                         SEQUENCE LISTING

<110>  Minerva Biotechnologies Corporation
 
<120>  MEDIA FOR STEM CELL PROLIFERATION AND INDUCTION

<130>  13150-70124PCT

<140>  PCT/US12/60684
<141>  2012-10-17

<160>  116   

<170>  PatentIn version 3.5

<210>  1
<211>  1255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  full-length MUC1 Receptor

<400>  1

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 
    50                  55                  60                  


Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu 
65                  70                  75                  80  


Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 
                85                  90                  95      


Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 
            100                 105                 110         


Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 
        115                 120                 125             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    130                 135                 140                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
145                 150                 155                 160 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                165                 170                 175     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            180                 185                 190         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        195                 200                 205             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    210                 215                 220                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
225                 230                 235                 240 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                245                 250                 255     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            260                 265                 270         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        275                 280                 285             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    290                 295                 300                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
305                 310                 315                 320 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                325                 330                 335     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            340                 345                 350         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        355                 360                 365             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    370                 375                 380                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
385                 390                 395                 400 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                405                 410                 415     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            420                 425                 430         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        435                 440                 445             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    450                 455                 460                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
465                 470                 475                 480 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                485                 490                 495     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            500                 505                 510         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        515                 520                 525             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    530                 535                 540                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
545                 550                 555                 560 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                565                 570                 575     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            580                 585                 590         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        595                 600                 605             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    610                 615                 620                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
625                 630                 635                 640 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                645                 650                 655     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            660                 665                 670         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        675                 680                 685             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    690                 695                 700                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
705                 710                 715                 720 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                725                 730                 735     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            740                 745                 750         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        755                 760                 765             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    770                 775                 780                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
785                 790                 795                 800 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                805                 810                 815     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            820                 825                 830         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        835                 840                 845             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 
    850                 855                 860                 


Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser 
865                 870                 875                 880 


Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 
                885                 890                 895     


Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 
            900                 905                 910         


Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 
        915                 920                 925             


Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 
    930                 935                 940                 


Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser 
945                 950                 955                 960 


Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 
                965                 970                 975     


Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 
            980                 985                 990         


Ser Ile Pro Ser His His Ser Asp  Thr Pro Thr Thr Leu  Ala Ser His 
        995                 1000                 1005             


Ser Thr  Lys Thr Asp Ala Ser  Ser Thr His His Ser  Ser Val Pro 
    1010                 1015                 1020             


Pro Leu  Thr Ser Ser Asn His  Ser Thr Ser Pro Gln  Leu Ser Thr 
    1025                 1030                 1035             


Gly Val  Ser Phe Phe Phe Leu  Ser Phe His Ile Ser  Asn Leu Gln 
    1040                 1045                 1050             


Phe Asn  Ser Ser Leu Glu Asp  Pro Ser Thr Asp Tyr  Tyr Gln Glu 
    1055                 1060                 1065             


Leu Gln  Arg Asp Ile Ser Glu  Met Phe Leu Gln Ile  Tyr Lys Gln 
    1070                 1075                 1080             


Gly Gly  Phe Leu Gly Leu Ser  Asn Ile Lys Phe Arg  Pro Gly Ser 
    1085                 1090                 1095             


Val Val  Val Gln Leu Thr Leu  Ala Phe Arg Glu Gly  Thr Ile Asn 
    1100                 1105                 1110             


Val His  Asp Val Glu Thr Gln  Phe Asn Gln Tyr Lys  Thr Glu Ala 
    1115                 1120                 1125             


Ala Ser  Arg Tyr Asn Leu Thr  Ile Ser Asp Val Ser  Val Ser Asp 
    1130                 1135                 1140             


Val Pro  Phe Pro Phe Ser Ala  Gln Ser Gly Ala Gly  Val Pro Gly 
    1145                 1150                 1155             


Trp Gly  Ile Ala Leu Leu Val  Leu Val Cys Val Leu  Val Ala Leu 
    1160                 1165                 1170             


Ala Ile  Val Tyr Leu Ile Ala  Leu Ala Val Cys Gln  Cys Arg Arg 
    1175                 1180                 1185             


Lys Asn  Tyr Gly Gln Leu Asp  Ile Phe Pro Ala Arg  Asp Thr Tyr 
    1190                 1195                 1200             


His Pro  Met Ser Glu Tyr Pro  Thr Tyr His Thr His  Gly Arg Tyr 
    1205                 1210                 1215             


Val Pro  Pro Ser Ser Thr Asp  Arg Ser Pro Tyr Glu  Lys Val Ser 
    1220                 1225                 1230             


Ala Gly  Asn Gly Gly Ser Ser  Leu Ser Tyr Thr Asn  Pro Ala Val 
    1235                 1240                 1245             


Ala Ala  Ala Ser Ala Asn Leu  
    1250                 1255 


<210>  2
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  2

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr 
            


<210>  3
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  3

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Ala 
            20              


<210>  4
<211>  23
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  N-terminal MUC-1 signaling sequence

<400>  4

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly 
            20              


<210>  5
<211>  146
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  truncated MUC1 receptor isoform having nat-PSMGFR at its 
       N-terminus

<400>  5

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro 
        35                  40                  45              


Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu 
    50                  55                  60                  


Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys 
65                  70                  75                  80  


Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro 
                85                  90                  95      


Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro 
            100                 105                 110         


Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly 
        115                 120                 125             


Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Ala Ser Ala 
    130                 135                 140                 


Asn Leu 
145     


<210>  6
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native Primary Sequence of the MUC1 Growth Factor Receptor

<400>  6

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  7
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Native Primary Sequence of the MUC1 Growth Factor Receptor

<400>  7

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  8
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  "SPY" functional variant of the native Primary Sequence of the 
       MUC1 Growth Factor Receptor

<400>  8

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  45  


<210>  9
<211>  44
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  SPY" functional variant of the native Primary Sequence of the 
       MUC1 Growth Factor Receptor

<400>  9

Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
1               5                   10                  15      


Glu Ala Ala Ser Pro Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
            20                  25                  30          


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala 
        35                  40                  


<210>  10
<211>  216
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  MUC1 cytoplasmic domain nucleotide sequence

<400>  10
tgtcagtgcc gccgaaagaa ctacgggcag ctggacatct ttccagcccg ggatacctac       60

catcctatga gcgagtaccc cacctaccac acccatgggc gctatgtgcc ccctagcagt      120

accgatcgta gcccctatga gaaggtttct gcaggtaacg gtggcagcag cctctcttac      180

acaaacccag cagtggcagc cgcttctgcc aacttg                                216


<210>  11
<211>  72
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MUC1 cytoplasmic domain amino acid sequence

<400>  11

Cys Gln Cys Arg Arg Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala 
1               5                   10                  15      


Arg Asp Thr Tyr His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His 
            20                  25                  30          


Gly Arg Tyr Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys 
        35                  40                  45              


Val Ser Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala 
    50                  55                  60                  


Val Ala Ala Ala Ser Ala Asn Leu 
65                  70          


<210>  12
<211>  854
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NME7 nucleotide sequence

<400>  12
gagatcctga gacaatgaat catagtgaaa gattcgtttt cattgcagag tggtatgatc       60

caaatgcttc acttcttcga cgttatgagc ttttatttta cccaggggat ggatctgttg      120

aaatgcatga tgtaaagaat catcgcacct ttttaaagcg gaccaaatat gataacctgc      180

acttggaaga tttatttata ggcaacaaag tgaatgtctt ttctcgacaa ctggtattaa      240

ttgactatgg ggatcaatat acagctcgcc agctgggcag taggaaagaa aaaacgctag      300

ccctaattaa accagatgca atatcaaagg ctggagaaat aattgaaata ataaacaaag      360

ctggatttac tataaccaaa ctcaaaatga tgatgctttc aaggaaagaa gcattggatt      420

ttcatgtaga tcaccagtca agaccctttt tcaatgagct gatccagttt attacaactg      480

gtcctattat tgccatggag attttaagag atgatgctat atgtgaatgg aaaagactgc      540

tgggacctgc aaactctgga gtggcacgca cagatgcttc tgaaagcatt agagccctct      600

ttggaacaga tggcataaga aatgcagcgc atggccctga ttcttttgct tctgcggcca      660

gagaaatgga gttgtttttt ccttcaagtg gaggttgtgg gccggcaaac actgctaaat      720

ttactaattg tacctgttgc attgttaaac cccatgctgt cagtgaaggt atgttgaata      780

cactatattc agtacatttt gttaatagga gagcaatgtt tattttcttg atgtacttta      840

tgtatagaaa ataa                                                        854


<210>  13
<211>  283
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NME7 amino acid sequence

<400>  13

Asp Pro Glu Thr Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu 
1               5                   10                  15      


Trp Tyr Asp Pro Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe 
            20                  25                  30          


Tyr Pro Gly Asp Gly Ser Val Glu Met His Asp Val Lys Asn His Arg 
        35                  40                  45              


Thr Phe Leu Lys Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu 
    50                  55                  60                  


Phe Ile Gly Asn Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile 
65                  70                  75                  80  


Asp Tyr Gly Asp Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu 
                85                  90                  95      


Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu 
            100                 105                 110         


Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys 
        115                 120                 125             


Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His 
    130                 135                 140                 


Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly 
145                 150                 155                 160 


Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp 
                165                 170                 175     


Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala 
            180                 185                 190         


Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala 
        195                 200                 205             


Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu 
    210                 215                 220                 


Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe 
225                 230                 235                 240 


Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
                245                 250                 255     


Met Leu Asn Thr Leu Tyr Ser Val His Phe Val Asn Arg Arg Ala Met 
            260                 265                 270         


Phe Ile Phe Leu Met Tyr Phe Met Tyr Arg Lys 
        275                 280             


<210>  14
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NM23-H1 nucleotide sequence

<400>  14
atggtgctac tgtctacttt agggatcgtc tttcaaggcg aggggcctcc tatctcaagc       60

tgtgatacag gaaccatggc caactgtgag cgtaccttca ttgcgatcaa accagatggg      120

gtccagcggg gtcttgtggg agagattatc aagcgttttg agcagaaagg attccgcctt      180

gttggtctga aattcatgca agcttccgaa gatcttctca aggaacacta cgttgacctg      240

aaggaccgtc cattctttgc cggcctggtg aaatacatgc actcagggcc ggtagttgcc      300

atggtctggg aggggctgaa tgtggtgaag acgggccgag tcatgctcgg ggagaccaac      360

cctgcagact ccaagcctgg gaccatccgt ggagacttct gcatacaagt tggcaggaac      420

attatacatg gcagtgattc tgtggagagt gcagagaagg agatcggctt gtggtttcac      480

cctgaggaac tggtagatta cacgagctgt gctcagaact ggatctatga atga            534


<210>  15
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NM23-H1 amino acid sequence

<400>  15

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Ser Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  16
<211>  534
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NM23-H1 S120G mutant nucleotide sequence

<400>  16
atggtgctac tgtctacttt agggatcgtc tttcaaggcg aggggcctcc tatctcaagc       60

tgtgatacag gaaccatggc caactgtgag cgtaccttca ttgcgatcaa accagatggg      120

gtccagcggg gtcttgtggg agagattatc aagcgttttg agcagaaagg attccgcctt      180

gttggtctga aattcatgca agcttccgaa gatcttctca aggaacacta cgttgacctg      240

aaggaccgtc cattctttgc cggcctggtg aaatacatgc actcagggcc ggtagttgcc      300

atggtctggg aggggctgaa tgtggtgaag acgggccgag tcatgctcgg ggagaccaac      360

cctgcagact ccaagcctgg gaccatccgt ggagacttct gcatacaagt tggcaggaac      420

attatacatg gcggtgattc tgtggagagt gcagagaagg agatcggctt gtggtttcac      480

cctgaggaac tggtagatta cacgagctgt gctcagaact ggatctatga atga            534


<210>  17
<211>  177
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NM23-H1 S120G mutant amino acid sequence

<400>  17

Met Val Leu Leu Ser Thr Leu Gly Ile Val Phe Gln Gly Glu Gly Pro 
1               5                   10                  15      


Pro Ile Ser Ser Cys Asp Thr Gly Thr Met Ala Asn Cys Glu Arg Thr 
            20                  25                  30          


Phe Ile Ala Ile Lys Pro Asp Gly Val Gln Arg Gly Leu Val Gly Glu 
        35                  40                  45              


Ile Ile Lys Arg Phe Glu Gln Lys Gly Phe Arg Leu Val Gly Leu Lys 
    50                  55                  60                  


Phe Met Gln Ala Ser Glu Asp Leu Leu Lys Glu His Tyr Val Asp Leu 
65                  70                  75                  80  


Lys Asp Arg Pro Phe Phe Ala Gly Leu Val Lys Tyr Met His Ser Gly 
                85                  90                  95      


Pro Val Val Ala Met Val Trp Glu Gly Leu Asn Val Val Lys Thr Gly 
            100                 105                 110         


Arg Val Met Leu Gly Glu Thr Asn Pro Ala Asp Ser Lys Pro Gly Thr 
        115                 120                 125             


Ile Arg Gly Asp Phe Cys Ile Gln Val Gly Arg Asn Ile Ile His Gly 
    130                 135                 140                 


Gly Asp Ser Val Glu Ser Ala Glu Lys Glu Ile Gly Leu Trp Phe His 
145                 150                 155                 160 


Pro Glu Glu Leu Val Asp Tyr Thr Ser Cys Ala Gln Asn Trp Ile Tyr 
                165                 170                 175     


Glu 
    


<210>  18
<211>  459
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  NM23-H2 nucleotide sequence

<400>  18
atggccaacc tggagcgcac cttcatcgcc atcaagccgg acggcgtgca gcgcggcctg       60

gtgggcgaga tcatcaagcg cttcgagcag aagggattcc gcctcgtggc catgaagttc      120

ctccgggcct ctgaagaaca cctgaagcag cactacattg acctgaaaga ccgaccattc      180

ttccctgggc tggtgaagta catgaactca gggccggttg tggccatggt ctgggagggg      240

ctgaacgtgg tgaagacagg ccgagtgatg cttggggaga ccaatccagc agattcaaag      300

ccaggcacca ttcgtgggga cttctgcatt caggttggca ggaacatcat tcatggcagt      360

gattcagtaa aaagtgctga aaaagaaatc agcctatggt ttaagcctga agaactggtt      420

gactacaagt cttgtgctca tgactgggtc tatgaataa                             459


<210>  19
<211>  152
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  NM23-H2 amino acid sequence

<400>  19

Met Ala Asn Leu Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Ala Met Lys Phe Leu Arg Ala Ser Glu Glu His Leu 
        35                  40                  45              


Lys Gln His Tyr Ile Asp Leu Lys Asp Arg Pro Phe Phe Pro Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met Asn Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Lys Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Ser Leu Trp Phe Lys Pro Glu Glu Leu Val Asp Tyr Lys Ser 
    130                 135                 140                 


Cys Ala His Asp Trp Val Tyr Glu 
145                 150         


<210>  20
<211>  1023
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NM23-H7-2 sequence optimized for E. coli 
       expression

<400>  20
atgcatgacg ttaaaaatca ccgtaccttt ctgaaacgca cgaaatatga taatctgcat       60

ctggaagacc tgtttattgg caacaaagtc aatgtgttct ctcgtcagct ggtgctgatc      120

gattatggcg accagtacac cgcgcgtcaa ctgggtagtc gcaaagaaaa aacgctggcc      180

ctgattaaac cggatgcaat ctccaaagct ggcgaaatta tcgaaattat caacaaagcg      240

ggtttcacca tcacgaaact gaaaatgatg atgctgagcc gtaaagaagc cctggatttt      300

catgtcgacc accagtctcg cccgtttttc aatgaactga ttcaattcat caccacgggt      360

ccgattatcg caatggaaat tctgcgtgat gacgctatct gcgaatggaa acgcctgctg      420

ggcccggcaa actcaggtgt tgcgcgtacc gatgccagtg aatccattcg cgctctgttt      480

ggcaccgatg gtatccgtaa tgcagcacat ggtccggact cattcgcatc ggcagctcgt      540

gaaatggaac tgtttttccc gagctctggc ggttgcggtc cggcaaacac cgccaaattt      600

accaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa      660

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      720

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      780

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      840

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      900

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      960

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttcaaaat tctggataat     1020

tga                                                                   1023


<210>  21
<211>  340
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NM23-H7-2 sequence optimized for E. coli expression

<400>  21

Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys Arg Thr Lys Tyr 
1               5                   10                  15      


Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn Lys Val Asn Val 
            20                  25                  30          


Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp Gln Tyr Thr Ala 
        35                  40                  45              


Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala Leu Ile Lys Pro 
    50                  55                  60                  


Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala 
65                  70                  75                  80  


Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu Ser Arg Lys Glu 
                85                  90                  95      


Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro Phe Phe Asn Glu 
            100                 105                 110         


Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala Met Glu Ile Leu 
        115                 120                 125             


Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn 
    130                 135                 140                 


Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe 
145                 150                 155                 160 


Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro Asp Ser Phe Ala 
                165                 170                 175     


Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys 
            180                 185                 190         


Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr Cys Cys Ile Val 
        195                 200                 205             


Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys Ile Leu Met Ala 
    210                 215                 220                 


Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln Met Phe Asn Met 
225                 230                 235                 240 


Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
                245                 250                 255     


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            260                 265                 270         


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        275                 280                 285             


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    290                 295                 300                 


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
305                 310                 315                 320 


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                325                 330                 335     


Ile Leu Asp Asn 
            340 


<210>  22
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A

<400>  22
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg tttttttga                             399


<210>  23
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A

<400>  23

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe 
    130         


<210>  24
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A1

<400>  24
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac ttga                                             444


<210>  25
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A1

<400>  25

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr 
145         


<210>  26
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A2

<400>  26
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

tttttttga                                                              669


<210>  27
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A2

<400>  27

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe 
    210                 215                 220         


<210>  28
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A3

<400>  28
atgaatcata gtgaaagatt cgttttcatt gcagagtggt atgatccaaa tgcttcactt       60

cttcgacgtt atgagctttt attttaccca ggggatggat ctgttgaaat gcatgatgta      120

aagaatcatc gcaccttttt aaagcggacc aaatatgata acctgcactt ggaagattta      180

tttataggca acaaagtgaa tgtcttttct cgacaactgg tattaattga ctatggggat      240

caatatacag ctcgccagct gggcagtagg aaagaaaaaa cgctagccct aattaaacca      300

gatgcaatat caaaggctgg agaaataatt gaaataataa acaaagctgg atttactata      360

accaaactca aaatgatgat gctttcaagg aaagaagcat tggattttca tgtagatcac      420

cagtcaagac cctttttcaa tgagctgatc cagtttatta caactggtcc tattattgcc      480

atggagattt taagagatga tgctatatgt gaatggaaaa gactgctggg acctgcaaac      540

tctggagtgg cacgcacaga tgcttctgaa agcattagag ccctctttgg aacagatggc      600

ataagaaatg cagcgcatgg ccctgattct tttgcttctg cggccagaga aatggagttg      660

ttttttcctt caagtggagg ttgtgggccg gcaaacactg ctaaatttac ttga            714


<210>  29
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A3

<400>  29

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
225                 230                 235         


<210>  30
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B

<400>  30
atgaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact gttgggaaag       60

atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat gttcaatatg      120

gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac cgaatatcat      180

gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca acagaataat      240

gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc ccggcattta      300

cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc tgttcactgt      360

actgatctgc cagaggatgg cctattagag gttcaatact tcttctga                   408


<210>  31
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B

<400>  31

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe 
    130                 135 


<210>  32
<211>  426
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B1

<400>  32
atgaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact gttgggaaag       60

atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat gttcaatatg      120

gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac cgaatatcat      180

gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca acagaataat      240

gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc ccggcattta      300

cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc tgttcactgt      360

actgatctgc cagaggatgg cctattagag gttcaatact tcttcaagat cttggataat      420

tagtga                                                                 426


<210>  33
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B1

<400>  33

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
    130                 135                 140 


<210>  34
<211>  446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B2

<400>  34
atgccttcaa gtggaggttg tgggccggca aacactgcta aatttactaa ttgtacctgt       60

tgcattgtta aaccccatgc tgtcagtgaa ggactgttgg gaaagatcct gatggctatc      120

cgagatgcag gttttgaaat ctcagctatg cagatgttca atatggatcg ggttaatgtt      180

gaggaattct atgaagttta taaaggagta gtgaccgaat atcatgacat ggtgacagaa      240

atgtattctg gcccttgtgt agcaatggag attcaacaga ataatgctac aaagacattt      300

cgagaatttt gtggacctgc tgatcctgaa attgcccggc atttacgccc tggaactctc      360

agagcaatct ttggtaaaac taagatccag aatgctgttc actgtactga tctgccagag      420

gatggcctat tagaggttca atactt                                           446


<210>  35
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B2

<400>  35

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe 
145                 150 


<210>  36
<211>  471
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B3

<400>  36
atgccttcaa gtggaggttg tgggccggca aacactgcta aatttactaa ttgtacctgt       60

tgcattgtta aaccccatgc tgtcagtgaa ggactgttgg gaaagatcct gatggctatc      120

cgagatgcag gttttgaaat ctcagctatg cagatgttca atatggatcg ggttaatgtt      180

gaggaattct atgaagttta taaaggagta gtgaccgaat atcatgacat ggtgacagaa      240

atgtattctg gcccttgtgt agcaatggag attcaacaga ataatgctac aaagacattt      300

cgagaatttt gtggacctgc tgatcctgaa attgcccggc atttacgccc tggaactctc      360

agagcaatct ttggtaaaac taagatccag aatgctgttc actgtactga tctgccagag      420

gatggcctat tagaggttca atacttcttc aagatcttgg ataattagtg a               471


<210>  37
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B3

<400>  37

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
145                 150                 155 


<210>  38
<211>  864
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-AB

<400>  38
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac taattgtacc tgttgcattg ttaaacccca tgctgtcagt      480

gaaggactgt tgggaaagat cctgatggct atccgagatg caggttttga aatctcagct      540

atgcagatgt tcaatatgga tcgggttaat gttgaggaat tctatgaagt ttataaagga      600

gtagtgaccg aatatcatga catggtgaca gaaatgtatt ctggcccttg tgtagcaatg      660

gagattcaac agaataatgc tacaaagaca tttcgagaat tttgtggacc tgctgatcct      720

gaaattgccc ggcatttacg ccctggaact ctcagagcaa tctttggtaa aactaagatc      780

cagaatgctg ttcactgtac tgatctgcca gaggatggcc tattagaggt tcaatacttc      840

ttcaagatct tggataatta gtga                                             864


<210>  39
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB

<400>  39

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
        275                 280                 285     


<210>  40
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-AB1

<400>  40
atggaaaaaa cgctagccct aattaaacca gatgcaatat caaaggctgg agaaataatt       60

gaaataataa acaaagctgg atttactata accaaactca aaatgatgat gctttcaagg      120

aaagaagcat tggattttca tgtagatcac cagtcaagac cctttttcaa tgagctgatc      180

cagtttatta caactggtcc tattattgcc atggagattt taagagatga tgctatatgt      240

gaatggaaaa gactgctggg acctgcaaac tctggagtgg cacgcacaga tgcttctgaa      300

agcattagag ccctctttgg aacagatggc ataagaaatg cagcgcatgg ccctgattct      360

tttgcttctg cggccagaga aatggagttg ttttttcctt caagtggagg ttgtgggccg      420

gcaaacactg ctaaatttac taattgtacc tgttgcattg ttaaacccca tgctgtcagt      480

gaaggactgt tgggaaagat cctgatggct atccgagatg caggttttga aatctcagct      540

atgcagatgt tcaatatgga tcgggttaat gttgaggaat tctatgaagt ttataaagga      600

gtagtgaccg aatatcatga catggtgaca gaaatgtatt ctggcccttg tgtagcaatg      660

gagattcaac agaataatgc tacaaagaca tttcgagaat tttgtggacc tgctgatcct      720

gaaattgccc ggcatttacg ccctggaact ctcagagcaa tctttggtaa aactaagatc      780

cagaatgctg ttcactgtac tgatctgcca gaggatggcc tattagaggt tcaatacttc      840

ttctga                                                                 846


<210>  41
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB1

<400>  41

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe 
        275                 280     


<210>  42
<211>  399
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A sequence optimized for E. coli 
       expression

<400>  42
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttctga                             399


<210>  43
<211>  132
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A sequence optimized for E. coli expression

<400>  43

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe 
    130         


<210>  44
<211>  444
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A1 sequence optimized for E. coli 
       expression

<400>  44
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac ctga                                             444


<210>  45
<211>  147
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A1 sequence optimized for E. coli expression

<400>  45

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr 
145         


<210>  46
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A2 sequence optimized for E. coli 
       expression

<400>  46
atgaatcact ccgaacgctt tgtttttatc gccgaatggt atgacccgaa tgcttccctg       60

ctgcgccgct acgaactgct gttttatccg ggcgatggta gcgtggaaat gcatgacgtt      120

aaaaatcacc gtacctttct gaaacgcacg aaatatgata atctgcatct ggaagacctg      180

tttattggca acaaagtcaa tgtgttctct cgtcagctgg tgctgatcga ttatggcgac      240

cagtacaccg cgcgtcaact gggtagtcgc aaagaaaaaa cgctggccct gattaaaccg      300

gatgcaatct ccaaagctgg cgaaattatc gaaattatca acaaagcggg tttcaccatc      360

acgaaactga aaatgatgat gctgagccgt aaagaagccc tggattttca tgtcgaccac      420

cagtctcgcc cgtttttcaa tgaactgatt caattcatca ccacgggtcc gattatcgca      480

atggaaattc tgcgtgatga cgctatctgc gaatggaaac gcctgctggg cccggcaaac      540

tcaggtgttg cgcgtaccga tgccagtgaa tccattcgcg ctctgtttgg caccgatggt      600

atccgtaatg cagcacatgg tccggactca ttcgcatcgg cagctcgtga aatggaactg      660

tttttctga                                                              669


<210>  47
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A2 sequence optimized for E. coli expression

<400>  47

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe 
    210                 215                 220         


<210>  48
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-A3 sequence optimized for E. coli 
       expression

<400>  48
atgaatcact ccgaacgctt tgtttttatc gccgaatggt atgacccgaa tgcttccctg       60

ctgcgccgct acgaactgct gttttatccg ggcgatggta gcgtggaaat gcatgacgtt      120

aaaaatcacc gtacctttct gaaacgcacg aaatatgata atctgcatct ggaagacctg      180

tttattggca acaaagtcaa tgtgttctct cgtcagctgg tgctgatcga ttatggcgac      240

cagtacaccg cgcgtcaact gggtagtcgc aaagaaaaaa cgctggccct gattaaaccg      300

gatgcaatct ccaaagctgg cgaaattatc gaaattatca acaaagcggg tttcaccatc      360

acgaaactga aaatgatgat gctgagccgt aaagaagccc tggattttca tgtcgaccac      420

cagtctcgcc cgtttttcaa tgaactgatt caattcatca ccacgggtcc gattatcgca      480

atggaaattc tgcgtgatga cgctatctgc gaatggaaac gcctgctggg cccggcaaac      540

tcaggtgttg cgcgtaccga tgccagtgaa tccattcgcg ctctgtttgg caccgatggt      600

atccgtaatg cagcacatgg tccggactca ttcgcatcgg cagctcgtga aatggaactg      660

tttttcccga gctctggcgg ttgcggtccg gcaaacaccg ccaaatttac ctga            714


<210>  49
<211>  237
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-A3 sequence optimized for E. coli expression

<400>  49

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
225                 230                 235         


<210>  50
<211>  408
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B sequence optimized for E. coli 
       expression

<400>  50
atgaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa       60

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      120

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      180

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      240

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      300

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      360

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttctga                   408


<210>  51
<211>  135
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B sequence optimized for E. coli expression

<400>  51

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe 
    130                 135 


<210>  52
<211>  423
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B1 sequence optimized for E. coli 
       expression

<400>  52
atgaattgta cgtgctgtat tgtcaaaccg cacgcagtgt cagaaggcct gctgggtaaa       60

attctgatgg caatccgtga tgctggcttt gaaatctcgg ccatgcagat gttcaacatg      120

gaccgcgtta acgtcgaaga attctacgaa gtttacaaag gcgtggttac cgaatatcac      180

gatatggtta cggaaatgta ctccggtccg tgcgtcgcga tggaaattca gcaaaacaat      240

gccaccaaaa cgtttcgtga attctgtggt ccggcagatc cggaaatcgc acgtcatctg      300

cgtccgggta ccctgcgcgc aatttttggt aaaacgaaaa tccagaacgc tgtgcactgt      360

accgatctgc cggaagacgg tctgctggaa gttcaatact ttttcaaaat tctggataat      420

tga                                                                    423


<210>  53
<211>  140
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B1 sequence optimized for E. coli expression

<400>  53

Met Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly 
1               5                   10                  15      


Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile 
            20                  25                  30          


Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe 
        35                  40                  45              


Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr 
    50                  55                  60                  


Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn 
65                  70                  75                  80  


Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile 
                85                  90                  95      


Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr 
            100                 105                 110         


Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu 
        115                 120                 125             


Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
    130                 135                 140 


<210>  54
<211>  453
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B2 sequence optimized for E. coli 
       expression

<400>  54
atgccgagct ctggcggttg cggtccggca aacaccgcca aatttaccaa ttgtacgtgc       60

tgtattgtca aaccgcacgc agtgtcagaa ggcctgctgg gtaaaattct gatggcaatc      120

cgtgatgctg gctttgaaat ctcggccatg cagatgttca acatggaccg cgttaacgtc      180

gaagaattct acgaagttta caaaggcgtg gttaccgaat atcacgatat ggttacggaa      240

atgtactccg gtccgtgcgt cgcgatggaa attcagcaaa acaatgccac caaaacgttt      300

cgtgaattct gtggtccggc agatccggaa atcgcacgtc atctgcgtcc gggtaccctg      360

cgcgcaattt ttggtaaaac gaaaatccag aacgctgtgc actgtaccga tctgccggaa      420

gacggtctgc tggaagttca atactttttc tga                                   453


<210>  55
<211>  150
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B2 sequence optimized for E. coli expression

<400>  55

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe 
145                 150 


<210>  56
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-B3 sequence optimized for E. coli 
       expression

<400>  56
atgccgagct ctggcggttg cggtccggca aacaccgcca aatttaccaa ttgtacgtgc       60

tgtattgtca aaccgcacgc agtgtcagaa ggcctgctgg gtaaaattct gatggcaatc      120

cgtgatgctg gctttgaaat ctcggccatg cagatgttca acatggaccg cgttaacgtc      180

gaagaattct acgaagttta caaaggcgtg gttaccgaat atcacgatat ggttacggaa      240

atgtactccg gtccgtgcgt cgcgatggaa attcagcaaa acaatgccac caaaacgttt      300

cgtgaattct gtggtccggc agatccggaa atcgcacgtc atctgcgtcc gggtaccctg      360

cgcgcaattt ttggtaaaac gaaaatccag aacgctgtgc actgtaccga tctgccggaa      420

gacggtctgc tggaagttca atactttttc aaaattctgg ataattga                   468


<210>  57
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-B3 sequence optimized for E. coli expression

<400>  57

Met Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr 
1               5                   10                  15      


Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu 
            20                  25                  30          


Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser 
        35                  40                  45              


Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr 
    50                  55                  60                  


Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu 
65                  70                  75                  80  


Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala 
                85                  90                  95      


Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala 
            100                 105                 110         


Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys 
        115                 120                 125             


Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu 
    130                 135                 140                 


Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
145                 150                 155 


<210>  58
<211>  861
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-AB sequence optimized for E. coli 
       expression

<400>  58
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac caattgtacg tgctgtattg tcaaaccgca cgcagtgtca      480

gaaggcctgc tgggtaaaat tctgatggca atccgtgatg ctggctttga aatctcggcc      540

atgcagatgt tcaacatgga ccgcgttaac gtcgaagaat tctacgaagt ttacaaaggc      600

gtggttaccg aatatcacga tatggttacg gaaatgtact ccggtccgtg cgtcgcgatg      660

gaaattcagc aaaacaatgc caccaaaacg tttcgtgaat tctgtggtcc ggcagatccg      720

gaaatcgcac gtcatctgcg tccgggtacc ctgcgcgcaa tttttggtaa aacgaaaatc      780

cagaacgctg tgcactgtac cgatctgccg gaagacggtc tgctggaagt tcaatacttt      840

ttcaaaattc tggataattg a                                                861


<210>  59
<211>  286
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB sequence optimized for E. coli expression

<400>  59

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys Ile Leu Asp Asn 
        275                 280                 285     


<210>  60
<211>  846
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME7-AB1 sequence optimized for E. coli 
       expression

<400>  60
atggaaaaaa cgctggccct gattaaaccg gatgcaatct ccaaagctgg cgaaattatc       60

gaaattatca acaaagcggg tttcaccatc acgaaactga aaatgatgat gctgagccgt      120

aaagaagccc tggattttca tgtcgaccac cagtctcgcc cgtttttcaa tgaactgatt      180

caattcatca ccacgggtcc gattatcgca atggaaattc tgcgtgatga cgctatctgc      240

gaatggaaac gcctgctggg cccggcaaac tcaggtgttg cgcgtaccga tgccagtgaa      300

tccattcgcg ctctgtttgg caccgatggt atccgtaatg cagcacatgg tccggactca      360

ttcgcatcgg cagctcgtga aatggaactg tttttcccga gctctggcgg ttgcggtccg      420

gcaaacaccg ccaaatttac caattgtacg tgctgtattg tcaaaccgca cgcagtgtca      480

gaaggcctgc tgggtaaaat tctgatggca atccgtgatg ctggctttga aatctcggcc      540

atgcagatgt tcaacatgga ccgcgttaac gtcgaagaat tctacgaagt ttacaaaggc      600

gtggttaccg aatatcacga tatggttacg gaaatgtact ccggtccgtg cgtcgcgatg      660

gaaattcagc aaaacaatgc caccaaaacg tttcgtgaat tctgtggtcc ggcagatccg      720

gaaatcgcac gtcatctgcg tccgggtacc ctgcgcgcaa tttttggtaa aacgaaaatc      780

cagaacgctg tgcactgtac cgatctgccg gaagacggtc tgctggaagt tcaatacttt      840

ttctga                                                                 846


<210>  61
<211>  281
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME7-AB1 sequence optimized for E. coli expression

<400>  61

Met Glu Lys Thr Leu Ala Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala 
1               5                   10                  15      


Gly Glu Ile Ile Glu Ile Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys 
            20                  25                  30          


Leu Lys Met Met Met Leu Ser Arg Lys Glu Ala Leu Asp Phe His Val 
        35                  40                  45              


Asp His Gln Ser Arg Pro Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr 
    50                  55                  60                  


Thr Gly Pro Ile Ile Ala Met Glu Ile Leu Arg Asp Asp Ala Ile Cys 
65                  70                  75                  80  


Glu Trp Lys Arg Leu Leu Gly Pro Ala Asn Ser Gly Val Ala Arg Thr 
                85                  90                  95      


Asp Ala Ser Glu Ser Ile Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg 
            100                 105                 110         


Asn Ala Ala His Gly Pro Asp Ser Phe Ala Ser Ala Ala Arg Glu Met 
        115                 120                 125             


Glu Leu Phe Phe Pro Ser Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala 
    130                 135                 140                 


Lys Phe Thr Asn Cys Thr Cys Cys Ile Val Lys Pro His Ala Val Ser 
145                 150                 155                 160 


Glu Gly Leu Leu Gly Lys Ile Leu Met Ala Ile Arg Asp Ala Gly Phe 
                165                 170                 175     


Glu Ile Ser Ala Met Gln Met Phe Asn Met Asp Arg Val Asn Val Glu 
            180                 185                 190         


Glu Phe Tyr Glu Val Tyr Lys Gly Val Val Thr Glu Tyr His Asp Met 
        195                 200                 205             


Val Thr Glu Met Tyr Ser Gly Pro Cys Val Ala Met Glu Ile Gln Gln 
    210                 215                 220                 


Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro 
225                 230                 235                 240 


Glu Ile Ala Arg His Leu Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly 
                245                 250                 255     


Lys Thr Lys Ile Gln Asn Ala Val His Cys Thr Asp Leu Pro Glu Asp 
            260                 265                 270         


Gly Leu Leu Glu Val Gln Tyr Phe Phe 
        275                 280     


<210>  62
<211>  570
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Mouse NME6

<400>  62
atgacctcca tcttgcgaag tccccaagct cttcagctca cactagccct gatcaagcct       60

gatgcagttg cccacccact gatcctggag gctgttcatc agcagattct gagcaacaag      120

ttcctcattg tacgaacgag ggaactgcag tggaagctgg aggactgccg gaggttttac      180

cgagagcatg aagggcgttt tttctatcag cggctggtgg agttcatgac aagtgggcca      240

atccgagcct atatccttgc ccacaaagat gccatccaac tttggaggac actgatggga      300

cccaccagag tatttcgagc acgctatata gccccagatt caattcgtgg aagtttgggc      360

ctcactgaca cccgaaatac tacccatggc tcagactccg tggtttccgc cagcagagag      420

attgcagcct tcttccctga cttcagtgaa cagcgctggt atgaggagga ggaaccccag      480

ctgcggtgtg gtcctgtgca ctacagtcca gaggaaggta tccactgtgc agctgaaaca      540

ggaggccaca aacaacctaa caaaacctag                                       570


<210>  63
<211>  189
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Mouse NME6

<400>  63

Met Thr Ser Ile Leu Arg Ser Pro Gln Ala Leu Gln Leu Thr Leu Ala 
1               5                   10                  15      


Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu Ile Leu Glu Ala Val 
            20                  25                  30          


His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile Val Arg Thr Arg Glu 
        35                  40                  45              


Leu Gln Trp Lys Leu Glu Asp Cys Arg Arg Phe Tyr Arg Glu His Glu 
    50                  55                  60                  


Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe Met Thr Ser Gly Pro 
65                  70                  75                  80  


Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala Ile Gln Leu Trp Arg 
                85                  90                  95      


Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala Arg Tyr Ile Ala Pro 
            100                 105                 110         


Asp Ser Ile Arg Gly Ser Leu Gly Leu Thr Asp Thr Arg Asn Thr Thr 
        115                 120                 125             


His Gly Ser Asp Ser Val Val Ser Ala Ser Arg Glu Ile Ala Ala Phe 
    130                 135                 140                 


Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu Glu Glu Glu Pro Gln 
145                 150                 155                 160 


Leu Arg Cys Gly Pro Val His Tyr Ser Pro Glu Glu Gly Ile His Cys 
                165                 170                 175     


Ala Ala Glu Thr Gly Gly His Lys Gln Pro Asn Lys Thr 
            180                 185                 


<210>  64
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6

<400>  64
atgacccaga atctggggag tgagatggcc tcaatcttgc gaagccctca ggctctccag       60

ctcactctag ccctgatcaa gcctgacgca gtcgcccatc cactgattct ggaggctgtt      120

catcagcaga ttctaagcaa caagttcctg attgtacgaa tgagagaact actgtggaga      180

aaggaagatt gccagaggtt ttaccgagag catgaagggc gttttttcta tcagaggctg      240

gtggagttca tggccagcgg gccaatccga gcctacatcc ttgcccacaa ggatgccatc      300

cagctctgga ggacgctcat gggacccacc agagtgttcc gagcacgcca tgtggcccca      360

gattctatcc gtgggagttt cggcctcact gacacccgca acaccaccca tggttcggac      420

tctgtggttt cagccagcag agagattgca gccttcttcc ctgacttcag tgaacagcgc      480

tggtatgagg aggaagagcc ccagttgcgc tgtggccctg tgtgctatag cccagaggga      540

ggtgtccact atgtagctgg aacaggaggc ctaggaccag cctga                      585


<210>  65
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6

<400>  65

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr 
                165                 170                 175     


Ser Pro Glu Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly 
            180                 185                 190         


Pro Ala 
        


<210>  66
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 1

<400>  66
atgacccaga atctggggag tgagatggcc tcaatcttgc gaagccctca ggctctccag       60

ctcactctag ccctgatcaa gcctgacgca gtcgcccatc cactgattct ggaggctgtt      120

catcagcaga ttctaagcaa caagttcctg attgtacgaa tgagagaact actgtggaga      180

aaggaagatt gccagaggtt ttaccgagag catgaagggc gttttttcta tcagaggctg      240

gtggagttca tggccagcgg gccaatccga gcctacatcc ttgcccacaa ggatgccatc      300

cagctctgga ggacgctcat gggacccacc agagtgttcc gagcacgcca tgtggcccca      360

gattctatcc gtgggagttt cggcctcact gacacccgca acaccaccca tggttcggac      420

tctgtggttt cagccagcag agagattgca gccttcttcc ctgacttcag tgaacagcgc      480

tggtatgagg aggaagagcc ccagttgcgc tgtggccctg tgtga                      525


<210>  67
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 1

<400>  67

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
                165                 170                 


<210>  68
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 2

<400>  68
atgctcactc tagccctgat caagcctgac gcagtcgccc atccactgat tctggaggct       60

gttcatcagc agattctaag caacaagttc ctgattgtac gaatgagaga actactgtgg      120

agaaaggaag attgccagag gttttaccga gagcatgaag ggcgtttttt ctatcagagg      180

ctggtggagt tcatggccag cgggccaatc cgagcctaca tccttgccca caaggatgcc      240

atccagctct ggaggacgct catgggaccc accagagtgt tccgagcacg ccatgtggcc      300

ccagattcta tccgtgggag tttcggcctc actgacaccc gcaacaccac ccatggttcg      360

gactctgtgg tttcagccag cagagagatt gcagccttct tccctgactt cagtgaacag      420

cgctggtatg aggaggaaga gccccagttg cgctgtggcc ctgtgtga                   468


<210>  69
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 2

<400>  69

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
145                 150                 155 


<210>  70
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 3

<400>  70
atgctcactc tagccctgat caagcctgac gcagtcgccc atccactgat tctggaggct       60

gttcatcagc agattctaag caacaagttc ctgattgtac gaatgagaga actactgtgg      120

agaaaggaag attgccagag gttttaccga gagcatgaag ggcgtttttt ctatcagagg      180

ctggtggagt tcatggccag cgggccaatc cgagcctaca tccttgccca caaggatgcc      240

atccagctct ggaggacgct catgggaccc accagagtgt tccgagcacg ccatgtggcc      300

ccagattcta tccgtgggag tttcggcctc actgacaccc gcaacaccac ccatggttcg      360

gactctgtgg tttcagccag cagagagatt gcagccttct tccctgactt cagtgaacag      420

cgctggtatg aggaggaaga gccccagttg cgctgtggcc ctgtgtgcta tagcccagag      480

ggaggtgtcc actatgtagc tggaacagga ggcctaggac cagcctga                   528


<210>  71
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 3

<400>  71

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr Ser Pro Glu 
145                 150                 155                 160 


Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly Pro Ala 
                165                 170                 175 


<210>  72
<211>  585
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 sequence optimized for E. coli expression

<400>  72
atgacgcaaa atctgggctc ggaaatggca agtatcctgc gctccccgca agcactgcaa       60

ctgaccctgg ctctgatcaa accggacgct gttgctcatc cgctgattct ggaagcggtc      120

caccagcaaa ttctgagcaa caaatttctg atcgtgcgta tgcgcgaact gctgtggcgt      180

aaagaagatt gccagcgttt ttatcgcgaa catgaaggcc gtttctttta tcaacgcctg      240

gttgaattca tggcctctgg tccgattcgc gcatatatcc tggctcacaa agatgcgatt      300

cagctgtggc gtaccctgat gggtccgacg cgcgtctttc gtgcacgtca tgtggcaccg      360

gactcaatcc gtggctcgtt cggtctgacc gatacgcgca ataccacgca cggtagcgac      420

tctgttgtta gtgcgtcccg tgaaatcgcg gcctttttcc cggacttctc cgaacagcgt      480

tggtacgaag aagaagaacc gcaactgcgc tgtggcccgg tctgttattc tccggaaggt      540

ggtgtccatt atgtggcggg cacgggtggt ctgggtccgg catga                      585


<210>  73
<211>  194
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 sequence optimized for E. coli expression

<400>  73

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr 
                165                 170                 175     


Ser Pro Glu Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly 
            180                 185                 190         


Pro Ala 
        


<210>  74
<211>  525
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 1 sequence optimized for E. coli 
       expression

<400>  74
atgacgcaaa atctgggctc ggaaatggca agtatcctgc gctccccgca agcactgcaa       60

ctgaccctgg ctctgatcaa accggacgct gttgctcatc cgctgattct ggaagcggtc      120

caccagcaaa ttctgagcaa caaatttctg atcgtgcgta tgcgcgaact gctgtggcgt      180

aaagaagatt gccagcgttt ttatcgcgaa catgaaggcc gtttctttta tcaacgcctg      240

gttgaattca tggcctctgg tccgattcgc gcatatatcc tggctcacaa agatgcgatt      300

cagctgtggc gtaccctgat gggtccgacg cgcgtctttc gtgcacgtca tgtggcaccg      360

gactcaatcc gtggctcgtt cggtctgacc gatacgcgca ataccacgca cggtagcgac      420

tctgttgtta gtgcgtcccg tgaaatcgcg gcctttttcc cggacttctc cgaacagcgt      480

tggtacgaag aagaagaacc gcaactgcgc tgtggcccgg tctga                      525


<210>  75
<211>  174
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 1 sequence optimized for E. coli expression

<400>  75

Met Thr Gln Asn Leu Gly Ser Glu Met Ala Ser Ile Leu Arg Ser Pro 
1               5                   10                  15      


Gln Ala Leu Gln Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala 
            20                  25                  30          


His Pro Leu Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys 
        35                  40                  45              


Phe Leu Ile Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys 
    50                  55                  60                  


Gln Arg Phe Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu 
65                  70                  75                  80  


Val Glu Phe Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His 
                85                  90                  95      


Lys Asp Ala Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val 
            100                 105                 110         


Phe Arg Ala Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly 
        115                 120                 125             


Leu Thr Asp Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser 
    130                 135                 140                 


Ala Ser Arg Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg 
145                 150                 155                 160 


Trp Tyr Glu Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
                165                 170                 


<210>  76
<211>  468
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 2 sequence optimized for E. coli 
       expression

<400>  76
atgctgaccc tggctctgat caaaccggac gctgttgctc atccgctgat tctggaagcg       60

gtccaccagc aaattctgag caacaaattt ctgatcgtgc gtatgcgcga actgctgtgg      120

cgtaaagaag attgccagcg tttttatcgc gaacatgaag gccgtttctt ttatcaacgc      180

ctggttgaat tcatggcctc tggtccgatt cgcgcatata tcctggctca caaagatgcg      240

attcagctgt ggcgtaccct gatgggtccg acgcgcgtct ttcgtgcacg tcatgtggca      300

ccggactcaa tccgtggctc gttcggtctg accgatacgc gcaataccac gcacggtagc      360

gactctgttg ttagtgcgtc ccgtgaaatc gcggcctttt tcccggactt ctccgaacag      420

cgttggtacg aagaagaaga accgcaactg cgctgtggcc cggtctga                   468


<210>  77
<211>  155
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 2 sequence optimized for E. coli expression

<400>  77

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val 
145                 150                 155 


<210>  78
<211>  528
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Human NME6 3 sequence optimized for E. coli 
       expression

<400>  78
atgctgaccc tggctctgat caaaccggac gctgttgctc atccgctgat tctggaagcg       60

gtccaccagc aaattctgag caacaaattt ctgatcgtgc gtatgcgcga actgctgtgg      120

cgtaaagaag attgccagcg tttttatcgc gaacatgaag gccgtttctt ttatcaacgc      180

ctggttgaat tcatggcctc tggtccgatt cgcgcatata tcctggctca caaagatgcg      240

attcagctgt ggcgtaccct gatgggtccg acgcgcgtct ttcgtgcacg tcatgtggca      300

ccggactcaa tccgtggctc gttcggtctg accgatacgc gcaataccac gcacggtagc      360

gactctgttg ttagtgcgtc ccgtgaaatc gcggcctttt tcccggactt ctccgaacag      420

cgttggtacg aagaagaaga accgcaactg cgctgtggcc cggtctgtta ttctccggaa      480

ggtggtgtcc attatgtggc gggcacgggt ggtctgggtc cggcatga                   528


<210>  79
<211>  175
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Human NME6 3 sequence optimized for E. coli expression

<400>  79

Met Leu Thr Leu Ala Leu Ile Lys Pro Asp Ala Val Ala His Pro Leu 
1               5                   10                  15      


Ile Leu Glu Ala Val His Gln Gln Ile Leu Ser Asn Lys Phe Leu Ile 
            20                  25                  30          


Val Arg Met Arg Glu Leu Leu Trp Arg Lys Glu Asp Cys Gln Arg Phe 
        35                  40                  45              


Tyr Arg Glu His Glu Gly Arg Phe Phe Tyr Gln Arg Leu Val Glu Phe 
    50                  55                  60                  


Met Ala Ser Gly Pro Ile Arg Ala Tyr Ile Leu Ala His Lys Asp Ala 
65                  70                  75                  80  


Ile Gln Leu Trp Arg Thr Leu Met Gly Pro Thr Arg Val Phe Arg Ala 
                85                  90                  95      


Arg His Val Ala Pro Asp Ser Ile Arg Gly Ser Phe Gly Leu Thr Asp 
            100                 105                 110         


Thr Arg Asn Thr Thr His Gly Ser Asp Ser Val Val Ser Ala Ser Arg 
        115                 120                 125             


Glu Ile Ala Ala Phe Phe Pro Asp Phe Ser Glu Gln Arg Trp Tyr Glu 
    130                 135                 140                 


Glu Glu Glu Pro Gln Leu Arg Cys Gly Pro Val Cys Tyr Ser Pro Glu 
145                 150                 155                 160 


Gly Gly Val His Tyr Val Ala Gly Thr Gly Gly Leu Gly Pro Ala 
                165                 170                 175 


<210>  80
<211>  1306
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding OriGene-NME7-1 full length

<400>  80
gacgttgtat acgactccta tagggcggcc gggaattcgt cgactggatc cggtaccgag       60

gagatctgcc gccgcgatcg ccatgaatca tagtgaaaga ttcgttttca ttgcagagtg      120

gtatgatcca aatgcttcac ttcttcgacg ttatgagctt ttattttacc caggggatgg      180

atctgttgaa atgcatgatg taaagaatca tcgcaccttt ttaaagcgga ccaaatatga      240

taacctgcac ttggaagatt tatttatagg caacaaagtg aatgtcttct ctcgacaact      300

ggtattaatt gactatgggg atcaatatac agctcgccag ctgggcagta ggaaagaaaa      360

aacgctagcc ctaattaaac cagatgcaat atcaaaggct ggagaaataa ttgaaataat      420

aaacaaagct ggatttacta taaccaaact caaaatgatg atgctttcaa ggaaagaagc      480

attggatttt catgtagatc accagtcaag accctttttc aatgagctga tccagtttat      540

tacaactggt cctattattg ccatggagat tttaagagat gatgctatat gtgaatggaa      600

aagactgctg ggacctgcaa actctggagt ggcacgcaca gatgcttctg aaagcattag      660

agccctcttt ggaacagatg gcataagaaa tgcagcgcat ggccctgatt cttttgcttc      720

tgcggccaga gaaatggagt tgttttttcc ttcaagtgga ggttgtgggc cggcaaacac      780

tgctaaattt actaattgta cctgttgcat tgttaaaccc catgctgtca gtgaaggact      840

gttgggaaag atcctgatgg ctatccgaga tgcaggtttt gaaatctcag ctatgcagat      900

gttcaatatg gatcgggtta atgttgagga attctatgaa gtttataaag gagtagtgac      960

cgaatatcat gacatggtga cagaaatgta ttctggccct tgtgtagcaa tggagattca     1020

acagaataat gctacaaaga catttcgaga attttgtgga cctgctgatc ctgaaattgc     1080

ccggcattta cgccctggaa ctctcagagc aatctttggt aaaactaaga tccagaatgc     1140

tgttcactgt actgatctgc cagaggatgg cctattagag gttcaatact tcttcaagat     1200

cttggataat acgcgtacgc ggccgctcga gcagaaactc atctcagaag aggatctggc     1260

agcaaatgat atcctggatt acaaggatga cgacgataag gtttaa                    1306


<210>  81
<211>  407
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OriGene-NME7-1 full length

<400>  81

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn Thr Arg Thr Arg Arg Leu Glu Gln 
    370                 375                 380                 


Lys Leu Ile Ser Glu Glu Asp Leu Ala Ala Asn Asp Ile Leu Asp Tyr 
385                 390                 395                 400 


Lys Asp Asp Asp Asp Lys Val 
                405         


<210>  82
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abnova NME7-1 Full length

<400>  82

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  83
<211>  98
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Abnova Partial NME7-B

<400>  83

Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr Lys Gly Val Val 
1               5                   10                  15      


Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser Gly Pro Cys Val 
            20                  25                  30          


Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr Phe Arg Glu Phe 
        35                  40                  45              


Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu Arg Pro Gly Thr 
    50                  55                  60                  


Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn Ala Val His Cys 
65                  70                  75                  80  


Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln Tyr Phe Phe Lys 
                85                  90                  95      


Ile Leu 
        


<210>  84
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Histidine Tag

<400>  84
ctcgagcacc accaccacca ccactga                                           27


<210>  85
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  DNA encoding Strept II Tag

<400>  85
accggttgga gccatcctca gttcgaaaag taatga                                 36


<210>  86
<211>  32
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  86
atcgatcata tggccaactg tgagcgtacc tt                                     32


<210>  87
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  87
gtggtgctcg agttcataga tccagttctg a                                      31


<210>  88
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  88
gcaggaacat tatacatggc ggtgattctg                                        30


<210>  89
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  89
gccatgtata atgttcctgc caacttgtat                                        30


<210>  90
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  90
tcggggagac caactctgca gactccaag                                         29


<210>  91
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  91
cttggagtct gcagagttgg tctccccga                                         29


<210>  92
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  92
atcgatcata tggccaactg tgagcgtacc ttc                                    33


<210>  93
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  93
gtggtgaccg gtatagatcc agttctgagc aca                                    33


<210>  94
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  94
atcgatcata tggccaactg tgagcgtacc ttc                                    33


<210>  95
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  95
gtggtgaccg gtgatccagt tctgagcaca gct                                    33


<210>  96
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  96
atcgatcata tggccaactg tgagcgtacc ttc                                    33


<210>  97
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  97
gtggtgaccg gtagcacagc tcgtgtaatc tacca                                  35


<210>  98
<211>  51
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  histidine-tagged MUC1* extra cellular domain peptide

<400>  98

Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys 
1               5                   10                  15      


Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val 
            20                  25                  30          


Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala His His His 
        35                  40                  45              


His His His 
    50      


<210>  99
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  99
agagcctcga gattatccag aattttgaaa aagtattg                               38


<210>  100
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  100
atcgatcata tgcatgacgt taaaaatcac                                        30


<210>  101
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  101
agagcctcga gattatccag aattttgaaa aagtattg                               38


<210>  102
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  102
atcgacatat ggaaaaaacg ctggccctga ttaaaccgga tg                          42


<210>  103
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  103
actgcctcga ggaaaaacag ttccatttca cgagctgccg atg                         43


<210>  104
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  104
atcgacatat ggaaaaaacg ctggccctga ttaaaccgga tg                          42


<210>  105
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  105
agagcctcga gattatccag aattttgaaa aagtattg                               38


<210>  106
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  106
atcgacatat ggaaaaaacg ctggccctga ttaaaccgga tg                          42


<210>  107
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  107
agagcaccgg tattatccag aattttgaaa aagtattg                               38


<210>  108
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  108
atcgacatat gacgcaaaat ctgggctcgg aaatg                                  35


<210>  109
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  109
actgcctcga gtgccggacc cagaccaccc gtgc                                   34


<210>  110
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  110
atcgacatat gacgcaaaat ctgggctcgg aaatg                                  35


<210>  111
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  111
actgcaccgg ttgccggacc cagaccaccc gtgcg                                  35


<210>  112
<211>  41
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PSMGFR N-10 peptide

<400>  112

Gln Phe Asn Gln Tyr Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr 
1               5                   10                  15      


Ile Ser Asp Val Ser Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln 
            20                  25                  30          


Ser Gly Ala His His His His His His 
        35                  40      


<210>  113
<211>  376
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  A domain of NME7

<400>  113

Met Asn His Ser Glu Arg Phe Val Phe Ile Ala Glu Trp Tyr Asp Pro 
1               5                   10                  15      


Asn Ala Ser Leu Leu Arg Arg Tyr Glu Leu Leu Phe Tyr Pro Gly Asp 
            20                  25                  30          


Gly Ser Val Glu Met His Asp Val Lys Asn His Arg Thr Phe Leu Lys 
        35                  40                  45              


Arg Thr Lys Tyr Asp Asn Leu His Leu Glu Asp Leu Phe Ile Gly Asn 
    50                  55                  60                  


Lys Val Asn Val Phe Ser Arg Gln Leu Val Leu Ile Asp Tyr Gly Asp 
65                  70                  75                  80  


Gln Tyr Thr Ala Arg Gln Leu Gly Ser Arg Lys Glu Lys Thr Leu Ala 
                85                  90                  95      


Leu Ile Lys Pro Asp Ala Ile Ser Lys Ala Gly Glu Ile Ile Glu Ile 
            100                 105                 110         


Ile Asn Lys Ala Gly Phe Thr Ile Thr Lys Leu Lys Met Met Met Leu 
        115                 120                 125             


Ser Arg Lys Glu Ala Leu Asp Phe His Val Asp His Gln Ser Arg Pro 
    130                 135                 140                 


Phe Phe Asn Glu Leu Ile Gln Phe Ile Thr Thr Gly Pro Ile Ile Ala 
145                 150                 155                 160 


Met Glu Ile Leu Arg Asp Asp Ala Ile Cys Glu Trp Lys Arg Leu Leu 
                165                 170                 175     


Gly Pro Ala Asn Ser Gly Val Ala Arg Thr Asp Ala Ser Glu Ser Ile 
            180                 185                 190         


Arg Ala Leu Phe Gly Thr Asp Gly Ile Arg Asn Ala Ala His Gly Pro 
        195                 200                 205             


Asp Ser Phe Ala Ser Ala Ala Arg Glu Met Glu Leu Phe Phe Pro Ser 
    210                 215                 220                 


Ser Gly Gly Cys Gly Pro Ala Asn Thr Ala Lys Phe Thr Asn Cys Thr 
225                 230                 235                 240 


Cys Cys Ile Val Lys Pro His Ala Val Ser Glu Gly Leu Leu Gly Lys 
                245                 250                 255     


Ile Leu Met Ala Ile Arg Asp Ala Gly Phe Glu Ile Ser Ala Met Gln 
            260                 265                 270         


Met Phe Asn Met Asp Arg Val Asn Val Glu Glu Phe Tyr Glu Val Tyr 
        275                 280                 285             


Lys Gly Val Val Thr Glu Tyr His Asp Met Val Thr Glu Met Tyr Ser 
    290                 295                 300                 


Gly Pro Cys Val Ala Met Glu Ile Gln Gln Asn Asn Ala Thr Lys Thr 
305                 310                 315                 320 


Phe Arg Glu Phe Cys Gly Pro Ala Asp Pro Glu Ile Ala Arg His Leu 
                325                 330                 335     


Arg Pro Gly Thr Leu Arg Ala Ile Phe Gly Lys Thr Lys Ile Gln Asn 
            340                 345                 350         


Ala Val His Cys Thr Asp Leu Pro Glu Asp Gly Leu Leu Glu Val Gln 
        355                 360                 365             


Tyr Phe Phe Lys Ile Leu Asp Asn 
    370                 375     


<210>  114
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  114
atcgacatat gacgcaaaat ctgggctcgg aaatg                                  35


<210>  115
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  115
actgcctcga gtgccggacc cagaccaccc gtgc                                   34


<210>  116
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  116
atcgatcata tgaatcactc cgaacgc                                           27


