                         SEQUENCE LISTING

<110>  Regeneron Pharmaceuticals, Inc.
 
<120>  Genetically Modified Major Histocompatibility Complex Mice

<130>  0825A-WO

<150>  61/552,582
<151>  2011-10-28

<150>  61/552,587
<151>  2011-10-28

<150>  61/700,908
<151>  2012-09-14

<160>  8     

<170>  PatentIn version 3.5

<210>  1
<211>  200
<212>  DNA
<213>  Artificial

<220>
<223>  5' homology arm of MHC I targeting construct

<400>  1
ggattcccca tctccacagt ttcacttctg cacctaacct gggtcaggtc cttctgtccg       60

gacactgttg acgcgcagtc agctcttacc cccattgggt ggcgcgatca cccaagaacc      120

aatcagtgtc gccgcggacg ctggatataa agtccacgca gcccgcagaa ctcagaagtc      180

gcgaatcgcc gacaggtgcg                                                  200


<210>  2
<211>  200
<212>  DNA
<213>  Artificial

<220>
<223>  3' homology arm of MHC I targeting construct

<400>  2
gtaaggagag tgtgggtgca gagctggggt cagggaaagc tggagctttc tgcagaccct       60

gagctgctca gggctgagag ctggggtcat gaccctcacc ttcatttctt gtacctgtcc      120

ttcccagagc ctcctccatc cactgtctcc aacatggcga ccgttgctgt tctggttgtc      180

cttggagctg caatagtcac                                                  200


<210>  3
<211>  149
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence of the chimeric human/mouse MHC I locus at the 5' 
       junction of mouse/human sequences

<400>  3
agtgtcgccg cggacgctgg atataaagtc cacgcagccc gcagaactca gaagtcgcga       60

atcgccgaca ggtgcgatgg ccgtcatggc gccccgaacc ctcgtcctgc tactctcggg      120

ggctctggcc ctgacccaga cctgggcgg                                        149


<210>  4
<211>  159
<212>  DNA
<213>  Artificial

<220>
<223>  Sequence of the chimeric human/mouse MHC I locus at the 3' 
       junction of human/mouse sequences

<400>  4
ggtggtgcct tctggacagg agcagagata cacctgccat gtgcagcatg agggtttgcc       60

caagcccctc accctgagat ggggtaagga gagtgtgggt gcagagctgg ggtcagggaa      120

agctggagct ttctgcagac cctgagctgc tcagggctg                             159


<210>  5
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Probe for detection of hygromycin cassette

<400>  5
acgagcgggt tcggcccatt c                                                 21


<210>  6
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Probe for detection of human HLA-A2 alpha2-alpha3 intron

<400>  6
agtccttcag cctccactca ggtcagg                                           27


<210>  7
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Probe for detection of Human HLA-A2 alpha2 exon

<400>  7
taccaccagt acgcctacga cggca                                             25


<210>  8
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Probe for detection of human HLA-A2 alpha2-alpha3 intron

<400>  8
atcctgtacc agagagtg                                                     18


