                         SEQUENCE LISTING

<110>  Nuclea Biotechnologies, Inc.
 
<120>  Predictive Biomarkers for Breast Cancer

<130>  2015.1006PCT

<140>  PCT/US/2012/xxxxxx
<141>  2012-10-15

<150>  61/605,798
<151>  2012-03-02

<150>  61/547,838
<151>  2012-10-17

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  13
<212>  PRT
<213>  Human


<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  Xaa can be any naturally occurring amino acid

<400>  1

Val Ala Gln Gly Gln Trp Glu Pro Ser Gly Xaa Ala Pro 
1               5                   10              


<210>  2
<211>  13
<212>  PRT
<213>  Human


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  2

Pro Ser Gly Pro Ala Pro Thr Asn Xaa Gly Ala Leu Glu 
1               5                   10              


<210>  3
<211>  13
<212>  PRT
<213>  Human


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Thr Leu Glu Gln Gln His Xaa Val Ala Gln Gly Gln Trp 
1               5                   10              


<210>  4
<211>  17
<212>  PRT
<213>  Human

<400>  4

Glu Val Ala Asp Pro Gly Ser Ala Glu Leu Gln Lys Val Leu Gln Gly 
1               5                   10                  15      


Asp 
    


<210>  5
<211>  14
<212>  PRT
<213>  Human

<400>  5

Glu Leu Ser Ser Lys Ala Asp Glu Ala Ser Glu Leu Ala Cys 
1               5                   10                  


<210>  6
<211>  8481
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (118)..(7653)

<400>  6
gagagacggc agcggccccg gcctccctct ccgccgcgct tcagcctccc gctccgccgc       60

gctccagcct cgctctccgc cgcccgcacc gccgcccgcg ccctcaccag agcagcc         117

atg gag gag gtg gtg att gcc ggc atg tcc ggg aag ctg cca gag tcg        165
Met Glu Glu Val Val Ile Ala Gly Met Ser Gly Lys Leu Pro Glu Ser           
1               5                   10                  15                

gag aac ttg cag gag ttc tgg gac aac ctc atc ggc ggt gtg gac atg        213
Glu Asn Leu Gln Glu Phe Trp Asp Asn Leu Ile Gly Gly Val Asp Met           
            20                  25                  30                    

gtc acg gac gat gac cgt cgc tgg aag gcg ggg ctc tac ggc ctg ccc        261
Val Thr Asp Asp Asp Arg Arg Trp Lys Ala Gly Leu Tyr Gly Leu Pro           
        35                  40                  45                        

cgg cgg tcc ggc aag ctg aag gac ctg tct agg ttt gat gcc tcc ttc        309
Arg Arg Ser Gly Lys Leu Lys Asp Leu Ser Arg Phe Asp Ala Ser Phe           
    50                  55                  60                            

ttc gga gtc cac ccc aag cag gca cac acg atg gac cct cag ctg cgg        357
Phe Gly Val His Pro Lys Gln Ala His Thr Met Asp Pro Gln Leu Arg           
65                  70                  75                  80            

ctg ctg ctg gaa gtc acc tat gaa gcc atc gtg gac gga ggc atc aac        405
Leu Leu Leu Glu Val Thr Tyr Glu Ala Ile Val Asp Gly Gly Ile Asn           
                85                  90                  95                

cca gat tca ctc cga gga aca cac act ggc gtc tgg gtg ggc gtg agc        453
Pro Asp Ser Leu Arg Gly Thr His Thr Gly Val Trp Val Gly Val Ser           
            100                 105                 110                   

ggc tct gag acc tcg gag gcc ctg agc cga gac ccc gag aca ctc gtg        501
Gly Ser Glu Thr Ser Glu Ala Leu Ser Arg Asp Pro Glu Thr Leu Val           
        115                 120                 125                       

ggc tac agc atg gtg ggc tgc cag cga gcg atg atg gcc aac cgg ctc        549
Gly Tyr Ser Met Val Gly Cys Gln Arg Ala Met Met Ala Asn Arg Leu           
    130                 135                 140                           

tcc ttc ttc ttc gac ttc aga ggg ccc agc atc gca ctg gac aca gcc        597
Ser Phe Phe Phe Asp Phe Arg Gly Pro Ser Ile Ala Leu Asp Thr Ala           
145                 150                 155                 160           

tgc tcc tcc agc ctg atg gcc ctg cag aac gcc tac cag gcc atc cac        645
Cys Ser Ser Ser Leu Met Ala Leu Gln Asn Ala Tyr Gln Ala Ile His           
                165                 170                 175               

agc ggg cag tgc cct gcc gcc atc gtg ggg ggc atc aat gtc ctg ctg        693
Ser Gly Gln Cys Pro Ala Ala Ile Val Gly Gly Ile Asn Val Leu Leu           
            180                 185                 190                   

aag ccc aac acc tcc gtg cag ttc ttg agg ctg ggg atg ctc agc ccc        741
Lys Pro Asn Thr Ser Val Gln Phe Leu Arg Leu Gly Met Leu Ser Pro           
        195                 200                 205                       

gag ggc acc tgc aag gcc ttc gac aca gcg ggg aat ggg tac tgc cgc        789
Glu Gly Thr Cys Lys Ala Phe Asp Thr Ala Gly Asn Gly Tyr Cys Arg           
    210                 215                 220                           

tcg gag ggt gtg gtg gcc gtc ctg ctg acc aag aag tcc ctg gcc cgg        837
Ser Glu Gly Val Val Ala Val Leu Leu Thr Lys Lys Ser Leu Ala Arg           
225                 230                 235                 240           

cgg gtg tac gcc acc atc ctg aac gcc ggc acc aat aca gat ggc ttc        885
Arg Val Tyr Ala Thr Ile Leu Asn Ala Gly Thr Asn Thr Asp Gly Phe           
                245                 250                 255               

aag gag caa ggc gtg acc ttc ccc tca ggg gat atc cag gag cag ctc        933
Lys Glu Gln Gly Val Thr Phe Pro Ser Gly Asp Ile Gln Glu Gln Leu           
            260                 265                 270                   

atc cgc tcg ttg tac cag tcg gcc gga gtg gcc cct gag tca ttt gaa        981
Ile Arg Ser Leu Tyr Gln Ser Ala Gly Val Ala Pro Glu Ser Phe Glu           
        275                 280                 285                       

tac atc gaa gcc cac ggc aca ggc acc aag gtg ggc gac ccc cag gag       1029
Tyr Ile Glu Ala His Gly Thr Gly Thr Lys Val Gly Asp Pro Gln Glu           
    290                 295                 300                           

ctg aat ggc atc acc cga gcc ctg tgc gcc acc cgc cag gag ccg ctg       1077
Leu Asn Gly Ile Thr Arg Ala Leu Cys Ala Thr Arg Gln Glu Pro Leu           
305                 310                 315                 320           

ctc atc ggc tcc acc aag tcc aac atg ggg cac ccg gag cca gcc tcg       1125
Leu Ile Gly Ser Thr Lys Ser Asn Met Gly His Pro Glu Pro Ala Ser           
                325                 330                 335               

ggg ctg gca gcc ctg gcc aag gtg ctg ctg tcc ctg gag cac ggg ctc       1173
Gly Leu Ala Ala Leu Ala Lys Val Leu Leu Ser Leu Glu His Gly Leu           
            340                 345                 350                   

tgg gcc ccc aac ctg cac ttc cat agc ccc aac cct gag atc cca gcg       1221
Trp Ala Pro Asn Leu His Phe His Ser Pro Asn Pro Glu Ile Pro Ala           
        355                 360                 365                       

ctg ttg gat ggg cgg ctg cag gtg gtg gac cag ccc ctg ccc gtc cgt       1269
Leu Leu Asp Gly Arg Leu Gln Val Val Asp Gln Pro Leu Pro Val Arg           
    370                 375                 380                           

ggc ggc aac gtg ggc atc aac tcc ttt ggc ttc ggg ggc tcc aac gtg       1317
Gly Gly Asn Val Gly Ile Asn Ser Phe Gly Phe Gly Gly Ser Asn Val           
385                 390                 395                 400           

cac atc atc ctg agg ccc aac acg cag ccg ccc ccc gca ccc gcc cca       1365
His Ile Ile Leu Arg Pro Asn Thr Gln Pro Pro Pro Ala Pro Ala Pro           
                405                 410                 415               

cat gcc acc ctg ccc cgt ctg ctg cgg gcc agc gga cgc acc cct gag       1413
His Ala Thr Leu Pro Arg Leu Leu Arg Ala Ser Gly Arg Thr Pro Glu           
            420                 425                 430                   

gcc gtg cag aag ctg ctg gag cag ggc ctc cgg cac agc cag gac ctg       1461
Ala Val Gln Lys Leu Leu Glu Gln Gly Leu Arg His Ser Gln Asp Leu           
        435                 440                 445                       

gct ttc ctg agc atg ctg aac gac atc gcg gct gtc ccc gcc acc gcc       1509
Ala Phe Leu Ser Met Leu Asn Asp Ile Ala Ala Val Pro Ala Thr Ala           
    450                 455                 460                           

atg ccc ttc cgt ggc tac gct gtg ctg ggt ggt gag cgc ggt ggc cca       1557
Met Pro Phe Arg Gly Tyr Ala Val Leu Gly Gly Glu Arg Gly Gly Pro           
465                 470                 475                 480           

gag gtg cag cag gtg ccc gct ggc gag cgc ccg ctc tgg ttc atc tgc       1605
Glu Val Gln Gln Val Pro Ala Gly Glu Arg Pro Leu Trp Phe Ile Cys           
                485                 490                 495               

tct ggg atg ggc aca cag tgg cgc ggg atg ggg ctg agc ctc atg cgc       1653
Ser Gly Met Gly Thr Gln Trp Arg Gly Met Gly Leu Ser Leu Met Arg           
            500                 505                 510                   

ctg gac cgc ttc cga gat tcc atc cta cgc tcc gat gag gct gtg aag       1701
Leu Asp Arg Phe Arg Asp Ser Ile Leu Arg Ser Asp Glu Ala Val Lys           
        515                 520                 525                       

cca ttc ggc ctg aag gtg tca cag ctg ctg ctg agc aca gac gag agc       1749
Pro Phe Gly Leu Lys Val Ser Gln Leu Leu Leu Ser Thr Asp Glu Ser           
    530                 535                 540                           

acc ttt gat gac atc gtc cat tcg ttt gtg agc ctg act gcc atc cag       1797
Thr Phe Asp Asp Ile Val His Ser Phe Val Ser Leu Thr Ala Ile Gln           
545                 550                 555                 560           

ata ggc ctc ata gac ctg ctg agc tgc atg ggg ctg agg cca gat ggc       1845
Ile Gly Leu Ile Asp Leu Leu Ser Cys Met Gly Leu Arg Pro Asp Gly           
                565                 570                 575               

atc gtc ggc cac tcc ctg ggg gag gtg gcc tgt ggc tac gcc gac ggc       1893
Ile Val Gly His Ser Leu Gly Glu Val Ala Cys Gly Tyr Ala Asp Gly           
            580                 585                 590                   

tgc ctg tcc cag gag gag gcc gtc ctc gct gcc tac tgg agg gga cag       1941
Cys Leu Ser Gln Glu Glu Ala Val Leu Ala Ala Tyr Trp Arg Gly Gln           
        595                 600                 605                       

tgc atc aaa gaa gcc cat ctc ccg ccg ggc gcc atg gca gcc gtg ggc       1989
Cys Ile Lys Glu Ala His Leu Pro Pro Gly Ala Met Ala Ala Val Gly           
    610                 615                 620                           

ttg tcc tgg gag gag tgt aaa cag cgc tgc ccc ccg ggc gtg gtg ccc       2037
Leu Ser Trp Glu Glu Cys Lys Gln Arg Cys Pro Pro Gly Val Val Pro           
625                 630                 635                 640           

gcc tgc cac aac tcc aag gac aca gtc acc atc tcg gga cct cag gcc       2085
Ala Cys His Asn Ser Lys Asp Thr Val Thr Ile Ser Gly Pro Gln Ala           
                645                 650                 655               

ccg gtg ttt gag ttc gtg gag cag ctg agg aag gag ggt gtg ttt gcc       2133
Pro Val Phe Glu Phe Val Glu Gln Leu Arg Lys Glu Gly Val Phe Ala           
            660                 665                 670                   

aag gag gtg cgg acc ggc ggt atg gcc ttc cac tcc tac ttc atg gag       2181
Lys Glu Val Arg Thr Gly Gly Met Ala Phe His Ser Tyr Phe Met Glu           
        675                 680                 685                       

gcc atc gca ccc cca ctg ctg cag gag ctc aag aag gtg atc cgg gag       2229
Ala Ile Ala Pro Pro Leu Leu Gln Glu Leu Lys Lys Val Ile Arg Glu           
    690                 695                 700                           

ccg aag cca cgt tca gcc cgc tgg ctc agc acc tct atc ccc gag gcc       2277
Pro Lys Pro Arg Ser Ala Arg Trp Leu Ser Thr Ser Ile Pro Glu Ala           
705                 710                 715                 720           

cag tgg cac agc agc ctg gca cgc acg tcc tcc gcc gag tac aat gtc       2325
Gln Trp His Ser Ser Leu Ala Arg Thr Ser Ser Ala Glu Tyr Asn Val           
                725                 730                 735               

aac aac ctg gtg agc cct gtg ctg ttc cag gag gcc ctg tgg cac gtg       2373
Asn Asn Leu Val Ser Pro Val Leu Phe Gln Glu Ala Leu Trp His Val           
            740                 745                 750                   

cct gag cac gcg gtg gtg ctg gag atc gcg ccc cac gcc ctg ctg cag       2421
Pro Glu His Ala Val Val Leu Glu Ile Ala Pro His Ala Leu Leu Gln           
        755                 760                 765                       

gct gtc ctg aag cgt ggc ctg aag ccg agc tgc acc atc atc ccc ctg       2469
Ala Val Leu Lys Arg Gly Leu Lys Pro Ser Cys Thr Ile Ile Pro Leu           
    770                 775                 780                           

atg aag aag gat cac agg gac aac ctg gag ttc ttc ctg gcc ggc atc       2517
Met Lys Lys Asp His Arg Asp Asn Leu Glu Phe Phe Leu Ala Gly Ile           
785                 790                 795                 800           

ggc agg ctg cac ctc tca ggc atc gac gcc aac ccc aat gcc ttg ttc       2565
Gly Arg Leu His Leu Ser Gly Ile Asp Ala Asn Pro Asn Ala Leu Phe           
                805                 810                 815               

cca cct gtg gag ttc cca gct ccc cga gga act ccc ctc atc tcc cca       2613
Pro Pro Val Glu Phe Pro Ala Pro Arg Gly Thr Pro Leu Ile Ser Pro           
            820                 825                 830                   

ctc atc aag tgg gac cac agc ctg gcc tgg gac gtg ccg gcc gcc gag       2661
Leu Ile Lys Trp Asp His Ser Leu Ala Trp Asp Val Pro Ala Ala Glu           
        835                 840                 845                       

gac ttc ccc aac ggt tca ggt tcc ccc tca gcc gcc atc tac aac atc       2709
Asp Phe Pro Asn Gly Ser Gly Ser Pro Ser Ala Ala Ile Tyr Asn Ile           
    850                 855                 860                           

gac acc agc tcc gag tct cct gac cac tac ctg gtg gac cac acc ctc       2757
Asp Thr Ser Ser Glu Ser Pro Asp His Tyr Leu Val Asp His Thr Leu           
865                 870                 875                 880           

gac ggt cgc gtc ctc ttc ccc gcc act ggc tac ctg agc ata gtg tgg       2805
Asp Gly Arg Val Leu Phe Pro Ala Thr Gly Tyr Leu Ser Ile Val Trp           
                885                 890                 895               

aag acg ctg gcc cgc gcc ctg ggc ctg ggc gtc gag cag ctg cct gtg       2853
Lys Thr Leu Ala Arg Ala Leu Gly Leu Gly Val Glu Gln Leu Pro Val           
            900                 905                 910                   

gtg ttt gag gat gtg gtg ctg cac cag gcc acc atc ctg ccc aag act       2901
Val Phe Glu Asp Val Val Leu His Gln Ala Thr Ile Leu Pro Lys Thr           
        915                 920                 925                       

ggg aca gtg tcc ctg gag gta cgg ctc ctg gag gcc tcc cgt gcc ttc       2949
Gly Thr Val Ser Leu Glu Val Arg Leu Leu Glu Ala Ser Arg Ala Phe           
    930                 935                 940                           

gag gtg tca gag aac ggc aac ctg gta gtg agt ggg aag gtg tac cag       2997
Glu Val Ser Glu Asn Gly Asn Leu Val Val Ser Gly Lys Val Tyr Gln           
945                 950                 955                 960           

tgg gat gac cct gac ccc agg ctc ttc gac cac ccg gaa agc ccc acc       3045
Trp Asp Asp Pro Asp Pro Arg Leu Phe Asp His Pro Glu Ser Pro Thr           
                965                 970                 975               

ccc aac ccc acg gag ccc ctc ttc ctg gcc cag gct gaa gtt tac aag       3093
Pro Asn Pro Thr Glu Pro Leu Phe Leu Ala Gln Ala Glu Val Tyr Lys           
            980                 985                 990                   

gag ctg cgt ctg cgt ggc tac gac  tac ggc cct cat ttc  cag ggc atc     3141
Glu Leu Arg Leu Arg Gly Tyr Asp  Tyr Gly Pro His Phe  Gln Gly Ile         
        995                 1000                 1005                     

ctg gag  gcc agc ctg gaa ggt  gac tcg ggg agg ctg  ctg tgg aag        3186
Leu Glu  Ala Ser Leu Glu Gly  Asp Ser Gly Arg Leu  Leu Trp Lys            
    1010                 1015                 1020                        

gat aac  tgg gtg agc ttc atg  gac acc atg ctg cag  atg tcc atc        3231
Asp Asn  Trp Val Ser Phe Met  Asp Thr Met Leu Gln  Met Ser Ile            
    1025                 1030                 1035                        

ctg ggc  tcg gcc aag cac ggc  ctg tac ctg ccc acc  cgt gtc acc        3276
Leu Gly  Ser Ala Lys His Gly  Leu Tyr Leu Pro Thr  Arg Val Thr            
    1040                 1045                 1050                        

gcc atc  cac atc gac cct gcc  acc cac agg cag aag  ctg tac aca        3321
Ala Ile  His Ile Asp Pro Ala  Thr His Arg Gln Lys  Leu Tyr Thr            
    1055                 1060                 1065                        

ctg cag  gac aag gcc caa gtg  gct gac gtg gtg gtg  agc agg tgg        3366
Leu Gln  Asp Lys Ala Gln Val  Ala Asp Val Val Val  Ser Arg Trp            
    1070                 1075                 1080                        

ctg agg  gtc aca gtg gcc gga  ggc gtc cac atc tcc  ggg ctc cac        3411
Leu Arg  Val Thr Val Ala Gly  Gly Val His Ile Ser  Gly Leu His            
    1085                 1090                 1095                        

act gag  tcg gcc ccg cgg cgg  cag cag gag cag cag  gtg ccc atc        3456
Thr Glu  Ser Ala Pro Arg Arg  Gln Gln Glu Gln Gln  Val Pro Ile            
    1100                 1105                 1110                        

ctg gag  aag ttt tgc ttc act  ccc cac acg gag gag  ggg tgc ctg        3501
Leu Glu  Lys Phe Cys Phe Thr  Pro His Thr Glu Glu  Gly Cys Leu            
    1115                 1120                 1125                        

tct gag  cgc gct gcc ctg cag  gag gag ctg caa ctg  tgc aag ggg        3546
Ser Glu  Arg Ala Ala Leu Gln  Glu Glu Leu Gln Leu  Cys Lys Gly            
    1130                 1135                 1140                        

ctg gtg  cag gca ctg cag acc  aag gtg acc cag cag  ggg ctg aag        3591
Leu Val  Gln Ala Leu Gln Thr  Lys Val Thr Gln Gln  Gly Leu Lys            
    1145                 1150                 1155                        

atg gtg  gtg ccc gga ctg gat  ggg gcc cag atc ccc  cgg gac ccc        3636
Met Val  Val Pro Gly Leu Asp  Gly Ala Gln Ile Pro  Arg Asp Pro            
    1160                 1165                 1170                        

tca cag  cag gaa ctg ccc cgg  ctg ttg tcg gct gcc  tgc agg ctt        3681
Ser Gln  Gln Glu Leu Pro Arg  Leu Leu Ser Ala Ala  Cys Arg Leu            
    1175                 1180                 1185                        

cag ctc  aac ggg aac ctg cag  ctg gag ctg gcg cag  gtg ctg gcc        3726
Gln Leu  Asn Gly Asn Leu Gln  Leu Glu Leu Ala Gln  Val Leu Ala            
    1190                 1195                 1200                        

cag gag  agg ccc aag ctg cca  gag gac cct ctg ctc  agc ggc ctc        3771
Gln Glu  Arg Pro Lys Leu Pro  Glu Asp Pro Leu Leu  Ser Gly Leu            
    1205                 1210                 1215                        

ctg gac  tcc ccg gca ctc aag  gcc tgc ctg gac act  gcc gtg gag        3816
Leu Asp  Ser Pro Ala Leu Lys  Ala Cys Leu Asp Thr  Ala Val Glu            
    1220                 1225                 1230                        

aac atg  ccc agc ctg aag atg  aag gtg gtg gag gtg  ctg gct ggc        3861
Asn Met  Pro Ser Leu Lys Met  Lys Val Val Glu Val  Leu Ala Gly            
    1235                 1240                 1245                        

cac ggt  cac ctg tat tcc cgc  atc cca ggc ctg ctc  agc ccc cat        3906
His Gly  His Leu Tyr Ser Arg  Ile Pro Gly Leu Leu  Ser Pro His            
    1250                 1255                 1260                        

ccc ctg  ctg cag ctg agc tac  acg gcc acc gac cgc  cac ccc cag        3951
Pro Leu  Leu Gln Leu Ser Tyr  Thr Ala Thr Asp Arg  His Pro Gln            
    1265                 1270                 1275                        

gcc ctg  gag gct gcc cag gcc  gag ctg cag cag cac  gac gtt gcc        3996
Ala Leu  Glu Ala Ala Gln Ala  Glu Leu Gln Gln His  Asp Val Ala            
    1280                 1285                 1290                        

cag ggc  cag tgg gat ccc gca  gac cct gcc ccc agc  gcc ctg ggc        4041
Gln Gly  Gln Trp Asp Pro Ala  Asp Pro Ala Pro Ser  Ala Leu Gly            
    1295                 1300                 1305                        

agc gcc  gac ctc ctg gtg tgc  aac tgt gct gtg gct  gcc ctc ggg        4086
Ser Ala  Asp Leu Leu Val Cys  Asn Cys Ala Val Ala  Ala Leu Gly            
    1310                 1315                 1320                        

gac ccg  gcc tca gct ctc agc  aac atg gtg gct gcc  ctg aga gaa        4131
Asp Pro  Ala Ser Ala Leu Ser  Asn Met Val Ala Ala  Leu Arg Glu            
    1325                 1330                 1335                        

ggg ggc  ttt ctg ctc ctg cac  aca ctg ctc cgg ggg  cac ccc ctc        4176
Gly Gly  Phe Leu Leu Leu His  Thr Leu Leu Arg Gly  His Pro Leu            
    1340                 1345                 1350                        

ggg gac  atc gtg gcc ttc ctc  acc tcc act gag ccg  cag tat ggc        4221
Gly Asp  Ile Val Ala Phe Leu  Thr Ser Thr Glu Pro  Gln Tyr Gly            
    1355                 1360                 1365                        

cag ggc  atc ctg agc cag gac  gcg tgg gag agc ctc  ttc tcc agg        4266
Gln Gly  Ile Leu Ser Gln Asp  Ala Trp Glu Ser Leu  Phe Ser Arg            
    1370                 1375                 1380                        

gtg tcg  ctg cgc ctg gtg ggc  ctg aag aag tcc ttc  tac ggc tcc        4311
Val Ser  Leu Arg Leu Val Gly  Leu Lys Lys Ser Phe  Tyr Gly Ser            
    1385                 1390                 1395                        

acg ctc  ttc ctg tgc cgc cgg  ccc acc ccg cag gac  agc ccc atc        4356
Thr Leu  Phe Leu Cys Arg Arg  Pro Thr Pro Gln Asp  Ser Pro Ile            
    1400                 1405                 1410                        

ttc ctg  ccg gtg gac gat acc  agc ttc cgc tgg gtg  gag tct ctg        4401
Phe Leu  Pro Val Asp Asp Thr  Ser Phe Arg Trp Val  Glu Ser Leu            
    1415                 1420                 1425                        

aag ggc  atc ctg gct gac gaa  gac tct tcc cgg cct  gtg tgg ctg        4446
Lys Gly  Ile Leu Ala Asp Glu  Asp Ser Ser Arg Pro  Val Trp Leu            
    1430                 1435                 1440                        

aag gcc  atc aac tgt gcc acc  tcg ggc gtg gtg ggc  ttg gtg aac        4491
Lys Ala  Ile Asn Cys Ala Thr  Ser Gly Val Val Gly  Leu Val Asn            
    1445                 1450                 1455                        

tgt ctc  cgc cga gag ccc ggc  ggg aac cgc ctc cgg  tgt gtg ctg        4536
Cys Leu  Arg Arg Glu Pro Gly  Gly Asn Arg Leu Arg  Cys Val Leu            
    1460                 1465                 1470                        

ctc tcc  aac ctc agc agc acc  tcc cac gtc ccg gag  gtg gac ccg        4581
Leu Ser  Asn Leu Ser Ser Thr  Ser His Val Pro Glu  Val Asp Pro            
    1475                 1480                 1485                        

ggc tcc  gca gaa ctg cag aag  gtg ttg cag gga gac  ctg gtg atg        4626
Gly Ser  Ala Glu Leu Gln Lys  Val Leu Gln Gly Asp  Leu Val Met            
    1490                 1495                 1500                        

aac gtc  tac cgc gac ggg gcc  tgg ggg gct ttc cgc  cac ttc ctg        4671
Asn Val  Tyr Arg Asp Gly Ala  Trp Gly Ala Phe Arg  His Phe Leu            
    1505                 1510                 1515                        

ctg gag  gag gac aag cct gag  gag ccg acg gca cat  gcc ttt gtg        4716
Leu Glu  Glu Asp Lys Pro Glu  Glu Pro Thr Ala His  Ala Phe Val            
    1520                 1525                 1530                        

agc acc  ctc acc cgg ggg gac  ctg tcc tcc atc cgc  tgg gtc tgc        4761
Ser Thr  Leu Thr Arg Gly Asp  Leu Ser Ser Ile Arg  Trp Val Cys            
    1535                 1540                 1545                        

tcc tcg  ctg cgc cat gcc cag  ccc acc tgc cct ggc  gcc cag ctc        4806
Ser Ser  Leu Arg His Ala Gln  Pro Thr Cys Pro Gly  Ala Gln Leu            
    1550                 1555                 1560                        

tgc acg  gtc tac tac gcc tcc  ctc aac ttc cgc gac  atc atg ctg        4851
Cys Thr  Val Tyr Tyr Ala Ser  Leu Asn Phe Arg Asp  Ile Met Leu            
    1565                 1570                 1575                        

gcc act  ggc aag ctg tcc cct  gat gcc atc cca ggg  aag tgg acc        4896
Ala Thr  Gly Lys Leu Ser Pro  Asp Ala Ile Pro Gly  Lys Trp Thr            
    1580                 1585                 1590                        

tcc cag  gac agc ctg cta ggt  atg gag ttc tcg ggc  cga gac gcc        4941
Ser Gln  Asp Ser Leu Leu Gly  Met Glu Phe Ser Gly  Arg Asp Ala            
    1595                 1600                 1605                        

agc ggc  aag cgt gtg atg gga  ctg gtg cct gcc aag  ggc ctg gcc        4986
Ser Gly  Lys Arg Val Met Gly  Leu Val Pro Ala Lys  Gly Leu Ala            
    1610                 1615                 1620                        

acc tct  gtc ctg ctg tca ccg  gac ttc ctc tgg gat  gtg cct tcc        5031
Thr Ser  Val Leu Leu Ser Pro  Asp Phe Leu Trp Asp  Val Pro Ser            
    1625                 1630                 1635                        

aac tgg  acg ctg gag gag gcg  gcc tcg gtg cct gtc  gtc tac agc        5076
Asn Trp  Thr Leu Glu Glu Ala  Ala Ser Val Pro Val  Val Tyr Ser            
    1640                 1645                 1650                        

acg gcc  tac tac gcg ctg gtg  gtg cgt ggg cgg gtg  cgc ccc ggg        5121
Thr Ala  Tyr Tyr Ala Leu Val  Val Arg Gly Arg Val  Arg Pro Gly            
    1655                 1660                 1665                        

gag acg  ctg ctc atc cac tcg  ggc tcg ggc ggc gtg  ggc cag gcc        5166
Glu Thr  Leu Leu Ile His Ser  Gly Ser Gly Gly Val  Gly Gln Ala            
    1670                 1675                 1680                        

gcc atc  gcc atc gcc ctc agt  ctg ggc tgc cgc gtc  ttc acc acc        5211
Ala Ile  Ala Ile Ala Leu Ser  Leu Gly Cys Arg Val  Phe Thr Thr            
    1685                 1690                 1695                        

gtg ggg  tcg gct gag aag cgg  gcg tac ctc cag gcc  agg ttc ccc        5256
Val Gly  Ser Ala Glu Lys Arg  Ala Tyr Leu Gln Ala  Arg Phe Pro            
    1700                 1705                 1710                        

cag ctc  gac agc acc agc ttc  gcc aac tcc cgg gac  aca tcc ttc        5301
Gln Leu  Asp Ser Thr Ser Phe  Ala Asn Ser Arg Asp  Thr Ser Phe            
    1715                 1720                 1725                        

gag cag  cat gtg ctg tgg cac  acg ggc ggg aag ggc  gtt gac ctg        5346
Glu Gln  His Val Leu Trp His  Thr Gly Gly Lys Gly  Val Asp Leu            
    1730                 1735                 1740                        

gtc ttg  aac tcc ttg gcg gaa  gag aag ctg cag gcc  agc gtg agg        5391
Val Leu  Asn Ser Leu Ala Glu  Glu Lys Leu Gln Ala  Ser Val Arg            
    1745                 1750                 1755                        

tgc ttg  gct acg cac ggt cgc  ttc ctg gaa att ggc  aaa ttc gac        5436
Cys Leu  Ala Thr His Gly Arg  Phe Leu Glu Ile Gly  Lys Phe Asp            
    1760                 1765                 1770                        

ctt tct  cag aac cac ccg ctc  ggc atg gct atc ttc  ctg aag aac        5481
Leu Ser  Gln Asn His Pro Leu  Gly Met Ala Ile Phe  Leu Lys Asn            
    1775                 1780                 1785                        

gtg aca  ttc cac ggg gtc cta  ctg gat gcg ttc ttc  aac gag agc        5526
Val Thr  Phe His Gly Val Leu  Leu Asp Ala Phe Phe  Asn Glu Ser            
    1790                 1795                 1800                        

agt gct  gac tgg cgg gag gtg  tgg gcg ctt gtg cag  gcc ggc atc        5571
Ser Ala  Asp Trp Arg Glu Val  Trp Ala Leu Val Gln  Ala Gly Ile            
    1805                 1810                 1815                        

cgg gat  ggg gtg gta cgg ccc  ctc aag tgc acg gtg  ttc cat ggg        5616
Arg Asp  Gly Val Val Arg Pro  Leu Lys Cys Thr Val  Phe His Gly            
    1820                 1825                 1830                        

gcc cag  gtg gag gac gcc ttc  cgc tac atg gcc caa  ggg aag cac        5661
Ala Gln  Val Glu Asp Ala Phe  Arg Tyr Met Ala Gln  Gly Lys His            
    1835                 1840                 1845                        

att ggc  aaa gtc gtc gtg cag  gtg ctt gcg gag gag  ccg gag gca        5706
Ile Gly  Lys Val Val Val Gln  Val Leu Ala Glu Glu  Pro Glu Ala            
    1850                 1855                 1860                        

gtg ctg  aag ggg gcc aaa ccc  aag ctg atg tcg gcc  atc tcc aag        5751
Val Leu  Lys Gly Ala Lys Pro  Lys Leu Met Ser Ala  Ile Ser Lys            
    1865                 1870                 1875                        

acc ttc  tgc ccg gcc cac aag  agc tac atc atc gct  ggt ggt ctg        5796
Thr Phe  Cys Pro Ala His Lys  Ser Tyr Ile Ile Ala  Gly Gly Leu            
    1880                 1885                 1890                        

ggt ggc  ttc ggc ctg gag ttg  gcg cag tgg ctg ata  cag cgt ggg        5841
Gly Gly  Phe Gly Leu Glu Leu  Ala Gln Trp Leu Ile  Gln Arg Gly            
    1895                 1900                 1905                        

gtg cag  aag ctc gtg ttg act  tct cgc tcc ggg atc  cgg aca ggc        5886
Val Gln  Lys Leu Val Leu Thr  Ser Arg Ser Gly Ile  Arg Thr Gly            
    1910                 1915                 1920                        

tac cag  gcc aag cag gtc cgc  cgg tgg agg cgc cag  ggc gta cag        5931
Tyr Gln  Ala Lys Gln Val Arg  Arg Trp Arg Arg Gln  Gly Val Gln            
    1925                 1930                 1935                        

gtg cag  gtg tcc acc agc aac  atc agc tca ctg gag  ggg gcc cgg        5976
Val Gln  Val Ser Thr Ser Asn  Ile Ser Ser Leu Glu  Gly Ala Arg            
    1940                 1945                 1950                        

ggc ctc  att gcc gag gcg gcg  cag ctt ggg ccc gtg  ggc ggc gtc        6021
Gly Leu  Ile Ala Glu Ala Ala  Gln Leu Gly Pro Val  Gly Gly Val            
    1955                 1960                 1965                        

ttc aac  ctg gcc gtg gtc ttg  aga gat ggc ttg ctg  gag aac cag        6066
Phe Asn  Leu Ala Val Val Leu  Arg Asp Gly Leu Leu  Glu Asn Gln            
    1970                 1975                 1980                        

acc cca  gag ttc ttc cag gac  gtc tgc aag ccc aag  tac agc ggc        6111
Thr Pro  Glu Phe Phe Gln Asp  Val Cys Lys Pro Lys  Tyr Ser Gly            
    1985                 1990                 1995                        

acc ctg  aac ctg gac agg gtg  acc cga gag gcg tgc  cct gag ctg        6156
Thr Leu  Asn Leu Asp Arg Val  Thr Arg Glu Ala Cys  Pro Glu Leu            
    2000                 2005                 2010                        

gac tac  ttt gtg gtc ttc tcc  tct gtg agc tgc ggg  cgt ggc aat        6201
Asp Tyr  Phe Val Val Phe Ser  Ser Val Ser Cys Gly  Arg Gly Asn            
    2015                 2020                 2025                        

gcg gga  cag agc aac tac ggc  ttt gcc aat tcc gcc  atg gag cgt        6246
Ala Gly  Gln Ser Asn Tyr Gly  Phe Ala Asn Ser Ala  Met Glu Arg            
    2030                 2035                 2040                        

atc tgt  gag aaa cgc cgg cac  gaa ggc ctc cca ggc  ctg gcc gtg        6291
Ile Cys  Glu Lys Arg Arg His  Glu Gly Leu Pro Gly  Leu Ala Val            
    2045                 2050                 2055                        

cag tgg  ggc gcc atc ggc gac  gtg ggc att ttg gtg  gag acg atg        6336
Gln Trp  Gly Ala Ile Gly Asp  Val Gly Ile Leu Val  Glu Thr Met            
    2060                 2065                 2070                        

agc acc  aac gac acg atc gtc  agt ggc acg ctg ccc  cag cgc atg        6381
Ser Thr  Asn Asp Thr Ile Val  Ser Gly Thr Leu Pro  Gln Arg Met            
    2075                 2080                 2085                        

gcg tcc  tgc ctg gag gtg ctg  gac ctc ttc ctg aac  cag ccc cac        6426
Ala Ser  Cys Leu Glu Val Leu  Asp Leu Phe Leu Asn  Gln Pro His            
    2090                 2095                 2100                        

atg gtc  ctg agc agc ttt gtg  ctg gct gag aag gct  gcg gcc tat        6471
Met Val  Leu Ser Ser Phe Val  Leu Ala Glu Lys Ala  Ala Ala Tyr            
    2105                 2110                 2115                        

agg gac  agg gac agc cag cgg  gac ctg gtg gag gcc  gtg gca cac        6516
Arg Asp  Arg Asp Ser Gln Arg  Asp Leu Val Glu Ala  Val Ala His            
    2120                 2125                 2130                        

atc ctg  ggc atc cgc gac ttg  gct gct gtc aac ctg  gac agc tca        6561
Ile Leu  Gly Ile Arg Asp Leu  Ala Ala Val Asn Leu  Asp Ser Ser            
    2135                 2140                 2145                        

ctg gcg  gac ctg ggc ctg gac  tcg ctc atg agc gtg  gag gtg cgc        6606
Leu Ala  Asp Leu Gly Leu Asp  Ser Leu Met Ser Val  Glu Val Arg            
    2150                 2155                 2160                        

cag acg  ctg gag cgt gag ctc  aac ctg gtg ctg tcc  gtg cgc gag        6651
Gln Thr  Leu Glu Arg Glu Leu  Asn Leu Val Leu Ser  Val Arg Glu            
    2165                 2170                 2175                        

gtg cgg  caa ctc acg ctc cgg  aaa ctg cag gag ctg  tcc tca aag        6696
Val Arg  Gln Leu Thr Leu Arg  Lys Leu Gln Glu Leu  Ser Ser Lys            
    2180                 2185                 2190                        

gcg gat  gag gcc agc gag ctg  gca tgc ccc acg ccc  aag gag gat        6741
Ala Asp  Glu Ala Ser Glu Leu  Ala Cys Pro Thr Pro  Lys Glu Asp            
    2195                 2200                 2205                        

ggt ctg  gcc cag cag cag act  cag ctg aac ctg cgc  tcc ctg ctg        6786
Gly Leu  Ala Gln Gln Gln Thr  Gln Leu Asn Leu Arg  Ser Leu Leu            
    2210                 2215                 2220                        

gtg aac  ccg gag ggc ccc acc  ctg atg cgg ctc aac  tcc gtg cag        6831
Val Asn  Pro Glu Gly Pro Thr  Leu Met Arg Leu Asn  Ser Val Gln            
    2225                 2230                 2235                        

agc tcg  gag cgg ccc ctg ttc  ctg gtg cac cca atc  gag ggc tcc        6876
Ser Ser  Glu Arg Pro Leu Phe  Leu Val His Pro Ile  Glu Gly Ser            
    2240                 2245                 2250                        

acc acc  gtg ttc cac agc ctg  gcc tcc cgg ctc agc  atc ccc acc        6921
Thr Thr  Val Phe His Ser Leu  Ala Ser Arg Leu Ser  Ile Pro Thr            
    2255                 2260                 2265                        

tat ggc  ctg cag tgc acc cga  gct gcg ccc ctt gac  agc atc cac        6966
Tyr Gly  Leu Gln Cys Thr Arg  Ala Ala Pro Leu Asp  Ser Ile His            
    2270                 2275                 2280                        

agc ctg  gct gcc tac tac atc  gac tgc atc agg cag  gtg cag ccc        7011
Ser Leu  Ala Ala Tyr Tyr Ile  Asp Cys Ile Arg Gln  Val Gln Pro            
    2285                 2290                 2295                        

gag ggc  ccc tac cgc gtg gcc  ggc tac tcc tac ggg  gcc tgc gtg        7056
Glu Gly  Pro Tyr Arg Val Ala  Gly Tyr Ser Tyr Gly  Ala Cys Val            
    2300                 2305                 2310                        

gcc ttt  gaa atg tgc tcc cag  ctg cag gcc cag cag  agc cca gcc        7101
Ala Phe  Glu Met Cys Ser Gln  Leu Gln Ala Gln Gln  Ser Pro Ala            
    2315                 2320                 2325                        

ccc acc  cac aac agc ctc ttc  ctg ttc gac ggc tcg  ccc acc tac        7146
Pro Thr  His Asn Ser Leu Phe  Leu Phe Asp Gly Ser  Pro Thr Tyr            
    2330                 2335                 2340                        

gta ctg  gcc tac acc cag agc  tac cgg gca aag ctg  acc cca ggc        7191
Val Leu  Ala Tyr Thr Gln Ser  Tyr Arg Ala Lys Leu  Thr Pro Gly            
    2345                 2350                 2355                        

tgt gag  gct gag gct gag acg  gag gcc ata tgc ttc  ttc gtg cag        7236
Cys Glu  Ala Glu Ala Glu Thr  Glu Ala Ile Cys Phe  Phe Val Gln            
    2360                 2365                 2370                        

cag ttc  acg gac atg gag cac  aac agg gtg ctg gag  gcg ctg ctg        7281
Gln Phe  Thr Asp Met Glu His  Asn Arg Val Leu Glu  Ala Leu Leu            
    2375                 2380                 2385                        

ccg ctg  aag ggc cta gag gag  cgt gtg gca gcc gcc  gtg gac ctg        7326
Pro Leu  Lys Gly Leu Glu Glu  Arg Val Ala Ala Ala  Val Asp Leu            
    2390                 2395                 2400                        

atc atc  aag agc cac cag ggc  ctg gac cgc cag gag  ctg agc ttt        7371
Ile Ile  Lys Ser His Gln Gly  Leu Asp Arg Gln Glu  Leu Ser Phe            
    2405                 2410                 2415                        

gcg gcc  cgg tcc ttc tac tac  aag ctg cgt gcc gct  gag cag tac        7416
Ala Ala  Arg Ser Phe Tyr Tyr  Lys Leu Arg Ala Ala  Glu Gln Tyr            
    2420                 2425                 2430                        

aca ccc  aag gcc aag tac cat  ggc aac gtg atg cta  ctg cgc gcc        7461
Thr Pro  Lys Ala Lys Tyr His  Gly Asn Val Met Leu  Leu Arg Ala            
    2435                 2440                 2445                        

aag acg  ggt ggc gcc tac ggc  gag gac ctg ggc gcg  gac tac aac        7506
Lys Thr  Gly Gly Ala Tyr Gly  Glu Asp Leu Gly Ala  Asp Tyr Asn            
    2450                 2455                 2460                        

ctc tcc  cag gta tgc gac ggg  aaa gta tcc gtc cac  gtc atc gag        7551
Leu Ser  Gln Val Cys Asp Gly  Lys Val Ser Val His  Val Ile Glu            
    2465                 2470                 2475                        

ggt gac  cac cgc acg ctg ctg  gag ggc agc ggc ctg  gag tcc atc        7596
Gly Asp  His Arg Thr Leu Leu  Glu Gly Ser Gly Leu  Glu Ser Ile            
    2480                 2485                 2490                        

atc agc  atc atc cac agc tcc  ctg gct gag cca cgc  gtg agc gtg        7641
Ile Ser  Ile Ile His Ser Ser  Leu Ala Glu Pro Arg  Val Ser Val            
    2495                 2500                 2505                        

cgg gag  ggc tag gcccgtgccc ccgcctgcca ccggaggtca ctccaccatc          7693
Arg Glu  Gly                                                              
    2510                                                                  

cccaccccac cccaccccac ccccgccatg caacgggatt gaagggtcct gccggtggga     7753

ccctgtccgg cccagtgcca ctgccccccg aggctgctag atgtaggtgt taggcatgtc     7813

ccacccaccc gccgcctccc acggcacctc ggggacacca gagctgccga cttggagact     7873

cctggtctgt gaagagccgg tggtgcccgt gcccgcagga actgggctgg gcctcgtgcg     7933

cccgtggggt ctgcgcttgg tctttctgtg cttggatttg catatttatt gcattgctgg     7993

tagagacccc caggcctgtc caccctgcca agactcctca ggcagcgtgt gggtcccgca     8053

ctctgccccc atttccccga tgtcccctgc gggcgcgggc agccacccaa gcctgctggc     8113

tgcggccccc tctcggccag gcattggctc agcccgctga gtggggggtc gtgggccagt     8173

ccccgaggag ctgggcccct gcacaggcac acagggcccg gccacaccca gcggcccccc     8233

gcacagccac ccgtggggtg ctgcccttat gcccggcgcc gggcaccaac tccatgtttg     8293

gtgtttgtct gtgtttgttt ttcaagaaat gattcaaatt gctgcttgga ttttgaaatt     8353

tactgtaact gtcagtgtac acgtctggac cccgtttcat ttttacacca atttggtaaa     8413

aatgctgctc tcagcctccc acaattaaac cgcatgtgat ctccaaaaaa aaaaaaaaaa     8473

aaaaaaaa                                                              8481

