                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
 
<120>  NOVEL ANTIGEN BINDING PROTEIN AND ITS USE AS ADDRESSING PRODUCT 
       FOR THE TREATMENT OF CANCER

<130>  361508D30354

<150>  EP11306416.6
<151>  2011-11-03

<160>  35    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Light chain CDR-L1 from 1613F12 antibody (IMGT numbering)

<400>  1

Lys Ser Ile Ser Lys Tyr 
1               5       


<210>  2
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Light chain CDR-L2 from 1613F12 antibody (IMGT numbering)

<400>  2

Ser Gly Ser 
1           


<210>  3
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Light chain CDR-L3 from 1613F12 antibody (IMGT numbering)

<400>  3

Gln Gln His His Glu Tyr Pro Leu Thr 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain CDR-H1 from 1613F12 antibody (IMGT numbering)

<400>  4

Gly Phe Asn Ile Arg Asp Thr Tyr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain CDR-H2 from 1613F12 antibody (IMGT numbering)

<400>  5

Leu Asp Pro Ala Asn Gly His Thr 
1               5               


<210>  6
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain CDR-H3 from 1613F12 antibody (IMGT numbering)

<400>  6

Ala Arg Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp 
1               5                   10                  15      


Tyr 
    


<210>  7
<211>  107
<212>  PRT
<213>  artificial

<220>
<223>  Light chain Mu variable domain

<400>  7

Asp Val Gln Ile Thr Gln Ser Pro Ser Tyr Leu Ala Thr Ser Pro Gly 
1               5                   10                  15      


Glu Thr Ile Thr Ile Asn Cys Arg Ala Ser Lys Ser Ile Ser Lys Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Glu Lys Pro Gly Lys Thr Asn Lys Leu Leu Ile 
        35                  40                  45              


Tyr Ser Gly Ser Thr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Phe Cys Gln Gln His His Glu Tyr Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Glu Leu Glu Leu Lys 
            100                 105         


<210>  8
<211>  124
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain Mu variable domain

<400>  8

Glu Val His Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Arg Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Leu Asp Pro Ala Asn Gly His Thr Lys Tyr Gly Pro Asn Phe 
    50                  55                  60                  


Gln Gly Arg Ala Thr Met Thr Ser Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp 
            100                 105                 110         


Tyr Trp Gly Gln Gly Thr Thr Leu Ser Val Ser Ser 
        115                 120                 


<210>  9
<211>  11
<212>  PRT
<213>  artificial

<220>
<223>  Light chain CDR-L1 from 1613F12 antibody (Kabat numbering)

<400>  9

Arg Ala Ser Lys Ser Ile Ser Lys Tyr Leu Ala 
1               5                   10      


<210>  10
<211>  7
<212>  PRT
<213>  artificial

<220>
<223>  Light chain CDR-L2 from 1613F12 antibody (Kabat numbering)

<400>  10

Ser Gly Ser Thr Leu Gln Ser 
1               5           


<210>  11
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Light chain CDR-L3 from 1613F12 antibody (Kabat numbering)

<400>  11

Gln Gln His His Glu Tyr Pro Leu Thr 
1               5                   


<210>  12
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain CDR-H1 from 1613F12 antibody (Kabat numbering)

<400>  12

Arg Asp Thr Tyr Ile His 
1               5       


<210>  13
<211>  17
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain CDR-H2 from 1613F12 antibody (Kabat numbering)

<400>  13

Arg Leu Asp Pro Ala Asn Gly His Thr Lys Tyr Gly Pro Asn Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  14
<211>  15
<212>  PRT
<213>  artificial

<220>
<223>  Heavy chain CDR-H3 from 1613F12 antibody (Kabat numbering)

<400>  14

Gly Ala Tyr Tyr Tyr Gly Ser Ser Gly Leu Phe Tyr Phe Asp Tyr 
1               5                   10                  15  


<210>  15
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Light chain CDR-L1 from 1613F12 antibody (IMGT numbering)

<400>  15
aagagcatta gcaaatat                                                     18


<210>  16
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Light chain CDR-L2 from 1613F12 antibody (IMGT numbering)

<400>  16
tctggatcc                                                                9


<210>  17
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Light chain CDR-L3 from 1613F12 antibody (IMGT numbering)

<400>  17
caacagcatc atgaataccc gctcacg                                           27


<210>  18
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain CDR-H1 from 1613F12 antibody (IMGT numbering)

<400>  18
ggcttcaaca ttagagacac ctat                                              24


<210>  19
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain CDR-H2 from 1613F12 antibody (IMGT numbering)

<400>  19
cttgatcctg cgaatggtca tact                                              24


<210>  20
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain CDR-H3 from 1613F12 antibody (IMGT numbering)

<400>  20
gctagagggg cctattacta cggtagtagt ggtctcttct actttgacta c                51


<210>  21
<211>  321
<212>  DNA
<213>  artificial

<220>
<223>  Light chain Mu variable domain

<400>  21
gatgtccaga taacccagtc tccatcttat cttgctacat ctcctggaga aaccattact       60

attaattgca gggcaagtaa gagcattagc aaatatttag cctggtatca agaaaaacct      120

gggaaaacta ataagcttct tatctactct ggatccactt tgcaatctgg agttccatca      180

aggttcagtg gcagtggatc tggtacagat ttcactctca ccatcagtag cctggagcct      240

gaagattttg caatgtattt ctgtcaacag catcatgaat acccgctcac gttcggtgct      300

gggaccgagc tggagctgaa a                                                321


<210>  22
<211>  372
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain Mu variable domain

<400>  22
gaggttcacc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg       60

tcctgcacag cttctggctt caacattaga gacacctata tccattgggt gaaacagagg      120

cctgaacagg gcctggagtg gattggaagg cttgatcctg cgaatggtca tactaaatat      180

ggcccgaact tccagggcag ggccactatg acatcagaca catcctccaa cacggcctac      240

ctgcagctca gcagcctgac atctgaggac actgccgtct attactgtgc tagaggggcc      300

tattactacg gtagtagtgg tctcttctac tttgactact ggggccaagg caccactctc      360

tcagtctcct ca                                                          372


<210>  23
<211>  33
<212>  DNA
<213>  artificial

<220>
<223>  Light chain CDR-L1 from 1613F12 antibody (Kabat numbering)

<400>  23
agggcaagta agagcattag caaatattta gcc                                    33


<210>  24
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Light chain CDR-L2 from 1613F12 antibody (Kabat numbering)

<400>  24
tctggatcca ctttgcaatc t                                                 21


<210>  25
<211>  27
<212>  DNA
<213>  artificial

<220>
<223>  Light chain CDR-L3 from 1613F12 antibody (Kabat numbering)

<400>  25
caacagcatc atgaataccc gctcacg                                           27


<210>  26
<211>  18
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain CDR-H1 from 1613F12 antibody (Kabat numbering)

<400>  26
agagacacct atatccat                                                     18


<210>  27
<211>  51
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain CDR-H2 from 1613F12 antibody (Kabat numbering)

<400>  27
aggcttgatc ctgcgaatgg tcatactaaa tatggcccga acttccaggg c                51


<210>  28
<211>  45
<212>  DNA
<213>  artificial

<220>
<223>  Heavy chain CDR-H3 from 1613F12 antibody (Kabat numbering)

<400>  28
ggggcctatt actacggtag tagtggtctc ttctactttg actac                       45


<210>  29
<211>  894
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Protein Axl (with peptide signal)

<400>  29

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp Tyr Val Leu Leu Gly Ala Val Val Ala Ala Ala Cys Val 
    450                 455                 460                 


Leu Ile Leu Ala Leu Phe Leu Val His Arg Arg Lys Lys Glu Thr Arg 
465                 470                 475                 480 


Tyr Gly Glu Val Phe Glu Pro Thr Val Glu Arg Gly Glu Leu Val Val 
                485                 490                 495     


Arg Tyr Arg Val Arg Lys Ser Tyr Ser Arg Arg Thr Thr Glu Ala Thr 
            500                 505                 510         


Leu Asn Ser Leu Gly Ile Ser Glu Glu Leu Lys Glu Lys Leu Arg Asp 
        515                 520                 525             


Val Met Val Asp Arg His Lys Val Ala Leu Gly Lys Thr Leu Gly Glu 
    530                 535                 540                 


Gly Glu Phe Gly Ala Val Met Glu Gly Gln Leu Asn Gln Asp Asp Ser 
545                 550                 555                 560 


Ile Leu Lys Val Ala Val Lys Thr Met Lys Ile Ala Ile Cys Thr Arg 
                565                 570                 575     


Ser Glu Leu Glu Asp Phe Leu Ser Glu Ala Val Cys Met Lys Glu Phe 
            580                 585                 590         


Asp His Pro Asn Val Met Arg Leu Ile Gly Val Cys Phe Gln Gly Ser 
        595                 600                 605             


Glu Arg Glu Ser Phe Pro Ala Pro Val Val Ile Leu Pro Phe Met Lys 
    610                 615                 620                 


His Gly Asp Leu His Ser Phe Leu Leu Tyr Ser Arg Leu Gly Asp Gln 
625                 630                 635                 640 


Pro Val Tyr Leu Pro Thr Gln Met Leu Val Lys Phe Met Ala Asp Ile 
                645                 650                 655     


Ala Ser Gly Met Glu Tyr Leu Ser Thr Lys Arg Phe Ile His Arg Asp 
            660                 665                 670         


Leu Ala Ala Arg Asn Cys Met Leu Asn Glu Asn Met Ser Val Cys Val 
        675                 680                 685             


Ala Asp Phe Gly Leu Ser Lys Lys Ile Tyr Asn Gly Asp Tyr Tyr Arg 
    690                 695                 700                 


Gln Gly Arg Ile Ala Lys Met Pro Val Lys Trp Ile Ala Ile Glu Ser 
705                 710                 715                 720 


Leu Ala Asp Arg Val Tyr Thr Ser Lys Ser Asp Val Trp Ser Phe Gly 
                725                 730                 735     


Val Thr Met Trp Glu Ile Ala Thr Arg Gly Gln Thr Pro Tyr Pro Gly 
            740                 745                 750         


Val Glu Asn Ser Glu Ile Tyr Asp Tyr Leu Arg Gln Gly Asn Arg Leu 
        755                 760                 765             


Lys Gln Pro Ala Asp Cys Leu Asp Gly Leu Tyr Ala Leu Met Ser Arg 
    770                 775                 780                 


Cys Trp Glu Leu Asn Pro Gln Asp Arg Pro Ser Phe Thr Glu Leu Arg 
785                 790                 795                 800 


Glu Asp Leu Glu Asn Thr Leu Lys Ala Leu Pro Pro Ala Gln Glu Pro 
                805                 810                 815     


Asp Glu Ile Leu Tyr Val Asn Met Asp Glu Gly Gly Gly Tyr Pro Glu 
            820                 825                 830         


Pro Pro Gly Ala Ala Gly Gly Ala Asp Pro Pro Thr Gln Pro Asp Pro 
        835                 840                 845             


Lys Asp Ser Cys Ser Cys Leu Thr Ala Ala Glu Val His Pro Ala Gly 
    850                 855                 860                 


Arg Tyr Val Leu Cys Pro Ser Thr Thr Pro Ser Pro Ala Gln Pro Ala 
865                 870                 875                 880 


Asp Arg Gly Ser Pro Ala Ala Pro Gly Gln Glu Asp Gly Ala 
                885                 890                 


<210>  30
<211>  869
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Protein Axl (without peptide signal)

<400>  30

Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val Gly Asn Pro 
1               5                   10                  15      


Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu Arg Cys Gln 
            20                  25                  30          


Leu Gln Val Gln Gly Glu Pro Pro Glu Val His Trp Leu Arg Asp Gly 
        35                  40                  45              


Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val Pro Leu Gly 
    50                  55                  60                  


Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser Gln Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln Cys Leu Val Phe Leu 
                85                  90                  95      


Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr Val Gly Leu Glu Gly 
            100                 105                 110         


Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala Ala Asn 
        115                 120                 125             


Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu Pro Val 
    130                 135                 140                 


Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala Pro Gly 
145                 150                 155                 160 


His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys Thr Ser 
                165                 170                 175     


Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr Ser Arg 
            180                 185                 190         


Thr Ala Thr Ile Thr Val Leu Pro Gln Gln Pro Arg Asn Leu His Leu 
        195                 200                 205             


Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr Pro Gly Leu 
    210                 215                 220                 


Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala Val Leu Ser 
225                 230                 235                 240 


Asn Asp Gly Met Gly Ile Gln Ala Gly Glu Pro Asp Pro Pro Glu Glu 
                245                 250                 255     


Pro Leu Thr Ser Gln Ala Ser Val Pro Pro His Gln Leu Arg Leu Gly 
            260                 265                 270         


Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala Cys Thr Ser 
        275                 280                 285             


Ser Gln Gly Pro Ser Ser Trp Thr His Trp Leu Pro Val Glu Thr Pro 
    290                 295                 300                 


Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr Arg Asn 
305                 310                 315                 320 


Gly Ser Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro Leu Gln 
                325                 330                 335     


Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp Thr Pro 
            340                 345                 350         


Glu Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu Glu Leu 
        355                 360                 365             


Gln Gly Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala Ala Tyr 
    370                 375                 380                 


Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu Glu Ala 
385                 390                 395                 400 


Trp Arg Pro Gly Gln Ala Gln Pro Val His Gln Leu Val Lys Glu Pro 
                405                 410                 415     


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp Tyr Val Leu Leu Gly Ala 
            420                 425                 430         


Val Val Ala Ala Ala Cys Val Leu Ile Leu Ala Leu Phe Leu Val His 
        435                 440                 445             


Arg Arg Lys Lys Glu Thr Arg Tyr Gly Glu Val Phe Glu Pro Thr Val 
    450                 455                 460                 


Glu Arg Gly Glu Leu Val Val Arg Tyr Arg Val Arg Lys Ser Tyr Ser 
465                 470                 475                 480 


Arg Arg Thr Thr Glu Ala Thr Leu Asn Ser Leu Gly Ile Ser Glu Glu 
                485                 490                 495     


Leu Lys Glu Lys Leu Arg Asp Val Met Val Asp Arg His Lys Val Ala 
            500                 505                 510         


Leu Gly Lys Thr Leu Gly Glu Gly Glu Phe Gly Ala Val Met Glu Gly 
        515                 520                 525             


Gln Leu Asn Gln Asp Asp Ser Ile Leu Lys Val Ala Val Lys Thr Met 
    530                 535                 540                 


Lys Ile Ala Ile Cys Thr Arg Ser Glu Leu Glu Asp Phe Leu Ser Glu 
545                 550                 555                 560 


Ala Val Cys Met Lys Glu Phe Asp His Pro Asn Val Met Arg Leu Ile 
                565                 570                 575     


Gly Val Cys Phe Gln Gly Ser Glu Arg Glu Ser Phe Pro Ala Pro Val 
            580                 585                 590         


Val Ile Leu Pro Phe Met Lys His Gly Asp Leu His Ser Phe Leu Leu 
        595                 600                 605             


Tyr Ser Arg Leu Gly Asp Gln Pro Val Tyr Leu Pro Thr Gln Met Leu 
    610                 615                 620                 


Val Lys Phe Met Ala Asp Ile Ala Ser Gly Met Glu Tyr Leu Ser Thr 
625                 630                 635                 640 


Lys Arg Phe Ile His Arg Asp Leu Ala Ala Arg Asn Cys Met Leu Asn 
                645                 650                 655     


Glu Asn Met Ser Val Cys Val Ala Asp Phe Gly Leu Ser Lys Lys Ile 
            660                 665                 670         


Tyr Asn Gly Asp Tyr Tyr Arg Gln Gly Arg Ile Ala Lys Met Pro Val 
        675                 680                 685             


Lys Trp Ile Ala Ile Glu Ser Leu Ala Asp Arg Val Tyr Thr Ser Lys 
    690                 695                 700                 


Ser Asp Val Trp Ser Phe Gly Val Thr Met Trp Glu Ile Ala Thr Arg 
705                 710                 715                 720 


Gly Gln Thr Pro Tyr Pro Gly Val Glu Asn Ser Glu Ile Tyr Asp Tyr 
                725                 730                 735     


Leu Arg Gln Gly Asn Arg Leu Lys Gln Pro Ala Asp Cys Leu Asp Gly 
            740                 745                 750         


Leu Tyr Ala Leu Met Ser Arg Cys Trp Glu Leu Asn Pro Gln Asp Arg 
        755                 760                 765             


Pro Ser Phe Thr Glu Leu Arg Glu Asp Leu Glu Asn Thr Leu Lys Ala 
    770                 775                 780                 


Leu Pro Pro Ala Gln Glu Pro Asp Glu Ile Leu Tyr Val Asn Met Asp 
785                 790                 795                 800 


Glu Gly Gly Gly Tyr Pro Glu Pro Pro Gly Ala Ala Gly Gly Ala Asp 
                805                 810                 815     


Pro Pro Thr Gln Pro Asp Pro Lys Asp Ser Cys Ser Cys Leu Thr Ala 
            820                 825                 830         


Ala Glu Val His Pro Ala Gly Arg Tyr Val Leu Cys Pro Ser Thr Thr 
        835                 840                 845             


Pro Ser Pro Ala Gln Pro Ala Asp Arg Gly Ser Pro Ala Ala Pro Gly 
    850                 855                 860                 


Gln Glu Asp Gly Ala 
865                 


<210>  31
<211>  451
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  extracellular domain of the protein Axl (with the peptide signal)

<400>  31

Met Ala Trp Arg Cys Pro Arg Met Gly Arg Val Pro Leu Ala Trp Cys 
1               5                   10                  15      


Leu Ala Leu Cys Gly Trp Ala Cys Met Ala Pro Arg Gly Thr Gln Ala 
            20                  25                  30          


Glu Glu Ser Pro Phe Val Gly Asn Pro Gly Asn Ile Thr Gly Ala Arg 
        35                  40                  45              


Gly Leu Thr Gly Thr Leu Arg Cys Gln Leu Gln Val Gln Gly Glu Pro 
    50                  55                  60                  


Pro Glu Val His Trp Leu Arg Asp Gly Gln Ile Leu Glu Leu Ala Asp 
65                  70                  75                  80  


Ser Thr Gln Thr Gln Val Pro Leu Gly Glu Asp Glu Gln Asp Asp Trp 
                85                  90                  95      


Ile Val Val Ser Gln Leu Arg Ile Thr Ser Leu Gln Leu Ser Asp Thr 
            100                 105                 110         


Gly Gln Tyr Gln Cys Leu Val Phe Leu Gly His Gln Thr Phe Val Ser 
        115                 120                 125             


Gln Pro Gly Tyr Val Gly Leu Glu Gly Leu Pro Tyr Phe Leu Glu Glu 
    130                 135                 140                 


Pro Glu Asp Arg Thr Val Ala Ala Asn Thr Pro Phe Asn Leu Ser Cys 
145                 150                 155                 160 


Gln Ala Gln Gly Pro Pro Glu Pro Val Asp Leu Leu Trp Leu Gln Asp 
                165                 170                 175     


Ala Val Pro Leu Ala Thr Ala Pro Gly His Gly Pro Gln Arg Ser Leu 
            180                 185                 190         


His Val Pro Gly Leu Asn Lys Thr Ser Ser Phe Ser Cys Glu Ala His 
        195                 200                 205             


Asn Ala Lys Gly Val Thr Thr Ser Arg Thr Ala Thr Ile Thr Val Leu 
    210                 215                 220                 


Pro Gln Gln Pro Arg Asn Leu His Leu Val Ser Arg Gln Pro Thr Glu 
225                 230                 235                 240 


Leu Glu Val Ala Trp Thr Pro Gly Leu Ser Gly Ile Tyr Pro Leu Thr 
                245                 250                 255     


His Cys Thr Leu Gln Ala Val Leu Ser Asn Asp Gly Met Gly Ile Gln 
            260                 265                 270         


Ala Gly Glu Pro Asp Pro Pro Glu Glu Pro Leu Thr Ser Gln Ala Ser 
        275                 280                 285             


Val Pro Pro His Gln Leu Arg Leu Gly Ser Leu His Pro His Thr Pro 
    290                 295                 300                 


Tyr His Ile Arg Val Ala Cys Thr Ser Ser Gln Gly Pro Ser Ser Trp 
305                 310                 315                 320 


Thr His Trp Leu Pro Val Glu Thr Pro Glu Gly Val Pro Leu Gly Pro 
                325                 330                 335     


Pro Glu Asn Ile Ser Ala Thr Arg Asn Gly Ser Gln Ala Phe Val His 
            340                 345                 350         


Trp Gln Glu Pro Arg Ala Pro Leu Gln Gly Thr Leu Leu Gly Tyr Arg 
        355                 360                 365             


Leu Ala Tyr Gln Gly Gln Asp Thr Pro Glu Val Leu Met Asp Ile Gly 
    370                 375                 380                 


Leu Arg Gln Glu Val Thr Leu Glu Leu Gln Gly Asp Gly Ser Val Ser 
385                 390                 395                 400 


Asn Leu Thr Val Cys Val Ala Ala Tyr Thr Ala Ala Gly Asp Gly Pro 
                405                 410                 415     


Trp Ser Leu Pro Val Pro Leu Glu Ala Trp Arg Pro Gly Gln Ala Gln 
            420                 425                 430         


Pro Val His Gln Leu Val Lys Glu Pro Ser Thr Pro Ala Phe Ser Trp 
        435                 440                 445             


Pro Trp Trp 
    450     


<210>  32
<211>  426
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  extracellular domain of the protein Axl (without the peptide 
       signal)

<400>  32

Ala Pro Arg Gly Thr Gln Ala Glu Glu Ser Pro Phe Val Gly Asn Pro 
1               5                   10                  15      


Gly Asn Ile Thr Gly Ala Arg Gly Leu Thr Gly Thr Leu Arg Cys Gln 
            20                  25                  30          


Leu Gln Val Gln Gly Glu Pro Pro Glu Val His Trp Leu Arg Asp Gly 
        35                  40                  45              


Gln Ile Leu Glu Leu Ala Asp Ser Thr Gln Thr Gln Val Pro Leu Gly 
    50                  55                  60                  


Glu Asp Glu Gln Asp Asp Trp Ile Val Val Ser Gln Leu Arg Ile Thr 
65                  70                  75                  80  


Ser Leu Gln Leu Ser Asp Thr Gly Gln Tyr Gln Cys Leu Val Phe Leu 
                85                  90                  95      


Gly His Gln Thr Phe Val Ser Gln Pro Gly Tyr Val Gly Leu Glu Gly 
            100                 105                 110         


Leu Pro Tyr Phe Leu Glu Glu Pro Glu Asp Arg Thr Val Ala Ala Asn 
        115                 120                 125             


Thr Pro Phe Asn Leu Ser Cys Gln Ala Gln Gly Pro Pro Glu Pro Val 
    130                 135                 140                 


Asp Leu Leu Trp Leu Gln Asp Ala Val Pro Leu Ala Thr Ala Pro Gly 
145                 150                 155                 160 


His Gly Pro Gln Arg Ser Leu His Val Pro Gly Leu Asn Lys Thr Ser 
                165                 170                 175     


Ser Phe Ser Cys Glu Ala His Asn Ala Lys Gly Val Thr Thr Ser Arg 
            180                 185                 190         


Thr Ala Thr Ile Thr Val Leu Pro Gln Gln Pro Arg Asn Leu His Leu 
        195                 200                 205             


Val Ser Arg Gln Pro Thr Glu Leu Glu Val Ala Trp Thr Pro Gly Leu 
    210                 215                 220                 


Ser Gly Ile Tyr Pro Leu Thr His Cys Thr Leu Gln Ala Val Leu Ser 
225                 230                 235                 240 


Asn Asp Gly Met Gly Ile Gln Ala Gly Glu Pro Asp Pro Pro Glu Glu 
                245                 250                 255     


Pro Leu Thr Ser Gln Ala Ser Val Pro Pro His Gln Leu Arg Leu Gly 
            260                 265                 270         


Ser Leu His Pro His Thr Pro Tyr His Ile Arg Val Ala Cys Thr Ser 
        275                 280                 285             


Ser Gln Gly Pro Ser Ser Trp Thr His Trp Leu Pro Val Glu Thr Pro 
    290                 295                 300                 


Glu Gly Val Pro Leu Gly Pro Pro Glu Asn Ile Ser Ala Thr Arg Asn 
305                 310                 315                 320 


Gly Ser Gln Ala Phe Val His Trp Gln Glu Pro Arg Ala Pro Leu Gln 
                325                 330                 335     


Gly Thr Leu Leu Gly Tyr Arg Leu Ala Tyr Gln Gly Gln Asp Thr Pro 
            340                 345                 350         


Glu Val Leu Met Asp Ile Gly Leu Arg Gln Glu Val Thr Leu Glu Leu 
        355                 360                 365             


Gln Gly Asp Gly Ser Val Ser Asn Leu Thr Val Cys Val Ala Ala Tyr 
    370                 375                 380                 


Thr Ala Ala Gly Asp Gly Pro Trp Ser Leu Pro Val Pro Leu Glu Ala 
385                 390                 395                 400 


Trp Arg Pro Gly Gln Ala Gln Pro Val His Gln Leu Val Lys Glu Pro 
                405                 410                 415     


Ser Thr Pro Ala Phe Ser Trp Pro Trp Trp 
            420                 425     


<210>  33
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  Tetrapeptide

<400>  33

Gly Phe Leu Gly 
1               


<210>  34
<211>  4
<212>  PRT
<213>  artificial

<220>
<223>  Tetrapeptide

<400>  34

Ala Leu Ala Leu 
1               


<210>  35
<211>  5
<212>  PRT
<213>  artificial

<220>
<223>  Pentapeptide

<400>  35

Pro Val Gly Val Val 
1               5   


