                         SEQUENCE LISTING

<110>  Novartis AG
 
<120>  Novel Purine Derivatives and their Use in the Treatment of 
       Disease

<130>  54855-US-PSP

<160>  1     

<170>  PatentIn version 3.3

<210>  1
<211>  615
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Fusion protein used for autophagy assay


<220>
<221>  mCherry
<222>  (1)..(236)

<220>
<221>  GFP
<222>  (241)..(479)

<220>
<221>  LC3A
<222>  (495)..(615)

<400>  1

Met Val Ser Lys Gly Glu Glu Asp Asn Met Ala Ile Ile Lys Glu Phe 
1               5                   10                  15      


Met Arg Phe Lys Val His Met Glu Gly Ser Val Asn Gly His Glu Phe 
            20                  25                  30          


Glu Ile Glu Gly Glu Gly Glu Gly Arg Pro Tyr Glu Gly Thr Gln Thr 
        35                  40                  45              


Ala Lys Leu Lys Val Thr Lys Gly Gly Pro Leu Pro Phe Ala Trp Asp 
    50                  55                  60                  


Ile Leu Ser Pro Gln Phe Met Tyr Gly Ser Lys Ala Tyr Val Lys His 
65                  70                  75                  80  


Pro Ala Asp Ile Pro Asp Tyr Leu Lys Leu Ser Phe Pro Glu Gly Phe 
                85                  90                  95      


Lys Trp Glu Arg Val Met Asn Phe Glu Asp Gly Gly Val Val Thr Val 
            100                 105                 110         


Thr Gln Asp Ser Ser Leu Gln Asp Gly Glu Phe Ile Tyr Lys Val Lys 
        115                 120                 125             


Leu Arg Gly Thr Asn Phe Pro Ser Asp Gly Pro Val Met Gln Lys Lys 
    130                 135                 140                 


Thr Met Gly Trp Glu Ala Ser Ser Glu Arg Met Tyr Pro Glu Asp Gly 
145                 150                 155                 160 


Ala Leu Lys Gly Glu Ile Lys Gln Arg Leu Lys Leu Lys Asp Gly Gly 
                165                 170                 175     


His Tyr Asp Ala Glu Val Lys Thr Thr Tyr Lys Ala Lys Lys Pro Val 
            180                 185                 190         


Gln Leu Pro Gly Ala Tyr Asn Val Asn Ile Lys Leu Asp Ile Thr Ser 
        195                 200                 205             


His Asn Glu Asp Tyr Thr Ile Val Glu Gln Tyr Glu Arg Ala Glu Gly 
    210                 215                 220                 


Arg His Ser Thr Gly Gly Met Asp Glu Leu Tyr Lys Pro Val Ala Thr 
225                 230                 235                 240 


Met Val Ser Lys Gly Glu Glu Leu Phe Thr Gly Val Val Pro Ile Leu 
                245                 250                 255     


Val Glu Leu Asp Gly Asp Val Asn Gly His Lys Phe Ser Val Ser Gly 
            260                 265                 270         


Glu Gly Glu Gly Asp Ala Thr Tyr Gly Lys Leu Thr Leu Lys Phe Ile 
        275                 280                 285             


Cys Thr Thr Gly Lys Leu Pro Val Pro Trp Pro Thr Leu Val Thr Thr 
    290                 295                 300                 


Leu Thr Tyr Gly Val Gln Cys Phe Ser Arg Tyr Pro Asp His Met Lys 
305                 310                 315                 320 


Gln His Asp Phe Phe Lys Ser Ala Met Pro Glu Gly Tyr Val Gln Glu 
                325                 330                 335     


Arg Thr Ile Phe Phe Lys Asp Asp Gly Asn Tyr Lys Thr Arg Ala Glu 
            340                 345                 350         


Val Lys Phe Glu Gly Asp Thr Leu Val Asn Arg Ile Glu Leu Lys Gly 
        355                 360                 365             


Ile Asp Phe Lys Glu Asp Gly Asn Ile Leu Gly His Lys Leu Glu Tyr 
    370                 375                 380                 


Asn Tyr Asn Ser His Asn Val Tyr Ile Met Ala Asp Lys Gln Lys Asn 
385                 390                 395                 400 


Gly Ile Lys Val Asn Phe Lys Ile Arg His Asn Ile Glu Asp Gly Ser 
                405                 410                 415     


Val Gln Leu Ala Asp His Tyr Gln Gln Asn Thr Pro Ile Gly Asp Gly 
            420                 425                 430         


Pro Val Leu Leu Pro Asp Asn His Tyr Leu Ser Thr Gln Ser Ala Leu 
        435                 440                 445             


Ser Lys Asp Pro Asn Glu Lys Arg Asp His Met Val Leu Leu Glu Phe 
    450                 455                 460                 


Val Thr Ala Ala Gly Ile Thr Leu Gly Met Asp Glu Leu Tyr Lys Ser 
465                 470                 475                 480 


Gly Leu Arg Ser Arg Ala Gln Ala Ser Asn Ser Ala Val Asp Met Pro 
                485                 490                 495     


Ser Asp Arg Pro Phe Lys Gln Arg Arg Ser Phe Ala Asp Arg Cys Lys 
            500                 505                 510         


Glu Val Gln Gln Ile Arg Asp Gln His Pro Ser Lys Ile Pro Val Ile 
        515                 520                 525             


Ile Glu Arg Tyr Lys Gly Glu Lys Gln Leu Pro Val Leu Asp Lys Thr 
    530                 535                 540                 


Lys Phe Leu Val Pro Asp His Val Asn Met Ser Glu Leu Val Lys Ile 
545                 550                 555                 560 


Ile Arg Arg Arg Leu Gln Leu Asn Pro Thr Gln Ala Phe Phe Leu Leu 
                565                 570                 575     


Val Asn Gln His Ser Met Val Ser Val Ser Thr Pro Ile Ala Asp Ile 
            580                 585                 590         


Tyr Glu Gln Glu Lys Asp Glu Asp Gly Phe Leu Tyr Met Val Tyr Ala 
        595                 600                 605             


Ser Gln Glu Thr Phe Gly Phe 
    610                 615 


