                         SEQUENCE LISTING

<110>  Tzartos, Socrates
 
<120>  Biomarker

<130>  P045457PCT

<150>  GR 20110100593
<151>  2011-10-17

<160>  10    

<170>  PatentIn version 3.5

<210>  1
<211>  850
<212>  DNA
<213>  Homo sapiens

<400>  1
gtacaaaaaa gcaggctcca ccatggccag cgagttcaag aagaagctct tctggagggc       60

agtggtggcc gagttcctgg ccacgaccct ctttgtcttc atcagcatcg gttctgccct      120

gggcttcaaa tacccggtgg ggaacaacca gacgacggtc caggacaacg tgaaggtgtc      180

gctggccttc gggctgagca tcgccacgct ggcgcagagt gtgggccaca tcagcggcgc      240

ccacctcaac ccggctgtca cactggggct gctgctcagc tgccagatca gcatcttccg      300

tgccctcatg tacatcatcg cccagtgcgt gggggccatc gtcgccaccg ccatcctctc      360

aggcatcacc tcctccctga ctgggaactc gcttggccgc aatgacctgg ctgatggtgt      420

gaactcgggc cagggcctgg gcatcgagat catcgggacc ctccagctgg tgctatgcgt      480

gctggctact accgaccgga ggcgccgtga ccttggtggc tcagcccccc ttgccatcgg      540

cctctctgta gcccttggac acctcctggc tattgactac actggctgtg ggattaaccc      600

tgctcggtcc tttggctccg cggtgatcac acacaacttc agcaaccact ggattttctg      660

ggtggggcca ttcatcgggg gagccctggc tgtactcatc tacgacttca tcctggcccc      720

acgcagcagt gacctcacag accgcgtgaa ggtgtggacc agcggccagg tggaggagta      780

tgacctggat gccgacgaca tcaactccag ggtggagatg aagcccaaat tggacccagc      840

tttcttgtac                                                             850


<210>  2
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Ser Glu Phe Lys Lys Lys Leu Phe Trp Arg Ala Val Val Ala 
1               5                   10                  15      


Glu Phe Leu Ala Thr Thr Leu Phe Val Phe Ile Ser Ile Gly Ser Ala 
            20                  25                  30          


Leu Gly Phe Lys Tyr Pro Val Gly Asn Asn Gln Thr Ala Val Gln Asp 
        35                  40                  45              


Asn Val Lys Val Ser Leu Ala Phe Gly Leu Ser Ile Ala Thr Leu Ala 
    50                  55                  60                  


Gln Ser Val Gly His Ile Ser Gly Ala His Leu Asn Pro Ala Val Thr 
65                  70                  75                  80  


Leu Gly Leu Leu Leu Ser Cys Gln Ile Ser Ile Phe Arg Ala Leu Met 
                85                  90                  95      


Tyr Ile Ile Ala Gln Cys Val Gly Ala Ile Val Ala Thr Ala Ile Leu 
            100                 105                 110         


Ser Gly Ile Thr Ser Ser Leu Thr Gly Asn Ser Leu Gly Arg Asn Asp 
        115                 120                 125             


Leu Ala Asp Gly Val Asn Ser Gly Gln Gly Leu Gly Ile Glu Ile Ile 
    130                 135                 140                 


Gly Thr Leu Gln Leu Val Leu Cys Val Leu Ala Thr Thr Asp Arg Arg 
145                 150                 155                 160 


Arg Arg Asp Leu Gly Gly Ser Ala Pro Leu Ala Ile Gly Leu Ser Val 
                165                 170                 175     


Ala Leu Gly His Leu Leu Ala Ile Asp Tyr Thr Gly Cys Gly Ile Asn 
            180                 185                 190         


Pro Ala Arg Ser Phe Gly Ser Ala Val Ile Thr His Asn Phe Ser Asn 
        195                 200                 205             


His Trp Ile Phe Trp Val Gly Pro Phe Ile Gly Gly Ala Leu Ala Val 
    210                 215                 220                 


Leu Ile Tyr Asp Phe Ile Leu Ala Pro Arg Ser Ser Asp Leu Thr Asp 
225                 230                 235                 240 


Arg Val Lys Val Trp Thr Ser Gly Gln Val Glu Glu Tyr Asp Leu Asp 
                245                 250                 255     


Ala Asp Asp Ile Asn Ser Arg Val Glu Met Lys Pro Lys 
            260                 265                 


<210>  3
<211>  995
<212>  DNA
<213>  Homo sapiens

<400>  3
agtgcgagag cgagtgcccg gagcatcctg gccctgagac agctgggcca gccccgcagg       60

gctctgcagc atgtgggagc tccgctccat agccttctcc agggctgtgt tcgcagagtt      120

cctggccaca ctcctcttcg tcttctttgg cctcggctct gccctcaact ggccacaggc      180

cctgccctct gtgctacaga ttgccatggc gtttggcttg ggtattggca ccctggtaca      240

ggctctgggc cacataagcg gggcccacat caaccctgcc gtgactgtgg cctgcctggt      300

gggctgccac gtctccgttc tccgagccgc cttctacgtg gctgcccagc tgctgggggc      360

tgtggccgga gccgctctgc tccatgagat cacgccagca gacatccgcg gggacctggc      420

tgtcaatgct gtgagtagcc acaactttgc tcttctctgt ccccagctca gcaacagcac      480

gacggctggc caggcggtga ctgtggagct cttcctgaca ctgcagctgg tgctctgcat      540

cttcgcctcc accgatgagc gccgcggaga gaacccgggc acccctgctc tctccatagg      600

cttctccgtg gccctgggcc acctccttgg ggtaggtcat ggccatgccc tcctcccact      660

gcagatccat tacaccggct gctctatgaa tcctgcccgc tccctggctc cagctgtcgt      720

cactggcaaa tttgatgacc actgggtaat ggctgaatcc gctcgccccc aggtcttctg      780

gatcggaccc ctggtgggcg ccatcctggg ctccctcctc tacaactacg tgctgtttcc      840

gccagccaag agcctgtcgg agcgcctggc agtgctgaag ggcctggagc cggacaccga      900

ttgggaggag cgcgaggtgc gacggcggca gtcggtggag ctgcactcgc cgcagagcct      960

gccacggggt accaaggcct gagggccgcc agcgg                                 995


<210>  4
<211>  271
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Trp Glu Leu Arg Ser Ile Ala Phe Ser Arg Ala Val Phe Ala Glu 
1               5                   10                  15      


Phe Leu Ala Thr Leu Leu Phe Val Phe Phe Gly Leu Gly Ser Ala Leu 
            20                  25                  30          


Asn Trp Pro Gln Ala Leu Pro Ser Val Leu Gln Ile Ala Met Ala Phe 
        35                  40                  45              


Gly Leu Gly Ile Gly Thr Leu Val Gln Ala Leu Gly His Ile Ser Gly 
    50                  55                  60                  


Ala His Ile Asn Pro Ala Val Thr Val Ala Cys Leu Val Gly Cys His 
65                  70                  75                  80  


Val Ser Val Leu Arg Ala Ala Phe Tyr Val Ala Ala Gln Leu Leu Gly 
                85                  90                  95      


Ala Val Ala Gly Ala Ala Leu Leu His Glu Ile Thr Pro Ala Asp Ile 
            100                 105                 110         


Arg Gly Asp Leu Ala Val Asn Ala Leu Ser Asn Ser Thr Thr Ala Gly 
        115                 120                 125             


Gln Ala Val Thr Val Glu Leu Phe Leu Thr Leu Gln Leu Val Leu Cys 
    130                 135                 140                 


Ile Phe Ala Ser Thr Asp Glu Arg Arg Gly Glu Asn Pro Gly Thr Pro 
145                 150                 155                 160 


Ala Leu Ser Ile Gly Phe Ser Val Ala Leu Gly His Leu Leu Gly Ile 
                165                 170                 175     


His Tyr Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Leu Ala Pro Ala 
            180                 185                 190         


Val Val Thr Gly Lys Phe Asp Asp His Trp Val Phe Trp Ile Gly Pro 
        195                 200                 205             


Leu Val Gly Ala Ile Leu Gly Ser Leu Leu Tyr Asn Tyr Val Leu Phe 
    210                 215                 220                 


Pro Pro Ala Lys Ser Leu Ser Glu Arg Leu Ala Val Leu Lys Gly Leu 
225                 230                 235                 240 


Glu Pro Asp Thr Asp Trp Glu Glu Arg Glu Val Arg Arg Arg Gln Ser 
                245                 250                 255     


Val Glu Leu His Ser Pro Gln Ser Leu Pro Arg Gly Thr Lys Ala 
            260                 265                 270     


<210>  5
<211>  848
<212>  DNA
<213>  Homo sapiens

<400>  5
gggtccgtgg gtctgtcctc tgtggggtgg ggggcaggtc ttcaaggtct gggctcagcg       60

ccctgactcg tgccctgtct ccaccaggtt ttctgggtag ggcccatcgt gggggcggtc      120

ctggctgcca tcctttactt ctacctgctc ttccccaact ccctgagcct gagtgagcgt      180

gtggccatca tcaaaggcac gtatgagcct gacgaggact gggaggagca gcgggaagag      240

cggaagaaga ccatggagct gaccacccgc tgaccagtgt caggcagggg ccagcccctc      300

agcccctgag ccaaggggga aaagaagaaa aagatcctaa cacaagcttc ctttttgcac      360

aaccggtcct cttggctgag gaggaggagc tggtcaccct ggctgcacag ttagagaggg      420

gagaaggaac ccatgatggg actcctgggg taggggccag gggctggggt ctgctgggga      480

caggtctctc tgggacagac ctcagagatt ctcaatgcag tgccaagctc acaggctgca      540

agggccaggc cagaaaaggg tgggcctgca gcctgcaccc cccaccttcc ccaacccttc      600

ctcaagagct gaagggatcc cagaccctag gtgggcagag gcagaccctc cccagagctc      660

cttaggaaga agacagactg gttcattgaa tgccgcctta tttatttctg gtgaggatgc      720

atgcgtgggg ctgctggtct ttagagtggg ggctacccaa taaatcactg atactcacat      780

tccgcctctg tctctcctca gagtgccttg agacactctg ccccattgcc tctcctcttt      840

gtcatccc                                                               848


<210>  6
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Lys Lys Glu Val Cys Ser Val Ala Phe Leu Lys Ala Val Phe Ala 
1               5                   10                  15      


Glu Phe Leu Ala Thr Leu Ile Phe Val Phe Phe Gly Leu Gly Ser Ala 
            20                  25                  30          


Leu Lys Trp Pro Ser Ala Leu Pro Thr Ile Leu Gln Ile Ala Leu Ala 
        35                  40                  45              


Phe Gly Leu Ala Ile Gly Thr Leu Ala Gln Ala Leu Gly Pro Val Ser 
    50                  55                  60                  


Gly Gly His Ile Asn Pro Ala Ile Thr Leu Ala Leu Leu Val Gly Asn 
65                  70                  75                  80  


Gln Ile Ser Leu Leu Arg Ala Phe Phe Tyr Val Ala Ala Gln Leu Val 
                85                  90                  95      


Gly Ala Ile Ala Gly Ala Gly Ile Leu Tyr Gly Val Ala Pro Leu Asn 
            100                 105                 110         


Ala Arg Gly Asn Leu Ala Val Asn Ala Leu Asn Asn Asn Thr Thr Gln 
        115                 120                 125             


Gly Gln Ala Met Val Val Glu Leu Ile Leu Thr Phe Gln Leu Ala Leu 
    130                 135                 140                 


Cys Ile Phe Ala Ser Thr Asp Ser Arg Arg Thr Ser Pro Val Gly Ser 
145                 150                 155                 160 


Pro Ala Leu Ser Ile Gly Leu Ser Val Thr Leu Gly His Leu Val Gly 
                165                 170                 175     


Ile Tyr Phe Thr Gly Cys Ser Met Asn Pro Ala Arg Ser Phe Gly Pro 
            180                 185                 190         


Ala Val Val Met Asn Arg Phe Ser Pro Ala His Trp Val Phe Trp Val 
        195                 200                 205             


Gly Pro Ile Val Gly Ala Val Leu Ala Ala Ile Leu Tyr Phe Tyr Leu 
    210                 215                 220                 


Leu Phe Pro Asn Ser Leu Ser Leu Ser Glu Arg Val Ala Ile Ile Lys 
225                 230                 235                 240 


Gly Thr Tyr Glu Pro Asp Glu Asp Trp Glu Glu Gln Arg Glu Glu Arg 
                245                 250                 255     


Lys Lys Thr Met Glu Leu Thr Thr Arg 
            260                 265 


<210>  7
<211>  1258
<212>  DNA
<213>  Homo sapiens

<400>  7
ggctctggac tggggacaca gggatagctg agccccagct gggggtggaa gctgagccag       60

ggacagtcac ggaggaacaa gatcaagatg cgctgtaact gagaagcccc caaggcggag      120

gctgagaatc agagacattt cagcagacat ctacaaatct gaaagacaaa acatggttca      180

agcatccggg cacaggcggt ccacccgtgg ctccaaaatg gtctcctggt ccgtgatagc      240

aaagatccag gaaatactgc agaggaagat ggtgcgagag ttcctggccg agttcatgag      300

cacatatgtc atgatggtat tcggccttgg ttccgtggcc catatggttc taaataaaaa      360

atatgggagc taccttggtg tcaacttggg ttttggcttc ggagtcacca tgggagtgca      420

cgtggcaggc cgcatctctg gagcccacat gaacgcagct gtgacctttg ctaactgtgc      480

gctgggccgc gtgccctgga ggaagtttcc ggtctatgtg ctggggcagt tcctgggctc      540

cttcctggcg gctgccacca tctacagtct cttctacacg gccattctcc acttttcggg      600

tggacagctg atggtgaccg gtcccgtcgc tacagctggc atttttgcca cctaccttcc      660

tgatcacatg acattgtggc ggggcttcct gaatgaggcg tggctgaccg ggatgctcca      720

gctgtgtctc ttcgccatca cggaccagga gaacaaccca gcactgccag gaacagaggc      780

gctggtgata ggcatcctcg tggtcatcat cggggtgtcc cttggcatga acacaggata      840

tgccatcaac ccgtcccggg acctgccccc ccgcatcttc accttcattg ctggttgggg      900

caaacaggtc ttcagcaatg gggagaactg gtggtgggtg ccagtggtgg caccacttct      960

gggtgcctat ctaggtggca tcatctacct ggtcttcatt ggctccacca tcccacggga     1020

gcccctgaaa ttggaggatt ctgtggcgta tgaagaccac gggataaccg tattgcccaa     1080

gatgggatct catgaaccca cgatctctcc cctcaccccc gtctctgtga gccctgccaa     1140

cagatcttca gtccaccctg ccccaccctt acatgaatcc atggccctag agcacttcta     1200

agcagagatt atttgtgatc ccatccattc cccaataaag caaggcttgt ccgacaaa       1258


<210>  8
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Val Gln Ala Ser Gly His Arg Arg Ser Thr Arg Gly Ser Lys Met 
1               5                   10                  15      


Val Ser Trp Ser Val Ile Ala Lys Ile Gln Glu Ile Leu Gln Arg Lys 
            20                  25                  30          


Met Val Arg Glu Phe Leu Ala Glu Phe Met Ser Thr Tyr Val Met Met 
        35                  40                  45              


Val Phe Gly Leu Gly Ser Val Ala His Met Val Leu Asn Lys Lys Tyr 
    50                  55                  60                  


Gly Ser Tyr Leu Gly Val Asn Leu Gly Phe Gly Phe Gly Val Thr Met 
65                  70                  75                  80  


Gly Val His Val Ala Gly Arg Ile Ser Gly Ala His Met Asn Ala Ala 
                85                  90                  95      


Val Thr Phe Ala Asn Cys Ala Leu Gly Arg Val Pro Trp Arg Lys Phe 
            100                 105                 110         


Pro Val Tyr Val Leu Gly Gln Phe Leu Gly Ser Phe Leu Ala Ala Ala 
        115                 120                 125             


Thr Ile Tyr Ser Leu Phe Tyr Thr Ala Ile Leu His Phe Ser Gly Gly 
    130                 135                 140                 


Gln Leu Met Val Thr Gly Pro Val Ala Thr Ala Gly Ile Phe Ala Thr 
145                 150                 155                 160 


Tyr Leu Pro Asp His Met Thr Leu Trp Arg Gly Phe Leu Asn Glu Ala 
                165                 170                 175     


Trp Leu Thr Gly Met Leu Gln Leu Cys Leu Phe Ala Ile Thr Asp Gln 
            180                 185                 190         


Glu Asn Asn Pro Ala Leu Pro Gly Thr Glu Ala Leu Val Ile Gly Ile 
        195                 200                 205             


Leu Val Val Ile Ile Gly Val Ser Leu Gly Met Asn Thr Gly Tyr Ala 
    210                 215                 220                 


Ile Asn Pro Ser Arg Asp Leu Pro Pro Arg Ile Phe Thr Phe Ile Ala 
225                 230                 235                 240 


Gly Trp Gly Lys Gln Val Phe Ser Asn Gly Glu Asn Trp Trp Trp Val 
                245                 250                 255     


Pro Val Val Ala Pro Leu Leu Gly Ala Tyr Leu Gly Gly Ile Ile Tyr 
            260                 265                 270         


Leu Val Phe Ile Gly Ser Thr Ile Pro Arg Glu Pro Leu Lys Leu Glu 
        275                 280                 285             


Asp Ser Val Ala Tyr Glu Asp His Gly Ile Thr Val Leu Pro Lys Met 
    290                 295                 300                 


Gly Ser His Glu Pro Thr Ile Ser Pro Leu Thr Pro Val Ser Val Ser 
305                 310                 315                 320 


Pro Ala Asn Arg Ser Ser Val His Pro Ala Pro Pro Leu His Glu Ser 
                325                 330                 335     


Met Ala Leu Glu His Phe 
            340         


<210>  9
<211>  1309
<212>  DNA
<213>  Homo sapiens

<400>  9
taggagataa gagtatcttg cacagcaggt gcaggtttcc cagcagctca ggcaagagtc       60

cgatgtttgt gccatctgat cctgatgtct ggagagatag ccatgtgtga gcctgaattt      120

ggcaatgaca aggccaggga gccgagcgtg ggtggcaggt ggcgagtgtc ctggtacgaa      180

cggtttgtgc agccatgtct ggtcgaactg ctgggctctg ctctcttcat cttcatcggg      240

tgcctgtcgg tcattgagaa tgggacggac actgggctgc tgcagccggc cctggcccac      300

gggctggctt tggggctcgt gattgccacg ctggggaata tcagtggtgg acacttcaac      360

cctgcggtgt ccctggcagc catgctgatc ggaggcctca acctggtgat gctcctcccg      420

tactgggtct cacagctgct cggggggatg ctcggggctg ccttggccaa ggtggtgagt      480

cctgaggaga ggttctggaa tgcatctggg gcggcctttg tgacagtcca ggagcagggg      540

caggtggcag gggcgttggt ggcagagatc atcctgacga cgctgctggc cctggctgta      600

tgcatgggtg ccatcaatga gaagacaaag ggccctctgg ccccgttctc catcggcttt      660

gccgtcaccg tggatatcct ggctgggggc cctgtgtctg gaggctgcat gaatcccgcc      720

cgtgcttttg gacctgcggt ggtggccaac cactggaact tccactggat ctactggctg      780

ggcccactcc tggctggcct gcttgttgga ctgctcatta ggtgcttcat tggagatggg      840

aagacccgcc tcatcctgaa ggctcggtga gcagagctcg tgggattcct gctgctccag      900

gtgtcctcag ctcacctgtc ccagactgag gacaggggag ttcctgcatt tcctgccagg      960

gcagaggccc agaggagcga ccccctgctt ccactgcttg ggcctgcttt ctcagataga     1020

ctgactgctg aggaggctct aggttcttgg aattcctttg tgctcatcag agaccccagc     1080

ctggggaaca cgctgcccgc actgcccaga gagcagtgca aacaccacaa cacgagcgtg     1140

tttcttgaga ggaatgtccc cgagttggac aaggaggctg tttctgcaca tcagctcatt     1200

tcccgcaccc catttcttgc ttgattgctt tgttgggggc ctggccactt ccttgcttct     1260

caagctgaca attctcactt tgcaataaat agtccagtgt ttccttcat                 1309


<210>  10
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ser Gly Glu Ile Ala Met Cys Glu Pro Glu Phe Gly Asn Asp Lys 
1               5                   10                  15      


Ala Arg Glu Pro Ser Val Gly Gly Arg Trp Arg Val Ser Trp Tyr Glu 
            20                  25                  30          


Arg Phe Val Gln Pro Cys Leu Val Glu Leu Leu Gly Ser Ala Leu Phe 
        35                  40                  45              


Ile Phe Ile Gly Cys Leu Ser Val Ile Glu Asn Gly Thr Asp Thr Gly 
    50                  55                  60                  


Leu Leu Gln Pro Ala Leu Ala His Gly Leu Ala Leu Gly Leu Val Ile 
65                  70                  75                  80  


Ala Thr Leu Gly Asn Ile Ser Gly Gly His Phe Asn Pro Ala Val Ser 
                85                  90                  95      


Leu Ala Ala Met Leu Ile Gly Gly Leu Asn Leu Val Met Leu Leu Pro 
            100                 105                 110         


Tyr Trp Val Ser Gln Leu Leu Gly Gly Met Leu Gly Ala Ala Leu Ala 
        115                 120                 125             


Lys Ala Val Ser Pro Glu Glu Arg Phe Trp Asn Ala Ser Gly Ala Ala 
    130                 135                 140                 


Phe Val Thr Val Gln Glu Gln Gly Gln Val Ala Gly Ala Leu Val Ala 
145                 150                 155                 160 


Glu Ile Ile Leu Thr Thr Leu Leu Ala Leu Ala Val Cys Met Gly Ala 
                165                 170                 175     


Ile Asn Glu Lys Thr Lys Gly Pro Leu Ala Pro Phe Ser Ile Gly Phe 
            180                 185                 190         


Ala Val Thr Val Asp Ile Leu Ala Gly Gly Pro Val Ser Gly Gly Cys 
        195                 200                 205             


Met Asn Pro Ala Arg Ala Phe Gly Pro Ala Val Val Ala Asn His Trp 
    210                 215                 220                 


Asn Phe His Trp Ile Tyr Trp Leu Gly Pro Leu Leu Ala Gly Leu Leu 
225                 230                 235                 240 


Val Gly Leu Leu Ile Arg Cys Phe Ile Gly Asp Gly Lys Thr Arg Leu 
                245                 250                 255     


Ile Leu Lys Ala Arg 
            260     


