                               SEQUENCE LISTING

<110> FOUNDATION MEDICINE, INC.
 
<120> NOVEL ALK AND NTRK1 FUSION MOLECULES AND USES THEREOF

<130> F2036-7031WO

<140> PCT/US2012/061211
<141> 2012-10-19

<150> 61/550,327
<151> 2011-10-21

<160> 13    

<170> PatentIn version 3.5

<210> 1
<211> 200
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> modified_base
<222> (16)..(185)
<223> a, c, t, g, unknown or other

<400> 1
atcgcaccag cgtgtnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn       60

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      120

nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn      180

nnnnncactg cggctcctca                                                  200


<210> 2

<400> 2
000


<210> 3

<400> 3
000


<210> 4

<400> 4
000


<210> 5
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 5
gttttggctt ggcctgggct gccctaatca ccaccccacc caattcacag tgtccaagca       60

gagaagcaat caa                                                          73


<210> 6
<211> 4887
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(4884)

<400> 6
atg gca cag agc aag agg cac gtg tac agc cgg acg ccc agc ggc agc         48
Met Ala Gln Ser Lys Arg His Val Tyr Ser Arg Thr Pro Ser Gly Ser           
1               5                   10                  15                

agg atg agt gcg gag gca agc gcc cgg cct ctg cgg gtg ggc tcc cgt         96
Arg Met Ser Ala Glu Ala Ser Ala Arg Pro Leu Arg Val Gly Ser Arg           
            20                  25                  30                    

gta gag gtg att gga aaa ggc cac cga ggc act gtg gcc tat gtt gga        144
Val Glu Val Ile Gly Lys Gly His Arg Gly Thr Val Ala Tyr Val Gly           
        35                  40                  45                        

gcc aca ctg ttt gcc act ggc aaa tgg gta ggc gtg att ctg gat gaa        192
Ala Thr Leu Phe Ala Thr Gly Lys Trp Val Gly Val Ile Leu Asp Glu           
    50                  55                  60                            

gca aag ggc aaa aat gat gga act gtt caa ggc agg aag tac ttc act        240
Ala Lys Gly Lys Asn Asp Gly Thr Val Gln Gly Arg Lys Tyr Phe Thr           
65                  70                  75                  80            

tgt gat gaa ggg cat ggc atc ttt gtg cgc cag tcc cag atc cag gta        288
Cys Asp Glu Gly His Gly Ile Phe Val Arg Gln Ser Gln Ile Gln Val           
                85                  90                  95                

ttt gaa gat gga gca gat act act tcc cca gag aca cct gat tct tct        336
Phe Glu Asp Gly Ala Asp Thr Thr Ser Pro Glu Thr Pro Asp Ser Ser           
            100                 105                 110                   

gct tca aaa gtc ctc aaa aga gag gga act gat aca act gca aag act        384
Ala Ser Lys Val Leu Lys Arg Glu Gly Thr Asp Thr Thr Ala Lys Thr           
        115                 120                 125                       

agc aaa ctg cgg gga ctg aag cct aag aag gca ccg aca gcc cga aag        432
Ser Lys Leu Arg Gly Leu Lys Pro Lys Lys Ala Pro Thr Ala Arg Lys           
    130                 135                 140                           

acc aca act cgg cga ccc aag ccc acg cgc cca gcc agt act ggg gtg        480
Thr Thr Thr Arg Arg Pro Lys Pro Thr Arg Pro Ala Ser Thr Gly Val           
145                 150                 155                 160           

gct ggg gcc agt agc tcc ctg ggc ccc tct ggc tca gcg tca gca ggt        528
Ala Gly Ala Ser Ser Ser Leu Gly Pro Ser Gly Ser Ala Ser Ala Gly           
                165                 170                 175               

gag ctg agc agc agt gag ccc agc acc ccg gct cag act ccg ctg gca        576
Glu Leu Ser Ser Ser Glu Pro Ser Thr Pro Ala Gln Thr Pro Leu Ala           
            180                 185                 190                   

gca ccc atc atc ccc acg ccg gtc ctc acc tct cct gga gca gtc ccc        624
Ala Pro Ile Ile Pro Thr Pro Val Leu Thr Ser Pro Gly Ala Val Pro           
        195                 200                 205                       

ccg ctt cct tcc cca tcc aag gag gag gag gga cta agg gct cag gtg        672
Pro Leu Pro Ser Pro Ser Lys Glu Glu Glu Gly Leu Arg Ala Gln Val           
    210                 215                 220                           

cgg gac ctg gag gag aaa cta gag acc ctg aga ctg aaa cgg gca gaa        720
Arg Asp Leu Glu Glu Lys Leu Glu Thr Leu Arg Leu Lys Arg Ala Glu           
225                 230                 235                 240           

gac aaa gca aag cta aaa gag ctg gag aaa cac aaa atc cag ctg gag        768
Asp Lys Ala Lys Leu Lys Glu Leu Glu Lys His Lys Ile Gln Leu Glu           
                245                 250                 255               

cag gtg cag gaa tgg aag agc aaa atg cag gag cag cag gcc gac ctg        816
Gln Val Gln Glu Trp Lys Ser Lys Met Gln Glu Gln Gln Ala Asp Leu           
            260                 265                 270                   

cag cgg cgc ctc aag gag gcg aga aag gaa gcc aag gag gcg ctg gag        864
Gln Arg Arg Leu Lys Glu Ala Arg Lys Glu Ala Lys Glu Ala Leu Glu           
        275                 280                 285                       

gca aag gaa cgc tat atg gag gag atg gct gat act gct gat gcc att        912
Ala Lys Glu Arg Tyr Met Glu Glu Met Ala Asp Thr Ala Asp Ala Ile           
    290                 295                 300                           

gag atg gcc act ttg gac aag gag atg gct gaa gag cgg gct gag tcc        960
Glu Met Ala Thr Leu Asp Lys Glu Met Ala Glu Glu Arg Ala Glu Ser           
305                 310                 315                 320           

ctg cag cag gag gtg gag gca ctg aag gag cgg gtg gac gag ctc act       1008
Leu Gln Gln Glu Val Glu Ala Leu Lys Glu Arg Val Asp Glu Leu Thr           
                325                 330                 335               

act gac tta gag atc ctc aag gct gag att gaa gag aag ggc tca gat       1056
Thr Asp Leu Glu Ile Leu Lys Ala Glu Ile Glu Glu Lys Gly Ser Asp           
            340                 345                 350                   

ggc gct gca tcc agt tat cag ctc aag cag ctt gag gag cag aat gcc       1104
Gly Ala Ala Ser Ser Tyr Gln Leu Lys Gln Leu Glu Glu Gln Asn Ala           
        355                 360                 365                       

cgc ctg aag gat gcc ctg gtg agg atg cgg gat ctt tct tcc tca gag       1152
Arg Leu Lys Asp Ala Leu Val Arg Met Arg Asp Leu Ser Ser Ser Glu           
    370                 375                 380                           

aag cag gag cat gtg aag ctc cag aag ctc atg gaa aag aag aac caa       1200
Lys Gln Glu His Val Lys Leu Gln Lys Leu Met Glu Lys Lys Asn Gln           
385                 390                 395                 400           

gag ctg gaa gtt gtg agg caa cag cgg gag cgt ctg cag gag gag cta       1248
Glu Leu Glu Val Val Arg Gln Gln Arg Glu Arg Leu Gln Glu Glu Leu           
                405                 410                 415               

agc cag gca gag agc acc att gat gag ctc aag gag cag gtg gat gct       1296
Ser Gln Ala Glu Ser Thr Ile Asp Glu Leu Lys Glu Gln Val Asp Ala           
            420                 425                 430                   

gct ctg ggt gct gag gag atg gtg gag atg ctg aca gat cgg aac ctg       1344
Ala Leu Gly Ala Glu Glu Met Val Glu Met Leu Thr Asp Arg Asn Leu           
        435                 440                 445                       

aat ctg gaa gag aaa gtg cgc gag ttg agg gag act gtg gga gac ttg       1392
Asn Leu Glu Glu Lys Val Arg Glu Leu Arg Glu Thr Val Gly Asp Leu           
    450                 455                 460                           

gaa gcg atg aat gag atg aac gat gag ctg cag gag aat gca cgt gag       1440
Glu Ala Met Asn Glu Met Asn Asp Glu Leu Gln Glu Asn Ala Arg Glu           
465                 470                 475                 480           

aca gaa ctg gag ctg cgg gag cag ctg gac atg gca ggc gcg cgg gtt       1488
Thr Glu Leu Glu Leu Arg Glu Gln Leu Asp Met Ala Gly Ala Arg Val           
                485                 490                 495               

cgt gag gcc cag aag cgt gtg gag gca gcc cag gag acg gtt gca gac       1536
Arg Glu Ala Gln Lys Arg Val Glu Ala Ala Gln Glu Thr Val Ala Asp           
            500                 505                 510                   

tac cag cag acc atc aag aag tac cgc cag ctg acc gcc cat cta cag       1584
Tyr Gln Gln Thr Ile Lys Lys Tyr Arg Gln Leu Thr Ala His Leu Gln           
        515                 520                 525                       

gat gtg aat cgg gaa ctg aca aac cag cag gaa gca tct gtg gag agg       1632
Asp Val Asn Arg Glu Leu Thr Asn Gln Gln Glu Ala Ser Val Glu Arg           
    530                 535                 540                           

caa cag cag cca cct cca gag acc ttt gac ttc aaa atc aag ttt gct       1680
Gln Gln Gln Pro Pro Pro Glu Thr Phe Asp Phe Lys Ile Lys Phe Ala           
545                 550                 555                 560           

gag act aag gcc cat gcc aag gca att gag atg gaa ttg agg cag atg       1728
Glu Thr Lys Ala His Ala Lys Ala Ile Glu Met Glu Leu Arg Gln Met           
                565                 570                 575               

gag gtg gcc cag gcc aat cga cac atg tcc ctg ctg aca gcc ttc atg       1776
Glu Val Ala Gln Ala Asn Arg His Met Ser Leu Leu Thr Ala Phe Met           
            580                 585                 590                   

cct gac agc ttc ctt cgg cca ggt ggg gac cat gac tgc gtt ctg gtg       1824
Pro Asp Ser Phe Leu Arg Pro Gly Gly Asp His Asp Cys Val Leu Val           
        595                 600                 605                       

ctg ttg ctc atg cct cgt ctc att tgc aag gca gag ctg atc cgg aag       1872
Leu Leu Leu Met Pro Arg Leu Ile Cys Lys Ala Glu Leu Ile Arg Lys           
    610                 615                 620                           

cag gcc cag gag aag ttt gaa cta agt gag aac tgt tca gag cgg cct       1920
Gln Ala Gln Glu Lys Phe Glu Leu Ser Glu Asn Cys Ser Glu Arg Pro           
625                 630                 635                 640           

ggg ctg cga gga gct gct ggg gag caa ctc agc ttt gct gct gga ctg       1968
Gly Leu Arg Gly Ala Ala Gly Glu Gln Leu Ser Phe Ala Ala Gly Leu           
                645                 650                 655               

gtg tac tcg ctg agc ctg ctg cag gcc acg cta cac cgc tat gag cat       2016
Val Tyr Ser Leu Ser Leu Leu Gln Ala Thr Leu His Arg Tyr Glu His           
            660                 665                 670                   

gcc ctc tct cag tgc agt gtg gat gtg tat aag aaa gtg ggc agc ctg       2064
Ala Leu Ser Gln Cys Ser Val Asp Val Tyr Lys Lys Val Gly Ser Leu           
        675                 680                 685                       

tac cct gag atg agt gcc cat gag cgc tcc ttg gat ttc ctc att gaa       2112
Tyr Pro Glu Met Ser Ala His Glu Arg Ser Leu Asp Phe Leu Ile Glu           
    690                 695                 700                           

ctg ctg cac aag gat cag ctg gat gag act gtc aat gtg gag cct ctc       2160
Leu Leu His Lys Asp Gln Leu Asp Glu Thr Val Asn Val Glu Pro Leu           
705                 710                 715                 720           

acc aag gcc atc aag tac tat cag cat ctg tac agc atc cac ctt gcc       2208
Thr Lys Ala Ile Lys Tyr Tyr Gln His Leu Tyr Ser Ile His Leu Ala           
                725                 730                 735               

gaa cag cct gag gac tgt act atg cag ctg gct gac cac att aag ttc       2256
Glu Gln Pro Glu Asp Cys Thr Met Gln Leu Ala Asp His Ile Lys Phe           
            740                 745                 750                   

acg cag agt gct ctg gac tgc atg agt gtg gag gta gga cgg ctg cgt       2304
Thr Gln Ser Ala Leu Asp Cys Met Ser Val Glu Val Gly Arg Leu Arg           
        755                 760                 765                       

gcc ttc ttg cag ggt ggg cag gag gct aca gat att gcc ctc ctg ctc       2352
Ala Phe Leu Gln Gly Gly Gln Glu Ala Thr Asp Ile Ala Leu Leu Leu           
    770                 775                 780                           

cgg gat ctg gaa act tca tgc agt gac atc cgc cag ttc tgc aag aag       2400
Arg Asp Leu Glu Thr Ser Cys Ser Asp Ile Arg Gln Phe Cys Lys Lys           
785                 790                 795                 800           

atc cga agg cga atg cca ggg aca gat gct cct ggg atc cca gct gca       2448
Ile Arg Arg Arg Met Pro Gly Thr Asp Ala Pro Gly Ile Pro Ala Ala           
                805                 810                 815               

ctg gcc ttt gga cca cag gta tct gac acg ctc cta gac tgc agg aaa       2496
Leu Ala Phe Gly Pro Gln Val Ser Asp Thr Leu Leu Asp Cys Arg Lys           
            820                 825                 830                   

cac ttg acg tgg gtc gtg gct gtg ctg cag gag gtg gca gct gct gct       2544
His Leu Thr Trp Val Val Ala Val Leu Gln Glu Val Ala Ala Ala Ala           
        835                 840                 845                       

gcc cag ctc att gcc cca ctg gca gag aat gag ggg cta ctt gtg gct       2592
Ala Gln Leu Ile Ala Pro Leu Ala Glu Asn Glu Gly Leu Leu Val Ala           
    850                 855                 860                           

gct ctg gag gaa ctg gct ttc aaa gca agc gag cag atc tat ggg acc       2640
Ala Leu Glu Glu Leu Ala Phe Lys Ala Ser Glu Gln Ile Tyr Gly Thr           
865                 870                 875                 880           

ccc tcc agc agc ccc tat gag tgt ctg cgc cag tca tgc aac atc ctc       2688
Pro Ser Ser Ser Pro Tyr Glu Cys Leu Arg Gln Ser Cys Asn Ile Leu           
                885                 890                 895               

atc agt acc atg aac aag ctg gcc aca gcc atg cag gag ggg gag tat       2736
Ile Ser Thr Met Asn Lys Leu Ala Thr Ala Met Gln Glu Gly Glu Tyr           
            900                 905                 910                   

gat gca gag cgg ccc ccc agc aag cct cca ccg gtt gaa ctg cgg gct       2784
Asp Ala Glu Arg Pro Pro Ser Lys Pro Pro Pro Val Glu Leu Arg Ala           
        915                 920                 925                       

gct gcc ctt cgt gca gag atc aca gat gct gaa ggc ctg ggt ttg aag       2832
Ala Ala Leu Arg Ala Glu Ile Thr Asp Ala Glu Gly Leu Gly Leu Lys           
    930                 935                 940                           

ctc gaa gat cga gag aca gtt att aag gag ttg aag aag tca ctc aag       2880
Leu Glu Asp Arg Glu Thr Val Ile Lys Glu Leu Lys Lys Ser Leu Lys           
945                 950                 955                 960           

att aag gga gag gag cta agt gag gcc aat gtg cgg ctg agc ctc ctg       2928
Ile Lys Gly Glu Glu Leu Ser Glu Ala Asn Val Arg Leu Ser Leu Leu           
                965                 970                 975               

gag aag aag ttg gac agt gct gcc aag gat gca gat gag cgc atc gag       2976
Glu Lys Lys Leu Asp Ser Ala Ala Lys Asp Ala Asp Glu Arg Ile Glu           
            980                 985                 990                   

aaa gtc cag act cgg ctg gag gag  acc cag gca ctg ctg  cga aag aag     3024
Lys Val Gln Thr Arg Leu Glu Glu  Thr Gln Ala Leu Leu  Arg Lys Lys         
        995                 1000                 1005                     

gag aaa  gag ttt gag gag aca  atg gat gca ctc cag  gct gac atc        3069
Glu Lys  Glu Phe Glu Glu Thr  Met Asp Ala Leu Gln  Ala Asp Ile            
    1010                 1015                 1020                        

gac cag  ctg gag gca gag aag  gca gaa cta aag cag  cgt ctg aac        3114
Asp Gln  Leu Glu Ala Glu Lys  Ala Glu Leu Lys Gln  Arg Leu Asn            
    1025                 1030                 1035                        

agc cag  tcc aaa cgc acg att  gag gga ctc cgg ggc  cct cct cct        3159
Ser Gln  Ser Lys Arg Thr Ile  Glu Gly Leu Arg Gly  Pro Pro Pro            
    1040                 1045                 1050                        

tca ggc  att gct act ctg gtc  tct ggc att gct ggt  gtg tac cgc        3204
Ser Gly  Ile Ala Thr Leu Val  Ser Gly Ile Ala Gly  Val Tyr Arg            
    1055                 1060                 1065                        

cgg aag  cac cag gag ctg caa  gcc atg cag atg gag  ctg cag agc        3249
Arg Lys  His Gln Glu Leu Gln  Ala Met Gln Met Glu  Leu Gln Ser            
    1070                 1075                 1080                        

cct gag  tac aag ctg agc aag  ctc cgc acc tcg acc  atc atg acc        3294
Pro Glu  Tyr Lys Leu Ser Lys  Leu Arg Thr Ser Thr  Ile Met Thr            
    1085                 1090                 1095                        

gac tac  aac ccc aac tac tgc  ttt gct ggc aag acc  tcc tcc atc        3339
Asp Tyr  Asn Pro Asn Tyr Cys  Phe Ala Gly Lys Thr  Ser Ser Ile            
    1100                 1105                 1110                        

agt gac  ctg aag gag gtg ccg  cgg aaa aac atc acc  ctc att cgg        3384
Ser Asp  Leu Lys Glu Val Pro  Arg Lys Asn Ile Thr  Leu Ile Arg            
    1115                 1120                 1125                        

ggt ctg  ggc cat ggc gcc ttt  ggg gag gtg tat gaa  ggc cag gtg        3429
Gly Leu  Gly His Gly Ala Phe  Gly Glu Val Tyr Glu  Gly Gln Val            
    1130                 1135                 1140                        

tcc gga  atg ccc aac gac cca  agc ccc ctg caa gtg  gct gtg aag        3474
Ser Gly  Met Pro Asn Asp Pro  Ser Pro Leu Gln Val  Ala Val Lys            
    1145                 1150                 1155                        

acg ctg  cct gaa gtg tgc tct  gaa cag gac gaa ctg  gat ttc ctc        3519
Thr Leu  Pro Glu Val Cys Ser  Glu Gln Asp Glu Leu  Asp Phe Leu            
    1160                 1165                 1170                        

atg gaa  gcc ctg atc atc agc  aaa ttc aac cac cag  aac att gtt        3564
Met Glu  Ala Leu Ile Ile Ser  Lys Phe Asn His Gln  Asn Ile Val            
    1175                 1180                 1185                        

cgc tgc  att ggg gtg agc ctg  caa tcc ctg ccc cgg  ttc atc ctg        3609
Arg Cys  Ile Gly Val Ser Leu  Gln Ser Leu Pro Arg  Phe Ile Leu            
    1190                 1195                 1200                        

ctg gag  ctc atg gcg ggg gga  gac ctc aag tcc ttc  ctc cga gag        3654
Leu Glu  Leu Met Ala Gly Gly  Asp Leu Lys Ser Phe  Leu Arg Glu            
    1205                 1210                 1215                        

acc cgc  cct cgc ccg agc cag  ccc tcc tcc ctg gcc  atg ctg gac        3699
Thr Arg  Pro Arg Pro Ser Gln  Pro Ser Ser Leu Ala  Met Leu Asp            
    1220                 1225                 1230                        

ctt ctg  cac gtg gct cgg gac  att gcc tgt ggc tgt  cag tat ttg        3744
Leu Leu  His Val Ala Arg Asp  Ile Ala Cys Gly Cys  Gln Tyr Leu            
    1235                 1240                 1245                        

gag gaa  aac cac ttc atc cac  cga gac att gct gcc  aga aac tgc        3789
Glu Glu  Asn His Phe Ile His  Arg Asp Ile Ala Ala  Arg Asn Cys            
    1250                 1255                 1260                        

ctc ttg  acc tgt cca ggc cct  gga aga gtg gcc aag  att gga gac        3834
Leu Leu  Thr Cys Pro Gly Pro  Gly Arg Val Ala Lys  Ile Gly Asp            
    1265                 1270                 1275                        

ttc ggg  atg gcc cga gac atc  tac agg gcg agc tac  tat aga aag        3879
Phe Gly  Met Ala Arg Asp Ile  Tyr Arg Ala Ser Tyr  Tyr Arg Lys            
    1280                 1285                 1290                        

gga ggc  tgt gcc atg ctg cca  gtt aag tgg atg ccc  cca gag gcc        3924
Gly Gly  Cys Ala Met Leu Pro  Val Lys Trp Met Pro  Pro Glu Ala            
    1295                 1300                 1305                        

ttc atg  gaa gga ata ttc act  tct aaa aca gac aca  tgg tcc ttt        3969
Phe Met  Glu Gly Ile Phe Thr  Ser Lys Thr Asp Thr  Trp Ser Phe            
    1310                 1315                 1320                        

gga gtg  ctg cta tgg gaa atc  ttt tct ctt gga tat  atg cca tac        4014
Gly Val  Leu Leu Trp Glu Ile  Phe Ser Leu Gly Tyr  Met Pro Tyr            
    1325                 1330                 1335                        

ccc agc  aaa agc aac cag gaa  gtt ctg gag ttt gtc  acc agt gga        4059
Pro Ser  Lys Ser Asn Gln Glu  Val Leu Glu Phe Val  Thr Ser Gly            
    1340                 1345                 1350                        

ggc cgg  atg gac cca ccc aag  aac tgc cct ggg cct  gta tac cgg        4104
Gly Arg  Met Asp Pro Pro Lys  Asn Cys Pro Gly Pro  Val Tyr Arg            
    1355                 1360                 1365                        

ata atg  act cag tgc tgg caa  cat cag cct gaa gac  agg ccc aac        4149
Ile Met  Thr Gln Cys Trp Gln  His Gln Pro Glu Asp  Arg Pro Asn            
    1370                 1375                 1380                        

ttt gcc  atc att ttg gag agg  att gaa tac tgc acc  cag gac ccg        4194
Phe Ala  Ile Ile Leu Glu Arg  Ile Glu Tyr Cys Thr  Gln Asp Pro            
    1385                 1390                 1395                        

gat gta  atc aac acc gct ttg  ccg ata gaa tat ggt  cca ctt gtg        4239
Asp Val  Ile Asn Thr Ala Leu  Pro Ile Glu Tyr Gly  Pro Leu Val            
    1400                 1405                 1410                        

gaa gag  gaa gag aaa gtg cct  gtg agg ccc aag gac  cct gag ggg        4284
Glu Glu  Glu Glu Lys Val Pro  Val Arg Pro Lys Asp  Pro Glu Gly            
    1415                 1420                 1425                        

gtt cct  cct ctc ctg gtc tct  caa cag gca aaa cgg  gag gag gag        4329
Val Pro  Pro Leu Leu Val Ser  Gln Gln Ala Lys Arg  Glu Glu Glu            
    1430                 1435                 1440                        

cgc agc  cca gct gcc cca cca  cct ctg cct acc acc  tcc tct ggc        4374
Arg Ser  Pro Ala Ala Pro Pro  Pro Leu Pro Thr Thr  Ser Ser Gly            
    1445                 1450                 1455                        

aag gct  gca aag aaa ccc aca  gct gca gag atc tct  gtt cga gtc        4419
Lys Ala  Ala Lys Lys Pro Thr  Ala Ala Glu Ile Ser  Val Arg Val            
    1460                 1465                 1470                        

cct aga  ggg ccg gcc gtg gaa  ggg gga cac gtg aat  atg gca ttc        4464
Pro Arg  Gly Pro Ala Val Glu  Gly Gly His Val Asn  Met Ala Phe            
    1475                 1480                 1485                        

tct cag  tcc aac cct cct tcg  gag ttg cac aag gtc  cac gga tcc        4509
Ser Gln  Ser Asn Pro Pro Ser  Glu Leu His Lys Val  His Gly Ser            
    1490                 1495                 1500                        

aga aac  aag ccc acc agc ttg  tgg aac cca acg tac  ggc tcc tgg        4554
Arg Asn  Lys Pro Thr Ser Leu  Trp Asn Pro Thr Tyr  Gly Ser Trp            
    1505                 1510                 1515                        

ttt aca  gag aaa ccc acc aaa  aag aat aat cct ata  gca aag aag        4599
Phe Thr  Glu Lys Pro Thr Lys  Lys Asn Asn Pro Ile  Ala Lys Lys            
    1520                 1525                 1530                        

gag cca  cac gac agg ggt aac  ctg ggg ctg gag gga  agc tgt act        4644
Glu Pro  His Asp Arg Gly Asn  Leu Gly Leu Glu Gly  Ser Cys Thr            
    1535                 1540                 1545                        

gtc cca  cct aac gtt gca act  ggg aga ctt ccg ggg  gcc tca ctg        4689
Val Pro  Pro Asn Val Ala Thr  Gly Arg Leu Pro Gly  Ala Ser Leu            
    1550                 1555                 1560                        

ctc cta  gag ccc tct tcg ctg  act gcc aat atg aag  gag gta cct        4734
Leu Leu  Glu Pro Ser Ser Leu  Thr Ala Asn Met Lys  Glu Val Pro            
    1565                 1570                 1575                        

ctg ttc  agg cta cgt cac ttc  cct tgt ggg aat gtc  aat tac ggc        4779
Leu Phe  Arg Leu Arg His Phe  Pro Cys Gly Asn Val  Asn Tyr Gly            
    1580                 1585                 1590                        

tac cag  caa cag ggc ttg ccc  tta gaa gcc gct act  gcc cct gga        4824
Tyr Gln  Gln Gln Gly Leu Pro  Leu Glu Ala Ala Thr  Ala Pro Gly            
    1595                 1600                 1605                        

gct ggt  cat tac gag gat acc  att ctg aaa agc aag  aat agc atg        4869
Ala Gly  His Tyr Glu Asp Thr  Ile Leu Lys Ser Lys  Asn Ser Met            
    1610                 1615                 1620                        

aac cag  cct ggg ccc tga                                              4887
Asn Gln  Pro Gly Pro                                                      
    1625                                                                  


<210> 7
<211> 1628
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 7
Met Ala Gln Ser Lys Arg His Val Tyr Ser Arg Thr Pro Ser Gly Ser 
1               5                   10                  15      


Arg Met Ser Ala Glu Ala Ser Ala Arg Pro Leu Arg Val Gly Ser Arg 
            20                  25                  30          


Val Glu Val Ile Gly Lys Gly His Arg Gly Thr Val Ala Tyr Val Gly 
        35                  40                  45              


Ala Thr Leu Phe Ala Thr Gly Lys Trp Val Gly Val Ile Leu Asp Glu 
    50                  55                  60                  


Ala Lys Gly Lys Asn Asp Gly Thr Val Gln Gly Arg Lys Tyr Phe Thr 
65                  70                  75                  80  


Cys Asp Glu Gly His Gly Ile Phe Val Arg Gln Ser Gln Ile Gln Val 
                85                  90                  95      


Phe Glu Asp Gly Ala Asp Thr Thr Ser Pro Glu Thr Pro Asp Ser Ser 
            100                 105                 110         


Ala Ser Lys Val Leu Lys Arg Glu Gly Thr Asp Thr Thr Ala Lys Thr 
        115                 120                 125             


Ser Lys Leu Arg Gly Leu Lys Pro Lys Lys Ala Pro Thr Ala Arg Lys 
    130                 135                 140                 


Thr Thr Thr Arg Arg Pro Lys Pro Thr Arg Pro Ala Ser Thr Gly Val 
145                 150                 155                 160 


Ala Gly Ala Ser Ser Ser Leu Gly Pro Ser Gly Ser Ala Ser Ala Gly 
                165                 170                 175     


Glu Leu Ser Ser Ser Glu Pro Ser Thr Pro Ala Gln Thr Pro Leu Ala 
            180                 185                 190         


Ala Pro Ile Ile Pro Thr Pro Val Leu Thr Ser Pro Gly Ala Val Pro 
        195                 200                 205             


Pro Leu Pro Ser Pro Ser Lys Glu Glu Glu Gly Leu Arg Ala Gln Val 
    210                 215                 220                 


Arg Asp Leu Glu Glu Lys Leu Glu Thr Leu Arg Leu Lys Arg Ala Glu 
225                 230                 235                 240 


Asp Lys Ala Lys Leu Lys Glu Leu Glu Lys His Lys Ile Gln Leu Glu 
                245                 250                 255     


Gln Val Gln Glu Trp Lys Ser Lys Met Gln Glu Gln Gln Ala Asp Leu 
            260                 265                 270         


Gln Arg Arg Leu Lys Glu Ala Arg Lys Glu Ala Lys Glu Ala Leu Glu 
        275                 280                 285             


Ala Lys Glu Arg Tyr Met Glu Glu Met Ala Asp Thr Ala Asp Ala Ile 
    290                 295                 300                 


Glu Met Ala Thr Leu Asp Lys Glu Met Ala Glu Glu Arg Ala Glu Ser 
305                 310                 315                 320 


Leu Gln Gln Glu Val Glu Ala Leu Lys Glu Arg Val Asp Glu Leu Thr 
                325                 330                 335     


Thr Asp Leu Glu Ile Leu Lys Ala Glu Ile Glu Glu Lys Gly Ser Asp 
            340                 345                 350         


Gly Ala Ala Ser Ser Tyr Gln Leu Lys Gln Leu Glu Glu Gln Asn Ala 
        355                 360                 365             


Arg Leu Lys Asp Ala Leu Val Arg Met Arg Asp Leu Ser Ser Ser Glu 
    370                 375                 380                 


Lys Gln Glu His Val Lys Leu Gln Lys Leu Met Glu Lys Lys Asn Gln 
385                 390                 395                 400 


Glu Leu Glu Val Val Arg Gln Gln Arg Glu Arg Leu Gln Glu Glu Leu 
                405                 410                 415     


Ser Gln Ala Glu Ser Thr Ile Asp Glu Leu Lys Glu Gln Val Asp Ala 
            420                 425                 430         


Ala Leu Gly Ala Glu Glu Met Val Glu Met Leu Thr Asp Arg Asn Leu 
        435                 440                 445             


Asn Leu Glu Glu Lys Val Arg Glu Leu Arg Glu Thr Val Gly Asp Leu 
    450                 455                 460                 


Glu Ala Met Asn Glu Met Asn Asp Glu Leu Gln Glu Asn Ala Arg Glu 
465                 470                 475                 480 


Thr Glu Leu Glu Leu Arg Glu Gln Leu Asp Met Ala Gly Ala Arg Val 
                485                 490                 495     


Arg Glu Ala Gln Lys Arg Val Glu Ala Ala Gln Glu Thr Val Ala Asp 
            500                 505                 510         


Tyr Gln Gln Thr Ile Lys Lys Tyr Arg Gln Leu Thr Ala His Leu Gln 
        515                 520                 525             


Asp Val Asn Arg Glu Leu Thr Asn Gln Gln Glu Ala Ser Val Glu Arg 
    530                 535                 540                 


Gln Gln Gln Pro Pro Pro Glu Thr Phe Asp Phe Lys Ile Lys Phe Ala 
545                 550                 555                 560 


Glu Thr Lys Ala His Ala Lys Ala Ile Glu Met Glu Leu Arg Gln Met 
                565                 570                 575     


Glu Val Ala Gln Ala Asn Arg His Met Ser Leu Leu Thr Ala Phe Met 
            580                 585                 590         


Pro Asp Ser Phe Leu Arg Pro Gly Gly Asp His Asp Cys Val Leu Val 
        595                 600                 605             


Leu Leu Leu Met Pro Arg Leu Ile Cys Lys Ala Glu Leu Ile Arg Lys 
    610                 615                 620                 


Gln Ala Gln Glu Lys Phe Glu Leu Ser Glu Asn Cys Ser Glu Arg Pro 
625                 630                 635                 640 


Gly Leu Arg Gly Ala Ala Gly Glu Gln Leu Ser Phe Ala Ala Gly Leu 
                645                 650                 655     


Val Tyr Ser Leu Ser Leu Leu Gln Ala Thr Leu His Arg Tyr Glu His 
            660                 665                 670         


Ala Leu Ser Gln Cys Ser Val Asp Val Tyr Lys Lys Val Gly Ser Leu 
        675                 680                 685             


Tyr Pro Glu Met Ser Ala His Glu Arg Ser Leu Asp Phe Leu Ile Glu 
    690                 695                 700                 


Leu Leu His Lys Asp Gln Leu Asp Glu Thr Val Asn Val Glu Pro Leu 
705                 710                 715                 720 


Thr Lys Ala Ile Lys Tyr Tyr Gln His Leu Tyr Ser Ile His Leu Ala 
                725                 730                 735     


Glu Gln Pro Glu Asp Cys Thr Met Gln Leu Ala Asp His Ile Lys Phe 
            740                 745                 750         


Thr Gln Ser Ala Leu Asp Cys Met Ser Val Glu Val Gly Arg Leu Arg 
        755                 760                 765             


Ala Phe Leu Gln Gly Gly Gln Glu Ala Thr Asp Ile Ala Leu Leu Leu 
    770                 775                 780                 


Arg Asp Leu Glu Thr Ser Cys Ser Asp Ile Arg Gln Phe Cys Lys Lys 
785                 790                 795                 800 


Ile Arg Arg Arg Met Pro Gly Thr Asp Ala Pro Gly Ile Pro Ala Ala 
                805                 810                 815     


Leu Ala Phe Gly Pro Gln Val Ser Asp Thr Leu Leu Asp Cys Arg Lys 
            820                 825                 830         


His Leu Thr Trp Val Val Ala Val Leu Gln Glu Val Ala Ala Ala Ala 
        835                 840                 845             


Ala Gln Leu Ile Ala Pro Leu Ala Glu Asn Glu Gly Leu Leu Val Ala 
    850                 855                 860                 


Ala Leu Glu Glu Leu Ala Phe Lys Ala Ser Glu Gln Ile Tyr Gly Thr 
865                 870                 875                 880 


Pro Ser Ser Ser Pro Tyr Glu Cys Leu Arg Gln Ser Cys Asn Ile Leu 
                885                 890                 895     


Ile Ser Thr Met Asn Lys Leu Ala Thr Ala Met Gln Glu Gly Glu Tyr 
            900                 905                 910         


Asp Ala Glu Arg Pro Pro Ser Lys Pro Pro Pro Val Glu Leu Arg Ala 
        915                 920                 925             


Ala Ala Leu Arg Ala Glu Ile Thr Asp Ala Glu Gly Leu Gly Leu Lys 
    930                 935                 940                 


Leu Glu Asp Arg Glu Thr Val Ile Lys Glu Leu Lys Lys Ser Leu Lys 
945                 950                 955                 960 


Ile Lys Gly Glu Glu Leu Ser Glu Ala Asn Val Arg Leu Ser Leu Leu 
                965                 970                 975     


Glu Lys Lys Leu Asp Ser Ala Ala Lys Asp Ala Asp Glu Arg Ile Glu 
            980                 985                 990         


Lys Val Gln Thr Arg Leu Glu Glu  Thr Gln Ala Leu Leu  Arg Lys Lys 
        995                 1000                 1005             


Glu Lys  Glu Phe Glu Glu Thr  Met Asp Ala Leu Gln  Ala Asp Ile 
    1010                 1015                 1020             


Asp Gln  Leu Glu Ala Glu Lys  Ala Glu Leu Lys Gln  Arg Leu Asn 
    1025                 1030                 1035             


Ser Gln  Ser Lys Arg Thr Ile  Glu Gly Leu Arg Gly  Pro Pro Pro 
    1040                 1045                 1050             


Ser Gly  Ile Ala Thr Leu Val  Ser Gly Ile Ala Gly  Val Tyr Arg 
    1055                 1060                 1065             


Arg Lys  His Gln Glu Leu Gln  Ala Met Gln Met Glu  Leu Gln Ser 
    1070                 1075                 1080             


Pro Glu  Tyr Lys Leu Ser Lys  Leu Arg Thr Ser Thr  Ile Met Thr 
    1085                 1090                 1095             


Asp Tyr  Asn Pro Asn Tyr Cys  Phe Ala Gly Lys Thr  Ser Ser Ile 
    1100                 1105                 1110             


Ser Asp  Leu Lys Glu Val Pro  Arg Lys Asn Ile Thr  Leu Ile Arg 
    1115                 1120                 1125             


Gly Leu  Gly His Gly Ala Phe  Gly Glu Val Tyr Glu  Gly Gln Val 
    1130                 1135                 1140             


Ser Gly  Met Pro Asn Asp Pro  Ser Pro Leu Gln Val  Ala Val Lys 
    1145                 1150                 1155             


Thr Leu  Pro Glu Val Cys Ser  Glu Gln Asp Glu Leu  Asp Phe Leu 
    1160                 1165                 1170             


Met Glu  Ala Leu Ile Ile Ser  Lys Phe Asn His Gln  Asn Ile Val 
    1175                 1180                 1185             


Arg Cys  Ile Gly Val Ser Leu  Gln Ser Leu Pro Arg  Phe Ile Leu 
    1190                 1195                 1200             


Leu Glu  Leu Met Ala Gly Gly  Asp Leu Lys Ser Phe  Leu Arg Glu 
    1205                 1210                 1215             


Thr Arg  Pro Arg Pro Ser Gln  Pro Ser Ser Leu Ala  Met Leu Asp 
    1220                 1225                 1230             


Leu Leu  His Val Ala Arg Asp  Ile Ala Cys Gly Cys  Gln Tyr Leu 
    1235                 1240                 1245             


Glu Glu  Asn His Phe Ile His  Arg Asp Ile Ala Ala  Arg Asn Cys 
    1250                 1255                 1260             


Leu Leu  Thr Cys Pro Gly Pro  Gly Arg Val Ala Lys  Ile Gly Asp 
    1265                 1270                 1275             


Phe Gly  Met Ala Arg Asp Ile  Tyr Arg Ala Ser Tyr  Tyr Arg Lys 
    1280                 1285                 1290             


Gly Gly  Cys Ala Met Leu Pro  Val Lys Trp Met Pro  Pro Glu Ala 
    1295                 1300                 1305             


Phe Met  Glu Gly Ile Phe Thr  Ser Lys Thr Asp Thr  Trp Ser Phe 
    1310                 1315                 1320             


Gly Val  Leu Leu Trp Glu Ile  Phe Ser Leu Gly Tyr  Met Pro Tyr 
    1325                 1330                 1335             


Pro Ser  Lys Ser Asn Gln Glu  Val Leu Glu Phe Val  Thr Ser Gly 
    1340                 1345                 1350             


Gly Arg  Met Asp Pro Pro Lys  Asn Cys Pro Gly Pro  Val Tyr Arg 
    1355                 1360                 1365             


Ile Met  Thr Gln Cys Trp Gln  His Gln Pro Glu Asp  Arg Pro Asn 
    1370                 1375                 1380             


Phe Ala  Ile Ile Leu Glu Arg  Ile Glu Tyr Cys Thr  Gln Asp Pro 
    1385                 1390                 1395             


Asp Val  Ile Asn Thr Ala Leu  Pro Ile Glu Tyr Gly  Pro Leu Val 
    1400                 1405                 1410             


Glu Glu  Glu Glu Lys Val Pro  Val Arg Pro Lys Asp  Pro Glu Gly 
    1415                 1420                 1425             


Val Pro  Pro Leu Leu Val Ser  Gln Gln Ala Lys Arg  Glu Glu Glu 
    1430                 1435                 1440             


Arg Ser  Pro Ala Ala Pro Pro  Pro Leu Pro Thr Thr  Ser Ser Gly 
    1445                 1450                 1455             


Lys Ala  Ala Lys Lys Pro Thr  Ala Ala Glu Ile Ser  Val Arg Val 
    1460                 1465                 1470             


Pro Arg  Gly Pro Ala Val Glu  Gly Gly His Val Asn  Met Ala Phe 
    1475                 1480                 1485             


Ser Gln  Ser Asn Pro Pro Ser  Glu Leu His Lys Val  His Gly Ser 
    1490                 1495                 1500             


Arg Asn  Lys Pro Thr Ser Leu  Trp Asn Pro Thr Tyr  Gly Ser Trp 
    1505                 1510                 1515             


Phe Thr  Glu Lys Pro Thr Lys  Lys Asn Asn Pro Ile  Ala Lys Lys 
    1520                 1525                 1530             


Glu Pro  His Asp Arg Gly Asn  Leu Gly Leu Glu Gly  Ser Cys Thr 
    1535                 1540                 1545             


Val Pro  Pro Asn Val Ala Thr  Gly Arg Leu Pro Gly  Ala Ser Leu 
    1550                 1555                 1560             


Leu Leu  Glu Pro Ser Ser Leu  Thr Ala Asn Met Lys  Glu Val Pro 
    1565                 1570                 1575             


Leu Phe  Arg Leu Arg His Phe  Pro Cys Gly Asn Val  Asn Tyr Gly 
    1580                 1585                 1590             


Tyr Gln  Gln Gln Gly Leu Pro  Leu Glu Ala Ala Thr  Ala Pro Gly 
    1595                 1600                 1605             


Ala Gly  His Tyr Glu Asp Thr  Ile Leu Lys Ser Lys  Asn Ser Met 
    1610                 1615                 1620             


Asn Gln  Pro Gly Pro 
    1625             


<210> 8
<211> 68
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 8
ataaaaattt aaagaaatta gctgggcata ggggtcccca ggggaggatg aggcaggtct       60

ggagacct                                                                68


<210> 9
<211> 1728
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(1725)

<400> 9
atg gag acc ccg tcc cag cgg cgc gcc acc cgc agc ggg gcg cag gcc         48
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala           
1               5                   10                  15                

agc tcc act ccg ctg tcg ccc acc cgc atc acc cgg ctg cag gag aag         96
Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys           
            20                  25                  30                    

gag gac ctg cag gag ctc aat gat cgc ttg gcg gtc tac atc gac cgt        144
Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg           
        35                  40                  45                        

gtg cgc tcg ctg gaa acg gag aac gca ggg ctg cgc ctt cgc atc acc        192
Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr           
    50                  55                  60                            

gag tct gaa gag gtg gtc agc cgc gag gtg tcc ggc atc aag gcc gcc        240
Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala           
65                  70                  75                  80            

tac gag gcc gag ctc ggg gat gcc cgc aag acc ctt gac tca gta gcc        288
Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala           
                85                  90                  95                

aag gag cgc gcc cgc ctg cag ctg gag ctg agc aaa gtg cgt gag gag        336
Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu           
            100                 105                 110                   

ttt aag gag ctg aaa gcg cgc aat acc aag aag gag ggt gac ctg ata        384
Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile           
        115                 120                 125                       

gct gct cag gct cgg ctg aag gac ctg gag gct ctg ctg aac tcc aag        432
Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys           
    130                 135                 140                           

gag gcc gca ctg agc act gct ctc agt gag aag cgc acg ctg gag ggc        480
Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly           
145                 150                 155                 160           

gag ctg cat gat ctg cgg ggc cag gtg gcc aag gtc tcc ttc tcg ccg        528
Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Val Ser Phe Ser Pro           
                165                 170                 175               

gtg gac act aac agc aca tct gga gac ccg gtg gag aag aag gac gaa        576
Val Asp Thr Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu           
            180                 185                 190                   

aca cct ttt ggg gtc tcg gtg gct gtg ggc ctg gcc gtc ttt gcc tgc        624
Thr Pro Phe Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys           
        195                 200                 205                       

ctc ttc ctt tct acg ctg ctc ctt gtg ctc aac aaa tgt gga cgg aga        672
Leu Phe Leu Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg           
    210                 215                 220                           

aac aag ttt ggg atc aac cgc ccg gct gtg ctg gct cca gag gat ggg        720
Asn Lys Phe Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly           
225                 230                 235                 240           

ctg gcc atg tcc ctg cat ttc atg aca ttg ggt ggc agc tcc ctg tcc        768
Leu Ala Met Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser           
                245                 250                 255               

ccc acc gag ggc aaa ggc tct ggg ctc caa ggc cac atc atc gag aac        816
Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn           
            260                 265                 270                   

cca caa tac ttc agt gat gcc tgt gtt cac cac atc aag cgc cgg gac        864
Pro Gln Tyr Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp           
        275                 280                 285                       

atc gtg ctc aag tgg gag ctg ggg gag ggc gcc ttt ggg aag gtc ttc        912
Ile Val Leu Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe           
    290                 295                 300                           

ctt gct gag tgc cac aac ctc ctg cct gag cag gac aag atg ctg gtg        960
Leu Ala Glu Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val           
305                 310                 315                 320           

gct gtc aag gca ctg aag gag gcg tcc gag agt gct cgg cag gac ttc       1008
Ala Val Lys Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe           
                325                 330                 335               

caa cgt gag gct gag ctg ctc acc atg ctg cag cac cag cac atc gtg       1056
Gln Arg Glu Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val           
            340                 345                 350                   

cgc ttc ttc ggc gtc tgc acc gag ggc cgc ccc ctg ctc atg gtc ttc       1104
Arg Phe Phe Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe           
        355                 360                 365                       

gag tat atg cgg cac ggg gac ctc aac cgc ttc ctc cga tcc cat gga       1152
Glu Tyr Met Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly           
    370                 375                 380                           

ccc gat gcc aag ctg ctg gct ggt ggg gag gat gtg gct cca ggc ccc       1200
Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro           
385                 390                 395                 400           

ctg ggt ctg ggg cag ctg ctg gcc gtg gct agc cag gtc gct gcg ggg       1248
Leu Gly Leu Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly           
                405                 410                 415               

atg gtg tac ctg gcg ggt ctg cat ttt gtg cac cgg gac ctg gcc aca       1296
Met Val Tyr Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr           
            420                 425                 430                   

cgc aac tgt cta gtg ggc cag gga ctg gtg gtc aag att ggt gat ttt       1344
Arg Asn Cys Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe           
        435                 440                 445                       

ggc atg agc agg gat atc tac agc acc gac tat tac cgt gtg gga ggc       1392
Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly           
    450                 455                 460                           

cgc acc atg ctg ccc att cgc tgg atg ccg ccc gag agc atc ctg tac       1440
Arg Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr           
465                 470                 475                 480           

cgt aag ttc acc acc gag agc gac gtg tgg agc ttc ggc gtg gtg ctc       1488
Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu           
                485                 490                 495               

tgg gag atc ttc acc tac ggc aag cag ccc tgg tac cag ctc tcc aac       1536
Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn           
            500                 505                 510                   

acg gag gca atc gac tgc atc acg cag gga cgt gag ttg gag cgg cca       1584
Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro           
        515                 520                 525                       

cgt gcc tgc cca cca gag gtc tac gcc atc atg cgg ggc tgc tgg cag       1632
Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln           
    530                 535                 540                           

cgg gag ccc cag caa cgc cac agc atc aag gat gtg cac gcc cgg ctg       1680
Arg Glu Pro Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu           
545                 550                 555                 560           

caa gcc ctg gcc cag gca cct cct gtc tac ctg gat gtc ctg ggc tag       1728
Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly               
                565                 570                 575               


<210> 10
<211> 575
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 10
Met Glu Thr Pro Ser Gln Arg Arg Ala Thr Arg Ser Gly Ala Gln Ala 
1               5                   10                  15      


Ser Ser Thr Pro Leu Ser Pro Thr Arg Ile Thr Arg Leu Gln Glu Lys 
            20                  25                  30          


Glu Asp Leu Gln Glu Leu Asn Asp Arg Leu Ala Val Tyr Ile Asp Arg 
        35                  40                  45              


Val Arg Ser Leu Glu Thr Glu Asn Ala Gly Leu Arg Leu Arg Ile Thr 
    50                  55                  60                  


Glu Ser Glu Glu Val Val Ser Arg Glu Val Ser Gly Ile Lys Ala Ala 
65                  70                  75                  80  


Tyr Glu Ala Glu Leu Gly Asp Ala Arg Lys Thr Leu Asp Ser Val Ala 
                85                  90                  95      


Lys Glu Arg Ala Arg Leu Gln Leu Glu Leu Ser Lys Val Arg Glu Glu 
            100                 105                 110         


Phe Lys Glu Leu Lys Ala Arg Asn Thr Lys Lys Glu Gly Asp Leu Ile 
        115                 120                 125             


Ala Ala Gln Ala Arg Leu Lys Asp Leu Glu Ala Leu Leu Asn Ser Lys 
    130                 135                 140                 


Glu Ala Ala Leu Ser Thr Ala Leu Ser Glu Lys Arg Thr Leu Glu Gly 
145                 150                 155                 160 


Glu Leu His Asp Leu Arg Gly Gln Val Ala Lys Val Ser Phe Ser Pro 
                165                 170                 175     


Val Asp Thr Asn Ser Thr Ser Gly Asp Pro Val Glu Lys Lys Asp Glu 
            180                 185                 190         


Thr Pro Phe Gly Val Ser Val Ala Val Gly Leu Ala Val Phe Ala Cys 
        195                 200                 205             


Leu Phe Leu Ser Thr Leu Leu Leu Val Leu Asn Lys Cys Gly Arg Arg 
    210                 215                 220                 


Asn Lys Phe Gly Ile Asn Arg Pro Ala Val Leu Ala Pro Glu Asp Gly 
225                 230                 235                 240 


Leu Ala Met Ser Leu His Phe Met Thr Leu Gly Gly Ser Ser Leu Ser 
                245                 250                 255     


Pro Thr Glu Gly Lys Gly Ser Gly Leu Gln Gly His Ile Ile Glu Asn 
            260                 265                 270         


Pro Gln Tyr Phe Ser Asp Ala Cys Val His His Ile Lys Arg Arg Asp 
        275                 280                 285             


Ile Val Leu Lys Trp Glu Leu Gly Glu Gly Ala Phe Gly Lys Val Phe 
    290                 295                 300                 


Leu Ala Glu Cys His Asn Leu Leu Pro Glu Gln Asp Lys Met Leu Val 
305                 310                 315                 320 


Ala Val Lys Ala Leu Lys Glu Ala Ser Glu Ser Ala Arg Gln Asp Phe 
                325                 330                 335     


Gln Arg Glu Ala Glu Leu Leu Thr Met Leu Gln His Gln His Ile Val 
            340                 345                 350         


Arg Phe Phe Gly Val Cys Thr Glu Gly Arg Pro Leu Leu Met Val Phe 
        355                 360                 365             


Glu Tyr Met Arg His Gly Asp Leu Asn Arg Phe Leu Arg Ser His Gly 
    370                 375                 380                 


Pro Asp Ala Lys Leu Leu Ala Gly Gly Glu Asp Val Ala Pro Gly Pro 
385                 390                 395                 400 


Leu Gly Leu Gly Gln Leu Leu Ala Val Ala Ser Gln Val Ala Ala Gly 
                405                 410                 415     


Met Val Tyr Leu Ala Gly Leu His Phe Val His Arg Asp Leu Ala Thr 
            420                 425                 430         


Arg Asn Cys Leu Val Gly Gln Gly Leu Val Val Lys Ile Gly Asp Phe 
        435                 440                 445             


Gly Met Ser Arg Asp Ile Tyr Ser Thr Asp Tyr Tyr Arg Val Gly Gly 
    450                 455                 460                 


Arg Thr Met Leu Pro Ile Arg Trp Met Pro Pro Glu Ser Ile Leu Tyr 
465                 470                 475                 480 


Arg Lys Phe Thr Thr Glu Ser Asp Val Trp Ser Phe Gly Val Val Leu 
                485                 490                 495     


Trp Glu Ile Phe Thr Tyr Gly Lys Gln Pro Trp Tyr Gln Leu Ser Asn 
            500                 505                 510         


Thr Glu Ala Ile Asp Cys Ile Thr Gln Gly Arg Glu Leu Glu Arg Pro 
        515                 520                 525             


Arg Ala Cys Pro Pro Glu Val Tyr Ala Ile Met Arg Gly Cys Trp Gln 
    530                 535                 540                 


Arg Glu Pro Gln Gln Arg His Ser Ile Lys Asp Val His Ala Arg Leu 
545                 550                 555                 560 


Gln Ala Leu Ala Gln Ala Pro Pro Val Tyr Leu Asp Val Leu Gly 
                565                 570                 575 


<210> 11
<211> 3813
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide


<220>
<221> CDS
<222> (1)..(3810)

<400> 11
atg gga gcc atc ggg ctc ctg tgg ctc ctg ccg ctg ctg ctt tcc acg         48
Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr           
1               5                   10                  15                

gca gct gtg ggc tcc ggg atg ggg acc ggc cag cgc gcg ggc tcc cca         96
Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro           
            20                  25                  30                    

gct gcg ggg ccg ccg ctg cag ccc cgg gag cca ctc agc tac tcg cgc        144
Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg           
        35                  40                  45                        

ctg cag agg aag agt ctg gca gtt gac ttc gtg gtg ccc tcg ctc ttc        192
Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe           
    50                  55                  60                            

cgt gtc tac gcc cgg gac cta ctg ctg cca cca tcc tcc tcg gag ctg        240
Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu           
65                  70                  75                  80            

aag gct ggc agg ccc gag gcc cgc ggc tcg cta gct ctg gac tgc gcc        288
Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala           
                85                  90                  95                

ccg ctg ctc agg ttg ctg ggg ccg gcg ccg ggg gtc tcc tgg acc gcc        336
Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala           
            100                 105                 110                   

ggt tca cca gcc ccg gca gag gcc cgg acg ctg tcc agg gtg ctg aag        384
Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys           
        115                 120                 125                       

ggc ggc tcc gtg cgc aag ctc cgg cgt gcc aag cag ttg gtg ctg gag        432
Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu           
    130                 135                 140                           

ctg ggc gag gag gcg atc ttg gag ggt tgc gtc ggg ccc ccc ggg gag        480
Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu           
145                 150                 155                 160           

gcg gct gtg ggg ctg ctc cag ttc aat ctc agc gag ctg ttc agt tgg        528
Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp           
                165                 170                 175               

tgg att cgc caa ggc gaa ggg cga ctg agg atc cgc ctg atg ccc gag        576
Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu           
            180                 185                 190                   

aag aag gcg tcg gaa gtg ggc aga gag gga agg ctg tcc gcg gca att        624
Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile           
        195                 200                 205                       

cgc gcc tcc cag ccc cgc ctt ctc ttc cag atc ttc ggg act ggt cat        672
Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His           
    210                 215                 220                           

agc tcc ttg gaa tca cca aca aac atg cct tct cct tct cct gat tat        720
Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr           
225                 230                 235                 240           

ttt aca tgg aat ctc acc tgg ata atg aaa gac tcc ttc cct ttc ctg        768
Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu           
                245                 250                 255               

tct cat cgc agc cga tat ggt ctg gag tgc agc ttt gac ttc ccc tgt        816
Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys           
            260                 265                 270                   

gag ctg gag tat tcc cct cca ctg cat gac ctc agg aac cag agc tgg        864
Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp           
        275                 280                 285                       

tcc tgg cgc cgc atc ccc tcc gag gag gcc tcc cag atg gac ttg ctg        912
Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu           
    290                 295                 300                           

gat ggg cct ggg gca gag cgt tct aag gag atg ccc aga ggc tcc ttt        960
Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe           
305                 310                 315                 320           

ctc ctt ctc aac acc tca gct gac tcc aag cac acc atc ctg agt ccg       1008
Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro           
                325                 330                 335               

tgg atg agg agc agc agt gag cac tgc aca ctg gcc gtc tcg gtg cac       1056
Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His           
            340                 345                 350                   

agg cac ctg cag ccc tct gga agg tac att gcc cag ctg ctg ccc cac       1104
Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His           
        355                 360                 365                       

aac gag gct gca aga gag atc ctc ctg atg ccc act cca ggg aag cat       1152
Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His           
    370                 375                 380                           

ggt tgg aca gtg ctc cag gga aga atc ggg cgt cca gac aac cca ttt       1200
Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe           
385                 390                 395                 400           

cga gtg gcc ctg gaa tac atc tcc agt gga aac cgc agc ttg tct gca       1248
Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala           
                405                 410                 415               

gtg gac ttc ttt gcc ctg aag aac tgc agt gaa gga aca tcc cca ggc       1296
Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly           
            420                 425                 430                   

tcc aag atg gcc ctg cag agc tcc ttc act tgt tgg aat ggg aca gtc       1344
Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val           
        435                 440                 445                       

ctc cag ctt ggg cag gcc tgt gac ttc cac cag gac tgt gcc cag gga       1392
Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly           
    450                 455                 460                           

gaa gat gag agc cag atg tgc cgg aaa ctg cct gtg ggt ttt tac tgc       1440
Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys           
465                 470                 475                 480           

aac ttt gaa gat ggc ttc tgt ggc tgg acc caa ggc aca ctg tca ccc       1488
Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro           
                485                 490                 495               

cac act cct caa tgg cag gtc agg acc cta aag gat gcc cgg ttc cag       1536
His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln           
            500                 505                 510                   

gac cac caa gac cat gct cta ttg ctc agt acc act gat gtc ccc gct       1584
Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala           
        515                 520                 525                       

tct gaa agt gct aca gtg acc agt gct acg ttt cct gca ccg atc aag       1632
Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys           
    530                 535                 540                           

agc tct cca tgt gag ctc cga atg tcc tgg ctc att cgt gga gtc ttg       1680
Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu           
545                 550                 555                 560           

agg gga aac gtg tcc ttg gtg cta gtg gag aac aaa acc ggg aag gag       1728
Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu           
                565                 570                 575               

caa ggc agg atg gtc tgg cat gtc gcc gcc tat gaa ggc ttg agc ctg       1776
Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu           
            580                 585                 590                   

tgg cag tgg atg gtg ttg cct ctc ctc gat gtg tct gac agg ttc tgg       1824
Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp           
        595                 600                 605                       

ctg cag atg gtc gca tgg tgg gga caa gga tcc aga gcc atc gtg gct       1872
Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala           
    610                 615                 620                           

ttt gac aat atc tcc atc agc ctg gac tgc tac ctc acc att agc gga       1920
Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly           
625                 630                 635                 640           

gag gac aag atc ctg cag aat aca gca ccc aaa tca aga aac ctg ttt       1968
Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe           
                645                 650                 655               

gag aga aac cca aac aag gag ctg aaa ccc ggg gaa aat tca cca aga       2016
Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg           
            660                 665                 670                   

cag acc ccc atc ttt gac cct aca gtt cat tgg ctg ttc acc aca tgt       2064
Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys           
        675                 680                 685                       

ggg gcc agc ggg ccc cat ggc ccc acc cag gca cag tgc aac aac gcc       2112
Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala           
    690                 695                 700                           

tac cag aac tcc aac ctg agc gtg gag gtg ggg agc gag ggc ccc ctg       2160
Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu           
705                 710                 715                 720           

aaa ggc atc cag atc tgg aag gtg cca gcc acc gac acc tac agc atc       2208
Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile           
                725                 730                 735               

tcg ggc tac gga gct gct ggc ggg aaa ggc ggg aag aac acc atg atg       2256
Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met           
            740                 745                 750                   

cgg tcc cac ggc gtg tct gtg ctg ggc atc ttc aac ctg gag aag gat       2304
Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp           
        755                 760                 765                       

gac atg ctg tac atc ctg gtt ggg cag cag gga gag gac gcc tgc ccc       2352
Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro           
    770                 775                 780                           

agt aca aac cag tta atc cag aaa gtc tgc att gga gag aac aat gtg       2400
Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val           
785                 790                 795                 800           

ata gaa gaa gaa atc cgt gtg aac aga agc gtg cat gag tgg gca gga       2448
Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly           
                805                 810                 815               

ggc gga gga gga ggg ggt gga gcc acc tac gta ttt aag atg aag gat       2496
Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp           
            820                 825                 830                   

gga gtg ccg gtg ccc ctg atc att gca gcc gga ggt ggt ggc agg gcc       2544
Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala           
        835                 840                 845                       

tac ggg gcc aag aca gac acg ttc cac cca gag aga ctg gag aat aac       2592
Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn           
    850                 855                 860                           

tcc tcg gtt cta ggg cta aac ggc aat tcc gga gcc gca ggt ggt gga       2640
Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly           
865                 870                 875                 880           

ggt ggc tgg aat gat aac act tcc ttg ctc tgg gcc gga aaa tct ttg       2688
Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu           
                885                 890                 895               

cag gag ggt gcc acc gga gga cat tcc tgc ccc cag gcc atg aag aag       2736
Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys           
            900                 905                 910                   

tgg ggg tgg gag aca aga ggg ggt ttc gga ggg ggt gga ggg ggg tgc       2784
Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys           
        915                 920                 925                       

tcc tca ggt gga gga ggc gga gga tat ata ggc ggc aat gca gcc tca       2832
Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser           
    930                 935                 940                           

aac aat gac ccc gaa atg gat ggg gaa gat ggg gtt tcc ttc atc agt       2880
Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser           
945                 950                 955                 960           

cca ctg ggc atc ctg tac acc cca gct tta aaa gtg atg gaa ggc cac       2928
Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His           
                965                 970                 975               

ggg gaa gtg aat att aag cat tat cta aac tgc agt cac tgt gag gta       2976
Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val           
            980                 985                 990                   

gac gaa tgt cac atg gac cct gaa  agc cac aag gtc atc  tgc ttc tgt     3024
Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys         
        995                 1000                 1005                     

gac cac  ggg acg gtg ctg gct  gag gat ggc gtc tcc  tgc att gtg        3069
Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val            
    1010                 1015                 1020                        

tca ccc  acc ccg gag cca cac  ctg cca ctc tcg ctg  atc ctc tct        3114
Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser            
    1025                 1030                 1035                        

gtg gtg  acc tct gcc ctc gtg  gcc gcc ctg gtc ctg  gct ttc tcc        3159
Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser            
    1040                 1045                 1050                        

ggc atc  atg att gaa gaa cag  cag cga gga gcc atc  cct ggg cag        3204
Gly Ile  Met Ile Glu Glu Gln  Gln Arg Gly Ala Ile  Pro Gly Gln            
    1055                 1060                 1065                        

gct cca  ggg tct gtg cca ggc  cca ggg ctg gtg aag  gac tca cca        3249
Ala Pro  Gly Ser Val Pro Gly  Pro Gly Leu Val Lys  Asp Ser Pro            
    1070                 1075                 1080                        

ctg ctg  ctt cag cag atc tct  gcc atg agg ctg cac  atc tcc cag        3294
Leu Leu  Leu Gln Gln Ile Ser  Ala Met Arg Leu His  Ile Ser Gln            
    1085                 1090                 1095                        

ctc cag  cat gag aac agc atc  ctc aag gga gcc cag  atg aag gca        3339
Leu Gln  His Glu Asn Ser Ile  Leu Lys Gly Ala Gln  Met Lys Ala            
    1100                 1105                 1110                        

tcc ttg  gca tcc ctg ccc cct  ctg cat gtt gca aag  cta tcc cat        3384
Ser Leu  Ala Ser Leu Pro Pro  Leu His Val Ala Lys  Leu Ser His            
    1115                 1120                 1125                        

gag ggc  cct ggc agt gag tta  cca gct gga gcg ctg  tat cgt aag        3429
Glu Gly  Pro Gly Ser Glu Leu  Pro Ala Gly Ala Leu  Tyr Arg Lys            
    1130                 1135                 1140                        

acc agc  cag ctg ctg gag aca  ttg aat caa ttg agc  aca cac acg        3474
Thr Ser  Gln Leu Leu Glu Thr  Leu Asn Gln Leu Ser  Thr His Thr            
    1145                 1150                 1155                        

cac gta  gta gac atc act cgc  acc agc cct gct gcc  aag agc ccg        3519
His Val  Val Asp Ile Thr Arg  Thr Ser Pro Ala Ala  Lys Ser Pro            
    1160                 1165                 1170                        

tcg gcc  caa ctt atg gag caa  gtg gct cag ctt aag  tcc ctg agt        3564
Ser Ala  Gln Leu Met Glu Gln  Val Ala Gln Leu Lys  Ser Leu Ser            
    1175                 1180                 1185                        

gac acc  gtc gag aag ctc aag  gat gag gtc ctc aag  gag aca gta        3609
Asp Thr  Val Glu Lys Leu Lys  Asp Glu Val Leu Lys  Glu Thr Val            
    1190                 1195                 1200                        

tct cag  cgc cct gga gcc aca  gta ccc act gac ttt  gcc acc ttc        3654
Ser Gln  Arg Pro Gly Ala Thr  Val Pro Thr Asp Phe  Ala Thr Phe            
    1205                 1210                 1215                        

cct tca  tca gcc ttc ctc agg  gcc aag gag gag cag  cag gat gac        3699
Pro Ser  Ser Ala Phe Leu Arg  Ala Lys Glu Glu Gln  Gln Asp Asp            
    1220                 1225                 1230                        

aca gtc  tac atg ggc aaa gtg  acc ttc tca tgt gcg  gct ggt ttt        3744
Thr Val  Tyr Met Gly Lys Val  Thr Phe Ser Cys Ala  Ala Gly Phe            
    1235                 1240                 1245                        

gga cag  cga cac cgg ctg gtg  ctg acc cag gag cag  ctg cac cag        3789
Gly Gln  Arg His Arg Leu Val  Leu Thr Gln Glu Gln  Leu His Gln            
    1250                 1255                 1260                        

ctt cac  agt cgc ctc atc tcc  taa                                     3813
Leu His  Ser Arg Leu Ile Ser                                              
    1265                 1270                                             


<210> 12
<211> 1270
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 12
Met Gly Ala Ile Gly Leu Leu Trp Leu Leu Pro Leu Leu Leu Ser Thr 
1               5                   10                  15      


Ala Ala Val Gly Ser Gly Met Gly Thr Gly Gln Arg Ala Gly Ser Pro 
            20                  25                  30          


Ala Ala Gly Pro Pro Leu Gln Pro Arg Glu Pro Leu Ser Tyr Ser Arg 
        35                  40                  45              


Leu Gln Arg Lys Ser Leu Ala Val Asp Phe Val Val Pro Ser Leu Phe 
    50                  55                  60                  


Arg Val Tyr Ala Arg Asp Leu Leu Leu Pro Pro Ser Ser Ser Glu Leu 
65                  70                  75                  80  


Lys Ala Gly Arg Pro Glu Ala Arg Gly Ser Leu Ala Leu Asp Cys Ala 
                85                  90                  95      


Pro Leu Leu Arg Leu Leu Gly Pro Ala Pro Gly Val Ser Trp Thr Ala 
            100                 105                 110         


Gly Ser Pro Ala Pro Ala Glu Ala Arg Thr Leu Ser Arg Val Leu Lys 
        115                 120                 125             


Gly Gly Ser Val Arg Lys Leu Arg Arg Ala Lys Gln Leu Val Leu Glu 
    130                 135                 140                 


Leu Gly Glu Glu Ala Ile Leu Glu Gly Cys Val Gly Pro Pro Gly Glu 
145                 150                 155                 160 


Ala Ala Val Gly Leu Leu Gln Phe Asn Leu Ser Glu Leu Phe Ser Trp 
                165                 170                 175     


Trp Ile Arg Gln Gly Glu Gly Arg Leu Arg Ile Arg Leu Met Pro Glu 
            180                 185                 190         


Lys Lys Ala Ser Glu Val Gly Arg Glu Gly Arg Leu Ser Ala Ala Ile 
        195                 200                 205             


Arg Ala Ser Gln Pro Arg Leu Leu Phe Gln Ile Phe Gly Thr Gly His 
    210                 215                 220                 


Ser Ser Leu Glu Ser Pro Thr Asn Met Pro Ser Pro Ser Pro Asp Tyr 
225                 230                 235                 240 


Phe Thr Trp Asn Leu Thr Trp Ile Met Lys Asp Ser Phe Pro Phe Leu 
                245                 250                 255     


Ser His Arg Ser Arg Tyr Gly Leu Glu Cys Ser Phe Asp Phe Pro Cys 
            260                 265                 270         


Glu Leu Glu Tyr Ser Pro Pro Leu His Asp Leu Arg Asn Gln Ser Trp 
        275                 280                 285             


Ser Trp Arg Arg Ile Pro Ser Glu Glu Ala Ser Gln Met Asp Leu Leu 
    290                 295                 300                 


Asp Gly Pro Gly Ala Glu Arg Ser Lys Glu Met Pro Arg Gly Ser Phe 
305                 310                 315                 320 


Leu Leu Leu Asn Thr Ser Ala Asp Ser Lys His Thr Ile Leu Ser Pro 
                325                 330                 335     


Trp Met Arg Ser Ser Ser Glu His Cys Thr Leu Ala Val Ser Val His 
            340                 345                 350         


Arg His Leu Gln Pro Ser Gly Arg Tyr Ile Ala Gln Leu Leu Pro His 
        355                 360                 365             


Asn Glu Ala Ala Arg Glu Ile Leu Leu Met Pro Thr Pro Gly Lys His 
    370                 375                 380                 


Gly Trp Thr Val Leu Gln Gly Arg Ile Gly Arg Pro Asp Asn Pro Phe 
385                 390                 395                 400 


Arg Val Ala Leu Glu Tyr Ile Ser Ser Gly Asn Arg Ser Leu Ser Ala 
                405                 410                 415     


Val Asp Phe Phe Ala Leu Lys Asn Cys Ser Glu Gly Thr Ser Pro Gly 
            420                 425                 430         


Ser Lys Met Ala Leu Gln Ser Ser Phe Thr Cys Trp Asn Gly Thr Val 
        435                 440                 445             


Leu Gln Leu Gly Gln Ala Cys Asp Phe His Gln Asp Cys Ala Gln Gly 
    450                 455                 460                 


Glu Asp Glu Ser Gln Met Cys Arg Lys Leu Pro Val Gly Phe Tyr Cys 
465                 470                 475                 480 


Asn Phe Glu Asp Gly Phe Cys Gly Trp Thr Gln Gly Thr Leu Ser Pro 
                485                 490                 495     


His Thr Pro Gln Trp Gln Val Arg Thr Leu Lys Asp Ala Arg Phe Gln 
            500                 505                 510         


Asp His Gln Asp His Ala Leu Leu Leu Ser Thr Thr Asp Val Pro Ala 
        515                 520                 525             


Ser Glu Ser Ala Thr Val Thr Ser Ala Thr Phe Pro Ala Pro Ile Lys 
    530                 535                 540                 


Ser Ser Pro Cys Glu Leu Arg Met Ser Trp Leu Ile Arg Gly Val Leu 
545                 550                 555                 560 


Arg Gly Asn Val Ser Leu Val Leu Val Glu Asn Lys Thr Gly Lys Glu 
                565                 570                 575     


Gln Gly Arg Met Val Trp His Val Ala Ala Tyr Glu Gly Leu Ser Leu 
            580                 585                 590         


Trp Gln Trp Met Val Leu Pro Leu Leu Asp Val Ser Asp Arg Phe Trp 
        595                 600                 605             


Leu Gln Met Val Ala Trp Trp Gly Gln Gly Ser Arg Ala Ile Val Ala 
    610                 615                 620                 


Phe Asp Asn Ile Ser Ile Ser Leu Asp Cys Tyr Leu Thr Ile Ser Gly 
625                 630                 635                 640 


Glu Asp Lys Ile Leu Gln Asn Thr Ala Pro Lys Ser Arg Asn Leu Phe 
                645                 650                 655     


Glu Arg Asn Pro Asn Lys Glu Leu Lys Pro Gly Glu Asn Ser Pro Arg 
            660                 665                 670         


Gln Thr Pro Ile Phe Asp Pro Thr Val His Trp Leu Phe Thr Thr Cys 
        675                 680                 685             


Gly Ala Ser Gly Pro His Gly Pro Thr Gln Ala Gln Cys Asn Asn Ala 
    690                 695                 700                 


Tyr Gln Asn Ser Asn Leu Ser Val Glu Val Gly Ser Glu Gly Pro Leu 
705                 710                 715                 720 


Lys Gly Ile Gln Ile Trp Lys Val Pro Ala Thr Asp Thr Tyr Ser Ile 
                725                 730                 735     


Ser Gly Tyr Gly Ala Ala Gly Gly Lys Gly Gly Lys Asn Thr Met Met 
            740                 745                 750         


Arg Ser His Gly Val Ser Val Leu Gly Ile Phe Asn Leu Glu Lys Asp 
        755                 760                 765             


Asp Met Leu Tyr Ile Leu Val Gly Gln Gln Gly Glu Asp Ala Cys Pro 
    770                 775                 780                 


Ser Thr Asn Gln Leu Ile Gln Lys Val Cys Ile Gly Glu Asn Asn Val 
785                 790                 795                 800 


Ile Glu Glu Glu Ile Arg Val Asn Arg Ser Val His Glu Trp Ala Gly 
                805                 810                 815     


Gly Gly Gly Gly Gly Gly Gly Ala Thr Tyr Val Phe Lys Met Lys Asp 
            820                 825                 830         


Gly Val Pro Val Pro Leu Ile Ile Ala Ala Gly Gly Gly Gly Arg Ala 
        835                 840                 845             


Tyr Gly Ala Lys Thr Asp Thr Phe His Pro Glu Arg Leu Glu Asn Asn 
    850                 855                 860                 


Ser Ser Val Leu Gly Leu Asn Gly Asn Ser Gly Ala Ala Gly Gly Gly 
865                 870                 875                 880 


Gly Gly Trp Asn Asp Asn Thr Ser Leu Leu Trp Ala Gly Lys Ser Leu 
                885                 890                 895     


Gln Glu Gly Ala Thr Gly Gly His Ser Cys Pro Gln Ala Met Lys Lys 
            900                 905                 910         


Trp Gly Trp Glu Thr Arg Gly Gly Phe Gly Gly Gly Gly Gly Gly Cys 
        915                 920                 925             


Ser Ser Gly Gly Gly Gly Gly Gly Tyr Ile Gly Gly Asn Ala Ala Ser 
    930                 935                 940                 


Asn Asn Asp Pro Glu Met Asp Gly Glu Asp Gly Val Ser Phe Ile Ser 
945                 950                 955                 960 


Pro Leu Gly Ile Leu Tyr Thr Pro Ala Leu Lys Val Met Glu Gly His 
                965                 970                 975     


Gly Glu Val Asn Ile Lys His Tyr Leu Asn Cys Ser His Cys Glu Val 
            980                 985                 990         


Asp Glu Cys His Met Asp Pro Glu  Ser His Lys Val Ile  Cys Phe Cys 
        995                 1000                 1005             


Asp His  Gly Thr Val Leu Ala  Glu Asp Gly Val Ser  Cys Ile Val 
    1010                 1015                 1020             


Ser Pro  Thr Pro Glu Pro His  Leu Pro Leu Ser Leu  Ile Leu Ser 
    1025                 1030                 1035             


Val Val  Thr Ser Ala Leu Val  Ala Ala Leu Val Leu  Ala Phe Ser 
    1040                 1045                 1050             


Gly Ile  Met Ile Glu Glu Gln  Gln Arg Gly Ala Ile  Pro Gly Gln 
    1055                 1060                 1065             


Ala Pro  Gly Ser Val Pro Gly  Pro Gly Leu Val Lys  Asp Ser Pro 
    1070                 1075                 1080             


Leu Leu  Leu Gln Gln Ile Ser  Ala Met Arg Leu His  Ile Ser Gln 
    1085                 1090                 1095             


Leu Gln  His Glu Asn Ser Ile  Leu Lys Gly Ala Gln  Met Lys Ala 
    1100                 1105                 1110             


Ser Leu  Ala Ser Leu Pro Pro  Leu His Val Ala Lys  Leu Ser His 
    1115                 1120                 1125             


Glu Gly  Pro Gly Ser Glu Leu  Pro Ala Gly Ala Leu  Tyr Arg Lys 
    1130                 1135                 1140             


Thr Ser  Gln Leu Leu Glu Thr  Leu Asn Gln Leu Ser  Thr His Thr 
    1145                 1150                 1155             


His Val  Val Asp Ile Thr Arg  Thr Ser Pro Ala Ala  Lys Ser Pro 
    1160                 1165                 1170             


Ser Ala  Gln Leu Met Glu Gln  Val Ala Gln Leu Lys  Ser Leu Ser 
    1175                 1180                 1185             


Asp Thr  Val Glu Lys Leu Lys  Asp Glu Val Leu Lys  Glu Thr Val 
    1190                 1195                 1200             


Ser Gln  Arg Pro Gly Ala Thr  Val Pro Thr Asp Phe  Ala Thr Phe 
    1205                 1210                 1215             


Pro Ser  Ser Ala Phe Leu Arg  Ala Lys Glu Glu Gln  Gln Asp Asp 
    1220                 1225                 1230             


Thr Val  Tyr Met Gly Lys Val  Thr Phe Ser Cys Ala  Ala Gly Phe 
    1235                 1240                 1245             


Gly Gln  Arg His Arg Leu Val  Leu Thr Gln Glu Gln  Leu His Gln 
    1250                 1255                 1260             


Leu His  Ser Arg Leu Ile Ser  
    1265                 1270 


<210> 13
<211> 76
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 13
tgaagccaca tgaactcagt gagaaaacag gcacctgtgg cacagcctga gacactattc       60

agtcctgcct tcctgc                                                       76


