                              Sequence Listing

<110> GENENTECH, INC. ET AL.

<120> THERAPEUTIC COMBINATIONS AND METHODS OF TREATING MELANOMA

<130> P4777R1-WO

<141> 

<150> US 61/552,893
<151> 2011-10-28

<150> US 61/678,978
<151> 2012-08-02

<160> 22

<210> 1
<211> 10
<212> PRT
<213> Mus musculus

<400> 1
 Gly Tyr Thr Phe Thr Ser Tyr Trp Met Gln
                   5                  10

<210> 2
<211> 17
<212> PRT
<213> Mus musculus

<400> 2
 Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr Ala Gln Lys Phe
   1               5                  10                  15

 Lys Gly
        

<210> 3
<211> 9
<212> PRT
<213> Mus musculus

<400> 3
 Trp Gly Tyr Ala Tyr Asp Ile Asp Asn
                   5                

<210> 4
<211> 16
<212> PRT
<213> Mus musculus

<400> 4
 Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu
   1               5                  10                  15

 Asn
    

<210> 5
<211> 7
<212> PRT
<213> Mus musculus

<400> 5
 Leu Val Ser Lys Leu Asp Ser
                   5        

<210> 6
<211> 9
<212> PRT
<213> Mus musculus

<400> 6
 Trp Gln Gly Thr His Phe Pro Tyr Thr
                   5                

<210> 7
<211> 109
<212> PRT
<213> Artificial sequence

<220>
<223> humanized variable heavy chain

<400> 7
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr
                  50                  55                  60

 Ala Gln Lys Phe Lys Gly Arg Ala Thr Leu Ser Thr Asp Lys Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Ala Tyr Asp Ile
                  95                 100                 105

 Asp Asn Trp Gly
                

<210> 8
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> humanized variable light chain

<400> 8
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Tyr Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys
                 110        

<210> 9
<211> 109
<212> PRT
<213> Artificial sequence

<220>
<223> humanized variable heavy chain.

<400> 9
 Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Gln Trp Val Arg Gln Ala Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Thr Ile Tyr Pro Gly Asp Gly Asp Thr Ser Tyr
                  50                  55                  60

 Ala Gln Lys Phe Lys Gly Arg Val Thr Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Thr Ser Thr Ala Tyr Leu Glu Leu Ser Ser Leu Arg Ser Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Tyr Ala Tyr Asp Ile
                  95                 100                 105

 Asp Asn Trp Gly
                

<210> 10
<211> 442
<212> PRT
<213> Homo sapiens

<400> 10
 Met Gln Pro Pro Pro Ser Leu Cys Gly Arg Ala Leu Val Ala Leu
   1               5                  10                  15

 Val Leu Ala Cys Gly Leu Ser Arg Ile Trp Gly Glu Glu Arg Gly
                  20                  25                  30

 Phe Pro Pro Asp Arg Ala Thr Pro Leu Leu Gln Thr Ala Glu Ile
                  35                  40                  45

 Met Thr Pro Pro Thr Lys Thr Leu Trp Pro Lys Gly Ser Asn Ala
                  50                  55                  60

 Ser Leu Ala Arg Ser Leu Ala Pro Ala Glu Val Pro Lys Gly Asp
                  65                  70                  75

 Arg Thr Ala Gly Ser Pro Pro Arg Thr Ile Ser Pro Pro Pro Cys
                  80                  85                  90

 Gln Gly Pro Ile Glu Ile Lys Glu Thr Phe Lys Tyr Ile Asn Thr
                  95                 100                 105

 Val Val Ser Cys Leu Val Phe Val Leu Gly Ile Ile Gly Asn Ser
                 110                 115                 120

 Thr Leu Leu Arg Ile Ile Tyr Lys Asn Lys Cys Met Arg Asn Gly
                 125                 130                 135

 Pro Asn Ile Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Leu His
                 140                 145                 150

 Ile Val Ile Asp Ile Pro Ile Asn Val Tyr Lys Leu Leu Ala Glu
                 155                 160                 165

 Asp Trp Pro Phe Gly Ala Glu Met Cys Lys Leu Val Pro Phe Ile
                 170                 175                 180

 Gln Lys Ala Ser Val Gly Ile Thr Val Leu Ser Leu Cys Ala Leu
                 185                 190                 195

 Ser Ile Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg Ile Lys
                 200                 205                 210

 Gly Ile Gly Val Pro Lys Trp Thr Ala Val Glu Ile Val Leu Ile
                 215                 220                 225

 Trp Val Val Ser Val Val Leu Ala Val Pro Glu Ala Ile Gly Phe
                 230                 235                 240

 Asp Ile Ile Thr Met Asp Tyr Lys Gly Ser Tyr Leu Arg Ile Cys
                 245                 250                 255

 Leu Leu His Pro Val Gln Lys Thr Ala Phe Met Gln Phe Tyr Lys
                 260                 265                 270

 Thr Ala Lys Asp Trp Trp Leu Phe Ser Phe Tyr Phe Cys Leu Pro
                 275                 280                 285

 Leu Ala Ile Thr Ala Phe Phe Tyr Thr Leu Met Thr Cys Glu Met
                 290                 295                 300

 Leu Arg Lys Lys Ser Gly Met Gln Ile Ala Leu Asn Asp His Leu
                 305                 310                 315

 Lys Gln Arg Arg Glu Val Ala Lys Thr Val Phe Cys Leu Val Leu
                 320                 325                 330

 Val Phe Ala Leu Cys Trp Leu Pro Leu His Leu Ser Arg Ile Leu
                 335                 340                 345

 Lys Leu Thr Leu Tyr Asn Gln Asn Asp Pro Asn Arg Cys Glu Leu
                 350                 355                 360

 Leu Ser Phe Leu Leu Val Leu Asp Tyr Ile Gly Ile Asn Met Ala
                 365                 370                 375

 Ser Leu Asn Ser Cys Ile Asn Pro Ile Ala Leu Tyr Leu Val Ser
                 380                 385                 390

 Lys Arg Phe Lys Asn Cys Phe Lys Ser Cys Leu Cys Cys Trp Cys
                 395                 400                 405

 Gln Ser Phe Glu Glu Lys Gln Ser Leu Glu Glu Lys Gln Ser Cys
                 410                 415                 420

 Leu Lys Phe Lys Ala Asn Asp His Gly Tyr Asp Asn Phe Arg Ser
                 425                 430                 435

 Ser Asn Lys Tyr Ser Ser Ser
                 440        

<210> 11
<211> 19
<212> DNA
<213> Homo sapiens

<400> 11
 agcggattct  catggaaca 19

<210> 12
<211> 18
<212> DNA
<213> Homo sapiens

<400> 12
 ctggtcagcc  aggagctt 18

<210> 13
<211> 24
<212> DNA
<213> Homo sapiens

<400> 13
 tccacaagct gaaggcagac  aagg 24

<210> 14
<211> 22
<212> DNA
<213> Homo sapiens

<400> 14
 tcactgaatt cctgcattaa  cc 22

<210> 15
<211> 24
<212> DNA
<213> Homo sapiens

<400> 15
 gcataagcat gacttaaagc  agtt 24

<210> 16
<211> 33
<212> DNA
<213> Homo sapiens

<400> 16
 aattgctctg tatttggtga gcaaaagatt  caa 33

<210> 17
<211> 24
<212> DNA
<213> Homo sapiens

<400> 17
 cacatcaaag acagcatcta  agaa 24

<210> 18
<211> 25
<212> DNA
<213> Homo sapiens

<400> 18
 caagttggaa aatacagtca  acatt 25

<210> 19
<211> 37
<212> DNA
<213> Homo sapiens

<400> 19
 ttttgttctg tcctggaatt attttagtag  tgtttca 37

<210> 20
<211> 20
<212> DNA
<213> Homo sapiens

<400> 20
 gaagatggtg atgggatttc 20

<210> 21
<211> 19
<212> DNA
<213> Homo sapiens

<400> 21
 gaaggtgaag  gtcggagtc 19

<210> 22
<211> 20
<212> DNA
<213> Homo sapiens

<400> 22
 caagcttccc gttctcagcc 20

