca      900

tacatgttct atattgacta tctagacttc caagttgttg gtgcttcacc tgaattacta      960

gttaaatccg acaacaacaa caaaatcatc acacatccta ttgctggaac tcttcccaga     1020

ggtaaaacta tcgaagagga cgacaattat gctaagcaat tgaagtcgtc tttgaaagac     1080

agggccgagc acgtcatgct ggtagatttg gccagaaatg atattaaccg tgtgtgtgag     1140

cccaccagta ccacggttga tcgtttattg actgtggaga gattttctca tgtgatgcat     1200

cttgtgtcag aagtcagtgg aacattgaga ccaaacaaga ctcgcttcga tgctttcaga     1260

tccattttcc cagcaggaac cgtctccggt gctccgaagg taagagcaat gcaactcata     1320

ggagaattgg aaggagaaaa gagaggtgtt tatgcggggg ccgtaggaca ctggtcgtac     1380

gatggaaaat cgatggacac atgtattgcc ttaagaacaa tggtcgtcaa ggacggtgtc     1440

gcttaccttc aagccggagg tggaattgtc tacgattctg acccctatga cgagtacatc     1500

gaaaccatga acaaaatgag atccaacaat aacaccatct tggaggctga gaaaatctgg     1560

accgataggt tggccagaga cgagaatcaa agtgaatccg aagaaaacga tcaatga        1617


<210>  63
<211>  414
<212>  DNA
<213>  Pichia pastoris

<400>  63
ccggccattt aaatatgtga cgactgggtg atccgggtta gtgagttgtt ctcccatctg       60

tatatttttc atttacgatg aatacgaaat gagtattaag aaatcaggcg tagcaatatg      120

ggcagtgttc agtcctgtca tagatggcaa gcactggcac atccttaata ggttagagaa      180

aatcattgaa tcatttgggt ggtgaaaaaa aattgatgta aacaagccac ccacgctggg      240

agtcgaaccc agaatctttt gattagaagt caaacgcgtt aaccattacg ctacgcaggc      300

atgtttcacg tccatttttg attgctttct atcataatct aaagatgtga actcaattag      360

ttgcaatttg accaattctt ccattacaag tcgtgcttcc tccgttgatg caac            414


<210>  64
<211>  582
<212>  DNA
<213>  Streptomyces noursei

<400>  64
atgggtacca ctcttgacga cacggcttac cggtaccgca ccagtgtccc gggggacgcc       60

gaggccatcg aggcactgga tgggtccttc accaccgaca ccgtcttccg cgtcaccgcc      120

accggggacg gcttcaccct gcgggaggtg ccggtggacc cgcccctgac caaggtgttc      180

cccgacgacg aatcggacga cgaatcggac gacggggagg acggcgaccc ggactcccgg      240

acgttcgtcg cgtacgggga cgacggcgac ctggcgggct tcgtggtcgt ctcgtactcc      300

ggctggaacc gccggctgac cgtcgaggac atcgaggtcg ccccggagca ccgggggcac      360

ggggtcgggc gcgcgttgat ggggctcgcg acggagttcg cccgcgagcg gggcgccggg      420

cacctctggc tggaggtcac caacgtcaac gcaccggcga tccacgcgta ccggcggatg      480

gggttcaccc tctgcggcct ggacaccgcc ctgtacgacg gcaccgcctc ggacggcgag      540

caggcgctct acatgagcat gccctgcccc taatcagtac tg                         582


<210>  65
<211>  388
<212>  DNA
<213>  Ashbya gossypii

<400>  65
gatctgttta gcttgcctcg tccccgccgg gtcacccggc cagcgacatg gaggcccaga       60

ataccctcct tgacagtctt gacgtgcgca gctcaggggc atgatgtgac tgtcgcccgt      120

acatttagcc catacatccc catgtataat catttgcatc catacatttt gatggccgca      180

cggcgcgaag caaaaattac ggctcctcgc tgcagacctg cgagcaggga aacgctcccc      240

tcacagacgc gttgaattgt ccccacgccg cgcccctgta gagaaatata aaaggttagg      300

atttgccact gaggttcttc tttcatatac ttccttttaa aatcttgcta ggatacagtt      360

ctcacatcac atccgaacat aaacaacc                                         388


<210>  66
<211>  247
<212>  DNA
<213>  Ashbya gossypii

<400>  66
taatcagtac tgacaataaa aagattcttg ttttcaagaa cttgtcattt gtatagtttt       60

tttatattgt agttgttcta ttttaatcaa atgttagcgt gatttatatt ttttttcgcc      120

tcgacatcat ctgcccagat gcgaagttaa gtgcgcagaa agtaatatca tgcgtcaatc      180

gtatgtgaat gctggtcgct atactgctgt cgattcgata ctaacgccgc catccagtgt      240

cgaaaac                                                                247


<210>  67
<211>  672
<212>  DNA
<213>  Pichia pastoris

<400>  67
gcggaaacgg cagtaaacaa tggagcttca ttagtgggtg ttattatggt ccctggccgg       60

gaacgaacgg tgaaacaaga ggttgcgagg gaaatttcgc agatggtgcg ggaaaagaga      120

atttcaaagg gctcaaaata cttggattcc agacaactga ggaaagagtg ggacgactgt      180

cctctggaag actggtttga gtacaacgtg aaagaaataa acagcagtgg tccattttta      240

gttggagttt ttcgtaatca aagtatagat gaaatccagc aagctatcca cactcatggt      300

ttggatttcg tccaactaca tgggtctgag gattttgatt cgtatatacg caatatccca      360

gttcctgtga ttaccagata cacagataat gccgtcgatg gtcttaccgg agaagacctc      420

gctataaata gggccctggt gctactggac agcgagcaag gaggtgaagg aaaaaccatc      480

gattgggctc gtgcacaaaa atttggagaa cgtagaggaa aatatttact agccggaggt      540

ttgacacctg ataatgttgc tcatgctcga tctcatactg gctgtattgg tgttgacgtc      600

tctggtgggg tagaaacaaa tgcctcaaaa gatatggaca agatcacaca atttatcaga      660

aacgctacat aa                                                          672


<210>  68
<211>  834
<212>  DNA
<213>  Pichia pastoris

<400>  68
aagtcaatta aatacacgct tgaaaggaca ttacatagct ttcgatttaa gcagaaccag       60

aaatgtagaa ccacttgtca atagattggt caatcttagc aggagcggct gggctagcag      120

ttggaacagc agaggttgct gaaggtgaga aggatggagt ggattgcaaa gtggtgttgg      180

ttaagtcaat ctcaccaggg ctggttttgc caaaaatcaa cttctcccag gcttcacggc      240

attcttgaat gacctcttct gcatacttct tgttcttgca ttcaccagag aaagcaaact      300

ggttctcagg ttttccatca gggatcttgt aaattctgaa ccattcgttg gtagctctca      360

acaagcccgg catgtgcttt tcaacatcct cgatgtcatt gagcttagga gccaatgggt      420

cgttgatgtc gatgacgatg accttccagt cagtctctcc ctcatccaac aaagccataa      480

caccgaggac cttgacttgc ttgacctgtc cagtgtaacc tacggcttca ccaatttcgc      540

aaacgtccaa tggatcattg tcacccttgg ccttggtctc tggatgagtg acgttagggt      600

cttcccatgt ctgagggaag gcaccgtagt tgtgaatgta tccgtggtga gggaaacagt      660

tacgaacgaa acgaagtttt cccttctttg tgtcctgaag aattgggttc agtttctcct      720

ccttggaaat ctccaacttg gcgttggtcc aacgggggac ttcaacaacc atgttgagaa      780

ccttcttgga ttcgtcagca taaagtggga tgtcgtggaa aggagatacg actt            834


<210>  69
<211>  29
<212>  DNA
<213>  Pichia pastoris

<400>  69
gttaaatgac tctaacacct tgcacttga                                         29


<210>  70
<211>  27
<212>  DNA
<213>  Pichia pastoris

<400>  70
cctcccactg gaaccgatga tatggaa                                           27


<210>  71
<211>  33
<212>  DNA
<213>  Pichia pastoris

<400>  71
gatgcgaagt taagtgcgca gaaagtaata tca                                    33


<210>  72
<211>  24
<212>  DNA
<213>  Pichia pastoris

<400>  72
ttgcaaaaac cagtgaggaa tagc                                              24


<210>  73
<211>  26
<212>  DNA
<213>  Pichia pastoris

<400>  73
gaatgctgaa gaacgtcaaa gaaact                                            26


<210>  74
<211>  25
<212>  DNA
<213>  Pichia pastoris

<400>  74
tgagacttca gagctttcca tacga                                             25


<210>  75
<211>  4356
<212>  DNA
<213>  Pichia pastoris

<400>  75
atgggtattc caaagttttt tcggtacatc tctgagagat ggccgatgat atctgagcca       60

atagaagaca gccaaattgc cgagtttgat aacctgtatc tggacatgaa ctcaattctt      120

cataattgta cacatagtaa cgatggatca gttgatttaa tgaaagaaga agagatgttc      180

agtgctattt ttgcttacat tgaacatctt ttcactttga tcaaacctgg aaagacgttt      240

ttcatggcca ttgatggtgt tgctcctaga gcaaagatga accagcaacg atctagaaga      300

ttcaggacgg ccattgaggc agaaaaaagt gtagagatag cccaaaagaa tggactcatt      360

actagcaaag acgagaattt tgacagtaac tgtatcactc ctggaacgga gtttatggcc      420

aaggttacca ctaacttgaa gtttttcatc caccagaaaa tctcttcaga tgcaaaatgg      480

cagaaagtcc aggttattct cagtggacat gaagtccccg gagaaggaga gcacaaaatt      540

atggactata ttcgtttttt gaaggctcaa gaggggtatg atccgaatac gagacattgt      600

atttacgggc tggatgcaga cttgatcatg ttgggattgg tcattcacga tcctcatttt      660

gccatcttga gagaagaggt tgtgttcgga agaggatcca aggcctcgtc aacagatgtg      720

tcagaacagc aattctacct tctacatctc tccttgttac gtgaatacct tgctcttgag      780

ttcaaagatt tagaagacca gataaagttt gattatgact tagagagaat cttggacgat      840

tttattttta tcatgtatgt tattggaaat gatttcttac ccaacttacc tgacttgcat      900

atcaacaaag gtgccttccc cagactctta gcaacgatca aagaaaccat gatagattcg      960

gatggatatc tccaagaagg aggtgtcatc aatatggaac gattcggtct gtggcttgac     1020

cacttgtcac aatttgagct tcaaaatttt gagcaggtcg acgtggatgt agaatggttt     1080

aacaagcagc tagagaacat atccctagat ggtgagcgaa agagggaaag agctggaaga     1140

aagttgttgc ttagacgtca acaggaatta atttcaaaac ttagaccatg gattctcgag     1200

ttttattcat caagagacaa tatatattct gctcatgatg atgactcctt aattccaact     1260

ttgcaattgg acaccgaatt gatggaagaa gaaatcaagt tacccttcat aaagcagttt     1320

gcacttgatg ttggtttctt tattgtgcac agcaaatctc agaatacgta ccatgctaag     1380

atagacattg atggtataaa tgtcaatgaa tctgatgaag aatttgaagc tcgtgtcttg     1440

tatatcagga agaagatcaa agaatatgaa aactcaattt ttgttgaaga tgaaaacact     1500

ttagaggaac aaaagaacat ttatgatacc aagttcgtca actggaaaaa caaatattac     1560

aaagaaaagt ttggatttac tctttctgac acagaggaca ttttgaagtt gacggagtcg     1620

tatattcagg gtcttcaatg ggttttgttc tactattatc gaggagttcc ttcttggcaa     1680

tggtactatc cttattacta tgctcctaga atctctgaca tcaaattagg gattaaggct     1740

tgcctggagt ttgacaaagg tacaccgttc aagccatttg aacaattaat ggctgtcctt     1800

cctgcaagat caaaacagtt agttcctgct tgttatagac cgttgatgac cgatccaaac     1860

tctcccatta ttgaatttta ccctgatgag gttgaaattg acaagaatgg aaagactgcc     1920

tcttgggagg ctgttgttaa aatcaacttt gtcgatgaaa aacgactatt agaggcactg     1980

gaaccgtata atagtaagtt gaatgctgaa gaacgtcaaa gaaactcttt gggcacgaat     2040

atcgagttta gctatcatcc tcaagtgaat caagttcatt cttccccaat tccaacaata     2100

ttcccagata tcactgagga tcactgctac gaaatagtgg tcgaatttga caagctgcac     2160

tcttcaactt atgctaaacc tatgaaaggt gccaaacaag gtataaatct attggctgga     2220

ttcccaactt tgaagaccat tcccttcact tcgcagctca tgttagcgga atgccatatt     2280

tttaaccagc caacaaaatc ggaatcgatg attctaagta cacagaatcc gtttgaagga     2340

ctcactgtag agcagtttgc tgctcagaat ttgggccaaa caatctatgt caactggcct     2400

tatttgaaag aggccaaagt tgttgcagtt tctgacggtt tgaacgtttt tgagcctgga     2460

aacaagtcta tccgaacgac tcgtatggaa agctctgaag tctcagaatt tgccagtgac     2520

gttcgctata tcagtgagac gctattcaag agaaaaggtg ttttactggt gaactacact     2580

gaggaagagt tgcaaggaac acctgagcct cgtagatccc ctcacaatga cgatgcgatc     2640

caaggaattg tgtttgtaaa gaaagtgaat ggtgttattc gcactagatc gggtgcctat     2700

gtgaagacat acagtgacaa gattgagaaa taccctatta atttgcttgt tgacgacgtg     2760

gttaacaagg atcgtcgatt attagaaaaa cctcctgtgc cattagaaga agaattccca     2820

aagggtacta ctctcataag tttgggagct tttgcttacg gaactcctgc tactgttgtt     2880

gaccaccaaa atgacttaat gaccgtcaga ttcgtaaacc agccaattaa gcatgaattt     2940

aactatggtg agattcaagc acaaagggag gcacacacca atgtgtatta tccctccttt     3000

aaagttgcca aaatcgttgg aattacggcg ctagccttgt ccagaataac ctcttcctat     3060

agaatagtta atggagctaa gaaaactgtt aacatcggat tagatttgaa gtttgaagga     3120

agaaagttaa aggttctggg atacactaaa agaaacgaga aacattggtc atacagcgct     3180

ttggctgtaa acttgctgca acaatatcag aaacgtttcc catctgtttt taagataatt     3240

tctctccgaa atgattcttc aattcctgaa gccaaagaac tgtttcctca agtccccgct     3300

agccaagtgg atgaaaaagt caatgaactt gtggcttggg ttaaagaaca aaagaaaagc     3360

tttgttgttg caacattgga gtctgagtct ttgaccaagg ttagtatcgg aaagattgaa     3420

caggaagtga ttaagtttgt ttcaaaacca catgaacata ttccccaaaa gggtttgaaa     3480

ggagttcctc gtgaggctac tctggatatc agcaactctt ctcaatttct ttccaagcag     3540

acttttaatc taggagacag agtgatctac gtagaagatt ctggtaaggt acccaacttc     3600

agtaaaggta cagttattgg ggttcgaagt gtcggtacga aagtgacttt gaacgtattg     3660

tttgacttgc cattgctctc tggtaatacc tttgatggaa gacttgcaac ccccaggggt     3720

gtcactgttg atagttcatt ggtattgaac ttaacaaagc gtcaattgat ttaccacgat     3780

aggaaacccg ctaagaaaga aggtaagcct ggagttaaga agacatctca ggactccaaa     3840

aagcaaacag tgaagttgca gaacggttca ggtaaggcca aacaggcaca agatgctgaa     3900

ctgtcagtca ctacgacacc tgttccggtt cctgccgcta acactgcacc agttactgca     3960

tctgtacagg ctacctcggt ggttactgct accgttccaa cttctaaacc ttcaaacaac     4020

tctgaggacg aacatgaatt acttcgctta ctgaaaggta acaaggacag tagtgaatcg     4080

caaggctctc aagagcctct tgcccggact tctatccagc aaatttacgg aacggtgttc     4140

aatcaagtgt tgagcgctca acctcagttg cagcctgtca gaggcttctc aaatccggta     4200

cctgaaaccc ctgtaaatgg agtccaagcg aatgaacaac actctgattc tacccctcaa     4260

aatcattcta gggatgaaaa ccaaggaaga ggtcgtggta gaggcagagg aaatagaaga     4320

ggaagaggtc gaggtagagg caaaggagga cagtaa                               4356


<210>  76
<211>  1451
<212>  PRT
<213>  Pichia pastoris

<400>  76

Met Gly Ile Pro Lys Phe Phe Arg Tyr Ile Ser Glu Arg Trp Pro Met 
1               5                   10                  15      


Ile Ser Glu Pro Ile Glu Asp Ser Gln Ile Ala Glu Phe Asp Asn Leu 
            20                  25                  30          


Tyr Leu Asp Met Asn Ser Ile Leu His Asn Cys Thr His Ser Asn Asp 
        35                  40                  45              


Gly Ser Val Asp Leu Met Lys Glu Glu Glu Met Phe Ser Ala Ile Phe 
    50                  55                  60                  


Ala Tyr Ile Glu His Leu Phe Thr Leu Ile Lys Pro Gly Lys Thr Phe 
65                  70                  75                  80  


Phe Met Ala Ile Asp Gly Val Ala Pro Arg Ala Lys Met Asn Gln Gln 
                85                  90                  95      


Arg Ser Arg Arg Phe Arg Thr Ala Ile Glu Ala Glu Lys Ser Val Glu 
            100                 105                 110         


Ile Ala Gln Lys Asn Gly Leu Ile Thr Ser Lys Asp Glu Asn Phe Asp 
        115                 120                 125             


Ser Asn Cys Ile Thr Pro Gly Thr Glu Phe Met Ala Lys Val Thr Thr 
    130                 135                 140                 


Asn Leu Lys Phe Phe Ile His Gln Lys Ile Ser Ser Asp Ala Lys Trp 
145                 150                 155                 160 


Gln Lys Val Gln Val Ile Leu Ser Gly His Glu Val Pro Gly Glu Gly 
                165                 170                 175     


Glu His Lys Ile Met Asp Tyr Ile Arg Phe Leu Lys Ala Gln Glu Gly 
            180                 185                 190         


Tyr Asp Pro Asn Thr Arg His Cys Ile Tyr Gly Leu Asp Ala Asp Leu 
        195                 200                 205             


Ile Met Leu Gly Leu Val Ile His Asp Pro His Phe Ala Ile Leu Arg 
    210                 215                 220                 


Glu Glu Val Val Phe Gly Arg Gly Ser Lys Ala Ser Ser Thr Asp Val 
225                 230                 235                 240 


Ser Glu Gln Gln Phe Tyr Leu Leu His Leu Ser Leu Leu Arg Glu Tyr 
                245                 250                 255     


Leu Ala Leu Glu Phe Lys Asp Leu Glu Asp Gln Ile Lys Phe Asp Tyr 
            260                 265                 270         


Asp Leu Glu Arg Ile Leu Asp Asp Phe Ile Phe Ile Met Tyr Val Ile 
        275                 280                 285             


Gly Asn Asp Phe Leu Pro Asn Leu Pro Asp Leu His Ile Asn Lys Gly 
    290                 295                 300                 


Ala Phe Pro Arg Leu Leu Ala Thr Ile Lys Glu Thr Met Ile Asp Ser 
305                 310                 315                 320 


Asp Gly Tyr Leu Gln Glu Gly Gly Val Ile Asn Met Glu Arg Phe Gly 
                325                 330                 335     


Leu Trp Leu Asp His Leu Ser Gln Phe Glu Leu Gln Asn Phe Glu Gln 
            340                 345                 350         


Val Asp Val Asp Val Glu Trp Phe Asn Lys Gln Leu Glu Asn Ile Ser 
        355                 360                 365             


Leu Asp Gly Glu Arg Lys Arg Glu Arg Ala Gly Arg Lys Leu Leu Leu 
    370                 375                 380                 


Arg Arg Gln Gln Glu Leu Ile Ser Lys Leu Arg Pro Trp Ile Leu Glu 
385                 390                 395                 400 


Phe Tyr Ser Ser Arg Asp Asn Ile Tyr Ser Ala His Asp Asp Asp Ser 
                405                 410                 415     


Leu Ile Pro Thr Leu Gln Leu Asp Thr Glu Leu Met Glu Glu Glu Ile 
            420                 425                 430         


Lys Leu Pro Phe Ile Lys Gln Phe Ala Leu Asp Val Gly Phe Phe Ile 
        435                 440                 445             


Val His Ser Lys Ser Gln Asn Thr Tyr His Ala Lys Ile Asp Ile Asp 
    450                 455                 460                 


Gly Ile Asn Val Asn Glu Ser Asp Glu Glu Phe Glu Ala Arg Val Leu 
465                 470                 475                 480 


Tyr Ile Arg Lys Lys Ile Lys Glu Tyr Glu Asn Ser Ile Phe Val Glu 
                485                 490                 495     


Asp Glu Asn Thr Leu Glu Glu Gln Lys Asn Ile Tyr Asp Thr Lys Phe 
            500                 505                 510         


Val Asn Trp Lys Asn Lys Tyr Tyr Lys Glu Lys Phe Gly Phe Thr Leu 
        515                 520                 525             


Ser Asp Thr Glu Asp Ile Leu Lys Leu Thr Glu Ser Tyr Ile Gln Gly 
    530                 535                 540                 


Leu Gln Trp Val Leu Phe Tyr Tyr Tyr Arg Gly Val Pro Ser Trp Gln 
545                 550                 555                 560 


Trp Tyr Tyr Pro Tyr Tyr Tyr Ala Pro Arg Ile Ser Asp Ile Lys Leu 
                565                 570                 575     


Gly Ile Lys Ala Cys Leu Glu Phe Asp Lys Gly Thr Pro Phe Lys Pro 
            580                 585                 590         


Phe Glu Gln Leu Met Ala Val Leu Pro Ala Arg Ser Lys Gln Leu Val 
        595                 600                 605             


Pro Ala Cys Tyr Arg Pro Leu Met Thr Asp Pro Asn Ser Pro Ile Ile 
    610                 615                 620                 


Glu Phe Tyr Pro Asp Glu Val Glu Ile Asp Lys Asn Gly Lys Thr Ala 
625                 630                 635                 640 


Ser Trp Glu Ala Val Val Lys Ile Asn Phe Val Asp Glu Lys Arg Leu 
                645                 650                 655     


Leu Glu Ala Leu Glu Pro Tyr Asn Ser Lys Leu Asn Ala Glu Glu Arg 
            660                 665                 670         


Gln Arg Asn Ser Leu Gly Thr Asn Ile Glu Phe Ser Tyr His Pro Gln 
        675                 680                 685             


Val Asn Gln Val His Ser Ser Pro Ile Pro Thr Ile Phe Pro Asp Ile 
    690                 695                 700                 


Thr Glu Asp His Cys Tyr Glu Ile Val Val Glu Phe Asp Lys Leu His 
705                 710                 715                 720 


Ser Ser Thr Tyr Ala Lys Pro Met Lys Gly Ala Lys Gln Gly Ile Asn 
                725                 730                 735     


Leu Leu Ala Gly Phe Pro Thr Leu Lys Thr Ile Pro Phe Thr Ser Gln 
            740                 745                 750         


Leu Met Leu Ala Glu Cys His Ile Phe Asn Gln Pro Thr Lys Ser Glu 
        755                 760                 765             


Ser Met Ile Leu Ser Thr Gln Asn Pro Phe Glu Gly Leu Thr Val Glu 
    770                 775                 780                 


Gln Phe Ala Ala Gln Asn Leu Gly Gln Thr Ile Tyr Val Asn Trp Pro 
785                 790                 795                 800 


Tyr Leu Lys Glu Ala Lys Val Val Ala Val Ser Asp Gly Leu Asn Val 
                805                 810                 815     


Phe Glu Pro Gly Asn Lys Ser Ile Arg Thr Thr Arg Met Glu Ser Ser 
            820                 825                 830         


Glu Val Ser Glu Phe Ala Ser Asp Val Arg Tyr Ile Ser Glu Thr Leu 
        835                 840                 845             


Phe Lys Arg Lys Gly Val Leu Leu Val Asn Tyr Thr Glu Glu Glu Leu 
    850                 855                 860                 


Gln Gly Thr Pro Glu Pro Arg Arg Ser Pro His Asn Asp Asp Ala Ile 
865                 870                 875                 880 


Gln Gly Ile Val Phe Val Lys Lys Val Asn Gly Val Ile Arg Thr Arg 
                885                 890                 895     


Ser Gly Ala Tyr Val Lys Thr Tyr Ser Asp Lys Ile Glu Lys Tyr Pro 
            900                 905                 910         


Ile Asn Leu Leu Val Asp Asp Val Val Asn Lys Asp Arg Arg Leu Leu 
        915                 920                 925             


Glu Lys Pro Pro Val Pro Leu Glu Glu Glu Phe Pro Lys Gly Thr Thr 
    930                 935                 940                 


Leu Ile Ser Leu Gly Ala Phe Ala Tyr Gly Thr Pro Ala Thr Val Val 
945                 950                 955                 960 


Asp His Gln Asn Asp Leu Met Thr Val Arg Phe Val Asn Gln Pro Ile 
                965                 970                 975     


Lys His Glu Phe Asn Tyr Gly Glu Ile Gln Ala Gln Arg Glu Ala His 
            980                 985                 990         


Thr Asn Val Tyr Tyr Pro Ser Phe  Lys Val Ala Lys Ile  Val Gly Ile 
        995                 1000                 1005             


Thr Ala  Leu Ala Leu Ser Arg  Ile Thr Ser Ser Tyr  Arg Ile Val 
    1010                 1015                 1020             


Asn Gly  Ala Lys Lys Thr Val  Asn Ile Gly Leu Asp  Leu Lys Phe 
    1025                 1030                 1035             


Glu Gly  Arg Lys Leu Lys Val  Leu Gly Tyr Thr Lys  Arg Asn Glu 
    1040                 1045                 1050             


Lys His  Trp Ser Tyr Ser Ala  Leu Ala Val Asn Leu  Leu Gln Gln 
    1055                 1060                 1065             


Tyr Gln  Lys Arg Phe Pro Ser  Val Phe Lys Ile Ile  Ser Leu Arg 
    1070                 1075                 1080             


Asn Asp  Ser Ser Ile Pro Glu  Ala Lys Glu Leu Phe  Pro Gln Val 
    1085                 1090                 1095             


Pro Ala  Ser Gln Val Asp Glu  Lys Val Asn Glu Leu  Val Ala Trp 
    1100                 1105                 1110             


Val Lys  Glu Gln Lys Lys Ser  Phe Val Val Ala Thr  Leu Glu Ser 
    1115                 1120                 1125             


Glu Ser  Leu Thr Lys Val Ser  Ile Gly Lys Ile Glu  Gln Glu Val 
    1130                 1135                 1140             


Ile Lys  Phe Val Ser Lys Pro  His Glu His Ile Pro  Gln Lys Gly 
    1145                 1150                 1155             


Leu Lys  Gly Val Pro Arg Glu  Ala Thr Leu Asp Ile  Ser Asn Ser 
    1160                 1165                 1170             


Ser Gln  Phe Leu Ser Lys Gln  Thr Phe Asn Leu Gly  Asp Arg Val 
    1175                 1180                 1185             


Ile Tyr  Val Glu Asp Ser Gly  Lys Val Pro Asn Phe  Ser Lys Gly 
    1190                 1195                 1200             


Thr Val  Ile Gly Val Arg Ser  Val Gly Thr Lys Val  Thr Leu Asn 
    1205                 1210                 1215             


Val Leu  Phe Asp Leu Pro Leu  Leu Ser Gly Asn Thr  Phe Asp Gly 
    1220                 1225                 1230             


Arg Leu  Ala Thr Pro Arg Gly  Val Thr Val Asp Ser  Ser Leu Val 
    1235                 1240                 1245             


Leu Asn  Leu Thr Lys Arg Gln  Leu Ile Tyr His Asp  Arg Lys Pro 
    1250                 1255                 1260             


Ala Lys  Lys Glu Gly Lys Pro  Gly Val Lys Lys Thr  Ser Gln Asp 
    1265                 1270                 1275             


Ser Lys  Lys Gln Thr Val Lys  Leu Gln Asn Gly Ser  Gly Lys Ala 
    1280                 1285                 1290             


Lys Gln  Ala Gln Asp Ala Glu  Leu Ser Val Thr Thr  Thr Pro Val 
    1295                 1300                 1305             


Pro Val  Pro Ala Ala Asn Thr  Ala Pro Val Thr Ala  Ser Val Gln 
    1310                 1315                 1320             


Ala Thr  Ser Val Val Thr Ala  Thr Val Pro Thr Ser  Lys Pro Ser 
    1325                 1330                 1335             


Asn Asn  Ser Glu Asp Glu His  Glu Leu Leu Arg Leu  Leu Lys Gly 
    1340                 1345                 1350             


Asn Lys  Asp Ser Ser Glu Ser  Gln Gly Ser Gln Glu  Pro Leu Ala 
    1355                 1360                 1365             


Arg Thr  Ser Ile Gln Gln Ile  Tyr Gly Thr Val Phe  Asn Gln Val 
    1370                 1375                 1380             


Leu Ser  Ala Gln Pro Gln Leu  Gln Pro Val Arg Gly  Phe Ser Asn 
    1385                 1390                 1395             


Pro Val  Pro Glu Thr Pro Val  Asn Gly Val Gln Ala  Asn Glu Gln 
    1400                 1405                 1410             


His Ser  Asp Ser Thr Pro Gln  Asn His Ser Arg Asp  Glu Asn Gln 
    1415                 1420                 1425             


Gly Arg  Gly Arg Gly Arg Gly  Arg Gly Asn Arg Arg  Gly Arg Gly 
    1430                 1435                 1440             


Arg Gly  Arg Gly Lys Gly Gly  Gln 
    1445                 1450     


<210>  77
<211>  1014
<212>  DNA
<213>  Mus

<400>  77
atggctccag ctagagaaaa cgtttccttg ttcttcaagt tgtactgttt ggctgttatg       60

actttggttg ctgctgctta cactgttgct ttgagataca ctagaactac tgctgaggag      120

ttgtacttct ccactactgc tgtttgtatc actgaggtta tcaagttgtt gatctccgtt      180

ggtttgttgg ctaaggagac tggttctttg ggaagattca aggcttcctt gtccgaaaac      240

gttttgggtt ccccaaagga gttggctaag ttgtctgttc catccttggt ttacgctgtt      300

cagaacaaca tggctttctt ggctttgtct aacttggacg ctgctgttta ccaagttact      360

taccagttga agatcccatg tactgctttg tgtactgttt tgatgttgaa cagaacattg      420

tccaagttgc agtggatctc cgttttcatg ttgtgtggtg gtgttacttt ggttcagtgg      480

aagccagctc aagcttccaa agttgttgtt gctcagaacc cattgttggg tttcggtgct      540

attgctatcg ctgttttgtg ttccggtttc gctggtgttt acttcgagaa ggttttgaag      600

tcctccgaca cttctttgtg ggttagaaac atccagatgt acttgtccgg tatcgttgtt      660

actttggctg gtacttactt gtctgacggt gctgagattc aagagaaggg attcttctac      720

ggttacactt actatgtttg gttcgttatc ttcttggctt ccgttggtgg tttgtacact      780

tccgttgttg ttaagtacac tgacaacatc atgaagggat tctctgctgc tgctgctatt      840

gttttgtcca ctatcgcttc cgttttgttg ttcggattgc agatcacatt gtcctttgct      900

ttgggagctt tgttggtttg tgtttccatc tacttgtacg gattgccaag acaagacact      960

acttccattc agcaagaggc tacttccaag gagagaatca tcggtgttta gtag           1014


<210>  78
<211>  2172
<212>  DNA
<213>  Homo sapiens

<400>  78
atggaaaaga acggtaacaa cagaaagttg agagtttgtg ttgctacttg taacagagct       60

gactactcca agttggctcc aatcatgttc ggtatcaaga ctgagccaga gttcttcgag      120

ttggacgttg ttgttttggg ttcccacttg attgatgact acggtaacac ttacagaatg      180

atcgagcagg acgacttcga catcaacact agattgcaca ctattgttag aggagaggac      240

gaagctgcta tggttgaatc tgttggattg gctttggtta agttgccaga cgttttgaac      300

agattgaagc cagacatcat gattgttcac ggtgacagat tcgatgcttt ggctttggct      360

acttccgctg ctttgatgaa cattagaatc ttgcacatcg agggtggtga agtttctggt      420

actatcgacg actccatcag acacgctatc actaagttgg ctcactacca tgtttgttgt      480

actagatccg ctgagcaaca cttgatttcc atgtgtgagg accacgacag aattttgttg      540

gctggttgtc catcttacga caagttgttg tccgctaaga acaaggacta catgtccatc      600

atcagaatgt ggttgggtga cgacgttaag tctaaggact acatcgttgc tttgcagcac      660

ccagttacta ctgacatcaa gcactccatc aagatgttcg agttgacttt ggacgctttg      720

atctccttca acaagagaac tttggttttg ttcccaaaca ttgacgctgg ttccaaagag      780

atggttagag ttatgagaaa gaagggtatc gaacaccacc caaacttcag agctgttaag      840

cacgttccat tcgaccaatt catccagttg gttgctcatg ctggttgtat gatcggtaac      900

tcctcctgtg gtgttagaga agttggtgct ttcggtactc cagttatcaa cttgggtact      960

agacagatcg gtagagagac tggagaaaac gttttgcatg ttagagatgc tgacactcag     1020

gacaagattt tgcaggcttt gcacttgcaa ttcggaaagc agtacccatg ttccaaaatc     1080

tacggtgacg gtaacgctgt tccaagaatc ttgaagtttt tgaagtccat cgacttgcaa     1140

gagccattgc agaagaagtt ctgtttccca ccagttaagg agaacatctc ccaggacatt     1200

gaccacatct tggagacatt gtccgctttg gctgttgatt tgggtggaac taacttgaga     1260

gttgctatcg tttccatgaa gggagagatc gttaagaagt acactcagtt caacccaaag     1320

acttacgagg agagaatcaa cttgatcttg cagatgtgtg ttgaagctgc tgctgaggct     1380

gttaagttga actgtagaat cttgggtgtt ggtatctcta ctggtggtag agttaatcca     1440

agagagggta tcgttttgca ctccactaag ttgattcagg agtggaactc cgttgatttg     1500

agaactccat tgtccgacac attgcacttg ccagtttggg ttgacaacga cggtaattgt     1560

gctgctttgg ctgagagaaa gttcggtcaa ggaaagggat tggagaactt cgttactttg     1620

atcactggta ctggtattgg tggtggtatc attcaccagc acgagttgat tcacggttct     1680

tccttctgtg ctgctgaatt gggacacttg gttgtttctt tggacggtcc agactgttct     1740

tgtggttccc acggttgtat tgaagcttac gcatcaggaa tggcattgca gagagaggct     1800

aagaagttgc acgacgagga cttgttgttg gttgagggaa tgtctgttcc aaaggacgag     1860

gctgttggtg ctttgcattt gatccaggct gctaagttgg gtaatgctaa ggctcagtcc     1920

atcttgagaa ctgctggtac tgctttggga ttgggtgttg ttaatatctt gcacactatg     1980

aacccatcct tggttatctt gtccggtgtt ttggcttctc actacatcca catcgttaag     2040

gacgttatca gacagcaagc tttgtcctcc gttcaagacg ttgatgttgt tgtttccgac     2100

ttggttgacc cagctttgtt gggtgctgct tccatggttt tggactacac tactagaaga     2160

atctactaat ag                                                         2172


<210>  79
<211>  1854
<212>  DNA
<213>  Pichia pastoris

<400>  79
cagttgagcc agaccgcgct aaacgcatac caattgccaa atcaggcaat tgtgagacag       60

tggtaaaaaa gatgcctgca aagttagatt cacacagtaa gagagatcct actcataaat      120

gaggcgctta tttagtagct agtgatagcc actgcggttc tgctttatgc tatttgttgt      180

atgccttact atctttgttt ggctcctttt tcttgacgtt ttccgttgga gggactccct      240

attctgagtc atgagccgca cagattatcg cccaaaattg acaaaatctt ctggcgaaaa      300

aagtataaaa ggagaaaaaa gctcaccctt ttccagcgta gaaagtatat atcagtcatt      360

gaagactatt atttaaataa cacaatgtct aaaggaaaag tttgtttggc ctactccggt      420

ggtttggata cctccatcat cctagcttgg ttgttggagc agggatacga agtcgttgcc      480

tttttagcca acattggtca agaggaagac tttgaggctg ctagagagaa agctctgaag      540

atcggtgcta ccaagtttat cgtcagtgac gttaggaagg aatttgttga ggaagttttg      600

ttcccagcag tccaagttaa cgctatctac gagaacgtct acttactggg tacctctttg      660

gccagaccag tcattgccaa ggcccaaata gaggttgctg aacaagaagg ttgttttgct      720

gttgcccacg gttgtaccgg aaagggtaac gatcaggtta gatttgagct ttccttttat      780

gctctgaagc ctgacgttgt ctgtatcgcc ccatggagag acccagaatt cttcgaaaga      840

ttcgctggta gaaatgactt gctgaattac gctgctgaga aggatattcc agttgctcag      900

actaaagcca agccatggtc tactgatgag aacatggctc acatctcctt cgaggctggt      960

attctagaag atccaaacac tactcctcca aaggacatgt ggaagctcac tgttgaccca     1020

gaagatgcac cagacaagcc agagttcttt gacgtccact ttgagaaggg taagccagtt     1080

aaattagttc tcgagaacaa aactgaggtc accgatccgg ttgagatctt tttgactgct     1140

aacgccattg ctagaagaaa cggtgttggt agaattgaca ttgtcgagaa cagattcatc     1200

ggaatcaagt ccagaggttg ttatgaaact ccaggtttga ctctactgag aaccactcac     1260

atcgacttgg aaggtcttac cgttgaccgt gaagttagat cgatcagaga cacttttgtt     1320

accccaacct actctaagtt gttatacaac gggttgtact ttaccccaga aggtgagtac     1380

gtcagaacta tgattcagcc ttctcaaaac accgtcaacg gtgttgttag agccaaggcc     1440

tacaaaggta atgtgtataa cctaggaaga tactctgaaa ccgagaaatt gtacgatgct     1500

accgaatctt ccatggatga gttgaccgga ttccaccctc aagaagctgg aggatttatc     1560

acaacacaag ccatcagaat caagaagtac ggagaaagtg tcagagagaa gggaaagttt     1620

ttgggacttt aactcaagta aaaggatagt tgtacaatta tatatacgaa gaataaatca     1680

ttacaaaaag tattcgtttc tttgattctt aacaggattc attttctggg tgtcatcagg     1740

tacagcgctg aatatcttga agttaacatc gagctcatca tcgacgttca tcacactagc     1800

cacgtttccg caacggtagc aataattagg agcggaccac acagtgacga catc           1854


<210>  80
<211>  1308
<212>  DNA
<213>  Homo sapiens

<400>  80
atggactctg ttgaaaaggg tgctgctact tctgtttcca acccaagagg tagaccatcc       60

agaggtagac ctcctaagtt gcagagaaac tccagaggtg gtcaaggtag aggtgttgaa      120

aagccaccac acttggctgc tttgatcttg gctagaggag gttctaaggg tatcccattg      180

aagaacatca agcacttggc tggtgttcca ttgattggat gggttttgag agctgctttg      240

gactctggtg ctttccaatc tgtttgggtt tccactgacc acgacgagat tgagaacgtt      300

gctaagcaat tcggtgctca ggttcacaga agatcctctg aggtttccaa ggactcttct      360

acttccttgg acgctatcat cgagttcttg aactaccaca acgaggttga catcgttggt      420

aacatccaag ctacttcccc atgtttgcac ccaactgact tgcaaaaagt tgctgagatg      480

atcagagaag agggttacga ctccgttttc tccgttgtta gaaggcacca gttcagatgg      540

tccgagattc agaagggtgt tagagaggtt acagagccat tgaacttgaa cccagctaaa      600

agaccaagaa ggcaggattg ggacggtgaa ttgtacgaaa acggttcctt ctacttcgct      660

aagagacact tgatcgagat gggatacttg caaggtggaa agatggctta ctacgagatg      720

agagctgaac actccgttga catcgacgtt gatatcgact ggccaattgc tgagcagaga      780

gttttgagat acggttactt cggaaaggag aagttgaagg agatcaagtt gttggtttgt      840

aacatcgacg gttgtttgac taacggtcac atctacgttt ctggtgacca gaaggagatt      900

atctcctacg acgttaagga cgctattggt atctccttgt tgaagaagtc cggtatcgaa      960

gttagattga tctccgagag agcttgttcc aagcaaacat tgtcctcttt gaagttggac     1020

tgtaagatgg aggtttccgt ttctgacaag ttggctgttg ttgacgaatg gagaaaggag     1080

atgggtttgt gttggaagga agttgcttac ttgggtaacg aagtttctga cgaggagtgt     1140

ttgaagagag ttggtttgtc tggtgctcca gctgatgctt gttccactgc tcaaaaggct     1200

gttggttaca tctgtaagtg taacggtggt agaggtgcta ttagagagtt cgctgagcac     1260

atctgtttgt tgatggagaa agttaataac tcctgtcaga agtagtag                  1308


<210>  81
<211>  1080
<212>  DNA
<213>  Homo sapiens

<400>  81
atgccattgg aattggagtt gtgtcctggt agatgggttg gtggtcaaca cccatgtttc       60

atcatcgctg agatcggtca aaaccaccaa ggagacttgg acgttgctaa gagaatgatc      120

agaatggcta aggaatgtgg tgctgactgt gctaagttcc agaagtccga gttggagttc      180

aagttcaaca gaaaggcttt ggaaagacca tacacttcca agcactcttg gggaaagact      240

tacggagaac acaagagaca cttggagttc tctcacgacc aatacagaga gttgcagaga      300

tacgctgagg aagttggtat cttcttcact gcttctggaa tggacgaaat ggctgttgag      360

ttcttgcacg agttgaacgt tccattcttc aaagttggtt ccggtgacac taacaacttc      420

ccatacttgg aaaagactgc taagaaaggt agaccaatgg ttatctcctc tggaatgcag      480

tctatggaca ctatgaagca ggtttaccag atcgttaagc cattgaaccc aaacttttgt      540

ttcttgcagt gtacttccgc ttacccattg caaccagagg acgttaattt gagagttatc      600

tccgagtacc agaagttgtt cccagacatc ccaattggtt actctggtca cgagactggt      660

attgctattt ccgttgctgc tgttgctttg ggtgctaagg ttttggagag acacatcact      720

ttggacaaga cttggaaggg ttctgatcac tctgcttctt tggaacctgg tgagttggct      780

gaacttgtta gatcagttag attggttgag agagctttgg gttccccaac taagcaattg      840

ttgccatgtg agatggcttg taacgagaag ttgggaaagt ccgttgttgc taaggttaag      900

atcccagagg gtactatctt gactatggac atgttgactg ttaaagttgg agagccaaag      960

ggttacccac cagaggacat ctttaacttg gttggtaaaa aggttttggt tactgttgag     1020

gaggacgaca ctattatgga ggagttggtt gacaaccacg gaaagaagat caagtcctag     1080


<210>  82
<211>  1092
<212>  DNA
<213>  Mus

<400>  82
gtttttcaaa tgccaaagtc ccaggagaaa gttgctgttg gtccagctcc acaagctgtt       60

ttctccaact ccaagcaaga tccaaaggag ggtgttcaaa tcttgtccta cccaagagtt      120

actgctaagg ttaagccaca accatccttg caagtttggg acaaggactc cacttactcc      180

aagttgaacc caagattgtt gaagatttgg agaaactact tgaacatgaa caagtacaag      240

gtttcctaca agggtccagg tccaggtgtt aagttctccg ttgaggcttt gagatgtcac      300

ttgagagacc acgttaacgt ttccatgatc gaggctactg acttcccatt caacactact      360

gaatgggagg gatacttgcc aaaggagaac ttcagaacta aggctggtcc atggcataag      420

tgtgctgttg tttcttctgc tggttccttg aagaactccc agttgggtag agaaattgac      480

aaccacgacg ctgttttgag attcaacggt gctccaactg acaacttcca gcaggatgtt      540

ggtactaaga ctactatcag attggttaac tcccaattgg ttactactga gaagagattc      600

ttgaaggact ccttgtacac tgagggaatc ttgattttgt gggacccatc tgtttaccac      660

gctgacattc cacaatggta tcagaagcca gactacaact tcttcgagac ttacaagtcc      720

tacagaagat tgcacccatc ccagccattc tacatcttga agccacaaat gccatgggaa      780

ttgtgggaca tcatccagga aatttcccca gacttgatcc aaccaaaccc accatcttct      840

ggaatgttgg gtatcatcat catgatgact ttgtgtgacc aggttgacat ctacgagttc      900

ttgccatcca agagaaagac tgatgtttgt tactaccacc agaagttctt cgactccgct      960

tgtactatgg gagcttacca cccattgttg ttcgagaaga acatggttaa gcacttgaac     1020

gaaggtactg acgaggacat ctacttgttc ggaaaggcta ctttgtccgg tttcagaaac     1080

aacagatgtt ag                                                         1092


<210>  83
<211>  1302
<212>  DNA
<213>  Pichia pastoris

<400>  83
actgggcctt tagagggtgc tgaagttgac cccttggtgc ttctggaaaa agaactgaag       60

ggcaccagac aagcgcaact tcctggtatt cctcgtctaa gtggtggtgc cataggatac      120

atctcgtacg attgtattaa gtactttgaa ccaaaaactg aaagaaaact gaaagatgtt      180

ttgcaacttc cggaagcagc tttgatgttg ttcgacacga tcgtggcttt tgacaatgtt      240

tatcaaagat tccaggtaat tggaaacgtt tctctatccg ttgatgactc ggacgaagct      300

attcttgaga aatattataa gacaagagaa gaagtggaaa agatcagtaa agtggtattt      360

gacaataaaa ctgttcccta ctatgaacag aaagatatta ttcaaggcca aacgttcacc      420

tctaatattg gtcaggaagg gtatgaaaac catgttcgca agctgaaaga acatattctg      480

aaaggagaca tcttccaagc tgttccctct caaagggtag ccaggccgac ctcattgcac      540

cctttcaaca tctatcgtca tttgagaact gtcaatcctt ctccatacat gttctatatt      600

gactatctag acttccaagt tgttggtgct tcacctgaat tactagttaa atccgacaac      660

aacaacaaaa tcatcacaca tcctattgct ggaactcttc ccagaggtaa aactatcgaa      720

gaggacgaca attatgctaa gcaattgaag tcgtctttga aagacagggc cgagcacgtc      780

atgctggtag atttggccag aaatgatatt aaccgtgtgt gtgagcccac cagtaccacg      840

gttgatcgtt tattgactgt ggagagattt tctcatgtga tgcatcttgt gtcagaagtc      900

agtggaacat tgagaccaaa caagactcgc ttcgatgctt tcagatccat tttcccagca      960

ggtaccgtct ccggtgctcc gaaggtaaga gcaatgcaac tcataggaga attggaagga     1020

gaaaagagag gtgtttatgc gggggccgta ggacactggt cgtacgatgg aaaatcgatg     1080

gacacatgta ttgccttaag aacaatggtc gtcaaggacg gtgtcgctta ccttcaagcc     1140

ggaggtggaa ttgtctacga ttctgacccc tatgacgagt acatcgaaac catgaacaaa     1200

atgagatcca acaataacac catcttggag gctgagaaaa tctggaccga taggttggcc     1260

agagacgaga atcaaagtga atccgaagaa aacgatcaat ga                        1302


<210>  84
<211>  1085
<212>  DNA
<213>  Pichia pastoris

<400>  84
acggaggacg taagtaggaa tttatgtaat catgccaata catctttaga tttcttcctc       60

ttctttttaa cgaaagacct ccagttttgc actctcgact ctctagtatc ttcccatttc      120

tgttgctgca acctcttgcc ttctgtttcc ttcaattgtt cttctttctt ctgttgcact      180

tggccttctt cctccatctt tcgttttttt tcaagccttt tcagcagttc ttcttccaag      240

agcagttctt tgattttctc tctccaatcc accaaaaaac tggatgaatt caaccgggca      300

tcatcaatgt tccactttct ttctcttatc aataatctac gtgcttcggc atacgaggaa      360

tccagttgct ccctaatcga gtcatccaca aggttagcat gggccttttt cagggtgtca      420

aaagcatctg gagctcgttt attcggagtc ttgtctggat ggatcagcaa agactttttg      480

cggaaagtct ttcttatatc ttccggagaa caacctggtt tcaaatccaa gatggcatag      540

ctgtccaatt tgaaagtgga aagaatcctg ccaatttcct tctctcgtgt cagctcgttc      600

tcctcctttt gcaacaggtc cacttcatct ggcatttttc tttatgttaa ctttaattat      660

tattaattat aaagttgatt atcgttatca aaataatcat attcgagaaa taatccgtcc      720

atgcaatata taaataagaa ttcataataa tgtaatgata acagtacctc tgatgacctt      780

tgatgaaccg caattttctt tccaatgaca agacatccct ataatacaat tatacagttt      840

atatatcaca aataatcacc tttttataag aaaaccgtcc tctccgtaac agaacttatt      900

atccgcacgt tatggttaac acactactaa taccgatata gtgtatgaag tcgctacgag      960

atagccatcc aggaaactta ccaattcatc agcactttca tgatccgatt gttggcttta     1020

ttctttgcga gacagatact tgccaatgaa ataactgatc ccacagatga gaatccggtg     1080

ctcgt                                                                 1085


<210>  85
<211>  747
<212>  DNA
<213>  Pichia pastoris

<400>  85
ttgggggcct ccaggacttg ctgaaatttg ctgactcatc ttcgccatcc aaggataatg       60

agttagctaa tgtgacagtt aatgagtcgt cttgactaac ggggaacatt tcattattta      120

tatccagagt caatttgata gcagagtttg tggttgaaat acctatgatt cgggagactt      180

tgttgtaacg accattatcc acagtttgga ccgtgaaaat gtcatcgaag agagcagacg      240

acatattatc tattgtggta agtgatagtt ggaagtccga ctaaggcatg aaaatgagaa      300

gactgaaaat ttaaagtttt tgaaaacact aatcgggtaa taacttggaa attacgttta      360

cgtgccttta gctcttgtcc ttacccctga taatctatcc atttcccgag agacaatgac      420

atctcggaca gctgagaacc cgttcgatat agagcttcaa gagaatctaa gtccacgttc      480

ttccaattcg tccatattgg aaaacattaa tgagtatgct agaagacatc gcaatgattc      540

gctttcccaa gaatgtgata atgaagatga gaacgaaaat ctcaattata ctgataactt      600

ggccaagttt tcaaagtctg gagtatcaag aaagagctgt atgctaatat ttggtatttg      660

ctttgttatc tggctgtttc tctttgcctt gtatgcgagg gacaatcgat tttccaattt      720

gaacgagtac gttccagatt caaacag                                          747


<210>  86
<211>  924
<212>  DNA
<213>  Pichia pastoris

<400>  86
ctactgggaa ccacgagaca tcactgcagt agtttccaag tggatttcag atcactcatt       60

tgtgaatcct gacaaaactg cgatatgggg gtggtcttac ggtgggttca ctacgcttaa      120

gacattggaa tatgattctg gagaggtttt caaatatggt atggctgttg ctccagtaac      180

taattggctt ttgtatgact ccatctacac tgaaagatac atgaaccttc caaaggacaa      240

tgttgaaggc tacagtgaac acagcgtcat taagaaggtt tccaatttta agaatgtaaa      300

ccgattcttg gtttgtcacg ggactactga tgataacgtg cattttcaga acacactaac      360

cttactggac cagttcaata ttaatggtgt tgtgaattac gatcttcagg tgtatcccga      420

cagtgaacat agcattgccc atcacaacgc aaataaagtg atctacgaga ggttattcaa      480

gtggttagag cgggcattta acgatagatt tttgtaacat tccgtacttc atgccatact      540

atatatcctg caaggtttcc ctttcagaca caataattgc tttgcaattt tacataccac      600

caattggcaa aaataatctc ttcagtaagt tgaatgcttt tcaagccagc accgtgagaa      660

attgctacag cgcgcattct aacatcactt taaaattccc tcgccggtgc tcactggagt      720

ttccaaccct tagcttatca aaatcgggtg ataactctga gttttttttt tcacttctat      780

tcctaaacct tcgcccaatg ctaccacctc caatcaacat cccgaaatgg atagaagaga      840

atggacatct cttgcaacct ccggttaata attactgtct ccacagagga ggatttacgg      900

taatgattgt aggtgggcct aatg                                             924


<210>  87
<211>  980
<212>  DNA
<213>  Pichia pastoris

<400>  87
cacctgggcc tgttgctgct ggtactgctg ttggaactgt tggtattgtt gctgatctaa       60

ggccgcctgt tccacaccgt gtgtatcgaa tgcttgggca aaatcatcgc ctgccggagg      120

ccccactacc gcttgttcct cctgctcttg tttgttttgc tcattgatga tatcggcgtc      180

aatgaattga tcctcaatcg tgtggtggtg gtgtcgtgat tcctcttctt tcttgagtgc      240

cttatccata ttcctatctt agtgtaccaa taattttgtt aaacacacgc tgttgtttat      300

gaaaagtcgt caaaaggtta aaaattctac ttggtgtgtg tcagagaaag tagtgcagac      360

ccccagtttg ttgactagtt gagaaggcgg ctcactattg cgcgaatagc atgagaaatt      420

tgcaaacatc tggcaaagtg gtcaatacct gccaacctgc caatcttcgc gacggaggct      480

gttaagcggg ttgggttccc aaagtgaatg gatattacgg gcaggaaaaa cagccccttc      540

cacactagtc tttgctactg acatcttccc tctcatgtat cccgaacaca agtatcggga      600

gtatcaacgg agggtgccct tatggcagta ctccctgttg gtgattgtac tgctatacgg      660

gtctcatttg cttatcagca ccatcaactt gatacactat aaccacaaaa attatcatgc      720

acacccagtc aatagtggta tcgttcttaa tgagtttgct gatgacgatt cattctcttt      780

gaatggcact ctgaacttgg agaactggag aaatggtacc ttttccccta aatttcattc      840

cattcagtgg accgaaatag gtcaggaaga tgaccaggga tattacattc tctcttccaa      900

ttcctcttac atagtaaagt ctttatccga cccagacttt gaatctgttc tattcaacga      960

gtctacaatc acttacaacg                                                  980


<210>  88
<211>  1117
<212>  DNA
<213>  Pichia pastoris

<400>  88
ggcagcaaag ccttacgttg atgagaatag actggccatt tggggttggt cttatggagg       60

ttacatgacg ctaaaggttt tagaacagga taaaggtgaa acattcaaat atggaatgtc      120

tgttgcccct gtgacgaatt ggaaattcta tgattctatc tacacagaaa gatacatgca      180

cactcctcag gacaatccaa actattataa ttcgtcaatc catgagattg ataatttgaa      240

gggagtgaag aggttcttgc taatgcacgg aactggtgac gacaatgttc acttccaaaa      300

tacactcaaa gttctagatt tatttgattt acatggtctt gaaaactatg atatccacgt      360

gttccctgat agtgatcaca gtattagata tcacaacggt aatgttatag tgtatgataa      420

gctattccat tggattaggc gtgcattcaa ggctggcaaa taaataggtg caaaaatatt      480

attagacttt ttttttcgtt cgcaagttat tactgtgtac cataccgatc caatccgtat      540

tgtaattcat gttctagatc caaaatttgg gactctaatt catgaggtct aggaagatga      600

tcatctctat agttttcagc ggggggctcg atttgcggtt ggtcaaagct aacatcaaaa      660

tgtttgtcag gttcagtgaa tggtaactgc tgctcttgaa ttggtcgtct gacaaattct      720

ctaagtgata gcacttcatc tacaatcatt tgcttcatcg tttctatatc gtccacgacc      780

tcaaacgaga aatcgaattt ggaagaacag acgggctcat cgttaggatc atgccaaacc      840

ttgagatatg gatgctctaa agcctcagta actgtaattc tgtgagtggg atctaccgtg      900

agcattcgat ccagtaagtc tatcgcttca gggttggcac cgggaaataa ctggctgaat      960

gggatcttgg gcatgaatgg cagggagcga acataatcct gggcacgctc tgatctgata     1020

gactgaagtg tctcttccga aacagtaccc agcgtactca aaatcaagtt caattgatcc     1080

acatagtctc ttcctctaaa aatgggtcgg ccaccta                              1117


<210>  89
<211>  1666
<212>  DNA
<213>  Escherichia coli

<400>  89
gatctgttta gcttgcctcg tccccgccgg gtcacccggc cagcgacatg gaggcccaga       60

ataccctcct tgacagtctt gacgtgcgca gctcaggggc atgatgtgac tgtcgcccgt      120

acatttagcc catacatccc catgtataat catttgcatc catacatttt gatggccgca      180

cggcgcgaag caaaaattac ggctcctcgc tgcggacctg cgagcaggga aacgctcccc      240

tcacagacgc gttgaattgt ccccacgccg cgcccctgta gagaaatata aaaggttagg      300

atttgccact gaggttcttc tttcatatac ttccttttaa aatcttgcta ggatacagtt      360

ctcacatcac atccgaacat aaacaaccat gggtaaaaag cctgaactca ccgcgacgtc      420

tgtcgagaag tttctgatcg aaaagttcga cagcgtctcc gacctgatgc agctctcgga      480

gggcgaagaa tctcgtgctt tcagcttcga tgtaggaggg cgtggatatg tcctgcgggt      540

aaatagctgc gccgatggtt tctacaaaga tcgttatgtt tatcggcact ttgcatcggc      600

cgcgctcccg attccggaag tgcttgacat tggggaattc agcgagagcc tgacctattg      660

catctcccgc cgtgcacagg gtgtcacgtt gcaagacctg cctgaaaccg aactgcccgc      720

tgttctgcag ccggtcgcgg aggccatgga tgcgatcgct gcggccgatc ttagccagac      780

gagcgggttc ggcccattcg gaccgcaagg aatcggtcaa tacactacat ggcgtgattt      840

catatgcgcg attgctgatc cccatgtgta tcactggcaa actgtgatgg acgacaccgt      900

cagtgcgtcc gtcgcgcagg ctctcgatga gctgatgctt tgggccgagg actgccccga      960

agtccggcac ctcgtgcacg cggatttcgg ctccaacaat gtcctgacgg acaatggccg     1020

cataacagcg gtcattgact ggagcgaggc gatgttcggg gattcccaat acgaggtcgc     1080

caacatcttc ttctggaggc cgtggttggc ttgtatggag cagcagacgc gctacttcga     1140

gcggaggcat ccggagcttg caggatcgcc gcggctccgg gcgtatatgc tccgcattgg     1200

tcttgaccaa ctctatcaga gcttggttga cggcaatttc gatgatgcag cttgggcgca     1260

gggtcgatgc gacgcaatcg tccgatccgg agccgggact gtcgggcgta cacaaatcgc     1320

ccgcagaagc gcggccgtct ggaccgatgg ctgtgtagaa gtactcgccg atagtggaaa     1380

ccgacgcccc agcactcgtc cgagggcaaa ggaataatca gtactgacaa taaaaagatt     1440

cttgttttca agaacttgtc atttgtatag tttttttata ttgtagttgt tctattttaa     1500

tcaaatgtta gcgtgattta tatttttttt cgcctcgaca tcatctgccc agatgcgaag     1560

ttaagtgcgc agaaagtaat atcatgcgtc aatcgtatgt gaatgctggt cgctatactg     1620

ctgtcgattc gatactaacg ccgccatcca gtgtcgaaaa cgagct                    1666


<210>  90
<211>  365
<212>  DNA
<213>  Pichia pastoris

<400>  90
acgacggcca aattcatgat acacactctg tttcagctgg tttggactac cctggagttg       60

gtcctgaatt ggctgcctgg aaagcaaatg gtagagccca attttccgct gtaactgatg      120

cccaagcatt agagggattc aaaatcctgt ctcaattgga agggatcatt ccagcactag      180

agtctagtca tgcaatctac ggcgcattgc aaattgcaaa gactatgtct tcggaccagt      240

ccttagttat taatgtatct ggaaggggtg ataaggacgt ccagagtgta gctgagattt      300

tacctaaatt gggacctcaa attggatggg atttgcgttt cagcgaagac attactaaag      360

agtga                                                                  365


<210>  91
<211>  613
<212>  DNA
<213>  Pichia pastoris

<400>  91
tcgatagcac aatattcaac ttgactgggt gttaagaact aagagctctg ggaaactttg       60

tatttattac taccaacaca gtcaaattat tggatgtgtt tttttttcca gtacatttca      120

ctgagcagtt tgttatactc ggtctttaat ctccatatac atgcagattg taatacagat      180

ctgaacagtt tgattctgat tgatcttgcc accaatattc tatttttgta tcaagtaaca      240

gagtcaatga tcattggtaa cgtaacggtt ttcgtgtata gtagttagag cccatcttgt      300

aacctcattt cctcccatat taaagtatca gtgattcgct ggaacgatta actaagaaaa      360

aaaaaatatc tgcacatact catcagtctg taaatctaag tcaaaactgc tgtatccaat      420

agaaatcggg atatacctgg atgttttttc cacataaaca aacgggagtt cagcttactt      480

atggtgttga tgcaattcag tatgatccta ccaataaaac gaaactttgg gattttggct      540

gtttgaggga tcaaaagctg cacctttaca agattgacgg atcgaccatt agaccaaagc      600

aaatggccac caa                                                         613


<210>  92
<211>  21
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  92

Met Lys Leu Lys Thr Val Arg Ser Ala Val Leu Ser Ser Leu Phe Ala 
1               5                   10                  15      


Ser Gln Val Leu Gly 
            20      


<210>  93
<211>  44
<212>  PRT
<213>  Artificial sequence

<220>
<223>  TA57 pro

<400>  93

Gln Pro Ile Asp Asp Thr Glu Ser Gln Thr Thr Ser Val Asn Leu Met 
1               5                   10                  15      


Ala Asp Asp Thr Glu Ser Ala Phe Ala Thr Gln Thr Asn Ser Gly Gly 
            20                  25                  30          


Leu Asp Val Val Gly Leu Ile Ser Met Ala Lys Arg 
        35                  40                  


<210>  94
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal spacer

<400>  94

Glu Glu Gly Glu Pro Lys 
1               5       


<210>  95
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Glycosylated insulin B chain P28N

<400>  95

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asn Lys Thr 
            20                  25                  30  


<210>  96
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  96

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  97
<211>  125
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Pre-proinsulin analogue: Yps1ss+TA57 propeptide+N-terminal 
       spacer+B chain P28N+C-peptide "AAK"+ insulin A chain

<400>  97

Met Lys Leu Lys Thr Val Arg Ser Ala Val Leu Ser Ser Leu Phe Ala 
1               5                   10                  15      


Ser Gln Val Leu Gly Gln Pro Ile Asp Asp Thr Glu Ser Gln Thr Thr 
            20                  25                  30          


Ser Val Asn Leu Met Ala Asp Asp Thr Glu Ser Ala Phe Ala Thr Gln 
        35                  40                  45              


Thr Asn Ser Gly Gly Leu Asp Val Val Gly Leu Ile Ser Met Ala Lys 
    50                  55                  60                  


Arg Glu Glu Gly Glu Pro Lys Phe Val Asn Gln His Leu Cys Gly Ser 
65                  70                  75                  80  


His Leu Val Glu Ala Leu Tyr Leu Val Cys Gly Glu Arg Gly Phe Phe 
                85                  90                  95      


Tyr Thr Asn Lys Thr Ala Ala Lys Gly Ile Val Glu Gln Cys Cys Thr 
            100                 105                 110         


Ser Ile Cys Ser Leu Tyr Gln Leu Glu Asn Tyr Cys Asn 
        115                 120                 125 


<210>  98
<211>  378
<212>  DNA
<213>  Artificial sequence

<220>
<223>  DNA encoding pre-proinsulin analogue:

       Yps1ss+TA57 propeptide+N-terminal spacer+B chain P28N+C-peptide 
       "AAK"+ insulin A chain

<400>  98
atgaagttga agactgttag atccgctgtt ttgtcttctt tgtttgcttc tcaagttttg       60

ggtcaaccaa ttgatgatac tgaatctcaa actacttctg ttaacttgat ggctgatgat      120

actgaatctg cttttgctac tcaaactaac tctggtggtt tggatgttgt tggtttgatt      180

tctatggcta agagagaaga aggtgaacca aagtttgtta accaacattt gtgtggttct      240

catttggttg aagctttgta cttggtttgt ggtgaaagag gtttttttta cactaacaag      300

actgctgcta agggtattgt tgaacaatgt tgtacttcta tttgttcttt gtaccaattg      360

gaaaactact gtaactaa                                                    378


