                         SEQUENCE LISTING

<110> Merck Sharp & Dohme Corp.
      Barrett, Stephanie E.      
      Williams, J. Michael
      Kowtoniuk, Robert A.
      
 
<120>  Poly(lysine) Homopolymers for the Delivery of Oligonucleotides

<130>  23153

<150>  US 61/552,028
<150>  2011-10-27

<160>  4     

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (8)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(14)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (15)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  1
cuuuaacaau uccugaaaut t                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(4)
<223>  phosphorotioate linkage

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (6)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(12)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (13)..(14)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (16)..(19)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  2
auuucaggaa uuguuaaagu u                                                 21


<210>  3
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  amino linker

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  inverted deoxy abasic

<220>
<221>  misc_feature
<222>  (1)..(2)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  ribonucleotide unmodified or modified as described for this 
       sequence

<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (7)..(9)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (12)..(12)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (14)..(15)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (19)..(21)
<223>  2' deoxy

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  inverted deoxy abasic

<400>  3
cuagcuggac acgucgauat t                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (5)..(6)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (11)..(13)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  2' fluoro

<220>
<221>  misc_feature
<222>  (18)..(21)
<223>  2' O-methyl

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  phosphorothioate linkage

<400>  4
uaucgacgug uccagcuagu u                                                 21


