                         SEQUENCE LISTING

<110>  ENOBIA CANADA LIMITED PARTNERSHIP
       VANDERBILT UNIVERSITY
       Crine, Philippe
       Elefteriou, Florent
 
<120>  COMPOSITIONS COMPRISING ALKALINE PHOSPHATASE AND/OR NATRIURETIC 
       PEPTIDE AND METHODS OF USE THEREOF

<130>  50694-039WO4

<150>  61/549,047
<151>  2011-10-19

<150>  61/649,717
<151>  2012-05-21

<160>  1221  

<170>  PatentIn version 3.5

<210>  1
<211>  28
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  2
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Ala Pro Arg Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Met 
1               5                   10                  15      


Asp Arg Ile Gly Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25                  30          


<210>  3
<211>  32
<212>  PRT
<213>  Homo sapiens

<400>  3

Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Arg Lys Met Asp 
1               5                   10                  15      


Arg Ile Ser Ser Ser Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210>  4
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  4

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  5
<211>  38
<212>  PRT
<213>  Dendroaspis angusticeps

<400>  5

Glu Val Lys Tyr Asp Pro Cys Phe Gly His Lys Ile Asp Arg Ile Asn 
1               5                   10                  15      


His Val Ser Asn Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn 
            20                  25                  30          


Ala Pro Ser Thr Ser Ala 
        35              


<210>  6
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSENSUS SEQUENCE


<220>
<221>  MISC_FEATURE
<222>  (4)..(6)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 1-5

<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 1-5

<220>
<221>  MISC_FEATURE
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 1-5

<400>  6

Cys Phe Gly Xaa Xaa Xaa Asp Arg Ile Xaa Xaa Xaa Ser Xaa Leu Gly 
1               5                   10                  15      


Cys 
    


<210>  7

<400>  7
000

<210>  8

<400>  8
000

<210>  9

<400>  9
000

<210>  10

<400>  10
000

<210>  11
<211>  53
<212>  PRT
<213>  Homo sapiens

<400>  11

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  12
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  12

Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
1               5                   10                  15      


Cys 
    


<210>  13
<211>  22
<212>  PRT
<213>  Bos taurus

<400>  13

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  14
<211>  22
<212>  PRT
<213>  Ovis aries

<400>  14

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  15
<211>  22
<212>  PRT
<213>  Mus musculus

<400>  15

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  16
<211>  22
<212>  PRT
<213>  Sus scrofa

<400>  16

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  17
<211>  27
<212>  PRT
<213>  Micrurus fulvius fulvius

<400>  17

Gly Leu Ala Lys Glu Ala Leu Gly Asp Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Thr Ser Ser Gly Leu Gly Cys 
            20                  25          


<210>  18
<211>  18
<212>  PRT
<213>  Taeniopygia guttata

<400>  18

Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Thr Phe Ser Gly Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  19
<211>  22
<212>  PRT
<213>  Gallus gallus

<400>  19

Gly Leu Ser Arg Ser Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  20
<211>  20
<212>  PRT
<213>  Rana catesbeiana

<400>  20

Ser Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Phe Ser 
1               5                   10                  15      


Gly Leu Gly Cys 
            20  


<210>  21
<211>  22
<212>  PRT
<213>  Anguilla japonica

<400>  21

Gly Trp Asn Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Leu Ser Gly Leu Gly Cys 
            20          


<210>  22
<211>  22
<212>  PRT
<213>  Oncorhynchus mykiss

<400>  22

Gly Trp Asn Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  23
<211>  22
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  23

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Thr Ser Gly Leu Gly Cys 
            20          


<210>  24
<211>  19
<212>  PRT
<213>  Trimeresurus flavoviridis

<400>  24

Lys Gly Cys Phe Gly His Lys Leu Asp Arg Ile Gly Ser Thr Ser Gly 
1               5                   10                  15      


Leu Gly Cys 
            


<210>  25
<211>  20
<212>  PRT
<213>  Polypterus endlicheri

<400>  25

Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Ile Ser 
1               5                   10                  15      


Gly Leu Gly Cys 
            20  


<210>  26
<211>  21
<212>  PRT
<213>  Xenopus laevis

<400>  26

Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Val Val 
1               5                   10                  15      


Ser Gly Leu Gly Cys 
            20      


<210>  27
<211>  18
<212>  PRT
<213>  Oryzias latipes

<400>  27

Gly Cys Phe Gly Met Lys Met Asp Arg Ile Gly Ser Ile Ser Gly Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  28
<211>  18
<212>  PRT
<213>  Tetraodon nigroviridis

<400>  28

Gly Cys Phe Gly Met Lys Ile Asp Arg Ile Gly Ser Ile Ser Gly Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  29
<211>  23
<212>  PRT
<213>  Pseudechis australis

<400>  29

Ser Lys Ile Gly Asp Gly Cys Phe Gly Leu Pro Leu Asp His Ile Gly 
1               5                   10                  15      


Ser Val Ser Gly Leu Gly Cys 
            20              


<210>  30
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSENSUS SEQUENCE


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 4 and 13-29

<220>
<221>  MISC_FEATURE
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 4 and 13-29

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 4 and 13-29

<220>
<221>  MISC_FEATURE
<222>  (21)..(22)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 4 and 13-29

<400>  30

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Cys Phe Gly Xaa Xaa Xaa 
1               5                   10                  15      


Asp Xaa Ile Gly Xaa Xaa Ser Gly Leu Gly Cys 
            20                  25          


<210>  31
<211>  126
<212>  PRT
<213>  Oryzias latipes

<400>  31

Met Ala Val Cys Ser Ser Ser Ser Leu Ile Leu Leu Thr Val Phe Leu 
1               5                   10                  15      


Ser Val Ala Val Glu Thr Arg Pro Ser Ser Asp Arg Asp Glu Glu Gln 
            20                  25                  30          


Val Leu Lys Ser Leu Phe Gly Pro His Leu Thr Ser Leu Ile Leu Ala 
        35                  40                  45              


Pro Pro Thr Ser Asn Asp Ser Thr Glu Gly Ser Ser Gly Ser Pro Glu 
    50                  55                  60                  


Pro Pro Thr Pro Ser Glu Ala Pro Val Leu Ile His Gly Asp Arg Gly 
65                  70                  75                  80  


Thr Ala Ser Gln Ile Leu Arg Ser Phe Leu Arg Gln Arg Glu Lys Thr 
                85                  90                  95      


Arg Arg Trp Gly Arg Lys Pro Met Val Ala Gly Gly Gly Cys Phe Gly 
            100                 105                 110         


Met Lys Met Asp Arg Ile Gly Ser Ile Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  32
<211>  130
<212>  PRT
<213>  Takifugu rubripes

<400>  32

Met Ala Ala Ser Ser Ser Ser Phe Val Pro Leu Val Leu Leu Phe Leu 
1               5                   10                  15      


Ala Ile Pro Val Glu Pro Arg Pro Ser Met Thr Arg Asp Glu Ala Gln 
            20                  25                  30          


Val Leu Arg Ala Leu Phe Gly Ala Arg Leu Ser Ser Ile Ile Ser Thr 
        35                  40                  45              


Pro Val Asn Thr Asp Asp Ile Ala Glu Leu Leu Pro Arg Arg Pro Gly 
    50                  55                  60                  


Pro Pro Arg Ser Phe Gly Ala Ser Pro Gly Ala Leu Arg Gly Leu Thr 
65                  70                  75                  80  


Arg Gly Ser Glu Gly Gly Ser Arg Phe Leu Leu Asp Phe Leu Gln Gln 
                85                  90                  95      


Gln Ser Lys Thr Thr Arg Arg Gly Arg Ser Ser Met Val Gly Gly Arg 
            100                 105                 110         


Gly Cys Phe Gly Met Lys Ile Asp Arg Ile Gly Ser Ile Ser Gly Leu 
        115                 120                 125             


Gly Cys 
    130 


<210>  33
<211>  150
<212>  PRT
<213>  Acipenser transmontanus

<400>  33

Met Ser Ile Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Cys 
1               5                   10                  15      


Leu Leu Leu Ile Ser Leu Met Leu Leu Ala Ala Ser Cys Gln Gly Arg 
            20                  25                  30          


Pro Asp Leu Gln His Arg Asn His Lys Ser Gln Leu Ala Gly Leu Phe 
        35                  40                  45              


Gly Ala Glu Val Ala Ala Leu Leu Glu Asp Ala Gly Ala Ala Asp Gly 
    50                  55                  60                  


Ser Ser Gly Glu Glu Ala Ala Leu Ser Gln Arg Ala Pro Pro Ser Ile 
65                  70                  75                  80  


Arg Ala Leu His Pro Arg Ser Gly Arg Leu Gly Leu Arg Asp Asp Leu 
                85                  90                  95      


Glu Ala Glu Pro Pro Ala Glu Asn Lys Pro Arg Arg Arg Leu Leu Lys 
            100                 105                 110         


Asp Phe Met Ser Ser Arg Lys Met Phe Arg Gly Arg Thr Lys Lys Met 
        115                 120                 125             


Gln Gln Gly Arg Gly Cys Phe Gly Met Lys Leu Asp Arg Ile Gly Ser 
    130                 135                 140                 


Met Ser Gly Leu Gly Cys 
145                 150 


<210>  34
<211>  126
<212>  PRT
<213>  Mus musculus

<400>  34

Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Leu Ala Asp Ser Gln Ala Ala Gly Gly 
        35                  40                  45              


Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Ser Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  35
<211>  126
<212>  PRT
<213>  Mus musculus

<400>  35

Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Leu Ala Asp Ser Gln Ala Ala Gly Gly 
        35                  40                  45              


Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Ser Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  36
<211>  147
<212>  PRT
<213>  Notomys alexis

<400>  36

Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Leu Ala Asp Ser Gln Ala Ala Gly Gly 
        35                  40                  45              


Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Lys Gly Asp Lys Thr Pro Gly Gly 
65                  70                  75                  80  


Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu 
                85                  90                  95      


Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu 
            100                 105                 110         


His Pro Asn Ala Arg Lys Asn Lys Gly Gly Asn Lys Lys Gly Leu Ser 
        115                 120                 125             


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
    130                 135                 140                 


Leu Gly Cys 
145         


<210>  37
<211>  126
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  38
<211>  126
<212>  PRT
<213>  Bos taurus

<400>  38

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Ala Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Ser Gly Glu Glu Val Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Asp Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Thr Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  39
<211>  126
<212>  PRT
<213>  Ovis aries

<400>  39

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Ser Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Val Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Asp Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Thr Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  40
<211>  126
<212>  PRT
<213>  Sus scrofa

<400>  40

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Gly Glu Glu Val Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  41
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  41

Met His Leu Ser Gln Leu Leu Ala Cys Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Ala Pro Pro Lys Val Pro 
            20                  25                  30          


Arg Thr Pro Pro Ala Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly 
        35                  40                  45              


Gly Gln Lys Lys Gly Asp Lys Ala Pro Gly Gly Gly Gly Ala Asn Leu 
    50                  55                  60                  


Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys 
65                  70                  75                  80  


Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
                85                  90                  95      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  42
<211>  121
<212>  PRT
<213>  Ornithorhynchus anatinus

<400>  42

Met His Leu Ser His Leu Leu Ala Trp Ala Leu Leu Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Ala Glu Ala Lys Pro Pro Ser Pro Gln Pro Gln Val Pro 
            20                  25                  30          


Arg Ser Pro Gly Asp Glu Ala Ser Glu Ala Val Ala Ala Asn Gly Gly 
        35                  40                  45              


Gly Lys Lys Gly Asp Lys Glu Pro Lys Gly Asp Arg Pro Arg Leu Leu 
    50                  55                  60                  


Arg Glu Leu Arg Leu Asp Thr Arg Ser Arg Gly Ser Arg Gly Val Trp 
65                  70                  75                  80  


Thr Arg Leu Leu His Asp His Pro Asn Pro Arg Lys Tyr Lys Pro Ala 
                85                  90                  95      


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
            100                 105                 110         


Ile Gly Ser Thr Ser Gly Leu Gly Cys 
        115                 120     


<210>  43
<211>  33
<212>  PRT
<213>  Cavia porcellus

<400>  43

Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly 
1               5                   10                  15      


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
            20                  25                  30          


Cys 
    


<210>  44
<211>  121
<212>  PRT
<213>  Oryzias latipes

<400>  44

Met Asn Leu Ser Tyr Leu Val Ala Cys Gly Leu Leu Val Thr Phe Leu 
1               5                   10                  15      


Ser Asp Lys Met Asp Ala Gln Pro Leu Thr Pro Ala Gln Gln Lys Ser 
            20                  25                  30          


Leu Arg Ser Leu Leu Gly Glu Glu Leu Ala Glu Phe Leu Glu Ser Gly 
        35                  40                  45              


Glu Asn Glu Asn Arg Leu Asp Asp Val Arg Ser Arg Met Arg Leu Leu 
    50                  55                  60                  


Arg Asp Leu Arg Val Asp Thr Arg Ala Arg Gly Met Trp Ala Arg Leu 
65                  70                  75                  80  


Leu Asn Asp Gln Pro Ala Ser Arg Arg His Lys Ser Gly Ser Lys Lys 
                85                  90                  95      


Gly Gly Ser Thr Ser Arg Ser Gly Cys Phe Gly His Lys Met Asp Arg 
            100                 105                 110         


Ile Gly Thr Ile Ser Gly Met Gly Cys 
        115                 120     


<210>  45
<211>  120
<212>  PRT
<213>  Takifugu rubripes

<400>  45

Met Asn Leu Ser Tyr Leu Val Ala Cys Gly Leu Met Ile Thr Leu Leu 
1               5                   10                  15      


Ser Val Arg Met Gly Ala Lys Pro Leu Ser Gln Ala Gln Gln Lys Ser 
            20                  25                  30          


Phe Arg Ser Leu Leu Gly Glu Glu Leu Ala Glu Phe Leu Glu Ser Glu 
        35                  40                  45              


Glu Lys Glu Arg Arg Leu Asp Ala Val Arg Ser Arg Leu Arg Leu Leu 
    50                  55                  60                  


Arg Asp Leu Arg Met Asp Thr Arg Ala Arg Gly Val Trp Ala Arg Leu 
65                  70                  75                  80  


Leu Asn Asp Gln Pro Val Pro Arg Arg His Lys Thr Gly Ile Lys Lys 
                85                  90                  95      


Gly Gly Ser Ser Arg Ser Gly Cys Phe Gly His Lys Met Asp Arg Ile 
            100                 105                 110         


Gly Thr Ile Ser Gly Met Gly Cys 
        115                 120 


<210>  46
<211>  121
<212>  PRT
<213>  Esox lucius

<400>  46

Met Asn Ile Ser Tyr Leu Val Ala Cys Gly Leu Met Ile Thr Leu Leu 
1               5                   10                  15      


Ser Val Arg Ser Gly Ala Lys Pro Leu Thr Ala Ala Gln Gln Lys Ser 
            20                  25                  30          


Leu Arg Asn Leu Leu Gly Glu Glu Leu Ser Glu Phe Leu Ala Ser Gly 
        35                  40                  45              


Glu Arg Glu Arg Arg Leu Asp Thr Val Arg Ser Arg Val Arg Leu Leu 
    50                  55                  60                  


Arg Asp Leu Arg Met Asp Thr Arg Ala Lys Gly Met Trp Ala Arg Leu 
65                  70                  75                  80  


Leu Asn Asp Gln Pro Asn Ala Arg Arg His Lys Gln Asn Ser Lys Lys 
                85                  90                  95      


Gly Thr Val Pro Arg Ser Gly Cys Phe Gly Gln Lys Leu Asp Arg Ile 
            100                 105                 110         


Gly Thr Leu Ser Gly Met Gly Cys Asn 
        115                 120     


<210>  47
<211>  120
<212>  PRT
<213>  Anguilla japonica

<400>  47

Met Asn Val Ser Gln Leu Met Val Cys Gly Leu Leu Met Ala Leu Phe 
1               5                   10                  15      


Ser Phe Ser Thr Glu Ala Lys Ser Leu Ile Pro Ala Gln Glu Lys Ser 
            20                  25                  30          


Leu Arg Asn Leu Leu Gly Glu Glu Leu Ser Glu Tyr Leu Ala Ser Gly 
        35                  40                  45              


Glu Arg Glu Arg Asn Leu Glu Ser Ala Arg Ser Arg Leu Leu Arg Asp 
    50                  55                  60                  


Leu Arg Leu Asn Thr Arg Ala Arg Gly Met Trp Ser Arg Ile Met Asn 
65                  70                  75                  80  


Asp Gln Pro Ala Ser Arg Lys Gln Lys Thr Gly Val Lys Lys Gly Ala 
                85                  90                  95      


Ser Thr Pro Ala Arg Gly Gly Cys Phe Gly His Lys Leu Asp Arg Ile 
            100                 105                 110         


Ser Thr Leu Ser Gly Met Gly Cys 
        115                 120 


<210>  48
<211>  118
<212>  PRT
<213>  Actinopterygii

<400>  48

Met Asn Ile Ser His Leu Val Ala Cys Gly Leu Leu Val Ala Leu Leu 
1               5                   10                  15      


Thr Val Thr Met Glu Ala Lys Pro Leu Thr Gln Ser Gln Gln Lys Ser 
            20                  25                  30          


Leu Arg Asn Leu Leu Gly Glu Glu Leu Ser Ala Tyr Leu Thr Ser Asp 
        35                  40                  45              


Glu Gln Glu Ser Gly Ser Glu Asn Leu Arg Ser Arg Ala Arg Leu Leu 
    50                  55                  60                  


Arg Asp Leu Arg Leu Asp Ile Arg Ala Lys Ala Ala Trp Ala Arg Leu 
65                  70                  75                  80  


Leu Asn Asp His Pro Asn Pro Arg Lys Ser Lys Gly Ile Asn Lys Lys 
                85                  90                  95      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            100                 105                 110         


Met Ser Gly Leu Gly Cys 
        115             


<210>  49
<211>  118
<212>  PRT
<213>  Rana catesbeiana

<400>  49

Met His Phe Cys His Ile Val Gly Trp Gly Leu Val Leu Ala Val Leu 
1               5                   10                  15      


Tyr Leu Arg Thr Glu Ala Lys Pro Val Ala Gln Ala His Gln Lys Ser 
            20                  25                  30          


Leu Arg Ala Leu Leu Gly Glu Glu Leu Ala Glu Tyr Leu Val Ser Gly 
        35                  40                  45              


Glu Arg Gly Glu Arg Ser Ile Asp Pro Lys Thr Arg Ala Arg Leu Leu 
    50                  55                  60                  


Arg Asp Ile Arg Ala Asp Thr Arg Ser Arg Ala Ala Trp Thr Arg Leu 
65                  70                  75                  80  


Leu Asn Glu His Pro Asn Ser Arg Lys Ile Lys Gly Ile Asn Lys Lys 
                85                  90                  95      


Gly Thr Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ala 
            100                 105                 110         


Met Ser Gly Leu Gly Cys 
        115             


<210>  50
<211>  193
<212>  PRT
<213>  Trimeresurus flavoviridis

<400>  50

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Ser Leu Asp Gly Lys Pro Val His Gln Ser Lys Pro Gly 
            20                  25                  30          


Arg Ser Pro Pro Ile Ser Pro Leu Ser Ala Gln Gln Trp Met Pro Glu 
        35                  40                  45              


Gly Arg Pro Pro His Pro Ile Pro Pro Leu Ser Val Gln Gln Trp Ser 
    50                  55                  60                  


Gln Gly Arg Pro Arg Ser Glu Val Pro Pro Val Val Val Gln Pro His 
65                  70                  75                  80  


Glu Ser Pro Ala Gly Gly Thr Thr Ala Phe Arg Glu Glu Leu Ser Pro 
                85                  90                  95      


Gly Pro Glu Ala Ala Ser Gly Pro Ala Ala Pro His Arg Leu Pro Lys 
            100                 105                 110         


Ser Lys Gly Ala Ser Ala Thr Ser Ala Ala Ser Arg Pro Met Arg Asp 
        115                 120                 125             


Leu Arg Thr Asp Gly Lys Gln Glu Arg Gln Lys Trp Gly Arg Met Val 
    130                 135                 140                 


Gln Pro Asp His His Ala Ala Pro Gly Gly Gly Gly Gly Gly Gly Gly 
145                 150                 155                 160 


Gly Ala Arg Arg Met Lys Gly Leu Ala Lys Lys Ala Met Gly Lys Gly 
                165                 170                 175     


Cys Phe Gly His Lys Leu Asp Arg Ile Gly Ser Thr Ser Gly Leu Gly 
            180                 185                 190         


Cys 
    


<210>  51
<211>  210
<212>  PRT
<213>  Trimeresurus gramineus

<400>  51

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Ser Leu Asp Gly Lys Pro Val Gln Glu Lys Pro Gly Arg 
            20                  25                  30          


Ser Pro Pro Ile Ser Pro Leu Leu Val Pro Pro Pro Pro Pro Pro Pro 
        35                  40                  45              


His Trp Pro Pro Pro His His Ile Pro Pro Leu Ser Val Gln Lys Phe 
    50                  55                  60                  


Pro Pro Gly Trp Lys Pro Thr His Pro His His Ile Pro Pro Leu Glu 
65                  70                  75                  80  


Val Gln Gln Trp Ser Gln Gly Gly Pro Arg Ser Glu Leu Val Gln Pro 
                85                  90                  95      


His Glu Ser Pro Ala Gly Gly Thr Thr Ala Phe Arg Glu Glu Leu Ser 
            100                 105                 110         


Leu Gly Pro Glu Ala Ala Ser Gly Pro Ala Ala Pro Gln Arg Leu Pro 
        115                 120                 125             


Lys Arg Lys Gly Ala Ser Ala Thr Ser Ala Ala Ser Arg Ser Met Arg 
    130                 135                 140                 


Asp Leu Arg Ala Asp Gly Lys Gln Ala Arg Gln Lys Trp Gly Arg Met 
145                 150                 155                 160 


Val Gln Pro Asp His His Ala Ala Pro Gly Gly Gly Gly Gly Gly Gly 
                165                 170                 175     


Gly Gly Ala Arg Arg Leu Lys Gly Leu Ala Lys Lys Ala Val Gly Lys 
            180                 185                 190         


Gly Cys Phe Gly Leu Pro Leu Asp Arg Ile Gly Ser Met Ser Gly Met 
        195                 200                 205             


Gly Cys 
    210 


<210>  52
<211>  256
<212>  PRT
<213>  Bothrops jararaca

<400>  52

Met Val Leu Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Ser Val Asp Gly Lys Pro Val Gln Gln Trp Ala Gln Ser 
            20                  25                  30          


Trp Pro Gly Pro Asn Ile Pro Pro Leu Lys Val Gln Gln Trp Ala Gln 
        35                  40                  45              


Gly Gly Trp Pro Arg Pro Gly Pro Glu Ile Pro Pro Leu Thr Val Gln 
    50                  55                  60                  


Gln Trp Ala Gln Asn Trp Pro His Pro Gln Ile Pro Pro Leu Thr Val 
65                  70                  75                  80  


Gln Gln Trp Ala Gln Gly Arg Ala Pro Gly Pro Pro Ile Pro Pro Leu 
                85                  90                  95      


Thr Val Gln Gln Trp Ala Gln Gly Arg Ala Pro His Pro Pro Ile Pro 
            100                 105                 110         


Pro Ala Pro Leu Gln Lys Trp Ala Pro Leu Gln Lys Trp Ala Pro Leu 
        115                 120                 125             


Leu Gln Pro His Glu Ser Pro Ala Ser Gly Thr Thr Ala Leu Arg Glu 
    130                 135                 140                 


Glu Leu Ser Leu Gly Pro Glu Ala Ala Ser Gly Val Pro Ser Ala Gly 
145                 150                 155                 160 


Ala Glu Val Gly Arg Ser Gly Ser Lys Ala Pro Ala Ala Pro His Arg 
                165                 170                 175     


Leu Ser Lys Ser Lys Gly Ala Ala Ala Thr Arg Pro Met Arg Asp Leu 
            180                 185                 190         


Arg Pro Asp Gly Lys Gln Ala Arg Gln Asn Trp Gly Arg Met Ala His 
        195                 200                 205             


His Asp His His Ala Ala Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
    210                 215                 220                 


Ala Arg Arg Leu Lys Gly Leu Ala Lys Lys Gly Ala Ala Lys Gly Cys 
225                 230                 235                 240 


Phe Gly Leu Lys Leu Asp Arg Ile Gly Thr Met Ser Gly Leu Gly Cys 
                245                 250                 255     


<210>  53
<211>  265
<212>  PRT
<213>  Bothrops jararaca

<400>  53

Met Val Leu Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Ser Val Asp Gly Lys Pro Val Gln Gln Trp Ala Gln Gly 
            20                  25                  30          


Gly Trp Pro Arg Pro Gly Pro Glu Ile Pro Pro Leu Lys Val Gln Gln 
        35                  40                  45              


Trp Ala Gln Gly Gly Trp Pro Arg Pro Gly Pro Glu Ile Pro Pro Leu 
    50                  55                  60                  


Thr Val Gln Gln Trp Ala Gln Asn Trp Pro His Pro Gln Ile Pro Pro 
65                  70                  75                  80  


Leu Thr Val Gln Gln Trp Ala Gln Trp Gly Arg Pro Pro Gly Pro Pro 
                85                  90                  95      


Ile Pro Pro Leu Thr Val Gln Gln Trp Ala Gln Ala Arg Pro Pro His 
            100                 105                 110         


Pro Pro Ile Pro Pro Ala Pro Leu Gln Lys Trp Ala Pro Val Gln Lys 
        115                 120                 125             


Trp Ala Pro Leu Leu Gln Pro His Glu Ser Pro Ala Ser Gly Thr Thr 
    130                 135                 140                 


Ala Leu Arg Glu Glu Leu Ser Leu Gly Pro Glu Ala Ala Ser Gly Val 
145                 150                 155                 160 


Pro Ser Ala Gly Ala Glu Val Gly Arg Ser Gly Ser Lys Ala Pro Ala 
                165                 170                 175     


Ala Pro His Arg Leu Ser Lys Ser Lys Gly Ala Ala Ala Thr Ser Ala 
            180                 185                 190         


Ala Ser Arg Pro Met Arg Asp Leu Arg Pro Asp Gly Lys Gln Ala Arg 
        195                 200                 205             


Gln Asn Trp Gly Arg Met Val His His Asp His His Ala Ala Val Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Arg Arg Leu Lys Gly Leu 
225                 230                 235                 240 


Ala Lys Lys Gly Ala Ala Lys Gly Cys Phe Gly Leu Lys Val Asp Arg 
                245                 250                 255     


Ile Gly Thr Met Ser Gly Leu Gly Cys 
            260                 265 


<210>  54
<211>  265
<212>  PRT
<213>  Bothrops insularis

<400>  54

Met Val Leu Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Ser Val Asp Gly Lys Pro Val Gln Gln Trp Ala Gln Gly 
            20                  25                  30          


Gly Trp Pro Arg Pro Gly Pro Glu Ile Pro Pro Leu Lys Val Gln Gln 
        35                  40                  45              


Trp Ala Gln Gly Gly Trp Pro Arg Pro Gly Pro Glu Ile Pro Pro Leu 
    50                  55                  60                  


Thr Val Gln Gln Trp Ala Gln Asn Trp Pro His Pro Gln Ile Pro Pro 
65                  70                  75                  80  


Leu Thr Val Gln Gln Trp Ala Gln Leu Gly Pro Pro Pro Arg Pro Gln 
                85                  90                  95      


Ile Pro Pro Leu Glu Val Gln Gln Trp Ala Gln Gly Arg Ala Pro His 
            100                 105                 110         


Pro Pro Ile Pro Pro Ala Pro Leu Gln Lys Trp Ala Pro Val Gln Lys 
        115                 120                 125             


Trp Ala Pro Leu Leu Gln Pro His Glu Ser Pro Ala Ser Gly Thr Thr 
    130                 135                 140                 


Ala Leu Arg Glu Glu Leu Ser Leu Gly Pro Glu Ala Ala Ser Gly Val 
145                 150                 155                 160 


Pro Ser Ala Gly Ala Glu Val Gly Arg Ser Gly Ser Lys Ala Pro Ala 
                165                 170                 175     


Ala Pro His Arg Leu Ser Lys Ser Lys Gly Ala Ala Ala Thr Ser Ala 
            180                 185                 190         


Ala Ser Arg Pro Met Arg Asp Leu Arg Pro Asp Gly Lys Gln Ala Arg 
        195                 200                 205             


Gln Asn Trp Gly Arg Met Val His His Asp His His Ala Ala Val Gly 
    210                 215                 220                 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Arg Arg Leu Lys Gly Leu 
225                 230                 235                 240 


Ala Lys Lys Gly Ala Ala Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Thr Met Ser Gly Leu Gly Cys 
            260                 265 


<210>  55
<211>  181
<212>  PRT
<213>  Crotalus durissus terrificus

<400>  55

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Val Ser Leu Asp Gly Lys Pro Leu Gln Gln Trp Ser Gln Arg 
            20                  25                  30          


Trp Pro His Leu Glu Ile Pro Pro Leu Val Val Gln Asn Trp Lys Ser 
        35                  40                  45              


Pro Thr Gln Leu Gln Ala Arg Glu Ser Pro Ala Gly Gly Thr Thr Ala 
    50                  55                  60                  


Leu Arg Glu Glu Leu Ser Leu Gly Pro Glu Ala Ala Leu Asp Thr Pro 
65                  70                  75                  80  


Pro Ala Gly Pro Asp Gly Gly Pro Arg Gly Ser Lys Ala Ala Ala Ala 
                85                  90                  95      


Ala Pro Gln Arg Leu Ser Lys Ser Lys Gly Ala Ser Ala Thr Ser Ala 
            100                 105                 110         


Ala Ser Arg Asp Leu Arg Thr Asp Gly Lys Gln Ala Arg Gln Asn Trp 
        115                 120                 125             


Gly Arg Leu Val Ser Pro Asp His His Ser Ala Ala Gly Gly Gly Cys 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ala Arg Arg Leu Lys Gly Leu Ala Lys Lys Arg 
145                 150                 155                 160 


Ala Gly Asn Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
                165                 170                 175     


Ser Gly Leu Gly Cys 
            180     


<210>  56
<211>  181
<212>  PRT
<213>  Crotalus durissus collilineatus

<400>  56

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Val Ser Leu Asp Gly Lys Pro Leu Gln Gln Trp Ser Gln Arg 
            20                  25                  30          


Trp Pro His Leu Glu Ile Pro Pro Leu Val Val Gln Asn Trp Lys Ser 
        35                  40                  45              


Pro Thr Gln Leu Gln Ala Arg Glu Ser Pro Ala Gly Gly Thr Thr Ala 
    50                  55                  60                  


Leu Arg Glu Glu Leu Ser Leu Gly Pro Glu Ala Ala Leu Asp Thr Pro 
65                  70                  75                  80  


Pro Ala Gly Pro Asp Gly Gly Pro Arg Gly Ser Lys Ala Ala Ala Ala 
                85                  90                  95      


Ala Pro Gln Arg Leu Ser Lys Ser Lys Gly Ala Ser Ala Thr Ser Ala 
            100                 105                 110         


Ala Ser Arg Asp Leu Arg Thr Asp Gly Lys Gln Ala Arg Gln Asn Trp 
        115                 120                 125             


Gly Arg Leu Val Ser Pro Asp His His Ser Ala Ala Gly Gly Gly Gly 
    130                 135                 140                 


Gly Gly Gly Gly Gly Ala Arg Arg Leu Lys Gly Leu Ala Lys Lys Arg 
145                 150                 155                 160 


Ala Gly Asn Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
                165                 170                 175     


Ser Gly Leu Gly Cys 
            180     


<210>  57
<211>  201
<212>  PRT
<213>  Sistrurus catenatus edwardsii

<400>  57

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Val Ser Leu Asp Gly Lys Pro Val Gln Gln Trp Ser Gln Asn 
            20                  25                  30          


Trp Pro Gly Pro Lys Val Pro Pro Leu Val Val Gln Gln Trp Ser Gln 
        35                  40                  45              


Asn Trp Pro His Pro Gln Ile Pro Pro Leu Val Val Gln Asn Trp Lys 
    50                  55                  60                  


Ser Pro Thr Gln Leu Gln Pro Arg Glu Ser Pro Ala Gly Gly Thr Thr 
65                  70                  75                  80  


Ala Leu Arg Glu Glu Leu Ser Leu Gly Pro Asp Ala Ala Leu Asp Thr 
                85                  90                  95      


Pro Pro Ala Gly Pro Asp Val Gly Pro Arg Gly Ser Lys Ala Ala Ala 
            100                 105                 110         


Ala Pro Gln Arg Leu Ser Lys Ser Lys Gly Ala Ser Ala Thr Ser Thr 
        115                 120                 125             


Ala Ser Arg Pro Met Arg Asp Leu Arg Thr Asp Gly Lys Gln Ala Arg 
    130                 135                 140                 


Gln Asn Trp Gly Arg Met Leu Asn Pro Asp His His Ser Ala Pro Gly 
145                 150                 155                 160 


Gly Gly Gly Gly Gly Gly Gly Gly Gly Ala Arg Arg Leu Lys Gly Leu 
                165                 170                 175     


Ala Lys Lys Arg Ala Gly Ser Gly Cys Phe Gly Leu Lys Leu Asp Arg 
            180                 185                 190         


Ile Gly Ser Met Ser Gly Leu Gly Cys 
        195                 200     


<210>  58
<211>  239
<212>  PRT
<213>  Lachesis muta muta

<400>  58

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Val Ser Leu Asp Gly Lys Pro Val Gln Gln Trp Ser His Lys 
            20                  25                  30          


Gly Trp Pro Pro Arg Pro Gln Ile Pro Pro Leu Val Val Gln Gln Trp 
        35                  40                  45              


Ser Gln Lys Pro Trp Pro Pro Gly His His Ile Pro Pro Val Val Val 
    50                  55                  60                  


Gln Glu Trp Pro Pro Gly His His Ile Pro Pro Leu Val Val Gln Gln 
65                  70                  75                  80  


Trp Ser Gln Lys Lys Trp Pro Pro Gly His His Ile Pro Pro Leu Val 
                85                  90                  95      


Val Gln Lys Trp Asp Pro Pro Pro Ile Ser Pro Pro Leu Leu Lys Pro 
            100                 105                 110         


His Glu Ser Pro Ala Gly Gly Thr Thr Ala Leu Arg Glu Glu Leu Ser 
        115                 120                 125             


Leu Gly Pro Glu Ala Ala Leu Asp Thr Pro Pro Ala Gly Pro Asp Val 
    130                 135                 140                 


Gly Pro Arg Gly Ser Lys Ala Pro Ala Ala Pro His Arg Leu Pro Lys 
145                 150                 155                 160 


Ser Lys Gly Ala Ser Ala Thr Ser Ala Ala Ser Arg Pro Met Arg Asp 
                165                 170                 175     


Leu Arg Thr Asp Gly Lys Gln Ala Arg Gln Asn Trp Gly Arg Met Met 
            180                 185                 190         


Asn Pro Asp His His Ala Val Gly Gly Gly Gly Gly Gly Gly Gly Ala 
        195                 200                 205             


Arg Arg Leu Lys Gly Leu Ala Lys Lys Arg Val Gly Asp Gly Cys Phe 
    210                 215                 220                 


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
225                 230                 235                 


<210>  59
<211>  263
<212>  PRT
<213>  Agkistrodon halys blomhoffi

<400>  59

Met Phe Val Ser Arg Leu Ala Ala Ser Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Met Ala Leu Ser Leu Asp Gly Lys Pro Val Gln Gln Trp Ser Gln Gly 
            20                  25                  30          


Arg Pro Pro Gly Pro Pro Ile Pro Arg Leu Val Val Gln Gln Trp Ser 
        35                  40                  45              


Gln Gly Leu Pro Pro Gly Pro Pro Ile Pro Arg Leu Val Val Gln Gln 
    50                  55                  60                  


Trp Ser Gln Gly Leu Pro Pro Gly Pro Pro Ile Pro Pro Leu Val Val 
65                  70                  75                  80  


Gln Gln Trp Ser Gln Gly Leu Pro Pro Arg Pro Lys Ile Pro Pro Leu 
                85                  90                  95      


Val Val Gln Gln Trp Ser Gln Gly Leu Pro Pro Arg Pro Lys Ile Pro 
            100                 105                 110         


Pro Leu Val Val Gln Lys Trp Asp Pro Pro Pro Val Ser Pro Pro Leu 
        115                 120                 125             


Leu Leu Gln Pro His Glu Ser Pro Ala Gly Gly Thr Thr Ala Leu Arg 
    130                 135                 140                 


Glu Glu Leu Ser Leu Gly Pro Glu Ala Ala Ser Gly Pro Ala Ala Ala 
145                 150                 155                 160 


Gly Ala Asp Gly Gly Arg Ser Gly Ser Lys Ala Pro Ala Ala Leu His 
                165                 170                 175     


Arg Leu Ser Lys Ser Lys Gly Ala Ser Ala Thr Ser Ala Ser Ala Ser 
            180                 185                 190         


Arg Pro Met Arg Asp Leu Arg Thr Asp Gly Lys Gln Ala Arg Gln Asn 
        195                 200                 205             


Trp Ala Arg Met Val Asn Pro Asp His His Ala Val Gly Gly Cys Cys 
    210                 215                 220                 


Cys Gly Gly Gly Gly Gly Gly Ala Arg Arg Leu Lys Gly Leu Val Lys 
225                 230                 235                 240 


Lys Gly Val Ala Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
                245                 250                 255     


Thr Met Ser Gly Leu Gly Cys 
            260             


<210>  60
<211>  164
<212>  PRT
<213>  Philodryas olfersii

<400>  60

Met Val Ala Ser Arg Leu Ala Ala Gly Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Leu Ala Leu Ala Leu Asp Gly Lys Pro Ala Pro Pro Gln Pro Leu Arg 
            20                  25                  30          


Lys Ala Pro Ala Gly Gly Thr Thr Ala Trp Arg Arg Glu Leu Thr Glu 
        35                  40                  45              


Gln Pro Glu Gly Ala Ser Arg Pro Ala Ala Gly Gly Gly Gly Gly Gly 
    50                  55                  60                  


Gly Arg Ser Gly Ser Lys Ala Ala Asn Ala Ala Pro Thr Ala Pro Lys 
65                  70                  75                  80  


Ser Lys Gly Gly Ala Ala Ala Ala Ala Ala Ala Ala Ala Arg Leu Met 
                85                  90                  95      


Arg Asp Leu Arg Pro Asp Ser Lys Gln Ala Arg Ala Ala Trp Gly Arg 
            100                 105                 110         


Met Val His Pro Glu His His Ala Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Gly Gly Ala Ser Arg Arg Leu Lys Gly Val Ala Lys Lys Gly Leu 
    130                 135                 140                 


Gly Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
145                 150                 155                 160 


Gly Leu Gly Cys 
                


<210>  61
<211>  161
<212>  PRT
<213>  Rhabdophis tigrinus tigrinus

<400>  61

Met Phe Ala Ser Arg Leu Ala Ala Leu Gly Leu Leu Leu Leu Ala Leu 
1               5                   10                  15      


Val Leu Asp Gly Lys Pro Ala Pro Pro Pro Gln Pro Leu Arg Lys Ala 
            20                  25                  30          


Pro Ala Gly Gly Thr Thr Ala Leu Gln Arg Gln Leu Thr Glu Gln Gln 
        35                  40                  45              


Gln Gln Gln Gln Gln Ala Glu Gly Ser Ser Gly Pro Ala Ala Gly Gly 
    50                  55                  60                  


Gly Gly Gly Arg Ser Gly Ser Lys Thr Ala Asn Ala Ala Pro Thr Ala 
65                  70                  75                  80  


Pro Lys Ser Lys Gly Ala Ala Ala Ser Ala Ala Ser Arg Leu Leu Arg 
                85                  90                  95      


Asp Leu Arg Pro Asp Gly Lys Gln Ser Arg Ala Ala Trp Gly Arg Met 
            100                 105                 110         


Val His Pro Glu His His Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        115                 120                 125             


Gly Ser Arg Arg Leu Lys Gly Leu Pro Lys Lys Gly Leu Gly Ser Gly 
    130                 135                 140                 


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
145                 150                 155                 160 


Cys 
    


<210>  62
<211>  221
<212>  PRT
<213>  Bothrops jararacussu

<400>  62

His Glu Lys Pro Ser Arg Ser Gly Ala Lys Ser Ala Ala Val Gly Ala 
1               5                   10                  15      


Lys Leu Ala Ala Ser Ser Asp Ser Ala Ala Asp Glu Cys Ser Ser Gly 
            20                  25                  30          


Arg Lys Gly Glu Pro Pro Gly Pro Pro Ile Pro Pro Leu Thr Val Gln 
        35                  40                  45              


Gln Trp Ala Gln Ala Arg Pro Pro His Pro Pro Ile Pro Pro Ala Pro 
    50                  55                  60                  


Leu Gln Lys Trp Ala Pro Val Gln Lys Trp Ala Pro Val Gln Lys Trp 
65                  70                  75                  80  


Ala Pro Leu Leu Gln Pro His Glu Ser Pro Ala Gly Gly Thr Thr Ala 
                85                  90                  95      


Leu Arg Glu Glu Leu Ser Leu Gly Pro Glu Ala Ala Ser Gly Val Pro 
            100                 105                 110         


Ser Ala Gly Ala Glu Gly Arg Ala Gln Arg Leu Glu Gly Ala Arg Cys 
        115                 120                 125             


Thr Pro Ser Ala Val Glu Glu Gln Arg Gly Gly Gly Asp Leu Gly Gly 
    130                 135                 140                 


Val Ala Ala Asp Ala Gly Leu Ala Pro Arg Arg Gln Ala Gly Ala Ala 
145                 150                 155                 160 


Glu Leu Gly Pro Asp Gly Ala Pro Arg Pro Pro Arg Pro Pro Arg Ser 
                165                 170                 175     


Gly Arg Arg Ala Ala Ala Ala Ala Ala Ala Glu Arg Gly Ala Arg Arg 
            180                 185                 190         


Leu Lys Gly Leu Ala Lys Lys Gly Ala Ala Lys Gly Cys Phe Gly Leu 
        195                 200                 205             


Lys Leu Asp Arg Ile Gly Thr Met Ser Gly Leu Gly Cys 
    210                 215                 220     


<210>  63
<211>  116
<212>  PRT
<213>  Petromyzontidae

<400>  63

Ser Gly Ser Glu Pro Trp Glu Gly Gly Phe Leu Pro Arg Val Ser Ser 
1               5                   10                  15      


Ser Ser Ser Ser Ser Ser Gly Glu Val Glu Pro Leu Ala Glu Val Thr 
            20                  25                  30          


Ala Thr Gly Gly Val Ser Gly Gly Val Ser Gly Gly Val Leu Gly Gly 
        35                  40                  45              


Thr Pro Trp Val Gly Pro Arg Gly His Gln Arg Pro Ser Arg Gly Leu 
    50                  55                  60                  


Ala Glu Gly Gly Ser Gln Val Ser Gly Gly Val Trp Gln Arg Leu Phe 
65                  70                  75                  80  


Asn Asp Phe Val Ser Asn Gln Arg Arg Phe Arg Gly Arg Thr Lys Lys 
                85                  90                  95      


Gly Lys Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ser Met Ser 
            100                 105                 110         


Gly Leu Gly Cys 
        115     


<210>  64
<211>  148
<212>  PRT
<213>  Lampetra japonica

<400>  64

Met Lys Leu Gln Leu Leu Met Met Val Val Val Val Gly Ser Trp Thr 
1               5                   10                  15      


Phe Leu Gly Val Gly Ala Lys Pro Leu Thr Ser Tyr Glu Leu Tyr Asp 
            20                  25                  30          


Asp Ala Gly Ser Glu Pro Trp Glu Gly Gly Phe Leu Pro Arg Ile Ser 
        35                  40                  45              


Ser Ser Ser Ser Ser Ser Ala Glu Arg Leu Ala Asp Ala Thr Val Thr 
    50                  55                  60                  


Arg His Gly Gly Gly Gly Gly Gly Gly Gly Asp Asp Gly Thr Ser Trp 
65                  70                  75                  80  


Glu Leu Pro Gln Gly Pro Pro Gly Pro Pro Arg Ser Ser Arg Gly Leu 
                85                  90                  95      


Ala Glu Gly Gly Ser Gln Val Ser Gly Gly Val Trp Gln Arg Leu Phe 
            100                 105                 110         


Asn Asp Phe Val Ser Asn Gln Arg Arg Phe Arg Gly Arg Thr Lys Lys 
        115                 120                 125             


Gly Lys Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ser Met Ser 
    130                 135                 140                 


Gly Leu Gly Cys 
145             


<210>  65
<211>  133
<212>  PRT
<213>  Petromyzontidae

<400>  65

Met Arg Arg Gln Val Leu Val Met Val Val Met Val Val Val Met Val 
1               5                   10                  15      


Val Met Ser Gly Lys Ser Val Thr Ala Lys Pro Val Ala Ser Tyr Glu 
            20                  25                  30          


Leu Leu Asp Asp Thr Asn Ser Glu Pro Trp Glu Gly Gly Ser Leu Leu 
        35                  40                  45              


Pro Ser Leu Pro Ser Gln Gly Glu Gly Asp Ser His Pro Leu Ser Ala 
    50                  55                  60                  


Glu Gly Gly Pro Trp Glu Arg Gly Ser Gly Pro Gln Arg Ser Ser Arg 
65                  70                  75                  80  


Gly Ile Gly Gly Gly Ser Gln Val Ser Gly Glu Val Trp Gln Arg Leu 
                85                  90                  95      


Phe Asn Asp Phe Val Ser Asn Gln Arg Arg Phe Arg Gly Arg Thr Lys 
            100                 105                 110         


Lys Gly Lys Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ser Met 
        115                 120                 125             


Ser Gly Leu Gly Cys 
    130             


<210>  66
<211>  22
<212>  PRT
<213>  Gallus gallus

<400>  66

Gly Leu Ser Arg Ser Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  67
<211>  130
<212>  PRT
<213>  Gallus gallus

<400>  67

Met Lys Leu Leu Phe Cys Pro Gly Phe Phe Leu Leu Leu Ile Val Ser 
1               5                   10                  15      


Gln Lys Gln Ala Met Ala Lys Pro Ile Ser Ser Leu Gln Ser Leu Ser 
            20                  25                  30          


Met Leu Leu Asp Glu Glu Leu Gln His Pro Leu Val Ser Glu Glu Arg 
        35                  40                  45              


Asp Arg Glu Gln Asp Gly Ser Ile Pro Val Gly Ala Phe Asp Gln Glu 
    50                  55                  60                  


Asp Ala Glu Phe Gln Trp Thr Arg Asn Thr Arg Asp Gln Pro Ala Ser 
65                  70                  75                  80  


Thr Ser Thr Ala Asp Ser Asp Val Gln Arg Ile Leu Ser Asp Leu Leu 
                85                  90                  95      


Gly Leu Pro Gln Arg Tyr Gln Asn Arg Ser Lys Lys Gly Leu Ser Arg 
            100                 105                 110         


Ser Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        115                 120                 125             


Gly Cys 
    130 


<210>  68
<211>  129
<212>  PRT
<213>  Rana catesbeiana

<400>  68

Met Ser Tyr Lys Arg Gly Thr Cys Leu Gly Phe Ile Met Leu Leu Met 
1               5                   10                  15      


Val Ser His His His Thr Lys Gly Lys Pro Leu Ser Ser Leu Gln Asn 
            20                  25                  30          


Leu Ser Arg Leu Leu Glu Asp Asn Phe Glu Arg Ser Phe Gly Ser Asp 
        35                  40                  45              


Glu Ala Asp Gln Gln Leu Val Pro Thr Asp Ser Leu Asp Gln Leu Asp 
    50                  55                  60                  


Pro Glu Leu Gln Trp Asn Lys Asn Arg Leu Glu Gln Gly Asp Ser Pro 
65                  70                  75                  80  


His Val Asn Glu Met Thr Leu Gln Gln Leu Leu Asn Asp Pro Val Gly 
                85                  90                  95      


Thr Ser Arg Arg Tyr Arg Gln Arg Asn Lys Lys Gly Tyr Ser Arg Gly 
            100                 105                 110         


Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Phe Ser Gly Leu Gly 
        115                 120                 125             


Cys 
    


<210>  69
<211>  136
<212>  PRT
<213>  Triakis scyllium

<400>  69

Met Ser Gly Gln Thr Ser Phe Tyr Cys Gly Leu Leu Leu Val Leu Leu 
1               5                   10                  15      


Ile Gln Ala Gln Ala Arg Pro Arg Ser Asp Asp Ser Leu Gln Thr Leu 
            20                  25                  30          


Ser Arg Leu Leu Glu Asp Glu Tyr Gly His Tyr Leu Pro Ser Asp Glu 
        35                  40                  45              


Leu Asn Asn Glu Ala Gln Glu Met Ser Pro Ala Ala Ser Leu Pro Glu 
    50                  55                  60                  


Phe Asn Ala Asp Gln Ser Asp Leu Glu Leu Pro Trp Asp Arg Glu Ser 
65                  70                  75                  80  


Arg Glu Ile Gly Gly Arg Pro Phe Arg Gln Glu Ala Val Leu Ala Arg 
                85                  90                  95      


Leu Leu Lys Asp Leu Ser Asn Asn Pro Leu Arg Phe Arg Gly Arg Ser 
            100                 105                 110         


Lys Lys Gly Pro Ser Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile 
        115                 120                 125             


Gly Ala Met Ser Gly Leu Gly Cys 
    130                 135     


<210>  70
<211>  115
<212>  PRT
<213>  Scyliorhinus canicula

<400>  70

Arg Pro Arg Ser Asp Asp Ser Leu Gln Thr Leu Ser Arg Leu Leu Glu 
1               5                   10                  15      


Asp Glu Tyr Gly His Tyr Leu Pro Ser Asp Glu Leu Asn Asn Glu Ala 
            20                  25                  30          


Glu Glu Met Ser Pro Ala Ala Ser Leu Pro Glu Leu Asn Ala Asp Gln 
        35                  40                  45              


Ser Asp Leu Glu Leu Pro Trp Glu Arg Glu Ser Arg Glu Ile Gly Gly 
    50                  55                  60                  


Arg Pro Phe Arg Gln Glu Ala Val Leu Ala Arg Leu Leu Lys Asp Leu 
65                  70                  75                  80  


Ser Asn Asn Pro Leu Arg Phe Arg Gly Arg Ser Lys Lys Gly Pro Ser 
                85                  90                  95      


Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Met Ser Gly 
            100                 105                 110         


Leu Gly Cys 
        115 


<210>  71
<211>  135
<212>  PRT
<213>  Squalus acanthias

<400>  71

Met Ser Gly His Thr Ser Phe Tyr Cys Gly Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Ile Gln Val Gln Ala Arg Pro Arg Ala Asp Asp Ser Leu Gln Val Leu 
            20                  25                  30          


Ser Arg Leu Leu Glu Asp Glu Tyr Gly His Phe Asn Ser Glu Glu Leu 
        35                  40                  45              


Asn Asn Glu Ala Gln Glu Ile Ser Pro Ala Ala Ser Leu Pro Asp Leu 
    50                  55                  60                  


Asn Thr Asp Gln Ser Asp Leu Glu Leu Pro Trp Asp Arg Glu Ser Arg 
65                  70                  75                  80  


Glu Ile Gly Gly Arg Ser Phe Arg Gln Glu Ala Leu Leu Ala Arg Leu 
                85                  90                  95      


Leu Gln Asp Leu Ser Asn Asn Pro Leu Arg Phe Lys Gly Arg Ser Lys 
            100                 105                 110         


Lys Gly Pro Ser Arg Ser Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
        115                 120                 125             


Ala Met Ser Gly Leu Gly Cys 
    130                 135 


<210>  72
<211>  131
<212>  PRT
<213>  Chondrichthyes

<400>  72

Met Ser Gly Asn Thr Asn Phe Tyr Cys Gly Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Val Gln Gly Arg Pro Arg Ser Asp Asp Ser Leu Gln Ala Leu 
            20                  25                  30          


Thr Arg Leu Leu Glu Asp Glu Tyr Gly Gln Tyr Phe Thr Thr Glu Asp 
        35                  40                  45              


Leu Asn Asn Glu Ala Pro Glu Ile Pro Pro Ala Ala Ser Leu Pro Asp 
    50                  55                  60                  


Leu Asn Thr Asp Gln Ser Asp Leu Asp Leu Ser Trp Asp Arg Glu Ser 
65                  70                  75                  80  


Arg Glu Ile Ala Ser Arg Pro Ile Leu Ala Arg Ile Leu Lys Asp Leu 
                85                  90                  95      


Ser Asn Asn Pro Leu Arg Phe Arg Gly Arg Ser Lys Lys Gly Pro Ser 
            100                 105                 110         


Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  73
<211>  131
<212>  PRT
<213>  Chondrichthyes

<400>  73

Met Ser Gly Asn Thr Asn Phe Tyr Cys Gly Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Val Gln Gly Arg Pro Arg Ser Asp Asp Ser Leu Gln Ala Leu 
            20                  25                  30          


Thr Arg Leu Leu Glu Asp Glu Tyr Gly Gln Tyr Phe Thr Thr Glu Asp 
        35                  40                  45              


Leu Asn Asn Glu Ala Pro Glu Ile Pro Pro Ala Ala Ser Leu Pro Asp 
    50                  55                  60                  


Leu Asn Thr Asp Gln Ser Asp Leu Asp Leu Ser Trp Asp Arg Glu Ser 
65                  70                  75                  80  


Arg Glu Ile Ala Ser Arg Pro Ile Leu Ala Arg Ile Leu Lys Asp Leu 
                85                  90                  95      


Ser Asn Asn Pro Leu Arg Phe Arg Gly Arg Ser Lys Lys Gly Pro Ser 
            100                 105                 110         


Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  74
<211>  131
<212>  PRT
<213>  Chondrichthyes

<400>  74

Met Ser Gly Asn Thr Asn Phe Tyr Cys Gly Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Val Gln Gly Arg Pro Arg Ser Asp Asp Ser Leu Gln Ala Leu 
            20                  25                  30          


Thr Arg Leu Leu Glu Asp Glu Tyr Gly Gln Tyr Phe Thr Ser Glu Asp 
        35                  40                  45              


Leu Asn Asn Glu Ala Pro Glu Ile Pro Pro Ala Ala Ser Leu Pro Asp 
    50                  55                  60                  


Leu Asn Thr Asp Gln Pro Asp Phe Asp Leu Ser Trp Asp Arg Glu Ser 
65                  70                  75                  80  


Arg Glu Ile Ala Ser Arg Pro Ile Leu Ala Arg Ile Leu Lys Asp Leu 
                85                  90                  95      


Ser Asn Asn Pro Leu Arg Phe Arg Gly Arg Ser Lys Lys Gly Pro Ser 
            100                 105                 110         


Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  75
<211>  131
<212>  PRT
<213>  Dasyatis akajei

<400>  75

Met Ser Gly Asn Thr Asn Phe Tyr Cys Gly Leu Val Leu Leu Leu Leu 
1               5                   10                  15      


Leu Gln Val Gln Gly Arg Pro Arg Ser Asp Asp Ser Leu Gln Ala Leu 
            20                  25                  30          


Thr Arg Leu Leu Glu Asp Glu Tyr Gly Gln Tyr Phe Thr Ser Glu Asp 
        35                  40                  45              


Leu Asn Asn Glu Ala Pro Glu Met Ser Pro Ala Ala Ser Leu Pro Asp 
    50                  55                  60                  


Leu Asn Thr Glu Gln Ser Glu Thr Asp Leu Pro Trp Asp Arg Glu Ser 
65                  70                  75                  80  


Arg Glu Ile Ala Ser Arg Pro Ile Leu Ala Arg Ile Leu Lys Asp Leu 
                85                  90                  95      


Asn Asn Ile Pro Leu Arg Phe Arg Gly Arg Ser Lys Lys Gly Pro Ser 
            100                 105                 110         


Arg Gly Cys Phe Gly Val Lys Leu Asp Arg Ile Gly Ala Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  76
<211>  139
<212>  PRT
<213>  Callorhynchus milii

<400>  76

Met Asn Ala His Val Ser Phe Pro Cys Gly Leu Met Leu Leu Leu Leu 
1               5                   10                  15      


Ile Gln Val Gln Val Gln Ala Arg Pro Arg Thr Gly Val Asp Ser Leu 
            20                  25                  30          


Gln Ile Leu Ser Arg Leu Leu Glu Asp Glu Tyr Gly Pro Tyr Leu Ser 
        35                  40                  45              


Ser Glu Asp Ser Asp Met Glu Ala Glu Glu Ala Ser Arg Ala Gly Thr 
    50                  55                  60                  


Leu Arg Asp Leu Asn Leu Asp Gln Ala Asp Met Asp Leu Leu Trp Asp 
65                  70                  75                  80  


Arg Asp Ala Arg Asp Ile Gly Gly Arg Ser Phe Gln His Asp Gly Leu 
                85                  90                  95      


Leu Leu Arg Leu Leu Lys Asp Leu Thr Ile Ser Pro Leu Arg Phe Asn 
            100                 105                 110         


Gly Arg Ser Lys Lys Gly Pro Ser Arg Gly Cys Phe Gly Val Lys Leu 
        115                 120                 125             


Asp Arg Ile Gly Ala Met Ser Gly Leu Gly Cys 
    130                 135                 


<210>  77
<211>  112
<212>  PRT
<213>  Oryzias latipes

<400>  77

Met Ser Leu Arg Ala Phe Met Leu Cys Val Cys Leu Leu Leu Gln Ser 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ser Glu Leu Gln Asn Leu Glu Arg Leu Leu 
            20                  25                  30          


Gln Asp Gln Leu Ser Ser Thr Glu His Pro Glu Glu Asp Arg Leu Asp 
        35                  40                  45              


Arg Thr Arg Glu Glu Pro Gln Leu Gly Gly Ser Ser Ser Arg Glu Ala 
    50                  55                  60                  


Ala Asp Glu Ser Ala Leu Thr Arg Leu Phe Ala Asp Leu Leu Arg Thr 
65                  70                  75                  80  


Ser Lys Arg Ser Trp Gly Arg Tyr Lys Lys Gly Gly Met Arg Ser Cys 
                85                  90                  95      


Phe Gly Val Arg Leu Glu Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
            100                 105                 110         


<210>  78
<211>  112
<212>  PRT
<213>  Oryzias latipes

<400>  78

Met Ser Leu Arg Ala Phe Met Leu Cys Val Cys Leu Leu Leu Gln Ser 
1               5                   10                  15      


Val Gly Ala Arg Pro Ala Ser Glu Leu Gln Asn Leu Glu Arg Leu Leu 
            20                  25                  30          


Gln Asp Gln Leu Ser Ser Thr Glu His Pro Glu Glu Asp Arg Leu Asp 
        35                  40                  45              


Arg Thr Arg Glu Glu Pro Gln Leu Gly Gly Ser Ser Ser Arg Glu Ala 
    50                  55                  60                  


Ala Asp Glu Ser Ala Leu Thr Arg Leu Phe Ala Asp Leu Leu Arg Thr 
65                  70                  75                  80  


Ser Lys Arg Ser Trp Gly Arg Tyr Lys Lys Gly Gly Met Arg Ser Cys 
                85                  90                  95      


Phe Gly Val Arg Leu Glu Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
            100                 105                 110         


<210>  79
<211>  158
<212>  PRT
<213>  Takifugu rubripes

<400>  79

Met Ser Leu Asn Leu Pro Gly Tyr Ala Leu Phe Phe Ile Leu Leu Val 
1               5                   10                  15      


Ala Ser Ser Gly Ala Lys Pro Ala Pro Asp Leu Gln Ile Leu Glu Pro 
            20                  25                  30          


Pro Leu Ser Ser Leu Glu Glu Gln Glu Glu Met Gln Glu Glu Val Gln 
        35                  40                  45              


Glu Lys Val Gln Glu Gln Gln Glu Glu Val Gln Glu Lys Val Gln Glu 
    50                  55                  60                  


Gln Gln Glu Glu Val Gln Glu Gln Gln Glu Glu Val Gln Glu Gln Gln 
65                  70                  75                  80  


Glu Glu Gln Gln Glu Glu Val Gln Glu Arg Gly Arg Gly Thr Gly Asp 
                85                  90                  95      


Val Leu Leu Arg Ala Gln Leu Asp Ser Ser Thr Trp Ala Leu Gln Lys 
            100                 105                 110         


Asp Asp Val Leu Met Arg Leu Phe Lys Asp Leu Leu Arg Thr Ser Lys 
        115                 120                 125             


Arg Ser Arg Ser Arg Tyr Lys Lys Gly Gly Leu Arg Ser Cys Phe Gly 
    130                 135                 140                 


Val Arg Leu Ala Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
145                 150                 155             


<210>  80
<211>  128
<212>  PRT
<213>  Salmo salar

<400>  80

Met Lys Met Ile Ser Asn Ile Gln Phe Phe Cys Leu Thr Ala Leu Val 
1               5                   10                  15      


Leu Leu Asn Leu Val Gly Ala Asn Pro Met Ser Asn Leu Gln Ser Leu 
            20                  25                  30          


Lys Gln Leu Leu Glu Glu Glu Ser His Val Pro Tyr Tyr Ala Ser Asp 
        35                  40                  45              


Glu Met Gly Val Asp Gly Lys Asp Leu Asn Thr Glu Asn Ile Ala Glu 
    50                  55                  60                  


Glu Val Pro Pro Trp Asp Ser Glu Asp Ala Arg Asn Ser Ala Leu Thr 
65                  70                  75                  80  


Gly Lys Glu Asp Val Ile Ala Arg Leu Leu Asn Asp Ile Met Thr Thr 
                85                  90                  95      


Pro Lys Arg Ser Trp Ser Arg Phe Lys Lys Gly Gly Leu Arg Ser Cys 
            100                 105                 110         


Phe Gly Val Arg Leu Glu Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
        115                 120                 125             


<210>  81
<211>  126
<212>  PRT
<213>  Esox lucius

<400>  81

Met Ile Ser Asn Ile Gln Phe Cys Cys Leu Ser Val Leu Val Leu Leu 
1               5                   10                  15      


Asn Leu Val Gly Ala Lys Pro Val Ser Asn Leu Gln Ser Leu Lys Glu 
            20                  25                  30          


Phe Leu Glu Glu Ser Asn Val Pro Tyr Tyr Gly Ser Glu Glu Ser Glu 
        35                  40                  45              


Val Asp Asp Lys Asp Leu Asn Thr Glu Lys Glu Ala Phe Thr Gly Glu 
    50                  55                  60                  


Val Val Gln Pro Trp Leu Thr Glu Asp Arg Ser Ala Leu Thr Gly Lys 
65                  70                  75                  80  


Glu Asn Ala Val Ala Arg Leu Leu Ser Asp Ile Met Thr Thr Pro Lys 
                85                  90                  95      


Arg Ser Trp Gly Arg Phe Lys Lys Gly Gly Met Arg Ser Cys Phe Gly 
            100                 105                 110         


Val Arg Leu Glu Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  82
<211>  128
<212>  PRT
<213>  Anguilla japonica

<400>  82

Met Ile Ser Asn Ile Thr Ile Tyr Cys Ile Ser Ser Leu Leu Phe Leu 
1               5                   10                  15      


Asn Leu Val Gly Gly Lys Pro Val Ser Ser Leu Gln Ser Leu Lys Glu 
            20                  25                  30          


Leu Leu Glu Glu Glu Ser Asn Ala Pro Tyr Leu Asp Ser Glu Glu Ala 
        35                  40                  45              


Glu Val Gln Gly Lys Glu Met Asn Ala Glu Asn Ala Ala Phe Thr Lys 
    50                  55                  60                  


Ala Ser Leu His Ser Trp Asp Pro Asn Ser Arg Asp Ala Ala Leu Ser 
65                  70                  75                  80  


Ser Asn Glu Asn Ala Leu Val Arg Leu Leu Asn Asp Ile Leu Ser Ser 
                85                  90                  95      


Ser Lys Arg Ser Trp Ser Arg Phe Lys Lys Gly Gly Leu Arg Ser Cys 
            100                 105                 110         


Phe Gly Val Arg Leu Glu Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
        115                 120                 125             


<210>  83
<211>  128
<212>  PRT
<213>  Danio rerio

<400>  83

Met Ile Ala Asn Ile Ser Val Phe Cys Val Ser Ser Leu Leu Leu Leu 
1               5                   10                  15      


Asn Leu Val Gly Ala Lys Pro Val Ser Ser Leu Gln Ser Leu Lys Gln 
            20                  25                  30          


Leu Leu Asp Glu Glu Val Asn Lys Pro Phe Glu Glu Ser Gln Glu Ser 
        35                  40                  45              


Val Met Glu Gln Lys Asp Ala Thr Ala Glu Lys Ser Ala Leu Asp Glu 
    50                  55                  60                  


Arg Ala Glu Gln Leu Trp Glu Ser Asp Ala Arg Asn Ser Ala Leu Ala 
65                  70                  75                  80  


Gly Lys Tyr Gly Met Phe Glu Arg Leu Leu Gly Asp Leu Leu Ser Thr 
                85                  90                  95      


Ser Lys Arg Ser Trp Ser Arg Phe Lys Lys Gly Asp Leu Arg Ser Cys 
            100                 105                 110         


Phe Gly Val Arg Leu Glu Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
        115                 120                 125             


<210>  84
<211>  130
<212>  PRT
<213>  Actinopterygii

<400>  84

Met Val Ser Arg Leu Thr Val Tyr Cys Ala Leu Phe Ile Ile Val Leu 
1               5                   10                  15      


Ser Gln Val Ser Ala Lys Pro Val Ser Ser Leu Gln Ser Phe Ala Gln 
            20                  25                  30          


Leu Leu Glu Asp Glu Ser Asn His Pro Tyr Val Asp Ser Asp Asp Asp 
        35                  40                  45              


Thr Arg Gly Gly Leu Asp Val Ser Ala Glu Ile Ala Thr Asp Asp Ser 
    50                  55                  60                  


Glu Ala Asp Ile Pro Trp Asn His Asn Phe Arg Asp Leu Gln His Arg 
65                  70                  75                  80  


Gln Ala Ala His Ser Ser Arg Met Leu Lys Leu Leu Lys Asp Ile Leu 
                85                  90                  95      


Thr Ser Ser Gly Arg Ser Trp Asp Arg Glu Lys Lys Ser Gly Leu Arg 
            100                 105                 110         


Ser Cys Phe Gly Val Arg Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        115                 120                 125             


Gly Cys 
    130 


<210>  85
<211>  131
<212>  PRT
<213>  Oncorhynchus mykiss

<400>  85

Met Leu Tyr Pro Ala Leu Leu Cys Ala Ala Leu Leu Leu Ile Ala Pro 
1               5                   10                  15      


Leu Gly His Thr Glu Gly Arg Thr Leu Tyr Pro Ser Pro Asp Ala Ile 
            20                  25                  30          


Gln Phe Val Glu Gln Phe Leu Asp Arg Tyr Asn Asp Leu Thr Leu Asp 
        35                  40                  45              


Asp Leu Glu Asn Leu Val Ser Ser Gln Pro Glu Glu Pro Ser Ser Ala 
    50                  55                  60                  


Phe Thr Ser Gly Val Lys Ile Ala Glu Tyr Pro Lys Trp Ala Asp Ile 
65                  70                  75                  80  


Pro Ala Gln Gly Asp Ser Thr Trp Leu Arg Leu Leu Lys Gly Thr Leu 
                85                  90                  95      


Ala Asn Gln Lys Arg Ala Val Thr Asp Arg Ser Arg Arg Gly Trp Asn 
            100                 105                 110         


Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  86
<211>  131
<212>  PRT
<213>  Oncorhynchus mykiss

<400>  86

Met Leu Tyr Pro Ala Leu Leu Cys Ala Ala Leu Leu Leu Ile Ala Pro 
1               5                   10                  15      


Leu Gly His Thr Glu Gly Arg Thr Leu His Pro Ser Pro Asp Ala Ile 
            20                  25                  30          


Gln Phe Val Glu Gln Phe Leu Asp Arg Tyr Asn Asp Leu Thr Leu Asp 
        35                  40                  45              


Asp Leu Glu Asn Leu Val Ser Ser Gln Pro Glu Glu Pro Ser Ser Ala 
    50                  55                  60                  


Phe Thr Ser Gly Val Lys Val Ala Glu Tyr Pro Lys Trp Ala Asp Ile 
65                  70                  75                  80  


Pro Ala Gln Gly Asp Ser Thr Trp Leu Arg Leu Leu Lys Gly Thr Leu 
                85                  90                  95      


Ala Asn Gln Lys Arg Ala Val Met Asp Arg Ser Arg Arg Gly Trp Asn 
            100                 105                 110         


Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  87
<211>  132
<212>  PRT
<213>  Osmerus mordax

<400>  87

Met Leu Cys Pro Val Leu Leu Cys Ala Thr Leu Val Leu Leu Pro Pro 
1               5                   10                  15      


Leu Glu Leu Ser Glu Gly Arg Ala Leu His Pro Ser Pro Glu Gly Leu 
            20                  25                  30          


Gln Phe Val Glu Gln Phe Leu Glu Arg Cys Thr Asp Leu Leu Asn Leu 
        35                  40                  45              


Asp Asp Leu Glu Asn Ala Gly Ser Asn Gln Pro Glu Glu Pro Ser Asp 
    50                  55                  60                  


Tyr Ala Asn Gly Val Lys Val Ala Glu Tyr Pro Lys Trp Ala Asp Leu 
65                  70                  75                  80  


Pro Ala Ala Gln Glu Asp Ser Ala Trp Leu Arg Leu Leu Lys Ala Ala 
                85                  90                  95      


Leu Ala Asn Gln Lys Arg Ala Glu Pro Asp Arg Ser Arg Arg Ala Trp 
            100                 105                 110         


Asn Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
        115                 120                 125             


Gly Leu Gly Cys 
    130         


<210>  88
<211>  131
<212>  PRT
<213>  Oreochromis mossambicus

<400>  88

Met Leu Cys Pro Val Leu Leu Cys Ala Ala Leu Leu Leu Leu Thr Pro 
1               5                   10                  15      


Leu Glu Ile Thr Glu Ala Arg Ala Leu His Pro Ser Pro Asp Ala Val 
            20                  25                  30          


Gln Phe Val Glu Gln Phe Leu Glu Arg Tyr Asn Asp Leu Leu Thr Leu 
        35                  40                  45              


Asp Asp Leu Glu Asn Met Leu Asn Ser Gln Ala Glu Glu Gln Ser Thr 
    50                  55                  60                  


Leu Ser Ser Gly Ser Lys Ala Val Glu Tyr Pro Lys Trp Ala Asp Ala 
65                  70                  75                  80  


Gln Thr Gln Pro Glu Thr Pro Trp Leu Arg Leu Leu Lys Gly Ala Leu 
                85                  90                  95      


Ala Asn Gln Lys Arg Ala Glu Pro Asp Arg Ser Arg Arg Gly Trp Asn 
            100                 105                 110         


Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  89
<211>  131
<212>  PRT
<213>  Anoplopoma fimbria

<400>  89

Met Leu Cys Pro Val Leu Leu Cys Ala Thr Leu Leu Leu Leu Thr Pro 
1               5                   10                  15      


Leu Glu Ile Thr Glu Ala Arg Ala Leu His Pro Pro Pro Asp Ala Val 
            20                  25                  30          


Gln Phe Met Glu Gln Phe Leu Glu Arg Tyr Asn Asp Leu Leu Thr Leu 
        35                  40                  45              


Asp Asp Leu Glu Asn Leu Leu Asn Ser Gln Pro Glu Glu Gln Ser Thr 
    50                  55                  60                  


Phe Ser Ser Gly Val Lys Ala Ala Glu Tyr Pro Lys Trp Ala Asp Ala 
65                  70                  75                  80  


Gln Thr Gln Ala Glu Thr Pro Trp Leu Arg Leu Leu Lys Gly Ala Val 
                85                  90                  95      


Ala Asn Gln Lys Arg Ala Glu Pro Asp Arg Ser Arg Arg Gly Trp Asn 
            100                 105                 110         


Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  90
<211>  131
<212>  PRT
<213>  Oryzias latipes

<400>  90

Met Leu Cys Pro Val Leu Leu Cys Ala Thr Leu Leu Leu Leu Thr Pro 
1               5                   10                  15      


Phe Glu Val Thr Glu Ala Arg Ala Leu His Pro Ser Ala Asp Ala Val 
            20                  25                  30          


Gln Phe Val Glu Gln Phe Leu Asp Arg Tyr Asn Asp Leu Leu Thr Leu 
        35                  40                  45              


Asp Asp Leu Glu Asn Leu Leu Asn Thr Gln Pro Glu Glu Gln Ser Thr 
    50                  55                  60                  


Leu Ser Ser Gly Val Lys Thr Ala Glu Tyr Pro Lys Trp Ala Asp Leu 
65                  70                  75                  80  


Gln Thr Gln Pro Glu Thr Pro Trp Phe Arg Leu Leu Lys Gly Ala Leu 
                85                  90                  95      


Thr Asn Gln Lys Arg Ala Glu Pro Asp Arg Ser Arg Arg Gly Trp Asn 
            100                 105                 110         


Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  91
<211>  126
<212>  PRT
<213>  Takifugu rubripes

<400>  91

Met Leu Cys Pro Ala Leu Leu Cys Ala Ala Leu Leu Leu Leu Thr Pro 
1               5                   10                  15      


Val Glu Ile Thr Asp Ala Arg Ala Leu Gln Gln Pro Ser Asp Ala Ala 
            20                  25                  30          


Gln Phe Met Glu Gln Phe Leu Glu Ser Tyr Asn Asp Leu Leu Thr Leu 
        35                  40                  45              


Asp Asp Leu Glu Asn Met Leu Asn Ser His Pro Glu Asp Gln Ser Asn 
    50                  55                  60                  


Leu Ser Ser Ser Lys Ala Asp Glu Tyr Pro Lys Trp Ala Glu Ala Asp 
65                  70                  75                  80  


Thr Pro Trp Leu Arg Leu Leu Arg Gly Ala Leu Ala Asn Gln Lys Arg 
                85                  90                  95      


Ala Glu Pro Asp Arg Ser Arg Arg Gly Trp Asn Arg Gly Cys Phe Gly 
            100                 105                 110         


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        115                 120                 125     


<210>  92
<211>  131
<212>  PRT
<213>  Anguilla japonica

<400>  92

Met Met Cys Lys Ala Leu Val Phe Ala Val Leu Leu Leu Ala Val Pro 
1               5                   10                  15      


Leu Glu Arg Ala Asp Ser Arg Ala Leu Arg Thr Pro Val Asp Ala Ile 
            20                  25                  30          


Gln Phe Val Glu Gln Phe Leu Glu His Tyr Asn Asp Leu Leu Asn Ile 
        35                  40                  45              


Asp Asp Leu Glu Asn Gln Thr Gly Asp Gln Leu Glu Ser Pro Gln Pro 
    50                  55                  60                  


Leu Ser Ser Gly Leu Lys Val Ala Glu Tyr Pro Lys Trp Val Asp Val 
65                  70                  75                  80  


Pro Ser Gln Asn Asp Asn Thr Trp Phe Arg Leu Leu Arg Gly Ala Leu 
                85                  90                  95      


Ala Asn Arg Lys Arg Ala Leu Pro Asp Arg Ala Lys Arg Gly Trp Asn 
            100                 105                 110         


Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        115                 120                 125             


Leu Gly Cys 
    130     


<210>  93
<211>  140
<212>  PRT
<213>  Actinopterygii

<400>  93

Met Met Gly Ser Cys Ser Ala Pro Leu Leu Thr Gly His Arg Ile Leu 
1               5                   10                  15      


Cys Leu Phe Leu Leu Met Ala Ser Ser Leu Ser Pro Ile His Ser Arg 
            20                  25                  30          


Ala Phe Arg Ser Pro Pro Leu Gln Phe Leu Ser Thr Leu Leu Glu Lys 
        35                  40                  45              


Glu Tyr Gly Asn Leu Gln Ser Gly Pro Val Asn Ile His Asn Val Ser 
    50                  55                  60                  


Ser Glu Gln Tyr Glu Asp Pro Gln Pro Trp Ala Asp Val Ser Ser Val 
65                  70                  75                  80  


Ser Lys Glu Gln Ile Trp Gly Asp Glu Pro Pro Ala Asn Glu Asn Ala 
                85                  90                  95      


Leu Tyr Leu Leu Leu Arg Arg Ala Ala Ala Asn Arg Thr Trp Ile Ser 
            100                 105                 110         


Ala Asp Arg Val Lys Lys Ala Trp Ser Lys Gly Cys Phe Gly Leu Lys 
        115                 120                 125             


Leu Asp Arg Ile Gly Ser Ile Ser Gly Leu Gly Cys 
    130                 135                 140 


<210>  94
<211>  123
<212>  PRT
<213>  Gallus gallus

<400>  94

Met Leu Gly Leu Pro Ala Trp Pro Cys Ser Leu Phe Leu Leu Leu Val 
1               5                   10                  15      


Leu Leu Ser Ala Ser Val Gln Ala Met Ser Ser Ser Gly Gln Arg Leu 
            20                  25                  30          


Gln Val Leu Leu Ser Gln Leu Leu Pro Ser Asp Ser Glu Ser Met Pro 
        35                  40                  45              


Ala Glu Glu Asp Met Lys Glu Gly Ser Ser Ser Glu Pro Gln Leu Leu 
    50                  55                  60                  


Ser Pro Pro Leu Pro Leu Leu Pro Ser Arg Ala Arg Ala Ala His Pro 
65                  70                  75                  80  


Leu Leu Trp Arg Lys Ala Leu Ala Ser Arg Lys Arg Ala Leu Ser Gly 
                85                  90                  95      


Asp Trp Ala Trp Lys Ala Val Pro Arg Gly Cys Phe Gly Leu Lys Met 
            100                 105                 110         


Asp Arg Ile Gly Ala Phe Ser Gly Leu Gly Cys 
        115                 120             


<210>  95
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSENSUS SEQUENCE


<220>
<221>  MISC_FEATURE
<222>  (4)..(7)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 31-94

<220>
<221>  MISC_FEATURE
<222>  (10)..(12)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 31-94

<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 31-94

<400>  95

Cys Phe Gly Xaa Xaa Xaa Xaa Arg Ile Xaa Xaa Xaa Ser Gly Xaa Gly 
1               5                   10                  15      


Cys 
    


<210>  96
<211>  28
<212>  PRT
<213>  Rattus norvegicus

<400>  96

Ser Leu Arg Arg Ser Ser Cys Phe Gly Gly Arg Ile Asp Arg Ile Gly 
1               5                   10                  15      


Ala Gln Ser Gly Leu Gly Cys Asn Ser Phe Arg Tyr 
            20                  25              


<210>  97
<211>  45
<212>  PRT
<213>  Rattus norvegicus

<400>  97

Ser Gln Asp Ser Ala Phe Arg Ile Gln Glu Arg Leu Arg Asn Ser Lys 
1               5                   10                  15      


Met Ala His Ser Ser Ser Cys Phe Gly Gln Lys Ile Asp Arg Ile Gly 
            20                  25                  30          


Ala Val Ser Arg Leu Gly Cys Asp Gly Leu Arg Leu Phe 
        35                  40                  45  


<210>  98
<211>  32
<212>  PRT
<213>  Sus scrofa

<400>  98

Ser Pro Lys Thr Met Arg Asp Ser Gly Cys Phe Gly Arg Arg Leu Asp 
1               5                   10                  15      


Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys Asn Val Leu Arg Arg Tyr 
            20                  25                  30          


<210>  99
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (TNP-C)

<400>  99

Ser Asp Ser Lys Ile Gly Asn Gly Cys Phe Gly Phe Pro Leu Asp Arg 
1               5                   10                  15      


Ile Gly Ser Val Ser Gly Leu Gly Cys Asn Arg Ile Met Gln Asn Pro 
            20                  25                  30          


Pro Lys Lys Phe Ser Gly Glu 
        35                  


<210>  100
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP)

<400>  100

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  101
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-N1 (C7))

<400>  101

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Asn Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  102
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-G1 (C8))

<400>  102

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  103
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-H1 (C9))

<400>  103

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys His Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  104
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-K1)

<400>  104

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Lys Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  105
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-Z1)


<220>
<221>  MISC_FEATURE
<222>  (23)..(23)
<223>  Xaa is hydroxyproline

<400>  105

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Xaa Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  106
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-S3)

<400>  106

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  107
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-A4)

<400>  107

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Leu Ala Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  108
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-A5)

<400>  108

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Leu Arg Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  109
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-S3A4 (C12))

<400>  109

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Ala Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  110
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-A4A5)

<400>  110

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Leu Ala Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  111
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-S3A5 (C11))

<400>  111

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Arg Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  112
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-(A17)S3A5)

<400>  112

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ala Ser Gly Leu Gly Cys Pro Ser Ser Arg Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  113
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-S3A4A5 (C10))

<400>  113

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  114
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-(A17)S3A4A5)

<400>  114

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ala Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  115
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-S3A4A5R6 (C13))

<400>  115

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Arg Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  116
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-S3A4A5S7 (C14))

<400>  116

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Pro Ser Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala 
        35          


<210>  117
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (DNP TAIL)

<400>  117

Pro Ser Leu Arg Asp Pro Arg Pro Asn Ala Pro Ser Thr Ser Ala 
1               5                   10                  15  


<210>  118
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSENSUS SEQUENCE FOR DNP C-TERMINAL TAIL


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 100-116

<220>
<221>  MISC_FEATURE
<222>  (3)..(7)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 100-116

<400>  118

Xaa Ser Xaa Xaa Xaa Xaa Xaa Pro Asn Ala Pro Ser Thr Ser Ala 
1               5                   10                  15  


<210>  119
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-F17 (C15))

<400>  119

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Phe Ser Gly Leu Gly Cys 
            20          


<210>  120
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-L17 (C16))

<400>  120

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Leu Ser Gly Leu Gly Cys 
            20          


<210>  121
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-I17 (C17))

<400>  121

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ile Ser Gly Leu Gly Cys 
            20          


<210>  122
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-T17 (C18))

<400>  122

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Thr Ser Gly Leu Gly Cys 
            20          


<210>  123
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-V17 (C19))

<400>  123

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Val Ser Gly Leu Gly Cys 
            20          


<210>  124
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-A17 (C1))

<400>  124

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ala Ser Gly Leu Gly Cys 
            20          


<210>  125
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-S17)

<400>  125

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ser Ser Gly Leu Gly Cys 
            20          


<210>  126
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  CONSENSUS SEQUENCE


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid or any amino acid 
       at the corresponding position in one of SEQ ID NOs: 119-125

<400>  126

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys 
            20          


<210>  127
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37)

<400>  127

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  128
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (E6PGCNP37)

<400>  128

Glu Glu Glu Glu Glu Glu Pro Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  129
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C1(E6))

<400>  129

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  130
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C2(E6))

<400>  130

Glu Glu Glu Glu Glu Glu Ala Ser Thr Ser Pro Ala Asn Pro Gln Pro 
1               5                   10                  15      


Ala Ala Ser Ser Pro Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  131
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C3(E6))

<400>  131

Glu Glu Glu Glu Glu Glu Pro Ser Ser Ala Ala Pro Gln Pro Asn Ala 
1               5                   10                  15      


Pro Ser Thr Ser Ala Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  132
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C4(E6))

<400>  132

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  133
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C5(E6))

<400>  133

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  134
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C6(E6))

<400>  134

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Lys Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  135
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C7(E6))

<400>  135

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  136
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C8(E6))

<400>  136

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  137
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C9(E6))

<400>  137

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  138
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C10(E6))

<400>  138

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  139
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C11(E6))

<400>  139

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Lys Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  140
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D6CNP37)

<400>  140

Asp Asp Asp Asp Asp Asp Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  141
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C1(D6))

<400>  141

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  142
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C2(D6))

<400>  142

Asp Asp Asp Asp Asp Asp Ala Ser Thr Ser Pro Ala Asn Pro Gln Pro 
1               5                   10                  15      


Ala Ala Ser Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  143
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C3(D6))

<400>  143

Asp Asp Asp Asp Asp Asp Gly Ser Ser Ala Ala Pro Gln Pro Asn Ala 
1               5                   10                  15      


Pro Ser Thr Ser Ala Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  144
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C4(D6))

<400>  144

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  145
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C5(D6))

<400>  145

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  146
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C6(D6))

<400>  146

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  147
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D6-14AAlinker-CNP)

<400>  147

Asp Asp Asp Asp Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40          


<210>  148
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-14AAlinker-D6)

<400>  148

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Asp Asp Asp Asp Asp Asp 
        35                  40          


<210>  149
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-Nterm1)

<400>  149

Gly Ser Ser Ala Ala Pro Arg Pro Asn Ala Pro Ser Thr Ser Ala Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  150
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-Nterm2)

<400>  150

Ala Ser Thr Ser Pro Ala Asn Pro Arg Pro Ala Ala Ser Ser Gly Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  151
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP29-S3A4A5R6 [C14])

<400>  151

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Arg Arg 
            20                  25                  


<210>  152
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA1)

<400>  152

His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40          


<210>  153
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA1(E6))

<400>  153

Glu Glu Glu Glu Glu Glu His Gly Pro Gln Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  154
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB1)

<400>  154

His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40          


<210>  155
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB1(E6))

<400>  155

Glu Glu Glu Glu Glu Glu His Lys Leu Arg Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  156
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-E17)

<400>  156

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Glu Ser Gly Leu Gly Cys 
            20          


<210>  157
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-R17)

<400>  157

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Arg Ser Gly Leu Gly Cys 
            20          


<210>  158
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-Y17)

<400>  158

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Tyr Ser Gly Leu Gly Cys 
            20          


<210>  159
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-C17)

<400>  159

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Cys Ser Gly Leu Gly Cys 
            20          


<210>  160
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-P17)

<400>  160

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Pro Ser Gly Leu Gly Cys 
            20          


<210>  161
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-D17)

<400>  161

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Asp Ser Gly Leu Gly Cys 
            20          


<210>  162
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-X17)


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  162

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  163
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-F17)

<400>  163

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  164
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-L17)

<400>  164

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  165
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-I17)

<400>  165

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Ile 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  166
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-T17)

<400>  166

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Thr 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  167
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-E17)

<400>  167

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Glu 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  168
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-R17)

<400>  168

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  169
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-Y17)

<400>  169

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  170
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-C17)

<400>  170

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Cys 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  171
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-P17)

<400>  171

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Pro 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  172
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP37-D17)

<400>  172

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Asp 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  173
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA1-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  173

His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  174
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA2-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  174

Ser Gly Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  175
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA3-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  175

Gly Gly Gly His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  176
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA4-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  176

Gly Gly Gly Ser Gly Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  177
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA5-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  177

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  178
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA6-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  178

His Gly Pro Gln Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  179
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA7-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  179

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  180
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA8-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  180

Gly Gly Gly His Gly Pro Gln Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  181
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB1-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  181

His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  182
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB2-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  182

Gly Gly Gly His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  183
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB3-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  183

His Lys Leu Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  184
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB4-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  184

Gly Gly Gly His Lys Leu Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  185
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (PGCNP37-X17)


<220>
<221>  MISC_FEATURE
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  185

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Xaa Ser Gly Leu Gly Cys 
        35                  


<210>  186
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA1(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  186

Glu Glu Glu Glu Glu Glu His Gly Pro Gln Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  187
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA2(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  187

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  188
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA3(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  188

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Gly Pro Gln Gly Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  189
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA4(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  189

Glu Glu Glu Glu Glu Glu Gly Gly Gly Ser Gly Gly Gly Gly Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  190
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA5(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  190

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  191
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA6(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  191

Glu Glu Glu Glu Glu Glu His Gly Pro Gln Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  192
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA7(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  192

Glu Glu Glu Glu Glu Glu Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  193
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construst (KA8(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  193

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Gly Pro Gln Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  194
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB1(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  194

Glu Glu Glu Glu Glu Glu His Lys Leu Arg Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  195
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB2(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  XXaa can be any naturally occurring amino acid, including but not
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  195

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Lys Leu Arg Gly Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  196
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB3(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  196

Glu Glu Glu Glu Glu Glu His Lys Leu Arg Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  197
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB4(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  197

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Lys Leu Arg Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  198
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (E6PGCNP37-X17)


<220>
<221>  MISC_FEATURE
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  198

Glu Glu Glu Glu Glu Glu Pro Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  199
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C1(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  199

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  200
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C2(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  200

Glu Glu Glu Glu Glu Glu Ala Ser Thr Ser Pro Ala Asn Pro Gln Pro 
1               5                   10                  15      


Ala Ala Ser Ser Pro Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  201
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C3(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  201

Glu Glu Glu Glu Glu Glu Pro Ser Ser Ala Ala Pro Gln Pro Asn Ala 
1               5                   10                  15      


Pro Ser Thr Ser Ala Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  202
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C4(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  202

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  203
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C5(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  203

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  204
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C6(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  204

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Lys Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  205
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C7(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  205

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  206
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C8(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  206

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  207
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C9(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  207

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  208
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C10(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  208

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  209
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C11(E6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  209

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Lys Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  210
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D6CNP37-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  210

Asp Asp Asp Asp Asp Asp Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  211
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C1(D6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  211

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  212
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C2(D6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  212

Asp Asp Asp Asp Asp Asp Ala Ser Thr Ser Pro Ala Asn Pro Gln Pro 
1               5                   10                  15      


Ala Ala Ser Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  213
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C3(D6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  213

Asp Asp Asp Asp Asp Asp Gly Ser Ser Ala Ala Pro Gln Pro Asn Ala 
1               5                   10                  15      


Pro Ser Thr Ser Ala Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  214
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C4(D6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  214

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  215
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C5(D6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  215

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln 
1               5                   10                  15      


Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  216
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (C6(D6)-X17)


<220>
<221>  MISC_FEATURE
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  216

Asp Asp Asp Asp Asp Asp Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys 
1               5                   10                  15      


Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40              


<210>  217
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D6-14AAlinker-CNP-X17)


<220>
<221>  MISC_FEATURE
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  217

Asp Asp Asp Asp Asp Asp Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        35                  40          


<210>  218
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-14AAlinker-D6-X17)


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  218

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Asp Asp Asp Asp Asp Asp 
        35                  40          


<210>  219
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-Nterm1-X17)


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  219

Gly Ser Ser Ala Ala Pro Arg Pro Asn Ala Pro Ser Thr Ser Ala Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  220
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-Nterm2-X17)


<220>
<221>  MISC_FEATURE
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  220

Ala Ser Thr Ser Pro Ala Asn Pro Arg Pro Ala Ala Ser Ser Gly Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  221
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA1(E6)-L17)

<400>  221

Glu Glu Glu Glu Glu Glu His Gly Pro Gln Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  222
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA2(E6)-L17)

<400>  222

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  223
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA3(E6)-L17)

<400>  223

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Gly Pro Gln Gly Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  224
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA4(E6)-L17)

<400>  224

Glu Glu Glu Glu Glu Glu Gly Gly Gly Ser Gly Gly Gly Gly Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  225
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA5(E6)-L17)

<400>  225

Glu Glu Glu Glu Glu Glu Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  226
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA6(E6)-L17)

<400>  226

Glu Glu Glu Glu Glu Glu His Gly Pro Gln Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  227
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA7(E6)-L17)

<400>  227

Glu Glu Glu Glu Glu Glu Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  228
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KA8(E6)-L17)

<400>  228

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Gly Pro Gln Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  229
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB1(E6)-L17)

<400>  229

Glu Glu Glu Glu Glu Glu His Lys Leu Arg Gly Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  230
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB2(E6)-L17)

<400>  230

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Lys Leu Arg Gly Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  231
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB3(E6)-L17)

<400>  231

Glu Glu Glu Glu Glu Glu His Lys Leu Arg Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  232
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (KB4(E6)-L17)

<400>  232

Glu Glu Glu Glu Glu Glu Gly Gly Gly His Lys Leu Arg Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  233
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (E6PGCNP37-L17)

<400>  233

Glu Glu Glu Glu Glu Glu Pro Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  234

<400>  234
000

<210>  235

<400>  235
000

<210>  236

<400>  236
000

<210>  237

<400>  237
000

<210>  238

<400>  238
000

<210>  239

<400>  239
000

<210>  240

<400>  240
000

<210>  241

<400>  241
000

<210>  242

<400>  242
000

<210>  243

<400>  243
000

<210>  244

<400>  244
000

<210>  245

<400>  245
000

<210>  246

<400>  246
000

<210>  247

<400>  247
000

<210>  248

<400>  248
000

<210>  249

<400>  249
000

<210>  250

<400>  250
000

<210>  251

<400>  251
000

<210>  252

<400>  252
000

<210>  253

<400>  253
000

<210>  254

<400>  254
000

<210>  255

<400>  255
000

<210>  256

<400>  256
000

<210>  257

<400>  257
000

<210>  258

<400>  258
000

<210>  259

<400>  259
000

<210>  260

<400>  260
000

<210>  261

<400>  261
000

<210>  262

<400>  262
000

<210>  263

<400>  263
000

<210>  264

<400>  264
000

<210>  265

<400>  265
000

<210>  266

<400>  266
000

<210>  267

<400>  267
000

<210>  268

<400>  268
000

<210>  269

<400>  269
000

<210>  270

<400>  270
000

<210>  271

<400>  271
000

<210>  272

<400>  272
000

<210>  273

<400>  273
000

<210>  274

<400>  274
000

<210>  275

<400>  275
000

<210>  276

<400>  276
000

<210>  277

<400>  277
000

<210>  278

<400>  278
000

<210>  279

<400>  279
000

<210>  280

<400>  280
000

<210>  281

<400>  281
000

<210>  282

<400>  282
000

<210>  283

<400>  283
000

<210>  284

<400>  284
000

<210>  285

<400>  285
000

<210>  286

<400>  286
000

<210>  287

<400>  287
000

<210>  288

<400>  288
000

<210>  289

<400>  289
000

<210>  290

<400>  290
000

<210>  291

<400>  291
000

<210>  292

<400>  292
000

<210>  293

<400>  293
000

<210>  294

<400>  294
000

<210>  295

<400>  295
000

<210>  296

<400>  296
000

<210>  297

<400>  297
000

<210>  298

<400>  298
000

<210>  299

<400>  299
000

<210>  300

<400>  300
000

<210>  301
<211>  1
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  301

Gly 
1   


<210>  302
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  302

Gly Gly 
1       


<210>  303
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  303

Gly Gly Gly 
1           


<210>  304
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  304

Gly Gly Gly Gly 
1               


<210>  305
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  305

Gly Gly Gly Gly Ser 
1               5   


<210>  306
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  306

Gly Gly Gly Gly Ser Gly 
1               5       


<210>  307
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  307

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  


<210>  308
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  308

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


<210>  309
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  309

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly 
            20          


<210>  310
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  310

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
            20                  25              


<210>  311
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  311

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly 
        


<210>  312
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  312

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40  


<210>  313
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  313

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
            20                  25                  30          


Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        35                  40                  45      


<210>  314
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  314

Lys Gly Ala Asn Lys Lys 
1               5       


<210>  315
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  315

Lys Gly Ala Asn Gln Lys 
1               5       


<210>  316
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  316

Lys Gly Ala Asn Lys Gln 
1               5       


<210>  317
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  317

Lys Gly Ala Asn Gln Gln 
1               5       


<210>  318
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  318

Gln Gly Ala Asn Lys Lys 
1               5       


<210>  319
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  319

Gln Gly Ala Asn Gln Lys 
1               5       


<210>  320
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  320

Gln Gly Ala Asn Lys Gln 
1               5       


<210>  321
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  321

Gln Gly Ala Asn Gln Gln 
1               5       


<210>  322
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  322

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


<210>  323
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  323

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys 
1               5                   10                  15      


<210>  324
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  324

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Gln 
1               5                   10                  15      


<210>  325
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  325

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Gln 
1               5                   10                  15      


<210>  326
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  326

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Ala Asn Lys Lys 
1               5                   10                  15      


<210>  327
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  327

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Ala Asn Gln Lys 
1               5                   10                  15      


<210>  328
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  328

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Ala Asn Lys Gln 
1               5                   10                  15      


<210>  329
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  329

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Gly Ala Asn Gln Gln 
1               5                   10                  15      


<210>  330
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  330

Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala 
1               5                   10                  15      


Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn 
            20                  25                  30          


Lys Lys 
        


<210>  331
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  331

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn 
            20                  25                  30          


Lys Lys 
        


<210>  332
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  332

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn 
            20                  25                  30          


Gln Lys 
        


<210>  333
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  333

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Gly Ala Asn 
            20                  25                  30          


Gln Gln 
        


<210>  334
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  334

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15  


<210>  335
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  335

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


<210>  336
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  336

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys 
    


<210>  337
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  337

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15  


<210>  338
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  338

Ala Ser Thr Ser Pro Ala Asn Pro Gln Pro Ala Ala Ser Ser Pro 
1               5                   10                  15  


<210>  339
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  339

Pro Ser Ser Ala Ala Pro Gln Pro Asn Ala Pro Ser Thr Ser Ala 
1               5                   10                  15  


<210>  340
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  340

Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys 
1               5                   10                  15  


<210>  341
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  341

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Gly Ala Asn Gln Gln 
1               5                   10                  15  


<210>  342
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  342

Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Gln 
1               5                   10                  15  


<210>  343
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  343

Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Gln Lys 
1               5                   10                  15  


<210>  344
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  344

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Gly Ala Asn Lys Lys 
1               5                   10                  15  


<210>  345
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  345

Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Gln Gln 
1               5                   10                  15  


<210>  346
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  346

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Gly Ala Asn Gln Lys 
1               5                   10                  15  


<210>  347
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  347

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gln Gly Ala Asn Lys Gln 
1               5                   10                  15  


<210>  348
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  348

Ala Ser Thr Ser Pro Ala Asn Pro Gln Pro Ala Ala Ser Ser Gly 
1               5                   10                  15  


<210>  349
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  349

Gly Ser Ser Ala Ala Pro Gln Pro Asn Ala Pro Ser Thr Ser Ala 
1               5                   10                  15  


<210>  350
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  350

Gly Ser Ser Ala Ala Pro Arg Pro Asn Ala Pro Ser Thr Ser Ala Gly 
1               5                   10                  15      


Leu Ser Lys Gly 
            20  


<210>  351
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  351

Ala Ser Thr Ser Pro Ala Asn Pro Arg Pro Ala Ala Ser Ser Gly 
1               5                   10                  15  


<210>  352
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  352

His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  353
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  353

His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  354
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  354

Gly His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys 
            20      


<210>  355
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  355

Gly His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys 
            20      


<210>  356
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  356

Gly Gly His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys Tyr 
1               5                   10                  15      


Lys Gly Ala Asn Lys Lys 
            20          


<210>  357
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  357

Gly Gly His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys Tyr 
1               5                   10                  15      


Lys Gly Ala Asn Lys Lys 
            20          


<210>  358
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  358

Gly Gly Gly His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys 
            20              


<210>  359
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  359

Gly Gly Gly His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys 
            20              


<210>  360
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  360

Gly Gly Gly Gly His Gly Pro Gln Gly Gln Glu His Pro Asn Ala Arg 
1               5                   10                  15      


Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  


<210>  361
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  361

Gly Gly Gly Gly His Lys Leu Arg Gly Gln Glu His Pro Asn Ala Arg 
1               5                   10                  15      


Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  


<210>  362
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  362

Gly Gly Gly Gly Gly His Gly Pro Gln Gly Gln Glu His Pro Asn Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25  


<210>  363
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  363

Gly Gly Gly Gly Gly His Lys Leu Arg Gly Gln Glu His Pro Asn Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25  


<210>  364
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  364

His Gly Pro Gln Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  365
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  365

His Lys Leu Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  366
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  366

Gly Gly Gly His Gly Pro Gln Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Lys Gly Ala Asn Lys Lys 
            20              


<210>  367
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  367

Gly Gly Gly His Lys Leu Arg Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Lys Gly Ala Asn Lys Lys 
            20              


<210>  368
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  368

Ser Gly Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  369
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  369

Gly Gly Gly Ser Gly Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys 
            20              


<210>  370
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  370

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  371
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  371

Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Gly Lys Gly Ala Asn Lys Lys 
            20                  25  


<210>  372
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  372

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Lys Gly Ala Asn Lys Lys 
            20              


<210>  373
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  373

Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
1               5                   10                  15      


Gly Gly Ser Gly Gly Gly Lys Gly Ala Asn Lys Lys 
            20                  25              


<210>  374
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  374

His Gly Pro Gln Gly 
1               5   


<210>  375
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  375

His Lys Leu Arg Gly 
1               5   


<210>  376
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  376

Gly His Gly Pro Gln Gly 
1               5       


<210>  377
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  377

Gly Gly His Gly Pro Gln Gly 
1               5           


<210>  378
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  378

Gly Gly Gly His Gly Pro Gln Gly 
1               5               


<210>  379
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  379

Gly Gly Gly Gly His Gly Pro Gln Gly 
1               5                   


<210>  380
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  380

Gly Gly Gly Gly Gly His Gly Pro Gln Gly 
1               5                   10  


<210>  381
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  381

Gly His Lys Leu Arg Gly 
1               5       


<210>  382
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  382

Gly Gly His Lys Leu Arg Gly 
1               5           


<210>  383
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  383

Gly Gly Gly His Lys Leu Arg Gly 
1               5               


<210>  384
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  384

Gly Gly Gly Gly His Lys Leu Arg Gly 
1               5                   


<210>  385
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  385

Gly Gly Gly Gly Gly His Lys Leu Arg Gly 
1               5                   10  


<210>  386
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  386

Gly Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys 
    


<210>  387
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  387

Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn 
1               5                   10                  15      


Lys Lys 
        


<210>  388
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  388

Gly Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala 
1               5                   10                  15      


Asn Lys Lys 
            


<210>  389
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  389

Gly Gly Gly Gly Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys 
            20  


<210>  390
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  390

Leu Lys 
1       


<210>  391
<211>  2
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  391

Asp Ile 
1       


<210>  392

<400>  392
000

<210>  393

<400>  393
000

<210>  394

<400>  394
000

<210>  395

<400>  395
000

<210>  396

<400>  396
000

<210>  397

<400>  397
000

<210>  398

<400>  398
000

<210>  399

<400>  399
000

<210>  400

<400>  400
000

<210>  401
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Exemplary Fc Sequence (IgG-1))

<400>  401

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  402

<400>  402
000

<210>  403

<400>  403
000

<210>  404

<400>  404
000

<210>  405

<400>  405
000

<210>  406

<400>  406
000

<210>  407

<400>  407
000

<210>  408

<400>  408
000

<210>  409

<400>  409
000

<210>  410

<400>  410
000

<210>  411

<400>  411
000

<210>  412

<400>  412
000

<210>  413

<400>  413
000

<210>  414

<400>  414
000

<210>  415

<400>  415
000

<210>  416

<400>  416
000

<210>  417

<400>  417
000

<210>  418

<400>  418
000

<210>  419

<400>  419
000

<210>  420

<400>  420
000

<210>  421

<400>  421
000

<210>  422

<400>  422
000

<210>  423

<400>  423
000

<210>  424

<400>  424
000

<210>  425

<400>  425
000

<210>  426

<400>  426
000

<210>  427

<400>  427
000

<210>  428

<400>  428
000

<210>  429

<400>  429
000

<210>  430

<400>  430
000

<210>  431

<400>  431
000

<210>  432

<400>  432
000

<210>  433

<400>  433
000

<210>  434

<400>  434
000

<210>  435

<400>  435
000

<210>  436

<400>  436
000

<210>  437

<400>  437
000

<210>  438

<400>  438
000

<210>  439

<400>  439
000

<210>  440

<400>  440
000

<210>  441

<400>  441
000

<210>  442

<400>  442
000

<210>  443

<400>  443
000

<210>  444

<400>  444
000

<210>  445

<400>  445
000

<210>  446

<400>  446
000

<210>  447

<400>  447
000

<210>  448

<400>  448
000

<210>  449

<400>  449
000

<210>  450

<400>  450
000

<210>  451

<400>  451
000

<210>  452

<400>  452
000

<210>  453

<400>  453
000

<210>  454

<400>  454
000

<210>  455

<400>  455
000

<210>  456

<400>  456
000

<210>  457

<400>  457
000

<210>  458

<400>  458
000

<210>  459

<400>  459
000

<210>  460

<400>  460
000

<210>  461

<400>  461
000

<210>  462

<400>  462
000

<210>  463

<400>  463
000

<210>  464

<400>  464
000

<210>  465

<400>  465
000

<210>  466

<400>  466
000

<210>  467

<400>  467
000

<210>  468

<400>  468
000

<210>  469

<400>  469
000

<210>  470

<400>  470
000

<210>  471

<400>  471
000

<210>  472

<400>  472
000

<210>  473

<400>  473
000

<210>  474

<400>  474
000

<210>  475

<400>  475
000

<210>  476

<400>  476
000

<210>  477

<400>  477
000

<210>  478

<400>  478
000

<210>  479

<400>  479
000

<210>  480

<400>  480
000

<210>  481

<400>  481
000

<210>  482

<400>  482
000

<210>  483

<400>  483
000

<210>  484

<400>  484
000

<210>  485

<400>  485
000

<210>  486

<400>  486
000

<210>  487

<400>  487
000

<210>  488

<400>  488
000

<210>  489

<400>  489
000

<210>  490

<400>  490
000

<210>  491

<400>  491
000

<210>  492

<400>  492
000

<210>  493

<400>  493
000

<210>  494

<400>  494
000

<210>  495

<400>  495
000

<210>  496

<400>  496
000

<210>  497

<400>  497
000

<210>  498

<400>  498
000

<210>  499

<400>  499
000

<210>  500

<400>  500
000

<210>  501
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2st Protein Sequence (With Signal 
       Sequence))

<400>  501

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Ala Ser Trp Ser His Pro Gln 
            20                  25                  30          


Phe Glu Gln Ser Gly Gly Gly Gly Gly Glu Asn Leu Tyr Phe Gln Gly 
        35                  40                  45              


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
    290                 295                 300                 


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
305                 310                 


<210>  502
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2st Protein Sequence (Without Signal 
       Sequence))

<400>  502

Ala Ser Trp Ser His Pro Gln Phe Glu Gln Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Gly Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
145                 150                 155                 160 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Ser Lys Gly 
            260                 265                 270         


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
        275                 280                 285             


Cys 
    


<210>  503
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B (w/ sig. seq.))

<400>  503

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  504
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct  (NC2B (w/o sig. seq.))

<400>  504

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Met Ser Gly Leu Gly Cys 
            260                 265 


<210>  505
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct  (NC2B-22  (w/ sig. seq.))

<400>  505

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
        275                 280                 285             


Gly Ser Met Ser Gly Leu Gly Cys 
    290                 295     


<210>  506
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-22 (w/o sig. seq.))

<400>  506

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Leu Ser Lys Gly Cys Phe 
                245                 250                 255     


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            260                 265                 270     


<210>  507
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-28  (w/ sig. seq.))

<400>  507

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly 
        275                 280                 285             


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
    290                 295                 300         


<210>  508
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-28 (w/o sig. seq.))

<400>  508

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            260                 265                 270         


Ser Gly Leu Gly Cys 
        275         


<210>  509
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-34  (w/ sig. seq.))

<400>  509

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  510
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-34 (w/o sig. seq.))

<400>  510

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        275                 280             


<210>  511
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK (w/ sig. seq.))

<400>  511

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  512
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK (w/o sig. seq.))

<400>  512

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Met Ser Gly Leu Gly Cys 
            260                 265 


<210>  513
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK (w/ sig. seq.))

<400>  513

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  514
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK (w/o sig. seq.))

<400>  514

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Met Ser Gly Leu Gly Cys 
            260                 265 


<210>  515
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2 (w/ sig. seq.))

<400>  515

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  516
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2 (w/o sig. seq.))

<400>  516

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala 
225                 230                 235                 240 


Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        275                 280             


<210>  517
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-A (w/ sig. seq.))

<400>  517

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Ala Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  518
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-A (w/o sig. seq.))

<400>  518

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala 
225                 230                 235                 240 


Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Ala Ser Gly Leu Gly Cys 
        275                 280             


<210>  519
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-AAA (w/ sig. seq.)

<400>  519

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Ala Ala Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Ala Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  520
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-AAA (w/o sig. seq.))

<400>  520

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala 
225                 230                 235                 240 


Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
                245                 250                 255     


Gly Ala Asn Ala Ala Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Ala Ser Gly Leu Gly Cys 
        275                 280             


<210>  521
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-16AAlinker-Fc-His10 (NC1))

<400>  521

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Glu Asn Leu Tyr Phe 
            260                 265                 270         


Gln Gly Ser His His His His His His His His His His 
        275                 280                 285 


<210>  522
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-6AAlinker-Fc-His10 (NC3))

<400>  522

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Gly Glu Asn Leu Tyr Phe Gln Gly Ser His His His His His His His 
            260                 265                 270         


His His His 
        275 


<210>  523
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-6AAlinker-Fc)

<400>  523

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 255 


<210>  524
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-Fc)

<400>  524

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    130                 135                 140                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 


<210>  525
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-A17saa-Fc)

<400>  525

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ala Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    130                 135                 140                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 


<210>  526
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-A17sra-Fc)

<400>  526

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Ala Ser Gly Leu Gly Cys Pro Ser Ser Arg Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    130                 135                 140                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 


<210>  527
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2st-X17 (w/ sig. seq.)


<220>
<221>  MISC_FEATURE
<222>  (309)..(309)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  527

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Ala Ser Trp Ser His Pro Gln 
            20                  25                  30          


Phe Glu Gln Ser Gly Gly Gly Gly Gly Glu Asn Leu Tyr Phe Gln Gly 
        35                  40                  45              


Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
    50                  55                  60                  


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
65                  70                  75                  80  


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
                85                  90                  95      


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
            100                 105                 110         


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
        115                 120                 125             


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
    130                 135                 140                 


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
145                 150                 155                 160 


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
                165                 170                 175     


Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 
            180                 185                 190         


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
        195                 200                 205             


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
    210                 215                 220                 


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
225                 230                 235                 240 


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
                245                 250                 255     


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
            260                 265                 270         


Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
        275                 280                 285             


Gly Gly Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
    290                 295                 300                 


Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
305                 310                 


<210>  528
<211>  289
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2st-X17  (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (284)..(284)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  528

Ala Ser Trp Ser His Pro Gln Phe Glu Gln Ser Gly Gly Gly Gly Gly 
1               5                   10                  15      


Glu Asn Leu Tyr Phe Gln Gly Gly Asp Lys Thr His Thr Cys Pro Pro 
            20                  25                  30          


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        35                  40                  45              


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    50                  55                  60                  


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
65                  70                  75                  80  


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                85                  90                  95      


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            100                 105                 110         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        115                 120                 125             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    130                 135                 140                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
145                 150                 155                 160 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                165                 170                 175     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            180                 185                 190         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        195                 200                 205             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    210                 215                 220                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
225                 230                 235                 240 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser 
                245                 250                 255     


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Ser Lys Gly 
            260                 265                 270         


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly 
        275                 280                 285             


Cys 
    


<210>  529
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-X17 w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  529

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  530
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  530

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
            260                 265 


<210>  531
<211>  296
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-22-X17  (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  531

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
        275                 280                 285             


Gly Ser Xaa Ser Gly Leu Gly Cys 
    290                 295     


<210>  532
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-22-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (266)..(266)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  532

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Leu Ser Lys Gly Cys Phe 
                245                 250                 255     


Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
            260                 265                 270     


<210>  533
<211>  302
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-28-X17 (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  533

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly 
        275                 280                 285             


Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
    290                 295                 300         


<210>  534
<211>  277
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-28-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (272)..(272)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  534

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa 
            260                 265                 270         


Ser Gly Leu Gly Cys 
        275         


<210>  535
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-34-X17 (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (303)..(303)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  535

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  536
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2B-34-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid

<400>  536

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        275                 280             


<210>  537
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-X17 (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  537

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  538
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  538

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
            260                 265 


<210>  539
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-X17 (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (285)..(285)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  539

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  540
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (260)..(260)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  540

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
            260                 265 


<210>  541
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-X17 (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (303)..(303)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  541

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  542
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  542

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala 
225                 230                 235                 240 


Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        275                 280             


<210>  543
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-X17 (w/ sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (303)..(303)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  543

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  544
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  544

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala 
225                 230                 235                 240 


Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        275                 280             


<210>  545
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-AA-X17 (w/sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (303)..(303)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  545

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Ala Ala Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Xaa Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  546
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Fc-CNP53-AA-X17 (w/o sig. seq.))


<220>
<221>  MISC_FEATURE
<222>  (278)..(278)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  546

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala 
225                 230                 235                 240 


Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
                245                 250                 255     


Gly Ala Asn Ala Ala Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Xaa Ser Gly Leu Gly Cys 
        275                 280             


<210>  547
<211>  285
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-X17-16AAlinker-Fc-His10 (NC1))


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  547

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
        35                  40                  45              


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
    50                  55                  60                  


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
65                  70                  75                  80  


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
                85                  90                  95      


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
            100                 105                 110         


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
        115                 120                 125             


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
    130                 135                 140                 


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
145                 150                 155                 160 


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 
                165                 170                 175     


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
            180                 185                 190         


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
        195                 200                 205             


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
    210                 215                 220                 


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
225                 230                 235                 240 


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
                245                 250                 255     


Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Glu Asn Leu Tyr Phe 
            260                 265                 270         


Gln Gly Ser His His His His His His His His His His 
        275                 280                 285 


<210>  548
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-X17-6AAlinker-Fc-His10 (NC3))


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  548

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly 
                245                 250                 255     


Gly Glu Asn Leu Tyr Phe Gln Gly Ser His His His His His His His 
            260                 265                 270         


His His His 
        275 


<210>  549
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CNP-X17-6AAlinker-Fc)


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  549

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Gly Gly Gly Gly Ser Gly Asp Lys Thr His 
            20                  25                  30          


Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
        35                  40                  45              


Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
    50                  55                  60                  


Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
65                  70                  75                  80  


Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
                85                  90                  95      


Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
            100                 105                 110         


Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
        115                 120                 125             


Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
    130                 135                 140                 


Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
145                 150                 155                 160 


Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
                165                 170                 175     


Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
            180                 185                 190         


Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
        195                 200                 205             


Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
    210                 215                 220                 


Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
225                 230                 235                 240 


His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                245                 250                 255 


<210>  550
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-X17-Fc)


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  550

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Pro Ser Leu Arg Asp Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    130                 135                 140                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 


<210>  551
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-X17-saa-Fc)


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  551

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Pro Ser Ser Ala Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    130                 135                 140                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 


<210>  552
<211>  264
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (CDNP-X17-sra-Fc)


<220>
<221>  MISC_FEATURE
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid, including but not 
       limited to Phe, Leu, Ile, Thr, Glu, Arg, Tyr, Cys, Pro, or Asp

<400>  552

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Xaa Ser Gly Leu Gly Cys Pro Ser Ser Arg Ala Pro Arg Pro Asn Ala 
            20                  25                  30          


Pro Ser Thr Ser Ala Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
        35                  40                  45              


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
    50                  55                  60                  


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
65                  70                  75                  80  


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
                85                  90                  95      


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
            100                 105                 110         


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
        115                 120                 125             


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
    130                 135                 140                 


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
145                 150                 155                 160 


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr 
                165                 170                 175     


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
            180                 185                 190         


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
        195                 200                 205             


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
    210                 215                 220                 


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
225                 230                 235                 240 


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
                245                 250                 255     


Ser Leu Ser Leu Ser Pro Gly Lys 
            260                 


<210>  553
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK (w/sig. seq.))

<400>  553

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  554
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK (w/o sig. seq.))

<400>  554

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  555
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK (w/sig. seq.))

<400>  555

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  556
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK (w/o sig. seq.))

<400>  556

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  557
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2 (w/sig. seq.))

<400>  557

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln 
            260                 265                 270         


Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln 
        275                 280                 285             


Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
    290                 295                 300                 


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
305                 310                 315             


<210>  558
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2 (w/o sig. seq.))

<400>  558

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu 
                245                 250                 255     


Gln Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly 
            260                 265                 270         


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
        275                 280                 285             


Ser Gly Leu Gly Cys 
    290             


<210>  559
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-F17 (w/sig. seq.))

<400>  559

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  560
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-F17 (w/o sig. seq.))

<400>  560

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Phe Ser Gly Leu Gly Cys 
            260                 265 


<210>  561
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-F17 (w/sig. seq.))

<400>  561

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  562
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-F17 (w/o sig. seq.))

<400>  562

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Phe Ser Gly Leu Gly Cys 
            260                 265 


<210>  563
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-F17 (w/sig. seq.))

<400>  563

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  564
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-F17 (w/o sig. seq.))

<400>  564

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala 
225                 230                 235                 240 


Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
        275                 280             


<210>  565
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-F17 (w/sig. seq.))

<400>  565

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  566
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-F17 (w/o sig. seq.))

<400>  566

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  567
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-F17 (w/sig. seq.))

<400>  567

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  568
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-F17 (w/o sig. seq.))

<400>  568

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  569
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-F17 (w/sig. seq.))

<400>  569

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln 
            260                 265                 270         


Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln 
        275                 280                 285             


Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
    290                 295                 300                 


Leu Lys Leu Asp Arg Ile Gly Ser Phe Ser Gly Leu Gly Cys 
305                 310                 315             


<210>  570
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-F17 (w/o sig. seq.))

<400>  570

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu 
                245                 250                 255     


Gln Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly 
            260                 265                 270         


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Phe 
        275                 280                 285             


Ser Gly Leu Gly Cys 
    290             


<210>  571
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-L17 (w/sig. seq.))

<400>  571

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  572
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-L17 (w/o sig. seq.))

<400>  572

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Leu Ser Gly Leu Gly Cys 
            260                 265 


<210>  573
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-L17 (w/sig. seq.))

<400>  573

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  574
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-L17 (w/o sig. seq.))

<400>  574

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Leu Ser Gly Leu Gly Cys 
            260                 265 


<210>  575
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-L17 (w/sig. seq.))

<400>  575

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  576
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-L17 (w/o sig. seq.))

<400>  576

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala 
225                 230                 235                 240 


Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
        275                 280             


<210>  577
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-L17 (w/sig. seq.))

<400>  577

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  578
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-L17 (w/o sig. seq.))

<400>  578

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  579
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-L17 (w/sig. seq.))

<400>  579

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  580
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-L17 (w/o sig. seq.))

<400>  580

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  581
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-L17 (w/sig. seq.))

<400>  581

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln 
            260                 265                 270         


Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln 
        275                 280                 285             


Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
    290                 295                 300                 


Leu Lys Leu Asp Arg Ile Gly Ser Leu Ser Gly Leu Gly Cys 
305                 310                 315             


<210>  582
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-L17 (w/o sig. seq.))

<400>  582

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu 
                245                 250                 255     


Gln Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly 
            260                 265                 270         


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Leu 
        275                 280                 285             


Ser Gly Leu Gly Cys 
    290             


<210>  583
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-R17 (w/sig. seq.))

<400>  583

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  584
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-R17 (w/o sig. seq.))

<400>  584

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Arg Ser Gly Leu Gly Cys 
            260                 265 


<210>  585
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-R17 (w/sig. seq.))

<400>  585

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  586
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-R17 (w/o sig. seq.))

<400>  586

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Arg Ser Gly Leu Gly Cys 
            260                 265 


<210>  587
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-R17 (w/sig. seq.))

<400>  587

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  588
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-R17 (w/o sig. seq.))

<400>  588

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala 
225                 230                 235                 240 


Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Arg Ser Gly Leu Gly Cys 
        275                 280             


<210>  589
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-R17 (w/sig. seq.))

<400>  589

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Arg Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  590
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-R17 (w/o sig. seq.))

<400>  590

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  591
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-R17 (w/sig. seq.))

<400>  591

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Arg Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  592
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-R17 (w/o sig. seq.))

<400>  592

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  593
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-R17 (w/sig. seq.))

<400>  593

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln 
            260                 265                 270         


Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln 
        275                 280                 285             


Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
    290                 295                 300                 


Leu Lys Leu Asp Arg Ile Gly Ser Arg Ser Gly Leu Gly Cys 
305                 310                 315             


<210>  594
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-R17 (w/o sig. seq.))

<400>  594

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu 
                245                 250                 255     


Gln Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly 
            260                 265                 270         


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Arg 
        275                 280                 285             


Ser Gly Leu Gly Cys 
    290             


<210>  595
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-Y17 (w/sig. seq.))

<400>  595

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  596
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANKK-Y17 (w/o sig. seq.))

<400>  596

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Tyr Ser Gly Leu Gly Cys 
            260                 265 


<210>  597
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-Y17 (w/sig. seq.))

<400>  597

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly 
                245                 250                 255     


Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys 
            260                 265                 270         


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr Ser Gly Leu 
        275                 280                 285             


Gly Cys 
    290 


<210>  598
<211>  265
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-KGANQK-Y17 (w/o sig. seq.))

<400>  598

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala 
225                 230                 235                 240 


Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
                245                 250                 255     


Ile Gly Ser Tyr Ser Gly Leu Gly Cys 
            260                 265 


<210>  599
<211>  308
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-Y17 (w/sig. seq.))

<400>  599

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Lys Thr His Thr Cys Pro 
            20                  25                  30          


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
        35                  40                  45              


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
    50                  55                  60                  


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
65                  70                  75                  80  


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
                85                  90                  95      


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
            100                 105                 110         


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
        115                 120                 125             


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
    130                 135                 140                 


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
145                 150                 155                 160 


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
                165                 170                 175     


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
            180                 185                 190         


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
        195                 200                 205             


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
    210                 215                 220                 


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
225                 230                 235                 240 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp 
                245                 250                 255     


Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln 
            260                 265                 270         


Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
        275                 280                 285             


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr Ser 
    290                 295                 300                 


Gly Leu Gly Cys 
305             


<210>  600
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (NC2-CNP53mut2-Y17 (w/o sig. seq.))

<400>  600

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln Ser Gln Ala 
225                 230                 235                 240 


Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln Gln Tyr Lys 
                245                 250                 255     


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            260                 265                 270         


Asp Arg Ile Gly Ser Tyr Ser Gly Leu Gly Cys 
        275                 280             


<210>  601
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-Y17 (w/sig. seq.))

<400>  601

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Tyr Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  602
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANKK-Y17 (w/o sig. seq.))

<400>  602

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Lys Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  603
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-Y17 (w/sig. seq.))

<400>  603

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Lys Gly Ala Asn Gln Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Tyr Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  604
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-KGANQK-Y17 (w/o sig. seq.))

<400>  604

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Lys Gly Ala Asn Gln Lys Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  605
<211>  318
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-Y17 (w/sig. seq.))

<400>  605

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Asp Leu Gln Val Asp Thr Gln 
            260                 265                 270         


Ser Gln Ala Ala Trp Ala Gln Leu Leu Gln Glu His Pro Asn Ala Gln 
        275                 280                 285             


Gln Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
    290                 295                 300                 


Leu Lys Leu Asp Arg Ile Gly Ser Tyr Ser Gly Leu Gly Cys 
305                 310                 315             


<210>  606
<211>  293
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2-CNP53mut2-Y17 (w/o sig. seq.))

<400>  606

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Asp Leu Gln Val Asp Thr Gln Ser Gln Ala Ala Trp Ala Gln Leu Leu 
                245                 250                 255     


Gln Glu His Pro Asn Ala Gln Gln Tyr Lys Gly Ala Asn Lys Lys Gly 
            260                 265                 270         


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Tyr 
        275                 280                 285             


Ser Gly Leu Gly Cys 
    290             


<210>  607
<211>  300
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2 (w/sig. seq.))

<400>  607

Met Gly Val His Glu Cys Pro Ala Trp Leu Trp Leu Leu Leu Ser Leu 
1               5                   10                  15      


Leu Ser Leu Trp Pro Gly Ala Tyr Ala Asp Asp Asp Asp Asp Asp Asp 
            20                  25                  30          


Asp Asp Asp Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
        35                  40                  45              


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
    50                  55                  60                  


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
65                  70                  75                  80  


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
                85                  90                  95      


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
            100                 105                 110         


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
        115                 120                 125             


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
    130                 135                 140                 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
145                 150                 155                 160 


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn 
                165                 170                 175     


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
            180                 185                 190         


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
        195                 200                 205             


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
    210                 215                 220                 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
225                 230                 235                 240 


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
                245                 250                 255     


Ser Leu Ser Pro Gly Lys Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            260                 265                 270         


Gly Gly Gly Gly Ser Gly Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
        275                 280                 285             


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
    290                 295                 300 


<210>  608
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (D10-NC2 (w/o sig. seq.))

<400>  608

Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Lys Thr His Thr Cys 
1               5                   10                  15      


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
            20                  25                  30          


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
        35                  40                  45              


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
    50                  55                  60                  


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
65                  70                  75                  80  


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
                85                  90                  95      


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
            100                 105                 110         


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
        115                 120                 125             


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
    130                 135                 140                 


Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
145                 150                 155                 160 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
                165                 170                 175     


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
            180                 185                 190         


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
        195                 200                 205             


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
    210                 215                 220                 


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Gly Gly Gly 
225                 230                 235                 240 


Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Leu Ser 
                245                 250                 255     


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            260                 265                 270         


Leu Gly Cys 
        275 


<210>  609

<400>  609
000

<210>  610

<400>  610
000

<210>  611

<400>  611
000

<210>  612

<400>  612
000

<210>  613

<400>  613
000

<210>  614

<400>  614
000

<210>  615

<400>  615
000

<210>  616

<400>  616
000

<210>  617

<400>  617
000

<210>  618

<400>  618
000

<210>  619

<400>  619
000

<210>  620

<400>  620
000

<210>  621

<400>  621
000

<210>  622

<400>  622
000

<210>  623

<400>  623
000

<210>  624

<400>  624
000

<210>  625

<400>  625
000

<210>  626

<400>  626
000

<210>  627

<400>  627
000

<210>  628

<400>  628
000

<210>  629

<400>  629
000

<210>  630

<400>  630
000

<210>  631

<400>  631
000

<210>  632

<400>  632
000

<210>  633

<400>  633
000

<210>  634

<400>  634
000

<210>  635

<400>  635
000

<210>  636

<400>  636
000

<210>  637

<400>  637
000

<210>  638

<400>  638
000

<210>  639

<400>  639
000

<210>  640

<400>  640
000

<210>  641

<400>  641
000

<210>  642

<400>  642
000

<210>  643

<400>  643
000

<210>  644

<400>  644
000

<210>  645

<400>  645
000

<210>  646

<400>  646
000

<210>  647

<400>  647
000

<210>  648

<400>  648
000

<210>  649

<400>  649
000

<210>  650

<400>  650
000

<210>  651

<400>  651
000

<210>  652

<400>  652
000

<210>  653

<400>  653
000

<210>  654

<400>  654
000

<210>  655

<400>  655
000

<210>  656

<400>  656
000

<210>  657

<400>  657
000

<210>  658

<400>  658
000

<210>  659

<400>  659
000

<210>  660

<400>  660
000

<210>  661

<400>  661
000

<210>  662

<400>  662
000

<210>  663

<400>  663
000

<210>  664

<400>  664
000

<210>  665

<400>  665
000

<210>  666

<400>  666
000

<210>  667

<400>  667
000

<210>  668

<400>  668
000

<210>  669

<400>  669
000

<210>  670

<400>  670
000

<210>  671

<400>  671
000

<210>  672

<400>  672
000

<210>  673

<400>  673
000

<210>  674

<400>  674
000

<210>  675

<400>  675
000

<210>  676

<400>  676
000

<210>  677

<400>  677
000

<210>  678

<400>  678
000

<210>  679

<400>  679
000

<210>  680

<400>  680
000

<210>  681

<400>  681
000

<210>  682

<400>  682
000

<210>  683

<400>  683
000

<210>  684

<400>  684
000

<210>  685

<400>  685
000

<210>  686

<400>  686
000

<210>  687

<400>  687
000

<210>  688

<400>  688
000

<210>  689

<400>  689
000

<210>  690

<400>  690
000

<210>  691

<400>  691
000

<210>  692

<400>  692
000

<210>  693

<400>  693
000

<210>  694

<400>  694
000

<210>  695

<400>  695
000

<210>  696

<400>  696
000

<210>  697

<400>  697
000

<210>  698

<400>  698
000

<210>  699

<400>  699
000

<210>  700

<400>  700
000

<210>  701

<400>  701
000

<210>  702

<400>  702
000

<210>  703

<400>  703
000

<210>  704

<400>  704
000

<210>  705

<400>  705
000

<210>  706

<400>  706
000

<210>  707

<400>  707
000

<210>  708

<400>  708
000

<210>  709

<400>  709
000

<210>  710

<400>  710
000

<210>  711

<400>  711
000

<210>  712

<400>  712
000

<210>  713

<400>  713
000

<210>  714

<400>  714
000

<210>  715

<400>  715
000

<210>  716

<400>  716
000

<210>  717

<400>  717
000

<210>  718

<400>  718
000

<210>  719

<400>  719
000

<210>  720

<400>  720
000

<210>  721

<400>  721
000

<210>  722

<400>  722
000

<210>  723

<400>  723
000

<210>  724

<400>  724
000

<210>  725

<400>  725
000

<210>  726

<400>  726
000

<210>  727

<400>  727
000

<210>  728

<400>  728
000

<210>  729

<400>  729
000

<210>  730

<400>  730
000

<210>  731

<400>  731
000

<210>  732

<400>  732
000

<210>  733

<400>  733
000

<210>  734

<400>  734
000

<210>  735

<400>  735
000

<210>  736

<400>  736
000

<210>  737

<400>  737
000

<210>  738

<400>  738
000

<210>  739

<400>  739
000

<210>  740

<400>  740
000

<210>  741

<400>  741
000

<210>  742

<400>  742
000

<210>  743

<400>  743
000

<210>  744

<400>  744
000

<210>  745

<400>  745
000

<210>  746

<400>  746
000

<210>  747

<400>  747
000

<210>  748

<400>  748
000

<210>  749

<400>  749
000

<210>  750

<400>  750
000

<210>  751

<400>  751
000

<210>  752

<400>  752
000

<210>  753

<400>  753
000

<210>  754

<400>  754
000

<210>  755

<400>  755
000

<210>  756

<400>  756
000

<210>  757

<400>  757
000

<210>  758

<400>  758
000

<210>  759

<400>  759
000

<210>  760

<400>  760
000

<210>  761

<400>  761
000

<210>  762

<400>  762
000

<210>  763

<400>  763
000

<210>  764

<400>  764
000

<210>  765

<400>  765
000

<210>  766

<400>  766
000

<210>  767

<400>  767
000

<210>  768

<400>  768
000

<210>  769

<400>  769
000

<210>  770

<400>  770
000

<210>  771

<400>  771
000

<210>  772

<400>  772
000

<210>  773

<400>  773
000

<210>  774

<400>  774
000

<210>  775

<400>  775
000

<210>  776

<400>  776
000

<210>  777

<400>  777
000

<210>  778

<400>  778
000

<210>  779

<400>  779
000

<210>  780

<400>  780
000

<210>  781

<400>  781
000

<210>  782

<400>  782
000

<210>  783

<400>  783
000

<210>  784

<400>  784
000

<210>  785

<400>  785
000

<210>  786

<400>  786
000

<210>  787

<400>  787
000

<210>  788

<400>  788
000

<210>  789

<400>  789
000

<210>  790

<400>  790
000

<210>  791

<400>  791
000

<210>  792

<400>  792
000

<210>  793

<400>  793
000

<210>  794

<400>  794
000

<210>  795

<400>  795
000

<210>  796

<400>  796
000

<210>  797

<400>  797
000

<210>  798

<400>  798
000

<210>  799

<400>  799
000

<210>  800

<400>  800
000

<210>  801
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NC2st DNA Sequence

<400>  801
atgggcgtgc acgagtgtcc tgcctggctg tggctgctgc tgagcctgct gtctctgtgg       60

cctggcgcct acgccgcctc ttggagccac ccccagtttg agcagtctgg cggcggagga      120

ggcgagaacc tgtactttca gggcggcgac aagacccaca cctgtccccc ttgtcctgcc      180

cctgagctgc tgggcggacc cagcgtgttc ctgttccccc caaagcccaa ggacaccctg      240

atgatcagcc ggacccccga agtgacctgc gtggtggtgg acgtgtccca cgaggaccct      300

gaagtgaagt tcaattggta cgtggacggc gtggaggtgc acaacgccaa gaccaagccc      360

cgggaggaac agtacaacag cacctaccgg gtggtgtccg tgctgaccgt gctgcaccag      420

gactggctga acggcaaaga gtacaagtgc aaggtctcca acaaggccct gcctgccccc      480

atcgagaaaa ccatcagcaa ggccaagggc cagcccagag aaccccaggt gtacaccctg      540

ccccccagcc gggaggaaat gaccaagaac caggtgtccc tgacctgcct ggtgaagggc      600

ttctacccca gcgatatcgc cgtggagtgg gagagcaacg gccagcctga gaacaactac      660

aagaccaccc cccctgtgct ggacagcgac ggaagcttct tcctgtactc caaactgacc      720

gtggacaaga gccggtggca gcagggcaac gtgttcagct gcagcgtgat gcacgaggcc      780

ctgcacaacc actacaccca gaagtccctg agcctgtctc ctggcaaggg cggaggggga      840

agtggaggcg gaggaagcgg gggaggcgga agcggcggac tgagcaaggg ctgcttcggc      900

ctgaagctgg accggatcgg cagcatgagc ggcctgggct gctga                      945


<210>  802
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NC2B DNA Sequence

<400>  802
atgggcgtgc acgagtgtcc tgcctggctg tggctgctgc tgagcctgct gtctctgtgg       60

cctggcgcct acgccgacaa gacccacacc tgtccccctt gtcctgcccc tgagctgctg      120

ggcggaccca gcgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      180

acccccgaag tgacctgcgt ggtggtggac gtgtcccacg aggaccctga agtgaagttc      240

aattggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg ggaggaacag      300

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      360

ggcaaagagt acaagtgcaa ggtctccaac aaggccctgc ctgcccccat cgagaaaacc      420

atcagcaagg ccaagggcca gcccagagaa ccccaggtgt acaccctgcc ccccagccgg      480

gaggaaatga ccaagaacca ggtgtccctg acctgcctgg tgaagggctt ctaccccagc      540

gatatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccaccccc      600

cctgtgctgg acagcgacgg cagcttcttc ctgtactcca aactgaccgt ggacaagagc      660

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      720

tacacccaga agtccctgag cctgtctcct ggcaagggcg gagggggaag tggaggcgga      780

ggaagcgggg gaggcggaag cggcggactg agcaagggct gcttcggcct gaagctggac      840

cggatcggca gcatgagcgg cctgggctgc tga                                   873


<210>  803
<211>  891
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NC2B-22 DNA Sequence

<400>  803
atgggcgtgc acgagtgtcc tgcctggctg tggctgctgc tgagcctgct gtctctgtgg       60

cctggcgcct acgccgacaa gacccacacc tgtccccctt gtcctgcccc tgagctgctg      120

ggcggaccca gcgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      180

acccccgaag tgacctgcgt ggtggtggac gtgtcccacg aggaccctga agtgaagttc      240

aattggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg ggaggaacag      300

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      360

ggcaaagagt acaagtgcaa ggtctccaac aaggccctgc ctgcccccat cgagaaaacc      420

atcagcaagg ccaagggcca gcccagagaa ccccaggtgt acaccctgcc ccccagccgg      480

gaggaaatga ccaagaacca ggtgtccctg acctgcctgg tgaagggctt ctaccccagc      540

gatatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccaccccc      600

cctgtgctgg acagcgacgg cagcttcttc ctgtactcca aactgaccgt ggacaagagc      660

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      720

tacacccaga agtccctgag cctgtctcct ggcaagggcg gagggggaag tggaggcgga      780

ggaagcgggg gaggcggaag cggaggcgga ggatctggcg gcggactgag caagggctgc      840

ttcggcctga agctggaccg gatcggcagc atgagcggcc tgggctgctg a               891


<210>  804
<211>  909
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NC2B-28 DNA Sequence

<400>  804
atgggcgtgc acgagtgtcc tgcctggctg tggctgctgc tgagcctgct gtctctgtgg       60

cctggcgcct acgccgacaa gacccacacc tgtccccctt gtcctgcccc tgagctgctg      120

ggcggaccca gcgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      180

acccccgaag tgacctgcgt ggtggtggac gtgtcccacg aggaccctga agtgaagttc      240

aattggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg ggaggaacag      300

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      360

ggcaaagagt acaagtgcaa ggtctccaac aaggccctgc ctgcccccat cgagaaaacc      420

atcagcaagg ccaagggcca gcccagagaa ccccaggtgt acaccctgcc ccccagccgg      480

gaggaaatga ccaagaacca ggtgtccctg acctgcctgg tgaagggctt ctaccccagc      540

gatatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccaccccc      600

cctgtgctgg acagcgacgg cagcttcttc ctgtactcca aactgaccgt ggacaagagc      660

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      720

tacacccaga agtccctgag cctgtctcct ggcaagggcg gagggggaag tggaggcgga      780

ggaagcgggg gaggcggaag cggaggcgga ggatctggcg gcggaggaag tggcggaggc      840

ggactgagca agggctgctt cggcctgaag ctggaccgga tcggcagcat gagcggcctg      900

ggctgctga                                                              909


<210>  805
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NC2B-34 DNA Sequence

<400>  805
atgggcgtgc acgagtgtcc tgcctggctg tggctgctgc tgagcctgct gtctctgtgg       60

cctggcgcct acgccgacaa gacccacacc tgtccccctt gtcctgcccc tgagctgctg      120

ggcggaccca gcgtgttcct gttcccccca aagcccaagg acaccctgat gatcagccgg      180

acccccgaag tgacctgcgt ggtggtggac gtgtcccacg aggaccctga agtgaagttc      240

aattggtacg tggacggcgt ggaggtgcac aacgccaaga ccaagccccg ggaggaacag      300

tacaacagca cctaccgggt ggtgtccgtg ctgaccgtgc tgcaccagga ctggctgaac      360

ggcaaagagt acaagtgcaa ggtctccaac aaggccctgc ctgcccccat cgagaaaacc      420

atcagcaagg ccaagggcca gcccagagaa ccccaggtgt acaccctgcc ccccagccgg      480

gaggaaatga ccaagaacca ggtgtccctg acctgcctgg tgaagggctt ctaccccagc      540

gatatcgccg tggagtggga gagcaacggc cagcctgaga acaactacaa gaccaccccc      600

cctgtgctgg acagcgacgg cagcttcttc ctgtactcca aactgaccgt ggacaagagc      660

cggtggcagc agggcaacgt gttcagctgc agcgtgatgc acgaggccct gcacaaccac      720

tacacccaga agtccctgag cctgtctcct ggcaagggcg gagggggaag tggaggcgga      780

ggaagcgggg gaggcggaag cggaggcgga ggatctggcg gcggaggaag tggcggaggc      840

ggcagcggcg gagggggagg actgagcaag ggctgcttcg gcctgaagct ggaccggatc      900

ggcagcatga gcggcctggg ctgctga                                          927


<210>  806
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NC1 DNA Sequence

<400>  806
atgggcgtgc acgagtgtcc tgcctggctg tggctgctgc tgagcctgct gtctctgtgg       60

cctggcgcct acgccggcct gagcaagggc tgcttcggcc tgaagctgga ccggatcggc      120

agcatgtctg gcctgggctg tggaggcgga ggatctggcg gcggaggaag tggcggaggc      180

ggcagcggcg ataagaccca cacctgtccc ccttgtcctg cccctgagct gctgggcgga      240

cccagcgtgt tcctgttccc cccaaagccc aaggacaccc tgatgatcag ccggaccccc      300

gaagtgacct gcgtggtggt ggacgtgtcc cacgaggacc ctgaagtgaa gttcaattgg      360

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgggagga acagtacaac      420

agcacctacc gggtggtgtc cgtgctgacc gtgctgcacc aggactggct gaacggcaaa      480

gagtacaagt gcaaggtctc caacaaggcc ctgcctgccc ccatcgagaa aaccatcagc      540

aaggccaagg gccagcccag agaaccccag gtgtacaccc tgccccccag ccgggaggaa      600

atgaccaaga accaggtgtc cctgacctgc ctggtgaagg gcttctaccc cagcgatatc      660

gccgtggagt gggagagcaa cggccagcct gagaacaact acaagaccac cccccctgtg      720

ctggacagcg acggcagctt cttcctgtac tccaaactga ccgtggacaa gagccggtgg      780

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc      840

cagaagtccc tgagcctgtc tcctggcaag ggcggcgaga acctgtactt tcagggcagc      900

caccaccatc accatcacca ccatcatcac tga                                   933


<210>  807

<400>  807
000

<210>  808

<400>  808
000

<210>  809

<400>  809
000

<210>  810

<400>  810
000

<210>  811

<400>  811
000

<210>  812

<400>  812
000

<210>  813

<400>  813
000

<210>  814

<400>  814
000

<210>  815

<400>  815
000

<210>  816

<400>  816
000

<210>  817

<400>  817
000

<210>  818

<400>  818
000

<210>  819

<400>  819
000

<210>  820

<400>  820
000

<210>  821

<400>  821
000

<210>  822

<400>  822
000

<210>  823

<400>  823
000

<210>  824

<400>  824
000

<210>  825

<400>  825
000

<210>  826

<400>  826
000

<210>  827

<400>  827
000

<210>  828

<400>  828
000

<210>  829

<400>  829
000

<210>  830

<400>  830
000

<210>  831

<400>  831
000

<210>  832

<400>  832
000

<210>  833

<400>  833
000

<210>  834

<400>  834
000

<210>  835

<400>  835
000

<210>  836

<400>  836
000

<210>  837

<400>  837
000

<210>  838

<400>  838
000

<210>  839

<400>  839
000

<210>  840

<400>  840
000

<210>  841

<400>  841
000

<210>  842

<400>  842
000

<210>  843

<400>  843
000

<210>  844

<400>  844
000

<210>  845

<400>  845
000

<210>  846

<400>  846
000

<210>  847

<400>  847
000

<210>  848

<400>  848
000

<210>  849

<400>  849
000

<210>  850

<400>  850
000

<210>  851

<400>  851
000

<210>  852

<400>  852
000

<210>  853

<400>  853
000

<210>  854

<400>  854
000

<210>  855

<400>  855
000

<210>  856

<400>  856
000

<210>  857

<400>  857
000

<210>  858

<400>  858
000

<210>  859

<400>  859
000

<210>  860

<400>  860
000

<210>  861

<400>  861
000

<210>  862

<400>  862
000

<210>  863

<400>  863
000

<210>  864

<400>  864
000

<210>  865

<400>  865
000

<210>  866

<400>  866
000

<210>  867

<400>  867
000

<210>  868

<400>  868
000

<210>  869

<400>  869
000

<210>  870

<400>  870
000

<210>  871

<400>  871
000

<210>  872

<400>  872
000

<210>  873

<400>  873
000

<210>  874

<400>  874
000

<210>  875

<400>  875
000

<210>  876

<400>  876
000

<210>  877

<400>  877
000

<210>  878

<400>  878
000

<210>  879

<400>  879
000

<210>  880

<400>  880
000

<210>  881

<400>  881
000

<210>  882

<400>  882
000

<210>  883

<400>  883
000

<210>  884

<400>  884
000

<210>  885

<400>  885
000

<210>  886

<400>  886
000

<210>  887

<400>  887
000

<210>  888

<400>  888
000

<210>  889

<400>  889
000

<210>  890

<400>  890
000

<210>  891

<400>  891
000

<210>  892

<400>  892
000

<210>  893

<400>  893
000

<210>  894

<400>  894
000

<210>  895

<400>  895
000

<210>  896

<400>  896
000

<210>  897

<400>  897
000

<210>  898

<400>  898
000

<210>  899

<400>  899
000

<210>  900

<400>  900
000

<210>  901

<400>  901
000

<210>  902

<400>  902
000

<210>  903

<400>  903
000

<210>  904

<400>  904
000

<210>  905

<400>  905
000

<210>  906

<400>  906
000

<210>  907

<400>  907
000

<210>  908

<400>  908
000

<210>  909

<400>  909
000

<210>  910

<400>  910
000

<210>  911

<400>  911
000

<210>  912

<400>  912
000

<210>  913

<400>  913
000

<210>  914

<400>  914
000

<210>  915

<400>  915
000

<210>  916

<400>  916
000

<210>  917

<400>  917
000

<210>  918

<400>  918
000

<210>  919

<400>  919
000

<210>  920

<400>  920
000

<210>  921

<400>  921
000

<210>  922

<400>  922
000

<210>  923

<400>  923
000

<210>  924

<400>  924
000

<210>  925

<400>  925
000

<210>  926

<400>  926
000

<210>  927

<400>  927
000

<210>  928

<400>  928
000

<210>  929

<400>  929
000

<210>  930

<400>  930
000

<210>  931

<400>  931
000

<210>  932

<400>  932
000

<210>  933

<400>  933
000

<210>  934

<400>  934
000

<210>  935

<400>  935
000

<210>  936

<400>  936
000

<210>  937

<400>  937
000

<210>  938

<400>  938
000

<210>  939

<400>  939
000

<210>  940

<400>  940
000

<210>  941

<400>  941
000

<210>  942

<400>  942
000

<210>  943

<400>  943
000

<210>  944

<400>  944
000

<210>  945

<400>  945
000

<210>  946

<400>  946
000

<210>  947

<400>  947
000

<210>  948

<400>  948
000

<210>  949

<400>  949
000

<210>  950

<400>  950
000

<210>  951

<400>  951
000

<210>  952

<400>  952
000

<210>  953

<400>  953
000

<210>  954

<400>  954
000

<210>  955

<400>  955
000

<210>  956

<400>  956
000

<210>  957

<400>  957
000

<210>  958

<400>  958
000

<210>  959

<400>  959
000

<210>  960

<400>  960
000

<210>  961

<400>  961
000

<210>  962

<400>  962
000

<210>  963

<400>  963
000

<210>  964

<400>  964
000

<210>  965

<400>  965
000

<210>  966

<400>  966
000

<210>  967

<400>  967
000

<210>  968

<400>  968
000

<210>  969

<400>  969
000

<210>  970

<400>  970
000

<210>  971

<400>  971
000

<210>  972

<400>  972
000

<210>  973

<400>  973
000

<210>  974

<400>  974
000

<210>  975

<400>  975
000

<210>  976

<400>  976
000

<210>  977

<400>  977
000

<210>  978

<400>  978
000

<210>  979

<400>  979
000

<210>  980

<400>  980
000

<210>  981

<400>  981
000

<210>  982

<400>  982
000

<210>  983

<400>  983
000

<210>  984

<400>  984
000

<210>  985

<400>  985
000

<210>  986

<400>  986
000

<210>  987

<400>  987
000

<210>  988

<400>  988
000

<210>  989

<400>  989
000

<210>  990

<400>  990
000

<210>  991

<400>  991
000

<210>  992

<400>  992
000

<210>  993

<400>  993
000

<210>  994

<400>  994
000

<210>  995

<400>  995
000

<210>  996

<400>  996
000

<210>  997

<400>  997
000

<210>  998

<400>  998
000

<210>  999

<400>  999
000

<210>  1000

<400>  1000
000

<210>  1001
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1001

Gly Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu 
1               5                   10                  15      


Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25                  30          


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
        35                  40                  45              


Met Ser Gly Leu Gly Cys 
    50                  


<210>  1002
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1002

Pro Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu 
1               5                   10                  15      


Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25                  30          


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
        35                  40                  45              


Met Ser Gly Leu Gly Cys 
    50                  


<210>  1003
<211>  54
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1003

Met Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu 
1               5                   10                  15      


Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
            20                  25                  30          


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
        35                  40                  45              


Met Ser Gly Leu Gly Cys 
    50                  


<210>  1004
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1004

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu 
1               5                   10                  15      


Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
            20                  25                  30          


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Asn 
        35                  40                  45              


Ser Gly Leu Gly Cys 
    50              


<210>  1005
<211>  52
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1005

Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln 
1               5                   10                  15      


Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
            20                  25                  30          


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
        35                  40                  45              


Gly Leu Gly Cys 
    50          


<210>  1006
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1006

Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu 
1               5                   10                  15      


His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
            20                  25                  30          


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
        35                  40                  45              


Leu Gly Cys 
    50      


<210>  1007
<211>  50
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1007

Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His 
1               5                   10                  15      


Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
            20                  25                  30          


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
        35                  40                  45              


Gly Cys 
    50  


<210>  1008
<211>  49
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic construct (additional CNP variant)

<400>  1008

Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro 
1               5                   10                  15      


Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly 
            20                  25                  30          


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
        35                  40                  45              


Cys 
    


<210>  1009
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1009

Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn 
1               5                   10                  15      


Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
            20                  25                  30          


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45              


<210>  1010
<211>  47
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1010

Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala 
1               5                   10                  15      


Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe 
            20                  25                  30          


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45          


<210>  1011
<211>  46
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1011

Ser Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg 
1               5                   10                  15      


Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
            20                  25                  30          


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45      


<210>  1012
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1012

Arg Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys 
1               5                   10                  15      


Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
            20                  25                  30          


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  45  


<210>  1013
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1013

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr 
1               5                   10                  15      


Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
            20                  25                  30          


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40                  


<210>  1014
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1014

Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys 
1               5                   10                  15      


Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
            20                  25                  30          


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40              


<210>  1015
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1015

Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly 
1               5                   10                  15      


Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
            20                  25                  30          


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40          


<210>  1016
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1016

Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala 
1               5                   10                  15      


Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
            20                  25                  30          


Ile Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40      


<210>  1017
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1017

Arg Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn 
1               5                   10                  15      


Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
            20                  25                  30          


Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40  


<210>  1018
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1018

Leu Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  1019
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1019

Leu Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1020
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1020

Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  1021
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1021

His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  1022
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1022

Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys 
1               5                   10                  15      


Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
            20                  25                  30          


Gly Cys 
        


<210>  1023
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1023

Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly 
1               5                   10                  15      


Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly 
            20                  25                  30          


Cys 
    


<210>  1024
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1024

Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys 
1               5                   10                  15      


Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30          


<210>  1025
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1025

Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe 
1               5                   10                  15      


Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30      


<210>  1026
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1026

Lys Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly 
1               5                   10                  15      


Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  30  


<210>  1027
<211>  29
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1027

Tyr Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu 
1               5                   10                  15      


Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25                  


<210>  1028
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1028

Lys Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  1029
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1029

Gly Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1030
<211>  26
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1030

Ala Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp 
1               5                   10                  15      


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25      


<210>  1031
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1031

Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg 
1               5                   10                  15      


Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25  


<210>  1032
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1032

Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  1033
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1033

Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1034
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1034

Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
1               5                   10                  15      


Ser Gly Leu Gly Cys 
            20      


<210>  1035
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1035

Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
1               5                   10                  15      


Gly Leu Gly Cys 
            20  


<210>  1036
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1036

Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
1               5                   10                  15      


Leu Gly Cys 
            


<210>  1037
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1037

Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu 
1               5                   10                  15      


Gly Cys 
        


<210>  1038
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1038

Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Asn 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1039
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1039

Pro Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1040
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1040

Met Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1041
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1041

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1042
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1042

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Pro Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1043
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1043

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1044
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1044

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Gln 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1045
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1045

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Pro 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1046
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1046

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Asn Ser Gly Leu Gly Cys 
        35              


<210>  1047
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1047

Pro Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  1048
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1048

Met Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  1049
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1049

Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1050
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1050

Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Asn Ser Gly Leu Gly Cys 
            20                  25          


<210>  1051
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1051

Pro Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  1052
<211>  28
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1052

Met Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys 
1               5                   10                  15      


Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25              


<210>  1053
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1053

Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1054
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1054

Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Asn Ser Gly Leu Gly Cys 
        35              


<210>  1055
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1055

Pro Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  1056
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1056

Met Gly His Lys Ser Glu Val Ala His Arg Phe Lys Gly Ala Asn Lys 
1               5                   10                  15      


Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  1057
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1057

Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1058
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1058

Glu Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  1059
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1059

Gly Ala Asn Gln Gln Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1060
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1060

Gly Ala Asn Arg Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1061
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1061

Gly Ala Asn Pro Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1062
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1062

Gly Ala Asn Ser Ser Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1063
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1063

Gly Ala Asn Pro Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1064
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1064

Gly Ala Asn Arg Arg Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1065
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1065

Gly Ala Asn Gln Gln Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1066
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1066

Gly Ala Asn Ser Ser Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu 
1               5                   10                  15      


Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys 
            20                  25          


<210>  1067
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1067

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  1068
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1068

Ala Ala Trp Ala Arg Leu Leu Gln Glu His Pro Asn Ala Arg Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  1069
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1069

Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  1070
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1070

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Pro Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1071
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1071

Gly Gln Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Ala Asn Gln Lys 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1072
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1072

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1073
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1073

Glu Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
1               5                   10                  15      


Gly Ser Met Ser Gly Leu Gly Cys 
            20                  


<210>  1074
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1074

Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1075
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1075

Gly Leu Ser Arg Gly Cys Phe Gly Leu Arg Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1076
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Phe

<400>  1076

Gly Leu Ser Lys Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1077
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is 3-amino-2-phenylpropionic acid

<400>  1077

Gly Leu Ser Lys Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1078
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1078

Arg Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1079
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1079

Glu Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1080
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1080

Gly Leu Ser Lys Arg Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1081
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1081

Gly Leu Ser Lys Gln Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1082
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1082

Gly Leu Ser Lys Ser Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1083
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1083

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Ser Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1084
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1084

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Asn Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1085
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1085

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Arg Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1086
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Cit

<400>  1086

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Xaa Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1087
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1087

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Ser Leu Gly Cys 
            20          


<210>  1088
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1088

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Arg Leu Gly Cys 
            20          


<210>  1089
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1089

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Asn Leu Gly Cys 
            20          


<210>  1090
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1090

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Ser Cys 
            20          


<210>  1091
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1091

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Thr Cys 
            20          


<210>  1092
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1092

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Arg Cys 
            20          


<210>  1093
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  [CH2NH] bond between residues 6 and 7

<400>  1093

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1094
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is N-Me-Phe

<400>  1094

Gly Leu Ser Lys Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1095
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa is t-Bu-Gly

<400>  1095

Gly Leu Ser Lys Gly Cys Phe Xaa Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1096
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is NHCH2CH(Ph)CO

<400>  1096

Gly Leu Ser Lys Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1097
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1097

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gly Leu 
1               5                   10                  15      


Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  1098
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1098

Gly Glu Arg Ala Phe Lys Ala Trp Ala Val Ala Arg Leu Ser Gln Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1099
<211>  39
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1099

Gly Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg Gly Ala Asn Pro 
1               5                   10                  15      


Arg Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
            20                  25                  30          


Ser Met Ser Gly Leu Gly Cys 
        35                  


<210>  1100
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1100

Gly His His Ser His Glu Gln His Pro His Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1101
<211>  38
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1101

Gly Ala His His Pro His Glu His Asp Thr His Gly Ala Asn Gln Gln 
1               5                   10                  15      


Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
            20                  25                  30          


Met Ser Gly Leu Gly Cys 
        35              


<210>  1102
<211>  35
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1102

Phe Gly Ile Pro Met Asp Arg Ile Gly Arg Asn Pro Arg Gly Leu Ser 
1               5                   10                  15      


Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly 
            20                  25                  30          


Leu Gly Cys 
        35  


<210>  1103
<211>  40
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1103

Gly Lys Arg Thr Gly Gln Tyr Lys Leu Gly Ser Lys Thr Gly Pro Gly 
1               5                   10                  15      


Pro Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile 
            20                  25                  30          


Gly Ser Met Ser Gly Leu Gly Cys 
        35                  40  


<210>  1104
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1104

Ser Pro Lys Met Val Gln Gly Ser Gly Cys Phe Gly Leu Lys Leu Asp 
1               5                   10                  15      


Arg Ile Gly Ser Met Ser Gly Leu Gly Cys Lys Val Leu Arg Arg His 
            20                  25                  30          


<210>  1105
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1105

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1106
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1106

Gly Val Pro Gln Val Ser Thr Ser Thr Gly Ala Asn Gln Gln Gly Leu 
1               5                   10                  15      


Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser 
            20                  25                  30          


Gly Leu Gly Cys 
        35      


<210>  1107
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1107

Gly Gln Pro Ser Ser Ser Ser Gln Ser Thr Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1108
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1108

Gly Ser Thr Gly Gln Trp His Ser Glu Ser Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1109
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1109

Gly Gln Thr His Ser Ser Gly Thr Gln Ser Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1110
<211>  37
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1110

Gly Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ala Asn Gln Gln Gly 
1               5                   10                  15      


Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met 
            20                  25                  30          


Ser Gly Leu Gly Cys 
        35          


<210>  1111
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (6)..(7)
<223>  [CH2NH] bond between residues 6 and 7

<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is N-Me-Leu

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is N-Me-Leu

<400>  1111

Gly Leu Ser Lys Gly Cys Phe Gly Xaa Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Xaa Gly Cys 
            20          


<210>  1112
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is N-Me-Leu

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is N-Me-Leu

<400>  1112

Gly Leu Ser Lys Gly Cys Phe Gly Xaa Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Xaa Gly Cys 
            20          


<210>  1113
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is N-Me-Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is N-Me-Leu

<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is N-Me-Leu

<400>  1113

Gly Leu Ser Lys Gly Cys Phe Gly Xaa Lys Xaa Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Xaa Gly Cys 
            20          


<210>  1114
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is N-Me-Leu

<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is N-Me-Leu

<400>  1114

Gly Leu Ser Lys Gly Cys Phe Gly Xaa Lys Xaa Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1115
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1115

Gly Leu Ser Arg Gly Cys Tyr Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1116
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1116

Gly Leu Ser Arg Gly Cys Phe Val Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1117
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1117

Gly Leu Ser Arg Gly Cys Phe Ser Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1118
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1118

Gly Leu Ser Arg Gly Cys Phe Thr Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1119
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1119

Gly Leu Ser Arg Gly Cys Phe Gly Thr Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1120
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1120

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Arg Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1121
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  Xaa is Cit

<400>  1121

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Xaa Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1122
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1122

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Val Ser Gly Leu Gly Cys 
            20          


<210>  1123
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1123

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Val Gly Cys 
            20          


<210>  1124
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is t-Bu-Ala

<400>  1124

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Xaa Gly Cys 
            20          


<210>  1125
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1125

Glu Leu Ser Glu Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1126
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is pentanoic acid

<400>  1126

Xaa Glu Leu Ser Glu Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1127
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is heptanoic acid

<400>  1127

Xaa Glu Leu Ser Glu Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1128
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is pentanoic acid

<400>  1128

Xaa Glu Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1129
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa is heptanoic acid

<400>  1129

Xaa Glu Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly 
1               5                   10                  15      


Ser Met Ser Gly Leu Gly Cys 
            20              


<210>  1130
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (10)..(10)
<223>  Xaa is Cit

<400>  1130

Gly Leu Ser Lys Gly Cys Phe Gly Leu Xaa Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1131
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1131

Gly Leu Ser Lys Gly Cys Phe Gly Leu Gln Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1132
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1132

Gly Leu Ser Lys Gly Cys Phe Gly Leu Arg Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1133
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1133

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Asn Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1134
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1134

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Ser Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1135
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  All D-amino acids

<400>  1135

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1136
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (9)..(9)
<223>  Xaa is N-Me-Leu

<400>  1136

Gly Leu Ser Lys Gly Cys Phe Gly Xaa Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1137
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (11)..(11)
<223>  Xaa is N-Me-Leu

<400>  1137

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Xaa Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1138
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (20)..(20)
<223>  Xaa is N-Me-Leu

<400>  1138

Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Xaa Gly Cys 
            20          


<210>  1139
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is 3,4-dichloro-Phe

<400>  1139

Gly Leu Ser Gly Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1140
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is 3-Me-Phe

<400>  1140

Gly Leu Ser Gly Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1141
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1141

Gly Leu Ser Arg Ser Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1142
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1142

Gly Leu Ser Arg Arg Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1143
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1143

Gly Leu Ser Gly Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1144
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1144

Gly Leu Ser Gly Gly Cys Phe Gly Leu Ser Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1145
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1145

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Gln 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1146
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1146

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Asn Ser Gly Leu Gly Cys 
            20          


<210>  1147
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1147

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Ser Leu Gly Cys 
            20          


<210>  1148
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1148

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Arg Leu Gly Cys 
            20          


<210>  1149
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1149

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Arg Gly Cys 
            20          


<210>  1150
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1150

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Ser Cys 
            20          


<210>  1151
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1151

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Thr Cys 
            20          


<210>  1152
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1152

Gly Leu Ser Arg Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Arg Cys 
            20          


<210>  1153
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is D-Phe

<400>  1153

Gly Leu Ser Lys Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1154
<211>  22
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)


<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa is 3-Cl-Phe

<400>  1154

Gly Leu Ser Lys Gly Cys Xaa Gly Leu Lys Leu Asp Arg Ile Gly Ser 
1               5                   10                  15      


Met Ser Gly Leu Gly Cys 
            20          


<210>  1155
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (additional CNP variant)

<400>  1155

Arg Ser Ser Cys Phe Gly Gly Arg Ile Ser Arg Ile Gly Ala Cys Phe 
1               5                   10                  15      


Phe Phe Phe Phe 
            20  


<210>  1156

<400>  1156
000

<210>  1157

<400>  1157
000

<210>  1158

<400>  1158
000

<210>  1159

<400>  1159
000

<210>  1160

<400>  1160
000

<210>  1161

<400>  1161
000

<210>  1162

<400>  1162
000

<210>  1163

<400>  1163
000

<210>  1164

<400>  1164
000

<210>  1165

<400>  1165
000

<210>  1166

<400>  1166
000

<210>  1167

<400>  1167
000

<210>  1168

<400>  1168
000

<210>  1169

<400>  1169
000

<210>  1170

<400>  1170
000

<210>  1171

<400>  1171
000

<210>  1172

<400>  1172
000

<210>  1173

<400>  1173
000

<210>  1174

<400>  1174
000

<210>  1175

<400>  1175
000

<210>  1176

<400>  1176
000

<210>  1177

<400>  1177
000

<210>  1178

<400>  1178
000

<210>  1179

<400>  1179
000

<210>  1180

<400>  1180
000

<210>  1181

<400>  1181
000

<210>  1182

<400>  1182
000

<210>  1183

<400>  1183
000

<210>  1184

<400>  1184
000

<210>  1185

<400>  1185
000

<210>  1186

<400>  1186
000

<210>  1187

<400>  1187
000

<210>  1188

<400>  1188
000

<210>  1189

<400>  1189
000

<210>  1190

<400>  1190
000

<210>  1191

<400>  1191
000

<210>  1192

<400>  1192
000

<210>  1193

<400>  1193
000

<210>  1194

<400>  1194
000

<210>  1195

<400>  1195
000

<210>  1196

<400>  1196
000

<210>  1197

<400>  1197
000

<210>  1198

<400>  1198
000

<210>  1199

<400>  1199
000

<210>  1200

<400>  1200
000

<210>  1201
<211>  743
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (sTNALP-FcD10 w/sig. seq.)

<400>  1201

Met Val Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                565                 570                 575     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            580                 585                 590         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Asp Ile Asp Asp Asp 
                725                 730                 735     


Asp Asp Asp Asp Asp Asp Asp 
            740             


<210>  1202
<211>  502
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (hsTNALP (1-502))

<400>  1202

Met Val Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser 
            500         


<210>  1203

<400>  1203
000

<210>  1204
<211>  726
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (sTNALP-FcD10 w/o sig. seq.)

<400>  1204

Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 
1               5                   10                  15      


Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 
            20                  25                  30          


Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 
        35                  40                  45              


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 
    50                  55                  60                  


Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 
65                  70                  75                  80  


Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 
                85                  90                  95      


Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 
            100                 105                 110         


Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 
        115                 120                 125             


Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 
    130                 135                 140                 


Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 
145                 150                 155                 160 


Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 
                165                 170                 175     


Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 
            180                 185                 190         


His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 
        195                 200                 205             


Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 
    210                 215                 220                 


Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 
225                 230                 235                 240 


Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 
                245                 250                 255     


Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 
            260                 265                 270         


Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 
        275                 280                 285             


Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 
    290                 295                 300                 


Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 
305                 310                 315                 320 


His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 
                325                 330                 335     


Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 
            340                 345                 350         


Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 
        355                 360                 365             


Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 
    370                 375                 380                 


Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 
385                 390                 395                 400 


Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 
                405                 410                 415     


Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 
            420                 425                 430         


Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 
        435                 440                 445             


Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 
    450                 455                 460                 


His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 
465                 470                 475                 480 


Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
                485                 490                 495     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            500                 505                 510         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        515                 520                 525             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    530                 535                 540                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
545                 550                 555                 560 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                565                 570                 575     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            580                 585                 590         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        595                 600                 605             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    610                 615                 620                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
625                 630                 635                 640 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                645                 650                 655     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            660                 665                 670         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        675                 680                 685             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    690                 695                 700                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys Asp Ile Asp Asp Asp Asp 
705                 710                 715                 720 


Asp Asp Asp Asp Asp Asp 
                725     


<210>  1205
<211>  485
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (hsTNALP (18-502))

<400>  1205

Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 
1               5                   10                  15      


Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 
            20                  25                  30          


Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 
        35                  40                  45              


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 
    50                  55                  60                  


Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 
65                  70                  75                  80  


Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 
                85                  90                  95      


Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 
            100                 105                 110         


Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 
        115                 120                 125             


Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 
    130                 135                 140                 


Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 
145                 150                 155                 160 


Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 
                165                 170                 175     


Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 
            180                 185                 190         


His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 
        195                 200                 205             


Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 
    210                 215                 220                 


Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 
225                 230                 235                 240 


Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 
                245                 250                 255     


Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 
            260                 265                 270         


Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 
        275                 280                 285             


Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 
    290                 295                 300                 


Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 
305                 310                 315                 320 


His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 
                325                 330                 335     


Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 
            340                 345                 350         


Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 
        355                 360                 365             


Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 
    370                 375                 380                 


Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 
385                 390                 395                 400 


Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 
                405                 410                 415     


Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 
            420                 425                 430         


Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 
        435                 440                 445             


Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 
    450                 455                 460                 


His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 
465                 470                 475                 480 


Ala Pro Ala Ser Ser 
                485 


<210>  1206
<211>  524
<212>  PRT
<213>  Bos taurus

<400>  1206

Met Ile Ser Pro Phe Leu Leu Leu Ala Ile Gly Thr Cys Phe Ala Ser 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Gln Thr Leu Lys Asn Ala Leu Arg Leu Gln Thr Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Ser 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Lys Leu Glu Met Asp Lys Phe Pro Tyr Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Gln Arg Ser Gln Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ser Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met Tyr Asn Ile Lys Asp Ile Glu Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asn Leu Ile Asp Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Lys His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Asp Leu Leu Ala Leu Asp Pro His Ser Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Ala 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Met Ala Ile Arg Ile Leu 
305                 310                 315                 320 


Asn Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Gln Ala Ile Gly Gln Ala Gly Ala Met Thr Ser Val 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val Gln Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Arg Asp His 
                485                 490                 495     


Cys Ala Ser Ala Ser Ser Ser Gly Ser Pro Ser Pro Gly Pro Leu Leu 
            500                 505                 510         


Leu Leu Leu Ala Leu Leu Pro Leu Gly Ser Leu Phe 
        515                 520                 


<210>  1207
<211>  524
<212>  PRT
<213>  Felis catus

<400>  1207

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Gln Thr Leu Lys Asn Ala Leu Arg Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Val Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Tyr Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Gln Arg Thr Gln Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ser Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Val Arg Asp Ile Glu Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Met Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asn Leu Val Asp Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro Tyr Gly Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Ser Thr 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Ile Ala Ile Lys Ile Leu 
305                 310                 315                 320 


Ser Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Gln Ala Ile Gly Arg Ala Gly Ala Met Thr Ser Val 
        355                 360                 365             


Glu Asp Thr Leu Thr Ile Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ser Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Asp His 
                485                 490                 495     


Cys Ala Ser Ala Ser Ser Ala Gly Gly Pro Ser Pro Gly Pro Leu Phe 
            500                 505                 510         


Leu Leu Leu Ala Leu Pro Ser Leu Gly Ile Leu Phe 
        515                 520                 


<210>  1208
<211>  524
<212>  PRT
<213>  Homo sapiens

<400>  1208

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Ala Gly Ser Leu Ala Ala Gly Pro Leu Leu 
            500                 505                 510         


Leu Ala Leu Ala Leu Tyr Pro Leu Ser Val Leu Phe 
        515                 520                 


<210>  1209
<211>  524
<212>  PRT
<213>  Mus musculus

<400>  1209

Met Ile Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Phe Val Pro Glu Lys Glu Arg Asp Pro Ser Tyr Trp Arg Gln Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Asn Ala Leu Lys Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Thr Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Thr Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Lys Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Ile Ser Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Ala Leu Asp Pro Ser Arg Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Leu 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Val Ala Leu Arg Ile Leu 
305                 310                 315                 320 


Thr Lys Asn Leu Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Gln Ala Ile Gly Lys Ala Gly Ala Met Thr Ser Gln 
        355                 360                 365             


Lys Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Asp Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ser Cys Ile Gly Ala Asn Leu Asp His 
                485                 490                 495     


Cys Ala Trp Ala Gly Ser Gly Ser Ala Pro Ser Pro Gly Ala Leu Leu 
            500                 505                 510         


Leu Pro Leu Ala Val Leu Ser Leu Pro Thr Leu Phe 
        515                 520                 


<210>  1210
<211>  524
<212>  PRT
<213>  Rattus norvegicus

<400>  1210

Met Ile Leu Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Phe Val Pro Glu Lys Glu Lys Asp Pro Ser Tyr Trp Arg Gln Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Asn Ala Leu Lys Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Ile Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Thr Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Thr Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Lys Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Arg Thr Asp Val Glu Tyr Glu Leu Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Ile Ser Ile Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg His Lys His Ser His Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Ala Leu Asp Pro Ser Arg Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Leu 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Glu Val Ala Leu Arg Ile Leu 
305                 310                 315                 320 


Thr Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Glu Ala Ile Gly Lys Ala Gly Thr Met Thr Ser Gln 
        355                 360                 365             


Lys Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Val Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Asp Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Ile 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ser Cys Ile Gly Ala Asn Leu Asp His 
                485                 490                 495     


Cys Ala Trp Ala Ser Ser Ala Ser Ser Pro Ser Pro Gly Ala Leu Leu 
            500                 505                 510         


Leu Pro Leu Ala Leu Phe Pro Leu Arg Thr Leu Phe 
        515                 520                 


<210>  1211
<211>  502
<212>  PRT
<213>  Canis familiaris

<400>  1211

Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala Gln Gln Thr Leu Lys 
1               5                   10                  15      


Tyr Ala Leu Arg Leu Gln Asn Leu Asn Thr Asn Val Ala Lys Asn Val 
            20                  25                  30          


Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser Thr Val Thr Ala Thr 
        35                  40                  45              


Arg Ile Leu Lys Gly Gln Leu His His Asn Pro Gly Glu Glu Thr Arg 
    50                  55                  60                  


Leu Glu Met Asp Lys Phe Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn 
65                  70                  75                  80  


Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr Ala Thr Ala Tyr Leu 
                85                  90                  95      


Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly Val Ser Ala Ala Thr 
            100                 105                 110         


Gln Arg Thr His Cys Asn Thr Thr Gln Gly Asn Glu Val Thr Ser Ile 
        115                 120                 125             


Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val Gly Ile Val Thr Thr 
    130                 135                 140                 


Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala Tyr Ala His Ser Ala 
145                 150                 155                 160 


Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro Pro Glu Ala Leu Ser 
                165                 170                 175     


Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met His Asn Val Lys Asp 
            180                 185                 190         


Ile Glu Val Ile Met Gly Gly Gly Arg Lys Tyr Met Phe Pro Lys Asn 
        195                 200                 205             


Arg Thr Asp Val Glu Tyr Glu Met Asp Glu Lys Ser Thr Gly Ala Arg 
    210                 215                 220                 


Leu Asp Gly Leu Asn Leu Ile Asp Ile Trp Lys Asn Phe Lys Pro Arg 
225                 230                 235                 240 


His Lys His Ser His Tyr Val Trp Asn Arg Thr Glu Leu Leu Ala Leu 
                245                 250                 255     


Asp Pro Tyr Thr Val Asp Tyr Leu Leu Gly Leu Phe Asp Pro Gly Asp 
            260                 265                 270         


Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr Asp Pro Ser Leu Ser 
        275                 280                 285             


Glu Met Val Glu Ile Ala Ile Lys Ile Leu Ser Lys Lys Pro Arg Gly 
    290                 295                 300                 


Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp His Gly His His Glu 
305                 310                 315                 320 


Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val Glu Met Asp Arg Ala 
                325                 330                 335     


Ile Gly Lys Ala Gly Val Met Thr Ser Leu Glu Asp Thr Leu Thr Val 
            340                 345                 350         


Val Thr Ala Asp His Ser His Val Phe Thr Phe Gly Gly Tyr Thr Pro 
        355                 360                 365             


Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met Val Ser Asp Thr Asp 
    370                 375                 380                 


Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn Gly Pro Gly Tyr Lys 
385                 390                 395                 400 


Val Val Gly Gly Glu Arg Glu Asn Val Ser Met Val Asp Tyr Ala His 
                405                 410                 415     


Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu Arg His Glu Thr His 
            420                 425                 430         


Gly Gly Glu Asp Val Ala Val Phe Ala Lys Gly Pro Met Ala His Leu 
        435                 440                 445             


Leu His Gly Val His Glu Gln Asn Tyr Ile Pro His Val Met Ala Tyr 
    450                 455                 460                 


Ala Ala Cys Ile Gly Ala Asn Gln Asp His Cys Ala Ser Ala Ser Ser 
465                 470                 475                 480 


Ala Gly Gly Pro Ser Pro Gly Pro Leu Leu Leu Leu Leu Ala Leu Leu 
                485                 490                 495     


Pro Val Gly Ile Leu Phe 
            500         


<210>  1212
<211>  528
<212>  PRT
<213>  Homo sapiens

<400>  1212

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Val Ile Pro Ala Glu Glu Glu Asn Pro Ala Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Asp Ala Ala Lys Lys Leu Gln Pro Ile 
        35                  40                  45              


Gln Lys Val Ala Lys Asn Leu Ile Leu Phe Leu Gly Asp Gly Leu Gly 
    50                  55                  60                  


Val Pro Thr Val Thr Ala Thr Arg Ile Leu Lys Gly Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Pro Leu Ala Met Asp Arg Phe Pro Tyr Leu 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Asn Val Asp Arg Gln Val Pro Asp Ser Ala 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Gln Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Met Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Ala Asp Ala 
225                 230                 235                 240 


Ser Gln Asn Gly Ile Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Trp Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Met Gln Ala Ser Leu Asp Gln Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Thr Lys Tyr Glu Ile His Arg Asp Pro Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Tyr Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Gly Val Ala Tyr Gln Ala Leu Thr Glu Ala Val Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Thr Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Thr Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Ser Lys 
385                 390                 395                 400 


Ala Gln Asp Ser Lys Ala Tyr Thr Ser Ile Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Phe Asn Ser Gly Val Arg Pro Asp Val Asn Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Asp Tyr Gln Gln Gln Ala Ala Val Pro Leu Ser Ser 
        435                 440                 445             


Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Ser Phe Val Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Pro Ala Cys Thr Thr Asp Ala Ala His Pro Val Ala Ala Ser Leu 
            500                 505                 510         


Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Ala Ser Ala Ala Pro 
        515                 520                 525             


<210>  1213
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  1213

Met Gln Gly Pro Trp Val Leu Leu Leu Leu Gly Leu Arg Leu Gln Leu 
1               5                   10                  15      


Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp Phe Trp Asn 
            20                  25                  30          


Arg Gln Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu Gln Pro Ala 
        35                  40                  45              


Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp Gly Met Gly 
    50                  55                  60                  


Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Lys Lys Asp 
65                  70                  75                  80  


Lys Leu Gly Pro Glu Thr Phe Leu Ala Met Asp Arg Phe Pro Tyr Val 
                85                  90                  95      


Ala Leu Ser Lys Thr Tyr Ser Val Asp Lys His Val Pro Asp Ser Gly 
            100                 105                 110         


Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn Phe Gln Thr 
        115                 120                 125             


Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn Thr Thr Arg 
    130                 135                 140                 


Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys Ala Gly Lys 
145                 150                 155                 160 


Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala Ser Pro Ala 
                165                 170                 175     


Gly Ala Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser Asp Ala Asp 
            180                 185                 190         


Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile Ala Thr Gln 
        195                 200                 205             


Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Phe Pro Met Gly Thr Pro Asp Pro Glu Tyr Pro Asp Asp Tyr 
225                 230                 235                 240 


Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val Gln Glu Trp 
                245                 250                 255     


Leu Ala Lys His Gln Gly Ala Arg Tyr Val Trp Asn Arg Thr Glu Leu 
            260                 265                 270         


Leu Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met Gly Leu Phe 
        275                 280                 285             


Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser Thr Leu Asp 
    290                 295                 300                 


Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Leu Leu Leu Ser Arg 
305                 310                 315                 320 


Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg Ile Asp His 
                325                 330                 335     


Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu Thr Ile Met 
            340                 345                 350         


Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser Glu Glu Asp 
        355                 360                 365             


Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe Ser Phe Gly 
    370                 375                 380                 


Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala Pro Gly Lys 
385                 390                 395                 400 


Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly Asn Gly Pro 
                405                 410                 415     


Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr Glu Ser Glu 
            420                 425                 430         


Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro Leu Asp Gly 
        435                 440                 445             


Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg Gly Pro Gln 
    450                 455                 460                 


Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile Ala His Val 
465                 470                 475                 480 


Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys Asp Leu Ala 
                485                 490                 495     


Pro Arg Ala Gly Thr Thr Asp Ala Ala His Pro Gly Pro Ser Val Val 
            500                 505                 510         


Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu Leu Gly Thr 
        515                 520                 525             


Ala Thr Ala Pro 
    530         


<210>  1214
<211>  535
<212>  PRT
<213>  Homo sapiens

<400>  1214

Met Leu Gly Pro Cys Met Leu Leu Leu Leu Leu Leu Leu Gly Leu Arg 
1               5                   10                  15      


Leu Gln Leu Ser Leu Gly Ile Ile Pro Val Glu Glu Glu Asn Pro Asp 
            20                  25                  30          


Phe Trp Asn Arg Glu Ala Ala Glu Ala Leu Gly Ala Ala Lys Lys Leu 
        35                  40                  45              


Gln Pro Ala Gln Thr Ala Ala Lys Asn Leu Ile Ile Phe Leu Gly Asp 
    50                  55                  60                  


Gly Met Gly Val Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln 
65                  70                  75                  80  


Lys Lys Asp Lys Leu Gly Pro Glu Ile Pro Leu Ala Met Asp Arg Phe 
                85                  90                  95      


Pro Tyr Val Ala Leu Ser Lys Thr Tyr Asn Val Asp Lys His Val Pro 
            100                 105                 110         


Asp Ser Gly Ala Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Gly Asn 
        115                 120                 125             


Phe Gln Thr Ile Gly Leu Ser Ala Ala Ala Arg Phe Asn Gln Cys Asn 
    130                 135                 140                 


Thr Thr Arg Gly Asn Glu Val Ile Ser Val Met Asn Arg Ala Lys Lys 
145                 150                 155                 160 


Ala Gly Lys Ser Val Gly Val Val Thr Thr Thr Arg Val Gln His Ala 
                165                 170                 175     


Ser Pro Ala Gly Thr Tyr Ala His Thr Val Asn Arg Asn Trp Tyr Ser 
            180                 185                 190         


Asp Ala Asp Val Pro Ala Ser Ala Arg Gln Glu Gly Cys Gln Asp Ile 
        195                 200                 205             


Ala Thr Gln Leu Ile Ser Asn Met Asp Ile Asp Val Ile Leu Gly Gly 
    210                 215                 220                 


Gly Arg Lys Tyr Met Phe Arg Met Gly Thr Pro Asp Pro Glu Tyr Pro 
225                 230                 235                 240 


Asp Asp Tyr Ser Gln Gly Gly Thr Arg Leu Asp Gly Lys Asn Leu Val 
                245                 250                 255     


Gln Glu Trp Leu Ala Lys Arg Gln Gly Ala Arg Tyr Val Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Met Gln Ala Ser Leu Asp Pro Ser Val Thr His Leu Met 
        275                 280                 285             


Gly Leu Phe Glu Pro Gly Asp Met Lys Tyr Glu Ile His Arg Asp Ser 
    290                 295                 300                 


Thr Leu Asp Pro Ser Leu Met Glu Met Thr Glu Ala Ala Leu Arg Leu 
305                 310                 315                 320 


Leu Ser Arg Asn Pro Arg Gly Phe Phe Leu Phe Val Glu Gly Gly Arg 
                325                 330                 335     


Ile Asp His Gly His His Glu Ser Arg Ala Tyr Arg Ala Leu Thr Glu 
            340                 345                 350         


Thr Ile Met Phe Asp Asp Ala Ile Glu Arg Ala Gly Gln Leu Thr Ser 
        355                 360                 365             


Glu Glu Asp Thr Leu Ser Leu Val Thr Ala Asp His Ser His Val Phe 
    370                 375                 380                 


Ser Phe Gly Gly Tyr Pro Leu Arg Gly Ser Ser Ile Phe Gly Leu Ala 
385                 390                 395                 400 


Pro Gly Lys Ala Arg Asp Arg Lys Ala Tyr Thr Val Leu Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Val Leu Lys Asp Gly Ala Arg Pro Asp Val Thr 
            420                 425                 430         


Glu Ser Glu Ser Gly Ser Pro Glu Tyr Arg Gln Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Asp Glu Glu Thr His Ala Gly Glu Asp Val Ala Val Phe Ala Arg 
    450                 455                 460                 


Gly Pro Gln Ala His Leu Val His Gly Val Gln Glu Gln Thr Phe Ile 
465                 470                 475                 480 


Ala His Val Met Ala Phe Ala Ala Cys Leu Glu Pro Tyr Thr Ala Cys 
                485                 490                 495     


Asp Leu Ala Pro Pro Ala Gly Thr Thr Asp Ala Ala His Pro Gly Arg 
            500                 505                 510         


Ser Val Val Pro Ala Leu Leu Pro Leu Leu Ala Gly Thr Leu Leu Leu 
        515                 520                 525             


Leu Glu Thr Ala Thr Ala Pro 
    530                 535 


<210>  1215
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Consensus)


<220>
<221>  MISC_FEATURE
<222>  (1)..(27)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (32)..(33)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (35)..(37)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (39)..(41)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (43)..(44)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (46)..(47)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (50)..(56)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (67)..(67)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (82)..(86)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (90)..(91)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (99)..(100)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (116)..(117)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (130)..(131)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (139)..(143)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (153)..(153)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (155)..(158)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (161)..(162)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (180)..(182)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (186)..(188)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (195)..(197)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (199)..(200)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (202)..(204)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (214)..(215)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (217)..(218)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (221)..(221)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (232)..(237)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (239)..(239)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (245)..(248)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (255)..(256)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (258)..(260)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (262)..(274)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (279)..(279)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (281)..(288)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (290)..(291)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (297)..(297)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (301)..(302)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (305)..(306)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (308)..(311)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (316)..(316)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (319)..(321)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (323)..(325)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (327)..(331)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (334)..(334)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (336)..(336)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (349)..(350)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (352)..(353)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (356)..(356)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (358)..(361)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (363)..(363)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (366)..(367)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (370)..(371)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (374)..(375)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (379)..(380)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (390)..(390)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (395)..(396)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (399)..(399)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (407)..(411)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (413)..(413)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (415)..(416)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (418)..(419)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (428)..(431)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (433)..(433)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (435)..(436)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (438)..(446)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (448)..(449)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (451)..(451)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (456)..(457)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (461)..(461)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (469)..(470)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (473)..(473)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (477)..(477)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (481)..(481)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (484)..(487)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (494)..(494)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (496)..(507)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (509)..(524)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (526)..(532)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<220>
<221>  MISC_FEATURE
<222>  (534)..(541)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1214

<400>  1215

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Pro Xaa 
            20                  25                  30          


Xaa Trp Xaa Xaa Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Ala Xaa Xaa Leu 
        35                  40                  45              


Gln Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Asn Xaa Ile Xaa Phe Leu Gly 
    50                  55                  60                  


Asp Gly Xaa Gly Val Xaa Thr Val Thr Ala Xaa Arg Ile Leu Lys Gly 
65                  70                  75                  80  


Gln Xaa Xaa Xaa Xaa Xaa Gly Xaa Glu Xaa Xaa Leu Xaa Met Asp Xaa 
                85                  90                  95      


Phe Pro Xaa Xaa Ala Leu Ser Lys Thr Tyr Xaa Xaa Xaa Xaa Xaa Val 
            100                 105                 110         


Pro Asp Ser Xaa Xaa Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Xaa 
        115                 120                 125             


Asn Xaa Xaa Thr Xaa Gly Xaa Ser Ala Ala Xaa Xaa Xaa Xaa Xaa Cys 
    130                 135                 140                 


Asn Thr Thr Xaa Gly Asn Glu Val Xaa Ser Xaa Xaa Xaa Xaa Ala Lys 
145                 150                 155                 160 


Xaa Xaa Gly Lys Ser Val Gly Xaa Val Thr Thr Thr Arg Val Xaa His 
                165                 170                 175     


Ala Xaa Pro Xaa Xaa Xaa Tyr Ala His Xaa Xaa Xaa Arg Xaa Trp Tyr 
            180                 185                 190         


Ser Asp Xaa Xaa Xaa Pro Xaa Xaa Ala Xaa Xaa Xaa Gly Cys Xaa Asp 
        195                 200                 205             


Ile Ala Xaa Gln Leu Xaa Xaa Asn Xaa Xaa Asp Ile Xaa Val Ile Xaa 
    210                 215                 220                 


Gly Gly Gly Arg Lys Tyr Met Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Glu 
225                 230                 235                 240 


Tyr Xaa Xaa Asp Xaa Xaa Xaa Xaa Gly Xaa Arg Leu Asp Gly Xaa Xaa 
                245                 250                 255     


Leu Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Trp Asn Arg Thr Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Val Xaa Xaa Leu Xaa Gly Leu Phe Xaa Pro Gly Asp Xaa Xaa Tyr Glu 
    290                 295                 300                 


Xaa Xaa Arg Xaa Xaa Xaa Xaa Asp Pro Ser Leu Xaa Glu Met Xaa Xaa 
305                 310                 315                 320 


Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Gly Phe Xaa Leu Xaa 
                325                 330                 335     


Val Glu Gly Gly Arg Ile Asp His Gly His His Glu Xaa Xaa Ala Xaa 
            340                 345                 350         


Xaa Ala Leu Xaa Glu Xaa Xaa Xaa Xaa Asp Xaa Ala Ile Xaa Xaa Ala 
        355                 360                 365             


Gly Xaa Xaa Thr Ser Xaa Xaa Asp Thr Leu Xaa Xaa Val Thr Ala Asp 
    370                 375                 380                 


His Ser His Val Phe Xaa Phe Gly Gly Tyr Xaa Xaa Arg Gly Xaa Ser 
385                 390                 395                 400 


Ile Phe Gly Leu Ala Pro Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Xaa Xaa 
                405                 410                 415     


Thr Xaa Xaa Leu Tyr Gly Asn Gly Pro Gly Tyr Xaa Xaa Xaa Xaa Gly 
            420                 425                 430         


Xaa Arg Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa 
        435                 440                 445             


Xaa Gln Xaa Ala Val Pro Leu Xaa Xaa Glu Thr His Xaa Gly Glu Asp 
    450                 455                 460                 


Val Ala Val Phe Xaa Xaa Gly Pro Xaa Ala His Leu Xaa His Gly Val 
465                 470                 475                 480 


Xaa Glu Gln Xaa Xaa Xaa Xaa His Val Met Ala Xaa Ala Xaa Cys Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540     


<210>  1216
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Consensus)


<220>
<221>  MISC_FEATURE
<222>  (1)..(22)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (51)..(51)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (80)..(81)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (137)..(138)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (177)..(177)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (210)..(210)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (212)..(213)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (216)..(216)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (253)..(255)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (262)..(263)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (268)..(269)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (274)..(274)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (281)..(282)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (303)..(304)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (314)..(315)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (317)..(318)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (321)..(321)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (323)..(325)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (364)..(365)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (368)..(369)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (374)..(374)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (402)..(402)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (425)..(425)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (463)..(463)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (475)..(475)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (480)..(480)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (488)..(488)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (494)..(495)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (499)..(499)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (503)..(508)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (514)..(514)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<220>
<221>  MISC_FEATURE
<222>  (517)..(522)
<223>  Xaa can be any naturally occuring amino acid or any amino acid at
       the corresponding position in one of SEQ ID NOs: 1206-1211

<400>  1216

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Asp Pro Xaa Tyr Trp Arg Xaa Gln 
            20                  25                  30          


Ala Gln Xaa Thr Leu Lys Xaa Ala Leu Xaa Leu Gln Xaa Leu Asn Thr 
        35                  40                  45              


Asn Val Xaa Lys Asn Xaa Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Xaa Arg Ile Leu Lys Gly Gln Leu His His Xaa 
65                  70                  75                  80  


Xaa Gly Glu Glu Thr Xaa Leu Glu Met Asp Lys Phe Pro Xaa Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Xaa Arg Xaa Xaa Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Xaa Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Xaa Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met Xaa Asn Xaa Xaa Asp Ile Xaa Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Xaa Pro Lys Asn Xaa Thr Asp Val Glu Tyr Glu Xaa Asp Glu 
225                 230                 235                 240 


Lys Xaa Xaa Gly Xaa Arg Leu Asp Gly Leu Xaa Leu Xaa Xaa Xaa Trp 
                245                 250                 255     


Lys Xaa Phe Lys Pro Xaa Xaa Lys His Ser His Xaa Xaa Trp Asn Arg 
            260                 265                 270         


Thr Xaa Leu Leu Xaa Leu Asp Pro Xaa Xaa Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Xaa Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Xaa Xaa 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Xaa Xaa Ala Xaa Xaa Ile Leu 
305                 310                 315                 320 


Xaa Lys Xaa Xaa Xaa Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Xaa Ala Ile Gly Xaa Ala Gly Xaa Xaa Thr Ser Xaa 
        355                 360                 365             


Xaa Asp Thr Leu Thr Xaa Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Xaa Ser Asp Thr Asp Lys Lys Pro Phe Thr Xaa Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Xaa Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Xaa Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val Xaa Glu Gln Asn Tyr Xaa 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Xaa Cys Ile Gly Ala Asn Xaa Xaa His 
                485                 490                 495     


Cys Ala Xaa Ala Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Leu Xaa 
            500                 505                 510         


Leu Xaa Leu Ala Xaa Xaa Xaa Xaa Xaa Xaa Leu Phe 
        515                 520                 


<210>  1217
<211>  2232
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (hsTNALP-FcD10)

<400>  1217
atggtttcac cattcttagt actggccatt ggcacctgcc ttactaactc cttagtgcca       60

gagaaagaga aagaccccaa gtactggcga gaccaagcgc aagagacact gaaatatgcc      120

ctggagcttc agaagctcaa caccaacgtg gctaagaatg tcatcatgtt cctgggagat      180

gggatgggtg tctccacagt gacggctgcc cgcatcctca agggtcagct ccaccacaac      240

cctggggagg agaccaggct ggagatggac aagttcccct tcgtggccct ctccaagacg      300

tacaacacca atgcccaggt ccctgacagc gccggcaccg ccaccgccta cctgtgtggg      360

gtgaaggcca atgagggcac cgtgggggta agcgcagcca ctgagcgttc ccggtgcaac      420

accacccagg ggaacgaggt cacctccatc ctgcgctggg ccaaggacgc tgggaaatct      480

gtgggcattg tgaccaccac gagagtgaac catgccaccc ccagcgccgc ctacgcccac      540

tcggctgacc gggactggta ctcagacaac gagatgcccc ctgaggcctt gagccagggc      600

tgtaaggaca tcgcctacca gctcatgcat aacatcaggg acattgacgt gatcatgggg      660

ggtggccgga aatacatgta ccccaagaat aaaactgatg tggagtatga gagtgacgag      720

aaagccaggg gcacgaggct ggacggcctg gacctcgttg acacctggaa gagcttcaaa      780

ccgagataca agcactccca cttcatctgg aaccgcacgg aactcctgac ccttgacccc      840

cacaatgtgg actacctatt gggtctcttc gagccagggg acatgcagta cgagctgaac      900

aggaacaacg tgacggaccc gtcactctcc gagatggtgg tggtggccat ccagatcctg      960

cggaagaacc ccaaaggctt cttcttgctg gtggaaggag gcagaattga ccacgggcac     1020

catgaaggaa aagccaagca ggccctgcat gaggcggtgg agatggaccg ggccatcggg     1080

caggcaggca gcttgacctc ctcggaagac actctgaccg tggtcactgc ggaccattcc     1140

cacgtcttca catttggtgg atacaccccc cgtggcaact ctatctttgg tctggccccc     1200

atgctgagtg acacagacaa gaagcccttc actgccatcc tgtatggcaa tgggcctggc     1260

tacaaggtgg tgggcggtga acgagagaat gtctccatgg tggactatgc tcacaacaac     1320

taccaggcgc agtctgctgt gcccctgcgc cacgagaccc acggcgggga ggacgtggcc     1380

gtcttctcca agggccccat ggcgcacctg ctgcacggcg tccacgagca gaactacgtc     1440

ccccacgtga tggcgtatgc agcctgcatc ggggccaacc tcggccactg tgctcctgcc     1500

agctcgctta aggacaaaac tcacacatgc ccaccgtgcc cagcacctga actcctgggg     1560

ggaccgtcag tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc     1620

cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt caagttcaac     1680

tggtacgtgg acggcgtgga ggtgcataat gccaagacaa agccgcggga ggagcagtac     1740

aacagcacgt accgtgtggt cagcgtcctc accgtcctgc accaggactg gctgaatggc     1800

aaggagtaca agtgcaaggt ctccaacaaa gccctcccag cccccatcga gaaaaccatc     1860

tccaaagcca aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggag     1920

gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta tcccagcgac     1980

atcgccgtgg agtgggagag caatgggcag ccggagaaca actacaagac cacgcctccc     2040

gtgctggact ccgacggctc cttcttcctc tatagcaagc tcaccgtgga caagagcagg     2100

tggcagcagg ggaacgtctt ctcatgctcc gtgatgcatg aggctctgca caaccactac     2160

acgcagaaga gcctctccct gtctccgggt aaagatatcg atgacgatga cgatgacgat     2220

gacgatgact ag                                                         2232


<210>  1218
<211>  541
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Consensus)


<220>
<221>  MISC_FEATURE
<222>  (1)..(27)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (29)..(30)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (32)..(33)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (35)..(37)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (39)..(41)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (43)..(44)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (46)..(47)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (50)..(55)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (61)..(61)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (82)..(86)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (88)..(88)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (90)..(91)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (99)..(100)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (107)..(111)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (116)..(117)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (130)..(131)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (133)..(133)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (139)..(143)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (148)..(148)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (155)..(158)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (161)..(162)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (168)..(168)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (175)..(175)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (180)..(182)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (186)..(188)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (190)..(190)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (195)..(197)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (199)..(200)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (202)..(204)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (207)..(207)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (211)..(211)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (214)..(215)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (217)..(218)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (221)..(221)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (224)..(224)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (232)..(237)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (239)..(239)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (245)..(248)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (250)..(250)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (255)..(256)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (258)..(260)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (262)..(274)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (279)..(279)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (281)..(288)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (290)..(291)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (293)..(293)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (297)..(297)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (302)..(302)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (305)..(306)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (308)..(311)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (316)..(316)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (319)..(321)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (323)..(325)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (327)..(331)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (334)..(334)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (336)..(336)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (349)..(350)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (352)..(353)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (356)..(356)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (358)..(361)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (363)..(363)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (366)..(367)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (370)..(371)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (374)..(375)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (379)..(380)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (390)..(390)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (395)..(396)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (399)..(399)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (407)..(411)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (413)..(413)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (415)..(416)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (418)..(419)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (428)..(431)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (433)..(433)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (435)..(436)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (438)..(446)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (448)..(449)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (451)..(451)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (456)..(457)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (461)..(461)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (469)..(470)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (473)..(473)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (477)..(477)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (481)..(481)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (484)..(487)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (492)..(492)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (494)..(494)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (496)..(507)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (509)..(524)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (526)..(532)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (534)..(541)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<400>  1218

Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Glu Xaa Xaa Pro Xaa 
            20                  25                  30          


Xaa Trp Xaa Xaa Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Ala Xaa Xaa Leu 
        35                  40                  45              


Gln Xaa Xaa Xaa Xaa Xaa Xaa Ala Lys Asn Xaa Ile Xaa Phe Leu Gly 
    50                  55                  60                  


Asp Gly Met Gly Val Xaa Thr Val Thr Ala Xaa Arg Ile Leu Lys Gly 
65                  70                  75                  80  


Gln Xaa Xaa Xaa Xaa Xaa Gly Xaa Glu Xaa Xaa Leu Xaa Met Asp Xaa 
                85                  90                  95      


Phe Pro Xaa Xaa Ala Leu Ser Lys Thr Tyr Xaa Xaa Xaa Xaa Xaa Val 
            100                 105                 110         


Pro Asp Ser Xaa Xaa Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Xaa 
        115                 120                 125             


Asn Xaa Xaa Thr Xaa Gly Xaa Ser Ala Ala Xaa Xaa Xaa Xaa Xaa Cys 
    130                 135                 140                 


Asn Thr Thr Xaa Gly Asn Glu Val Thr Ser Xaa Xaa Xaa Xaa Ala Lys 
145                 150                 155                 160 


Xaa Xaa Gly Lys Ser Val Gly Xaa Val Thr Thr Thr Arg Val Xaa His 
                165                 170                 175     


Ala Xaa Pro Xaa Xaa Xaa Tyr Ala His Xaa Xaa Xaa Arg Xaa Trp Tyr 
            180                 185                 190         


Ser Asp Xaa Xaa Xaa Pro Xaa Xaa Ala Xaa Xaa Xaa Gly Cys Xaa Asp 
        195                 200                 205             


Ile Ala Xaa Gln Leu Xaa Xaa Asn Xaa Xaa Asp Ile Xaa Val Ile Xaa 
    210                 215                 220                 


Gly Gly Gly Arg Lys Tyr Met Xaa Xaa Xaa Xaa Xaa Xaa Asp Xaa Glu 
225                 230                 235                 240 


Tyr Xaa Xaa Asp Xaa Xaa Xaa Xaa Gly Xaa Arg Leu Asp Gly Xaa Xaa 
                245                 250                 255     


Leu Xaa Xaa Xaa Trp Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Trp Asn Arg Thr Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Val Xaa Xaa Leu Xaa Gly Leu Phe Xaa Pro Gly Asp Met Xaa Tyr Glu 
    290                 295                 300                 


Xaa Xaa Arg Xaa Xaa Xaa Xaa Asp Pro Ser Leu Xaa Glu Met Xaa Xaa 
305                 310                 315                 320 


Xaa Ala Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Gly Phe Xaa Leu Xaa 
                325                 330                 335     


Val Glu Gly Gly Arg Ile Asp His Gly His His Glu Xaa Xaa Ala Xaa 
            340                 345                 350         


Xaa Ala Leu Xaa Glu Xaa Xaa Xaa Xaa Asp Xaa Ala Ile Xaa Xaa Ala 
        355                 360                 365             


Gly Xaa Xaa Thr Ser Xaa Xaa Asp Thr Leu Xaa Xaa Val Thr Ala Asp 
    370                 375                 380                 


His Ser His Val Phe Xaa Phe Gly Gly Tyr Xaa Xaa Arg Gly Xaa Ser 
385                 390                 395                 400 


Ile Phe Gly Leu Ala Pro Xaa Xaa Xaa Xaa Xaa Asp Xaa Lys Xaa Xaa 
                405                 410                 415     


Thr Xaa Xaa Leu Tyr Gly Asn Gly Pro Gly Tyr Xaa Xaa Xaa Xaa Gly 
            420                 425                 430         


Xaa Arg Xaa Xaa Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa 
        435                 440                 445             


Xaa Gln Xaa Ala Val Pro Leu Xaa Xaa Glu Thr His Xaa Gly Glu Asp 
    450                 455                 460                 


Val Ala Val Phe Xaa Xaa Gly Pro Xaa Ala His Leu Xaa His Gly Val 
465                 470                 475                 480 


Xaa Glu Gln Xaa Xaa Xaa Xaa His Val Met Ala Xaa Ala Xaa Cys Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540     


<210>  1219
<211>  524
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (Consensus)


<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (14)..(16)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (70)..(70)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (80)..(81)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (135)..(135)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (137)..(138)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (157)..(157)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (177)..(177)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (210)..(210)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (212)..(213)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (227)..(227)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (231)..(231)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (238)..(238)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (242)..(243)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (245)..(245)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (251)..(251)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (253)..(255)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (258)..(258)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (262)..(263)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (268)..(269)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (274)..(274)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (277)..(277)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (281)..(282)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (291)..(291)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (303)..(304)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (314)..(315)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (317)..(318)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (321)..(321)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (323)..(325)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (357)..(357)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (361)..(361)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (364)..(365)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (368)..(369)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (374)..(374)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (402)..(402)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (412)..(412)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (425)..(425)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (463)..(463)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (475)..(475)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (480)..(480)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (488)..(488)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (494)..(495)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (499)..(499)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (501)..(501)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (503)..(508)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (510)..(510)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (512)..(512)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (514)..(514)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<220>
<221>  MISC_FEATURE
<222>  (517)..(522)
<223>  Xaa can be any naturally occurring amino acid but not an amino 
       acid corresponding to one or more pathogenic mutations provided 
       in Table 1

<400>  1219

Met Ile Xaa Pro Phe Leu Xaa Leu Ala Ile Gly Thr Cys Xaa Xaa Xaa 
1               5                   10                  15      


Ser Xaa Val Pro Glu Lys Glu Xaa Asp Pro Xaa Tyr Trp Arg Xaa Gln 
            20                  25                  30          


Ala Gln Xaa Thr Leu Lys Xaa Ala Leu Xaa Leu Gln Xaa Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Xaa Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Xaa Arg Ile Leu Lys Gly Gln Leu His His Xaa 
65                  70                  75                  80  


Xaa Gly Glu Glu Thr Xaa Leu Glu Met Asp Lys Phe Pro Xaa Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Xaa Arg Xaa Xaa Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Xaa Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Xaa Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met Xaa Asn Xaa Xaa Asp Ile Xaa Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Xaa Pro Lys Asn Xaa Thr Asp Val Glu Tyr Glu Xaa Asp Glu 
225                 230                 235                 240 


Lys Xaa Xaa Gly Xaa Arg Leu Asp Gly Leu Xaa Leu Xaa Xaa Xaa Trp 
                245                 250                 255     


Lys Xaa Phe Lys Pro Xaa Xaa Lys His Ser His Xaa Xaa Trp Asn Arg 
            260                 265                 270         


Thr Xaa Leu Leu Xaa Leu Asp Pro Xaa Xaa Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Xaa Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Xaa Xaa 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Xaa Xaa Ala Xaa Xaa Ile Leu 
305                 310                 315                 320 


Xaa Lys Xaa Xaa Xaa Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Xaa Ala Ile Gly Xaa Ala Gly Xaa Xaa Thr Ser Xaa 
        355                 360                 365             


Xaa Asp Thr Leu Thr Xaa Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Xaa Ser Asp Thr Asp Lys Lys Pro Phe Thr Xaa Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Xaa Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Xaa Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val Xaa Glu Gln Asn Tyr Xaa 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Xaa Cys Ile Gly Ala Asn Xaa Xaa His 
                485                 490                 495     


Cys Ala Xaa Ala Xaa Ser Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Leu Xaa 
            500                 505                 510         


Leu Xaa Leu Ala Xaa Xaa Xaa Xaa Xaa Xaa Leu Phe 
        515                 520                 


<210>  1220
<211>  731
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (sTNALP-Fc w/ sig. seq.)

<400>  1220

Met Val Ser Pro Phe Leu Val Leu Ala Ile Gly Thr Cys Leu Thr Asn 
1               5                   10                  15      


Ser Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln 
            20                  25                  30          


Ala Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr 
        35                  40                  45              


Asn Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val 
    50                  55                  60                  


Ser Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn 
65                  70                  75                  80  


Pro Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala 
                85                  90                  95      


Leu Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly 
            100                 105                 110         


Thr Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val 
        115                 120                 125             


Gly Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly 
    130                 135                 140                 


Asn Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser 
145                 150                 155                 160 


Val Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala 
                165                 170                 175     


Ala Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met 
            180                 185                 190         


Pro Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu 
        195                 200                 205             


Met His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys 
    210                 215                 220                 


Tyr Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu 
225                 230                 235                 240 


Lys Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp 
                245                 250                 255     


Lys Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg 
            260                 265                 270         


Thr Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly 
        275                 280                 285             


Leu Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val 
    290                 295                 300                 


Thr Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu 
305                 310                 315                 320 


Arg Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile 
                325                 330                 335     


Asp His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala 
            340                 345                 350         


Val Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser 
        355                 360                 365             


Glu Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr 
    370                 375                 380                 


Phe Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro 
385                 390                 395                 400 


Met Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly 
                405                 410                 415     


Asn Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser 
            420                 425                 430         


Met Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro 
        435                 440                 445             


Leu Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys 
    450                 455                 460                 


Gly Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val 
465                 470                 475                 480 


Pro His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His 
                485                 490                 495     


Cys Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro 
            500                 505                 510         


Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
        515                 520                 525             


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
    530                 535                 540                 


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 
545                 550                 555                 560 


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
                565                 570                 575     


Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
            580                 585                 590         


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
        595                 600                 605             


Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 
    610                 615                 620                 


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
625                 630                 635                 640 


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
                645                 650                 655     


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
            660                 665                 670         


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
        675                 680                 685             


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
    690                 695                 700                 


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
705                 710                 715                 720 


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
                725                 730     


<210>  1221
<211>  714
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct (sTNALP-Fc w/o sig. seq.)

<400>  1221

Leu Val Pro Glu Lys Glu Lys Asp Pro Lys Tyr Trp Arg Asp Gln Ala 
1               5                   10                  15      


Gln Glu Thr Leu Lys Tyr Ala Leu Glu Leu Gln Lys Leu Asn Thr Asn 
            20                  25                  30          


Val Ala Lys Asn Val Ile Met Phe Leu Gly Asp Gly Met Gly Val Ser 
        35                  40                  45              


Thr Val Thr Ala Ala Arg Ile Leu Lys Gly Gln Leu His His Asn Pro 
    50                  55                  60                  


Gly Glu Glu Thr Arg Leu Glu Met Asp Lys Phe Pro Phe Val Ala Leu 
65                  70                  75                  80  


Ser Lys Thr Tyr Asn Thr Asn Ala Gln Val Pro Asp Ser Ala Gly Thr 
                85                  90                  95      


Ala Thr Ala Tyr Leu Cys Gly Val Lys Ala Asn Glu Gly Thr Val Gly 
            100                 105                 110         


Val Ser Ala Ala Thr Glu Arg Ser Arg Cys Asn Thr Thr Gln Gly Asn 
        115                 120                 125             


Glu Val Thr Ser Ile Leu Arg Trp Ala Lys Asp Ala Gly Lys Ser Val 
    130                 135                 140                 


Gly Ile Val Thr Thr Thr Arg Val Asn His Ala Thr Pro Ser Ala Ala 
145                 150                 155                 160 


Tyr Ala His Ser Ala Asp Arg Asp Trp Tyr Ser Asp Asn Glu Met Pro 
                165                 170                 175     


Pro Glu Ala Leu Ser Gln Gly Cys Lys Asp Ile Ala Tyr Gln Leu Met 
            180                 185                 190         


His Asn Ile Arg Asp Ile Asp Val Ile Met Gly Gly Gly Arg Lys Tyr 
        195                 200                 205             


Met Tyr Pro Lys Asn Lys Thr Asp Val Glu Tyr Glu Ser Asp Glu Lys 
    210                 215                 220                 


Ala Arg Gly Thr Arg Leu Asp Gly Leu Asp Leu Val Asp Thr Trp Lys 
225                 230                 235                 240 


Ser Phe Lys Pro Arg Tyr Lys His Ser His Phe Ile Trp Asn Arg Thr 
                245                 250                 255     


Glu Leu Leu Thr Leu Asp Pro His Asn Val Asp Tyr Leu Leu Gly Leu 
            260                 265                 270         


Phe Glu Pro Gly Asp Met Gln Tyr Glu Leu Asn Arg Asn Asn Val Thr 
        275                 280                 285             


Asp Pro Ser Leu Ser Glu Met Val Val Val Ala Ile Gln Ile Leu Arg 
    290                 295                 300                 


Lys Asn Pro Lys Gly Phe Phe Leu Leu Val Glu Gly Gly Arg Ile Asp 
305                 310                 315                 320 


His Gly His His Glu Gly Lys Ala Lys Gln Ala Leu His Glu Ala Val 
                325                 330                 335     


Glu Met Asp Arg Ala Ile Gly Gln Ala Gly Ser Leu Thr Ser Ser Glu 
            340                 345                 350         


Asp Thr Leu Thr Val Val Thr Ala Asp His Ser His Val Phe Thr Phe 
        355                 360                 365             


Gly Gly Tyr Thr Pro Arg Gly Asn Ser Ile Phe Gly Leu Ala Pro Met 
    370                 375                 380                 


Leu Ser Asp Thr Asp Lys Lys Pro Phe Thr Ala Ile Leu Tyr Gly Asn 
385                 390                 395                 400 


Gly Pro Gly Tyr Lys Val Val Gly Gly Glu Arg Glu Asn Val Ser Met 
                405                 410                 415     


Val Asp Tyr Ala His Asn Asn Tyr Gln Ala Gln Ser Ala Val Pro Leu 
            420                 425                 430         


Arg His Glu Thr His Gly Gly Glu Asp Val Ala Val Phe Ser Lys Gly 
        435                 440                 445             


Pro Met Ala His Leu Leu His Gly Val His Glu Gln Asn Tyr Val Pro 
    450                 455                 460                 


His Val Met Ala Tyr Ala Ala Cys Ile Gly Ala Asn Leu Gly His Cys 
465                 470                 475                 480 


Ala Pro Ala Ser Ser Leu Lys Asp Lys Thr His Thr Cys Pro Pro Cys 
                485                 490                 495     


Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 
            500                 505                 510         


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
        515                 520                 525             


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
    530                 535                 540                 


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
545                 550                 555                 560 


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
                565                 570                 575     


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
            580                 585                 590         


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
        595                 600                 605             


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 
    610                 615                 620                 


Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
625                 630                 635                 640 


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
                645                 650                 655     


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
            660                 665                 670         


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
        675                 680                 685             


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
    690                 695                 700                 


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
705                 710                 


