                         SEQUENCE LISTING

<110>  Heinrich-Heine-Universitt Dsseldorf
 
<120>  AGENTS AND METHODS FOR THE EXPRESSION AND SECRETION OF PEPTIDES 
       AND PROTEINS

<130>  P50xxx

<150>  EP11186225
<151>  2011-10-21

<160>  338   

<170>  PatentIn version 3.5

<210>  1
<211>  522
<212>  DNA
<213>  Artificial

<220>
<223>  3' Fragment of HlyC + gap

<400>  1
gaatataaac aaaccattag agattcttgg gcatgtatcc tggctatggg ccagttctcc       60

actacacaga aactggccag tatctttgtt tgcaataaat gtattacccg caatacaggc      120

taaccaatat gttttattaa cccgggatga ttaccctgtc gcgtattgta gttgggctaa      180

tttaagttta gaaaatgaaa ttaaatatct taatgatgtt acctcattag ttgcagaaga      240

ctggacttca ggtgatcgta aatggttcat tgactggatt gctcctttcg gggataacgg      300

tgccctgtac aaatatatgc gaaaaaaatt ccctgatgaa ctattcagag ccatcagggt      360

ggatcccaaa actcatgttg gtaaagtatc agaatttcat ggaggtaaaa ttgataaaca      420

gttagcgaat aaaattttta aacaatatca ccacgagtta ataactgaag taaaaagaaa      480

gtcagatttt aatttttcat taactggtta agaggtaatt aa                         522


<210>  2
<211>  11
<212>  DNA
<213>  Artificial

<220>
<223>  Gap sequence between HlyC and HlyA genes

<400>  2
gaggtaatta a                                                            11


<210>  3
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  3
taagaggtaa ttaa                                                         14


<210>  4
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  4
ttaagaggta attaa                                                        15


<210>  5
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  5
ggttaagagg taattaa                                                      17


<210>  6
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  6
ttaactggtt aagaggtaat taa                                               23


<210>  7
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  7
aatttttcat taactggtta agaggtaatt aa                                     32


<210>  8
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  8
tcagatttta atttttcatt aactggttaa gaggtaatta a                           41


<210>  9
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  9
ataactgaag taaaaagaaa gtcagatttt aatttttcat taactggtta agaggtaatt       60

aa                                                                      62


<210>  10
<211>  83
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  10
aaacaatatc accacgagtt aataactgaa gtaaaaagaa agtcagattt taatttttca       60

ttaactggtt aagaggtaat taa                                               83


<210>  11
<211>  104
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  11
cagttagcga ataaaatttt taaacaatat caccacgagt taataactga agtaaaaaga       60

aagtcagatt ttaatttttc attaactggt taagaggtaa ttaa                       104


<210>  12
<211>  159
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  12
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaa                             159


<210>  13
<211>  219
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  13
cctgtacaaa tatatgcgaa aaaaattccc tgatgaacta ttcagagcca tcagggtgga       60

tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt      120

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      180

agattttaat ttttcattaa ctggttaaga ggtaattaa                             219


<210>  14
<211>  279
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  14
gacttcaggt gatcgtaaat ggttcattga ctggattgct cctttcgggg ataacggtgc       60

cctgtacaaa tatatgcgaa aaaaattccc tgatgaacta ttcagagcca tcagggtgga      120

tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt      180

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      240

agattttaat ttttcattaa ctggttaaga ggtaattaa                             279


<210>  15
<211>  339
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  15
aagtttagaa aatgaaatta aatatcttaa tgatgttacc tcattagttg cagaagactg       60

gacttcaggt gatcgtaaat ggttcattga ctggattgct cctttcgggg ataacggtgc      120

cctgtacaaa tatatgcgaa aaaaattccc tgatgaacta ttcagagcca tcagggtgga      180

tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt      240

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      300

agattttaat ttttcattaa ctggttaaga ggtaattaa                             339


<210>  16
<211>  399
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  16
ccaatatgtt ttattaaccc gggatgatta ccctgtcgcg tattgtagtt gggctaattt       60

aagtttagaa aatgaaatta aatatcttaa tgatgttacc tcattagttg cagaagactg      120

gacttcaggt gatcgtaaat ggttcattga ctggattgct cctttcgggg ataacggtgc      180

cctgtacaaa tatatgcgaa aaaaattccc tgatgaacta ttcagagcca tcagggtgga      240

tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt      300

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      360

agattttaat ttttcattaa ctggttaaga ggtaattaa                             399


<210>  17
<211>  459
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  17
acacagaaac tggccagtat ctttgtttgc aataaatgta ttacccgcaa tacaggctaa       60

ccaatatgtt ttattaaccc gggatgatta ccctgtcgcg tattgtagtt gggctaattt      120

aagtttagaa aatgaaatta aatatcttaa tgatgttacc tcattagttg cagaagactg      180

gacttcaggt gatcgtaaat ggttcattga ctggattgct cctttcgggg ataacggtgc      240

cctgtacaaa tatatgcgaa aaaaattccc tgatgaacta ttcagagcca tcagggtgga      300

tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt      360

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      420

agattttaat ttttcattaa ctggttaaga ggtaattaa                             459


<210>  18
<211>  521
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  18
aatataaaca aaccattaga gattcttggg catgtatcct ggctatgggc cagttctcca       60

ctacacagaa actggccagt atctttgttt gcaataaatg tattacccgc aatacaggct      120

aaccaatatg ttttattaac ccgggatgat taccctgtcg cgtattgtag ttgggctaat      180

ttaagtttag aaaatgaaat taaatatctt aatgatgtta cctcattagt tgcagaagac      240

tggacttcag gtgatcgtaa atggttcatt gactggattg ctcctttcgg ggataacggt      300

gccctgtaca aatatatgcg aaaaaaattc cctgatgaac tattcagagc catcagggtg      360

gatcccaaaa ctcatgttgg taaagtatca gaatttcatg gaggtaaaat tgataaacag      420

ttagcgaata aaatttttaa acaatatcac cacgagttaa taactgaagt aaaaagaaag      480

tcagatttta atttttcatt aactggttaa gaggtaatta a                          521


<210>  19
<211>  474
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  19
ggccagttct ccactacaca gaaactggcc agtatctttg tttgcaataa atgtattacc       60

cgcaatacag gctaaccaat atgttttatt aacccgggat gattaccctg tcgcgtattg      120

tagttgggct aatttaagtt tagaaaatga aattaaatat cttaatgatg ttacctcatt      180

agttgcagaa gactggactt caggtgatcg taaatggttc attgactgga ttgctccttt      240

cggggataac ggtgccctgt acaaatatat gcgaaaaaaa ttccctgatg aactattcag      300

agccatcagg gtggatccca aaactcatgt tggtaaagta tcagaatttc atggaggtaa      360

aattgataaa cagttagcga ataaaatttt taaacaatat caccacgagt taataactga      420

agtaaaaaga aagtcagatt ttaatttttc attaactggt taagaggtaa ttaa            474


<210>  20
<211>  424
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  20
atgtattacc cgcaatacag gctaaccaat atgttttatt aacccgggat gattaccctg       60

tcgcgtattg tagttgggct aatttaagtt tagaaaatga aattaaatat cttaatgatg      120

ttacctcatt agttgcagaa gactggactt caggtgatcg taaatggttc attgactgga      180

ttgctccttt cggggataac ggtgccctgt acaaatatat gcgaaaaaaa ttccctgatg      240

aactattcag agccatcagg gtggatccca aaactcatgt tggtaaagta tcagaatttc      300

atggaggtaa aattgataaa cagttagcga ataaaatttt taaacaatat caccacgagt      360

taataactga agtaaaaaga aagtcagatt ttaatttttc attaactggt taagaggtaa      420

ttaa                                                                   424


<210>  21
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  21
aattaaatat cttaatgatg ttacctcatt agttgcagaa gactggactt caggtgatcg       60

taaatggttc attgactgga ttgctccttt cggggataac ggtgccctgt acaaatatat      120

gcgaaaaaaa ttccctgatg aactattcag agccatcagg gtggatccca aaactcatgt      180

tggtaaagta tcagaatttc atggaggtaa aattgataaa cagttagcga ataaaatttt      240

taaacaatat caccacgagt taataactga agtaaaaaga aagtcagatt ttaatttttc      300

attaactggt taagaggtaa ttaa                                             324


<210>  22
<211>  124
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  22
atggaggtaa aattgataaa cagttagcga ataaaatttt taaacaatat caccacgagt       60

taataactga agtaaaaaga aagtcagatt ttaatttttc attaactggt taagaggtaa      120

ttaa                                                                   124


<210>  23
<211>  111
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  23
tgataaacag ttagcgaata aaatttttaa acaatatcac cacgagttaa taactgaagt       60

aaaaagaaag tcagatttta atttttcatt aactggttaa gaggtaatta a               111


<210>  24
<211>  86
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  24
tttaaacaat atcaccacga gttaataact gaagtaaaaa gaaagtcaga ttttaatttt       60

tcattaactg gttaagaggt aattaa                                            86


<210>  25
<211>  61
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  25
taactgaagt aaaaagaaag tcagatttta atttttcatt aactggttaa gaggtaatta       60

a                                                                       61


<210>  26
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  26
ttttaatttt tcattaactg gttaagaggt aattaa                                 36


<210>  27
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of HlyC + gap

<400>  27
aactggttaa gaggtaatta a                                                 21


<210>  28
<211>  10
<212>  DNA
<213>  Artificial

<220>
<223>  3' fragment of gap sequence between HlyC and HlyA genes

<400>  28
aggtaattaa                                                              10


<210>  29
<211>  3072
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  29
atgacaacaa taaccactgc acaaattaaa agcacactgc agtctgcaaa gcaatccgct       60

gcaaataaat tgcactcagc aggacaaagc acgaaagatg cattaaaaaa agcagcagag      120

caaacccgca atgcgggaaa cagactcatt ttacttatcc ctaaagatta taaaggacag      180

ggttcaagcc ttaatgacct tgtcaggacg gcagatgaac tgggaattga agtccagtat      240

gatgaaaaga atggcacggc gattactaaa caggtgttcg gcacagcaga gaaactcatt      300

ggcctcaccg aacggggagt gactatcttt gcaccacaat tagacaaatt actgcaaaag      360

tatcaaaaag caggtaatat attaggtggc ggtgctgaaa atatcggtga taacttagga      420

aaggcaggcg gtatattgtc aacgtttcaa aatttcctgg gtactgcact ttcctcaatg      480

aaaatagacg aactgataaa gaaacaaaaa tctggtggca atgtcagttc ttctgagatg      540

gcagaagcga gtattgagct aatcaatcaa cttgtggata cagttgccag ccttaataat      600

aatgttaact cattttctca acaactcaat actctgggaa gtgtattatc caatacaaag      660

cacctgaacg gtgttggtaa taagttacag aatttaccta atcttgataa tatcggtgca      720

gggttagata ctgtatcggg tattttatct gcgatttcag caagcttcat tctgagcaat      780

gcagatgcag ataccagaac taaagctgca gcaggtgttg aattaacaac gaaagtactg      840

ggtaatgttg gaaaaggtat ttctcaatat attatcgcac agcgcgctgc acaggggtta      900

tctacatctg ctgctgctgc cggtttaatt gcttctgctg tgacactagc aattagtccc      960

ctctcattcc tgtccattgc cgataagttt aaacgtgcca ataaaataga ggagtattca     1020

caacgattca aaaaacttgg atacgatggt gacagtttac ttgctgcttt ccacaaagaa     1080

acaggggcta ttgatgcatc attaacaacg ataagcactg tactggcttc agtatcttca     1140

ggtattagtg ctgctgcaac gacatctctg gttggtgcac cggtaagcgc gctggtaggc     1200

gctgttacgg ggataatttc aggtatcctt gaggcttcaa agcaggcaat gtttgaacat     1260

gttgccagta aaatggctga tgttattgct gaatgggaga aaaaacacgg caaaaattac     1320

tttgaaaatg gatatgatgc ccgccatgct gcatttttag aagataactt taaaatatta     1380

tctcagtata ataaagagta ttctgttgaa agatcagtcc tcattaccca gcaacattgg     1440

gatacgctga taggtgagtt agctggtgtc accagaaatg gagacaaaac actcagtggt     1500

aaaagttata ttgactatta tgaagaagga aaacgtctgg agaaaaaacc ggatgaattc     1560

cagaagcaag tctttgaccc attgaaagga aatattgacc tttctgacag caaatcttct     1620

acgttattga aatttgttac gccattatta actcccggtg aggaaattcg tgaaaggagg     1680

cagtccggaa aatatgaata tattaccgag ttattagtca agggtgttga taaatggacg     1740

gtgaaggggg ttcaggacaa gggggctgta tatgattact ctaacctgat tcagcatgca     1800

tcagtcggta ataaccagta tcgggaaatc cgtattgagt cacacctggg agacggggat     1860

gataaggtct ttttatctgc cggctcagcc aatatctacg caggtaaagg acatgatgtt     1920

gtttattatg ataaaacaga cactggttat ctgaccattg atggcacaaa agcaaccgaa     1980

gcgggtaatt acacggtaac acgtgtactt ggtggcgatg ttaaggtttt acaggaagtt     2040

gtgaaggagc aggaggtttc agtcggaaaa agaactgaaa aaacgcaata tcggagttat     2100

gaattcactc atatcaatgg taaaaattta acagagactg ataacttata ttccgtggaa     2160

gaacttattg ggaccacgcg tgccgacaag ttttttggca gtaaatttac tgatatcttc     2220

catggcgcgg atggtgatga ccttatagaa ggaaatgatg ggaatgaccg cttatatggt     2280

gataaaggta atgacacact gagtggtgga aacggagatg accagctcta tggcggtgat     2340

ggtaacgata agttgattgg gggagcaggt aataattacc tgaacggcgg agatggagat     2400

gatgagcttc aggttcaggg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt     2460

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat     2520

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat     2580

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg     2640

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt     2700

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt     2760

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct     2820

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat     2880

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc     2940

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct     3000

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg     3060

accacatcag ca                                                         3072


<210>  30
<211>  126
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  30
ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga tgttaaagag       60

gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt ttcatatgga      120

cggaac                                                                 126


<210>  31
<211>  3069
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  31
acaacaataa ccactgcaca aattaaaagc acactgcagt ctgcaaagca atccgctgca       60

aataaattgc actcagcagg acaaagcacg aaagatgcat taaaaaaagc agcagagcaa      120

acccgcaatg cgggaaacag actcatttta cttatcccta aagattataa aggacagggt      180

tcaagcctta atgaccttgt caggacggca gatgaactgg gaattgaagt ccagtatgat      240

gaaaagaatg gcacggcgat tactaaacag gtgttcggca cagcagagaa actcattggc      300

ctcaccgaac ggggagtgac tatctttgca ccacaattag acaaattact gcaaaagtat      360

caaaaagcag gtaatatatt aggtggcggt gctgaaaata tcggtgataa cttaggaaag      420

gcaggcggta tattgtcaac gtttcaaaat ttcctgggta ctgcactttc ctcaatgaaa      480

atagacgaac tgataaagaa acaaaaatct ggtggcaatg tcagttcttc tgagatggca      540

gaagcgagta ttgagctaat caatcaactt gtggatacag ttgccagcct taataataat      600

gttaactcat tttctcaaca actcaatact ctgggaagtg tattatccaa tacaaagcac      660

ctgaacggtg ttggtaataa gttacagaat ttacctaatc ttgataatat cggtgcaggg      720

ttagatactg tatcgggtat tttatctgcg atttcagcaa gcttcattct gagcaatgca      780

gatgcagata ccagaactaa agctgcagca ggtgttgaat taacaacgaa agtactgggt      840

aatgttggaa aaggtatttc tcaatatatt atcgcacagc gcgctgcaca ggggttatct      900

acatctgctg ctgctgccgg tttaattgct tctgctgtga cactagcaat tagtcccctc      960

tcattcctgt ccattgccga taagtttaaa cgtgccaata aaatagagga gtattcacaa     1020

cgattcaaaa aacttggata cgatggtgac agtttacttg ctgctttcca caaagaaaca     1080

ggggctattg atgcatcatt aacaacgata agcactgtac tggcttcagt atcttcaggt     1140

attagtgctg ctgcaacgac atctctggtt ggtgcaccgg taagcgcgct ggtaggcgct     1200

gttacgggga taatttcagg tatccttgag gcttcaaagc aggcaatgtt tgaacatgtt     1260

gccagtaaaa tggctgatgt tattgctgaa tgggagaaaa aacacggcaa aaattacttt     1320

gaaaatggat atgatgcccg ccatgctgca tttttagaag ataactttaa aatattatct     1380

cagtataata aagagtattc tgttgaaaga tcagtcctca ttacccagca acattgggat     1440

acgctgatag gtgagttagc tggtgtcacc agaaatggag acaaaacact cagtggtaaa     1500

agttatattg actattatga agaaggaaaa cgtctggaga aaaaaccgga tgaattccag     1560

aagcaagtct ttgacccatt gaaaggaaat attgaccttt ctgacagcaa atcttctacg     1620

ttattgaaat ttgttacgcc attattaact cccggtgagg aaattcgtga aaggaggcag     1680

tccggaaaat atgaatatat taccgagtta ttagtcaagg gtgttgataa atggacggtg     1740

aagggggttc aggacaaggg ggctgtatat gattactcta acctgattca gcatgcatca     1800

gtcggtaata accagtatcg ggaaatccgt attgagtcac acctgggaga cggggatgat     1860

aaggtctttt tatctgccgg ctcagccaat atctacgcag gtaaaggaca tgatgttgtt     1920

tattatgata aaacagacac tggttatctg accattgatg gcacaaaagc aaccgaagcg     1980

ggtaattaca cggtaacacg tgtacttggt ggcgatgtta aggttttaca ggaagttgtg     2040

aaggagcagg aggtttcagt cggaaaaaga actgaaaaaa cgcaatatcg gagttatgaa     2100

ttcactcata tcaatggtaa aaatttaaca gagactgata acttatattc cgtggaagaa     2160

cttattggga ccacgcgtgc cgacaagttt tttggcagta aatttactga tatcttccat     2220

ggcgcggatg gtgatgacct tatagaagga aatgatggga atgaccgctt atatggtgat     2280

aaaggtaatg acacactgag tggtggaaac ggagatgacc agctctatgg cggtgatggt     2340

aacgataagt tgattggggg agcaggtaat aattacctga acggcggaga tggagatgat     2400

gagcttcagg ttcagggaaa ttctcttgca aaaaatgtat tattcggtgg aaaaggtaat     2460

gacaagctgt acggcagtga gggggcagat ctgcttgatg gtggagaggg ggatgatctc     2520

ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg tcatcatatt     2580

attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat     2640

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt     2700

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat     2760

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat     2820

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg     2880

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc     2940

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta     3000

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc     3060

acatcagca                                                             3069


<210>  32
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  32
catggcgcgg atggtgatga ccttatagaa ggaaatgatg ggaatgaccg cttatatggt       60

gataaaggta atgacacact gagtggtgga aacggagatg accagctcta tggcggtgat      120

ggtaacgata agttgattgg gggagcaggt aataattacc tgaacggcgg agatggagat      180

gatgagcttc aggttcaggg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt      240

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat      300

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat      360

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg      420

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt      480

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt      540

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct      600

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat      660

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc      720

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct      780

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg      840

accacatcag ca                                                          852


<210>  33
<211>  708
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  33
gcaggtaata attacctgaa cggcggagat ggagatgatg agcttcaggt tcagggaaat       60

tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta cggcagtgag      120

ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg atatggtaat      180

gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga tggggggaaa      240

gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa gcgagaaggt      300

aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca taaaaatggt      360

attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca ccagatagag      420

cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa ggcacttgag      480

tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt agcctatgga      540

agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc agctgcaggt      600

agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc cggtaatgcc      660

agtgattttt catatggacg gaactcaata accctgacca catcagca                   708


<210>  34
<211>  654
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  34
ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag gtaatgacaa gctgtacggc       60

agtgaggggg cagatctgct tgatggtgga gagggggatg atctcctgaa aggcggatat      120

ggtaatgata tttatcgtta tctgtcagga tatggtcatc atattattga tgatgatggg      180

gggaaagagg ataaactcag tttggctgat attgatttcc gggatgtggc cttcaagcga      240

gaaggtaatg acctcatcat gtataaagct gaaggtaatg ttctttccat tggtcataaa      300

aatggtatta cattcaggaa ctggtttgaa aaagagtcag gtgatatctc taatcaccag      360

atagagcaga tttttgataa aagtggccgg ataatcacac ctgattccct taaaaaggca      420

cttgagtatc aacagcgtaa taataaggca agttatgtgt atgggaatga tgcattagcc      480

tatggaagtc agggtgatct taatccatta attaatgaaa tcagcaaaat catttcagct      540

gcaggtagct tcgatgttaa agaggaaaga actgcagctt ctttattgca gttgtccggt      600

aatgccagtg atttttcata tggacggaac tcaataaccc tgaccacatc agca            654


<210>  35
<211>  600
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  35
tacggcagtg agggggcaga tctgcttgat ggtggagagg gggatgatct cctgaaaggc       60

ggatatggta atgatattta tcgttatctg tcaggatatg gtcatcatat tattgatgat      120

gatgggggga aagaggataa actcagtttg gctgatattg atttccggga tgtggccttc      180

aagcgagaag gtaatgacct catcatgtat aaagctgaag gtaatgttct ttccattggt      240

cataaaaatg gtattacatt caggaactgg tttgaaaaag agtcaggtga tatctctaat      300

caccagatag agcagatttt tgataaaagt ggccggataa tcacacctga ttcccttaaa      360

aaggcacttg agtatcaaca gcgtaataat aaggcaagtt atgtgtatgg gaatgatgca      420

ttagcctatg gaagtcaggg tgatcttaat ccattaatta atgaaatcag caaaatcatt      480

tcagctgcag gtagcttcga tgttaaagag gaaagaactg cagcttcttt attgcagttg      540

tccggtaatg ccagtgattt ttcatatgga cggaactcaa taaccctgac cacatcagca      600


<210>  36
<211>  549
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  36
ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg tcatcatatt       60

attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat      120

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt      180

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat      240

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat      300

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg      360

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc      420

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta      480

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc      540

acatcagca                                                              549


<210>  37
<211>  489
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  37
attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat       60

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt      120

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat      180

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat      240

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg      300

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc      360

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta      420

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc      480

acatcagca                                                              489


<210>  38
<211>  450
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  38
gctgatattg atttccggga tgtggccttc aagcgagaag gtaatgacct catcatgtat       60

aaagctgaag gtaatgttct ttccattggt cataaaaatg gtattacatt caggaactgg      120

tttgaaaaag agtcaggtga tatctctaat caccagatag agcagatttt tgataaaagt      180

ggccggataa tcacacctga ttcccttaaa aaggcacttg agtatcaaca gcgtaataat      240

aaggcaagtt atgtgtatgg gaatgatgca ttagcctatg gaagtcaggg tgatcttaat      300

ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga tgttaaagag      360

gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt ttcatatgga      420

cggaactcaa taaccctgac cacatcagca                                       450


<210>  39
<211>  180
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  39
ttagcctatg gaagtcaggg tgatcttaat ccattaatta atgaaatcag caaaatcatt       60

tcagctgcag gtagcttcga tgttaaagag gaaagaactg cagcttcttt attgcagttg      120

tccggtaatg ccagtgattt ttcatatgga cggaactcaa taaccctgac cacatcagca      180


<210>  40
<211>  150
<212>  DNA
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  40
ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga tgttaaagag       60

gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt ttcatatgga      120

cggaactcaa taaccctgac cacatcagca                                       150


<210>  41
<211>  1024
<212>  PRT
<213>  Artificial

<220>
<223>  Artificial Sequence

<400>  41

Met Thr Thr Ile Thr Thr Ala Gln Ile Lys Ser Thr Leu Gln Ser Ala 
1               5                   10                  15      


Lys Gln Ser Ala Ala Asn Lys Leu His Ser Ala Gly Gln Ser Thr Lys 
            20                  25                  30          


Asp Ala Leu Lys Lys Ala Ala Glu Gln Thr Arg Asn Ala Gly Asn Arg 
        35                  40                  45              


Leu Ile Leu Leu Ile Pro Lys Asp Tyr Lys Gly Gln Gly Ser Ser Leu 
    50                  55                  60                  


Asn Asp Leu Val Arg Thr Ala Asp Glu Leu Gly Ile Glu Val Gln Tyr 
65                  70                  75                  80  


Asp Glu Lys Asn Gly Thr Ala Ile Thr Lys Gln Val Phe Gly Thr Ala 
                85                  90                  95      


Glu Lys Leu Ile Gly Leu Thr Glu Arg Gly Val Thr Ile Phe Ala Pro 
            100                 105                 110         


Gln Leu Asp Lys Leu Leu Gln Lys Tyr Gln Lys Ala Gly Asn Ile Leu 
        115                 120                 125             


Gly Gly Gly Ala Glu Asn Ile Gly Asp Asn Leu Gly Lys Ala Gly Gly 
    130                 135                 140                 


Ile Leu Ser Thr Phe Gln Asn Phe Leu Gly Thr Ala Leu Ser Ser Met 
145                 150                 155                 160 


Lys Ile Asp Glu Leu Ile Lys Lys Gln Lys Ser Gly Gly Asn Val Ser 
                165                 170                 175     


Ser Ser Glu Met Ala Glu Ala Ser Ile Glu Leu Ile Asn Gln Leu Val 
            180                 185                 190         


Asp Thr Val Ala Ser Leu Asn Asn Asn Val Asn Ser Phe Ser Gln Gln 
        195                 200                 205             


Leu Asn Thr Leu Gly Ser Val Leu Ser Asn Thr Lys His Leu Asn Gly 
    210                 215                 220                 


Val Gly Asn Lys Leu Gln Asn Leu Pro Asn Leu Asp Asn Ile Gly Ala 
225                 230                 235                 240 


Gly Leu Asp Thr Val Ser Gly Ile Leu Ser Ala Ile Ser Ala Ser Phe 
                245                 250                 255     


Ile Leu Ser Asn Ala Asp Ala Asp Thr Arg Thr Lys Ala Ala Ala Gly 
            260                 265                 270         


Val Glu Leu Thr Thr Lys Val Leu Gly Asn Val Gly Lys Gly Ile Ser 
        275                 280                 285             


Gln Tyr Ile Ile Ala Gln Arg Ala Ala Gln Gly Leu Ser Thr Ser Ala 
    290                 295                 300                 


Ala Ala Ala Gly Leu Ile Ala Ser Ala Val Thr Leu Ala Ile Ser Pro 
305                 310                 315                 320 


Leu Ser Phe Leu Ser Ile Ala Asp Lys Phe Lys Arg Ala Asn Lys Ile 
                325                 330                 335     


Glu Glu Tyr Ser Gln Arg Phe Lys Lys Leu Gly Tyr Asp Gly Asp Ser 
            340                 345                 350         


Leu Leu Ala Ala Phe His Lys Glu Thr Gly Ala Ile Asp Ala Ser Leu 
        355                 360                 365             


Thr Thr Ile Ser Thr Val Leu Ala Ser Val Ser Ser Gly Ile Ser Ala 
    370                 375                 380                 


Ala Ala Thr Thr Ser Leu Val Gly Ala Pro Val Ser Ala Leu Val Gly 
385                 390                 395                 400 


Ala Val Thr Gly Ile Ile Ser Gly Ile Leu Glu Ala Ser Lys Gln Ala 
                405                 410                 415     


Met Phe Glu His Val Ala Ser Lys Met Ala Asp Val Ile Ala Glu Trp 
            420                 425                 430         


Glu Lys Lys His Gly Lys Asn Tyr Phe Glu Asn Gly Tyr Asp Ala Arg 
        435                 440                 445             


His Ala Ala Phe Leu Glu Asp Asn Phe Lys Ile Leu Ser Gln Tyr Asn 
    450                 455                 460                 


Lys Glu Tyr Ser Val Glu Arg Ser Val Leu Ile Thr Gln Gln His Trp 
465                 470                 475                 480 


Asp Thr Leu Ile Gly Glu Leu Ala Gly Val Thr Arg Asn Gly Asp Lys 
                485                 490                 495     


Thr Leu Ser Gly Lys Ser Tyr Ile Asp Tyr Tyr Glu Glu Gly Lys Arg 
            500                 505                 510         


Leu Glu Lys Lys Pro Asp Glu Phe Gln Lys Gln Val Phe Asp Pro Leu 
        515                 520                 525             


Lys Gly Asn Ile Asp Leu Ser Asp Ser Lys Ser Ser Thr Leu Leu Lys 
    530                 535                 540                 


Phe Val Thr Pro Leu Leu Thr Pro Gly Glu Glu Ile Arg Glu Arg Arg 
545                 550                 555                 560 


Gln Ser Gly Lys Tyr Glu Tyr Ile Thr Glu Leu Leu Val Lys Gly Val 
                565                 570                 575     


Asp Lys Trp Thr Val Lys Gly Val Gln Asp Lys Gly Ala Val Tyr Asp 
            580                 585                 590         


Tyr Ser Asn Leu Ile Gln His Ala Ser Val Gly Asn Asn Gln Tyr Arg 
        595                 600                 605             


Glu Ile Arg Ile Glu Ser His Leu Gly Asp Gly Asp Asp Lys Val Phe 
    610                 615                 620                 


Leu Ser Ala Gly Ser Ala Asn Ile Tyr Ala Gly Lys Gly His Asp Val 
625                 630                 635                 640 


Val Tyr Tyr Asp Lys Thr Asp Thr Gly Tyr Leu Thr Ile Asp Gly Thr 
                645                 650                 655     


Lys Ala Thr Glu Ala Gly Asn Tyr Thr Val Thr Arg Val Leu Gly Gly 
            660                 665                 670         


Asp Val Lys Val Leu Gln Glu Val Val Lys Glu Gln Glu Val Ser Val 
        675                 680                 685             


Gly Lys Arg Thr Glu Lys Thr Gln Tyr Arg Ser Tyr Glu Phe Thr His 
    690                 695                 700                 


Ile Asn Gly Lys Asn Leu Thr Glu Thr Asp Asn Leu Tyr Ser Val Glu 
705                 710                 715                 720 


Glu Leu Ile Gly Thr Thr Arg Ala Asp Lys Phe Phe Gly Ser Lys Phe 
                725                 730                 735     


Thr Asp Ile Phe His Gly Ala Asp Gly Asp Asp Leu Ile Glu Gly Asn 
            740                 745                 750         


Asp Gly Asn Asp Arg Leu Tyr Gly Asp Lys Gly Asn Asp Thr Leu Ser 
        755                 760                 765             


Gly Gly Asn Gly Asp Asp Gln Leu Tyr Gly Gly Asp Gly Asn Asp Lys 
    770                 775                 780                 


Leu Ile Gly Gly Ala Gly Asn Asn Tyr Leu Asn Gly Gly Asp Gly Asp 
785                 790                 795                 800 


Asp Glu Leu Gln Val Gln Gly Asn Ser Leu Ala Lys Asn Val Leu Phe 
                805                 810                 815     


Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu 
            820                 825                 830         


Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn 
        835                 840                 845             


Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp 
    850                 855                 860                 


Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg 
865                 870                 875                 880 


Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala 
                885                 890                 895     


Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg 
            900                 905                 910         


Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu 
        915                 920                 925             


Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys 
    930                 935                 940                 


Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr 
945                 950                 955                 960 


Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu 
                965                 970                 975     


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val 
            980                 985                 990         


Lys Glu Glu Arg Thr Ala Ala Ser  Leu Leu Gln Leu Ser  Gly Asn Ala 
        995                 1000                 1005             


Ser Asp  Phe Ser Tyr Gly Arg  Asn Ser Ile Thr Leu  Thr Thr Ser 
    1010                 1015                 1020             


Ala 
    


<210>  42
<211>  42
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  42

Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
1               5                   10                  15      


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
            20                  25                  30          


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn 
        35                  40          


<210>  43
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  43

Thr Thr Ile Thr Thr Ala Gln Ile Lys Ser Thr Leu Gln Ser Ala Lys 
1               5                   10                  15      


Gln Ser Ala Ala Asn Lys Leu His Ser Ala Gly Gln Ser Thr Lys Asp 
            20                  25                  30          


Ala Leu Lys Lys Ala Ala Glu Gln Thr Arg Asn Ala Gly Asn Arg Leu 
        35                  40                  45              


Ile Leu Leu Ile Pro Lys Asp Tyr Lys Gly Gln Gly Ser Ser Leu Asn 
    50                  55                  60                  


Asp Leu Val Arg Thr Ala Asp Glu Leu Gly Ile Glu Val Gln Tyr Asp 
65                  70                  75                  80  


Glu Lys Asn Gly Thr Ala Ile Thr Lys Gln Val Phe Gly Thr Ala Glu 
                85                  90                  95      


Lys Leu Ile Gly Leu Thr Glu Arg Gly Val Thr Ile Phe Ala Pro Gln 
            100                 105                 110         


Leu Asp Lys Leu Leu Gln Lys Tyr Gln Lys Ala Gly Asn Ile Leu Gly 
        115                 120                 125             


Gly Gly Ala Glu Asn Ile Gly Asp Asn Leu Gly Lys Ala Gly Gly Ile 
    130                 135                 140                 


Leu Ser Thr Phe Gln Asn Phe Leu Gly Thr Ala Leu Ser Ser Met Lys 
145                 150                 155                 160 


Ile Asp Glu Leu Ile Lys Lys Gln Lys Ser Gly Gly Asn Val Ser Ser 
                165                 170                 175     


Ser Glu Met Ala Glu Ala Ser Ile Glu Leu Ile Asn Gln Leu Val Asp 
            180                 185                 190         


Thr Val Ala Ser Leu Asn Asn Asn Val Asn Ser Phe Ser Gln Gln Leu 
        195                 200                 205             


Asn Thr Leu Gly Ser Val Leu Ser Asn Thr Lys His Leu Asn Gly Val 
    210                 215                 220                 


Gly Asn Lys Leu Gln Asn Leu Pro Asn Leu Asp Asn Ile Gly Ala Gly 
225                 230                 235                 240 


Leu Asp Thr Val Ser Gly Ile Leu Ser Ala Ile Ser Ala Ser Phe Ile 
                245                 250                 255     


Leu Ser Asn Ala Asp Ala Asp Thr Arg Thr Lys Ala Ala Ala Gly Val 
            260                 265                 270         


Glu Leu Thr Thr Lys Val Leu Gly Asn Val Gly Lys Gly Ile Ser Gln 
        275                 280                 285             


Tyr Ile Ile Ala Gln Arg Ala Ala Gln Gly Leu Ser Thr Ser Ala Ala 
    290                 295                 300                 


Ala Ala Gly Leu Ile Ala Ser Ala Val Thr Leu Ala Ile Ser Pro Leu 
305                 310                 315                 320 


Ser Phe Leu Ser Ile Ala Asp Lys Phe Lys Arg Ala Asn Lys Ile Glu 
                325                 330                 335     


Glu Tyr Ser Gln Arg Phe Lys Lys Leu Gly Tyr Asp Gly Asp Ser Leu 
            340                 345                 350         


Leu Ala Ala Phe His Lys Glu Thr Gly Ala Ile Asp Ala Ser Leu Thr 
        355                 360                 365             


Thr Ile Ser Thr Val Leu Ala Ser Val Ser Ser Gly Ile Ser Ala Ala 
    370                 375                 380                 


Ala Thr Thr Ser Leu Val Gly Ala Pro Val Ser Ala Leu Val Gly Ala 
385                 390                 395                 400 


Val Thr Gly Ile Ile Ser Gly Ile Leu Glu Ala Ser Lys Gln Ala Met 
                405                 410                 415     


Phe Glu His Val Ala Ser Lys Met Ala Asp Val Ile Ala Glu Trp Glu 
            420                 425                 430         


Lys Lys His Gly Lys Asn Tyr Phe Glu Asn Gly Tyr Asp Ala Arg His 
        435                 440                 445             


Ala Ala Phe Leu Glu Asp Asn Phe Lys Ile Leu Ser Gln Tyr Asn Lys 
    450                 455                 460                 


Glu Tyr Ser Val Glu Arg Ser Val Leu Ile Thr Gln Gln His Trp Asp 
465                 470                 475                 480 


Thr Leu Ile Gly Glu Leu Ala Gly Val Thr Arg Asn Gly Asp Lys Thr 
                485                 490                 495     


Leu Ser Gly Lys Ser Tyr Ile Asp Tyr Tyr Glu Glu Gly Lys Arg Leu 
            500                 505                 510         


Glu Lys Lys Pro Asp Glu Phe Gln Lys Gln Val Phe Asp Pro Leu Lys 
        515                 520                 525             


Gly Asn Ile Asp Leu Ser Asp Ser Lys Ser Ser Thr Leu Leu Lys Phe 
    530                 535                 540                 


Val Thr Pro Leu Leu Thr Pro Gly Glu Glu Ile Arg Glu Arg Arg Gln 
545                 550                 555                 560 


Ser Gly Lys Tyr Glu Tyr Ile Thr Glu Leu Leu Val Lys Gly Val Asp 
                565                 570                 575     


Lys Trp Thr Val Lys Gly Val Gln Asp Lys Gly Ala Val Tyr Asp Tyr 
            580                 585                 590         


Ser Asn Leu Ile Gln His Ala Ser Val Gly Asn Asn Gln Tyr Arg Glu 
        595                 600                 605             


Ile Arg Ile Glu Ser His Leu Gly Asp Gly Asp Asp Lys Val Phe Leu 
    610                 615                 620                 


Ser Ala Gly Ser Ala Asn Ile Tyr Ala Gly Lys Gly His Asp Val Val 
625                 630                 635                 640 


Tyr Tyr Asp Lys Thr Asp Thr Gly Tyr Leu Thr Ile Asp Gly Thr Lys 
                645                 650                 655     


Ala Thr Glu Ala Gly Asn Tyr Thr Val Thr Arg Val Leu Gly Gly Asp 
            660                 665                 670         


Val Lys Val Leu Gln Glu Val Val Lys Glu Gln Glu Val Ser Val Gly 
        675                 680                 685             


Lys Arg Thr Glu Lys Thr Gln Tyr Arg Ser Tyr Glu Phe Thr His Ile 
    690                 695                 700                 


Asn Gly Lys Asn Leu Thr Glu Thr Asp Asn Leu Tyr Ser Val Glu Glu 
705                 710                 715                 720 


Leu Ile Gly Thr Thr Arg Ala Asp Lys Phe Phe Gly Ser Lys Phe Thr 
                725                 730                 735     


Asp Ile Phe His Gly Ala Asp Gly Asp Asp Leu Ile Glu Gly Asn Asp 
            740                 745                 750         


Gly Asn Asp Arg Leu Tyr Gly Asp Lys Gly Asn Asp Thr Leu Ser Gly 
        755                 760                 765             


Gly Asn Gly Asp Asp Gln Leu Tyr Gly Gly Asp Gly Asn Asp Lys Leu 
    770                 775                 780                 


Ile Gly Gly Ala Gly Asn Asn Tyr Leu Asn Gly Gly Asp Gly Asp Asp 
785                 790                 795                 800 


Glu Leu Gln Val Gln Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly 
                805                 810                 815     


Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu 
            820                 825                 830         


Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp 
        835                 840                 845             


Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp 
    850                 855                 860                 


Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp 
865                 870                 875                 880 


Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu 
                885                 890                 895     


Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn 
            900                 905                 910         


Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln 
        915                 920                 925             


Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys 
    930                 935                 940                 


Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly 
945                 950                 955                 960 


Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile 
                965                 970                 975     


Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys 
            980                 985                 990         


Glu Glu Arg Thr Ala Ala Ser Leu  Leu Gln Leu Ser Gly  Asn Ala Ser 
        995                 1000                 1005             


Asp Phe  Ser Tyr Gly Arg Asn  Ser Ile Thr Leu Thr  Thr Ser Ala 
    1010                 1015                 1020             


<210>  44
<211>  284
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  44

His Gly Ala Asp Gly Asp Asp Leu Ile Glu Gly Asn Asp Gly Asn Asp 
1               5                   10                  15      


Arg Leu Tyr Gly Asp Lys Gly Asn Asp Thr Leu Ser Gly Gly Asn Gly 
            20                  25                  30          


Asp Asp Gln Leu Tyr Gly Gly Asp Gly Asn Asp Lys Leu Ile Gly Gly 
        35                  40                  45              


Ala Gly Asn Asn Tyr Leu Asn Gly Gly Asp Gly Asp Asp Glu Leu Gln 
    50                  55                  60                  


Val Gln Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly 
65                  70                  75                  80  


Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly 
                85                  90                  95      


Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg 
            100                 105                 110         


Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys 
        115                 120                 125             


Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe 
    130                 135                 140                 


Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val 
145                 150                 155                 160 


Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu 
                165                 170                 175     


Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp 
            180                 185                 190         


Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu 
        195                 200                 205             


Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala 
    210                 215                 220                 


Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile 
225                 230                 235                 240 


Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg 
                245                 250                 255     


Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser 
            260                 265                 270         


Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
        275                 280                 


<210>  45
<211>  236
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  45

Ala Gly Asn Asn Tyr Leu Asn Gly Gly Asp Gly Asp Asp Glu Leu Gln 
1               5                   10                  15      


Val Gln Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly 
            20                  25                  30          


Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly 
        35                  40                  45              


Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg 
    50                  55                  60                  


Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys 
65                  70                  75                  80  


Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe 
                85                  90                  95      


Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val 
            100                 105                 110         


Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu 
        115                 120                 125             


Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp 
    130                 135                 140                 


Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu 
145                 150                 155                 160 


Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala 
                165                 170                 175     


Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile 
            180                 185                 190         


Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg 
        195                 200                 205             


Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser 
    210                 215                 220                 


Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
225                 230                 235     


<210>  46
<211>  218
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  46

Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp 
1               5                   10                  15      


Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly 
            20                  25                  30          


Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu 
        35                  40                  45              


Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp 
    50                  55                  60                  


Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg 
65                  70                  75                  80  


Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser 
                85                  90                  95      


Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu 
            100                 105                 110         


Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser 
        115                 120                 125             


Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln 
    130                 135                 140                 


Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala 
145                 150                 155                 160 


Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys 
                165                 170                 175     


Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala 
            180                 185                 190         


Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly 
        195                 200                 205             


Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
    210                 215             


<210>  47
<211>  200
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  47

Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp 
1               5                   10                  15      


Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly 
            20                  25                  30          


Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu 
        35                  40                  45              


Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly 
    50                  55                  60                  


Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly 
65                  70                  75                  80  


His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly 
                85                  90                  95      


Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg 
            100                 105                 110         


Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg 
        115                 120                 125             


Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly 
    130                 135                 140                 


Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile 
145                 150                 155                 160 


Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser 
                165                 170                 175     


Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn 
            180                 185                 190         


Ser Ile Thr Leu Thr Thr Ser Ala 
        195                 200 


<210>  48
<211>  183
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  48

Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr 
1               5                   10                  15      


Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser 
            20                  25                  30          


Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn 
        35                  40                  45              


Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His 
    50                  55                  60                  


Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp 
65                  70                  75                  80  


Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile 
                85                  90                  95      


Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn 
            100                 105                 110         


Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser 
        115                 120                 125             


Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser 
    130                 135                 140                 


Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu 
145                 150                 155                 160 


Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser 
                165                 170                 175     


Ile Thr Leu Thr Thr Ser Ala 
            180             


<210>  49
<211>  164
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  49

Met Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp 
1               5                   10                  15      


Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile 
            20                  25                  30          


Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly 
        35                  40                  45              


Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn 
    50                  55                  60                  


His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro 
65                  70                  75                  80  


Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala 
                85                  90                  95      


Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp 
            100                 105                 110         


Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
        115                 120                 125             


Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu 
    130                 135                 140                 


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
145                 150                 155                 160 


Thr Thr Ser Ala 
                


<210>  50
<211>  150
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  50

Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp 
1               5                   10                  15      


Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys 
            20                  25                  30          


Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile 
        35                  40                  45              


Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile 
    50                  55                  60                  


Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn 
65                  70                  75                  80  


Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln 
                85                  90                  95      


Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
            100                 105                 110         


Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu 
        115                 120                 125             


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
    130                 135                 140                 


Thr Leu Thr Thr Ser Ala 
145                 150 


<210>  51
<211>  60
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  51

Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile 
1               5                   10                  15      


Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg 
            20                  25                  30          


Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser 
        35                  40                  45              


Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
    50                  55                  60  


<210>  52
<211>  50
<212>  PRT
<213>  Artificial

<220>
<223>  fragment of HlyA

<400>  52

Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
1               5                   10                  15      


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
            20                  25                  30          


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
        35                  40                  45              


Ser Ala 
    50  


<210>  53
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  53
tatattaatt taaatgatag caatcttact g                                      31


<210>  54
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  54
ttaattacct cttaaccagt taatg                                             25


<210>  55
<211>  40
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  55
ttaagaggta attaaatggg aaattctctt gcaaaaaatg                             40


<210>  56
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  56
atttaaatta atatattatg ctgatgtggt cag                                    33


<210>  57
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  57
ggaaattctc ttgcaaaaaa tgtatta                                           27


<210>  58
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  58
catttaatta cctcttaacc agttaatg                                          28


<210>  59
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  59
agaggtaatt aaatgtgtga tctgccgcag actc                                   34


<210>  60
<211>  46
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  60
tgcaagagaa tttccttcct tacttcttaa actttcttgc aagttt                      46


<210>  61
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  61
tgcaagagaa tttccacggc catcaatttc cttacttctt aaactttctt gcaagttt         58


<210>  62
<211>  6960
<212>  DNA
<213>  Artificial

<220>
<223>  pSU vector including HlyA full length

<400>  62
tgattacgaa ttcgagctcc caaaactcat gttggtaaag tatcagaatt tcatggaggt       60

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      120

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatga      180

caacaataac cactgcacaa attaaaagca cactgcagtc tgcaaagcaa tccgctgcaa      240

ataaattgca ctcagcagga caaagcacga aagatgcatt aaaaaaagca gcagagcaaa      300

cccgcaatgc gggaaacaga ctcattttac ttatccctaa agattataaa ggacagggtt      360

caagccttaa tgaccttgtc aggacggcag atgaactggg aattgaagtc cagtatgatg      420

aaaagaatgg cacggcgatt actaaacagg tgttcggcac agcagagaaa ctcattggcc      480

tcaccgaacg gggagtgact atctttgcac cacaattaga caaattactg caaaagtatc      540

aaaaagcagg taatatatta ggtggcggtg ctgaaaatat cggtgataac ttaggaaagg      600

caggcggtat attgtcaacg tttcaaaatt tcctgggtac tgcactttcc tcaatgaaaa      660

tagacgaact gataaagaaa caaaaatctg gtggcaatgt cagttcttct gagatggcag      720

aagcgagtat tgagctaatc aatcaacttg tggatacagt tgccagcctt aataataatg      780

ttaactcatt ttctcaacaa ctcaatactc tgggaagtgt attatccaat acaaagcacc      840

tgaacggtgt tggtaataag ttacagaatt tacctaatct tgataatatc ggtgcagggt      900

tagatactgt atcgggtatt ttatctgcga tttcagcaag cttcattctg agcaatgcag      960

atgcagatac cagaactaaa gctgcagcag gtgttgaatt aacaacgaaa gtactgggta     1020

atgttggaaa aggtatttct caatatatta tcgcacagcg cgctgcacag gggttatcta     1080

catctgctgc tgctgccggt ttaattgctt ctgctgtgac actagcaatt agtcccctct     1140

cattcctgtc cattgccgat aagtttaaac gtgccaataa aatagaggag tattcacaac     1200

gattcaaaaa acttggatac gatggtgaca gtttacttgc tgctttccac aaagaaacag     1260

gggctattga tgcatcatta acaacgataa gcactgtact ggcttcagta tcttcaggta     1320

ttagtgctgc tgcaacgaca tctctggttg gtgcaccggt aagcgcgctg gtaggcgctg     1380

ttacggggat aatttcaggt atccttgagg cttcaaagca ggcaatgttt gaacatgttg     1440

ccagtaaaat ggctgatgtt attgctgaat gggagaaaaa acacggcaaa aattactttg     1500

aaaatggata tgatgcccgc catgctgcat ttttagaaga taactttaaa atattatctc     1560

agtataataa agagtattct gttgaaagat cagtcctcat tacccagcaa cattgggata     1620

cgctgatagg tgagttagct ggtgtcacca gaaatggaga caaaacactc agtggtaaaa     1680

gttatattga ctattatgaa gaaggaaaac gtctggagaa aaaaccggat gaattccaga     1740

agcaagtctt tgacccattg aaaggaaata ttgacctttc tgacagcaaa tcttctacgt     1800

tattgaaatt tgttacgcca ttattaactc ccggtgagga aattcgtgaa aggaggcagt     1860

ccggaaaata tgaatatatt accgagttat tagtcaaggg tgttgataaa tggacggtga     1920

agggggttca ggacaagggg gctgtatatg attactctaa cctgattcag catgcatcag     1980

tcggtaataa ccagtatcgg gaaatccgta ttgagtcaca cctgggagac ggggatgata     2040

aggtcttttt atctgccggc tcagccaata tctacgcagg taaaggacat gatgttgttt     2100

attatgataa aacagacact ggttatctga ccattgatgg cacaaaagca accgaagcgg     2160

gtaattacac ggtaacacgt gtacttggtg gcgatgttaa ggttttacag gaagttgtga     2220

aggagcagga ggtttcagtc ggaaaaagaa ctgaaaaaac gcaatatcgg agttatgaat     2280

tcactcatat caatggtaaa aatttaacag agactgataa cttatattcc gtggaagaac     2340

ttattgggac cacgcgtgcc gacaagtttt ttggcagtaa atttactgat atcttccatg     2400

gcgcggatgg tgatgacctt atagaaggaa atgatgggaa tgaccgctta tatggtgata     2460

aaggtaatga cacactgagt ggtggaaacg gagatgacca gctctatggc ggtgatggta     2520

acgataagtt gattggggga gcaggtaata attacctgaa cggcggagat ggagatgatg     2580

agcttcaggt tcagggaaat tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg     2640

acaagctgta cggcagtgag ggggcagatc tgcttgatgg tggagagggg gatgatctcc     2700

tgaaaggcgg atatggtaat gatatttatc gttatctgtc aggatatggt catcatatta     2760

ttgatgatga tggggggaaa gaggataaac tcagtttggc tgatattgat ttccgggatg     2820

tggccttcaa gcgagaaggt aatgacctca tcatgtataa agctgaaggt aatgttcttt     2880

ccattggtca taaaaatggt attacattca ggaactggtt tgaaaaagag tcaggtgata     2940

tctctaatca ccagatagag cagatttttg ataaaagtgg ccggataatc acacctgatt     3000

cccttaaaaa ggcacttgag tatcaacagc gtaataataa ggcaagttat gtgtatggga     3060

atgatgcatt agcctatgga agtcagggtg atcttaatcc attaattaat gaaatcagca     3120

aaatcatttc agctgcaggt agcttcgatg ttaaagagga aagaactgca gcttctttat     3180

tgcagttgtc cggtaatgcc agtgattttt catatggacg gaactcaata accctgacca     3240

catcagcata atatattaat ttaaatgata gcaatcttac tgggctgtgc cacataagat     3300

tgctattttt tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc     3360

cctggagatt ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag     3420

atttgataca gacgggacag gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt     3480

agaactaaag gtaaaacagg taaaaaaaac aattgatcga tgataagctg tcaaacatga     3540

gaattacaac ttatatcgta tggggctgac ttcaggtgct acatttgaag agataaattg     3600

cactgaaatc ctgcaggcat gcaagcttgg cactggccgt cgttttacaa cgtcgtgact     3660

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     3720

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg     3780

gcgaatgccg ttaacggatt cttgaagacg aaagggcctc gtgatacgcc tatttttata     3840

ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt     3900

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     3960

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     4020

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     4080

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     4140

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     4200

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     4260

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     4320

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     4380

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     4440

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     4500

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     4560

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     4620

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     4680

tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc     4740

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     4800

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     4860

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     4920

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     4980

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     5040

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     5100

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     5160

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     5220

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     5280

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     5340

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     5400

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     5460

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     5520

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     5580

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     5640

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt     5700

atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg     5760

cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg     5820

gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac     5880

aatctgctct gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg     5940

gtcatggctg cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg     6000

ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg     6060

ttttcaccgt catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg     6120

tgaagcgatt cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga     6180

agcgttaatg tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg     6240

gtcactgatg cctccgtgta agggggattt ctgttcatgg gggtaatgat accgatgaaa     6300

cgagagagga tgctcacgat acgggttact gatgatgaac atgcccggtt actggaacgt     6360

tgtgagggta aacaactggc ggtatggatg cggcgggacc agagaaaaat cactcagggt     6420

caatgccagc gcttcgttaa tacagatgta ggtgttccac agggtagcca gcagcatcct     6480

gcgatgcaga tccggaacat aatggtgcag ggcgctgact tccgcgtttc cagactttac     6540

gaaacacgga aaccgaagac cattcatgtt gttgctcagg tcgcagacgt tttgcagcag     6600

cagtcgcttc acgttcgctc gcgtatcggt gattcattct gctaaccagt aaggcaaccc     6660

cgccagccta gccgggtcct caacgacagg agcacgatca tgcgcacccg tggccaggac     6720

ccaacgctgc ccgccgttaa cggccaatac gcaaaccgcc tctccccgcg cgttggccga     6780

ttcattaatg cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg     6840

caattaatgt gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg     6900

ctcgtatgtt gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgaca     6960


<210>  63
<211>  4545
<212>  DNA
<213>  Artificial

<220>
<223>  pSU vector including HlyC fragment + gap + HlyA1

<400>  63
tgattacgaa ttcgagctcc caaaactcat gttggtaaag tatcagaatt tcatggaggt       60

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      120

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatgg      180

gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag ctgtacggca      240

gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa ggcggatatg      300

gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat gatgatgggg      360

ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc ttcaagcgag      420

aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt ggtcataaaa      480

atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct aatcaccaga      540

tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt aaaaaggcac      600

ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat gcattagcct      660

atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc atttcagctg      720

caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag ttgtccggta      780

atgccagtga tttttcatat ggacggaact caataaccct gaccacatca gcataatata      840

ttaatttaaa tgatagcaat cttactgggc tgtgccacat aagattgcta ttttttttgg      900

agtcataatg gattcttgtc ataaaattga ttatgggtta tacgccctgg agattttagc      960

ccaataccat aacgtctctg ttaacccgga agaaattaaa catagatttg atacagacgg     1020

gacaggtctg ggattaacgt catggttgct tgctgcgaaa tctttagaac taaaggtaaa     1080

acaggtaaaa aaaacaattg atcgatgata agctgtcaaa catgagaatt acaacttata     1140

tcgtatgggg ctgacttcag gtgctacatt tgaagagata aattgcactg aaatcctgca     1200

ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     1260

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     1320

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgccgttaac     1380

ggattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1440

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1500

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1560

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1620

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1680

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     1740

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     1800

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     1860

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     1920

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     1980

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2040

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2100

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2160

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2220

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2280

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     2340

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2400

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2460

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2520

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2580

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2640

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     2700

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     2760

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     2820

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     2880

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     2940

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3000

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3060

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3120

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3180

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3240

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     3300

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     3360

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     3420

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3480

cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc     3540

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     3600

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     3660

ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag     3720

atgtctgcct gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg     3780

cttctgataa agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc     3840

gtgtaagggg gatttctgtt catgggggta atgataccga tgaaacgaga gaggatgctc     3900

acgatacggg ttactgatga tgaacatgcc cggttactgg aacgttgtga gggtaaacaa     3960

ctggcggtat ggatgcggcg ggaccagaga aaaatcactc agggtcaatg ccagcgcttc     4020

gttaatacag atgtaggtgt tccacagggt agccagcagc atcctgcgat gcagatccgg     4080

aacataatgg tgcagggcgc tgacttccgc gtttccagac tttacgaaac acggaaaccg     4140

aagaccattc atgttgttgc tcaggtcgca gacgttttgc agcagcagtc gcttcacgtt     4200

cgctcgcgta tcggtgattc attctgctaa ccagtaaggc aaccccgcca gcctagccgg     4260

gtcctcaacg acaggagcac gatcatgcgc acccgtggcc aggacccaac gctgcccgcc     4320

gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4380

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     4440

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     4500

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaca                     4545


<210>  64
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  64
agaggtaatt aaatgctacc ttccggttcg                                        30


<210>  65
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  65
tgcaagagaa tttccggggg tgacgatg                                          28


<210>  66
<211>  1770
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  66
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgctaccttc cggttcggac      180

cctgcctttt cgcagcccaa gtcggtgctc gatgcgggtc tgacctgcca gggtgcttcg      240

ccatcctcgg tctccaaacc catccttctc gtccccggaa ccggcaccac aggtccacag      300

tcgttcgact cgaactggat ccccctctct gcgcagctgg gttacacacc ctgctggatc      360

tcacccccgc cgttcatgct caacgacacc caggtcaaca cggagtacat ggtcaacgcc      420

atcaccacgc tctacgctgg ttcgggcaac aacaagcttc ccgtgctcac ctggtcccag      480

ggtggtctgg ttgcacagtg gggtctgacc ttcttcccca gtatcaggtc caaggtcgat      540

cgacttatgg cctttgcgcc cgactacaag ggcaccgtcc tcgccggccc tctcgatgca      600

ctcgcggtta gtgcaccctc cgtatggcag caaaccaccg gttcggcact cactaccgca      660

ctccgaaacg caggtggtct gacccagatc gtgcccacca ccaacctcta ctcggcgacc      720

gacgagatcg ttcagcctca ggtgtccaac tcgccactcg actcatccta cctcttcaac      780

ggaaagaacg tccaggcaca ggctgtgtgt gggccgctgt tcgtcatcga ccatgcaggc      840

tcgctcacct cgcagttctc ctacgtcgtc ggtcgatccg ccctgcgctc caccacgggc      900

caggctcgta gtgcagacta tggcattacg gactgcaacc ctcttcccgc caatgatctg      960

actcccgagc aaaaggtcgc cgcggctgcg ctcctggcgc cggcggctgc agccatcgtg     1020

gcgggtccaa agcagaactg cgagcccgac ctcatgccct acgcccgccc ctttgcagta     1080

ggcaaaagga cctgctccgg catcgtcacc cccggaaatt ctcttgcaaa aaatgtatta     1140

ttcggtggaa aaggtaatga caagctgtac ggcagtgagg gggcagatct gcttgatggt     1200

ggagaggggg atgatctcct gaaaggcgga tatggtaatg atatttatcg ttatctgtca     1260

ggatatggtc atcatattat tgatgatgat ggggggaaag aggataaact cagtttggct     1320

gatattgatt tccgggatgt ggccttcaag cgagaaggta atgacctcat catgtataaa     1380

gctgaaggta atgttctttc cattggtcat aaaaatggta ttacattcag gaactggttt     1440

gaaaaagagt caggtgatat ctctaatcac cagatagagc agatttttga taaaagtggc     1500

cggataatca cacctgattc ccttaaaaag gcacttgagt atcaacagcg taataataag     1560

gcaagttatg tgtatgggaa tgatgcatta gcctatggaa gtcagggtga tcttaatcca     1620

ttaattaatg aaatcagcaa aatcatttca gctgcaggta gcttcgatgt taaagaggaa     1680

agaactgcag cttctttatt gcagttgtcc ggtaatgcca gtgatttttc atatggacgg     1740

aactcaataa ccctgaccac atcagcataa                                      1770


<210>  67
<211>  1611
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  67
atgctacctt ccggttcgga ccctgccttt tcgcagccca agtcggtgct cgatgcgggt       60

ctgacctgcc agggtgcttc gccatcctcg gtctccaaac ccatccttct cgtccccgga      120

accggcacca caggtccaca gtcgttcgac tcgaactgga tccccctctc tgcgcagctg      180

ggttacacac cctgctggat ctcacccccg ccgttcatgc tcaacgacac ccaggtcaac      240

acggagtaca tggtcaacgc catcaccacg ctctacgctg gttcgggcaa caacaagctt      300

cccgtgctca cctggtccca gggtggtctg gttgcacagt ggggtctgac cttcttcccc      360

agtatcaggt ccaaggtcga tcgacttatg gcctttgcgc ccgactacaa gggcaccgtc      420

ctcgccggcc ctctcgatgc actcgcggtt agtgcaccct ccgtatggca gcaaaccacc      480

ggttcggcac tcactaccgc actccgaaac gcaggtggtc tgacccagat cgtgcccacc      540

accaacctct actcggcgac cgacgagatc gttcagcctc aggtgtccaa ctcgccactc      600

gactcatcct acctcttcaa cggaaagaac gtccaggcac aggctgtgtg tgggccgctg      660

ttcgtcatcg accatgcagg ctcgctcacc tcgcagttct cctacgtcgt cggtcgatcc      720

gccctgcgct ccaccacggg ccaggctcgt agtgcagact atggcattac ggactgcaac      780

cctcttcccg ccaatgatct gactcccgag caaaaggtcg ccgcggctgc gctcctggcg      840

ccggcggctg cagccatcgt ggcgggtcca aagcagaact gcgagcccga cctcatgccc      900

tacgcccgcc cctttgcagt aggcaaaagg acctgctccg gcatcgtcac ccccggaaat      960

tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta cggcagtgag     1020

ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg atatggtaat     1080

gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga tggggggaaa     1140

gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa gcgagaaggt     1200

aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca taaaaatggt     1260

attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca ccagatagag     1320

cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa ggcacttgag     1380

tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt agcctatgga     1440

agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc agctgcaggt     1500

agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc cggtaatgcc     1560

agtgattttt catatggacg gaactcaata accctgacca catcagcata a              1611


<210>  68
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  68

Met Leu Pro Ser Gly Ser Asp Pro Ala Phe Ser Gln Pro Lys Ser Val 
1               5                   10                  15      


Leu Asp Ala Gly Leu Thr Cys Gln Gly Ala Ser Pro Ser Ser Val Ser 
            20                  25                  30          


Lys Pro Ile Leu Leu Val Pro Gly Thr Gly Thr Thr Gly Pro Gln Ser 
        35                  40                  45              


Phe Asp Ser Asn Trp Ile Pro Leu Ser Ala Gln Leu Gly Tyr Thr Pro 
    50                  55                  60                  


Cys Trp Ile Ser Pro Pro Pro Phe Met Leu Asn Asp Thr Gln Val Asn 
65                  70                  75                  80  


Thr Glu Tyr Met Val Asn Ala Ile Thr Thr Leu Tyr Ala Gly Ser Gly 
                85                  90                  95      


Asn Asn Lys Leu Pro Val Leu Thr Trp Ser Gln Gly Gly Leu Val Ala 
            100                 105                 110         


Gln Trp Gly Leu Thr Phe Phe Pro Ser Ile Arg Ser Lys Val Asp Arg 
        115                 120                 125             


Leu Met Ala Phe Ala Pro Asp Tyr Lys Gly Thr Val Leu Ala Gly Pro 
    130                 135                 140                 


Leu Asp Ala Leu Ala Val Ser Ala Pro Ser Val Trp Gln Gln Thr Thr 
145                 150                 155                 160 


Gly Ser Ala Leu Thr Thr Ala Leu Arg Asn Ala Gly Gly Leu Thr Gln 
                165                 170                 175     


Ile Val Pro Thr Thr Asn Leu Tyr Ser Ala Thr Asp Glu Ile Val Gln 
            180                 185                 190         


Pro Gln Val Ser Asn Ser Pro Leu Asp Ser Ser Tyr Leu Phe Asn Gly 
        195                 200                 205             


Lys Asn Val Gln Ala Gln Ala Val Cys Gly Pro Leu Phe Val Ile Asp 
    210                 215                 220                 


His Ala Gly Ser Leu Thr Ser Gln Phe Ser Tyr Val Val Gly Arg Ser 
225                 230                 235                 240 


Ala Leu Arg Ser Thr Thr Gly Gln Ala Arg Ser Ala Asp Tyr Gly Ile 
                245                 250                 255     


Thr Asp Cys Asn Pro Leu Pro Ala Asn Asp Leu Thr Pro Glu Gln Lys 
            260                 265                 270         


Val Ala Ala Ala Ala Leu Leu Ala Pro Ala Ala Ala Ala Ile Val Ala 
        275                 280                 285             


Gly Pro Lys Gln Asn Cys Glu Pro Asp Leu Met Pro Tyr Ala Arg Pro 
    290                 295                 300                 


Phe Ala Val Gly Lys Arg Thr Cys Ser Gly Ile Val Thr Pro Gly Asn 
305                 310                 315                 320 


Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu 
                325                 330                 335     


Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp 
            340                 345                 350         


Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly 
        355                 360                 365             


Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu 
    370                 375                 380                 


Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly 
385                 390                 395                 400 


Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly 
                405                 410                 415     


His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly 
            420                 425                 430         


Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg 
        435                 440                 445             


Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg 
    450                 455                 460                 


Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly 
465                 470                 475                 480 


Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile 
                485                 490                 495     


Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser 
            500                 505                 510         


Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn 
        515                 520                 525             


Ser Ile Thr Leu Thr Thr Ser Ala 
    530                 535     


<210>  69
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  69
agaggtaatt aaatggatgc ggaatttcgc catgatag                               38


<210>  70
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  70
tgcaagagaa tttcccacca cgccgcccac                                        30


<210>  71
<211>  939
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  71
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggatgcgga atttcgccat      180

gatagcggct atgaagtgca tcatcagaaa ctggtgtttt ttgcggaaga tgtgggcagc      240

aacaaaggcg cgattattgg cctgatggtg ggcggcgtgg tgggaaattc tcttgcaaaa      300

aatgtattat tcggtggaaa aggtaatgac aagctgtacg gcagtgaggg ggcagatctg      360

cttgatggtg gagaggggga tgatctcctg aaaggcggat atggtaatga tatttatcgt      420

tatctgtcag gatatggtca tcatattatt gatgatgatg gggggaaaga ggataaactc      480

agtttggctg atattgattt ccgggatgtg gccttcaagc gagaaggtaa tgacctcatc      540

atgtataaag ctgaaggtaa tgttctttcc attggtcata aaaatggtat tacattcagg      600

aactggtttg aaaaagagtc aggtgatatc tctaatcacc agatagagca gatttttgat      660

aaaagtggcc ggataatcac acctgattcc cttaaaaagg cacttgagta tcaacagcgt      720

aataataagg caagttatgt gtatgggaat gatgcattag cctatggaag tcagggtgat      780

cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtag cttcgatgtt      840

aaagaggaaa gaactgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      900

tatggacgga actcaataac cctgaccaca tcagcataa                             939


<210>  72
<211>  780
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  72
atggatgcgg aatttcgcca tgatagcggc tatgaagtgc atcatcagaa actggtgttt       60

tttgcggaag atgtgggcag caacaaaggc gcgattattg gcctgatggt gggcggcgtg      120

gtgggaaatt ctcttgcaaa aaatgtatta ttcggtggaa aaggtaatga caagctgtac      180

ggcagtgagg gggcagatct gcttgatggt ggagaggggg atgatctcct gaaaggcgga      240

tatggtaatg atatttatcg ttatctgtca ggatatggtc atcatattat tgatgatgat      300

ggggggaaag aggataaact cagtttggct gatattgatt tccgggatgt ggccttcaag      360

cgagaaggta atgacctcat catgtataaa gctgaaggta atgttctttc cattggtcat      420

aaaaatggta ttacattcag gaactggttt gaaaaagagt caggtgatat ctctaatcac      480

cagatagagc agatttttga taaaagtggc cggataatca cacctgattc ccttaaaaag      540

gcacttgagt atcaacagcg taataataag gcaagttatg tgtatgggaa tgatgcatta      600

gcctatggaa gtcagggtga tcttaatcca ttaattaatg aaatcagcaa aatcatttca      660

gctgcaggta gcttcgatgt taaagaggaa agaactgcag cttctttatt gcagttgtcc      720

ggtaatgcca gtgatttttc atatggacgg aactcaataa ccctgaccac atcagcataa      780


<210>  73
<211>  259
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  73

Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10                  15      


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
            20                  25                  30          


Ile Gly Leu Met Val Gly Gly Val Val Gly Asn Ser Leu Ala Lys Asn 
        35                  40                  45              


Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly 
    50                  55                  60                  


Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly 
65                  70                  75                  80  


Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile 
                85                  90                  95      


Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile 
            100                 105                 110         


Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met 
        115                 120                 125             


Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile 
    130                 135                 140                 


Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His 
145                 150                 155                 160 


Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp 
                165                 170                 175     


Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser 
            180                 185                 190         


Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu 
        195                 200                 205             


Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser 
    210                 215                 220                 


Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser 
225                 230                 235                 240 


Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr 
                245                 250                 255     


Thr Ser Ala 
            


<210>  74
<211>  945
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  74
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggatgcgga atttcgccat      180

gatagcggct atgaagtgca tcatcagaaa ctggtgtttt ttgcggaaga tgtgggcagc      240

aacaaaggcg cgattattgg cctgatggtg ggcggcgtgg tgatcgcggg aaattctctt      300

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      360

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      420

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      480

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      540

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca      600

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt      660

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa      720

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag      780

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc      840

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat      900

ttttcatatg gacggaactc aataaccctg accacatcag cataa                      945


<210>  75
<211>  786
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  75
atggatgcgg aatttcgcca tgatagcggc tatgaagtgc atcatcagaa actggtgttt       60

tttgcggaag atgtgggcag caacaaaggc gcgattattg gcctgatggt gggcggcgtg      120

gtgatcgcgg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag      180

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa      240

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat      300

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc      360

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt      420

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct      480

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt      540

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat      600

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc      660

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag      720

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca      780

gcataa                                                                 786


<210>  76
<211>  261
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  76

Met Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln 
1               5                   10                  15      


Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile 
            20                  25                  30          


Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Gly Asn Ser Leu Ala 
        35                  40                  45              


Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser 
    50                  55                  60                  


Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys 
65                  70                  75                  80  


Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His 
                85                  90                  95      


His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala 
            100                 105                 110         


Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu 
        115                 120                 125             


Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn 
    130                 135                 140                 


Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser 
145                 150                 155                 160 


Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr 
                165                 170                 175     


Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys 
            180                 185                 190         


Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly 
        195                 200                 205             


Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala 
    210                 215                 220                 


Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln 
225                 230                 235                 240 


Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr 
                245                 250                 255     


Leu Thr Thr Ser Ala 
            260     


<210>  77
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  77
agaggtaatt aaatgggcag cagccatcat catc                                   34


<210>  78
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  78
tgcaagagaa tttccgtcta ctttcggcgc ctgag                                  35


<210>  79
<211>  1032
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  79
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgggcagcag ccatcatcat      180

catcatcacc tgcaggtaga taacaaattc aacaaagaaa tggcgagtgc gggtggggag      240

atcgtttatt tacctaactt aaacccggat caactgtgcg ccttcatcca tagtttacat      300

gatgacccaa gccaaagcgc taacttgcta gcagaagcta aaaagctaaa tgatgctcag      360

gcgccgaaag tagacggaaa ttctcttgca aaaaatgtat tattcggtgg aaaaggtaat      420

gacaagctgt acggcagtga gggggcagat ctgcttgatg gtggagaggg ggatgatctc      480

ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg tcatcatatt      540

attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat      600

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt      660

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat      720

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat      780

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg      840

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc      900

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta      960

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc     1020

acatcagcat aa                                                         1032


<210>  80
<211>  873
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  80
atgggcagca gccatcatca tcatcatcac ctgcaggtag ataacaaatt caacaaagaa       60

atggcgagtg cgggtgggga gatcgtttat ttacctaact taaacccgga tcaactgtgc      120

gccttcatcc atagtttaca tgatgaccca agccaaagcg ctaacttgct agcagaagct      180

aaaaagctaa atgatgctca ggcgccgaaa gtagacggaa attctcttgc aaaaaatgta      240

ttattcggtg gaaaaggtaa tgacaagctg tacggcagtg agggggcaga tctgcttgat      300

ggtggagagg gggatgatct cctgaaaggc ggatatggta atgatattta tcgttatctg      360

tcaggatatg gtcatcatat tattgatgat gatgggggga aagaggataa actcagtttg      420

gctgatattg atttccggga tgtggccttc aagcgagaag gtaatgacct catcatgtat      480

aaagctgaag gtaatgttct ttccattggt cataaaaatg gtattacatt caggaactgg      540

tttgaaaaag agtcaggtga tatctctaat caccagatag agcagatttt tgataaaagt      600

ggccggataa tcacacctga ttcccttaaa aaggcacttg agtatcaaca gcgtaataat      660

aaggcaagtt atgtgtatgg gaatgatgca ttagcctatg gaagtcaggg tgatcttaat      720

ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga tgttaaagag      780

gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt ttcatatgga      840

cggaactcaa taaccctgac cacatcagca taa                                   873


<210>  81
<211>  290
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  81

Met Gly Ser Ser His His His His His His Leu Gln Val Asp Asn Lys 
1               5                   10                  15      


Phe Asn Lys Glu Met Ala Ser Ala Gly Gly Glu Ile Val Tyr Leu Pro 
            20                  25                  30          


Asn Leu Asn Pro Asp Gln Leu Cys Ala Phe Ile His Ser Leu His Asp 
        35                  40                  45              


Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys Lys Leu Asn 
    50                  55                  60                  


Asp Ala Gln Ala Pro Lys Val Asp Gly Asn Ser Leu Ala Lys Asn Val 
65                  70                  75                  80  


Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala 
                85                  90                  95      


Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr 
            100                 105                 110         


Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile 
        115                 120                 125             


Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp 
    130                 135                 140                 


Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr 
145                 150                 155                 160 


Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr 
                165                 170                 175     


Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln 
            180                 185                 190         


Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser 
        195                 200                 205             


Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr 
    210                 215                 220                 


Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn 
225                 230                 235                 240 


Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
                245                 250                 255     


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
            260                 265                 270         


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
        275                 280                 285             


Ser Ala 
    290 


<210>  82
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  82
agaggtaatt aaatgcatgg cgaaggtacc tttac                                  35


<210>  83
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  83
tgcaagagaa tttccagacg gcggcggg                                          28


<210>  84
<211>  936
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  84
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgcatggcga aggtaccttt      180

acgagtgatc tgagcaaaca gatggaagaa gaagcggtgc gtctgttcat tgaatggctg      240

aaaaacggcg gtccgagctc tggcgccccg ccgccgtctg gaaattctct tgcaaaaaat      300

gtattattcg gtggaaaagg taatgacaag ctgtacggca gtgagggggc agatctgctt      360

gatggtggag agggggatga tctcctgaaa ggcggatatg gtaatgatat ttatcgttat      420

ctgtcaggat atggtcatca tattattgat gatgatgggg ggaaagagga taaactcagt      480

ttggctgata ttgatttccg ggatgtggcc ttcaagcgag aaggtaatga cctcatcatg      540

tataaagctg aaggtaatgt tctttccatt ggtcataaaa atggtattac attcaggaac      600

tggtttgaaa aagagtcagg tgatatctct aatcaccaga tagagcagat ttttgataaa      660

agtggccgga taatcacacc tgattccctt aaaaaggcac ttgagtatca acagcgtaat      720

aataaggcaa gttatgtgta tgggaatgat gcattagcct atggaagtca gggtgatctt      780

aatccattaa ttaatgaaat cagcaaaatc atttcagctg caggtagctt cgatgttaaa      840

gaggaaagaa ctgcagcttc tttattgcag ttgtccggta atgccagtga tttttcatat      900

ggacggaact caataaccct gaccacatca gcataa                                936


<210>  85
<211>  777
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  85
atgcatggcg aaggtacctt tacgagtgat ctgagcaaac agatggaaga agaagcggtg       60

cgtctgttca ttgaatggct gaaaaacggc ggtccgagct ctggcgcccc gccgccgtct      120

ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag gtaatgacaa gctgtacggc      180

agtgaggggg cagatctgct tgatggtgga gagggggatg atctcctgaa aggcggatat      240

ggtaatgata tttatcgtta tctgtcagga tatggtcatc atattattga tgatgatggg      300

gggaaagagg ataaactcag tttggctgat attgatttcc gggatgtggc cttcaagcga      360

gaaggtaatg acctcatcat gtataaagct gaaggtaatg ttctttccat tggtcataaa      420

aatggtatta cattcaggaa ctggtttgaa aaagagtcag gtgatatctc taatcaccag      480

atagagcaga tttttgataa aagtggccgg ataatcacac ctgattccct taaaaaggca      540

cttgagtatc aacagcgtaa taataaggca agttatgtgt atgggaatga tgcattagcc      600

tatggaagtc agggtgatct taatccatta attaatgaaa tcagcaaaat catttcagct      660

gcaggtagct tcgatgttaa agaggaaaga actgcagctt ctttattgca gttgtccggt      720

aatgccagtg atttttcata tggacggaac tcaataaccc tgaccacatc agcataa         777


<210>  86
<211>  258
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  86

Met His Gly Glu Gly Thr Phe Thr Ser Asp Leu Ser Lys Gln Met Glu 
1               5                   10                  15      


Glu Glu Ala Val Arg Leu Phe Ile Glu Trp Leu Lys Asn Gly Gly Pro 
            20                  25                  30          


Ser Ser Gly Ala Pro Pro Pro Ser Gly Asn Ser Leu Ala Lys Asn Val 
        35                  40                  45              


Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala 
    50                  55                  60                  


Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr 
65                  70                  75                  80  


Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile 
                85                  90                  95      


Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp 
            100                 105                 110         


Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr 
        115                 120                 125             


Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr 
    130                 135                 140                 


Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln 
145                 150                 155                 160 


Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser 
                165                 170                 175     


Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr 
            180                 185                 190         


Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn 
        195                 200                 205             


Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
    210                 215                 220                 


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
225                 230                 235                 240 


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
                245                 250                 255     


Ser Ala 
        


<210>  87
<211>  35
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  87
agaggtaatt aaatgtatac cagcctgatt cattc                                  35


<210>  88
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  88
tgcaagagaa tttccaaacc agttccacag gctcgc                                 36


<210>  89
<211>  927
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  89
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtataccag cctgattcat      180

tctctgatcg aagaaagtca gaaccagcaa gagaaaaacg aacaagaact gctggaactg      240

gataaatggg cgagcctgtg gaactggttt ggaaattctc ttgcaaaaaa tgtattattc      300

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      360

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      420

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      480

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      540

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa      600

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg      660

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca      720

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta      780

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga      840

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac      900

tcaataaccc tgaccacatc agcataa                                          927


<210>  90
<211>  768
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  90
atgtatacca gcctgattca ttctctgatc gaagaaagtc agaaccagca agagaaaaac       60

gaacaagaac tgctggaact ggataaatgg gcgagcctgt ggaactggtt tggaaattct      120

cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg      180

gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata tggtaatgat      240

atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg ggggaaagag      300

gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg agaaggtaat      360

gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa aaatggtatt      420

acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca gatagagcag      480

atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc acttgagtat      540

caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc ctatggaagt      600

cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc      660

ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg taatgccagt      720

gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataa                   768


<210>  91
<211>  255
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  91

Met Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 
1               5                   10                  15      


Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 
            20                  25                  30          


Leu Trp Asn Trp Phe Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly 
        35                  40                  45              


Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu 
    50                  55                  60                  


Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp 
65                  70                  75                  80  


Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp 
                85                  90                  95      


Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp 
            100                 105                 110         


Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu 
        115                 120                 125             


Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn 
    130                 135                 140                 


Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln 
145                 150                 155                 160 


Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys 
                165                 170                 175     


Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly 
            180                 185                 190         


Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile 
        195                 200                 205             


Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys 
    210                 215                 220                 


Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser 
225                 230                 235                 240 


Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
                245                 250                 255 


<210>  92
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  92
agaggtaatt aaatgtgcgg caacctgag                                         29


<210>  93
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  93
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgcggcaa cctgagcacc      180

tgtatgctgg gtacctatac gcaggatttt aataaattcc atacctttcc gcagacggcg      240

attggcgtgg gtgccccggg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt      300

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat      360

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat      420

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg      480

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt      540

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt      600

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct      660

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat      720

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc      780

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct      840

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg      900

accacatcag cataa                                                       915


<210>  94
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  94
atgtgcggca acctgagcac ctgtatgctg ggtacctata cgcaggattt taataaattc       60

catacctttc cgcagacggc gattggcgtg ggtgccccgg gaaattctct tgcaaaaaat      120

gtattattcg gtggaaaagg taatgacaag ctgtacggca gtgagggggc agatctgctt      180

gatggtggag agggggatga tctcctgaaa ggcggatatg gtaatgatat ttatcgttat      240

ctgtcaggat atggtcatca tattattgat gatgatgggg ggaaagagga taaactcagt      300

ttggctgata ttgatttccg ggatgtggcc ttcaagcgag aaggtaatga cctcatcatg      360

tataaagctg aaggtaatgt tctttccatt ggtcataaaa atggtattac attcaggaac      420

tggtttgaaa aagagtcagg tgatatctct aatcaccaga tagagcagat ttttgataaa      480

agtggccgga taatcacacc tgattccctt aaaaaggcac ttgagtatca acagcgtaat      540

aataaggcaa gttatgtgta tgggaatgat gcattagcct atggaagtca gggtgatctt      600

aatccattaa ttaatgaaat cagcaaaatc atttcagctg caggtagctt cgatgttaaa      660

gaggaaagaa ctgcagcttc tttattgcag ttgtccggta atgccagtga tttttcatat      720

ggacggaact caataaccct gaccacatca gcataa                                756


<210>  95
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  95

Met Cys Gly Asn Leu Ser Thr Cys Met Leu Gly Thr Tyr Thr Gln Asp 
1               5                   10                  15      


Phe Asn Lys Phe His Thr Phe Pro Gln Thr Ala Ile Gly Val Gly Ala 
            20                  25                  30          


Pro Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
        35                  40                  45              


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
    50                  55                  60                  


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
65                  70                  75                  80  


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
                85                  90                  95      


Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys 
            100                 105                 110         


Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu 
        115                 120                 125             


Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys 
    130                 135                 140                 


Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys 
145                 150                 155                 160 


Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr 
                165                 170                 175     


Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu 
            180                 185                 190         


Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser 
        195                 200                 205             


Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr 
    210                 215                 220                 


Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr 
225                 230                 235                 240 


Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
                245                 250     


<210>  96
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  96
agaggtaatt aaatgtgcag caacctgtct acc                                    33


<210>  97
<211>  30
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  97
tgcaagagaa tttcccggcg taccgctgcc                                        30


<210>  98
<211>  915
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  98
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgcagcaa cctgtctacc      180

tgtgtgctgg gcaaactgag tcaggaactg cataaactgc agacctatcc gcgtaccaat      240

acgggcagcg gtacgccggg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt      300

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat      360

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat      420

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg      480

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt      540

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt      600

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct      660

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat      720

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc      780

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct      840

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg      900

accacatcag cataa                                                       915


<210>  99
<211>  756
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  99
atgtgcagca acctgtctac ctgtgtgctg ggcaaactga gtcaggaact gcataaactg       60

cagacctatc cgcgtaccaa tacgggcagc ggtacgccgg gaaattctct tgcaaaaaat      120

gtattattcg gtggaaaagg taatgacaag ctgtacggca gtgagggggc agatctgctt      180

gatggtggag agggggatga tctcctgaaa ggcggatatg gtaatgatat ttatcgttat      240

ctgtcaggat atggtcatca tattattgat gatgatgggg ggaaagagga taaactcagt      300

ttggctgata ttgatttccg ggatgtggcc ttcaagcgag aaggtaatga cctcatcatg      360

tataaagctg aaggtaatgt tctttccatt ggtcataaaa atggtattac attcaggaac      420

tggtttgaaa aagagtcagg tgatatctct aatcaccaga tagagcagat ttttgataaa      480

agtggccgga taatcacacc tgattccctt aaaaaggcac ttgagtatca acagcgtaat      540

aataaggcaa gttatgtgta tgggaatgat gcattagcct atggaagtca gggtgatctt      600

aatccattaa ttaatgaaat cagcaaaatc atttcagctg caggtagctt cgatgttaaa      660

gaggaaagaa ctgcagcttc tttattgcag ttgtccggta atgccagtga tttttcatat      720

ggacggaact caataaccct gaccacatca gcataa                                756


<210>  100
<211>  251
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  100

Met Cys Ser Asn Leu Ser Thr Cys Val Leu Gly Lys Leu Ser Gln Glu 
1               5                   10                  15      


Leu His Lys Leu Gln Thr Tyr Pro Arg Thr Asn Thr Gly Ser Gly Thr 
            20                  25                  30          


Pro Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
        35                  40                  45              


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
    50                  55                  60                  


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
65                  70                  75                  80  


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
                85                  90                  95      


Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys 
            100                 105                 110         


Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu 
        115                 120                 125             


Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys 
    130                 135                 140                 


Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys 
145                 150                 155                 160 


Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr 
                165                 170                 175     


Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu 
            180                 185                 190         


Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser 
        195                 200                 205             


Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr 
    210                 215                 220                 


Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr 
225                 230                 235                 240 


Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
                245                 250     


<210>  101
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  101
agaggtaatt aaatgagcga agaaccgccg att                                    33


<210>  102
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  102
tgcaagagaa tttccgataa tttccatcag tttacggttg ctg                         43


<210>  103
<211>  942
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  103
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgagcgaaga accgccgatt      180

tctctggatc tgacctttca tctgctgcgt gaagtgctgg aaatggcacg tgcagaacag      240

ctggcacagc aggcgcacag caaccgtaaa ctgatggaaa ttatcggaaa ttctcttgca      300

aaaaatgtat tattcggtgg aaaaggtaat gacaagctgt acggcagtga gggggcagat      360

ctgcttgatg gtggagaggg ggatgatctc ctgaaaggcg gatatggtaa tgatatttat      420

cgttatctgt caggatatgg tcatcatatt attgatgatg atggggggaa agaggataaa      480

ctcagtttgg ctgatattga tttccgggat gtggccttca agcgagaagg taatgacctc      540

atcatgtata aagctgaagg taatgttctt tccattggtc ataaaaatgg tattacattc      600

aggaactggt ttgaaaaaga gtcaggtgat atctctaatc accagataga gcagattttt      660

gataaaagtg gccggataat cacacctgat tcccttaaaa aggcacttga gtatcaacag      720

cgtaataata aggcaagtta tgtgtatggg aatgatgcat tagcctatgg aagtcagggt      780

gatcttaatc cattaattaa tgaaatcagc aaaatcattt cagctgcagg tagcttcgat      840

gttaaagagg aaagaactgc agcttcttta ttgcagttgt ccggtaatgc cagtgatttt      900

tcatatggac ggaactcaat aaccctgacc acatcagcat aa                         942


<210>  104
<211>  783
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  104
atgagcgaag aaccgccgat ttctctggat ctgacctttc atctgctgcg tgaagtgctg       60

gaaatggcac gtgcagaaca gctggcacag caggcgcaca gcaaccgtaa actgatggaa      120

attatcggaa attctcttgc aaaaaatgta ttattcggtg gaaaaggtaa tgacaagctg      180

tacggcagtg agggggcaga tctgcttgat ggtggagagg gggatgatct cctgaaaggc      240

ggatatggta atgatattta tcgttatctg tcaggatatg gtcatcatat tattgatgat      300

gatgggggga aagaggataa actcagtttg gctgatattg atttccggga tgtggccttc      360

aagcgagaag gtaatgacct catcatgtat aaagctgaag gtaatgttct ttccattggt      420

cataaaaatg gtattacatt caggaactgg tttgaaaaag agtcaggtga tatctctaat      480

caccagatag agcagatttt tgataaaagt ggccggataa tcacacctga ttcccttaaa      540

aaggcacttg agtatcaaca gcgtaataat aaggcaagtt atgtgtatgg gaatgatgca      600

ttagcctatg gaagtcaggg tgatcttaat ccattaatta atgaaatcag caaaatcatt      660

tcagctgcag gtagcttcga tgttaaagag gaaagaactg cagcttcttt attgcagttg      720

tccggtaatg ccagtgattt ttcatatgga cggaactcaa taaccctgac cacatcagca      780

taa                                                                    783


<210>  105
<211>  260
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  105

Met Ser Glu Glu Pro Pro Ile Ser Leu Asp Leu Thr Phe His Leu Leu 
1               5                   10                  15      


Arg Glu Val Leu Glu Met Ala Arg Ala Glu Gln Leu Ala Gln Gln Ala 
            20                  25                  30          


His Ser Asn Arg Lys Leu Met Glu Ile Ile Gly Asn Ser Leu Ala Lys 
        35                  40                  45              


Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu 
    50                  55                  60                  


Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly 
65                  70                  75                  80  


Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His 
                85                  90                  95      


Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp 
            100                 105                 110         


Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile 
        115                 120                 125             


Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly 
    130                 135                 140                 


Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn 
145                 150                 155                 160 


His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro 
                165                 170                 175     


Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala 
            180                 185                 190         


Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp 
        195                 200                 205             


Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
    210                 215                 220                 


Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu 
225                 230                 235                 240 


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
                245                 250                 255     


Thr Thr Ser Ala 
            260 


<210>  106
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  106
agaggtaatt aaatgagcga agaaccgccg att                                    33


<210>  107
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  107
cggcggttct tcgctgataa tttccatcag tttacggttg ctgt                        44


<210>  108
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  108
agcgaagaac cgccg                                                        15


<210>  109
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  109
catttaatta cctcttaacc agttaatg                                          28


<210>  110
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  110
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgagcgaaga accgccgatt      180

tctctggatc tgacctttca tctgctgcgt gaagtgctgg aaatggcacg tgcagaacag      240

ctggcacagc aggcgcacag caaccgtaaa ctgatggaaa ttatcagcga agaaccgccg      300

atttctctgg atctgacctt tcatctgctg cgtgaagtgc tggaaatggc acgtgcagaa      360

cagctggcac agcaggcgca cagcaaccgt aaactgatgg aaattatcgg aaattctctt      420

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      480

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      540

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      600

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      660

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca      720

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt      780

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa      840

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag      900

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc      960

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1020

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1065


<210>  111
<211>  906
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  111
atgagcgaag aaccgccgat ttctctggat ctgacctttc atctgctgcg tgaagtgctg       60

gaaatggcac gtgcagaaca gctggcacag caggcgcaca gcaaccgtaa actgatggaa      120

attatcagcg aagaaccgcc gatttctctg gatctgacct ttcatctgct gcgtgaagtg      180

ctggaaatgg cacgtgcaga acagctggca cagcaggcgc acagcaaccg taaactgatg      240

gaaattatcg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag      300

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa      360

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat      420

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc      480

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt      540

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct      600

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt      660

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat      720

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc      780

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag      840

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca      900

gcataa                                                                 906


<210>  112
<211>  301
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  112

Met Ser Glu Glu Pro Pro Ile Ser Leu Asp Leu Thr Phe His Leu Leu 
1               5                   10                  15      


Arg Glu Val Leu Glu Met Ala Arg Ala Glu Gln Leu Ala Gln Gln Ala 
            20                  25                  30          


His Ser Asn Arg Lys Leu Met Glu Ile Ile Ser Glu Glu Pro Pro Ile 
        35                  40                  45              


Ser Leu Asp Leu Thr Phe His Leu Leu Arg Glu Val Leu Glu Met Ala 
    50                  55                  60                  


Arg Ala Glu Gln Leu Ala Gln Gln Ala His Ser Asn Arg Lys Leu Met 
65                  70                  75                  80  


Glu Ile Ile Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys 
                85                  90                  95      


Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly 
            100                 105                 110         


Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr 
        115                 120                 125             


Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly 
    130                 135                 140                 


Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala 
145                 150                 155                 160 


Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn 
                165                 170                 175     


Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe 
            180                 185                 190         


Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe 
        195                 200                 205             


Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu 
    210                 215                 220                 


Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp 
225                 230                 235                 240 


Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu 
                245                 250                 255     


Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu 
            260                 265                 270         


Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe 
        275                 280                 285             


Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
    290                 295                 300     


<210>  113
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  113
agaggtaatt aaatgcagga cccatatgta aaagaag                                37


<210>  114
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  114
tgcaagagaa tttccacggc catcaatacc tcgaaacagc atctg                       45


<210>  115
<211>  1245
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  115
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgcaggaccc atatgtaaaa      180

gaagcagaaa accttaagaa atattttaat gcaggtcatt cagatgtagc ggataatgga      240

actcttttct taggcatttt gaagaattgg aaagaggaga gtgacagaaa aataatgcag      300

agccaaattg tctcctttta cttcaaactt tttaaaaact ttaaagatga ccagagcatc      360

caaaagagtg tggagaccat caaggaagac atgaatgtca agtttttcaa tagcaacaaa      420

aagaaacgag atgacttcga aaagctgact aattattcgg taactgactt gaatgtccaa      480

cgcaaagcaa tacatgaact catccaagtg atggctgaac tgtcgccagc agctaaaaca      540

gggaagcgaa aaaggagtca gatgctgttt cgaggtattg atggccgtgg aaattctctt      600

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      660

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      720

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      780

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      840

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca      900

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt      960

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa     1020

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag     1080

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc     1140

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1200

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1245


<210>  116
<211>  1086
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  116
atgcaggacc catatgtaaa agaagcagaa aaccttaaga aatattttaa tgcaggtcat       60

tcagatgtag cggataatgg aactcttttc ttaggcattt tgaagaattg gaaagaggag      120

agtgacagaa aaataatgca gagccaaatt gtctcctttt acttcaaact ttttaaaaac      180

tttaaagatg accagagcat ccaaaagagt gtggagacca tcaaggaaga catgaatgtc      240

aagtttttca atagcaacaa aaagaaacga gatgacttcg aaaagctgac taattattcg      300

gtaactgact tgaatgtcca acgcaaagca atacatgaac tcatccaagt gatggctgaa      360

ctgtcgccag cagctaaaac agggaagcga aaaaggagtc agatgctgtt tcgaggtatt      420

gatggccgtg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag      480

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa      540

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat      600

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc      660

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt      720

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct      780

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt      840

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat      900

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc      960

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag     1020

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca     1080

gcataa                                                                1086


<210>  117
<211>  361
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  117

Met Gln Asp Pro Tyr Val Lys Glu Ala Glu Asn Leu Lys Lys Tyr Phe 
1               5                   10                  15      


Asn Ala Gly His Ser Asp Val Ala Asp Asn Gly Thr Leu Phe Leu Gly 
            20                  25                  30          


Ile Leu Lys Asn Trp Lys Glu Glu Ser Asp Arg Lys Ile Met Gln Ser 
        35                  40                  45              


Gln Ile Val Ser Phe Tyr Phe Lys Leu Phe Lys Asn Phe Lys Asp Asp 
    50                  55                  60                  


Gln Ser Ile Gln Lys Ser Val Glu Thr Ile Lys Glu Asp Met Asn Val 
65                  70                  75                  80  


Lys Phe Phe Asn Ser Asn Lys Lys Lys Arg Asp Asp Phe Glu Lys Leu 
                85                  90                  95      


Thr Asn Tyr Ser Val Thr Asp Leu Asn Val Gln Arg Lys Ala Ile His 
            100                 105                 110         


Glu Leu Ile Gln Val Met Ala Glu Leu Ser Pro Ala Ala Lys Thr Gly 
        115                 120                 125             


Lys Arg Lys Arg Ser Gln Met Leu Phe Arg Gly Ile Asp Gly Arg Gly 
    130                 135                 140                 


Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys 
145                 150                 155                 160 


Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp 
                165                 170                 175     


Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser 
            180                 185                 190         


Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys 
        195                 200                 205             


Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu 
    210                 215                 220                 


Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile 
225                 230                 235                 240 


Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser 
                245                 250                 255     


Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly 
            260                 265                 270         


Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln 
        275                 280                 285             


Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr 
    290                 295                 300                 


Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile 
305                 310                 315                 320 


Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala 
                325                 330                 335     


Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg 
            340                 345                 350         


Asn Ser Ile Thr Leu Thr Thr Ser Ala 
        355                 360     


<210>  118
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  118
agaggtaatt aaatgcacgg cacagtcatt gaaa                                   34


<210>  119
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  119
tgcaagagaa tttccacggc catcaatgca gcgactcctt ttcc                        44


<210>  120
<211>  1230
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  120
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgcacggcac agtcattgaa      180

agcctagaaa gtctgaataa ctattttaac tcaagtggca tagatgtgga agaaaagagt      240

ctcttcttgg atatctggag gaactggcaa aaggatggtg acatgaaaat cctgcagagc      300

cagattatct ctttctacct cagactcttt gaagtcttga aagacaatca ggccatcagc      360

aacaacataa gcgtcattga atcacacctg attactacct tcttcagcaa cagcaaggcg      420

aaaaaggatg cattcatgag tattgccaag tttgaggtca acaacccaca ggtccagcgc      480

caagcattca atgagctcat ccgagtggtc caccagctgt tgccggaatc cagcctcagg      540

aagcggaaaa ggagtcgctg cattgatggc cgtggaaatt ctcttgcaaa aaatgtatta      600

ttcggtggaa aaggtaatga caagctgtac ggcagtgagg gggcagatct gcttgatggt      660

ggagaggggg atgatctcct gaaaggcgga tatggtaatg atatttatcg ttatctgtca      720

ggatatggtc atcatattat tgatgatgat ggggggaaag aggataaact cagtttggct      780

gatattgatt tccgggatgt ggccttcaag cgagaaggta atgacctcat catgtataaa      840

gctgaaggta atgttctttc cattggtcat aaaaatggta ttacattcag gaactggttt      900

gaaaaagagt caggtgatat ctctaatcac cagatagagc agatttttga taaaagtggc      960

cggataatca cacctgattc ccttaaaaag gcacttgagt atcaacagcg taataataag     1020

gcaagttatg tgtatgggaa tgatgcatta gcctatggaa gtcagggtga tcttaatcca     1080

ttaattaatg aaatcagcaa aatcatttca gctgcaggta gcttcgatgt taaagaggaa     1140

agaactgcag cttctttatt gcagttgtcc ggtaatgcca gtgatttttc atatggacgg     1200

aactcaataa ccctgaccac atcagcataa                                      1230


<210>  121
<211>  1071
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  121
atgcacggca cagtcattga aagcctagaa agtctgaata actattttaa ctcaagtggc       60

atagatgtgg aagaaaagag tctcttcttg gatatctgga ggaactggca aaaggatggt      120

gacatgaaaa tcctgcagag ccagattatc tctttctacc tcagactctt tgaagtcttg      180

aaagacaatc aggccatcag caacaacata agcgtcattg aatcacacct gattactacc      240

ttcttcagca acagcaaggc gaaaaaggat gcattcatga gtattgccaa gtttgaggtc      300

aacaacccac aggtccagcg ccaagcattc aatgagctca tccgagtggt ccaccagctg      360

ttgccggaat ccagcctcag gaagcggaaa aggagtcgct gcattgatgg ccgtggaaat      420

tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta cggcagtgag      480

ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg atatggtaat      540

gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga tggggggaaa      600

gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa gcgagaaggt      660

aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca taaaaatggt      720

attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca ccagatagag      780

cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa ggcacttgag      840

tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt agcctatgga      900

agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc agctgcaggt      960

agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc cggtaatgcc     1020

agtgattttt catatggacg gaactcaata accctgacca catcagcata a              1071


<210>  122
<211>  356
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  122

Met His Gly Thr Val Ile Glu Ser Leu Glu Ser Leu Asn Asn Tyr Phe 
1               5                   10                  15      


Asn Ser Ser Gly Ile Asp Val Glu Glu Lys Ser Leu Phe Leu Asp Ile 
            20                  25                  30          


Trp Arg Asn Trp Gln Lys Asp Gly Asp Met Lys Ile Leu Gln Ser Gln 
        35                  40                  45              


Ile Ile Ser Phe Tyr Leu Arg Leu Phe Glu Val Leu Lys Asp Asn Gln 
    50                  55                  60                  


Ala Ile Ser Asn Asn Ile Ser Val Ile Glu Ser His Leu Ile Thr Thr 
65                  70                  75                  80  


Phe Phe Ser Asn Ser Lys Ala Lys Lys Asp Ala Phe Met Ser Ile Ala 
                85                  90                  95      


Lys Phe Glu Val Asn Asn Pro Gln Val Gln Arg Gln Ala Phe Asn Glu 
            100                 105                 110         


Leu Ile Arg Val Val His Gln Leu Leu Pro Glu Ser Ser Leu Arg Lys 
        115                 120                 125             


Arg Lys Arg Ser Arg Cys Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys 
    130                 135                 140                 


Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu 
145                 150                 155                 160 


Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly 
                165                 170                 175     


Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His 
            180                 185                 190         


Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp 
        195                 200                 205             


Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile 
    210                 215                 220                 


Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly 
225                 230                 235                 240 


Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn 
                245                 250                 255     


His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro 
            260                 265                 270         


Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala 
        275                 280                 285             


Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp 
    290                 295                 300                 


Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
305                 310                 315                 320 


Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu 
                325                 330                 335     


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
            340                 345                 350         


Thr Thr Ser Ala 
        355     


<210>  123
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  123
agaggtaatt aaatgtgtga tctgccgcag actc                                   34


<210>  124
<211>  58
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  124
tgcaagagaa tttccacggc catcaatttc cttacttctt aaactttctt gcaagttt         58


<210>  125
<211>  1326
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  125
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgtgatct gccgcagact      180

cactctctgg gttctcgtcg tactctgatg ctgctggctc agatgcgtcg tatctctctt      240

ttctcctgct tgaaggaccg tcatgacttt ggatttcccc aggaggagtt tggcaaccag      300

ttccaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcaatctc      360

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      420

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      480

gagactcccc tgatgaagga ggactccatt ctggctgtga ggaaatactt ccaaagaatc      540

actctctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      600

atcatgagat ctttttcttt gtcaacaaac ttgcaggaaa gtttaagaag taaggaaatt      660

gatggccgtg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag      720

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa      780

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat      840

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc      900

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt      960

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct     1020

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt     1080

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat     1140

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc     1200

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag     1260

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca     1320

gcataa                                                                1326


<210>  126
<211>  1167
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  126
atgtgtgatc tgccgcagac tcactctctg ggttctcgtc gtactctgat gctgctggct       60

cagatgcgtc gtatctctct tttctcctgc ttgaaggacc gtcatgactt tggatttccc      120

caggaggagt ttggcaacca gttccaaaag gctgaaacca tccctgtcct ccatgagatg      180

atccagcaga tcttcaatct cttcagcaca aaggactcat ctgctgcttg ggatgagacc      240

ctcctagaca aattctacac tgaactctac cagcagctga atgacctgga agcctgtgtg      300

atacaggggg tgggggtgac agagactccc ctgatgaagg aggactccat tctggctgtg      360

aggaaatact tccaaagaat cactctctat ctgaaagaga agaaatacag cccttgtgcc      420

tgggaggttg tcagagcaga aatcatgaga tctttttctt tgtcaacaaa cttgcaggaa      480

agtttaagaa gtaaggaaat tgatggccgt ggaaattctc ttgcaaaaaa tgtattattc      540

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      600

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      660

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      720

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      780

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa      840

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg      900

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca      960

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta     1020

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga     1080

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac     1140

tcaataaccc tgaccacatc agcataa                                         1167


<210>  127
<211>  388
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  127

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu 
1               5                   10                  15      


Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met 
            100                 105                 110         


Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Ser Leu Arg Ser Lys Glu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys 
                165                 170                 175     


Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu 
            180                 185                 190         


Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly 
        195                 200                 205             


Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His 
    210                 215                 220                 


Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp 
225                 230                 235                 240 


Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile 
                245                 250                 255     


Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly 
            260                 265                 270         


Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn 
        275                 280                 285             


His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro 
    290                 295                 300                 


Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala 
305                 310                 315                 320 


Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp 
                325                 330                 335     


Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly 
            340                 345                 350         


Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu 
        355                 360                 365             


Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu 
    370                 375                 380                 


Thr Thr Ser Ala 
385             


<210>  128
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  128
agaggtaatt aaatgagtac aaaagatttt aacttggatt t                           41


<210>  129
<211>  41
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  129
tgcaagagaa tttcctttgc ttacgtgaat actacaatga c                           41


<210>  130
<211>  987
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  130
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgagtacaaa agattttaac      180

ttggatttgg tatctgtttc gaagaaagat tcaggtgcat caccacgcat tacaagtatt      240

tcgctatgta cacccggttg taaaacagga gctctgatgg gttgtaacat gaaaacagca      300

acttgtcatt gtagtattca cgtaagcaaa ggaaattctc ttgcaaaaaa tgtattattc      360

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      420

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      480

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      540

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      600

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa      660

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg      720

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca      780

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta      840

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga      900

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac      960

tcaataaccc tgaccacatc agcataa                                          987


<210>  131
<211>  828
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  131
atgagtacaa aagattttaa cttggatttg gtatctgttt cgaagaaaga ttcaggtgca       60

tcaccacgca ttacaagtat ttcgctatgt acacccggtt gtaaaacagg agctctgatg      120

ggttgtaaca tgaaaacagc aacttgtcat tgtagtattc acgtaagcaa aggaaattct      180

cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg      240

gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata tggtaatgat      300

atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg ggggaaagag      360

gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg agaaggtaat      420

gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa aaatggtatt      480

acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca gatagagcag      540

atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc acttgagtat      600

caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc ctatggaagt      660

cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc      720

ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg taatgccagt      780

gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataa                   828


<210>  132
<211>  275
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  132

Met Ser Thr Lys Asp Phe Asn Leu Asp Leu Val Ser Val Ser Lys Lys 
1               5                   10                  15      


Asp Ser Gly Ala Ser Pro Arg Ile Thr Ser Ile Ser Leu Cys Thr Pro 
            20                  25                  30          


Gly Cys Lys Thr Gly Ala Leu Met Gly Cys Asn Met Lys Thr Ala Thr 
        35                  40                  45              


Cys His Cys Ser Ile His Val Ser Lys Gly Asn Ser Leu Ala Lys Asn 
    50                  55                  60                  


Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly 
65                  70                  75                  80  


Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly 
                85                  90                  95      


Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile 
            100                 105                 110         


Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile 
        115                 120                 125             


Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met 
    130                 135                 140                 


Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile 
145                 150                 155                 160 


Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His 
                165                 170                 175     


Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp 
            180                 185                 190         


Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser 
        195                 200                 205             


Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu 
    210                 215                 220                 


Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser 
225                 230                 235                 240 


Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser 
                245                 250                 255     


Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr 
            260                 265                 270         


Thr Ser Ala 
        275 


<210>  133
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  133
agaggtaatt aaatgaaaaa tctaaaatct cctcaaaaag tagag                       45


<210>  134
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  134
tgcaagagaa tttccatttt ctggtggagg tagt                                   34


<210>  135
<211>  1440
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  135
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgaaaaatct aaaatctcct      180

caaaaagtag aggtcgacat catagatgac aactttatcc tgaggtggaa caggagcgat      240

gagtctgtcg ggaatgtgac tttttcattc gattatcaaa aaactgggat ggataattgg      300

ataaaattgt ctgggtgtca gaatattact agtaccaaat gcaacttttc ttcactcaag      360

ctgaatgttt atgaagaaat taaattgcgt ataagagcag aaaaagaaaa cacttcttca      420

tggtatgagg ttgactcatt tacaccattt cgcaaagctc agattggtcc tccagaagta      480

catttagaag ctgaagataa ggcaatagtg atacacatct ctcctggaac aaaagatagt      540

gttatgtggg ctttggatgg tttaagcttt acatatagct tacttatctg gaaaaactct      600

tcaggtgtag aagaaaggat tgaaaatatt tattccagac ataaaattta taaactctca      660

ccagagacta cttattgtct aaaagttaaa gcagcactac ttacgtcatg gaaaattggt      720

gtctatagtc cagtacattg tataaagacc acagttgaaa atgaactacc tccaccagaa      780

aatggaaatt ctcttgcaaa aaatgtatta ttcggtggaa aaggtaatga caagctgtac      840

ggcagtgagg gggcagatct gcttgatggt ggagaggggg atgatctcct gaaaggcgga      900

tatggtaatg atatttatcg ttatctgtca ggatatggtc atcatattat tgatgatgat      960

ggggggaaag aggataaact cagtttggct gatattgatt tccgggatgt ggccttcaag     1020

cgagaaggta atgacctcat catgtataaa gctgaaggta atgttctttc cattggtcat     1080

aaaaatggta ttacattcag gaactggttt gaaaaagagt caggtgatat ctctaatcac     1140

cagatagagc agatttttga taaaagtggc cggataatca cacctgattc ccttaaaaag     1200

gcacttgagt atcaacagcg taataataag gcaagttatg tgtatgggaa tgatgcatta     1260

gcctatggaa gtcagggtga tcttaatcca ttaattaatg aaatcagcaa aatcatttca     1320

gctgcaggta gcttcgatgt taaagaggaa agaactgcag cttctttatt gcagttgtcc     1380

ggtaatgcca gtgatttttc atatggacgg aactcaataa ccctgaccac atcagcataa     1440


<210>  136
<211>  1281
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  136
atgaaaaatc taaaatctcc tcaaaaagta gaggtcgaca tcatagatga caactttatc       60

ctgaggtgga acaggagcga tgagtctgtc gggaatgtga ctttttcatt cgattatcaa      120

aaaactggga tggataattg gataaaattg tctgggtgtc agaatattac tagtaccaaa      180

tgcaactttt cttcactcaa gctgaatgtt tatgaagaaa ttaaattgcg tataagagca      240

gaaaaagaaa acacttcttc atggtatgag gttgactcat ttacaccatt tcgcaaagct      300

cagattggtc ctccagaagt acatttagaa gctgaagata aggcaatagt gatacacatc      360

tctcctggaa caaaagatag tgttatgtgg gctttggatg gtttaagctt tacatatagc      420

ttacttatct ggaaaaactc ttcaggtgta gaagaaagga ttgaaaatat ttattccaga      480

cataaaattt ataaactctc accagagact acttattgtc taaaagttaa agcagcacta      540

cttacgtcat ggaaaattgg tgtctatagt ccagtacatt gtataaagac cacagttgaa      600

aatgaactac ctccaccaga aaatggaaat tctcttgcaa aaaatgtatt attcggtgga      660

aaaggtaatg acaagctgta cggcagtgag ggggcagatc tgcttgatgg tggagagggg      720

gatgatctcc tgaaaggcgg atatggtaat gatatttatc gttatctgtc aggatatggt      780

catcatatta ttgatgatga tggggggaaa gaggataaac tcagtttggc tgatattgat      840

ttccgggatg tggccttcaa gcgagaaggt aatgacctca tcatgtataa agctgaaggt      900

aatgttcttt ccattggtca taaaaatggt attacattca ggaactggtt tgaaaaagag      960

tcaggtgata tctctaatca ccagatagag cagatttttg ataaaagtgg ccggataatc     1020

acacctgatt cccttaaaaa ggcacttgag tatcaacagc gtaataataa ggcaagttat     1080

gtgtatggga atgatgcatt agcctatgga agtcagggtg atcttaatcc attaattaat     1140

gaaatcagca aaatcatttc agctgcaggt agcttcgatg ttaaagagga aagaactgca     1200

gcttctttat tgcagttgtc cggtaatgcc agtgattttt catatggacg gaactcaata     1260

accctgacca catcagcata a                                               1281


<210>  137
<211>  426
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  137

Met Lys Asn Leu Lys Ser Pro Gln Lys Val Glu Val Asp Ile Ile Asp 
1               5                   10                  15      


Asp Asn Phe Ile Leu Arg Trp Asn Arg Ser Asp Glu Ser Val Gly Asn 
            20                  25                  30          


Val Thr Phe Ser Phe Asp Tyr Gln Lys Thr Gly Met Asp Asn Trp Ile 
        35                  40                  45              


Lys Leu Ser Gly Cys Gln Asn Ile Thr Ser Thr Lys Cys Asn Phe Ser 
    50                  55                  60                  


Ser Leu Lys Leu Asn Val Tyr Glu Glu Ile Lys Leu Arg Ile Arg Ala 
65                  70                  75                  80  


Glu Lys Glu Asn Thr Ser Ser Trp Tyr Glu Val Asp Ser Phe Thr Pro 
                85                  90                  95      


Phe Arg Lys Ala Gln Ile Gly Pro Pro Glu Val His Leu Glu Ala Glu 
            100                 105                 110         


Asp Lys Ala Ile Val Ile His Ile Ser Pro Gly Thr Lys Asp Ser Val 
        115                 120                 125             


Met Trp Ala Leu Asp Gly Leu Ser Phe Thr Tyr Ser Leu Leu Ile Trp 
    130                 135                 140                 


Lys Asn Ser Ser Gly Val Glu Glu Arg Ile Glu Asn Ile Tyr Ser Arg 
145                 150                 155                 160 


His Lys Ile Tyr Lys Leu Ser Pro Glu Thr Thr Tyr Cys Leu Lys Val 
                165                 170                 175     


Lys Ala Ala Leu Leu Thr Ser Trp Lys Ile Gly Val Tyr Ser Pro Val 
            180                 185                 190         


His Cys Ile Lys Thr Thr Val Glu Asn Glu Leu Pro Pro Pro Glu Asn 
        195                 200                 205             


Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp 
    210                 215                 220                 


Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly 
225                 230                 235                 240 


Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu 
                245                 250                 255     


Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp 
            260                 265                 270         


Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg 
        275                 280                 285             


Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser 
    290                 295                 300                 


Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu 
305                 310                 315                 320 


Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser 
                325                 330                 335     


Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln 
            340                 345                 350         


Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala 
        355                 360                 365             


Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys 
    370                 375                 380                 


Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala 
385                 390                 395                 400 


Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly 
                405                 410                 415     


Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
            420                 425     


<210>  138
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  138
agaggtaatt aaatggaaaa tgaactacct ccaccag                                37


<210>  139
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  139
tgcaagagaa tttcctttag aggtatttcc tggtttt                                37


<210>  140
<211>  1452
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  140
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggaaaatga actacctcca      180

ccagaaaata tagaagtcag tgtccaaaat cagaactatg ttcttaaatg ggattataca      240

tatgcaaaca tgacctttca agttcagtgg ctccacgcct ttttaaaaag gaatcctgga      300

aaccatttgt ataaatggaa acaaatacct gactgtgaaa atgtcaaaac tacccagtgt      360

gtctttcctc aaaacgtttt ccaaaaagga atttaccttc tccgcgtaca agcatctgat      420

ggaaataaca catctttttg gtctgaagag ataaagtttg atactgaaat acaagctttc      480

ctacttcctc cagtctttaa cattagatcc cttagtgatt cattccatat ctatatcggt      540

gctccaaaac agtctggaaa cacgcctgtg atccaggatt atccactgat ttatgaaatt      600

attttttggg aaaacacttc aaatgctgag agaaaaatta tcgagaaaaa aactgatgtt      660

acagttccta atttgaaacc actgactgta tattgtgtga aagccagagc acacaccatg      720

gatgaaaagc tgaataaaag cagtgttttt agtgacgctg tatgtgagaa aacaaaacca      780

ggaaatacct ctaaaggaaa ttctcttgca aaaaatgtat tattcggtgg aaaaggtaat      840

gacaagctgt acggcagtga gggggcagat ctgcttgatg gtggagaggg ggatgatctc      900

ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg tcatcatatt      960

attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat     1020

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt     1080

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat     1140

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat     1200

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg     1260

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc     1320

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta     1380

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc     1440

acatcagcat aa                                                         1452


<210>  141
<211>  1293
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  141
atggaaaatg aactacctcc accagaaaat atagaagtca gtgtccaaaa tcagaactat       60

gttcttaaat gggattatac atatgcaaac atgacctttc aagttcagtg gctccacgcc      120

tttttaaaaa ggaatcctgg aaaccatttg tataaatgga aacaaatacc tgactgtgaa      180

aatgtcaaaa ctacccagtg tgtctttcct caaaacgttt tccaaaaagg aatttacctt      240

ctccgcgtac aagcatctga tggaaataac acatcttttt ggtctgaaga gataaagttt      300

gatactgaaa tacaagcttt cctacttcct ccagtcttta acattagatc ccttagtgat      360

tcattccata tctatatcgg tgctccaaaa cagtctggaa acacgcctgt gatccaggat      420

tatccactga tttatgaaat tattttttgg gaaaacactt caaatgctga gagaaaaatt      480

atcgagaaaa aaactgatgt tacagttcct aatttgaaac cactgactgt atattgtgtg      540

aaagccagag cacacaccat ggatgaaaag ctgaataaaa gcagtgtttt tagtgacgct      600

gtatgtgaga aaacaaaacc aggaaatacc tctaaaggaa attctcttgc aaaaaatgta      660

ttattcggtg gaaaaggtaa tgacaagctg tacggcagtg agggggcaga tctgcttgat      720

ggtggagagg gggatgatct cctgaaaggc ggatatggta atgatattta tcgttatctg      780

tcaggatatg gtcatcatat tattgatgat gatgggggga aagaggataa actcagtttg      840

gctgatattg atttccggga tgtggccttc aagcgagaag gtaatgacct catcatgtat      900

aaagctgaag gtaatgttct ttccattggt cataaaaatg gtattacatt caggaactgg      960

tttgaaaaag agtcaggtga tatctctaat caccagatag agcagatttt tgataaaagt     1020

ggccggataa tcacacctga ttcccttaaa aaggcacttg agtatcaaca gcgtaataat     1080

aaggcaagtt atgtgtatgg gaatgatgca ttagcctatg gaagtcaggg tgatcttaat     1140

ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga tgttaaagag     1200

gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt ttcatatgga     1260

cggaactcaa taaccctgac cacatcagca taa                                  1293


<210>  142
<211>  430
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  142

Met Glu Asn Glu Leu Pro Pro Pro Glu Asn Ile Glu Val Ser Val Gln 
1               5                   10                  15      


Asn Gln Asn Tyr Val Leu Lys Trp Asp Tyr Thr Tyr Ala Asn Met Thr 
            20                  25                  30          


Phe Gln Val Gln Trp Leu His Ala Phe Leu Lys Arg Asn Pro Gly Asn 
        35                  40                  45              


His Leu Tyr Lys Trp Lys Gln Ile Pro Asp Cys Glu Asn Val Lys Thr 
    50                  55                  60                  


Thr Gln Cys Val Phe Pro Gln Asn Val Phe Gln Lys Gly Ile Tyr Leu 
65                  70                  75                  80  


Leu Arg Val Gln Ala Ser Asp Gly Asn Asn Thr Ser Phe Trp Ser Glu 
                85                  90                  95      


Glu Ile Lys Phe Asp Thr Glu Ile Gln Ala Phe Leu Leu Pro Pro Val 
            100                 105                 110         


Phe Asn Ile Arg Ser Leu Ser Asp Ser Phe His Ile Tyr Ile Gly Ala 
        115                 120                 125             


Pro Lys Gln Ser Gly Asn Thr Pro Val Ile Gln Asp Tyr Pro Leu Ile 
    130                 135                 140                 


Tyr Glu Ile Ile Phe Trp Glu Asn Thr Ser Asn Ala Glu Arg Lys Ile 
145                 150                 155                 160 


Ile Glu Lys Lys Thr Asp Val Thr Val Pro Asn Leu Lys Pro Leu Thr 
                165                 170                 175     


Val Tyr Cys Val Lys Ala Arg Ala His Thr Met Asp Glu Lys Leu Asn 
            180                 185                 190         


Lys Ser Ser Val Phe Ser Asp Ala Val Cys Glu Lys Thr Lys Pro Gly 
        195                 200                 205             


Asn Thr Ser Lys Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly 
    210                 215                 220                 


Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp 
225                 230                 235                 240 


Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile 
                245                 250                 255     


Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly 
            260                 265                 270         


Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val 
        275                 280                 285             


Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly 
    290                 295                 300                 


Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp 
305                 310                 315                 320 


Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile 
                325                 330                 335     


Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala 
            340                 345                 350         


Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn 
        355                 360                 365             


Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn 
    370                 375                 380                 


Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu 
385                 390                 395                 400 


Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp 
                405                 410                 415     


Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
            420                 425                 430 


<210>  143
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  143
agaggtaatt aaatggcatt tgatggcact tggaaagtag ac                          42


<210>  144
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  144
tgcaagagaa tttccacggc catcaatttc cttcttaaag atccgcttgg c                51


<210>  145
<211>  1224
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  145
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggcatttga tggcacttgg      180

aaagtagacc ggaatgagaa ctatgaaaag ttcatggaga aaatgggcat taacgtggtg      240

aagaggaagc ttggagctca tgacaacttg aaactgacga tcacacagga aggaaataaa      300

ttcacagtca aagaatcaag caacttccga aacattgatg ttgtgtttga actcggcgtc      360

gactttgcct atagtctagc agatggaaca gaactcactg ggacctggac catggaggga      420

aataaacttg ttggaaaatt caaacgtgta gacaatggaa aggagctgat tgctgtccga      480

gagatttctg gtaacgaact aatccaaacc tacacatatg aaggagtgga ggccaagcgg      540

atctttaaga aggaaattga tggccgtgga aattctcttg caaaaaatgt attattcggt      600

ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga tggtggagag      660

ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct gtcaggatat      720

ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt ggctgatatt      780

gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta taaagctgaa      840

ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg gtttgaaaaa      900

gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag tggccggata      960

atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa taaggcaagt     1020

tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa tccattaatt     1080

aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga ggaaagaact     1140

gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg acggaactca     1200

ataaccctga ccacatcagc ataa                                            1224


<210>  146
<211>  1065
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  146
atggcatttg atggcacttg gaaagtagac cggaatgaga actatgaaaa gttcatggag       60

aaaatgggca ttaacgtggt gaagaggaag cttggagctc atgacaactt gaaactgacg      120

atcacacagg aaggaaataa attcacagtc aaagaatcaa gcaacttccg aaacattgat      180

gttgtgtttg aactcggcgt cgactttgcc tatagtctag cagatggaac agaactcact      240

gggacctgga ccatggaggg aaataaactt gttggaaaat tcaaacgtgt agacaatgga      300

aaggagctga ttgctgtccg agagatttct ggtaacgaac taatccaaac ctacacatat      360

gaaggagtgg aggccaagcg gatctttaag aaggaaattg atggccgtgg aaattctctt      420

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      480

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      540

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      600

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      660

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca      720

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt      780

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa      840

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag      900

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc      960

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1020

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1065


<210>  147
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  147

Met Ala Phe Asp Gly Thr Trp Lys Val Asp Arg Asn Glu Asn Tyr Glu 
1               5                   10                  15      


Lys Phe Met Glu Lys Met Gly Ile Asn Val Val Lys Arg Lys Leu Gly 
            20                  25                  30          


Ala His Asp Asn Leu Lys Leu Thr Ile Thr Gln Glu Gly Asn Lys Phe 
        35                  40                  45              


Thr Val Lys Glu Ser Ser Asn Phe Arg Asn Ile Asp Val Val Phe Glu 
    50                  55                  60                  


Leu Gly Val Asp Phe Ala Tyr Ser Leu Ala Asp Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Gly Thr Trp Thr Met Glu Gly Asn Lys Leu Val Gly Lys Phe Lys Arg 
                85                  90                  95      


Val Asp Asn Gly Lys Glu Leu Ile Ala Val Arg Glu Ile Ser Gly Asn 
            100                 105                 110         


Glu Leu Ile Gln Thr Tyr Thr Tyr Glu Gly Val Glu Ala Lys Arg Ile 
        115                 120                 125             


Phe Lys Lys Glu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val 
    130                 135                 140                 


Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala 
145                 150                 155                 160 


Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr 
                165                 170                 175     


Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile 
            180                 185                 190         


Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp 
        195                 200                 205             


Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr 
    210                 215                 220                 


Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr 
225                 230                 235                 240 


Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln 
                245                 250                 255     


Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser 
            260                 265                 270         


Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr 
        275                 280                 285             


Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn 
    290                 295                 300                 


Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
305                 310                 315                 320 


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
                325                 330                 335     


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
            340                 345                 350         


Ser Ala 
        


<210>  148
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  148

Met Ala Phe Asp Gly Thr Trp Lys Val Asp Arg Asn Glu Asn Tyr Glu 
1               5                   10                  15      


Lys Phe Met Glu Lys Met Gly Ile Asn Val Val Lys Arg Lys Leu Gly 
            20                  25                  30          


Ala His Asp Asn Leu Lys Leu Thr Ile Thr Gln Glu Gly Asn Lys Phe 
        35                  40                  45              


Thr Val Lys Glu Ser Ser Asn Phe Arg Asn Ile Asp Val Val Phe Glu 
    50                  55                  60                  


Leu Gly Val Asp Phe Ala Tyr Ser Leu Ala Asp Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Val Thr Trp Thr Met Glu Gly Asn Lys Leu Val Gly Lys Phe Lys Arg 
                85                  90                  95      


Val Asp Asn Gly Lys Glu Leu Ile Ala Val Arg Glu Ile Ser Gly Asn 
            100                 105                 110         


Glu Leu Ile Gln Thr Tyr Thr Tyr Glu Gly Val Glu Ala Lys Arg Ile 
        115                 120                 125             


Phe Lys Lys Glu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val 
    130                 135                 140                 


Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala 
145                 150                 155                 160 


Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr 
                165                 170                 175     


Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile 
            180                 185                 190         


Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp 
        195                 200                 205             


Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr 
    210                 215                 220                 


Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr 
225                 230                 235                 240 


Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln 
                245                 250                 255     


Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser 
            260                 265                 270         


Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr 
        275                 280                 285             


Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn 
    290                 295                 300                 


Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
305                 310                 315                 320 


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
                325                 330                 335     


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
            340                 345                 350         


Ser Ala 
        


<210>  149
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  149

Met Ala Phe Asp Gly Thr Trp Lys Val Asp Arg Asn Glu Asn Tyr Glu 
1               5                   10                  15      


Lys Phe Met Glu Lys Met Gly Ile Asn Val Val Lys Arg Lys Leu Gly 
            20                  25                  30          


Ala His Asp Asn Leu Lys Leu Thr Ile Thr Gln Glu Gly Asn Lys Phe 
        35                  40                  45              


Thr Val Lys Glu Ser Ser Asn Phe Arg Asn Ile Asp Val Val Phe Glu 
    50                  55                  60                  


Leu Gly Val Asp Phe Ala Tyr Ser Leu Ala Asp Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Gly Thr Trp Thr Met Glu Gly Asn Lys Leu Val Gly Lys Phe Lys Arg 
                85                  90                  95      


Val Asp Asn Gly Lys Glu Leu Ile Ala Val Arg Glu Ile Ser Gly Asn 
            100                 105                 110         


Glu Leu Ile Gln Thr Tyr Thr Tyr Glu Val Val Glu Ala Lys Arg Ile 
        115                 120                 125             


Phe Lys Lys Glu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val 
    130                 135                 140                 


Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala 
145                 150                 155                 160 


Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr 
                165                 170                 175     


Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile 
            180                 185                 190         


Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp 
        195                 200                 205             


Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr 
    210                 215                 220                 


Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr 
225                 230                 235                 240 


Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln 
                245                 250                 255     


Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser 
            260                 265                 270         


Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr 
        275                 280                 285             


Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn 
    290                 295                 300                 


Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
305                 310                 315                 320 


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
                325                 330                 335     


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
            340                 345                 350         


Ser Ala 
        


<210>  150
<211>  354
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  150

Met Ala Phe Asp Gly Thr Trp Lys Val Asp Arg Asn Glu Asn Tyr Glu 
1               5                   10                  15      


Lys Phe Met Glu Lys Met Gly Ile Asn Val Val Lys Arg Lys Leu Gly 
            20                  25                  30          


Ala His Asp Asn Leu Lys Leu Thr Ile Thr Gln Glu Gly Asn Lys Phe 
        35                  40                  45              


Thr Val Lys Glu Ser Ser Asn Phe Arg Asn Ile Asp Val Val Phe Glu 
    50                  55                  60                  


Leu Gly Val Asp Phe Ala Tyr Ser Leu Ala Asp Gly Thr Glu Leu Thr 
65                  70                  75                  80  


Val Thr Trp Thr Met Glu Gly Asn Lys Leu Val Gly Lys Phe Lys Arg 
                85                  90                  95      


Val Asp Asn Gly Lys Glu Leu Ile Ala Val Arg Glu Ile Ser Gly Asn 
            100                 105                 110         


Glu Leu Ile Gln Thr Tyr Thr Tyr Glu Val Val Glu Ala Lys Arg Ile 
        115                 120                 125             


Phe Lys Lys Glu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val 
    130                 135                 140                 


Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala 
145                 150                 155                 160 


Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr 
                165                 170                 175     


Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile 
            180                 185                 190         


Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp 
        195                 200                 205             


Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr 
    210                 215                 220                 


Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr 
225                 230                 235                 240 


Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln 
                245                 250                 255     


Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser 
            260                 265                 270         


Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr 
        275                 280                 285             


Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn 
    290                 295                 300                 


Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe 
305                 310                 315                 320 


Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly 
                325                 330                 335     


Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr 
            340                 345                 350         


Ser Ala 
        


<210>  151
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Alzheimer peptide binding protein

<400>  151
tgcaagagaa tttcccgggg cacccacg                                          28


<210>  152
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  152
agaggtaatt aaatggcatt tgatggcact tggaaagtag ac                          42


<210>  153
<211>  51
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  153
tgcaagagaa tttccacggc catcaatttc cttcttaaag atccgcttgg c                51


<210>  154
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial Sequence

<400>  154
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgggaaattc tcttgcaaaa      180

aatgtattat tcggtggaaa aggtaatgac aagctgtacg gcagtgaggg ggcagatctg      240

cttgatggtg gagaggggga tgatctcctg aaaggcggat atggtaatga tatttatcgt      300

tatctgtcag gatatggtca tcatattatt gatgatgatg gggggaaaga ggataaactc      360

agtttggctg atattgattt ccgggatgtg gccttcaagc gagaaggtaa tgacctcatc      420

atgtataaag ctgaaggtaa tgttctttcc attggtcata aaaatggtat tacattcagg      480

aactggtttg aaaaagagtc aggtgatatc tctaatcacc agatagagca gatttttgat      540

aaaagtggcc ggataatcac acctgattcc cttaaaaagg cacttgagta tcaacagcgt      600

aataataagg caagttatgt gtatgggaat gatgcattag cctatggaag tcagggtgat      660

cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtag cttcgatgtt      720

aaagaggaaa gaactgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      780

tatggacgga actcaataac cctgaccaca tcagca                                816


<210>  155
<211>  38
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  AGAGGTAATTAAATGGATGCGGAATTTCGCCATGATAG

<400>  155
agaggtaatt aaatggatgc ggaatttcgc catgatag                               38


<210>  156
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TGCAAGAGAATTTCCCGCGATCACCACGCCG

<400>  156
tgcaagagaa tttcccgcga tcaccacgcc g                                      31


<210>  157
<211>  1024
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 282, NO. 43, pp. 3147731483

<400>  157

Met Thr Thr Ile Thr Thr Ala Gln Ile Lys Ser Thr Leu Gln Ser Ala 
1               5                   10                  15      


Lys Gln Ser Ala Ala Asn Lys Leu His Ser Ala Gly Gln Ser Thr Lys 
            20                  25                  30          


Asp Ala Leu Lys Lys Ala Ala Glu Gln Thr Arg Asn Ala Gly Asn Arg 
        35                  40                  45              


Leu Ile Leu Leu Ile Pro Lys Asp Tyr Lys Gly Gln Gly Ser Ser Leu 
    50                  55                  60                  


Asn Asp Leu Val Arg Thr Ala Asp Glu Leu Gly Ile Glu Val Gln Tyr 
65                  70                  75                  80  


Asp Glu Lys Asn Gly Thr Ala Ile Thr Lys Gln Val Phe Gly Thr Ala 
                85                  90                  95      


Glu Lys Leu Ile Gly Leu Thr Glu Arg Gly Val Thr Ile Phe Ala Pro 
            100                 105                 110         


Gln Leu Asp Lys Leu Leu Gln Lys Tyr Gln Lys Ala Gly Asn Ile Leu 
        115                 120                 125             


Gly Gly Gly Ala Glu Asn Ile Gly Asp Asn Leu Gly Lys Ala Gly Gly 
    130                 135                 140                 


Ile Leu Ser Thr Phe Gln Asn Phe Leu Gly Thr Ala Leu Ser Ser Met 
145                 150                 155                 160 


Lys Ile Asp Glu Leu Ile Lys Lys Gln Lys Ser Gly Gly Asn Val Ser 
                165                 170                 175     


Ser Ser Glu Met Ala Glu Ala Ser Ile Glu Leu Ile Asn Gln Leu Val 
            180                 185                 190         


Asp Thr Val Ala Ser Leu Asn Asn Asn Val Asn Ser Phe Ser Gln Gln 
        195                 200                 205             


Leu Asn Thr Leu Gly Ser Val Leu Ser Asn Thr Lys His Leu Asn Gly 
    210                 215                 220                 


Val Gly Asn Lys Leu Gln Asn Leu Pro Asn Leu Asp Asn Ile Gly Ala 
225                 230                 235                 240 


Gly Leu Asp Thr Val Ser Gly Ile Leu Ser Ala Ile Ser Ala Ser Phe 
                245                 250                 255     


Ile Leu Ser Asn Ala Asp Ala Asp Thr Arg Thr Lys Ala Ala Ala Gly 
            260                 265                 270         


Val Glu Leu Thr Thr Lys Val Leu Gly Asn Val Gly Lys Gly Ile Ser 
        275                 280                 285             


Gln Tyr Ile Ile Ala Gln Arg Ala Ala Gln Gly Leu Ser Thr Ser Ala 
    290                 295                 300                 


Ala Ala Ala Gly Leu Ile Ala Ser Ala Val Thr Leu Ala Ile Ser Pro 
305                 310                 315                 320 


Leu Ser Phe Leu Ser Ile Ala Asp Lys Phe Lys Arg Ala Asn Lys Ile 
                325                 330                 335     


Glu Glu Tyr Ser Gln Arg Phe Lys Lys Leu Gly Tyr Asp Gly Asp Ser 
            340                 345                 350         


Leu Leu Ala Ala Phe His Lys Glu Thr Gly Ala Ile Asp Ala Ser Leu 
        355                 360                 365             


Thr Thr Ile Ser Thr Val Leu Ala Ser Val Ser Ser Gly Ile Ser Ala 
    370                 375                 380                 


Ala Ala Thr Thr Ser Leu Val Gly Ala Pro Val Ser Ala Leu Val Gly 
385                 390                 395                 400 


Ala Val Thr Gly Ile Ile Ser Gly Ile Leu Glu Ala Ser Lys Gln Ala 
                405                 410                 415     


Met Phe Glu His Val Ala Ser Lys Met Ala Asp Val Ile Ala Glu Trp 
            420                 425                 430         


Glu Lys Lys His Gly Lys Asn Tyr Phe Glu Asn Gly Tyr Asp Ala Arg 
        435                 440                 445             


His Ala Ala Phe Leu Glu Asp Asn Phe Lys Ile Leu Ser Gln Tyr Asn 
    450                 455                 460                 


Lys Glu Tyr Ser Val Glu Arg Ser Val Leu Ile Thr Gln Gln His Trp 
465                 470                 475                 480 


Asp Thr Leu Ile Gly Glu Leu Ala Gly Val Thr Arg Asn Gly Asp Lys 
                485                 490                 495     


Thr Leu Ser Gly Lys Ser Tyr Ile Asp Tyr Tyr Glu Glu Gly Lys Arg 
            500                 505                 510         


Leu Glu Lys Lys Pro Asp Glu Phe Gln Lys Gln Val Phe Asp Pro Leu 
        515                 520                 525             


Lys Gly Asn Ile Asp Leu Ser Asp Ser Lys Ser Ser Thr Leu Leu Lys 
    530                 535                 540                 


Phe Val Thr Pro Leu Leu Thr Pro Gly Glu Glu Ile Arg Glu Arg Arg 
545                 550                 555                 560 


Gln Ser Gly Lys Tyr Glu Tyr Ile Thr Glu Leu Leu Val Lys Gly Val 
                565                 570                 575     


Asp Lys Trp Thr Val Lys Gly Val Gln Asp Lys Gly Ala Val Tyr Asp 
            580                 585                 590         


Tyr Ser Asn Leu Ile Gln His Ala Ser Val Gly Asn Asn Gln Tyr Arg 
        595                 600                 605             


Glu Ile Arg Ile Glu Ser His Leu Gly Asp Gly Asp Asp Lys Val Phe 
    610                 615                 620                 


Leu Ser Ala Gly Ser Ala Asn Ile Tyr Ala Gly Lys Gly His Asp Val 
625                 630                 635                 640 


Val Tyr Tyr Asp Lys Thr Asp Thr Gly Tyr Leu Thr Ile Asp Gly Thr 
                645                 650                 655     


Lys Ala Thr Glu Ala Gly Asn Tyr Thr Val Thr Arg Val Leu Gly Gly 
            660                 665                 670         


Asp Val Lys Val Leu Gln Glu Val Val Lys Glu Gln Glu Val Ser Val 
        675                 680                 685             


Gly Lys Arg Thr Glu Lys Thr Gln Tyr Arg Ser Tyr Glu Phe Thr His 
    690                 695                 700                 


Ile Asn Gly Lys Asn Leu Thr Glu Thr Asp Asn Leu Tyr Ser Val Glu 
705                 710                 715                 720 


Glu Leu Ile Gly Thr Thr Arg Ala Asp Lys Phe Phe Gly Ser Lys Phe 
                725                 730                 735     


Thr Asp Ile Phe His Gly Ala Asp Gly Asp Asp Leu Ile Glu Gly Asn 
            740                 745                 750         


Asp Gly Asn Asp Arg Leu Tyr Gly Asp Lys Gly Asn Asp Thr Leu Ser 
        755                 760                 765             


Gly Gly Asn Gly Asp Asp Gln Leu Tyr Gly Gly Asp Gly Asn Asp Lys 
    770                 775                 780                 


Leu Ile Gly Gly Ala Gly Asn Asn Tyr Leu Asn Gly Gly Asp Gly Asp 
785                 790                 795                 800 


Asp Glu Leu Gln Val Gln Gly Asn Ser Leu Ala Lys Asn Val Leu Phe 
                805                 810                 815     


Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu 
            820                 825                 830         


Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn 
        835                 840                 845             


Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp 
    850                 855                 860                 


Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg 
865                 870                 875                 880 


Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala 
                885                 890                 895     


Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg 
            900                 905                 910         


Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu 
        915                 920                 925             


Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys 
    930                 935                 940                 


Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr 
945                 950                 955                 960 


Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu 
                965                 970                 975     


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val 
            980                 985                 990         


Lys Glu Glu Arg Thr Ala Ala Ser  Leu Leu Gln Leu Ser  Gly Asn Ala 
        995                 1000                 1005             


Ser Asp  Phe Ser Tyr Gly Arg  Asn Ser Ile Thr Leu  Thr Thr Ser 
    1010                 1015                 1020             


Ala 
    


<210>  158
<211>  513
<212>  DNA
<213>  Escherichia coli

<400>  158
atgaatataa acaaaccatt agagattctt gggcatgtat cctggctatg ggccagttct       60

ccactacaca gaaactggcc agtatctttg tttgcaataa atgtattacc cgcaatacag      120

gctaaccaat atgttttatt aacccgggat gattaccctg tcgcgtattg tagttgggct      180

aatttaagtt tagaaaatga aattaaatat cttaatgatg ttacctcatt agttgcagaa      240

gactggactt caggtgatcg taaatggttc attgactgga ttgctccttt cggggataac      300

ggtgccctgt acaaatatat gcgaaaaaaa ttccctgatg aactattcag agccatcagg      360

gtggatccca aaactcatgt tggtaaagta tcagaatttc atggaggtaa aattgataaa      420

cagttagcga ataaaatttt taaacaatat caccacgagt taataactga agtaaaaaga      480

aagtcagatt ttaatttttc attaactggt taa                                   513


<210>  159
<211>  524
<212>  DNA
<213>  Escherichia coli

<400>  159
atgaatataa acaaaccatt agagattctt gggcatgtat cctggctatg ggccagttct       60

ccactacaca gaaactggcc agtatctttg tttgcaataa atgtattacc cgcaatacag      120

gctaaccaat atgctttatt aatccgggat gattaccctg tcgcgtattg tagttgggct      180

aatttaagtt tggaaaatga aattaaatat cttaatgatg ttacctcatt agttgcagaa      240

gactggactt caggtgatcg taaatggttc attgactgga ttgctccttt cggggataac      300

ggtgccctgt acaaatatat gcgaaaaaaa ttccctgatg aactattcag agccatcagg      360

gtggatccca aaactcatgt tggtaaagta tcagaatttc atggaggtaa aattgataaa      420

cagttagcga ataaaatttt taaacaatat caccacgagt taataactga agtaaaaaga      480

aagtcagatt ttaatttttc attaactggt taagaggtaa ttaa                       524


<210>  160
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Primer elongation sequence for cloning into pSU HlyA1 vector

<400>  160
agaggtaatt aaatg                                                        15


<210>  161
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Primer elongation sequence for cloning into pSU HlyA1 vector

<400>  161
tgcaagagaa tttcc                                                        15


<210>  162
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  162
gctcgaattc gtaatcatg                                                    19


<210>  163
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  163
attaaatggg aaattctctt gc                                                22


<210>  164
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  164
gtaattaaat gggaaattct cttg                                              24


<210>  165
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  165
ggttaagagg taattaaatg gg                                                22


<210>  166
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  166
ttaactggtt aagaggtaat taaatg                                            26


<210>  167
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  167
aatttttcat taactggtta agag                                              24


<210>  168
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  168
tcagatttta atttttcatt aactgg                                            26


<210>  169
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  169
ataactgaag taaaaagaaa gtca                                              24


<210>  170
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  170
aaacaatatc accacgagtt a                                                 21


<210>  171
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  171
cagttagcga ataaaatttt taaac                                             25


<210>  172
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide Primer

<400>  172
atgattacga attcgagctc ccaa                                              24


<210>  173
<211>  14
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  173
ccaacgcgcg ggga                                                         14


<210>  174
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  174
caggaaacag ctatgacatt attacgaatt cgagcatgg                              39


<210>  175
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  175
ccatgctcga attcgtaata atgtcatagc tgtttcctg                              39


<210>  176
<211>  4386
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  176
tgattacgaa ttcgagcatg ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag       60

gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga gagggggatg      120

atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga tatggtcatc      180

atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat attgatttcc      240

gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct gaaggtaatg      300

ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa aaagagtcag      360

gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg ataatcacac      420

ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca agttatgtgt      480

atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta attaatgaaa      540

tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga actgcagctt      600

ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac tcaataaccc      660

tgaccacatc agcataatat attaatttaa atgatagcaa tcttactggg ctgtgccaca      720

taagattgct attttttttg gagtcataat ggattcttgt cataaaattg attatgggtt      780

atacgccctg gagattttag cccaatacca taacgtctct gttaacccgg aagaaattaa      840

acatagattt gatacagacg ggacaggtct gggattaacg tcatggttgc ttgctgcgaa      900

atctttagaa ctaaaggtaa aacaggtaaa aaaaacaatt gatcgatgat aagctgtcaa      960

acatgagaat tacaacttat atcgtatggg gctgacttca ggtgctacat ttgaagagat     1020

aaattgcact gaaatcctgc aggcatgcaa gcttggcact ggccgtcgtt ttacaacgtc     1080

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     1140

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     1200

tgaatggcga atgccgttaa cggattcttg aagacgaaag ggcctcgtga tacgcctatt     1260

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     1320

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     1380

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     1440

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     1500

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     1560

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     1620

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     1680

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     1740

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     1800

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     1860

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     1920

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     1980

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     2040

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     2100

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     2160

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     2220

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     2280

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     2340

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     2400

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     2460

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     2520

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     2580

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     2640

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     2700

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     2760

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     2820

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     2880

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     2940

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     3000

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     3060

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     3120

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     3180

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgcct     3240

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     3300

cagtacaatc tgctctgatg ccgcatagtt aagccagtat acactccgct atcgctacgt     3360

gactgggtca tggctgcgcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     3420

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     3480

cagaggtttt caccgtcatc accgaaacgc gcgaggcagc tgcggtaaag ctcatcagcg     3540

tggtcgtgaa gcgattcaca gatgtctgcc tgttcatccg cgtccagctc gttgagtttc     3600

tccagaagcg ttaatgtctg gcttctgata aagcgggcca tgttaagggc ggttttttcc     3660

tgtttggtca ctgatgcctc cgtgtaaggg ggatttctgt tcatgggggt aatgataccg     3720

atgaaacgag agaggatgct cacgatacgg gttactgatg atgaacatgc ccggttactg     3780

gaacgttgtg agggtaaaca actggcggta tggatgcggc gggaccagag aaaaatcact     3840

cagggtcaat gccagcgctt cgttaataca gatgtaggtg ttccacaggg tagccagcag     3900

catcctgcga tgcagatccg gaacataatg gtgcagggcg ctgacttccg cgtttccaga     3960

ctttacgaaa cacggaaacc gaagaccatt catgttgttg ctcaggtcgc agacgttttg     4020

cagcagcagt cgcttcacgt tcgctcgcgt atcggtgatt cattctgcta accagtaagg     4080

caaccccgcc agcctagccg ggtcctcaac gacaggagca cgatcatgcg cacccgtggc     4140

caggacccaa cgctgcccgc cgttaacggc caatacgcaa accgcctctc cccgcgcgtt     4200

ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc     4260

gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc     4320

ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct     4380

atgaca                                                                4386


<210>  177
<211>  4386
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  177
ttattacgaa ttcgagcatg ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag       60

gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga gagggggatg      120

atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga tatggtcatc      180

atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat attgatttcc      240

gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct gaaggtaatg      300

ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa aaagagtcag      360

gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg ataatcacac      420

ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca agttatgtgt      480

atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta attaatgaaa      540

tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga actgcagctt      600

ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac tcaataaccc      660

tgaccacatc agcataatat attaatttaa atgatagcaa tcttactggg ctgtgccaca      720

taagattgct attttttttg gagtcataat ggattcttgt cataaaattg attatgggtt      780

atacgccctg gagattttag cccaatacca taacgtctct gttaacccgg aagaaattaa      840

acatagattt gatacagacg ggacaggtct gggattaacg tcatggttgc ttgctgcgaa      900

atctttagaa ctaaaggtaa aacaggtaaa aaaaacaatt gatcgatgat aagctgtcaa      960

acatgagaat tacaacttat atcgtatggg gctgacttca ggtgctacat ttgaagagat     1020

aaattgcact gaaatcctgc aggcatgcaa gcttggcact ggccgtcgtt ttacaacgtc     1080

gtgactggga aaaccctggc gttacccaac ttaatcgcct tgcagcacat ccccctttcg     1140

ccagctggcg taatagcgaa gaggcccgca ccgatcgccc ttcccaacag ttgcgcagcc     1200

tgaatggcga atgccgttaa cggattcttg aagacgaaag ggcctcgtga tacgcctatt     1260

tttataggtt aatgtcatga taataatggt ttcttagacg tcaggtggca cttttcgggg     1320

aaatgtgcgc ggaaccccta tttgtttatt tttctaaata cattcaaata tgtatccgct     1380

catgagacaa taaccctgat aaatgcttca ataatattga aaaaggaaga gtatgagtat     1440

tcaacatttc cgtgtcgccc ttattccctt ttttgcggca ttttgccttc ctgtttttgc     1500

tcacccagaa acgctggtga aagtaaaaga tgctgaagat cagttgggtg cacgagtggg     1560

ttacatcgaa ctggatctca acagcggtaa gatccttgag agttttcgcc ccgaagaacg     1620

ttttccaatg atgagcactt ttaaagttct gctatgtggc gcggtattat cccgtattga     1680

cgccgggcaa gagcaactcg gtcgccgcat acactattct cagaatgact tggttgagta     1740

ctcaccagtc acagaaaagc atcttacgga tggcatgaca gtaagagaat tatgcagtgc     1800

tgccataacc atgagtgata acactgcggc caacttactt ctgacaacga tcggaggacc     1860

gaaggagcta accgcttttt tgcacaacat gggggatcat gtaactcgcc ttgatcgttg     1920

ggaaccggag ctgaatgaag ccataccaaa cgacgagcgt gacaccacga tgcctgtagc     1980

aatggcaaca acgttgcgca aactattaac tggcgaacta cttactctag cttcccggca     2040

acaattaata gactggatgg aggcggataa agttgcagga ccacttctgc gctcggccct     2100

tccggctggc tggtttattg ctgataaatc tggagccggt gagcgtgggt ctcgcggtat     2160

cattgcagca ctggggccag atggtaagcc ctcccgtatc gtagttatct acacgacggg     2220

gagtcaggca actatggatg aacgaaatag acagatcgct gagataggtg cctcactgat     2280

taagcattgg taactgtcag accaagttta ctcatatata ctttagattg atttaaaact     2340

tcatttttaa tttaaaagga tctaggtgaa gatccttttt gataatctca tgaccaaaat     2400

cccttaacgt gagttttcgt tccactgagc gtcagacccc gtagaaaaga tcaaaggatc     2460

ttcttgagat cctttttttc tgcgcgtaat ctgctgcttg caaacaaaaa aaccaccgct     2520

accagcggtg gtttgtttgc cggatcaaga gctaccaact ctttttccga aggtaactgg     2580

cttcagcaga gcgcagatac caaatactgt ccttctagtg tagccgtagt taggccacca     2640

cttcaagaac tctgtagcac cgcctacata cctcgctctg ctaatcctgt taccagtggc     2700

tgctgccagt ggcgataagt cgtgtcttac cgggttggac tcaagacgat agttaccgga     2760

taaggcgcag cggtcgggct gaacgggggg ttcgtgcaca cagcccagct tggagcgaac     2820

gacctacacc gaactgagat acctacagcg tgagctatga gaaagcgcca cgcttcccga     2880

agggagaaag gcggacaggt atccggtaag cggcagggtc ggaacaggag agcgcacgag     2940

ggagcttcca gggggaaacg cctggtatct ttatagtcct gtcgggtttc gccacctctg     3000

acttgagcgt cgatttttgt gatgctcgtc aggggggcgg agcctatgga aaaacgccag     3060

caacgcggcc tttttacggt tcctggcctt ttgctggcct tttgctcaca tgttctttcc     3120

tgcgttatcc cctgattctg tggataaccg tattaccgcc tttgagtgag ctgataccgc     3180

tcgccgcagc cgaacgaccg agcgcagcga gtcagtgagc gaggaagcgg aagagcgcct     3240

gatgcggtat tttctcctta cgcatctgtg cggtatttca caccgcatat ggtgcactct     3300

cagtacaatc tgctctgatg ccgcatagtt aagccagtat acactccgct atcgctacgt     3360

gactgggtca tggctgcgcc ccgacacccg ccaacacccg ctgacgcgcc ctgacgggct     3420

tgtctgctcc cggcatccgc ttacagacaa gctgtgaccg tctccgggag ctgcatgtgt     3480

cagaggtttt caccgtcatc accgaaacgc gcgaggcagc tgcggtaaag ctcatcagcg     3540

tggtcgtgaa gcgattcaca gatgtctgcc tgttcatccg cgtccagctc gttgagtttc     3600

tccagaagcg ttaatgtctg gcttctgata aagcgggcca tgttaagggc ggttttttcc     3660

tgtttggtca ctgatgcctc cgtgtaaggg ggatttctgt tcatgggggt aatgataccg     3720

atgaaacgag agaggatgct cacgatacgg gttactgatg atgaacatgc ccggttactg     3780

gaacgttgtg agggtaaaca actggcggta tggatgcggc gggaccagag aaaaatcact     3840

cagggtcaat gccagcgctt cgttaataca gatgtaggtg ttccacaggg tagccagcag     3900

catcctgcga tgcagatccg gaacataatg gtgcagggcg ctgacttccg cgtttccaga     3960

ctttacgaaa cacggaaacc gaagaccatt catgttgttg ctcaggtcgc agacgttttg     4020

cagcagcagt cgcttcacgt tcgctcgcgt atcggtgatt cattctgcta accagtaagg     4080

caaccccgcc agcctagccg ggtcctcaac gacaggagca cgatcatgcg cacccgtggc     4140

caggacccaa cgctgcccgc cgttaacggc caatacgcaa accgcctctc cccgcgcgtt     4200

ggccgattca ttaatgcagc tggcacgaca ggtttcccga ctggaaagcg ggcagtgagc     4260

gcaacgcaat taatgtgagt tagctcactc attaggcacc ccaggcttta cactttatgc     4320

ttccggctcg tatgttgtgt ggaattgtga gcggataaca atttcacaca ggaaacagct     4380

atgaca                                                                4386


<210>  178
<211>  4391
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  178
tgattacgaa ttcgagcatt aaatgggaaa ttctcttgca aaaaatgtat tattcggtgg       60

aaaaggtaat gacaagctgt acggcagtga gggggcagat ctgcttgatg gtggagaggg      120

ggatgatctc ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg      180

tcatcatatt attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga      240

tttccgggat gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg      300

taatgttctt tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga      360

gtcaggtgat atctctaatc accagataga gcagattttt gataaaagtg gccggataat      420

cacacctgat tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta      480

tgtgtatggg aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa      540

tgaaatcagc aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc      600

agcttcttta ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat      660

aaccctgacc acatcagcat aatatattaa tttaaatgat agcaatctta ctgggctgtg      720

ccacataaga ttgctatttt ttttggagtc ataatggatt cttgtcataa aattgattat      780

gggttatacg ccctggagat tttagcccaa taccataacg tctctgttaa cccggaagaa      840

attaaacata gatttgatac agacgggaca ggtctgggat taacgtcatg gttgcttgct      900

gcgaaatctt tagaactaaa ggtaaaacag gtaaaaaaaa caattgatcg atgataagct      960

gtcaaacatg agaattacaa cttatatcgt atggggctga cttcaggtgc tacatttgaa     1020

gagataaatt gcactgaaat cctgcaggca tgcaagcttg gcactggccg tcgttttaca     1080

acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag cacatccccc     1140

tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc aacagttgcg     1200

cagcctgaat ggcgaatgcc gttaacggat tcttgaagac gaaagggcct cgtgatacgc     1260

ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg tggcactttt     1320

cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc aaatatgtat     1380

ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag gaagagtatg     1440

agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg ccttcctgtt     1500

tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt gggtgcacga     1560

gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt tcgccccgaa     1620

gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt attatcccgt     1680

attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa tgacttggtt     1740

gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag agaattatgc     1800

agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac aacgatcgga     1860

ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac tcgccttgat     1920

cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac cacgatgcct     1980

gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac tctagcttcc     2040

cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact tctgcgctcg     2100

gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg tgggtctcgc     2160

ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt tatctacacg     2220

acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat aggtgcctca     2280

ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta gattgattta     2340

aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa tctcatgacc     2400

aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga aaagatcaaa     2460

ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac aaaaaaacca     2520

ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt tccgaaggta     2580

actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc gtagttaggc     2640

caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat cctgttacca     2700

gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag acgatagtta     2760

ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc cagcttggag     2820

cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag cgccacgctt     2880

cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac aggagagcgc     2940

acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg gtttcgccac     3000

ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct atggaaaaac     3060

gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc tcacatgttc     3120

tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga gtgagctgat     3180

accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga agcggaagag     3240

cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg catatggtgc     3300

actctcagta caatctgctc tgatgccgca tagttaagcc agtatacact ccgctatcgc     3360

tacgtgactg ggtcatggct gcgccccgac acccgccaac acccgctgac gcgccctgac     3420

gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc gggagctgca     3480

tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg taaagctcat     3540

cagcgtggtc gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc agctcgttga     3600

gtttctccag aagcgttaat gtctggcttc tgataaagcg ggccatgtta agggcggttt     3660

tttcctgttt ggtcactgat gcctccgtgt aagggggatt tctgttcatg ggggtaatga     3720

taccgatgaa acgagagagg atgctcacga tacgggttac tgatgatgaa catgcccggt     3780

tactggaacg ttgtgagggt aaacaactgg cggtatggat gcggcgggac cagagaaaaa     3840

tcactcaggg tcaatgccag cgcttcgtta atacagatgt aggtgttcca cagggtagcc     3900

agcagcatcc tgcgatgcag atccggaaca taatggtgca gggcgctgac ttccgcgttt     3960

ccagacttta cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag gtcgcagacg     4020

ttttgcagca gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc tgctaaccag     4080

taaggcaacc ccgccagcct agccgggtcc tcaacgacag gagcacgatc atgcgcaccc     4140

gtggccagga cccaacgctg cccgccgtta acggccaata cgcaaaccgc ctctccccgc     4200

gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga aagcgggcag     4260

tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg ctttacactt     4320

tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc acacaggaaa     4380

cagctatgac a                                                          4391


<210>  179
<211>  4394
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  179
tgattacgaa ttcgagcgta attaaatggg aaattctctt gcaaaaaatg tattattcgg       60

tggaaaaggt aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga      120

gggggatgat ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata      180

tggtcatcat attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat      240

tgatttccgg gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga      300

aggtaatgtt ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa      360

agagtcaggt gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat      420

aatcacacct gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag      480

ttatgtgtat gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat      540

taatgaaatc agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac      600

tgcagcttct ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc      660

aataaccctg accacatcag cataatatat taatttaaat gatagcaatc ttactgggct      720

gtgccacata agattgctat tttttttgga gtcataatgg attcttgtca taaaattgat      780

tatgggttat acgccctgga gattttagcc caataccata acgtctctgt taacccggaa      840

gaaattaaac atagatttga tacagacggg acaggtctgg gattaacgtc atggttgctt      900

gctgcgaaat ctttagaact aaaggtaaaa caggtaaaaa aaacaattga tcgatgataa      960

gctgtcaaac atgagaatta caacttatat cgtatggggc tgacttcagg tgctacattt     1020

gaagagataa attgcactga aatcctgcag gcatgcaagc ttggcactgg ccgtcgtttt     1080

acaacgtcgt gactgggaaa accctggcgt tacccaactt aatcgccttg cagcacatcc     1140

ccctttcgcc agctggcgta atagcgaaga ggcccgcacc gatcgccctt cccaacagtt     1200

gcgcagcctg aatggcgaat gccgttaacg gattcttgaa gacgaaaggg cctcgtgata     1260

cgcctatttt tataggttaa tgtcatgata ataatggttt cttagacgtc aggtggcact     1320

tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca ttcaaatatg     1380

tatccgctca tgagacaata accctgataa atgcttcaat aatattgaaa aaggaagagt     1440

atgagtattc aacatttccg tgtcgccctt attccctttt ttgcggcatt ttgccttcct     1500

gtttttgctc acccagaaac gctggtgaaa gtaaaagatg ctgaagatca gttgggtgca     1560

cgagtgggtt acatcgaact ggatctcaac agcggtaaga tccttgagag ttttcgcccc     1620

gaagaacgtt ttccaatgat gagcactttt aaagttctgc tatgtggcgc ggtattatcc     1680

cgtattgacg ccgggcaaga gcaactcggt cgccgcatac actattctca gaatgacttg     1740

gttgagtact caccagtcac agaaaagcat cttacggatg gcatgacagt aagagaatta     1800

tgcagtgctg ccataaccat gagtgataac actgcggcca acttacttct gacaacgatc     1860

ggaggaccga aggagctaac cgcttttttg cacaacatgg gggatcatgt aactcgcctt     1920

gatcgttggg aaccggagct gaatgaagcc ataccaaacg acgagcgtga caccacgatg     1980

cctgtagcaa tggcaacaac gttgcgcaaa ctattaactg gcgaactact tactctagct     2040

tcccggcaac aattaataga ctggatggag gcggataaag ttgcaggacc acttctgcgc     2100

tcggcccttc cggctggctg gtttattgct gataaatctg gagccggtga gcgtgggtct     2160

cgcggtatca ttgcagcact ggggccagat ggtaagccct cccgtatcgt agttatctac     2220

acgacgggga gtcaggcaac tatggatgaa cgaaatagac agatcgctga gataggtgcc     2280

tcactgatta agcattggta actgtcagac caagtttact catatatact ttagattgat     2340

ttaaaacttc atttttaatt taaaaggatc taggtgaaga tcctttttga taatctcatg     2400

accaaaatcc cttaacgtga gttttcgttc cactgagcgt cagaccccgt agaaaagatc     2460

aaaggatctt cttgagatcc tttttttctg cgcgtaatct gctgcttgca aacaaaaaaa     2520

ccaccgctac cagcggtggt ttgtttgccg gatcaagagc taccaactct ttttccgaag     2580

gtaactggct tcagcagagc gcagatacca aatactgtcc ttctagtgta gccgtagtta     2640

ggccaccact tcaagaactc tgtagcaccg cctacatacc tcgctctgct aatcctgtta     2700

ccagtggctg ctgccagtgg cgataagtcg tgtcttaccg ggttggactc aagacgatag     2760

ttaccggata aggcgcagcg gtcgggctga acggggggtt cgtgcacaca gcccagcttg     2820

gagcgaacga cctacaccga actgagatac ctacagcgtg agctatgaga aagcgccacg     2880

cttcccgaag ggagaaaggc ggacaggtat ccggtaagcg gcagggtcgg aacaggagag     2940

cgcacgaggg agcttccagg gggaaacgcc tggtatcttt atagtcctgt cgggtttcgc     3000

cacctctgac ttgagcgtcg atttttgtga tgctcgtcag gggggcggag cctatggaaa     3060

aacgccagca acgcggcctt tttacggttc ctggcctttt gctggccttt tgctcacatg     3120

ttctttcctg cgttatcccc tgattctgtg gataaccgta ttaccgcctt tgagtgagct     3180

gataccgctc gccgcagccg aacgaccgag cgcagcgagt cagtgagcga ggaagcggaa     3240

gagcgcctga tgcggtattt tctccttacg catctgtgcg gtatttcaca ccgcatatgg     3300

tgcactctca gtacaatctg ctctgatgcc gcatagttaa gccagtatac actccgctat     3360

cgctacgtga ctgggtcatg gctgcgcccc gacacccgcc aacacccgct gacgcgccct     3420

gacgggcttg tctgctcccg gcatccgctt acagacaagc tgtgaccgtc tccgggagct     3480

gcatgtgtca gaggttttca ccgtcatcac cgaaacgcgc gaggcagctg cggtaaagct     3540

catcagcgtg gtcgtgaagc gattcacaga tgtctgcctg ttcatccgcg tccagctcgt     3600

tgagtttctc cagaagcgtt aatgtctggc ttctgataaa gcgggccatg ttaagggcgg     3660

ttttttcctg tttggtcact gatgcctccg tgtaaggggg atttctgttc atgggggtaa     3720

tgataccgat gaaacgagag aggatgctca cgatacgggt tactgatgat gaacatgccc     3780

ggttactgga acgttgtgag ggtaaacaac tggcggtatg gatgcggcgg gaccagagaa     3840

aaatcactca gggtcaatgc cagcgcttcg ttaatacaga tgtaggtgtt ccacagggta     3900

gccagcagca tcctgcgatg cagatccgga acataatggt gcagggcgct gacttccgcg     3960

tttccagact ttacgaaaca cggaaaccga agaccattca tgttgttgct caggtcgcag     4020

acgttttgca gcagcagtcg cttcacgttc gctcgcgtat cggtgattca ttctgctaac     4080

cagtaaggca accccgccag cctagccggg tcctcaacga caggagcacg atcatgcgca     4140

cccgtggcca ggacccaacg ctgcccgccg ttaacggcca atacgcaaac cgcctctccc     4200

cgcgcgttgg ccgattcatt aatgcagctg gcacgacagg tttcccgact ggaaagcggg     4260

cagtgagcgc aacgcaatta atgtgagtta gctcactcat taggcacccc aggctttaca     4320

ctttatgctt ccggctcgta tgttgtgtgg aattgtgagc ggataacaat ttcacacagg     4380

aaacagctat gaca                                                       4394


<210>  180
<211>  4397
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  180
tgattacgaa ttcgagcgag gtaattaaat gggaaattct cttgcaaaaa atgtattatt       60

cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg gcagatctgc ttgatggtgg      120

agagggggat gatctcctga aaggcggata tggtaatgat atttatcgtt atctgtcagg      180

atatggtcat catattattg atgatgatgg ggggaaagag gataaactca gtttggctga      240

tattgatttc cgggatgtgg ccttcaagcg agaaggtaat gacctcatca tgtataaagc      300

tgaaggtaat gttctttcca ttggtcataa aaatggtatt acattcagga actggtttga      360

aaaagagtca ggtgatatct ctaatcacca gatagagcag atttttgata aaagtggccg      420

gataatcaca cctgattccc ttaaaaaggc acttgagtat caacagcgta ataataaggc      480

aagttatgtg tatgggaatg atgcattagc ctatggaagt cagggtgatc ttaatccatt      540

aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc ttcgatgtta aagaggaaag      600

aactgcagct tctttattgc agttgtccgg taatgccagt gatttttcat atggacggaa      660

ctcaataacc ctgaccacat cagcataata tattaattta aatgatagca atcttactgg      720

gctgtgccac ataagattgc tatttttttt ggagtcataa tggattcttg tcataaaatt      780

gattatgggt tatacgccct ggagatttta gcccaatacc ataacgtctc tgttaacccg      840

gaagaaatta aacatagatt tgatacagac gggacaggtc tgggattaac gtcatggttg      900

cttgctgcga aatctttaga actaaaggta aaacaggtaa aaaaaacaat tgatcgatga      960

taagctgtca aacatgagaa ttacaactta tatcgtatgg ggctgacttc aggtgctaca     1020

tttgaagaga taaattgcac tgaaatcctg caggcatgca agcttggcac tggccgtcgt     1080

tttacaacgt cgtgactggg aaaaccctgg cgttacccaa cttaatcgcc ttgcagcaca     1140

tccccctttc gccagctggc gtaatagcga agaggcccgc accgatcgcc cttcccaaca     1200

gttgcgcagc ctgaatggcg aatgccgtta acggattctt gaagacgaaa gggcctcgtg     1260

atacgcctat ttttataggt taatgtcatg ataataatgg tttcttagac gtcaggtggc     1320

acttttcggg gaaatgtgcg cggaacccct atttgtttat ttttctaaat acattcaaat     1380

atgtatccgc tcatgagaca ataaccctga taaatgcttc aataatattg aaaaaggaag     1440

agtatgagta ttcaacattt ccgtgtcgcc cttattccct tttttgcggc attttgcctt     1500

cctgtttttg ctcacccaga aacgctggtg aaagtaaaag atgctgaaga tcagttgggt     1560

gcacgagtgg gttacatcga actggatctc aacagcggta agatccttga gagttttcgc     1620

cccgaagaac gttttccaat gatgagcact tttaaagttc tgctatgtgg cgcggtatta     1680

tcccgtattg acgccgggca agagcaactc ggtcgccgca tacactattc tcagaatgac     1740

ttggttgagt actcaccagt cacagaaaag catcttacgg atggcatgac agtaagagaa     1800

ttatgcagtg ctgccataac catgagtgat aacactgcgg ccaacttact tctgacaacg     1860

atcggaggac cgaaggagct aaccgctttt ttgcacaaca tgggggatca tgtaactcgc     1920

cttgatcgtt gggaaccgga gctgaatgaa gccataccaa acgacgagcg tgacaccacg     1980

atgcctgtag caatggcaac aacgttgcgc aaactattaa ctggcgaact acttactcta     2040

gcttcccggc aacaattaat agactggatg gaggcggata aagttgcagg accacttctg     2100

cgctcggccc ttccggctgg ctggtttatt gctgataaat ctggagccgg tgagcgtggg     2160

tctcgcggta tcattgcagc actggggcca gatggtaagc cctcccgtat cgtagttatc     2220

tacacgacgg ggagtcaggc aactatggat gaacgaaata gacagatcgc tgagataggt     2280

gcctcactga ttaagcattg gtaactgtca gaccaagttt actcatatat actttagatt     2340

gatttaaaac ttcattttta atttaaaagg atctaggtga agatcctttt tgataatctc     2400

atgaccaaaa tcccttaacg tgagttttcg ttccactgag cgtcagaccc cgtagaaaag     2460

atcaaaggat cttcttgaga tccttttttt ctgcgcgtaa tctgctgctt gcaaacaaaa     2520

aaaccaccgc taccagcggt ggtttgtttg ccggatcaag agctaccaac tctttttccg     2580

aaggtaactg gcttcagcag agcgcagata ccaaatactg tccttctagt gtagccgtag     2640

ttaggccacc acttcaagaa ctctgtagca ccgcctacat acctcgctct gctaatcctg     2700

ttaccagtgg ctgctgccag tggcgataag tcgtgtctta ccgggttgga ctcaagacga     2760

tagttaccgg ataaggcgca gcggtcgggc tgaacggggg gttcgtgcac acagcccagc     2820

ttggagcgaa cgacctacac cgaactgaga tacctacagc gtgagctatg agaaagcgcc     2880

acgcttcccg aagggagaaa ggcggacagg tatccggtaa gcggcagggt cggaacagga     2940

gagcgcacga gggagcttcc agggggaaac gcctggtatc tttatagtcc tgtcgggttt     3000

cgccacctct gacttgagcg tcgatttttg tgatgctcgt caggggggcg gagcctatgg     3060

aaaaacgcca gcaacgcggc ctttttacgg ttcctggcct tttgctggcc ttttgctcac     3120

atgttctttc ctgcgttatc ccctgattct gtggataacc gtattaccgc ctttgagtga     3180

gctgataccg ctcgccgcag ccgaacgacc gagcgcagcg agtcagtgag cgaggaagcg     3240

gaagagcgcc tgatgcggta ttttctcctt acgcatctgt gcggtatttc acaccgcata     3300

tggtgcactc tcagtacaat ctgctctgat gccgcatagt taagccagta tacactccgc     3360

tatcgctacg tgactgggtc atggctgcgc cccgacaccc gccaacaccc gctgacgcgc     3420

cctgacgggc ttgtctgctc ccggcatccg cttacagaca agctgtgacc gtctccggga     3480

gctgcatgtg tcagaggttt tcaccgtcat caccgaaacg cgcgaggcag ctgcggtaaa     3540

gctcatcagc gtggtcgtga agcgattcac agatgtctgc ctgttcatcc gcgtccagct     3600

cgttgagttt ctccagaagc gttaatgtct ggcttctgat aaagcgggcc atgttaaggg     3660

cggttttttc ctgtttggtc actgatgcct ccgtgtaagg gggatttctg ttcatggggg     3720

taatgatacc gatgaaacga gagaggatgc tcacgatacg ggttactgat gatgaacatg     3780

cccggttact ggaacgttgt gagggtaaac aactggcggt atggatgcgg cgggaccaga     3840

gaaaaatcac tcagggtcaa tgccagcgct tcgttaatac agatgtaggt gttccacagg     3900

gtagccagca gcatcctgcg atgcagatcc ggaacataat ggtgcagggc gctgacttcc     3960

gcgtttccag actttacgaa acacggaaac cgaagaccat tcatgttgtt gctcaggtcg     4020

cagacgtttt gcagcagcag tcgcttcacg ttcgctcgcg tatcggtgat tcattctgct     4080

aaccagtaag gcaaccccgc cagcctagcc gggtcctcaa cgacaggagc acgatcatgc     4140

gcacccgtgg ccaggaccca acgctgcccg ccgttaacgg ccaatacgca aaccgcctct     4200

ccccgcgcgt tggccgattc attaatgcag ctggcacgac aggtttcccg actggaaagc     4260

gggcagtgag cgcaacgcaa ttaatgtgag ttagctcact cattaggcac cccaggcttt     4320

acactttatg cttccggctc gtatgttgtg tggaattgtg agcggataac aatttcacac     4380

aggaaacagc tatgaca                                                    4397


<210>  181
<211>  4403
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  181
tgattacgaa ttcgagcggt taagaggtaa ttaaatggga aattctcttg caaaaaatgt       60

attattcggt ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga      120

tggtggagag ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct      180

gtcaggatat ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt      240

ggctgatatt gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta      300

taaagctgaa ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg      360

gtttgaaaaa gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag      420

tggccggata atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa      480

taaggcaagt tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa      540

tccattaatt aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga      600

ggaaagaact gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg      660

acggaactca ataaccctga ccacatcagc ataatatatt aatttaaatg atagcaatct      720

tactgggctg tgccacataa gattgctatt ttttttggag tcataatgga ttcttgtcat      780

aaaattgatt atgggttata cgccctggag attttagccc aataccataa cgtctctgtt      840

aacccggaag aaattaaaca tagatttgat acagacggga caggtctggg attaacgtca      900

tggttgcttg ctgcgaaatc tttagaacta aaggtaaaac aggtaaaaaa aacaattgat      960

cgatgataag ctgtcaaaca tgagaattac aacttatatc gtatggggct gacttcaggt     1020

gctacatttg aagagataaa ttgcactgaa atcctgcagg catgcaagct tggcactggc     1080

cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc     1140

agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     1200

ccaacagttg cgcagcctga atggcgaatg ccgttaacgg attcttgaag acgaaagggc     1260

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     1320

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     1380

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     1440

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     1500

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     1560

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     1620

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     1680

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     1740

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     1800

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     1860

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     1920

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     1980

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     2040

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     2100

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     2160

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     2220

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     2280

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     2340

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     2400

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     2460

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     2520

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     2580

tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag     2640

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     2700

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     2760

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     2820

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     2880

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     2940

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     3000

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     3060

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     3120

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt     3180

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag     3240

gaagcggaag agcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     3300

cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagtataca     3360

ctccgctatc gctacgtgac tgggtcatgg ctgcgccccg acacccgcca acacccgctg     3420

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     3480

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg aggcagctgc     3540

ggtaaagctc atcagcgtgg tcgtgaagcg attcacagat gtctgcctgt tcatccgcgt     3600

ccagctcgtt gagtttctcc agaagcgtta atgtctggct tctgataaag cgggccatgt     3660

taagggcggt tttttcctgt ttggtcactg atgcctccgt gtaaggggga tttctgttca     3720

tgggggtaat gataccgatg aaacgagaga ggatgctcac gatacgggtt actgatgatg     3780

aacatgcccg gttactggaa cgttgtgagg gtaaacaact ggcggtatgg atgcggcggg     3840

accagagaaa aatcactcag ggtcaatgcc agcgcttcgt taatacagat gtaggtgttc     3900

cacagggtag ccagcagcat cctgcgatgc agatccggaa cataatggtg cagggcgctg     3960

acttccgcgt ttccagactt tacgaaacac ggaaaccgaa gaccattcat gttgttgctc     4020

aggtcgcaga cgttttgcag cagcagtcgc ttcacgttcg ctcgcgtatc ggtgattcat     4080

tctgctaacc agtaaggcaa ccccgccagc ctagccgggt cctcaacgac aggagcacga     4140

tcatgcgcac ccgtggccag gacccaacgc tgcccgccgt taacggccaa tacgcaaacc     4200

gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg     4260

gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca     4320

ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt     4380

tcacacagga aacagctatg aca                                             4403


<210>  182
<211>  4409
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  182
tgattacgaa ttcgagctta actggttaag aggtaattaa atgggaaatt ctcttgcaaa       60

aaatgtatta ttcggtggaa aaggtaatga caagctgtac ggcagtgagg gggcagatct      120

gcttgatggt ggagaggggg atgatctcct gaaaggcgga tatggtaatg atatttatcg      180

ttatctgtca ggatatggtc atcatattat tgatgatgat ggggggaaag aggataaact      240

cagtttggct gatattgatt tccgggatgt ggccttcaag cgagaaggta atgacctcat      300

catgtataaa gctgaaggta atgttctttc cattggtcat aaaaatggta ttacattcag      360

gaactggttt gaaaaagagt caggtgatat ctctaatcac cagatagagc agatttttga      420

taaaagtggc cggataatca cacctgattc ccttaaaaag gcacttgagt atcaacagcg      480

taataataag gcaagttatg tgtatgggaa tgatgcatta gcctatggaa gtcagggtga      540

tcttaatcca ttaattaatg aaatcagcaa aatcatttca gctgcaggta gcttcgatgt      600

taaagaggaa agaactgcag cttctttatt gcagttgtcc ggtaatgcca gtgatttttc      660

atatggacgg aactcaataa ccctgaccac atcagcataa tatattaatt taaatgatag      720

caatcttact gggctgtgcc acataagatt gctatttttt ttggagtcat aatggattct      780

tgtcataaaa ttgattatgg gttatacgcc ctggagattt tagcccaata ccataacgtc      840

tctgttaacc cggaagaaat taaacataga tttgatacag acgggacagg tctgggatta      900

acgtcatggt tgcttgctgc gaaatcttta gaactaaagg taaaacaggt aaaaaaaaca      960

attgatcgat gataagctgt caaacatgag aattacaact tatatcgtat ggggctgact     1020

tcaggtgcta catttgaaga gataaattgc actgaaatcc tgcaggcatg caagcttggc     1080

actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg     1140

ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg     1200

cccttcccaa cagttgcgca gcctgaatgg cgaatgccgt taacggattc ttgaagacga     1260

aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag     1320

acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     1380

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     1440

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     1500

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     1560

gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt     1620

gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt     1680

ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat     1740

tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg     1800

acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta     1860

cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat     1920

catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag     1980

cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa     2040

ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca     2100

ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc     2160

ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt     2220

atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc     2280

gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat     2340

atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt     2400

tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac     2460

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc     2520

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca     2580

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta     2640

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct     2700

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg     2760

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc     2820

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta     2880

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg     2940

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt     3000

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg     3060

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg     3120

ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc     3180

gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg     3240

agcgaggaag cggaagagcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt     3300

tcacaccgca tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag     3360

tatacactcc gctatcgcta cgtgactggg tcatggctgc gccccgacac ccgccaacac     3420

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     3480

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc     3540

agctgcggta aagctcatca gcgtggtcgt gaagcgattc acagatgtct gcctgttcat     3600

ccgcgtccag ctcgttgagt ttctccagaa gcgttaatgt ctggcttctg ataaagcggg     3660

ccatgttaag ggcggttttt tcctgtttgg tcactgatgc ctccgtgtaa gggggatttc     3720

tgttcatggg ggtaatgata ccgatgaaac gagagaggat gctcacgata cgggttactg     3780

atgatgaaca tgcccggtta ctggaacgtt gtgagggtaa acaactggcg gtatggatgc     3840

ggcgggacca gagaaaaatc actcagggtc aatgccagcg cttcgttaat acagatgtag     3900

gtgttccaca gggtagccag cagcatcctg cgatgcagat ccggaacata atggtgcagg     3960

gcgctgactt ccgcgtttcc agactttacg aaacacggaa accgaagacc attcatgttg     4020

ttgctcaggt cgcagacgtt ttgcagcagc agtcgcttca cgttcgctcg cgtatcggtg     4080

attcattctg ctaaccagta aggcaacccc gccagcctag ccgggtcctc aacgacagga     4140

gcacgatcat gcgcacccgt ggccaggacc caacgctgcc cgccgttaac ggccaatacg     4200

caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc     4260

cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc     4320

accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata     4380

acaatttcac acaggaaaca gctatgaca                                       4409


<210>  183
<211>  4418
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  183
tgattacgaa ttcgagcaat ttttcattaa ctggttaaga ggtaattaaa tgggaaattc       60

tcttgcaaaa aatgtattat tcggtggaaa aggtaatgac aagctgtacg gcagtgaggg      120

ggcagatctg cttgatggtg gagaggggga tgatctcctg aaaggcggat atggtaatga      180

tatttatcgt tatctgtcag gatatggtca tcatattatt gatgatgatg gggggaaaga      240

ggataaactc agtttggctg atattgattt ccgggatgtg gccttcaagc gagaaggtaa      300

tgacctcatc atgtataaag ctgaaggtaa tgttctttcc attggtcata aaaatggtat      360

tacattcagg aactggtttg aaaaagagtc aggtgatatc tctaatcacc agatagagca      420

gatttttgat aaaagtggcc ggataatcac acctgattcc cttaaaaagg cacttgagta      480

tcaacagcgt aataataagg caagttatgt gtatgggaat gatgcattag cctatggaag      540

tcagggtgat cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtag      600

cttcgatgtt aaagaggaaa gaactgcagc ttctttattg cagttgtccg gtaatgccag      660

tgatttttca tatggacgga actcaataac cctgaccaca tcagcataat atattaattt      720

aaatgatagc aatcttactg ggctgtgcca cataagattg ctattttttt tggagtcata      780

atggattctt gtcataaaat tgattatggg ttatacgccc tggagatttt agcccaatac      840

cataacgtct ctgttaaccc ggaagaaatt aaacatagat ttgatacaga cgggacaggt      900

ctgggattaa cgtcatggtt gcttgctgcg aaatctttag aactaaaggt aaaacaggta      960

aaaaaaacaa ttgatcgatg ataagctgtc aaacatgaga attacaactt atatcgtatg     1020

gggctgactt caggtgctac atttgaagag ataaattgca ctgaaatcct gcaggcatgc     1080

aagcttggca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg gcgttaccca     1140

acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg aagaggcccg     1200

caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgccgtt aacggattct     1260

tgaagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat gataataatg     1320

gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc tatttgttta     1380

tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg ataaatgctt     1440

caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc ccttattccc     1500

ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt gaaagtaaaa     1560

gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct caacagcggt     1620

aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac ttttaaagtt     1680

ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact cggtcgccgc     1740

atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa gcatcttacg     1800

gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga taacactgcg     1860

gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt tttgcacaac     1920

atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga agccatacca     1980

aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg caaactatta     2040

actggcgaac tacttactct agcttcccgg caacaattaa tagactggat ggaggcggat     2100

aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat tgctgataaa     2160

tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc agatggtaag     2220

ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga tgaacgaaat     2280

agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc agaccaagtt     2340

tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag gatctaggtg     2400

aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc gttccactga     2460

gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt tctgcgcgta     2520

atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt gccggatcaa     2580

gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat accaaatact     2640

gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc accgcctaca     2700

tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa gtcgtgtctt     2760

accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg ctgaacgggg     2820

ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag atacctacag     2880

cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag gtatccggta     2940

agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa cgcctggtat     3000

ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt gtgatgctcg     3060

tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg gttcctggcc     3120

ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc tgtggataac     3180

cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac cgagcgcagc     3240

gagtcagtga gcgaggaagc ggaagagcgc ctgatgcggt attttctcct tacgcatctg     3300

tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga tgccgcatag     3360

ttaagccagt atacactccg ctatcgctac gtgactgggt catggctgcg ccccgacacc     3420

cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc gcttacagac     3480

aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca tcaccgaaac     3540

gcgcgaggca gctgcggtaa agctcatcag cgtggtcgtg aagcgattca cagatgtctg     3600

cctgttcatc cgcgtccagc tcgttgagtt tctccagaag cgttaatgtc tggcttctga     3660

taaagcgggc catgttaagg gcggtttttt cctgtttggt cactgatgcc tccgtgtaag     3720

ggggatttct gttcatgggg gtaatgatac cgatgaaacg agagaggatg ctcacgatac     3780

gggttactga tgatgaacat gcccggttac tggaacgttg tgagggtaaa caactggcgg     3840

tatggatgcg gcgggaccag agaaaaatca ctcagggtca atgccagcgc ttcgttaata     3900

cagatgtagg tgttccacag ggtagccagc agcatcctgc gatgcagatc cggaacataa     3960

tggtgcaggg cgctgacttc cgcgtttcca gactttacga aacacggaaa ccgaagacca     4020

ttcatgttgt tgctcaggtc gcagacgttt tgcagcagca gtcgcttcac gttcgctcgc     4080

gtatcggtga ttcattctgc taaccagtaa ggcaaccccg ccagcctagc cgggtcctca     4140

acgacaggag cacgatcatg cgcacccgtg gccaggaccc aacgctgccc gccgttaacg     4200

gccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca gctggcacga     4260

caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga gttagctcac     4320

tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt gtggaattgt     4380

gagcggataa caatttcaca caggaaacag ctatgaca                             4418


<210>  184
<211>  4427
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  184
tgattacgaa ttcgagctca gattttaatt tttcattaac tggttaagag gtaattaaat       60

gggaaattct cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg      120

cagtgagggg gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata      180

tggtaatgat atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg      240

ggggaaagag gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg      300

agaaggtaat gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa      360

aaatggtatt acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca      420

gatagagcag atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc      480

acttgagtat caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc      540

ctatggaagt cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc      600

tgcaggtagc ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg      660

taatgccagt gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataata      720

tattaattta aatgatagca atcttactgg gctgtgccac ataagattgc tatttttttt      780

ggagtcataa tggattcttg tcataaaatt gattatgggt tatacgccct ggagatttta      840

gcccaatacc ataacgtctc tgttaacccg gaagaaatta aacatagatt tgatacagac      900

gggacaggtc tgggattaac gtcatggttg cttgctgcga aatctttaga actaaaggta      960

aaacaggtaa aaaaaacaat tgatcgatga taagctgtca aacatgagaa ttacaactta     1020

tatcgtatgg ggctgacttc aggtgctaca tttgaagaga taaattgcac tgaaatcctg     1080

caggcatgca agcttggcac tggccgtcgt tttacaacgt cgtgactggg aaaaccctgg     1140

cgttacccaa cttaatcgcc ttgcagcaca tccccctttc gccagctggc gtaatagcga     1200

agaggcccgc accgatcgcc cttcccaaca gttgcgcagc ctgaatggcg aatgccgtta     1260

acggattctt gaagacgaaa gggcctcgtg atacgcctat ttttataggt taatgtcatg     1320

ataataatgg tttcttagac gtcaggtggc acttttcggg gaaatgtgcg cggaacccct     1380

atttgtttat ttttctaaat acattcaaat atgtatccgc tcatgagaca ataaccctga     1440

taaatgcttc aataatattg aaaaaggaag agtatgagta ttcaacattt ccgtgtcgcc     1500

cttattccct tttttgcggc attttgcctt cctgtttttg ctcacccaga aacgctggtg     1560

aaagtaaaag atgctgaaga tcagttgggt gcacgagtgg gttacatcga actggatctc     1620

aacagcggta agatccttga gagttttcgc cccgaagaac gttttccaat gatgagcact     1680

tttaaagttc tgctatgtgg cgcggtatta tcccgtattg acgccgggca agagcaactc     1740

ggtcgccgca tacactattc tcagaatgac ttggttgagt actcaccagt cacagaaaag     1800

catcttacgg atggcatgac agtaagagaa ttatgcagtg ctgccataac catgagtgat     1860

aacactgcgg ccaacttact tctgacaacg atcggaggac cgaaggagct aaccgctttt     1920

ttgcacaaca tgggggatca tgtaactcgc cttgatcgtt gggaaccgga gctgaatgaa     1980

gccataccaa acgacgagcg tgacaccacg atgcctgtag caatggcaac aacgttgcgc     2040

aaactattaa ctggcgaact acttactcta gcttcccggc aacaattaat agactggatg     2100

gaggcggata aagttgcagg accacttctg cgctcggccc ttccggctgg ctggtttatt     2160

gctgataaat ctggagccgg tgagcgtggg tctcgcggta tcattgcagc actggggcca     2220

gatggtaagc cctcccgtat cgtagttatc tacacgacgg ggagtcaggc aactatggat     2280

gaacgaaata gacagatcgc tgagataggt gcctcactga ttaagcattg gtaactgtca     2340

gaccaagttt actcatatat actttagatt gatttaaaac ttcattttta atttaaaagg     2400

atctaggtga agatcctttt tgataatctc atgaccaaaa tcccttaacg tgagttttcg     2460

ttccactgag cgtcagaccc cgtagaaaag atcaaaggat cttcttgaga tccttttttt     2520

ctgcgcgtaa tctgctgctt gcaaacaaaa aaaccaccgc taccagcggt ggtttgtttg     2580

ccggatcaag agctaccaac tctttttccg aaggtaactg gcttcagcag agcgcagata     2640

ccaaatactg tccttctagt gtagccgtag ttaggccacc acttcaagaa ctctgtagca     2700

ccgcctacat acctcgctct gctaatcctg ttaccagtgg ctgctgccag tggcgataag     2760

tcgtgtctta ccgggttgga ctcaagacga tagttaccgg ataaggcgca gcggtcgggc     2820

tgaacggggg gttcgtgcac acagcccagc ttggagcgaa cgacctacac cgaactgaga     2880

tacctacagc gtgagctatg agaaagcgcc acgcttcccg aagggagaaa ggcggacagg     2940

tatccggtaa gcggcagggt cggaacagga gagcgcacga gggagcttcc agggggaaac     3000

gcctggtatc tttatagtcc tgtcgggttt cgccacctct gacttgagcg tcgatttttg     3060

tgatgctcgt caggggggcg gagcctatgg aaaaacgcca gcaacgcggc ctttttacgg     3120

ttcctggcct tttgctggcc ttttgctcac atgttctttc ctgcgttatc ccctgattct     3180

gtggataacc gtattaccgc ctttgagtga gctgataccg ctcgccgcag ccgaacgacc     3240

gagcgcagcg agtcagtgag cgaggaagcg gaagagcgcc tgatgcggta ttttctcctt     3300

acgcatctgt gcggtatttc acaccgcata tggtgcactc tcagtacaat ctgctctgat     3360

gccgcatagt taagccagta tacactccgc tatcgctacg tgactgggtc atggctgcgc     3420

cccgacaccc gccaacaccc gctgacgcgc cctgacgggc ttgtctgctc ccggcatccg     3480

cttacagaca agctgtgacc gtctccggga gctgcatgtg tcagaggttt tcaccgtcat     3540

caccgaaacg cgcgaggcag ctgcggtaaa gctcatcagc gtggtcgtga agcgattcac     3600

agatgtctgc ctgttcatcc gcgtccagct cgttgagttt ctccagaagc gttaatgtct     3660

ggcttctgat aaagcgggcc atgttaaggg cggttttttc ctgtttggtc actgatgcct     3720

ccgtgtaagg gggatttctg ttcatggggg taatgatacc gatgaaacga gagaggatgc     3780

tcacgatacg ggttactgat gatgaacatg cccggttact ggaacgttgt gagggtaaac     3840

aactggcggt atggatgcgg cgggaccaga gaaaaatcac tcagggtcaa tgccagcgct     3900

tcgttaatac agatgtaggt gttccacagg gtagccagca gcatcctgcg atgcagatcc     3960

ggaacataat ggtgcagggc gctgacttcc gcgtttccag actttacgaa acacggaaac     4020

cgaagaccat tcatgttgtt gctcaggtcg cagacgtttt gcagcagcag tcgcttcacg     4080

ttcgctcgcg tatcggtgat tcattctgct aaccagtaag gcaaccccgc cagcctagcc     4140

gggtcctcaa cgacaggagc acgatcatgc gcacccgtgg ccaggaccca acgctgcccg     4200

ccgttaacgg ccaatacgca aaccgcctct ccccgcgcgt tggccgattc attaatgcag     4260

ctggcacgac aggtttcccg actggaaagc gggcagtgag cgcaacgcaa ttaatgtgag     4320

ttagctcact cattaggcac cccaggcttt acactttatg cttccggctc gtatgttgtg     4380

tggaattgtg agcggataac aatttcacac aggaaacagc tatgaca                   4427


<210>  185
<211>  4448
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  185
tgattacgaa ttcgagcata actgaagtaa aaagaaagtc agattttaat ttttcattaa       60

ctggttaaga ggtaattaaa tgggaaattc tcttgcaaaa aatgtattat tcggtggaaa      120

aggtaatgac aagctgtacg gcagtgaggg ggcagatctg cttgatggtg gagaggggga      180

tgatctcctg aaaggcggat atggtaatga tatttatcgt tatctgtcag gatatggtca      240

tcatattatt gatgatgatg gggggaaaga ggataaactc agtttggctg atattgattt      300

ccgggatgtg gccttcaagc gagaaggtaa tgacctcatc atgtataaag ctgaaggtaa      360

tgttctttcc attggtcata aaaatggtat tacattcagg aactggtttg aaaaagagtc      420

aggtgatatc tctaatcacc agatagagca gatttttgat aaaagtggcc ggataatcac      480

acctgattcc cttaaaaagg cacttgagta tcaacagcgt aataataagg caagttatgt      540

gtatgggaat gatgcattag cctatggaag tcagggtgat cttaatccat taattaatga      600

aatcagcaaa atcatttcag ctgcaggtag cttcgatgtt aaagaggaaa gaactgcagc      660

ttctttattg cagttgtccg gtaatgccag tgatttttca tatggacgga actcaataac      720

cctgaccaca tcagcataat atattaattt aaatgatagc aatcttactg ggctgtgcca      780

cataagattg ctattttttt tggagtcata atggattctt gtcataaaat tgattatggg      840

ttatacgccc tggagatttt agcccaatac cataacgtct ctgttaaccc ggaagaaatt      900

aaacatagat ttgatacaga cgggacaggt ctgggattaa cgtcatggtt gcttgctgcg      960

aaatctttag aactaaaggt aaaacaggta aaaaaaacaa ttgatcgatg ataagctgtc     1020

aaacatgaga attacaactt atatcgtatg gggctgactt caggtgctac atttgaagag     1080

ataaattgca ctgaaatcct gcaggcatgc aagcttggca ctggccgtcg ttttacaacg     1140

tcgtgactgg gaaaaccctg gcgttaccca acttaatcgc cttgcagcac atcccccttt     1200

cgccagctgg cgtaatagcg aagaggcccg caccgatcgc ccttcccaac agttgcgcag     1260

cctgaatggc gaatgccgtt aacggattct tgaagacgaa agggcctcgt gatacgccta     1320

tttttatagg ttaatgtcat gataataatg gtttcttaga cgtcaggtgg cacttttcgg     1380

ggaaatgtgc gcggaacccc tatttgttta tttttctaaa tacattcaaa tatgtatccg     1440

ctcatgagac aataaccctg ataaatgctt caataatatt gaaaaaggaa gagtatgagt     1500

attcaacatt tccgtgtcgc ccttattccc ttttttgcgg cattttgcct tcctgttttt     1560

gctcacccag aaacgctggt gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg     1620

ggttacatcg aactggatct caacagcggt aagatccttg agagttttcg ccccgaagaa     1680

cgttttccaa tgatgagcac ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt     1740

gacgccgggc aagagcaact cggtcgccgc atacactatt ctcagaatga cttggttgag     1800

tactcaccag tcacagaaaa gcatcttacg gatggcatga cagtaagaga attatgcagt     1860

gctgccataa ccatgagtga taacactgcg gccaacttac ttctgacaac gatcggagga     1920

ccgaaggagc taaccgcttt tttgcacaac atgggggatc atgtaactcg ccttgatcgt     1980

tgggaaccgg agctgaatga agccatacca aacgacgagc gtgacaccac gatgcctgta     2040

gcaatggcaa caacgttgcg caaactatta actggcgaac tacttactct agcttcccgg     2100

caacaattaa tagactggat ggaggcggat aaagttgcag gaccacttct gcgctcggcc     2160

cttccggctg gctggtttat tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt     2220

atcattgcag cactggggcc agatggtaag ccctcccgta tcgtagttat ctacacgacg     2280

gggagtcagg caactatgga tgaacgaaat agacagatcg ctgagatagg tgcctcactg     2340

attaagcatt ggtaactgtc agaccaagtt tactcatata tactttagat tgatttaaaa     2400

cttcattttt aatttaaaag gatctaggtg aagatccttt ttgataatct catgaccaaa     2460

atcccttaac gtgagttttc gttccactga gcgtcagacc ccgtagaaaa gatcaaagga     2520

tcttcttgag atcctttttt tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg     2580

ctaccagcgg tggtttgttt gccggatcaa gagctaccaa ctctttttcc gaaggtaact     2640

ggcttcagca gagcgcagat accaaatact gtccttctag tgtagccgta gttaggccac     2700

cacttcaaga actctgtagc accgcctaca tacctcgctc tgctaatcct gttaccagtg     2760

gctgctgcca gtggcgataa gtcgtgtctt accgggttgg actcaagacg atagttaccg     2820

gataaggcgc agcggtcggg ctgaacgggg ggttcgtgca cacagcccag cttggagcga     2880

acgacctaca ccgaactgag atacctacag cgtgagctat gagaaagcgc cacgcttccc     2940

gaagggagaa aggcggacag gtatccggta agcggcaggg tcggaacagg agagcgcacg     3000

agggagcttc cagggggaaa cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc     3060

tgacttgagc gtcgattttt gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc     3120

agcaacgcgg cctttttacg gttcctggcc ttttgctggc cttttgctca catgttcttt     3180

cctgcgttat cccctgattc tgtggataac cgtattaccg cctttgagtg agctgatacc     3240

gctcgccgca gccgaacgac cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc     3300

ctgatgcggt attttctcct tacgcatctg tgcggtattt cacaccgcat atggtgcact     3360

ctcagtacaa tctgctctga tgccgcatag ttaagccagt atacactccg ctatcgctac     3420

gtgactgggt catggctgcg ccccgacacc cgccaacacc cgctgacgcg ccctgacggg     3480

cttgtctgct cccggcatcc gcttacagac aagctgtgac cgtctccggg agctgcatgt     3540

gtcagaggtt ttcaccgtca tcaccgaaac gcgcgaggca gctgcggtaa agctcatcag     3600

cgtggtcgtg aagcgattca cagatgtctg cctgttcatc cgcgtccagc tcgttgagtt     3660

tctccagaag cgttaatgtc tggcttctga taaagcgggc catgttaagg gcggtttttt     3720

cctgtttggt cactgatgcc tccgtgtaag ggggatttct gttcatgggg gtaatgatac     3780

cgatgaaacg agagaggatg ctcacgatac gggttactga tgatgaacat gcccggttac     3840

tggaacgttg tgagggtaaa caactggcgg tatggatgcg gcgggaccag agaaaaatca     3900

ctcagggtca atgccagcgc ttcgttaata cagatgtagg tgttccacag ggtagccagc     3960

agcatcctgc gatgcagatc cggaacataa tggtgcaggg cgctgacttc cgcgtttcca     4020

gactttacga aacacggaaa ccgaagacca ttcatgttgt tgctcaggtc gcagacgttt     4080

tgcagcagca gtcgcttcac gttcgctcgc gtatcggtga ttcattctgc taaccagtaa     4140

ggcaaccccg ccagcctagc cgggtcctca acgacaggag cacgatcatg cgcacccgtg     4200

gccaggaccc aacgctgccc gccgttaacg gccaatacgc aaaccgcctc tccccgcgcg     4260

ttggccgatt cattaatgca gctggcacga caggtttccc gactggaaag cgggcagtga     4320

gcgcaacgca attaatgtga gttagctcac tcattaggca ccccaggctt tacactttat     4380

gcttccggct cgtatgttgt gtggaattgt gagcggataa caatttcaca caggaaacag     4440

ctatgaca                                                              4448


<210>  186
<211>  4469
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  186
tgattacgaa ttcgagcaaa caatatcacc acgagttaat aactgaagta aaaagaaagt       60

cagattttaa tttttcatta actggttaag aggtaattaa atgggaaatt ctcttgcaaa      120

aaatgtatta ttcggtggaa aaggtaatga caagctgtac ggcagtgagg gggcagatct      180

gcttgatggt ggagaggggg atgatctcct gaaaggcgga tatggtaatg atatttatcg      240

ttatctgtca ggatatggtc atcatattat tgatgatgat ggggggaaag aggataaact      300

cagtttggct gatattgatt tccgggatgt ggccttcaag cgagaaggta atgacctcat      360

catgtataaa gctgaaggta atgttctttc cattggtcat aaaaatggta ttacattcag      420

gaactggttt gaaaaagagt caggtgatat ctctaatcac cagatagagc agatttttga      480

taaaagtggc cggataatca cacctgattc ccttaaaaag gcacttgagt atcaacagcg      540

taataataag gcaagttatg tgtatgggaa tgatgcatta gcctatggaa gtcagggtga      600

tcttaatcca ttaattaatg aaatcagcaa aatcatttca gctgcaggta gcttcgatgt      660

taaagaggaa agaactgcag cttctttatt gcagttgtcc ggtaatgcca gtgatttttc      720

atatggacgg aactcaataa ccctgaccac atcagcataa tatattaatt taaatgatag      780

caatcttact gggctgtgcc acataagatt gctatttttt ttggagtcat aatggattct      840

tgtcataaaa ttgattatgg gttatacgcc ctggagattt tagcccaata ccataacgtc      900

tctgttaacc cggaagaaat taaacataga tttgatacag acgggacagg tctgggatta      960

acgtcatggt tgcttgctgc gaaatcttta gaactaaagg taaaacaggt aaaaaaaaca     1020

attgatcgat gataagctgt caaacatgag aattacaact tatatcgtat ggggctgact     1080

tcaggtgcta catttgaaga gataaattgc actgaaatcc tgcaggcatg caagcttggc     1140

actggccgtc gttttacaac gtcgtgactg ggaaaaccct ggcgttaccc aacttaatcg     1200

ccttgcagca catccccctt tcgccagctg gcgtaatagc gaagaggccc gcaccgatcg     1260

cccttcccaa cagttgcgca gcctgaatgg cgaatgccgt taacggattc ttgaagacga     1320

aagggcctcg tgatacgcct atttttatag gttaatgtca tgataataat ggtttcttag     1380

acgtcaggtg gcacttttcg gggaaatgtg cgcggaaccc ctatttgttt atttttctaa     1440

atacattcaa atatgtatcc gctcatgaga caataaccct gataaatgct tcaataatat     1500

tgaaaaagga agagtatgag tattcaacat ttccgtgtcg cccttattcc cttttttgcg     1560

gcattttgcc ttcctgtttt tgctcaccca gaaacgctgg tgaaagtaaa agatgctgaa     1620

gatcagttgg gtgcacgagt gggttacatc gaactggatc tcaacagcgg taagatcctt     1680

gagagttttc gccccgaaga acgttttcca atgatgagca cttttaaagt tctgctatgt     1740

ggcgcggtat tatcccgtat tgacgccggg caagagcaac tcggtcgccg catacactat     1800

tctcagaatg acttggttga gtactcacca gtcacagaaa agcatcttac ggatggcatg     1860

acagtaagag aattatgcag tgctgccata accatgagtg ataacactgc ggccaactta     1920

cttctgacaa cgatcggagg accgaaggag ctaaccgctt ttttgcacaa catgggggat     1980

catgtaactc gccttgatcg ttgggaaccg gagctgaatg aagccatacc aaacgacgag     2040

cgtgacacca cgatgcctgt agcaatggca acaacgttgc gcaaactatt aactggcgaa     2100

ctacttactc tagcttcccg gcaacaatta atagactgga tggaggcgga taaagttgca     2160

ggaccacttc tgcgctcggc ccttccggct ggctggttta ttgctgataa atctggagcc     2220

ggtgagcgtg ggtctcgcgg tatcattgca gcactggggc cagatggtaa gccctcccgt     2280

atcgtagtta tctacacgac ggggagtcag gcaactatgg atgaacgaaa tagacagatc     2340

gctgagatag gtgcctcact gattaagcat tggtaactgt cagaccaagt ttactcatat     2400

atactttaga ttgatttaaa acttcatttt taatttaaaa ggatctaggt gaagatcctt     2460

tttgataatc tcatgaccaa aatcccttaa cgtgagtttt cgttccactg agcgtcagac     2520

cccgtagaaa agatcaaagg atcttcttga gatccttttt ttctgcgcgt aatctgctgc     2580

ttgcaaacaa aaaaaccacc gctaccagcg gtggtttgtt tgccggatca agagctacca     2640

actctttttc cgaaggtaac tggcttcagc agagcgcaga taccaaatac tgtccttcta     2700

gtgtagccgt agttaggcca ccacttcaag aactctgtag caccgcctac atacctcgct     2760

ctgctaatcc tgttaccagt ggctgctgcc agtggcgata agtcgtgtct taccgggttg     2820

gactcaagac gatagttacc ggataaggcg cagcggtcgg gctgaacggg gggttcgtgc     2880

acacagccca gcttggagcg aacgacctac accgaactga gatacctaca gcgtgagcta     2940

tgagaaagcg ccacgcttcc cgaagggaga aaggcggaca ggtatccggt aagcggcagg     3000

gtcggaacag gagagcgcac gagggagctt ccagggggaa acgcctggta tctttatagt     3060

cctgtcgggt ttcgccacct ctgacttgag cgtcgatttt tgtgatgctc gtcagggggg     3120

cggagcctat ggaaaaacgc cagcaacgcg gcctttttac ggttcctggc cttttgctgg     3180

ccttttgctc acatgttctt tcctgcgtta tcccctgatt ctgtggataa ccgtattacc     3240

gcctttgagt gagctgatac cgctcgccgc agccgaacga ccgagcgcag cgagtcagtg     3300

agcgaggaag cggaagagcg cctgatgcgg tattttctcc ttacgcatct gtgcggtatt     3360

tcacaccgca tatggtgcac tctcagtaca atctgctctg atgccgcata gttaagccag     3420

tatacactcc gctatcgcta cgtgactggg tcatggctgc gccccgacac ccgccaacac     3480

ccgctgacgc gccctgacgg gcttgtctgc tcccggcatc cgcttacaga caagctgtga     3540

ccgtctccgg gagctgcatg tgtcagaggt tttcaccgtc atcaccgaaa cgcgcgaggc     3600

agctgcggta aagctcatca gcgtggtcgt gaagcgattc acagatgtct gcctgttcat     3660

ccgcgtccag ctcgttgagt ttctccagaa gcgttaatgt ctggcttctg ataaagcggg     3720

ccatgttaag ggcggttttt tcctgtttgg tcactgatgc ctccgtgtaa gggggatttc     3780

tgttcatggg ggtaatgata ccgatgaaac gagagaggat gctcacgata cgggttactg     3840

atgatgaaca tgcccggtta ctggaacgtt gtgagggtaa acaactggcg gtatggatgc     3900

ggcgggacca gagaaaaatc actcagggtc aatgccagcg cttcgttaat acagatgtag     3960

gtgttccaca gggtagccag cagcatcctg cgatgcagat ccggaacata atggtgcagg     4020

gcgctgactt ccgcgtttcc agactttacg aaacacggaa accgaagacc attcatgttg     4080

ttgctcaggt cgcagacgtt ttgcagcagc agtcgcttca cgttcgctcg cgtatcggtg     4140

attcattctg ctaaccagta aggcaacccc gccagcctag ccgggtcctc aacgacagga     4200

gcacgatcat gcgcacccgt ggccaggacc caacgctgcc cgccgttaac ggccaatacg     4260

caaaccgcct ctccccgcgc gttggccgat tcattaatgc agctggcacg acaggtttcc     4320

cgactggaaa gcgggcagtg agcgcaacgc aattaatgtg agttagctca ctcattaggc     4380

accccaggct ttacacttta tgcttccggc tcgtatgttg tgtggaattg tgagcggata     4440

acaatttcac acaggaaaca gctatgaca                                       4469


<210>  187
<211>  4490
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  187
tgattacgaa ttcgagccag ttagcgaata aaatttttaa acaatatcac cacgagttaa       60

taactgaagt aaaaagaaag tcagatttta atttttcatt aactggttaa gaggtaatta      120

aatgggaaat tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta      180

cggcagtgag ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg      240

atatggtaat gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga      300

tggggggaaa gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa      360

gcgagaaggt aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca      420

taaaaatggt attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca      480

ccagatagag cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa      540

ggcacttgag tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt      600

agcctatgga agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc      660

agctgcaggt agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc      720

cggtaatgcc agtgattttt catatggacg gaactcaata accctgacca catcagcata      780

atatattaat ttaaatgata gcaatcttac tgggctgtgc cacataagat tgctattttt      840

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt      900

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgataca      960

gacgggacag gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1020

gtaaaacagg taaaaaaaac aattgatcga tgataagctg tcaaacatga gaattacaac     1080

ttatatcgta tggggctgac ttcaggtgct acatttgaag agataaattg cactgaaatc     1140

ctgcaggcat gcaagcttgg cactggccgt cgttttacaa cgtcgtgact gggaaaaccc     1200

tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag     1260

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatgccg     1320

ttaacggatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     1380

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     1440

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     1500

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     1560

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     1620

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat     1680

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     1740

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa     1800

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa     1860

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     1920

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     1980

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     2040

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg     2100

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     2160

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     2220

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg     2280

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     2340

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     2400

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     2460

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     2520

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     2580

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     2640

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     2700

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     2760

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     2820

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     2880

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     2940

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     3000

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     3060

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     3120

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     3180

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     3240

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     3300

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg gtattttctc     3360

cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac aatctgctct     3420

gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg gtcatggctg     3480

cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     3540

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     3600

catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg tgaagcgatt     3660

cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga agcgttaatg     3720

tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg gtcactgatg     3780

cctccgtgta agggggattt ctgttcatgg gggtaatgat accgatgaaa cgagagagga     3840

tgctcacgat acgggttact gatgatgaac atgcccggtt actggaacgt tgtgagggta     3900

aacaactggc ggtatggatg cggcgggacc agagaaaaat cactcagggt caatgccagc     3960

gcttcgttaa tacagatgta ggtgttccac agggtagcca gcagcatcct gcgatgcaga     4020

tccggaacat aatggtgcag ggcgctgact tccgcgtttc cagactttac gaaacacgga     4080

aaccgaagac cattcatgtt gttgctcagg tcgcagacgt tttgcagcag cagtcgcttc     4140

acgttcgctc gcgtatcggt gattcattct gctaaccagt aaggcaaccc cgccagccta     4200

gccgggtcct caacgacagg agcacgatca tgcgcacccg tggccaggac ccaacgctgc     4260

ccgccgttaa cggccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     4320

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     4380

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt     4440

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgaca                4490


<210>  188
<211>  6801
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  188
tgattacgaa ttcgagcatg acaacaataa ccactgcaca aattaaaagc acactgcagt       60

ctgcaaagca atccgctgca aataaattgc actcagcagg acaaagcacg aaagatgcat      120

taaaaaaagc agcagagcaa acccgcaatg cgggaaacag actcatttta cttatcccta      180

aagattataa aggacagggt tcaagcctta atgaccttgt caggacggca gatgaactgg      240

gaattgaagt ccagtatgat gaaaagaatg gcacggcgat tactaaacag gtgttcggca      300

cagcagagaa actcattggc ctcaccgaac ggggagtgac tatctttgca ccacaattag      360

acaaattact gcaaaagtat caaaaagcag gtaatatatt aggtggcggt gctgaaaata      420

tcggtgataa cttaggaaag gcaggcggta tattgtcaac gtttcaaaat ttcctgggta      480

ctgcactttc ctcaatgaaa atagacgaac tgataaagaa acaaaaatct ggtggcaatg      540

tcagttcttc tgagatggca gaagcgagta ttgagctaat caatcaactt gtggatacag      600

ttgccagcct taataataat gttaactcat tttctcaaca actcaatact ctgggaagtg      660

tattatccaa tacaaagcac ctgaacggtg ttggtaataa gttacagaat ttacctaatc      720

ttgataatat cggtgcaggg ttagatactg tatcgggtat tttatctgcg atttcagcaa      780

gcttcattct gagcaatgca gatgcagata ccagaactaa agctgcagca ggtgttgaat      840

taacaacgaa agtactgggt aatgttggaa aaggtatttc tcaatatatt atcgcacagc      900

gcgctgcaca ggggttatct acatctgctg ctgctgccgg tttaattgct tctgctgtga      960

cactagcaat tagtcccctc tcattcctgt ccattgccga taagtttaaa cgtgccaata     1020

aaatagagga gtattcacaa cgattcaaaa aacttggata cgatggtgac agtttacttg     1080

ctgctttcca caaagaaaca ggggctattg atgcatcatt aacaacgata agcactgtac     1140

tggcttcagt atcttcaggt attagtgctg ctgcaacgac atctctggtt ggtgcaccgg     1200

taagcgcgct ggtaggcgct gttacgggga taatttcagg tatccttgag gcttcaaagc     1260

aggcaatgtt tgaacatgtt gccagtaaaa tggctgatgt tattgctgaa tgggagaaaa     1320

aacacggcaa aaattacttt gaaaatggat atgatgcccg ccatgctgca tttttagaag     1380

ataactttaa aatattatct cagtataata aagagtattc tgttgaaaga tcagtcctca     1440

ttacccagca acattgggat acgctgatag gtgagttagc tggtgtcacc agaaatggag     1500

acaaaacact cagtggtaaa agttatattg actattatga agaaggaaaa cgtctggaga     1560

aaaaaccgga tgaattccag aagcaagtct ttgacccatt gaaaggaaat attgaccttt     1620

ctgacagcaa atcttctacg ttattgaaat ttgttacgcc attattaact cccggtgagg     1680

aaattcgtga aaggaggcag tccggaaaat atgaatatat taccgagtta ttagtcaagg     1740

gtgttgataa atggacggtg aagggggttc aggacaaggg ggctgtatat gattactcta     1800

acctgattca gcatgcatca gtcggtaata accagtatcg ggaaatccgt attgagtcac     1860

acctgggaga cggggatgat aaggtctttt tatctgccgg ctcagccaat atctacgcag     1920

gtaaaggaca tgatgttgtt tattatgata aaacagacac tggttatctg accattgatg     1980

gcacaaaagc aaccgaagcg ggtaattaca cggtaacacg tgtacttggt ggcgatgtta     2040

aggttttaca ggaagttgtg aaggagcagg aggtttcagt cggaaaaaga actgaaaaaa     2100

cgcaatatcg gagttatgaa ttcactcata tcaatggtaa aaatttaaca gagactgata     2160

acttatattc cgtggaagaa cttattggga ccacgcgtgc cgacaagttt tttggcagta     2220

aatttactga tatcttccat ggcgcggatg gtgatgacct tatagaagga aatgatggga     2280

atgaccgctt atatggtgat aaaggtaatg acacactgag tggtggaaac ggagatgacc     2340

agctctatgg cggtgatggt aacgataagt tgattggggg agcaggtaat aattacctga     2400

acggcggaga tggagatgat gagcttcagg ttcagggaaa ttctcttgca aaaaatgtat     2460

tattcggtgg aaaaggtaat gacaagctgt acggcagtga gggggcagat ctgcttgatg     2520

gtggagaggg ggatgatctc ctgaaaggcg gatatggtaa tgatatttat cgttatctgt     2580

caggatatgg tcatcatatt attgatgatg atggggggaa agaggataaa ctcagtttgg     2640

ctgatattga tttccgggat gtggccttca agcgagaagg taatgacctc atcatgtata     2700

aagctgaagg taatgttctt tccattggtc ataaaaatgg tattacattc aggaactggt     2760

ttgaaaaaga gtcaggtgat atctctaatc accagataga gcagattttt gataaaagtg     2820

gccggataat cacacctgat tcccttaaaa aggcacttga gtatcaacag cgtaataata     2880

aggcaagtta tgtgtatggg aatgatgcat tagcctatgg aagtcagggt gatcttaatc     2940

cattaattaa tgaaatcagc aaaatcattt cagctgcagg tagcttcgat gttaaagagg     3000

aaagaactgc agcttcttta ttgcagttgt ccggtaatgc cagtgatttt tcatatggac     3060

ggaactcaat aaccctgacc acatcagcat aatatattaa tttaaatgat agcaatctta     3120

ctgggctgtg ccacataaga ttgctatttt ttttggagtc ataatggatt cttgtcataa     3180

aattgattat gggttatacg ccctggagat tttagcccaa taccataacg tctctgttaa     3240

cccggaagaa attaaacata gatttgatac agacgggaca ggtctgggat taacgtcatg     3300

gttgcttgct gcgaaatctt tagaactaaa ggtaaaacag gtaaaaaaaa caattgatcg     3360

atgataagct gtcaaacatg agaattacaa cttatatcgt atggggctga cttcaggtgc     3420

tacatttgaa gagataaatt gcactgaaat cctgcaggca tgcaagcttg gcactggccg     3480

tcgttttaca acgtcgtgac tgggaaaacc ctggcgttac ccaacttaat cgccttgcag     3540

cacatccccc tttcgccagc tggcgtaata gcgaagaggc ccgcaccgat cgcccttccc     3600

aacagttgcg cagcctgaat ggcgaatgcc gttaacggat tcttgaagac gaaagggcct     3660

cgtgatacgc ctatttttat aggttaatgt catgataata atggtttctt agacgtcagg     3720

tggcactttt cggggaaatg tgcgcggaac ccctatttgt ttatttttct aaatacattc     3780

aaatatgtat ccgctcatga gacaataacc ctgataaatg cttcaataat attgaaaaag     3840

gaagagtatg agtattcaac atttccgtgt cgcccttatt cccttttttg cggcattttg     3900

ccttcctgtt tttgctcacc cagaaacgct ggtgaaagta aaagatgctg aagatcagtt     3960

gggtgcacga gtgggttaca tcgaactgga tctcaacagc ggtaagatcc ttgagagttt     4020

tcgccccgaa gaacgttttc caatgatgag cacttttaaa gttctgctat gtggcgcggt     4080

attatcccgt attgacgccg ggcaagagca actcggtcgc cgcatacact attctcagaa     4140

tgacttggtt gagtactcac cagtcacaga aaagcatctt acggatggca tgacagtaag     4200

agaattatgc agtgctgcca taaccatgag tgataacact gcggccaact tacttctgac     4260

aacgatcgga ggaccgaagg agctaaccgc ttttttgcac aacatggggg atcatgtaac     4320

tcgccttgat cgttgggaac cggagctgaa tgaagccata ccaaacgacg agcgtgacac     4380

cacgatgcct gtagcaatgg caacaacgtt gcgcaaacta ttaactggcg aactacttac     4440

tctagcttcc cggcaacaat taatagactg gatggaggcg gataaagttg caggaccact     4500

tctgcgctcg gcccttccgg ctggctggtt tattgctgat aaatctggag ccggtgagcg     4560

tgggtctcgc ggtatcattg cagcactggg gccagatggt aagccctccc gtatcgtagt     4620

tatctacacg acggggagtc aggcaactat ggatgaacga aatagacaga tcgctgagat     4680

aggtgcctca ctgattaagc attggtaact gtcagaccaa gtttactcat atatacttta     4740

gattgattta aaacttcatt tttaatttaa aaggatctag gtgaagatcc tttttgataa     4800

tctcatgacc aaaatccctt aacgtgagtt ttcgttccac tgagcgtcag accccgtaga     4860

aaagatcaaa ggatcttctt gagatccttt ttttctgcgc gtaatctgct gcttgcaaac     4920

aaaaaaacca ccgctaccag cggtggtttg tttgccggat caagagctac caactctttt     4980

tccgaaggta actggcttca gcagagcgca gataccaaat actgtccttc tagtgtagcc     5040

gtagttaggc caccacttca agaactctgt agcaccgcct acatacctcg ctctgctaat     5100

cctgttacca gtggctgctg ccagtggcga taagtcgtgt cttaccgggt tggactcaag     5160

acgatagtta ccggataagg cgcagcggtc gggctgaacg gggggttcgt gcacacagcc     5220

cagcttggag cgaacgacct acaccgaact gagataccta cagcgtgagc tatgagaaag     5280

cgccacgctt cccgaaggga gaaaggcgga caggtatccg gtaagcggca gggtcggaac     5340

aggagagcgc acgagggagc ttccaggggg aaacgcctgg tatctttata gtcctgtcgg     5400

gtttcgccac ctctgacttg agcgtcgatt tttgtgatgc tcgtcagggg ggcggagcct     5460

atggaaaaac gccagcaacg cggccttttt acggttcctg gccttttgct ggccttttgc     5520

tcacatgttc tttcctgcgt tatcccctga ttctgtggat aaccgtatta ccgcctttga     5580

gtgagctgat accgctcgcc gcagccgaac gaccgagcgc agcgagtcag tgagcgagga     5640

agcggaagag cgcctgatgc ggtattttct ccttacgcat ctgtgcggta tttcacaccg     5700

catatggtgc actctcagta caatctgctc tgatgccgca tagttaagcc agtatacact     5760

ccgctatcgc tacgtgactg ggtcatggct gcgccccgac acccgccaac acccgctgac     5820

gcgccctgac gggcttgtct gctcccggca tccgcttaca gacaagctgt gaccgtctcc     5880

gggagctgca tgtgtcagag gttttcaccg tcatcaccga aacgcgcgag gcagctgcgg     5940

taaagctcat cagcgtggtc gtgaagcgat tcacagatgt ctgcctgttc atccgcgtcc     6000

agctcgttga gtttctccag aagcgttaat gtctggcttc tgataaagcg ggccatgtta     6060

agggcggttt tttcctgttt ggtcactgat gcctccgtgt aagggggatt tctgttcatg     6120

ggggtaatga taccgatgaa acgagagagg atgctcacga tacgggttac tgatgatgaa     6180

catgcccggt tactggaacg ttgtgagggt aaacaactgg cggtatggat gcggcgggac     6240

cagagaaaaa tcactcaggg tcaatgccag cgcttcgtta atacagatgt aggtgttcca     6300

cagggtagcc agcagcatcc tgcgatgcag atccggaaca taatggtgca gggcgctgac     6360

ttccgcgttt ccagacttta cgaaacacgg aaaccgaaga ccattcatgt tgttgctcag     6420

gtcgcagacg ttttgcagca gcagtcgctt cacgttcgct cgcgtatcgg tgattcattc     6480

tgctaaccag taaggcaacc ccgccagcct agccgggtcc tcaacgacag gagcacgatc     6540

atgcgcaccc gtggccagga cccaacgctg cccgccgtta acggccaata cgcaaaccgc     6600

ctctccccgc gcgttggccg attcattaat gcagctggca cgacaggttt cccgactgga     6660

aagcgggcag tgagcgcaac gcaattaatg tgagttagct cactcattag gcaccccagg     6720

ctttacactt tatgcttccg gctcgtatgt tgtgtggaat tgtgagcgga taacaatttc     6780

acacaggaaa cagctatgac a                                               6801


<210>  189
<211>  6812
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  189
tgattacgaa ttcgagcgag gtaattaaat gacaacaata accactgcac aaattaaaag       60

cacactgcag tctgcaaagc aatccgctgc aaataaattg cactcagcag gacaaagcac      120

gaaagatgca ttaaaaaaag cagcagagca aacccgcaat gcgggaaaca gactcatttt      180

acttatccct aaagattata aaggacaggg ttcaagcctt aatgaccttg tcaggacggc      240

agatgaactg ggaattgaag tccagtatga tgaaaagaat ggcacggcga ttactaaaca      300

ggtgttcggc acagcagaga aactcattgg cctcaccgaa cggggagtga ctatctttgc      360

accacaatta gacaaattac tgcaaaagta tcaaaaagca ggtaatatat taggtggcgg      420

tgctgaaaat atcggtgata acttaggaaa ggcaggcggt atattgtcaa cgtttcaaaa      480

tttcctgggt actgcacttt cctcaatgaa aatagacgaa ctgataaaga aacaaaaatc      540

tggtggcaat gtcagttctt ctgagatggc agaagcgagt attgagctaa tcaatcaact      600

tgtggataca gttgccagcc ttaataataa tgttaactca ttttctcaac aactcaatac      660

tctgggaagt gtattatcca atacaaagca cctgaacggt gttggtaata agttacagaa      720

tttacctaat cttgataata tcggtgcagg gttagatact gtatcgggta ttttatctgc      780

gatttcagca agcttcattc tgagcaatgc agatgcagat accagaacta aagctgcagc      840

aggtgttgaa ttaacaacga aagtactggg taatgttgga aaaggtattt ctcaatatat      900

tatcgcacag cgcgctgcac aggggttatc tacatctgct gctgctgccg gtttaattgc      960

ttctgctgtg acactagcaa ttagtcccct ctcattcctg tccattgccg ataagtttaa     1020

acgtgccaat aaaatagagg agtattcaca acgattcaaa aaacttggat acgatggtga     1080

cagtttactt gctgctttcc acaaagaaac aggggctatt gatgcatcat taacaacgat     1140

aagcactgta ctggcttcag tatcttcagg tattagtgct gctgcaacga catctctggt     1200

tggtgcaccg gtaagcgcgc tggtaggcgc tgttacgggg ataatttcag gtatccttga     1260

ggcttcaaag caggcaatgt ttgaacatgt tgccagtaaa atggctgatg ttattgctga     1320

atgggagaaa aaacacggca aaaattactt tgaaaatgga tatgatgccc gccatgctgc     1380

atttttagaa gataacttta aaatattatc tcagtataat aaagagtatt ctgttgaaag     1440

atcagtcctc attacccagc aacattggga tacgctgata ggtgagttag ctggtgtcac     1500

cagaaatgga gacaaaacac tcagtggtaa aagttatatt gactattatg aagaaggaaa     1560

acgtctggag aaaaaaccgg atgaattcca gaagcaagtc tttgacccat tgaaaggaaa     1620

tattgacctt tctgacagca aatcttctac gttattgaaa tttgttacgc cattattaac     1680

tcccggtgag gaaattcgtg aaaggaggca gtccggaaaa tatgaatata ttaccgagtt     1740

attagtcaag ggtgttgata aatggacggt gaagggggtt caggacaagg gggctgtata     1800

tgattactct aacctgattc agcatgcatc agtcggtaat aaccagtatc gggaaatccg     1860

tattgagtca cacctgggag acggggatga taaggtcttt ttatctgccg gctcagccaa     1920

tatctacgca ggtaaaggac atgatgttgt ttattatgat aaaacagaca ctggttatct     1980

gaccattgat ggcacaaaag caaccgaagc gggtaattac acggtaacac gtgtacttgg     2040

tggcgatgtt aaggttttac aggaagttgt gaaggagcag gaggtttcag tcggaaaaag     2100

aactgaaaaa acgcaatatc ggagttatga attcactcat atcaatggta aaaatttaac     2160

agagactgat aacttatatt ccgtggaaga acttattggg accacgcgtg ccgacaagtt     2220

ttttggcagt aaatttactg atatcttcca tggcgcggat ggtgatgacc ttatagaagg     2280

aaatgatggg aatgaccgct tatatggtga taaaggtaat gacacactga gtggtggaaa     2340

cggagatgac cagctctatg gcggtgatgg taacgataag ttgattgggg gagcaggtaa     2400

taattacctg aacggcggag atggagatga tgagcttcag gttcagggaa attctcttgc     2460

aaaaaatgta ttattcggtg gaaaaggtaa tgacaagctg tacggcagtg agggggcaga     2520

tctgcttgat ggtggagagg gggatgatct cctgaaaggc ggatatggta atgatattta     2580

tcgttatctg tcaggatatg gtcatcatat tattgatgat gatgggggga aagaggataa     2640

actcagtttg gctgatattg atttccggga tgtggccttc aagcgagaag gtaatgacct     2700

catcatgtat aaagctgaag gtaatgttct ttccattggt cataaaaatg gtattacatt     2760

caggaactgg tttgaaaaag agtcaggtga tatctctaat caccagatag agcagatttt     2820

tgataaaagt ggccggataa tcacacctga ttcccttaaa aaggcacttg agtatcaaca     2880

gcgtaataat aaggcaagtt atgtgtatgg gaatgatgca ttagcctatg gaagtcaggg     2940

tgatcttaat ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga     3000

tgttaaagag gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt     3060

ttcatatgga cggaactcaa taaccctgac cacatcagca taatatatta atttaaatga     3120

tagcaatctt actgggctgt gccacataag attgctattt tttttggagt cataatggat     3180

tcttgtcata aaattgatta tgggttatac gccctggaga ttttagccca ataccataac     3240

gtctctgtta acccggaaga aattaaacat agatttgata cagacgggac aggtctggga     3300

ttaacgtcat ggttgcttgc tgcgaaatct ttagaactaa aggtaaaaca ggtaaaaaaa     3360

acaattgatc gatgataagc tgtcaaacat gagaattaca acttatatcg tatggggctg     3420

acttcaggtg ctacatttga agagataaat tgcactgaaa tcctgcaggc atgcaagctt     3480

ggcactggcc gtcgttttac aacgtcgtga ctgggaaaac cctggcgtta cccaacttaa     3540

tcgccttgca gcacatcccc ctttcgccag ctggcgtaat agcgaagagg cccgcaccga     3600

tcgcccttcc caacagttgc gcagcctgaa tggcgaatgc cgttaacgga ttcttgaaga     3660

cgaaagggcc tcgtgatacg cctattttta taggttaatg tcatgataat aatggtttct     3720

tagacgtcag gtggcacttt tcggggaaat gtgcgcggaa cccctatttg tttatttttc     3780

taaatacatt caaatatgta tccgctcatg agacaataac cctgataaat gcttcaataa     3840

tattgaaaaa ggaagagtat gagtattcaa catttccgtg tcgcccttat tccctttttt     3900

gcggcatttt gccttcctgt ttttgctcac ccagaaacgc tggtgaaagt aaaagatgct     3960

gaagatcagt tgggtgcacg agtgggttac atcgaactgg atctcaacag cggtaagatc     4020

cttgagagtt ttcgccccga agaacgtttt ccaatgatga gcacttttaa agttctgcta     4080

tgtggcgcgg tattatcccg tattgacgcc gggcaagagc aactcggtcg ccgcatacac     4140

tattctcaga atgacttggt tgagtactca ccagtcacag aaaagcatct tacggatggc     4200

atgacagtaa gagaattatg cagtgctgcc ataaccatga gtgataacac tgcggccaac     4260

ttacttctga caacgatcgg aggaccgaag gagctaaccg cttttttgca caacatgggg     4320

gatcatgtaa ctcgccttga tcgttgggaa ccggagctga atgaagccat accaaacgac     4380

gagcgtgaca ccacgatgcc tgtagcaatg gcaacaacgt tgcgcaaact attaactggc     4440

gaactactta ctctagcttc ccggcaacaa ttaatagact ggatggaggc ggataaagtt     4500

gcaggaccac ttctgcgctc ggcccttccg gctggctggt ttattgctga taaatctgga     4560

gccggtgagc gtgggtctcg cggtatcatt gcagcactgg ggccagatgg taagccctcc     4620

cgtatcgtag ttatctacac gacggggagt caggcaacta tggatgaacg aaatagacag     4680

atcgctgaga taggtgcctc actgattaag cattggtaac tgtcagacca agtttactca     4740

tatatacttt agattgattt aaaacttcat ttttaattta aaaggatcta ggtgaagatc     4800

ctttttgata atctcatgac caaaatccct taacgtgagt tttcgttcca ctgagcgtca     4860

gaccccgtag aaaagatcaa aggatcttct tgagatcctt tttttctgcg cgtaatctgc     4920

tgcttgcaaa caaaaaaacc accgctacca gcggtggttt gtttgccgga tcaagagcta     4980

ccaactcttt ttccgaaggt aactggcttc agcagagcgc agataccaaa tactgtcctt     5040

ctagtgtagc cgtagttagg ccaccacttc aagaactctg tagcaccgcc tacatacctc     5100

gctctgctaa tcctgttacc agtggctgct gccagtggcg ataagtcgtg tcttaccggg     5160

ttggactcaa gacgatagtt accggataag gcgcagcggt cgggctgaac ggggggttcg     5220

tgcacacagc ccagcttgga gcgaacgacc tacaccgaac tgagatacct acagcgtgag     5280

ctatgagaaa gcgccacgct tcccgaaggg agaaaggcgg acaggtatcc ggtaagcggc     5340

agggtcggaa caggagagcg cacgagggag cttccagggg gaaacgcctg gtatctttat     5400

agtcctgtcg ggtttcgcca cctctgactt gagcgtcgat ttttgtgatg ctcgtcaggg     5460

gggcggagcc tatggaaaaa cgccagcaac gcggcctttt tacggttcct ggccttttgc     5520

tggccttttg ctcacatgtt ctttcctgcg ttatcccctg attctgtgga taaccgtatt     5580

accgcctttg agtgagctga taccgctcgc cgcagccgaa cgaccgagcg cagcgagtca     5640

gtgagcgagg aagcggaaga gcgcctgatg cggtattttc tccttacgca tctgtgcggt     5700

atttcacacc gcatatggtg cactctcagt acaatctgct ctgatgccgc atagttaagc     5760

cagtatacac tccgctatcg ctacgtgact gggtcatggc tgcgccccga cacccgccaa     5820

cacccgctga cgcgccctga cgggcttgtc tgctcccggc atccgcttac agacaagctg     5880

tgaccgtctc cgggagctgc atgtgtcaga ggttttcacc gtcatcaccg aaacgcgcga     5940

ggcagctgcg gtaaagctca tcagcgtggt cgtgaagcga ttcacagatg tctgcctgtt     6000

catccgcgtc cagctcgttg agtttctcca gaagcgttaa tgtctggctt ctgataaagc     6060

gggccatgtt aagggcggtt ttttcctgtt tggtcactga tgcctccgtg taagggggat     6120

ttctgttcat gggggtaatg ataccgatga aacgagagag gatgctcacg atacgggtta     6180

ctgatgatga acatgcccgg ttactggaac gttgtgaggg taaacaactg gcggtatgga     6240

tgcggcggga ccagagaaaa atcactcagg gtcaatgcca gcgcttcgtt aatacagatg     6300

taggtgttcc acagggtagc cagcagcatc ctgcgatgca gatccggaac ataatggtgc     6360

agggcgctga cttccgcgtt tccagacttt acgaaacacg gaaaccgaag accattcatg     6420

ttgttgctca ggtcgcagac gttttgcagc agcagtcgct tcacgttcgc tcgcgtatcg     6480

gtgattcatt ctgctaacca gtaaggcaac cccgccagcc tagccgggtc ctcaacgaca     6540

ggagcacgat catgcgcacc cgtggccagg acccaacgct gcccgccgtt aacggccaat     6600

acgcaaaccg cctctccccg cgcgttggcc gattcattaa tgcagctggc acgacaggtt     6660

tcccgactgg aaagcgggca gtgagcgcaa cgcaattaat gtgagttagc tcactcatta     6720

ggcaccccag gctttacact ttatgcttcc ggctcgtatg ttgtgtggaa ttgtgagcgg     6780

ataacaattt cacacaggaa acagctatga ca                                   6812


<210>  190
<211>  6842
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  190
tgattacgaa ttcgagctca gattttaatt tttcattaac tggttaagag gtaattaaat       60

gacaacaata accactgcac aaattaaaag cacactgcag tctgcaaagc aatccgctgc      120

aaataaattg cactcagcag gacaaagcac gaaagatgca ttaaaaaaag cagcagagca      180

aacccgcaat gcgggaaaca gactcatttt acttatccct aaagattata aaggacaggg      240

ttcaagcctt aatgaccttg tcaggacggc agatgaactg ggaattgaag tccagtatga      300

tgaaaagaat ggcacggcga ttactaaaca ggtgttcggc acagcagaga aactcattgg      360

cctcaccgaa cggggagtga ctatctttgc accacaatta gacaaattac tgcaaaagta      420

tcaaaaagca ggtaatatat taggtggcgg tgctgaaaat atcggtgata acttaggaaa      480

ggcaggcggt atattgtcaa cgtttcaaaa tttcctgggt actgcacttt cctcaatgaa      540

aatagacgaa ctgataaaga aacaaaaatc tggtggcaat gtcagttctt ctgagatggc      600

agaagcgagt attgagctaa tcaatcaact tgtggataca gttgccagcc ttaataataa      660

tgttaactca ttttctcaac aactcaatac tctgggaagt gtattatcca atacaaagca      720

cctgaacggt gttggtaata agttacagaa tttacctaat cttgataata tcggtgcagg      780

gttagatact gtatcgggta ttttatctgc gatttcagca agcttcattc tgagcaatgc      840

agatgcagat accagaacta aagctgcagc aggtgttgaa ttaacaacga aagtactggg      900

taatgttgga aaaggtattt ctcaatatat tatcgcacag cgcgctgcac aggggttatc      960

tacatctgct gctgctgccg gtttaattgc ttctgctgtg acactagcaa ttagtcccct     1020

ctcattcctg tccattgccg ataagtttaa acgtgccaat aaaatagagg agtattcaca     1080

acgattcaaa aaacttggat acgatggtga cagtttactt gctgctttcc acaaagaaac     1140

aggggctatt gatgcatcat taacaacgat aagcactgta ctggcttcag tatcttcagg     1200

tattagtgct gctgcaacga catctctggt tggtgcaccg gtaagcgcgc tggtaggcgc     1260

tgttacgggg ataatttcag gtatccttga ggcttcaaag caggcaatgt ttgaacatgt     1320

tgccagtaaa atggctgatg ttattgctga atgggagaaa aaacacggca aaaattactt     1380

tgaaaatgga tatgatgccc gccatgctgc atttttagaa gataacttta aaatattatc     1440

tcagtataat aaagagtatt ctgttgaaag atcagtcctc attacccagc aacattggga     1500

tacgctgata ggtgagttag ctggtgtcac cagaaatgga gacaaaacac tcagtggtaa     1560

aagttatatt gactattatg aagaaggaaa acgtctggag aaaaaaccgg atgaattcca     1620

gaagcaagtc tttgacccat tgaaaggaaa tattgacctt tctgacagca aatcttctac     1680

gttattgaaa tttgttacgc cattattaac tcccggtgag gaaattcgtg aaaggaggca     1740

gtccggaaaa tatgaatata ttaccgagtt attagtcaag ggtgttgata aatggacggt     1800

gaagggggtt caggacaagg gggctgtata tgattactct aacctgattc agcatgcatc     1860

agtcggtaat aaccagtatc gggaaatccg tattgagtca cacctgggag acggggatga     1920

taaggtcttt ttatctgccg gctcagccaa tatctacgca ggtaaaggac atgatgttgt     1980

ttattatgat aaaacagaca ctggttatct gaccattgat ggcacaaaag caaccgaagc     2040

gggtaattac acggtaacac gtgtacttgg tggcgatgtt aaggttttac aggaagttgt     2100

gaaggagcag gaggtttcag tcggaaaaag aactgaaaaa acgcaatatc ggagttatga     2160

attcactcat atcaatggta aaaatttaac agagactgat aacttatatt ccgtggaaga     2220

acttattggg accacgcgtg ccgacaagtt ttttggcagt aaatttactg atatcttcca     2280

tggcgcggat ggtgatgacc ttatagaagg aaatgatggg aatgaccgct tatatggtga     2340

taaaggtaat gacacactga gtggtggaaa cggagatgac cagctctatg gcggtgatgg     2400

taacgataag ttgattgggg gagcaggtaa taattacctg aacggcggag atggagatga     2460

tgagcttcag gttcagggaa attctcttgc aaaaaatgta ttattcggtg gaaaaggtaa     2520

tgacaagctg tacggcagtg agggggcaga tctgcttgat ggtggagagg gggatgatct     2580

cctgaaaggc ggatatggta atgatattta tcgttatctg tcaggatatg gtcatcatat     2640

tattgatgat gatgggggga aagaggataa actcagtttg gctgatattg atttccggga     2700

tgtggccttc aagcgagaag gtaatgacct catcatgtat aaagctgaag gtaatgttct     2760

ttccattggt cataaaaatg gtattacatt caggaactgg tttgaaaaag agtcaggtga     2820

tatctctaat caccagatag agcagatttt tgataaaagt ggccggataa tcacacctga     2880

ttcccttaaa aaggcacttg agtatcaaca gcgtaataat aaggcaagtt atgtgtatgg     2940

gaatgatgca ttagcctatg gaagtcaggg tgatcttaat ccattaatta atgaaatcag     3000

caaaatcatt tcagctgcag gtagcttcga tgttaaagag gaaagaactg cagcttcttt     3060

attgcagttg tccggtaatg ccagtgattt ttcatatgga cggaactcaa taaccctgac     3120

cacatcagca taatatatta atttaaatga tagcaatctt actgggctgt gccacataag     3180

attgctattt tttttggagt cataatggat tcttgtcata aaattgatta tgggttatac     3240

gccctggaga ttttagccca ataccataac gtctctgtta acccggaaga aattaaacat     3300

agatttgata cagacgggac aggtctggga ttaacgtcat ggttgcttgc tgcgaaatct     3360

ttagaactaa aggtaaaaca ggtaaaaaaa acaattgatc gatgataagc tgtcaaacat     3420

gagaattaca acttatatcg tatggggctg acttcaggtg ctacatttga agagataaat     3480

tgcactgaaa tcctgcaggc atgcaagctt ggcactggcc gtcgttttac aacgtcgtga     3540

ctgggaaaac cctggcgtta cccaacttaa tcgccttgca gcacatcccc ctttcgccag     3600

ctggcgtaat agcgaagagg cccgcaccga tcgcccttcc caacagttgc gcagcctgaa     3660

tggcgaatgc cgttaacgga ttcttgaaga cgaaagggcc tcgtgatacg cctattttta     3720

taggttaatg tcatgataat aatggtttct tagacgtcag gtggcacttt tcggggaaat     3780

gtgcgcggaa cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg     3840

agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa     3900

catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt ttttgctcac     3960

ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt tgggtgcacg agtgggttac     4020

atcgaactgg atctcaacag cggtaagatc cttgagagtt ttcgccccga agaacgtttt     4080

ccaatgatga gcacttttaa agttctgcta tgtggcgcgg tattatcccg tattgacgcc     4140

gggcaagagc aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca     4200

ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc     4260

ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg aggaccgaag     4320

gagctaaccg cttttttgca caacatgggg gatcatgtaa ctcgccttga tcgttgggaa     4380

ccggagctga atgaagccat accaaacgac gagcgtgaca ccacgatgcc tgtagcaatg     4440

gcaacaacgt tgcgcaaact attaactggc gaactactta ctctagcttc ccggcaacaa     4500

ttaatagact ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg     4560

gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt     4620

gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac gacggggagt     4680

caggcaacta tggatgaacg aaatagacag atcgctgaga taggtgcctc actgattaag     4740

cattggtaac tgtcagacca agtttactca tatatacttt agattgattt aaaacttcat     4800

ttttaattta aaaggatcta ggtgaagatc ctttttgata atctcatgac caaaatccct     4860

taacgtgagt tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct     4920

tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca     4980

gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt aactggcttc     5040

agcagagcgc agataccaaa tactgtcctt ctagtgtagc cgtagttagg ccaccacttc     5100

aagaactctg tagcaccgcc tacatacctc gctctgctaa tcctgttacc agtggctgct     5160

gccagtggcg ataagtcgtg tcttaccggg ttggactcaa gacgatagtt accggataag     5220

gcgcagcggt cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc     5280

tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg     5340

agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg cacgagggag     5400

cttccagggg gaaacgcctg gtatctttat agtcctgtcg ggtttcgcca cctctgactt     5460

gagcgtcgat ttttgtgatg ctcgtcaggg gggcggagcc tatggaaaaa cgccagcaac     5520

gcggcctttt tacggttcct ggccttttgc tggccttttg ctcacatgtt ctttcctgcg     5580

ttatcccctg attctgtgga taaccgtatt accgcctttg agtgagctga taccgctcgc     5640

cgcagccgaa cgaccgagcg cagcgagtca gtgagcgagg aagcggaaga gcgcctgatg     5700

cggtattttc tccttacgca tctgtgcggt atttcacacc gcatatggtg cactctcagt     5760

acaatctgct ctgatgccgc atagttaagc cagtatacac tccgctatcg ctacgtgact     5820

gggtcatggc tgcgccccga cacccgccaa cacccgctga cgcgccctga cgggcttgtc     5880

tgctcccggc atccgcttac agacaagctg tgaccgtctc cgggagctgc atgtgtcaga     5940

ggttttcacc gtcatcaccg aaacgcgcga ggcagctgcg gtaaagctca tcagcgtggt     6000

cgtgaagcga ttcacagatg tctgcctgtt catccgcgtc cagctcgttg agtttctcca     6060

gaagcgttaa tgtctggctt ctgataaagc gggccatgtt aagggcggtt ttttcctgtt     6120

tggtcactga tgcctccgtg taagggggat ttctgttcat gggggtaatg ataccgatga     6180

aacgagagag gatgctcacg atacgggtta ctgatgatga acatgcccgg ttactggaac     6240

gttgtgaggg taaacaactg gcggtatgga tgcggcggga ccagagaaaa atcactcagg     6300

gtcaatgcca gcgcttcgtt aatacagatg taggtgttcc acagggtagc cagcagcatc     6360

ctgcgatgca gatccggaac ataatggtgc agggcgctga cttccgcgtt tccagacttt     6420

acgaaacacg gaaaccgaag accattcatg ttgttgctca ggtcgcagac gttttgcagc     6480

agcagtcgct tcacgttcgc tcgcgtatcg gtgattcatt ctgctaacca gtaaggcaac     6540

cccgccagcc tagccgggtc ctcaacgaca ggagcacgat catgcgcacc cgtggccagg     6600

acccaacgct gcccgccgtt aacggccaat acgcaaaccg cctctccccg cgcgttggcc     6660

gattcattaa tgcagctggc acgacaggtt tcccgactgg aaagcgggca gtgagcgcaa     6720

cgcaattaat gtgagttagc tcactcatta ggcaccccag gctttacact ttatgcttcc     6780

ggctcgtatg ttgtgtggaa ttgtgagcgg ataacaattt cacacaggaa acagctatga     6840

ca                                                                    6842


<210>  191
<211>  6863
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  191
tgattacgaa ttcgagcata actgaagtaa aaagaaagtc agattttaat ttttcattaa       60

ctggttaaga ggtaattaaa tgacaacaat aaccactgca caaattaaaa gcacactgca      120

gtctgcaaag caatccgctg caaataaatt gcactcagca ggacaaagca cgaaagatgc      180

attaaaaaaa gcagcagagc aaacccgcaa tgcgggaaac agactcattt tacttatccc      240

taaagattat aaaggacagg gttcaagcct taatgacctt gtcaggacgg cagatgaact      300

gggaattgaa gtccagtatg atgaaaagaa tggcacggcg attactaaac aggtgttcgg      360

cacagcagag aaactcattg gcctcaccga acggggagtg actatctttg caccacaatt      420

agacaaatta ctgcaaaagt atcaaaaagc aggtaatata ttaggtggcg gtgctgaaaa      480

tatcggtgat aacttaggaa aggcaggcgg tatattgtca acgtttcaaa atttcctggg      540

tactgcactt tcctcaatga aaatagacga actgataaag aaacaaaaat ctggtggcaa      600

tgtcagttct tctgagatgg cagaagcgag tattgagcta atcaatcaac ttgtggatac      660

agttgccagc cttaataata atgttaactc attttctcaa caactcaata ctctgggaag      720

tgtattatcc aatacaaagc acctgaacgg tgttggtaat aagttacaga atttacctaa      780

tcttgataat atcggtgcag ggttagatac tgtatcgggt attttatctg cgatttcagc      840

aagcttcatt ctgagcaatg cagatgcaga taccagaact aaagctgcag caggtgttga      900

attaacaacg aaagtactgg gtaatgttgg aaaaggtatt tctcaatata ttatcgcaca      960

gcgcgctgca caggggttat ctacatctgc tgctgctgcc ggtttaattg cttctgctgt     1020

gacactagca attagtcccc tctcattcct gtccattgcc gataagttta aacgtgccaa     1080

taaaatagag gagtattcac aacgattcaa aaaacttgga tacgatggtg acagtttact     1140

tgctgctttc cacaaagaaa caggggctat tgatgcatca ttaacaacga taagcactgt     1200

actggcttca gtatcttcag gtattagtgc tgctgcaacg acatctctgg ttggtgcacc     1260

ggtaagcgcg ctggtaggcg ctgttacggg gataatttca ggtatccttg aggcttcaaa     1320

gcaggcaatg tttgaacatg ttgccagtaa aatggctgat gttattgctg aatgggagaa     1380

aaaacacggc aaaaattact ttgaaaatgg atatgatgcc cgccatgctg catttttaga     1440

agataacttt aaaatattat ctcagtataa taaagagtat tctgttgaaa gatcagtcct     1500

cattacccag caacattggg atacgctgat aggtgagtta gctggtgtca ccagaaatgg     1560

agacaaaaca ctcagtggta aaagttatat tgactattat gaagaaggaa aacgtctgga     1620

gaaaaaaccg gatgaattcc agaagcaagt ctttgaccca ttgaaaggaa atattgacct     1680

ttctgacagc aaatcttcta cgttattgaa atttgttacg ccattattaa ctcccggtga     1740

ggaaattcgt gaaaggaggc agtccggaaa atatgaatat attaccgagt tattagtcaa     1800

gggtgttgat aaatggacgg tgaagggggt tcaggacaag ggggctgtat atgattactc     1860

taacctgatt cagcatgcat cagtcggtaa taaccagtat cgggaaatcc gtattgagtc     1920

acacctggga gacggggatg ataaggtctt tttatctgcc ggctcagcca atatctacgc     1980

aggtaaagga catgatgttg tttattatga taaaacagac actggttatc tgaccattga     2040

tggcacaaaa gcaaccgaag cgggtaatta cacggtaaca cgtgtacttg gtggcgatgt     2100

taaggtttta caggaagttg tgaaggagca ggaggtttca gtcggaaaaa gaactgaaaa     2160

aacgcaatat cggagttatg aattcactca tatcaatggt aaaaatttaa cagagactga     2220

taacttatat tccgtggaag aacttattgg gaccacgcgt gccgacaagt tttttggcag     2280

taaatttact gatatcttcc atggcgcgga tggtgatgac cttatagaag gaaatgatgg     2340

gaatgaccgc ttatatggtg ataaaggtaa tgacacactg agtggtggaa acggagatga     2400

ccagctctat ggcggtgatg gtaacgataa gttgattggg ggagcaggta ataattacct     2460

gaacggcgga gatggagatg atgagcttca ggttcaggga aattctcttg caaaaaatgt     2520

attattcggt ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga     2580

tggtggagag ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct     2640

gtcaggatat ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt     2700

ggctgatatt gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta     2760

taaagctgaa ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg     2820

gtttgaaaaa gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag     2880

tggccggata atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa     2940

taaggcaagt tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa     3000

tccattaatt aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga     3060

ggaaagaact gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg     3120

acggaactca ataaccctga ccacatcagc ataatatatt aatttaaatg atagcaatct     3180

tactgggctg tgccacataa gattgctatt ttttttggag tcataatgga ttcttgtcat     3240

aaaattgatt atgggttata cgccctggag attttagccc aataccataa cgtctctgtt     3300

aacccggaag aaattaaaca tagatttgat acagacggga caggtctggg attaacgtca     3360

tggttgcttg ctgcgaaatc tttagaacta aaggtaaaac aggtaaaaaa aacaattgat     3420

cgatgataag ctgtcaaaca tgagaattac aacttatatc gtatggggct gacttcaggt     3480

gctacatttg aagagataaa ttgcactgaa atcctgcagg catgcaagct tggcactggc     3540

cgtcgtttta caacgtcgtg actgggaaaa ccctggcgtt acccaactta atcgccttgc     3600

agcacatccc cctttcgcca gctggcgtaa tagcgaagag gcccgcaccg atcgcccttc     3660

ccaacagttg cgcagcctga atggcgaatg ccgttaacgg attcttgaag acgaaagggc     3720

ctcgtgatac gcctattttt ataggttaat gtcatgataa taatggtttc ttagacgtca     3780

ggtggcactt ttcggggaaa tgtgcgcgga acccctattt gtttattttt ctaaatacat     3840

tcaaatatgt atccgctcat gagacaataa ccctgataaa tgcttcaata atattgaaaa     3900

aggaagagta tgagtattca acatttccgt gtcgccctta ttcccttttt tgcggcattt     3960

tgccttcctg tttttgctca cccagaaacg ctggtgaaag taaaagatgc tgaagatcag     4020

ttgggtgcac gagtgggtta catcgaactg gatctcaaca gcggtaagat ccttgagagt     4080

tttcgccccg aagaacgttt tccaatgatg agcactttta aagttctgct atgtggcgcg     4140

gtattatccc gtattgacgc cgggcaagag caactcggtc gccgcataca ctattctcag     4200

aatgacttgg ttgagtactc accagtcaca gaaaagcatc ttacggatgg catgacagta     4260

agagaattat gcagtgctgc cataaccatg agtgataaca ctgcggccaa cttacttctg     4320

acaacgatcg gaggaccgaa ggagctaacc gcttttttgc acaacatggg ggatcatgta     4380

actcgccttg atcgttggga accggagctg aatgaagcca taccaaacga cgagcgtgac     4440

accacgatgc ctgtagcaat ggcaacaacg ttgcgcaaac tattaactgg cgaactactt     4500

actctagctt cccggcaaca attaatagac tggatggagg cggataaagt tgcaggacca     4560

cttctgcgct cggcccttcc ggctggctgg tttattgctg ataaatctgg agccggtgag     4620

cgtgggtctc gcggtatcat tgcagcactg gggccagatg gtaagccctc ccgtatcgta     4680

gttatctaca cgacggggag tcaggcaact atggatgaac gaaatagaca gatcgctgag     4740

ataggtgcct cactgattaa gcattggtaa ctgtcagacc aagtttactc atatatactt     4800

tagattgatt taaaacttca tttttaattt aaaaggatct aggtgaagat cctttttgat     4860

aatctcatga ccaaaatccc ttaacgtgag ttttcgttcc actgagcgtc agaccccgta     4920

gaaaagatca aaggatcttc ttgagatcct ttttttctgc gcgtaatctg ctgcttgcaa     4980

acaaaaaaac caccgctacc agcggtggtt tgtttgccgg atcaagagct accaactctt     5040

tttccgaagg taactggctt cagcagagcg cagataccaa atactgtcct tctagtgtag     5100

ccgtagttag gccaccactt caagaactct gtagcaccgc ctacatacct cgctctgcta     5160

atcctgttac cagtggctgc tgccagtggc gataagtcgt gtcttaccgg gttggactca     5220

agacgatagt taccggataa ggcgcagcgg tcgggctgaa cggggggttc gtgcacacag     5280

cccagcttgg agcgaacgac ctacaccgaa ctgagatacc tacagcgtga gctatgagaa     5340

agcgccacgc ttcccgaagg gagaaaggcg gacaggtatc cggtaagcgg cagggtcgga     5400

acaggagagc gcacgaggga gcttccaggg ggaaacgcct ggtatcttta tagtcctgtc     5460

gggtttcgcc acctctgact tgagcgtcga tttttgtgat gctcgtcagg ggggcggagc     5520

ctatggaaaa acgccagcaa cgcggccttt ttacggttcc tggccttttg ctggcctttt     5580

gctcacatgt tctttcctgc gttatcccct gattctgtgg ataaccgtat taccgccttt     5640

gagtgagctg ataccgctcg ccgcagccga acgaccgagc gcagcgagtc agtgagcgag     5700

gaagcggaag agcgcctgat gcggtatttt ctccttacgc atctgtgcgg tatttcacac     5760

cgcatatggt gcactctcag tacaatctgc tctgatgccg catagttaag ccagtataca     5820

ctccgctatc gctacgtgac tgggtcatgg ctgcgccccg acacccgcca acacccgctg     5880

acgcgccctg acgggcttgt ctgctcccgg catccgctta cagacaagct gtgaccgtct     5940

ccgggagctg catgtgtcag aggttttcac cgtcatcacc gaaacgcgcg aggcagctgc     6000

ggtaaagctc atcagcgtgg tcgtgaagcg attcacagat gtctgcctgt tcatccgcgt     6060

ccagctcgtt gagtttctcc agaagcgtta atgtctggct tctgataaag cgggccatgt     6120

taagggcggt tttttcctgt ttggtcactg atgcctccgt gtaaggggga tttctgttca     6180

tgggggtaat gataccgatg aaacgagaga ggatgctcac gatacgggtt actgatgatg     6240

aacatgcccg gttactggaa cgttgtgagg gtaaacaact ggcggtatgg atgcggcggg     6300

accagagaaa aatcactcag ggtcaatgcc agcgcttcgt taatacagat gtaggtgttc     6360

cacagggtag ccagcagcat cctgcgatgc agatccggaa cataatggtg cagggcgctg     6420

acttccgcgt ttccagactt tacgaaacac ggaaaccgaa gaccattcat gttgttgctc     6480

aggtcgcaga cgttttgcag cagcagtcgc ttcacgttcg ctcgcgtatc ggtgattcat     6540

tctgctaacc agtaaggcaa ccccgccagc ctagccgggt cctcaacgac aggagcacga     6600

tcatgcgcac ccgtggccag gacccaacgc tgcccgccgt taacggccaa tacgcaaacc     6660

gcctctcccc gcgcgttggc cgattcatta atgcagctgg cacgacaggt ttcccgactg     6720

gaaagcgggc agtgagcgca acgcaattaa tgtgagttag ctcactcatt aggcacccca     6780

ggctttacac tttatgcttc cggctcgtat gttgtgtgga attgtgagcg gataacaatt     6840

tcacacagga aacagctatg aca                                             6863


<210>  192
<211>  6884
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  192
tgattacgaa ttcgagcaaa caatatcacc acgagttaat aactgaagta aaaagaaagt       60

cagattttaa tttttcatta actggttaag aggtaattaa atgacaacaa taaccactgc      120

acaaattaaa agcacactgc agtctgcaaa gcaatccgct gcaaataaat tgcactcagc      180

aggacaaagc acgaaagatg cattaaaaaa agcagcagag caaacccgca atgcgggaaa      240

cagactcatt ttacttatcc ctaaagatta taaaggacag ggttcaagcc ttaatgacct      300

tgtcaggacg gcagatgaac tgggaattga agtccagtat gatgaaaaga atggcacggc      360

gattactaaa caggtgttcg gcacagcaga gaaactcatt ggcctcaccg aacggggagt      420

gactatcttt gcaccacaat tagacaaatt actgcaaaag tatcaaaaag caggtaatat      480

attaggtggc ggtgctgaaa atatcggtga taacttagga aaggcaggcg gtatattgtc      540

aacgtttcaa aatttcctgg gtactgcact ttcctcaatg aaaatagacg aactgataaa      600

gaaacaaaaa tctggtggca atgtcagttc ttctgagatg gcagaagcga gtattgagct      660

aatcaatcaa cttgtggata cagttgccag ccttaataat aatgttaact cattttctca      720

acaactcaat actctgggaa gtgtattatc caatacaaag cacctgaacg gtgttggtaa      780

taagttacag aatttaccta atcttgataa tatcggtgca gggttagata ctgtatcggg      840

tattttatct gcgatttcag caagcttcat tctgagcaat gcagatgcag ataccagaac      900

taaagctgca gcaggtgttg aattaacaac gaaagtactg ggtaatgttg gaaaaggtat      960

ttctcaatat attatcgcac agcgcgctgc acaggggtta tctacatctg ctgctgctgc     1020

cggtttaatt gcttctgctg tgacactagc aattagtccc ctctcattcc tgtccattgc     1080

cgataagttt aaacgtgcca ataaaataga ggagtattca caacgattca aaaaacttgg     1140

atacgatggt gacagtttac ttgctgcttt ccacaaagaa acaggggcta ttgatgcatc     1200

attaacaacg ataagcactg tactggcttc agtatcttca ggtattagtg ctgctgcaac     1260

gacatctctg gttggtgcac cggtaagcgc gctggtaggc gctgttacgg ggataatttc     1320

aggtatcctt gaggcttcaa agcaggcaat gtttgaacat gttgccagta aaatggctga     1380

tgttattgct gaatgggaga aaaaacacgg caaaaattac tttgaaaatg gatatgatgc     1440

ccgccatgct gcatttttag aagataactt taaaatatta tctcagtata ataaagagta     1500

ttctgttgaa agatcagtcc tcattaccca gcaacattgg gatacgctga taggtgagtt     1560

agctggtgtc accagaaatg gagacaaaac actcagtggt aaaagttata ttgactatta     1620

tgaagaagga aaacgtctgg agaaaaaacc ggatgaattc cagaagcaag tctttgaccc     1680

attgaaagga aatattgacc tttctgacag caaatcttct acgttattga aatttgttac     1740

gccattatta actcccggtg aggaaattcg tgaaaggagg cagtccggaa aatatgaata     1800

tattaccgag ttattagtca agggtgttga taaatggacg gtgaaggggg ttcaggacaa     1860

gggggctgta tatgattact ctaacctgat tcagcatgca tcagtcggta ataaccagta     1920

tcgggaaatc cgtattgagt cacacctggg agacggggat gataaggtct ttttatctgc     1980

cggctcagcc aatatctacg caggtaaagg acatgatgtt gtttattatg ataaaacaga     2040

cactggttat ctgaccattg atggcacaaa agcaaccgaa gcgggtaatt acacggtaac     2100

acgtgtactt ggtggcgatg ttaaggtttt acaggaagtt gtgaaggagc aggaggtttc     2160

agtcggaaaa agaactgaaa aaacgcaata tcggagttat gaattcactc atatcaatgg     2220

taaaaattta acagagactg ataacttata ttccgtggaa gaacttattg ggaccacgcg     2280

tgccgacaag ttttttggca gtaaatttac tgatatcttc catggcgcgg atggtgatga     2340

ccttatagaa ggaaatgatg ggaatgaccg cttatatggt gataaaggta atgacacact     2400

gagtggtgga aacggagatg accagctcta tggcggtgat ggtaacgata agttgattgg     2460

gggagcaggt aataattacc tgaacggcgg agatggagat gatgagcttc aggttcaggg     2520

aaattctctt gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag     2580

tgagggggca gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg     2640

taatgatatt tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg     2700

gaaagaggat aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga     2760

aggtaatgac ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa     2820

tggtattaca ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat     2880

agagcagatt tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact     2940

tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta     3000

tggaagtcag ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc     3060

aggtagcttc gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa     3120

tgccagtgat ttttcatatg gacggaactc aataaccctg accacatcag cataatatat     3180

taatttaaat gatagcaatc ttactgggct gtgccacata agattgctat tttttttgga     3240

gtcataatgg attcttgtca taaaattgat tatgggttat acgccctgga gattttagcc     3300

caataccata acgtctctgt taacccggaa gaaattaaac atagatttga tacagacggg     3360

acaggtctgg gattaacgtc atggttgctt gctgcgaaat ctttagaact aaaggtaaaa     3420

caggtaaaaa aaacaattga tcgatgataa gctgtcaaac atgagaatta caacttatat     3480

cgtatggggc tgacttcagg tgctacattt gaagagataa attgcactga aatcctgcag     3540

gcatgcaagc ttggcactgg ccgtcgtttt acaacgtcgt gactgggaaa accctggcgt     3600

tacccaactt aatcgccttg cagcacatcc ccctttcgcc agctggcgta atagcgaaga     3660

ggcccgcacc gatcgccctt cccaacagtt gcgcagcctg aatggcgaat gccgttaacg     3720

gattcttgaa gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata     3780

ataatggttt cttagacgtc aggtggcact tttcggggaa atgtgcgcgg aacccctatt     3840

tgtttatttt tctaaataca ttcaaatatg tatccgctca tgagacaata accctgataa     3900

atgcttcaat aatattgaaa aaggaagagt atgagtattc aacatttccg tgtcgccctt     3960

attccctttt ttgcggcatt ttgccttcct gtttttgctc acccagaaac gctggtgaaa     4020

gtaaaagatg ctgaagatca gttgggtgca cgagtgggtt acatcgaact ggatctcaac     4080

agcggtaaga tccttgagag ttttcgcccc gaagaacgtt ttccaatgat gagcactttt     4140

aaagttctgc tatgtggcgc ggtattatcc cgtattgacg ccgggcaaga gcaactcggt     4200

cgccgcatac actattctca gaatgacttg gttgagtact caccagtcac agaaaagcat     4260

cttacggatg gcatgacagt aagagaatta tgcagtgctg ccataaccat gagtgataac     4320

actgcggcca acttacttct gacaacgatc ggaggaccga aggagctaac cgcttttttg     4380

cacaacatgg gggatcatgt aactcgcctt gatcgttggg aaccggagct gaatgaagcc     4440

ataccaaacg acgagcgtga caccacgatg cctgtagcaa tggcaacaac gttgcgcaaa     4500

ctattaactg gcgaactact tactctagct tcccggcaac aattaataga ctggatggag     4560

gcggataaag ttgcaggacc acttctgcgc tcggcccttc cggctggctg gtttattgct     4620

gataaatctg gagccggtga gcgtgggtct cgcggtatca ttgcagcact ggggccagat     4680

ggtaagccct cccgtatcgt agttatctac acgacgggga gtcaggcaac tatggatgaa     4740

cgaaatagac agatcgctga gataggtgcc tcactgatta agcattggta actgtcagac     4800

caagtttact catatatact ttagattgat ttaaaacttc atttttaatt taaaaggatc     4860

taggtgaaga tcctttttga taatctcatg accaaaatcc cttaacgtga gttttcgttc     4920

cactgagcgt cagaccccgt agaaaagatc aaaggatctt cttgagatcc tttttttctg     4980

cgcgtaatct gctgcttgca aacaaaaaaa ccaccgctac cagcggtggt ttgtttgccg     5040

gatcaagagc taccaactct ttttccgaag gtaactggct tcagcagagc gcagatacca     5100

aatactgtcc ttctagtgta gccgtagtta ggccaccact tcaagaactc tgtagcaccg     5160

cctacatacc tcgctctgct aatcctgtta ccagtggctg ctgccagtgg cgataagtcg     5220

tgtcttaccg ggttggactc aagacgatag ttaccggata aggcgcagcg gtcgggctga     5280

acggggggtt cgtgcacaca gcccagcttg gagcgaacga cctacaccga actgagatac     5340

ctacagcgtg agctatgaga aagcgccacg cttcccgaag ggagaaaggc ggacaggtat     5400

ccggtaagcg gcagggtcgg aacaggagag cgcacgaggg agcttccagg gggaaacgcc     5460

tggtatcttt atagtcctgt cgggtttcgc cacctctgac ttgagcgtcg atttttgtga     5520

tgctcgtcag gggggcggag cctatggaaa aacgccagca acgcggcctt tttacggttc     5580

ctggcctttt gctggccttt tgctcacatg ttctttcctg cgttatcccc tgattctgtg     5640

gataaccgta ttaccgcctt tgagtgagct gataccgctc gccgcagccg aacgaccgag     5700

cgcagcgagt cagtgagcga ggaagcggaa gagcgcctga tgcggtattt tctccttacg     5760

catctgtgcg gtatttcaca ccgcatatgg tgcactctca gtacaatctg ctctgatgcc     5820

gcatagttaa gccagtatac actccgctat cgctacgtga ctgggtcatg gctgcgcccc     5880

gacacccgcc aacacccgct gacgcgccct gacgggcttg tctgctcccg gcatccgctt     5940

acagacaagc tgtgaccgtc tccgggagct gcatgtgtca gaggttttca ccgtcatcac     6000

cgaaacgcgc gaggcagctg cggtaaagct catcagcgtg gtcgtgaagc gattcacaga     6060

tgtctgcctg ttcatccgcg tccagctcgt tgagtttctc cagaagcgtt aatgtctggc     6120

ttctgataaa gcgggccatg ttaagggcgg ttttttcctg tttggtcact gatgcctccg     6180

tgtaaggggg atttctgttc atgggggtaa tgataccgat gaaacgagag aggatgctca     6240

cgatacgggt tactgatgat gaacatgccc ggttactgga acgttgtgag ggtaaacaac     6300

tggcggtatg gatgcggcgg gaccagagaa aaatcactca gggtcaatgc cagcgcttcg     6360

ttaatacaga tgtaggtgtt ccacagggta gccagcagca tcctgcgatg cagatccgga     6420

acataatggt gcagggcgct gacttccgcg tttccagact ttacgaaaca cggaaaccga     6480

agaccattca tgttgttgct caggtcgcag acgttttgca gcagcagtcg cttcacgttc     6540

gctcgcgtat cggtgattca ttctgctaac cagtaaggca accccgccag cctagccggg     6600

tcctcaacga caggagcacg atcatgcgca cccgtggcca ggacccaacg ctgcccgccg     6660

ttaacggcca atacgcaaac cgcctctccc cgcgcgttgg ccgattcatt aatgcagctg     6720

gcacgacagg tttcccgact ggaaagcggg cagtgagcgc aacgcaatta atgtgagtta     6780

gctcactcat taggcacccc aggctttaca ctttatgctt ccggctcgta tgttgtgtgg     6840

aattgtgagc ggataacaat ttcacacagg aaacagctat gaca                      6884


<210>  193
<211>  6905
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  193
tgattacgaa ttcgagccag ttagcgaata aaatttttaa acaatatcac cacgagttaa       60

taactgaagt aaaaagaaag tcagatttta atttttcatt aactggttaa gaggtaatta      120

aatgacaaca ataaccactg cacaaattaa aagcacactg cagtctgcaa agcaatccgc      180

tgcaaataaa ttgcactcag caggacaaag cacgaaagat gcattaaaaa aagcagcaga      240

gcaaacccgc aatgcgggaa acagactcat tttacttatc cctaaagatt ataaaggaca      300

gggttcaagc cttaatgacc ttgtcaggac ggcagatgaa ctgggaattg aagtccagta      360

tgatgaaaag aatggcacgg cgattactaa acaggtgttc ggcacagcag agaaactcat      420

tggcctcacc gaacggggag tgactatctt tgcaccacaa ttagacaaat tactgcaaaa      480

gtatcaaaaa gcaggtaata tattaggtgg cggtgctgaa aatatcggtg ataacttagg      540

aaaggcaggc ggtatattgt caacgtttca aaatttcctg ggtactgcac tttcctcaat      600

gaaaatagac gaactgataa agaaacaaaa atctggtggc aatgtcagtt cttctgagat      660

ggcagaagcg agtattgagc taatcaatca acttgtggat acagttgcca gccttaataa      720

taatgttaac tcattttctc aacaactcaa tactctggga agtgtattat ccaatacaaa      780

gcacctgaac ggtgttggta ataagttaca gaatttacct aatcttgata atatcggtgc      840

agggttagat actgtatcgg gtattttatc tgcgatttca gcaagcttca ttctgagcaa      900

tgcagatgca gataccagaa ctaaagctgc agcaggtgtt gaattaacaa cgaaagtact      960

gggtaatgtt ggaaaaggta tttctcaata tattatcgca cagcgcgctg cacaggggtt     1020

atctacatct gctgctgctg ccggtttaat tgcttctgct gtgacactag caattagtcc     1080

cctctcattc ctgtccattg ccgataagtt taaacgtgcc aataaaatag aggagtattc     1140

acaacgattc aaaaaacttg gatacgatgg tgacagttta cttgctgctt tccacaaaga     1200

aacaggggct attgatgcat cattaacaac gataagcact gtactggctt cagtatcttc     1260

aggtattagt gctgctgcaa cgacatctct ggttggtgca ccggtaagcg cgctggtagg     1320

cgctgttacg gggataattt caggtatcct tgaggcttca aagcaggcaa tgtttgaaca     1380

tgttgccagt aaaatggctg atgttattgc tgaatgggag aaaaaacacg gcaaaaatta     1440

ctttgaaaat ggatatgatg cccgccatgc tgcattttta gaagataact ttaaaatatt     1500

atctcagtat aataaagagt attctgttga aagatcagtc ctcattaccc agcaacattg     1560

ggatacgctg ataggtgagt tagctggtgt caccagaaat ggagacaaaa cactcagtgg     1620

taaaagttat attgactatt atgaagaagg aaaacgtctg gagaaaaaac cggatgaatt     1680

ccagaagcaa gtctttgacc cattgaaagg aaatattgac ctttctgaca gcaaatcttc     1740

tacgttattg aaatttgtta cgccattatt aactcccggt gaggaaattc gtgaaaggag     1800

gcagtccgga aaatatgaat atattaccga gttattagtc aagggtgttg ataaatggac     1860

ggtgaagggg gttcaggaca agggggctgt atatgattac tctaacctga ttcagcatgc     1920

atcagtcggt aataaccagt atcgggaaat ccgtattgag tcacacctgg gagacgggga     1980

tgataaggtc tttttatctg ccggctcagc caatatctac gcaggtaaag gacatgatgt     2040

tgtttattat gataaaacag acactggtta tctgaccatt gatggcacaa aagcaaccga     2100

agcgggtaat tacacggtaa cacgtgtact tggtggcgat gttaaggttt tacaggaagt     2160

tgtgaaggag caggaggttt cagtcggaaa aagaactgaa aaaacgcaat atcggagtta     2220

tgaattcact catatcaatg gtaaaaattt aacagagact gataacttat attccgtgga     2280

agaacttatt gggaccacgc gtgccgacaa gttttttggc agtaaattta ctgatatctt     2340

ccatggcgcg gatggtgatg accttataga aggaaatgat gggaatgacc gcttatatgg     2400

tgataaaggt aatgacacac tgagtggtgg aaacggagat gaccagctct atggcggtga     2460

tggtaacgat aagttgattg ggggagcagg taataattac ctgaacggcg gagatggaga     2520

tgatgagctt caggttcagg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg     2580

taatgacaag ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga     2640

tctcctgaaa ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca     2700

tattattgat gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg     2760

ggatgtggcc ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt     2820

tctttccatt ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg     2880

tgatatctct aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc     2940

tgattccctt aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta     3000

tgggaatgat gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat     3060

cagcaaaatc atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc     3120

tttattgcag ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct     3180

gaccacatca gcataatata ttaatttaaa tgatagcaat cttactgggc tgtgccacat     3240

aagattgcta ttttttttgg agtcataatg gattcttgtc ataaaattga ttatgggtta     3300

tacgccctgg agattttagc ccaataccat aacgtctctg ttaacccgga agaaattaaa     3360

catagatttg atacagacgg gacaggtctg ggattaacgt catggttgct tgctgcgaaa     3420

tctttagaac taaaggtaaa acaggtaaaa aaaacaattg atcgatgata agctgtcaaa     3480

catgagaatt acaacttata tcgtatgggg ctgacttcag gtgctacatt tgaagagata     3540

aattgcactg aaatcctgca ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg     3600

tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc cccctttcgc     3660

cagctggcgt aatagcgaag aggcccgcac cgatcgccct tcccaacagt tgcgcagcct     3720

gaatggcgaa tgccgttaac ggattcttga agacgaaagg gcctcgtgat acgcctattt     3780

ttataggtta atgtcatgat aataatggtt tcttagacgt caggtggcac ttttcgggga     3840

aatgtgcgcg gaacccctat ttgtttattt ttctaaatac attcaaatat gtatccgctc     3900

atgagacaat aaccctgata aatgcttcaa taatattgaa aaaggaagag tatgagtatt     3960

caacatttcc gtgtcgccct tattcccttt tttgcggcat tttgccttcc tgtttttgct     4020

cacccagaaa cgctggtgaa agtaaaagat gctgaagatc agttgggtgc acgagtgggt     4080

tacatcgaac tggatctcaa cagcggtaag atccttgaga gttttcgccc cgaagaacgt     4140

tttccaatga tgagcacttt taaagttctg ctatgtggcg cggtattatc ccgtattgac     4200

gccgggcaag agcaactcgg tcgccgcata cactattctc agaatgactt ggttgagtac     4260

tcaccagtca cagaaaagca tcttacggat ggcatgacag taagagaatt atgcagtgct     4320

gccataacca tgagtgataa cactgcggcc aacttacttc tgacaacgat cggaggaccg     4380

aaggagctaa ccgctttttt gcacaacatg ggggatcatg taactcgcct tgatcgttgg     4440

gaaccggagc tgaatgaagc cataccaaac gacgagcgtg acaccacgat gcctgtagca     4500

atggcaacaa cgttgcgcaa actattaact ggcgaactac ttactctagc ttcccggcaa     4560

caattaatag actggatgga ggcggataaa gttgcaggac cacttctgcg ctcggccctt     4620

ccggctggct ggtttattgc tgataaatct ggagccggtg agcgtgggtc tcgcggtatc     4680

attgcagcac tggggccaga tggtaagccc tcccgtatcg tagttatcta cacgacgggg     4740

agtcaggcaa ctatggatga acgaaataga cagatcgctg agataggtgc ctcactgatt     4800

aagcattggt aactgtcaga ccaagtttac tcatatatac tttagattga tttaaaactt     4860

catttttaat ttaaaaggat ctaggtgaag atcctttttg ataatctcat gaccaaaatc     4920

ccttaacgtg agttttcgtt ccactgagcg tcagaccccg tagaaaagat caaaggatct     4980

tcttgagatc ctttttttct gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta     5040

ccagcggtgg tttgtttgcc ggatcaagag ctaccaactc tttttccgaa ggtaactggc     5100

ttcagcagag cgcagatacc aaatactgtc cttctagtgt agccgtagtt aggccaccac     5160

ttcaagaact ctgtagcacc gcctacatac ctcgctctgc taatcctgtt accagtggct     5220

gctgccagtg gcgataagtc gtgtcttacc gggttggact caagacgata gttaccggat     5280

aaggcgcagc ggtcgggctg aacggggggt tcgtgcacac agcccagctt ggagcgaacg     5340

acctacaccg aactgagata cctacagcgt gagctatgag aaagcgccac gcttcccgaa     5400

gggagaaagg cggacaggta tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg     5460

gagcttccag ggggaaacgc ctggtatctt tatagtcctg tcgggtttcg ccacctctga     5520

cttgagcgtc gatttttgtg atgctcgtca ggggggcgga gcctatggaa aaacgccagc     5580

aacgcggcct ttttacggtt cctggccttt tgctggcctt ttgctcacat gttctttcct     5640

gcgttatccc ctgattctgt ggataaccgt attaccgcct ttgagtgagc tgataccgct     5700

cgccgcagcc gaacgaccga gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg     5760

atgcggtatt ttctccttac gcatctgtgc ggtatttcac accgcatatg gtgcactctc     5820

agtacaatct gctctgatgc cgcatagtta agccagtata cactccgcta tcgctacgtg     5880

actgggtcat ggctgcgccc cgacacccgc caacacccgc tgacgcgccc tgacgggctt     5940

gtctgctccc ggcatccgct tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc     6000

agaggttttc accgtcatca ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt     6060

ggtcgtgaag cgattcacag atgtctgcct gttcatccgc gtccagctcg ttgagtttct     6120

ccagaagcgt taatgtctgg cttctgataa agcgggccat gttaagggcg gttttttcct     6180

gtttggtcac tgatgcctcc gtgtaagggg gatttctgtt catgggggta atgataccga     6240

tgaaacgaga gaggatgctc acgatacggg ttactgatga tgaacatgcc cggttactgg     6300

aacgttgtga gggtaaacaa ctggcggtat ggatgcggcg ggaccagaga aaaatcactc     6360

agggtcaatg ccagcgcttc gttaatacag atgtaggtgt tccacagggt agccagcagc     6420

atcctgcgat gcagatccgg aacataatgg tgcagggcgc tgacttccgc gtttccagac     6480

tttacgaaac acggaaaccg aagaccattc atgttgttgc tcaggtcgca gacgttttgc     6540

agcagcagtc gcttcacgtt cgctcgcgta tcggtgattc attctgctaa ccagtaaggc     6600

aaccccgcca gcctagccgg gtcctcaacg acaggagcac gatcatgcgc acccgtggcc     6660

aggacccaac gctgcccgcc gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg     6720

gccgattcat taatgcagct ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg     6780

caacgcaatt aatgtgagtt agctcactca ttaggcaccc caggctttac actttatgct     6840

tccggctcgt atgttgtgtg gaattgtgag cggataacaa tttcacacag gaaacagcta     6900

tgaca                                                                 6905


<210>  194
<211>  6777
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  194
tgattacgaa ttcgagctcc caaaactcat gttggtaaag tatcagaatt tcatggaggt       60

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      120

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatga      180

caacaataac cactgcacaa attaaaagca cactgcagtc tgcaaagcaa tccgctgcaa      240

ataaattgca ctcagcagga caaagcacga aagatgcatt aaaaaaagca gcagagcaaa      300

cccgcaatgc gggaaacaga ctcattttac ttatccctaa agattataaa ggacagggtt      360

caagccttaa tgaccttgtc aggacggcag atgaactggg aattgaagtc cagtatgatg      420

aaaagaatgg cacggcgatt actaaacagg tgttcggcac agcagagaaa ctcattggcc      480

tcaccgaacg gggagtgact atctttgcac cacaattaga caaattactg caaaagtatc      540

aaaaagcagg taatatatta ggtggcggtg ctgaaaatat cggtgataac ttaggaaagg      600

caggcggtat attgtcaacg tttcaaaatt tcctgggtac tgcactttcc tcaatgaaaa      660

tagacgaact gataaagaaa caaaaatctg gtggcaatgt cagttcttct gagatggcag      720

aagcgagtat tgagctaatc aatcaacttg tggatacagt tgccagcctt aataataatg      780

ttaactcatt ttctcaacaa ctcaatactc tgggaagtgt attatccaat acaaagcacc      840

tgaacggtgt tggtaataag ttacagaatt tacctaatct tgataatatc ggtgcagggt      900

tagatactgt atcgggtatt ttatctgcga tttcagcaag cttcattctg agcaatgcag      960

atgcagatac cagaactaaa gctgcagcag gtgttgaatt aacaacgaaa gtactgggta     1020

atgttggaaa aggtatttct caatatatta tcgcacagcg cgctgcacag gggttatcta     1080

catctgctgc tgctgccggt ttaattgctt ctgctgtgac actagcaatt agtcccctct     1140

cattcctgtc cattgccgat aagtttaaac gtgccaataa aatagaggag tattcacaac     1200

gattcaaaaa acttggatac gatggtgaca gtttacttgc tgctttccac aaagaaacag     1260

gggctattga tgcatcatta acaacgataa gcactgtact ggcttcagta tcttcaggta     1320

ttagtgctgc tgcaacgaca tctctggttg gtgcaccggt aagcgcgctg gtaggcgctg     1380

ttacggggat aatttcaggt atccttgagg cttcaaagca ggcaatgttt gaacatgttg     1440

ccagtaaaat ggctgatgtt attgctgaat gggagaaaaa acacggcaaa aattactttg     1500

aaaatggata tgatgcccgc catgctgcat ttttagaaga taactttaaa atattatctc     1560

agtataataa agagtattct gttgaaagat cagtcctcat tacccagcaa cattgggata     1620

cgctgatagg tgagttagct ggtgtcacca gaaatggaga caaaacactc agtggtaaaa     1680

gttatattga ctattatgaa gaaggaaaac gtctggagaa aaaaccggat gaattccaga     1740

agcaagtctt tgacccattg aaaggaaata ttgacctttc tgacagcaaa tcttctacgt     1800

tattgaaatt tgttacgcca ttattaactc ccggtgagga aattcgtgaa aggaggcagt     1860

ccggaaaata tgaatatatt accgagttat tagtcaaggg tgttgataaa tggacggtga     1920

agggggttca ggacaagggg gctgtatatg attactctaa cctgattcag catgcatcag     1980

tcggtaataa ccagtatcgg gaaatccgta ttgagtcaca cctgggagac ggggatgata     2040

aggtcttttt atctgccggc tcagccaata tctacgcagg taaaggacat gatgttgttt     2100

attatgataa aacagacact ggttatctga ccattgatgg cacaaaagca accgaagcgg     2160

gtaattacac ggtaacacgt gtacttggtg gcgatgttaa ggttttacag gaagttgtga     2220

aggagcagga ggtttcagtc ggaaaaagaa ctgaaaaaac gcaatatcgg agttatgaat     2280

tcactcatat caatggtaaa aatttaacag agactgataa cttatattcc gtggaagaac     2340

ttattgggac cacgcgtgcc gacaagtttt ttggcagtaa atttactgat atcttccatg     2400

gcgcggatgg tgatgacctt atagaaggaa atgatgggaa tgaccgctta tatggtgata     2460

aaggtaatga cacactgagt ggtggaaacg gagatgacca gctctatggc ggtgatggta     2520

acgataagtt gattggggga gcaggtaata attacctgaa cggcggagat ggagatgatg     2580

agcttcaggt tcagggaaat tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg     2640

acaagctgta cggcagtgag ggggcagatc tgcttgatgg tggagagggg gatgatctcc     2700

tgaaaggcgg atatggtaat gatatttatc gttatctgtc aggatatggt catcatatta     2760

ttgatgatga tggggggaaa gaggataaac tcagtttggc tgatattgat ttccgggatg     2820

tggccttcaa gcgagaaggt aatgacctca tcatgtataa agctgaaggt aatgttcttt     2880

ccattggtca taaaaatggt attacattca ggaactggtt tgaaaaagag tcaggtgata     2940

tctctaatca ccagatagag cagatttttg ataaaagtgg ccggataatc acacctgatt     3000

cccttaaaaa ggcacttgag tatcaacagc gtaataataa ggcaagttat gtgtatggga     3060

atgatgcatt agcctatgga agtcagggtg atcttaatcc attaattaat gaaatcagca     3120

aaatcatttc agctgcaggt agcttcgatg ttaaagagga aagaactgca gcttctttat     3180

tgcagttgtc cggtaatgcc agtgattttt catatggacg gaactcaata accctgacca     3240

catcagcata atatattaat ttaaatgata gcaatcttac tgggctgtgc cacataagat     3300

tgctattttt tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc     3360

cctggagatt ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag     3420

atttgataca gacgggacag gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt     3480

agaactaaag gtaaaacagg taaaaaaaac aattgatcga tgataagctg tcaaacatga     3540

gaattacaac ttatatcgta tggggctgac ttcaggtgct acatttgaag agataaattg     3600

cactgaaatc ctgcaggcat gcaagcttgg cactggccgt cgttttacaa cgtcgtgact     3660

gggaaaaccc tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct     3720

ggcgtaatag cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg     3780

gcgaatgccg ttaacggatt cttgaagacg aaagggcctc gtgatacgcc tatttttata     3840

ggttaatgtc atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt     3900

gcgcggaacc cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag     3960

acaataaccc tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca     4020

tttccgtgtc gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc     4080

agaaacgctg gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat     4140

cgaactggat ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc     4200

aatgatgagc acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg     4260

gcaagagcaa ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc     4320

agtcacagaa aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat     4380

aaccatgagt gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga     4440

gctaaccgct tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc     4500

ggagctgaat gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc     4560

aacaacgttg cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt     4620

aatagactgg atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc     4680

tggctggttt attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc     4740

agcactgggg ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca     4800

ggcaactatg gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca     4860

ttggtaactg tcagaccaag tttactcata tatactttag attgatttaa aacttcattt     4920

ttaatttaaa aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta     4980

acgtgagttt tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg     5040

agatcctttt tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc     5100

ggtggtttgt ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag     5160

cagagcgcag ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa     5220

gaactctgta gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc     5280

cagtggcgat aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc     5340

gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta     5400

caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag     5460

aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct     5520

tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga     5580

gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc     5640

ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt     5700

atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg     5760

cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg     5820

gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac     5880

aatctgctct gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg     5940

gtcatggctg cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg     6000

ctcccggcat ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg     6060

ttttcaccgt catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg     6120

tgaagcgatt cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga     6180

agcgttaatg tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg     6240

gtcactgatg cctccgtgta agggggattt ctgttcatgg gggtaatgat accgatgaaa     6300

cgagagagga tgctcacgat acgggttact gatgatgaac atgcccggtt actggaacgt     6360

tgtgagggta aacaactggc ggtatggatg cggcgggacc agagaaaaat cactcagggt     6420

caatgccagc gcttcgttaa tacagatgta ggtgttccac agggtagcca gcagcatcct     6480

gcgatgcaga tccggaacat aatggtgcag ggcgctgact tccgcgtttc cagactttac     6540

gaaacacgga aaccgaagac cattcatgtt gttgctcagg tcgcagacgt tttgcagcag     6600

cagtcgcttc acgttcgctc gcgtatcggt gattcattct gctaaccagt aaggcaaccc     6660

cgccagccta gccgggtcct caacgacagg agcacgatca tgcgcacccg tggccaggac     6720

ccaacgctgc ccgccgttaa cggccaatac gcaaaccgcc tctccccgcg cgttgga        6777


<210>  195
<211>  513
<212>  DNA
<213>  Escherichia coli

<400>  195
atgaatataa acaaaccatt agagattctt gggcatgtat cctggctatg ggccagttct       60

ccactacaca gaaactggcc agtatctttg tttgcaataa atgtattacc cgcaatacag      120

gctaaccaat atgttttatt aacccgggat gattaccctg tcgcgtattg tagttgggct      180

aatttaagtt tagaaaatga aattaaatat cttaatgatg ttacctcatt agttgcagaa      240

gactggactt caggtgatcg taaatggttc attgactgga ttgctccttt cggggataac      300

ggtgccctgt acaaatatat gcgaaaaaaa ttccctgatg aactattcag agccatcagg      360

gtggatccca aaactcatgt tggtaaagta tcagaatttc atggaggtaa aattgataaa      420

cagttagcga ataaaatttt taaacaatat caccacgagt taataactga agtaaaaaga      480

aagtcagatt ttaatttttc attaactggt taa                                   513


<210>  196
<211>  170
<212>  PRT
<213>  Escherichia coli

<400>  196

Met Asn Ile Asn Lys Pro Leu Glu Ile Leu Gly His Val Ser Trp Leu 
1               5                   10                  15      


Trp Ala Ser Ser Pro Leu His Arg Asn Trp Pro Val Ser Leu Phe Ala 
            20                  25                  30          


Ile Asn Val Leu Pro Ala Ile Gln Ala Asn Gln Tyr Val Leu Leu Thr 
        35                  40                  45              


Arg Asp Asp Tyr Pro Val Ala Tyr Cys Ser Trp Ala Asn Leu Ser Leu 
    50                  55                  60                  


Glu Asn Glu Ile Lys Tyr Leu Asn Asp Val Thr Ser Leu Val Ala Glu 
65                  70                  75                  80  


Asp Trp Thr Ser Gly Asp Arg Lys Trp Phe Ile Asp Trp Ile Ala Pro 
                85                  90                  95      


Phe Gly Asp Asn Gly Ala Leu Tyr Lys Tyr Met Arg Lys Lys Phe Pro 
            100                 105                 110         


Asp Glu Leu Phe Arg Ala Ile Arg Val Asp Pro Lys Thr His Val Gly 
        115                 120                 125             


Lys Val Ser Glu Phe His Gly Gly Lys Ile Asp Lys Gln Leu Ala Asn 
    130                 135                 140                 


Lys Ile Phe Lys Gln Tyr His His Glu Leu Ile Thr Glu Val Lys Arg 
145                 150                 155                 160 


Lys Ser Asp Phe Asn Phe Ser Leu Thr Gly 
                165                 170 


<210>  197
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  197
gaggtaatta aatgggaaat tctc                                              24


<210>  198
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  198
gctcgaattc gtaatcatg                                                    19


<210>  199
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  199
attacgaatt cgagcatgaa tataaacaaa ccattagaga t                           41


<210>  200
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  200
ccatttaatt acctcttaac cagttaatga aaaattaaaa tc                          42


<210>  201
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  201
gctcgaattc gtaatcatg                                                    19


<210>  202
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  202
gaatataaac aaaccattag agattc                                            26


<210>  203
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  203
acacagaaac tggcca                                                       16


<210>  204
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  204
ccaatatgtt ttattaaccc gg                                                22


<210>  205
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  205
aagtttagaa aatgaaatta aatatcttaa t                                      31


<210>  206
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  206
gacttcaggt gatcgtaaat                                                   20


<210>  207
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  207
cctgtacaaa tatatgcgaa aaa                                               23


<210>  208
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  208
gaaacagcta tgacattatt acgaattcga gcatg                                  35


<210>  209
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  209
catgctcgaa ttcgtaataa tgtcatagct gtttc                                  35


<210>  210
<211>  4910
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  210
tgattacgaa ttcgagcatg aatataaaca aaccattaga gattcttggg catgtatcct       60

ggctatgggc cagttctcca ctacacagaa actggccagt atctttgttt gcaataaatg      120

tattacccgc aatacaggct aaccaatatg ttttattaac ccgggatgat taccctgtcg      180

cgtattgtag ttgggctaat ttaagtttag aaaatgaaat taaatatctt aatgatgtta      240

cctcattagt tgcagaagac tggacttcag gtgatcgtaa atggttcatt gactggattg      300

ctcctttcgg ggataacggt gccctgtaca aatatatgcg aaaaaaattc cctgatgaac      360

tattcagagc catcagggtg gatcccaaaa ctcatgttgg taaagtatca gaatttcatg      420

gaggtaaaat tgataaacag ttagcgaata aaatttttaa acaatatcac cacgagttaa      480

taactgaagt aaaaagaaag tcagatttta atttttcatt aactggttaa gaggtaatta      540

aatgggaaat tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta      600

cggcagtgag ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg      660

atatggtaat gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga      720

tggggggaaa gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa      780

gcgagaaggt aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca      840

taaaaatggt attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca      900

ccagatagag cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa      960

ggcacttgag tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt     1020

agcctatgga agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc     1080

agctgcaggt agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc     1140

cggtaatgcc agtgattttt catatggacg gaactcaata accctgacca catcagcata     1200

atatattaat ttaaatgata gcaatcttac tgggctgtgc cacataagat tgctattttt     1260

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1320

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgataca     1380

gacgggacag gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1440

gtaaaacagg taaaaaaaac aattgatcga tgataagctg tcaaacatga gaattacaac     1500

ttatatcgta tggggctgac ttcaggtgct acatttgaag agataaattg cactgaaatc     1560

ctgcaggcat gcaagcttgg cactggccgt cgttttacaa cgtcgtgact gggaaaaccc     1620

tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag     1680

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatgccg     1740

ttaacggatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     1800

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     1860

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     1920

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     1980

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     2040

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat     2100

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     2160

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa     2220

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa     2280

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     2340

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     2400

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     2460

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg     2520

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     2580

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     2640

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg     2700

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     2760

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     2820

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     2880

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     2940

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     3000

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     3060

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     3120

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     3180

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     3240

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     3300

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     3360

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     3420

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     3480

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     3540

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     3600

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     3660

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     3720

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg gtattttctc     3780

cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac aatctgctct     3840

gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg gtcatggctg     3900

cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     3960

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     4020

catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg tgaagcgatt     4080

cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga agcgttaatg     4140

tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg gtcactgatg     4200

cctccgtgta agggggattt ctgttcatgg gggtaatgat accgatgaaa cgagagagga     4260

tgctcacgat acgggttact gatgatgaac atgcccggtt actggaacgt tgtgagggta     4320

aacaactggc ggtatggatg cggcgggacc agagaaaaat cactcagggt caatgccagc     4380

gcttcgttaa tacagatgta ggtgttccac agggtagcca gcagcatcct gcgatgcaga     4440

tccggaacat aatggtgcag ggcgctgact tccgcgtttc cagactttac gaaacacgga     4500

aaccgaagac cattcatgtt gttgctcagg tcgcagacgt tttgcagcag cagtcgcttc     4560

acgttcgctc gcgtatcggt gattcattct gctaaccagt aaggcaaccc cgccagccta     4620

gccgggtcct caacgacagg agcacgatca tgcgcacccg tggccaggac ccaacgctgc     4680

ccgccgttaa cggccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     4740

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     4800

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt     4860

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgaca                4910


<210>  211
<211>  4910
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  211
ttattacgaa ttcgagcatg aatataaaca aaccattaga gattcttggg catgtatcct       60

ggctatgggc cagttctcca ctacacagaa actggccagt atctttgttt gcaataaatg      120

tattacccgc aatacaggct aaccaatatg ttttattaac ccgggatgat taccctgtcg      180

cgtattgtag ttgggctaat ttaagtttag aaaatgaaat taaatatctt aatgatgtta      240

cctcattagt tgcagaagac tggacttcag gtgatcgtaa atggttcatt gactggattg      300

ctcctttcgg ggataacggt gccctgtaca aatatatgcg aaaaaaattc cctgatgaac      360

tattcagagc catcagggtg gatcccaaaa ctcatgttgg taaagtatca gaatttcatg      420

gaggtaaaat tgataaacag ttagcgaata aaatttttaa acaatatcac cacgagttaa      480

taactgaagt aaaaagaaag tcagatttta atttttcatt aactggttaa gaggtaatta      540

aatgggaaat tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta      600

cggcagtgag ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg      660

atatggtaat gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga      720

tggggggaaa gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa      780

gcgagaaggt aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca      840

taaaaatggt attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca      900

ccagatagag cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa      960

ggcacttgag tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt     1020

agcctatgga agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc     1080

agctgcaggt agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc     1140

cggtaatgcc agtgattttt catatggacg gaactcaata accctgacca catcagcata     1200

atatattaat ttaaatgata gcaatcttac tgggctgtgc cacataagat tgctattttt     1260

tttggagtca taatggattc ttgtcataaa attgattatg ggttatacgc cctggagatt     1320

ttagcccaat accataacgt ctctgttaac ccggaagaaa ttaaacatag atttgataca     1380

gacgggacag gtctgggatt aacgtcatgg ttgcttgctg cgaaatcttt agaactaaag     1440

gtaaaacagg taaaaaaaac aattgatcga tgataagctg tcaaacatga gaattacaac     1500

ttatatcgta tggggctgac ttcaggtgct acatttgaag agataaattg cactgaaatc     1560

ctgcaggcat gcaagcttgg cactggccgt cgttttacaa cgtcgtgact gggaaaaccc     1620

tggcgttacc caacttaatc gccttgcagc acatccccct ttcgccagct ggcgtaatag     1680

cgaagaggcc cgcaccgatc gcccttccca acagttgcgc agcctgaatg gcgaatgccg     1740

ttaacggatt cttgaagacg aaagggcctc gtgatacgcc tatttttata ggttaatgtc     1800

atgataataa tggtttctta gacgtcaggt ggcacttttc ggggaaatgt gcgcggaacc     1860

cctatttgtt tatttttcta aatacattca aatatgtatc cgctcatgag acaataaccc     1920

tgataaatgc ttcaataata ttgaaaaagg aagagtatga gtattcaaca tttccgtgtc     1980

gcccttattc ccttttttgc ggcattttgc cttcctgttt ttgctcaccc agaaacgctg     2040

gtgaaagtaa aagatgctga agatcagttg ggtgcacgag tgggttacat cgaactggat     2100

ctcaacagcg gtaagatcct tgagagtttt cgccccgaag aacgttttcc aatgatgagc     2160

acttttaaag ttctgctatg tggcgcggta ttatcccgta ttgacgccgg gcaagagcaa     2220

ctcggtcgcc gcatacacta ttctcagaat gacttggttg agtactcacc agtcacagaa     2280

aagcatctta cggatggcat gacagtaaga gaattatgca gtgctgccat aaccatgagt     2340

gataacactg cggccaactt acttctgaca acgatcggag gaccgaagga gctaaccgct     2400

tttttgcaca acatggggga tcatgtaact cgccttgatc gttgggaacc ggagctgaat     2460

gaagccatac caaacgacga gcgtgacacc acgatgcctg tagcaatggc aacaacgttg     2520

cgcaaactat taactggcga actacttact ctagcttccc ggcaacaatt aatagactgg     2580

atggaggcgg ataaagttgc aggaccactt ctgcgctcgg cccttccggc tggctggttt     2640

attgctgata aatctggagc cggtgagcgt gggtctcgcg gtatcattgc agcactgggg     2700

ccagatggta agccctcccg tatcgtagtt atctacacga cggggagtca ggcaactatg     2760

gatgaacgaa atagacagat cgctgagata ggtgcctcac tgattaagca ttggtaactg     2820

tcagaccaag tttactcata tatactttag attgatttaa aacttcattt ttaatttaaa     2880

aggatctagg tgaagatcct ttttgataat ctcatgacca aaatccctta acgtgagttt     2940

tcgttccact gagcgtcaga ccccgtagaa aagatcaaag gatcttcttg agatcctttt     3000

tttctgcgcg taatctgctg cttgcaaaca aaaaaaccac cgctaccagc ggtggtttgt     3060

ttgccggatc aagagctacc aactcttttt ccgaaggtaa ctggcttcag cagagcgcag     3120

ataccaaata ctgtccttct agtgtagccg tagttaggcc accacttcaa gaactctgta     3180

gcaccgccta catacctcgc tctgctaatc ctgttaccag tggctgctgc cagtggcgat     3240

aagtcgtgtc ttaccgggtt ggactcaaga cgatagttac cggataaggc gcagcggtcg     3300

ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta caccgaactg     3360

agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag aaaggcggac     3420

aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct tccaggggga     3480

aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga gcgtcgattt     3540

ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc ggccttttta     3600

cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt atcccctgat     3660

tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg cagccgaacg     3720

accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg gtattttctc     3780

cttacgcatc tgtgcggtat ttcacaccgc atatggtgca ctctcagtac aatctgctct     3840

gatgccgcat agttaagcca gtatacactc cgctatcgct acgtgactgg gtcatggctg     3900

cgccccgaca cccgccaaca cccgctgacg cgccctgacg ggcttgtctg ctcccggcat     3960

ccgcttacag acaagctgtg accgtctccg ggagctgcat gtgtcagagg ttttcaccgt     4020

catcaccgaa acgcgcgagg cagctgcggt aaagctcatc agcgtggtcg tgaagcgatt     4080

cacagatgtc tgcctgttca tccgcgtcca gctcgttgag tttctccaga agcgttaatg     4140

tctggcttct gataaagcgg gccatgttaa gggcggtttt ttcctgtttg gtcactgatg     4200

cctccgtgta agggggattt ctgttcatgg gggtaatgat accgatgaaa cgagagagga     4260

tgctcacgat acgggttact gatgatgaac atgcccggtt actggaacgt tgtgagggta     4320

aacaactggc ggtatggatg cggcgggacc agagaaaaat cactcagggt caatgccagc     4380

gcttcgttaa tacagatgta ggtgttccac agggtagcca gcagcatcct gcgatgcaga     4440

tccggaacat aatggtgcag ggcgctgact tccgcgtttc cagactttac gaaacacgga     4500

aaccgaagac cattcatgtt gttgctcagg tcgcagacgt tttgcagcag cagtcgcttc     4560

acgttcgctc gcgtatcggt gattcattct gctaaccagt aaggcaaccc cgccagccta     4620

gccgggtcct caacgacagg agcacgatca tgcgcacccg tggccaggac ccaacgctgc     4680

ccgccgttaa cggccaatac gcaaaccgcc tctccccgcg cgttggccga ttcattaatg     4740

cagctggcac gacaggtttc ccgactggaa agcgggcagt gagcgcaacg caattaatgt     4800

gagttagctc actcattagg caccccaggc tttacacttt atgcttccgg ctcgtatgtt     4860

gtgtggaatt gtgagcggat aacaatttca cacaggaaac agctatgaca                4910


<210>  212
<211>  4908
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  212
tgattacgaa ttcgagcgaa tataaacaaa ccattagaga ttcttgggca tgtatcctgg       60

ctatgggcca gttctccact acacagaaac tggccagtat ctttgtttgc aataaatgta      120

ttacccgcaa tacaggctaa ccaatatgtt ttattaaccc gggatgatta ccctgtcgcg      180

tattgtagtt gggctaattt aagtttagaa aatgaaatta aatatcttaa tgatgttacc      240

tcattagttg cagaagactg gacttcaggt gatcgtaaat ggttcattga ctggattgct      300

cctttcgggg ataacggtgc cctgtacaaa tatatgcgaa aaaaattccc tgatgaacta      360

ttcagagcca tcagggtgga tcccaaaact catgttggta aagtatcaga atttcatgga      420

ggtaaaattg ataaacagtt agcgaataaa atttttaaac aatatcacca cgagttaata      480

actgaagtaa aaagaaagtc agattttaat ttttcattaa ctggttaaga ggtaattaaa      540

tgggaaattc tcttgcaaaa aatgtattat tcggtggaaa aggtaatgac aagctgtacg      600

gcagtgaggg ggcagatctg cttgatggtg gagaggggga tgatctcctg aaaggcggat      660

atggtaatga tatttatcgt tatctgtcag gatatggtca tcatattatt gatgatgatg      720

gggggaaaga ggataaactc agtttggctg atattgattt ccgggatgtg gccttcaagc      780

gagaaggtaa tgacctcatc atgtataaag ctgaaggtaa tgttctttcc attggtcata      840

aaaatggtat tacattcagg aactggtttg aaaaagagtc aggtgatatc tctaatcacc      900

agatagagca gatttttgat aaaagtggcc ggataatcac acctgattcc cttaaaaagg      960

cacttgagta tcaacagcgt aataataagg caagttatgt gtatgggaat gatgcattag     1020

cctatggaag tcagggtgat cttaatccat taattaatga aatcagcaaa atcatttcag     1080

ctgcaggtag cttcgatgtt aaagaggaaa gaactgcagc ttctttattg cagttgtccg     1140

gtaatgccag tgatttttca tatggacgga actcaataac cctgaccaca tcagcataat     1200

atattaattt aaatgatagc aatcttactg ggctgtgcca cataagattg ctattttttt     1260

tggagtcata atggattctt gtcataaaat tgattatggg ttatacgccc tggagatttt     1320

agcccaatac cataacgtct ctgttaaccc ggaagaaatt aaacatagat ttgatacaga     1380

cgggacaggt ctgggattaa cgtcatggtt gcttgctgcg aaatctttag aactaaaggt     1440

aaaacaggta aaaaaaacaa ttgatcgatg ataagctgtc aaacatgaga attacaactt     1500

atatcgtatg gggctgactt caggtgctac atttgaagag ataaattgca ctgaaatcct     1560

gcaggcatgc aagcttggca ctggccgtcg ttttacaacg tcgtgactgg gaaaaccctg     1620

gcgttaccca acttaatcgc cttgcagcac atcccccttt cgccagctgg cgtaatagcg     1680

aagaggcccg caccgatcgc ccttcccaac agttgcgcag cctgaatggc gaatgccgtt     1740

aacggattct tgaagacgaa agggcctcgt gatacgccta tttttatagg ttaatgtcat     1800

gataataatg gtttcttaga cgtcaggtgg cacttttcgg ggaaatgtgc gcggaacccc     1860

tatttgttta tttttctaaa tacattcaaa tatgtatccg ctcatgagac aataaccctg     1920

ataaatgctt caataatatt gaaaaaggaa gagtatgagt attcaacatt tccgtgtcgc     1980

ccttattccc ttttttgcgg cattttgcct tcctgttttt gctcacccag aaacgctggt     2040

gaaagtaaaa gatgctgaag atcagttggg tgcacgagtg ggttacatcg aactggatct     2100

caacagcggt aagatccttg agagttttcg ccccgaagaa cgttttccaa tgatgagcac     2160

ttttaaagtt ctgctatgtg gcgcggtatt atcccgtatt gacgccgggc aagagcaact     2220

cggtcgccgc atacactatt ctcagaatga cttggttgag tactcaccag tcacagaaaa     2280

gcatcttacg gatggcatga cagtaagaga attatgcagt gctgccataa ccatgagtga     2340

taacactgcg gccaacttac ttctgacaac gatcggagga ccgaaggagc taaccgcttt     2400

tttgcacaac atgggggatc atgtaactcg ccttgatcgt tgggaaccgg agctgaatga     2460

agccatacca aacgacgagc gtgacaccac gatgcctgta gcaatggcaa caacgttgcg     2520

caaactatta actggcgaac tacttactct agcttcccgg caacaattaa tagactggat     2580

ggaggcggat aaagttgcag gaccacttct gcgctcggcc cttccggctg gctggtttat     2640

tgctgataaa tctggagccg gtgagcgtgg gtctcgcggt atcattgcag cactggggcc     2700

agatggtaag ccctcccgta tcgtagttat ctacacgacg gggagtcagg caactatgga     2760

tgaacgaaat agacagatcg ctgagatagg tgcctcactg attaagcatt ggtaactgtc     2820

agaccaagtt tactcatata tactttagat tgatttaaaa cttcattttt aatttaaaag     2880

gatctaggtg aagatccttt ttgataatct catgaccaaa atcccttaac gtgagttttc     2940

gttccactga gcgtcagacc ccgtagaaaa gatcaaagga tcttcttgag atcctttttt     3000

tctgcgcgta atctgctgct tgcaaacaaa aaaaccaccg ctaccagcgg tggtttgttt     3060

gccggatcaa gagctaccaa ctctttttcc gaaggtaact ggcttcagca gagcgcagat     3120

accaaatact gtccttctag tgtagccgta gttaggccac cacttcaaga actctgtagc     3180

accgcctaca tacctcgctc tgctaatcct gttaccagtg gctgctgcca gtggcgataa     3240

gtcgtgtctt accgggttgg actcaagacg atagttaccg gataaggcgc agcggtcggg     3300

ctgaacgggg ggttcgtgca cacagcccag cttggagcga acgacctaca ccgaactgag     3360

atacctacag cgtgagctat gagaaagcgc cacgcttccc gaagggagaa aggcggacag     3420

gtatccggta agcggcaggg tcggaacagg agagcgcacg agggagcttc cagggggaaa     3480

cgcctggtat ctttatagtc ctgtcgggtt tcgccacctc tgacttgagc gtcgattttt     3540

gtgatgctcg tcaggggggc ggagcctatg gaaaaacgcc agcaacgcgg cctttttacg     3600

gttcctggcc ttttgctggc cttttgctca catgttcttt cctgcgttat cccctgattc     3660

tgtggataac cgtattaccg cctttgagtg agctgatacc gctcgccgca gccgaacgac     3720

cgagcgcagc gagtcagtga gcgaggaagc ggaagagcgc ctgatgcggt attttctcct     3780

tacgcatctg tgcggtattt cacaccgcat atggtgcact ctcagtacaa tctgctctga     3840

tgccgcatag ttaagccagt atacactccg ctatcgctac gtgactgggt catggctgcg     3900

ccccgacacc cgccaacacc cgctgacgcg ccctgacggg cttgtctgct cccggcatcc     3960

gcttacagac aagctgtgac cgtctccggg agctgcatgt gtcagaggtt ttcaccgtca     4020

tcaccgaaac gcgcgaggca gctgcggtaa agctcatcag cgtggtcgtg aagcgattca     4080

cagatgtctg cctgttcatc cgcgtccagc tcgttgagtt tctccagaag cgttaatgtc     4140

tggcttctga taaagcgggc catgttaagg gcggtttttt cctgtttggt cactgatgcc     4200

tccgtgtaag ggggatttct gttcatgggg gtaatgatac cgatgaaacg agagaggatg     4260

ctcacgatac gggttactga tgatgaacat gcccggttac tggaacgttg tgagggtaaa     4320

caactggcgg tatggatgcg gcgggaccag agaaaaatca ctcagggtca atgccagcgc     4380

ttcgttaata cagatgtagg tgttccacag ggtagccagc agcatcctgc gatgcagatc     4440

cggaacataa tggtgcaggg cgctgacttc cgcgtttcca gactttacga aacacggaaa     4500

ccgaagacca ttcatgttgt tgctcaggtc gcagacgttt tgcagcagca gtcgcttcac     4560

gttcgctcgc gtatcggtga ttcattctgc taaccagtaa ggcaaccccg ccagcctagc     4620

cgggtcctca acgacaggag cacgatcatg cgcacccgtg gccaggaccc aacgctgccc     4680

gccgttaacg gccaatacgc aaaccgcctc tccccgcgcg ttggccgatt cattaatgca     4740

gctggcacga caggtttccc gactggaaag cgggcagtga gcgcaacgca attaatgtga     4800

gttagctcac tcattaggca ccccaggctt tacactttat gcttccggct cgtatgttgt     4860

gtggaattgt gagcggataa caatttcaca caggaaacag ctatgaca                  4908


<210>  213
<211>  4845
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  213
tgattacgaa ttcgagcaca cagaaactgg ccagtatctt tgtttgcaat aaatgtatta       60

cccgcaatac aggctaacca atatgtttta ttaacccggg atgattaccc tgtcgcgtat      120

tgtagttggg ctaatttaag tttagaaaat gaaattaaat atcttaatga tgttacctca      180

ttagttgcag aagactggac ttcaggtgat cgtaaatggt tcattgactg gattgctcct      240

ttcggggata acggtgccct gtacaaatat atgcgaaaaa aattccctga tgaactattc      300

agagccatca gggtggatcc caaaactcat gttggtaaag tatcagaatt tcatggaggt      360

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      420

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatgg      480

gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag ctgtacggca      540

gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa ggcggatatg      600

gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat gatgatgggg      660

ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc ttcaagcgag      720

aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt ggtcataaaa      780

atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct aatcaccaga      840

tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt aaaaaggcac      900

ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat gcattagcct      960

atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc atttcagctg     1020

caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag ttgtccggta     1080

atgccagtga tttttcatat ggacggaact caataaccct gaccacatca gcataatata     1140

ttaatttaaa tgatagcaat cttactgggc tgtgccacat aagattgcta ttttttttgg     1200

agtcataatg gattcttgtc ataaaattga ttatgggtta tacgccctgg agattttagc     1260

ccaataccat aacgtctctg ttaacccgga agaaattaaa catagatttg atacagacgg     1320

gacaggtctg ggattaacgt catggttgct tgctgcgaaa tctttagaac taaaggtaaa     1380

acaggtaaaa aaaacaattg atcgatgata agctgtcaaa catgagaatt acaacttata     1440

tcgtatgggg ctgacttcag gtgctacatt tgaagagata aattgcactg aaatcctgca     1500

ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     1560

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     1620

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgccgttaac     1680

ggattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1740

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1800

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1860

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1920

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1980

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     2040

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     2100

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     2160

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     2220

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     2280

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2340

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2400

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2460

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2520

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2580

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     2640

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2700

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2760

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2820

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2880

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2940

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     3000

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     3060

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     3120

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     3180

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     3240

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3300

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3360

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3420

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3480

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3540

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     3600

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     3660

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     3720

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3780

cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc     3840

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     3900

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     3960

ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag     4020

atgtctgcct gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg     4080

cttctgataa agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc     4140

gtgtaagggg gatttctgtt catgggggta atgataccga tgaaacgaga gaggatgctc     4200

acgatacggg ttactgatga tgaacatgcc cggttactgg aacgttgtga gggtaaacaa     4260

ctggcggtat ggatgcggcg ggaccagaga aaaatcactc agggtcaatg ccagcgcttc     4320

gttaatacag atgtaggtgt tccacagggt agccagcagc atcctgcgat gcagatccgg     4380

aacataatgg tgcagggcgc tgacttccgc gtttccagac tttacgaaac acggaaaccg     4440

aagaccattc atgttgttgc tcaggtcgca gacgttttgc agcagcagtc gcttcacgtt     4500

cgctcgcgta tcggtgattc attctgctaa ccagtaaggc aaccccgcca gcctagccgg     4560

gtcctcaacg acaggagcac gatcatgcgc acccgtggcc aggacccaac gctgcccgcc     4620

gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4680

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     4740

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     4800

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaca                     4845


<210>  214
<211>  4785
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  214
tgattacgaa ttcgagccca atatgtttta ttaacccggg atgattaccc tgtcgcgtat       60

tgtagttggg ctaatttaag tttagaaaat gaaattaaat atcttaatga tgttacctca      120

ttagttgcag aagactggac ttcaggtgat cgtaaatggt tcattgactg gattgctcct      180

ttcggggata acggtgccct gtacaaatat atgcgaaaaa aattccctga tgaactattc      240

agagccatca gggtggatcc caaaactcat gttggtaaag tatcagaatt tcatggaggt      300

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      360

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatgg      420

gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag ctgtacggca      480

gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa ggcggatatg      540

gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat gatgatgggg      600

ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc ttcaagcgag      660

aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt ggtcataaaa      720

atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct aatcaccaga      780

tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt aaaaaggcac      840

ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat gcattagcct      900

atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc atttcagctg      960

caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag ttgtccggta     1020

atgccagtga tttttcatat ggacggaact caataaccct gaccacatca gcataatata     1080

ttaatttaaa tgatagcaat cttactgggc tgtgccacat aagattgcta ttttttttgg     1140

agtcataatg gattcttgtc ataaaattga ttatgggtta tacgccctgg agattttagc     1200

ccaataccat aacgtctctg ttaacccgga agaaattaaa catagatttg atacagacgg     1260

gacaggtctg ggattaacgt catggttgct tgctgcgaaa tctttagaac taaaggtaaa     1320

acaggtaaaa aaaacaattg atcgatgata agctgtcaaa catgagaatt acaacttata     1380

tcgtatgggg ctgacttcag gtgctacatt tgaagagata aattgcactg aaatcctgca     1440

ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     1500

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     1560

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgccgttaac     1620

ggattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1680

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1740

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1800

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1860

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1920

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     1980

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     2040

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     2100

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     2160

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     2220

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2280

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2340

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2400

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2460

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2520

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     2580

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2640

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2700

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2760

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2820

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2880

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     2940

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     3000

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     3060

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     3120

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     3180

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3240

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3300

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3360

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3420

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3480

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     3540

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     3600

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     3660

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3720

cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc     3780

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     3840

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     3900

ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag     3960

atgtctgcct gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg     4020

cttctgataa agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc     4080

gtgtaagggg gatttctgtt catgggggta atgataccga tgaaacgaga gaggatgctc     4140

acgatacggg ttactgatga tgaacatgcc cggttactgg aacgttgtga gggtaaacaa     4200

ctggcggtat ggatgcggcg ggaccagaga aaaatcactc agggtcaatg ccagcgcttc     4260

gttaatacag atgtaggtgt tccacagggt agccagcagc atcctgcgat gcagatccgg     4320

aacataatgg tgcagggcgc tgacttccgc gtttccagac tttacgaaac acggaaaccg     4380

aagaccattc atgttgttgc tcaggtcgca gacgttttgc agcagcagtc gcttcacgtt     4440

cgctcgcgta tcggtgattc attctgctaa ccagtaaggc aaccccgcca gcctagccgg     4500

gtcctcaacg acaggagcac gatcatgcgc acccgtggcc aggacccaac gctgcccgcc     4560

gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4620

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     4680

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     4740

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaca                     4785


<210>  215
<211>  4725
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  215
tgattacgaa ttcgagcaag tttagaaaat gaaattaaat atcttaatga tgttacctca       60

ttagttgcag aagactggac ttcaggtgat cgtaaatggt tcattgactg gattgctcct      120

ttcggggata acggtgccct gtacaaatat atgcgaaaaa aattccctga tgaactattc      180

agagccatca gggtggatcc caaaactcat gttggtaaag tatcagaatt tcatggaggt      240

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      300

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatgg      360

gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag ctgtacggca      420

gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa ggcggatatg      480

gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat gatgatgggg      540

ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc ttcaagcgag      600

aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt ggtcataaaa      660

atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct aatcaccaga      720

tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt aaaaaggcac      780

ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat gcattagcct      840

atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc atttcagctg      900

caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag ttgtccggta      960

atgccagtga tttttcatat ggacggaact caataaccct gaccacatca gcataatata     1020

ttaatttaaa tgatagcaat cttactgggc tgtgccacat aagattgcta ttttttttgg     1080

agtcataatg gattcttgtc ataaaattga ttatgggtta tacgccctgg agattttagc     1140

ccaataccat aacgtctctg ttaacccgga agaaattaaa catagatttg atacagacgg     1200

gacaggtctg ggattaacgt catggttgct tgctgcgaaa tctttagaac taaaggtaaa     1260

acaggtaaaa aaaacaattg atcgatgata agctgtcaaa catgagaatt acaacttata     1320

tcgtatgggg ctgacttcag gtgctacatt tgaagagata aattgcactg aaatcctgca     1380

ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     1440

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     1500

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgccgttaac     1560

ggattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1620

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1680

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1740

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1800

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1860

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     1920

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     1980

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     2040

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     2100

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     2160

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2220

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2280

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2340

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2400

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2460

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     2520

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2580

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2640

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2700

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2760

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2820

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     2880

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     2940

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     3000

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     3060

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     3120

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3180

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3240

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3300

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3360

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3420

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     3480

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     3540

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     3600

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3660

cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc     3720

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     3780

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     3840

ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag     3900

atgtctgcct gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg     3960

cttctgataa agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc     4020

gtgtaagggg gatttctgtt catgggggta atgataccga tgaaacgaga gaggatgctc     4080

acgatacggg ttactgatga tgaacatgcc cggttactgg aacgttgtga gggtaaacaa     4140

ctggcggtat ggatgcggcg ggaccagaga aaaatcactc agggtcaatg ccagcgcttc     4200

gttaatacag atgtaggtgt tccacagggt agccagcagc atcctgcgat gcagatccgg     4260

aacataatgg tgcagggcgc tgacttccgc gtttccagac tttacgaaac acggaaaccg     4320

aagaccattc atgttgttgc tcaggtcgca gacgttttgc agcagcagtc gcttcacgtt     4380

cgctcgcgta tcggtgattc attctgctaa ccagtaaggc aaccccgcca gcctagccgg     4440

gtcctcaacg acaggagcac gatcatgcgc acccgtggcc aggacccaac gctgcccgcc     4500

gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4560

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     4620

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     4680

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaca                     4725


<210>  216
<211>  4665
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  216
tgattacgaa ttcgagcgac ttcaggtgat cgtaaatggt tcattgactg gattgctcct       60

ttcggggata acggtgccct gtacaaatat atgcgaaaaa aattccctga tgaactattc      120

agagccatca gggtggatcc caaaactcat gttggtaaag tatcagaatt tcatggaggt      180

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      240

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatgg      300

gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag ctgtacggca      360

gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa ggcggatatg      420

gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat gatgatgggg      480

ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc ttcaagcgag      540

aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt ggtcataaaa      600

atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct aatcaccaga      660

tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt aaaaaggcac      720

ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat gcattagcct      780

atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc atttcagctg      840

caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag ttgtccggta      900

atgccagtga tttttcatat ggacggaact caataaccct gaccacatca gcataatata      960

ttaatttaaa tgatagcaat cttactgggc tgtgccacat aagattgcta ttttttttgg     1020

agtcataatg gattcttgtc ataaaattga ttatgggtta tacgccctgg agattttagc     1080

ccaataccat aacgtctctg ttaacccgga agaaattaaa catagatttg atacagacgg     1140

gacaggtctg ggattaacgt catggttgct tgctgcgaaa tctttagaac taaaggtaaa     1200

acaggtaaaa aaaacaattg atcgatgata agctgtcaaa catgagaatt acaacttata     1260

tcgtatgggg ctgacttcag gtgctacatt tgaagagata aattgcactg aaatcctgca     1320

ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     1380

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     1440

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgccgttaac     1500

ggattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1560

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1620

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1680

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1740

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1800

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     1860

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     1920

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     1980

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     2040

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     2100

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2160

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2220

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2280

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2340

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2400

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     2460

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2520

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2580

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2640

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2700

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2760

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     2820

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     2880

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     2940

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     3000

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     3060

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3120

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3180

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3240

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3300

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3360

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     3420

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     3480

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     3540

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3600

cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc     3660

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     3720

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     3780

ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag     3840

atgtctgcct gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg     3900

cttctgataa agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc     3960

gtgtaagggg gatttctgtt catgggggta atgataccga tgaaacgaga gaggatgctc     4020

acgatacggg ttactgatga tgaacatgcc cggttactgg aacgttgtga gggtaaacaa     4080

ctggcggtat ggatgcggcg ggaccagaga aaaatcactc agggtcaatg ccagcgcttc     4140

gttaatacag atgtaggtgt tccacagggt agccagcagc atcctgcgat gcagatccgg     4200

aacataatgg tgcagggcgc tgacttccgc gtttccagac tttacgaaac acggaaaccg     4260

aagaccattc atgttgttgc tcaggtcgca gacgttttgc agcagcagtc gcttcacgtt     4320

cgctcgcgta tcggtgattc attctgctaa ccagtaaggc aaccccgcca gcctagccgg     4380

gtcctcaacg acaggagcac gatcatgcgc acccgtggcc aggacccaac gctgcccgcc     4440

gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4500

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     4560

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     4620

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaca                     4665


<210>  217
<211>  4605
<212>  DNA
<213>  Artificial

<220>
<223>  modified pSU expression vector

<400>  217
tgattacgaa ttcgagccct gtacaaatat atgcgaaaaa aattccctga tgaactattc       60

agagccatca gggtggatcc caaaactcat gttggtaaag tatcagaatt tcatggaggt      120

aaaattgata aacagttagc gaataaaatt tttaaacaat atcaccacga gttaataact      180

gaagtaaaaa gaaagtcaga ttttaatttt tcattaactg gttaagaggt aattaaatgg      240

gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag ctgtacggca      300

gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa ggcggatatg      360

gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat gatgatgggg      420

ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc ttcaagcgag      480

aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt ggtcataaaa      540

atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct aatcaccaga      600

tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt aaaaaggcac      660

ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat gcattagcct      720

atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc atttcagctg      780

caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag ttgtccggta      840

atgccagtga tttttcatat ggacggaact caataaccct gaccacatca gcataatata      900

ttaatttaaa tgatagcaat cttactgggc tgtgccacat aagattgcta ttttttttgg      960

agtcataatg gattcttgtc ataaaattga ttatgggtta tacgccctgg agattttagc     1020

ccaataccat aacgtctctg ttaacccgga agaaattaaa catagatttg atacagacgg     1080

gacaggtctg ggattaacgt catggttgct tgctgcgaaa tctttagaac taaaggtaaa     1140

acaggtaaaa aaaacaattg atcgatgata agctgtcaaa catgagaatt acaacttata     1200

tcgtatgggg ctgacttcag gtgctacatt tgaagagata aattgcactg aaatcctgca     1260

ggcatgcaag cttggcactg gccgtcgttt tacaacgtcg tgactgggaa aaccctggcg     1320

ttacccaact taatcgcctt gcagcacatc cccctttcgc cagctggcgt aatagcgaag     1380

aggcccgcac cgatcgccct tcccaacagt tgcgcagcct gaatggcgaa tgccgttaac     1440

ggattcttga agacgaaagg gcctcgtgat acgcctattt ttataggtta atgtcatgat     1500

aataatggtt tcttagacgt caggtggcac ttttcgggga aatgtgcgcg gaacccctat     1560

ttgtttattt ttctaaatac attcaaatat gtatccgctc atgagacaat aaccctgata     1620

aatgcttcaa taatattgaa aaaggaagag tatgagtatt caacatttcc gtgtcgccct     1680

tattcccttt tttgcggcat tttgccttcc tgtttttgct cacccagaaa cgctggtgaa     1740

agtaaaagat gctgaagatc agttgggtgc acgagtgggt tacatcgaac tggatctcaa     1800

cagcggtaag atccttgaga gttttcgccc cgaagaacgt tttccaatga tgagcacttt     1860

taaagttctg ctatgtggcg cggtattatc ccgtattgac gccgggcaag agcaactcgg     1920

tcgccgcata cactattctc agaatgactt ggttgagtac tcaccagtca cagaaaagca     1980

tcttacggat ggcatgacag taagagaatt atgcagtgct gccataacca tgagtgataa     2040

cactgcggcc aacttacttc tgacaacgat cggaggaccg aaggagctaa ccgctttttt     2100

gcacaacatg ggggatcatg taactcgcct tgatcgttgg gaaccggagc tgaatgaagc     2160

cataccaaac gacgagcgtg acaccacgat gcctgtagca atggcaacaa cgttgcgcaa     2220

actattaact ggcgaactac ttactctagc ttcccggcaa caattaatag actggatgga     2280

ggcggataaa gttgcaggac cacttctgcg ctcggccctt ccggctggct ggtttattgc     2340

tgataaatct ggagccggtg agcgtgggtc tcgcggtatc attgcagcac tggggccaga     2400

tggtaagccc tcccgtatcg tagttatcta cacgacgggg agtcaggcaa ctatggatga     2460

acgaaataga cagatcgctg agataggtgc ctcactgatt aagcattggt aactgtcaga     2520

ccaagtttac tcatatatac tttagattga tttaaaactt catttttaat ttaaaaggat     2580

ctaggtgaag atcctttttg ataatctcat gaccaaaatc ccttaacgtg agttttcgtt     2640

ccactgagcg tcagaccccg tagaaaagat caaaggatct tcttgagatc ctttttttct     2700

gcgcgtaatc tgctgcttgc aaacaaaaaa accaccgcta ccagcggtgg tttgtttgcc     2760

ggatcaagag ctaccaactc tttttccgaa ggtaactggc ttcagcagag cgcagatacc     2820

aaatactgtc cttctagtgt agccgtagtt aggccaccac ttcaagaact ctgtagcacc     2880

gcctacatac ctcgctctgc taatcctgtt accagtggct gctgccagtg gcgataagtc     2940

gtgtcttacc gggttggact caagacgata gttaccggat aaggcgcagc ggtcgggctg     3000

aacggggggt tcgtgcacac agcccagctt ggagcgaacg acctacaccg aactgagata     3060

cctacagcgt gagctatgag aaagcgccac gcttcccgaa gggagaaagg cggacaggta     3120

tccggtaagc ggcagggtcg gaacaggaga gcgcacgagg gagcttccag ggggaaacgc     3180

ctggtatctt tatagtcctg tcgggtttcg ccacctctga cttgagcgtc gatttttgtg     3240

atgctcgtca ggggggcgga gcctatggaa aaacgccagc aacgcggcct ttttacggtt     3300

cctggccttt tgctggcctt ttgctcacat gttctttcct gcgttatccc ctgattctgt     3360

ggataaccgt attaccgcct ttgagtgagc tgataccgct cgccgcagcc gaacgaccga     3420

gcgcagcgag tcagtgagcg aggaagcgga agagcgcctg atgcggtatt ttctccttac     3480

gcatctgtgc ggtatttcac accgcatatg gtgcactctc agtacaatct gctctgatgc     3540

cgcatagtta agccagtata cactccgcta tcgctacgtg actgggtcat ggctgcgccc     3600

cgacacccgc caacacccgc tgacgcgccc tgacgggctt gtctgctccc ggcatccgct     3660

tacagacaag ctgtgaccgt ctccgggagc tgcatgtgtc agaggttttc accgtcatca     3720

ccgaaacgcg cgaggcagct gcggtaaagc tcatcagcgt ggtcgtgaag cgattcacag     3780

atgtctgcct gttcatccgc gtccagctcg ttgagtttct ccagaagcgt taatgtctgg     3840

cttctgataa agcgggccat gttaagggcg gttttttcct gtttggtcac tgatgcctcc     3900

gtgtaagggg gatttctgtt catgggggta atgataccga tgaaacgaga gaggatgctc     3960

acgatacggg ttactgatga tgaacatgcc cggttactgg aacgttgtga gggtaaacaa     4020

ctggcggtat ggatgcggcg ggaccagaga aaaatcactc agggtcaatg ccagcgcttc     4080

gttaatacag atgtaggtgt tccacagggt agccagcagc atcctgcgat gcagatccgg     4140

aacataatgg tgcagggcgc tgacttccgc gtttccagac tttacgaaac acggaaaccg     4200

aagaccattc atgttgttgc tcaggtcgca gacgttttgc agcagcagtc gcttcacgtt     4260

cgctcgcgta tcggtgattc attctgctaa ccagtaaggc aaccccgcca gcctagccgg     4320

gtcctcaacg acaggagcac gatcatgcgc acccgtggcc aggacccaac gctgcccgcc     4380

gttaacggcc aatacgcaaa ccgcctctcc ccgcgcgttg gccgattcat taatgcagct     4440

ggcacgacag gtttcccgac tggaaagcgg gcagtgagcg caacgcaatt aatgtgagtt     4500

agctcactca ttaggcaccc caggctttac actttatgct tccggctcgt atgttgtgtg     4560

gaattgtgag cggataacaa tttcacacag gaaacagcta tgaca                     4605


<210>  218
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  218
ctgtattttc agggctgtga tctgccgcag actc                                   34


<210>  219
<211>  58
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  219
tgcaagagaa tttccacggc catcaatttc cttacttctt aaactttctt gcaagttt         58


<210>  220
<211>  1365
<212>  DNA
<213>  Artificial

<220>
<223>  HlyC/gap/IFNa2/HlyA1 construct

<400>  220
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgcaccacca ccaccaccac      180

gaaaacctgt attttcaggg ctgtgatctg ccgcagactc actctctggg ttctcgtcgt      240

actctgatgc tgctggctca gatgcgtcgt atctctcttt tctcctgctt gaaggaccgt      300

catgactttg gatttcccca ggaggagttt ggcaaccagt tccaaaaggc tgaaaccatc      360

cctgtcctcc atgagatgat ccagcagatc ttcaatctct tcagcacaaa ggactcatct      420

gctgcttggg atgagaccct cctagacaaa ttctacactg aactctacca gcagctgaat      480

gacctggaag cctgtgtgat acagggggtg ggggtgacag agactcccct gatgaaggag      540

gactccattc tggctgtgag gaaatacttc caaagaatca ctctctatct gaaagagaag      600

aaatacagcc cttgtgcctg ggaggttgtc agagcagaaa tcatgagatc tttttctttg      660

tcaacaaact tgcaagaaag tttaagaagt aaggaaattg atggccgtgg aaattctctt      720

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      780

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      840

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      900

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      960

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca     1020

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt     1080

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa     1140

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag     1200

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc     1260

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1320

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1365


<210>  221
<211>  1206
<212>  DNA
<213>  Artificial

<220>
<223>  IFNa2/HlyA1 construct

<400>  221
atgcaccacc accaccacca cgaaaacctg tattttcagg gctgtgatct gccgcagact       60

cactctctgg gttctcgtcg tactctgatg ctgctggctc agatgcgtcg tatctctctt      120

ttctcctgct tgaaggaccg tcatgacttt ggatttcccc aggaggagtt tggcaaccag      180

ttccaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcaatctc      240

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      300

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      360

gagactcccc tgatgaagga ggactccatt ctggctgtga ggaaatactt ccaaagaatc      420

actctctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      480

atcatgagat ctttttcttt gtcaacaaac ttgcaagaaa gtttaagaag taaggaaatt      540

gatggccgtg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag      600

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa      660

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat      720

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc      780

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt      840

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct      900

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt      960

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat     1020

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc     1080

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag     1140

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca     1200

gcataa                                                                1206


<210>  222
<211>  401
<212>  PRT
<213>  Artificial

<220>
<223>  His-IFNa2-TEV-HlyA1 fusion

<400>  222

Met His His His His His His Glu Asn Leu Tyr Phe Gln Gly Cys Asp 
1               5                   10                  15      


Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu 
            20                  25                  30          


Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His 
        35                  40                  45              


Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala 
    50                  55                  60                  


Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu 
65                  70                  75                  80  


Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp 
                85                  90                  95      


Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys 
            100                 105                 110         


Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp 
        115                 120                 125             


Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu 
    130                 135                 140                 


Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu 
145                 150                 155                 160 


Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg 
                165                 170                 175     


Ser Lys Glu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu 
            180                 185                 190         


Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp 
        195                 200                 205             


Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly 
    210                 215                 220                 


Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp 
225                 230                 235                 240 


Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe 
                245                 250                 255     


Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys 
            260                 265                 270         


Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe 
        275                 280                 285             


Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile 
    290                 295                 300                 


Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu 
305                 310                 315                 320 


Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val 
                325                 330                 335     


Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro 
            340                 345                 350         


Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp 
        355                 360                 365             


Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn 
    370                 375                 380                 


Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser 
385                 390                 395                 400 


Ala 
    


<210>  223
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  223
ggaaattctc ttgcaaaaaa tgtatta                                           27


<210>  224
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  224
gccctgaaaa tacaggtttt cgtggtggtg gtggtggtgc atttaattac ctcttaacca       60

gttaatg                                                                 67


<210>  225
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  225
agaggtaatt aaatgtgtga tctgccgcag actc                                   34


<210>  226
<211>  46
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  226
gtgacggcca tcaatttcct tacttcttaa actttcttgc aagttt                      46


<210>  227
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  227
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgtgatct gccgcagact      180

cactctctgg gttctcgtcg tactctgatg ctgctggctc agatgcgtcg tatctctctt      240

ttctcctgct tgaaggaccg tcatgacttt ggatttcccc aggaggagtt tggcaaccag      300

ttccaaaagg ctgaaaccat ccctgtcctc catgagatga tccagcagat cttcaatctc      360

ttcagcacaa aggactcatc tgctgcttgg gatgagaccc tcctagacaa attctacact      420

gaactctacc agcagctgaa tgacctggaa gcctgtgtga tacagggggt gggggtgaca      480

gagactcccc tgatgaagga ggactccatt ctggctgtga ggaaatactt ccaaagaatc      540

actctctatc tgaaagagaa gaaatacagc ccttgtgcct gggaggttgt cagagcagaa      600

atcatgagat ctttttcttt gtcaacaaac ttgcaagaaa gtttaagaag taaggaaatt      660

gatggccgtc accaccacca ccaccacgga aattctcttg caaaaaatgt attattcggt      720

ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga tggtggagag      780

ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct gtcaggatat      840

ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt ggctgatatt      900

gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta taaagctgaa      960

ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg gtttgaaaaa     1020

gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag tggccggata     1080

atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa taaggcaagt     1140

tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa tccattaatt     1200

aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga ggaaagaact     1260

gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg acggaactca     1320

ataaccctga ccacatcagc ataa                                            1344


<210>  228
<211>  1185
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  228
atgtgtgatc tgccgcagac tcactctctg ggttctcgtc gtactctgat gctgctggct       60

cagatgcgtc gtatctctct tttctcctgc ttgaaggacc gtcatgactt tggatttccc      120

caggaggagt ttggcaacca gttccaaaag gctgaaacca tccctgtcct ccatgagatg      180

atccagcaga tcttcaatct cttcagcaca aaggactcat ctgctgcttg ggatgagacc      240

ctcctagaca aattctacac tgaactctac cagcagctga atgacctgga agcctgtgtg      300

atacaggggg tgggggtgac agagactccc ctgatgaagg aggactccat tctggctgtg      360

aggaaatact tccaaagaat cactctctat ctgaaagaga agaaatacag cccttgtgcc      420

tgggaggttg tcagagcaga aatcatgaga tctttttctt tgtcaacaaa cttgcaagaa      480

agtttaagaa gtaaggaaat tgatggccgt caccaccacc accaccacgg aaattctctt      540

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      600

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      660

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      720

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      780

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca      840

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt      900

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa      960

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag     1020

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc     1080

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1140

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1185


<210>  229
<211>  394
<212>  PRT
<213>  Artificial

<220>
<223>  IFNa2-HlyA1 fusion protein

<400>  229

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Ser Arg Arg Thr Leu 
1               5                   10                  15      


Met Leu Leu Ala Gln Met Arg Arg Ile Ser Leu Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Gly Asn Gln Phe 
        35                  40                  45              


Gln Lys Ala Glu Thr Ile Pro Val Leu His Glu Met Ile Gln Gln Ile 
    50                  55                  60                  


Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu Thr 
65                  70                  75                  80  


Leu Leu Asp Lys Phe Tyr Thr Glu Leu Tyr Gln Gln Leu Asn Asp Leu 
                85                  90                  95      


Glu Ala Cys Val Ile Gln Gly Val Gly Val Thr Glu Thr Pro Leu Met 
            100                 105                 110         


Lys Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile Thr 
        115                 120                 125             


Leu Tyr Leu Lys Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val Val 
    130                 135                 140                 


Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Thr Asn Leu Gln Glu 
145                 150                 155                 160 


Ser Leu Arg Ser Lys Glu Ile Asp Gly Arg His His His His His His 
                165                 170                 175     


Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp 
            180                 185                 190         


Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly 
        195                 200                 205             


Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu 
    210                 215                 220                 


Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp 
225                 230                 235                 240 


Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg 
                245                 250                 255     


Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser 
            260                 265                 270         


Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu 
        275                 280                 285             


Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser 
    290                 295                 300                 


Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln 
305                 310                 315                 320 


Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala 
                325                 330                 335     


Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys 
            340                 345                 350         


Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala 
        355                 360                 365             


Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly 
    370                 375                 380                 


Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
385                 390                 


<210>  230
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  230
attgatggcc gtcaccacca ccaccaccac ggaaattctc ttgcaaaaaa tgtatta          57


<210>  231
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  231
catttaatta cctcttaacc agttaatg                                          28


<210>  232
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  232
agaggtaatt aaatgctacc ttccggttcg                                        30


<210>  233
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  233
tgcaagagaa tttccacggc catcaatggg ggtgacgatg ccg                         43


<210>  234
<211>  1782
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  234
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgctaccttc cggttcggac      180

cctgcctttt cgcagcccaa gtcggtgctc gatgcgggtc tgacctgcca gggtgcttcg      240

ccatcctcgg tctccaaacc catccttctc gtccccggaa ccggcaccac aggtccacag      300

tcgttcgact cgaactggat ccccctctct gcgcagctgg gttacacacc ctgctggatc      360

tcacccccgc cgttcatgct caacgacacc caggtcaaca cggagtacat ggtcaacgcc      420

atcaccacgc tctacgctgg ttcgggcaac aacaagcttc ccgtgctcac ctggtcccag      480

ggtggtctgg ttgcacagtg gggtctgacc ttcttcccca gtatcaggtc caaggtcgat      540

cgacttatgg cctttgcgcc cgactacaag ggcaccgtcc tcgccggccc tctcgatgca      600

ctcgcggtta gtgcaccctc cgtatggcag caaaccaccg gttcggcact cactaccgca      660

ctccgaaacg caggtggtct gacccagatc gtgcccacca ccaacctcta ctcggcgacc      720

gacgagatcg ttcagcctca ggtgtccaac tcgccactcg actcatccta cctcttcaac      780

ggaaagaacg tccaggcaca ggctgtgtgt gggccgctgt tcgtcatcga ccatgcaggc      840

tcgctcacct cgcagttctc ctacgtcgtc ggtcgatccg ccctgcgctc caccacgggc      900

caggctcgta gtgcagacta tggcattacg gactgcaacc ctcttcccgc caatgatctg      960

actcccgagc aaaaggtcgc cgcggctgcg ctcctggcgc cggcggctgc agccatcgtg     1020

gcgggtccaa agcagaactg cgagcccgac ctcatgccct acgcccgccc ctttgcagta     1080

ggcaaaagga cctgctccgg catcgtcacc cccattgatg gccgtggaaa ttctcttgca     1140

aaaaatgtat tattcggtgg aaaaggtaat gacaagctgt acggcagtga gggggcagat     1200

ctgcttgatg gtggagaggg ggatgatctc ctgaaaggcg gatatggtaa tgatatttat     1260

cgttatctgt caggatatgg tcatcatatt attgatgatg atggggggaa agaggataaa     1320

ctcagtttgg ctgatattga tttccgggat gtggccttca agcgagaagg taatgacctc     1380

atcatgtata aagctgaagg taatgttctt tccattggtc ataaaaatgg tattacattc     1440

aggaactggt ttgaaaaaga gtcaggtgat atctctaatc accagataga gcagattttt     1500

gataaaagtg gccggataat cacacctgat tcccttaaaa aggcacttga gtatcaacag     1560

cgtaataata aggcaagtta tgtgtatggg aatgatgcat tagcctatgg aagtcagggt     1620

gatcttaatc cattaattaa tgaaatcagc aaaatcattt cagctgcagg tagcttcgat     1680

gttaaagagg aaagaactgc agcttcttta ttgcagttgt ccggtaatgc cagtgatttt     1740

tcatatggac ggaactcaat aaccctgacc acatcagcat aa                        1782


<210>  235
<211>  1623
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  235
atgctacctt ccggttcgga ccctgccttt tcgcagccca agtcggtgct cgatgcgggt       60

ctgacctgcc agggtgcttc gccatcctcg gtctccaaac ccatccttct cgtccccgga      120

accggcacca caggtccaca gtcgttcgac tcgaactgga tccccctctc tgcgcagctg      180

ggttacacac cctgctggat ctcacccccg ccgttcatgc tcaacgacac ccaggtcaac      240

acggagtaca tggtcaacgc catcaccacg ctctacgctg gttcgggcaa caacaagctt      300

cccgtgctca cctggtccca gggtggtctg gttgcacagt ggggtctgac cttcttcccc      360

agtatcaggt ccaaggtcga tcgacttatg gcctttgcgc ccgactacaa gggcaccgtc      420

ctcgccggcc ctctcgatgc actcgcggtt agtgcaccct ccgtatggca gcaaaccacc      480

ggttcggcac tcactaccgc actccgaaac gcaggtggtc tgacccagat cgtgcccacc      540

accaacctct actcggcgac cgacgagatc gttcagcctc aggtgtccaa ctcgccactc      600

gactcatcct acctcttcaa cggaaagaac gtccaggcac aggctgtgtg tgggccgctg      660

ttcgtcatcg accatgcagg ctcgctcacc tcgcagttct cctacgtcgt cggtcgatcc      720

gccctgcgct ccaccacggg ccaggctcgt agtgcagact atggcattac ggactgcaac      780

cctcttcccg ccaatgatct gactcccgag caaaaggtcg ccgcggctgc gctcctggcg      840

ccggcggctg cagccatcgt ggcgggtcca aagcagaact gcgagcccga cctcatgccc      900

tacgcccgcc cctttgcagt aggcaaaagg acctgctccg gcatcgtcac ccccattgat      960

ggccgtggaa attctcttgc aaaaaatgta ttattcggtg gaaaaggtaa tgacaagctg     1020

tacggcagtg agggggcaga tctgcttgat ggtggagagg gggatgatct cctgaaaggc     1080

ggatatggta atgatattta tcgttatctg tcaggatatg gtcatcatat tattgatgat     1140

gatgggggga aagaggataa actcagtttg gctgatattg atttccggga tgtggccttc     1200

aagcgagaag gtaatgacct catcatgtat aaagctgaag gtaatgttct ttccattggt     1260

cataaaaatg gtattacatt caggaactgg tttgaaaaag agtcaggtga tatctctaat     1320

caccagatag agcagatttt tgataaaagt ggccggataa tcacacctga ttcccttaaa     1380

aaggcacttg agtatcaaca gcgtaataat aaggcaagtt atgtgtatgg gaatgatgca     1440

ttagcctatg gaagtcaggg tgatcttaat ccattaatta atgaaatcag caaaatcatt     1500

tcagctgcag gtagcttcga tgttaaagag gaaagaactg cagcttcttt attgcagttg     1560

tccggtaatg ccagtgattt ttcatatgga cggaactcaa taaccctgac cacatcagca     1620

taa                                                                   1623


<210>  236
<211>  540
<212>  PRT
<213>  Artificial

<220>
<223>  CalB-HlyA1 fusion

<400>  236

Met Leu Pro Ser Gly Ser Asp Pro Ala Phe Ser Gln Pro Lys Ser Val 
1               5                   10                  15      


Leu Asp Ala Gly Leu Thr Cys Gln Gly Ala Ser Pro Ser Ser Val Ser 
            20                  25                  30          


Lys Pro Ile Leu Leu Val Pro Gly Thr Gly Thr Thr Gly Pro Gln Ser 
        35                  40                  45              


Phe Asp Ser Asn Trp Ile Pro Leu Ser Ala Gln Leu Gly Tyr Thr Pro 
    50                  55                  60                  


Cys Trp Ile Ser Pro Pro Pro Phe Met Leu Asn Asp Thr Gln Val Asn 
65                  70                  75                  80  


Thr Glu Tyr Met Val Asn Ala Ile Thr Thr Leu Tyr Ala Gly Ser Gly 
                85                  90                  95      


Asn Asn Lys Leu Pro Val Leu Thr Trp Ser Gln Gly Gly Leu Val Ala 
            100                 105                 110         


Gln Trp Gly Leu Thr Phe Phe Pro Ser Ile Arg Ser Lys Val Asp Arg 
        115                 120                 125             


Leu Met Ala Phe Ala Pro Asp Tyr Lys Gly Thr Val Leu Ala Gly Pro 
    130                 135                 140                 


Leu Asp Ala Leu Ala Val Ser Ala Pro Ser Val Trp Gln Gln Thr Thr 
145                 150                 155                 160 


Gly Ser Ala Leu Thr Thr Ala Leu Arg Asn Ala Gly Gly Leu Thr Gln 
                165                 170                 175     


Ile Val Pro Thr Thr Asn Leu Tyr Ser Ala Thr Asp Glu Ile Val Gln 
            180                 185                 190         


Pro Gln Val Ser Asn Ser Pro Leu Asp Ser Ser Tyr Leu Phe Asn Gly 
        195                 200                 205             


Lys Asn Val Gln Ala Gln Ala Val Cys Gly Pro Leu Phe Val Ile Asp 
    210                 215                 220                 


His Ala Gly Ser Leu Thr Ser Gln Phe Ser Tyr Val Val Gly Arg Ser 
225                 230                 235                 240 


Ala Leu Arg Ser Thr Thr Gly Gln Ala Arg Ser Ala Asp Tyr Gly Ile 
                245                 250                 255     


Thr Asp Cys Asn Pro Leu Pro Ala Asn Asp Leu Thr Pro Glu Gln Lys 
            260                 265                 270         


Val Ala Ala Ala Ala Leu Leu Ala Pro Ala Ala Ala Ala Ile Val Ala 
        275                 280                 285             


Gly Pro Lys Gln Asn Cys Glu Pro Asp Leu Met Pro Tyr Ala Arg Pro 
    290                 295                 300                 


Phe Ala Val Gly Lys Arg Thr Cys Ser Gly Ile Val Thr Pro Ile Asp 
305                 310                 315                 320 


Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly 
                325                 330                 335     


Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly 
            340                 345                 350         


Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg 
        355                 360                 365             


Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys 
    370                 375                 380                 


Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe 
385                 390                 395                 400 


Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val 
                405                 410                 415     


Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu 
            420                 425                 430         


Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp 
        435                 440                 445             


Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu 
    450                 455                 460                 


Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala 
465                 470                 475                 480 


Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile 
                485                 490                 495     


Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg 
            500                 505                 510         


Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser 
        515                 520                 525             


Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
    530                 535                 540 


<210>  237
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  237
agaggtaatt aaatgagtac aaaagatttt aacttggatt t                           41


<210>  238
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  238
tgcaagagaa tttccacggc catcaatttt gcttacgtga atactacaat gac              53


<210>  239
<211>  999
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  239
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgagtacaaa agattttaac      180

ttggatttgg tatctgtttc gaagaaagat tcaggtgcat caccacgcat tacaagtatt      240

tcgctatgta cacccggttg taaaacagga gctctgatgg gttgtaacat gaaaacagca      300

acttgtcatt gtagtattca cgtaagcaaa attgatggcc gtggaaattc tcttgcaaaa      360

aatgtattat tcggtggaaa aggtaatgac aagctgtacg gcagtgaggg ggcagatctg      420

cttgatggtg gagaggggga tgatctcctg aaaggcggat atggtaatga tatttatcgt      480

tatctgtcag gatatggtca tcatattatt gatgatgatg gggggaaaga ggataaactc      540

agtttggctg atattgattt ccgggatgtg gccttcaagc gagaaggtaa tgacctcatc      600

atgtataaag ctgaaggtaa tgttctttcc attggtcata aaaatggtat tacattcagg      660

aactggtttg aaaaagagtc aggtgatatc tctaatcacc agatagagca gatttttgat      720

aaaagtggcc ggataatcac acctgattcc cttaaaaagg cacttgagta tcaacagcgt      780

aataataagg caagttatgt gtatgggaat gatgcattag cctatggaag tcagggtgat      840

cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtag cttcgatgtt      900

aaagaggaaa gaactgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca      960

tatggacgga actcaataac cctgaccaca tcagcataa                             999


<210>  240
<211>  840
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  240
atgagtacaa aagattttaa cttggatttg gtatctgttt cgaagaaaga ttcaggtgca       60

tcaccacgca ttacaagtat ttcgctatgt acacccggtt gtaaaacagg agctctgatg      120

ggttgtaaca tgaaaacagc aacttgtcat tgtagtattc acgtaagcaa aattgatggc      180

cgtggaaatt ctcttgcaaa aaatgtatta ttcggtggaa aaggtaatga caagctgtac      240

ggcagtgagg gggcagatct gcttgatggt ggagaggggg atgatctcct gaaaggcgga      300

tatggtaatg atatttatcg ttatctgtca ggatatggtc atcatattat tgatgatgat      360

ggggggaaag aggataaact cagtttggct gatattgatt tccgggatgt ggccttcaag      420

cgagaaggta atgacctcat catgtataaa gctgaaggta atgttctttc cattggtcat      480

aaaaatggta ttacattcag gaactggttt gaaaaagagt caggtgatat ctctaatcac      540

cagatagagc agatttttga taaaagtggc cggataatca cacctgattc ccttaaaaag      600

gcacttgagt atcaacagcg taataataag gcaagttatg tgtatgggaa tgatgcatta      660

gcctatggaa gtcagggtga tcttaatcca ttaattaatg aaatcagcaa aatcatttca      720

gctgcaggta gcttcgatgt taaagaggaa agaactgcag cttctttatt gcagttgtcc      780

ggtaatgcca gtgatttttc atatggacgg aactcaataa ccctgaccac atcagcataa      840


<210>  241
<211>  279
<212>  PRT
<213>  Artificial

<220>
<223>  Nisin-HlyA1 fusion

<400>  241

Met Ser Thr Lys Asp Phe Asn Leu Asp Leu Val Ser Val Ser Lys Lys 
1               5                   10                  15      


Asp Ser Gly Ala Ser Pro Arg Ile Thr Ser Ile Ser Leu Cys Thr Pro 
            20                  25                  30          


Gly Cys Lys Thr Gly Ala Leu Met Gly Cys Asn Met Lys Thr Ala Thr 
        35                  40                  45              


Cys His Cys Ser Ile His Val Ser Lys Ile Asp Gly Arg Gly Asn Ser 
    50                  55                  60                  


Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr 
65                  70                  75                  80  


Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu 
                85                  90                  95      


Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr 
            100                 105                 110         


Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser 
        115                 120                 125             


Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn 
    130                 135                 140                 


Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His 
145                 150                 155                 160 


Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp 
                165                 170                 175     


Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile 
            180                 185                 190         


Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn 
        195                 200                 205             


Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser 
    210                 215                 220                 


Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser 
225                 230                 235                 240 


Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu 
                245                 250                 255     


Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser 
            260                 265                 270         


Ile Thr Leu Thr Thr Ser Ala 
        275                 


<210>  242
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  242
agaggtaatt aaatggccga aacacccctg                                        30


<210>  243
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  243
tgcaagagaa tttccacggc catcaatgcg cacgcgctc                              39


<210>  244
<211>  2538
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  244
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggccgaaac acccctgcgc      180

ctggagcgcc tggagcgctg cggcgatctc ctggccagcg agcggcagga gtggtgcctg      240

cgcgtgcgcg gcctgggcgc cggcctgccg cgcctgttgc tggacggccg cgaactgccg      300

gccaccgccc tgcggcgcga gggcgacggc ctgcggctcc gcctggaccg ccgtggccac      360

gccagcggtc cgctttggct ggagcagggc gggcgcagca gcaatccggt atggctgacc      420

ctgaacggca gtcatgtgct cgccgccggt cccgacgagg tggcgaagaa catggatggc      480

ctgaccacct acgtcgacct ggtcagcctg ttgatcgagg agaaccacga cggtcgccgg      540

gaggccgaac gcctggccga taaatatggc gcgcgggtgg tcggcgcgat cccgccgttg      600

aacctctacc agttgcgcct gccggcgcgc gacctcgtcc agcgcgacgc gctggtcctc      660

cgcatcggca gcgagaccag cgtggacgcc gtggtggtgg aggagtccgc gccggagaag      720

ggcgaggaaa ccgaggcggc gcgccggccc gtggacaagc cggacagcga ctccgacgag      780

tgggcggcca atcgtttcat ggacgcggtg aactattacc agcgtcgggt ccgcgcccgc      840

caggcgccgc tggagacccg cccggtgcgc atcggggtga tcgagcgcga cgtcgacttc      900

gacgctcccg acttcgccga ctacctcggc ccctgcaagg cgcccgcacc gcgtacctgc      960

ctctacgcgc gcgatgccga acgtcccgac aaccacggtt cgacggtcgc cggcatcctc     1020

gccgcgcgct gggaccaggg cggcaacagt ggcttcctgc gtgggctgga ccgcgccagc     1080

cagggtttcg aagtgatcgt cgagcgcaat tcggatgctg gcatcacggc caacgtcgcc     1140

gcctcggtga acctggtgga ggatggcgtg cgggtgctca actggagctg gggcatccac     1200

cgcgtcggcg ctcgcgacgt cgatggcgac gaggtggatt cgctggtgcg ctcggggatt     1260

gccatgagcg gctacgagga gttgctcgag gagttcttcc tctggctgcg caaggagcat     1320

ccggacgtgc tggtggtcaa ctccgccggc aacggctcgt cctactccgg taccgacgaa     1380

taccgcctgc cgtcctcctt cgtcaccgag cagttgctgg tggtgggcgg ccaccagcgc     1440

agcgagcgcc aaggcctggc ggtggacgac ccggcctacg cggtcaagcg cagcacctcg     1500

aacgtcgaca tgcgggtgga tgtcaccgcc gccgcctgta cccatgcctc gaccctggag     1560

cgggacgcgc ggggcgaggt gcactgcggc acctcctatg ccacgccgat ggtcgccggc     1620

acggtcgccg ccatgctttc cctcaacccg cggctgcgac ccgaggagat ccgcatgctg     1680

ctccggcgca gcgccatgac catcggcggc gactacgatt tcgagccggc cgatgccgag     1740

gacctcaccg caccgatcct gccctcggag cgcggctacc gcctggacca ccgcgacgtc     1800

ggccgctcgg cgcggctgga catgcagaaa gccctggacc tggcggtgaa gagccgcgag     1860

cgcgtgcgca ttgatggccg tggaaattct cttgcaaaaa atgtattatt cggtggaaaa     1920

ggtaatgaca agctgtacgg cagtgagggg gcagatctgc ttgatggtgg agagggggat     1980

gatctcctga aaggcggata tggtaatgat atttatcgtt atctgtcagg atatggtcat     2040

catattattg atgatgatgg ggggaaagag gataaactca gtttggctga tattgatttc     2100

cgggatgtgg ccttcaagcg agaaggtaat gacctcatca tgtataaagc tgaaggtaat     2160

gttctttcca ttggtcataa aaatggtatt acattcagga actggtttga aaaagagtca     2220

ggtgatatct ctaatcacca gatagagcag atttttgata aaagtggccg gataatcaca     2280

cctgattccc ttaaaaaggc acttgagtat caacagcgta ataataaggc aagttatgtg     2340

tatgggaatg atgcattagc ctatggaagt cagggtgatc ttaatccatt aattaatgaa     2400

atcagcaaaa tcatttcagc tgcaggtagc ttcgatgtta aagaggaaag aactgcagct     2460

tctttattgc agttgtccgg taatgccagt gatttttcat atggacggaa ctcaataacc     2520

ctgaccacat cagcataa                                                   2538


<210>  245
<211>  2379
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  245
atggccgaaa cacccctgcg cctggagcgc ctggagcgct gcggcgatct cctggccagc       60

gagcggcagg agtggtgcct gcgcgtgcgc ggcctgggcg ccggcctgcc gcgcctgttg      120

ctggacggcc gcgaactgcc ggccaccgcc ctgcggcgcg agggcgacgg cctgcggctc      180

cgcctggacc gccgtggcca cgccagcggt ccgctttggc tggagcaggg cgggcgcagc      240

agcaatccgg tatggctgac cctgaacggc agtcatgtgc tcgccgccgg tcccgacgag      300

gtggcgaaga acatggatgg cctgaccacc tacgtcgacc tggtcagcct gttgatcgag      360

gagaaccacg acggtcgccg ggaggccgaa cgcctggccg ataaatatgg cgcgcgggtg      420

gtcggcgcga tcccgccgtt gaacctctac cagttgcgcc tgccggcgcg cgacctcgtc      480

cagcgcgacg cgctggtcct ccgcatcggc agcgagacca gcgtggacgc cgtggtggtg      540

gaggagtccg cgccggagaa gggcgaggaa accgaggcgg cgcgccggcc cgtggacaag      600

ccggacagcg actccgacga gtgggcggcc aatcgtttca tggacgcggt gaactattac      660

cagcgtcggg tccgcgcccg ccaggcgccg ctggagaccc gcccggtgcg catcggggtg      720

atcgagcgcg acgtcgactt cgacgctccc gacttcgccg actacctcgg cccctgcaag      780

gcgcccgcac cgcgtacctg cctctacgcg cgcgatgccg aacgtcccga caaccacggt      840

tcgacggtcg ccggcatcct cgccgcgcgc tgggaccagg gcggcaacag tggcttcctg      900

cgtgggctgg accgcgccag ccagggtttc gaagtgatcg tcgagcgcaa ttcggatgct      960

ggcatcacgg ccaacgtcgc cgcctcggtg aacctggtgg aggatggcgt gcgggtgctc     1020

aactggagct ggggcatcca ccgcgtcggc gctcgcgacg tcgatggcga cgaggtggat     1080

tcgctggtgc gctcggggat tgccatgagc ggctacgagg agttgctcga ggagttcttc     1140

ctctggctgc gcaaggagca tccggacgtg ctggtggtca actccgccgg caacggctcg     1200

tcctactccg gtaccgacga ataccgcctg ccgtcctcct tcgtcaccga gcagttgctg     1260

gtggtgggcg gccaccagcg cagcgagcgc caaggcctgg cggtggacga cccggcctac     1320

gcggtcaagc gcagcacctc gaacgtcgac atgcgggtgg atgtcaccgc cgccgcctgt     1380

acccatgcct cgaccctgga gcgggacgcg cggggcgagg tgcactgcgg cacctcctat     1440

gccacgccga tggtcgccgg cacggtcgcc gccatgcttt ccctcaaccc gcggctgcga     1500

cccgaggaga tccgcatgct gctccggcgc agcgccatga ccatcggcgg cgactacgat     1560

ttcgagccgg ccgatgccga ggacctcacc gcaccgatcc tgccctcgga gcgcggctac     1620

cgcctggacc accgcgacgt cggccgctcg gcgcggctgg acatgcagaa agccctggac     1680

ctggcggtga agagccgcga gcgcgtgcgc attgatggcc gtggaaattc tcttgcaaaa     1740

aatgtattat tcggtggaaa aggtaatgac aagctgtacg gcagtgaggg ggcagatctg     1800

cttgatggtg gagaggggga tgatctcctg aaaggcggat atggtaatga tatttatcgt     1860

tatctgtcag gatatggtca tcatattatt gatgatgatg gggggaaaga ggataaactc     1920

agtttggctg atattgattt ccgggatgtg gccttcaagc gagaaggtaa tgacctcatc     1980

atgtataaag ctgaaggtaa tgttctttcc attggtcata aaaatggtat tacattcagg     2040

aactggtttg aaaaagagtc aggtgatatc tctaatcacc agatagagca gatttttgat     2100

aaaagtggcc ggataatcac acctgattcc cttaaaaagg cacttgagta tcaacagcgt     2160

aataataagg caagttatgt gtatgggaat gatgcattag cctatggaag tcagggtgat     2220

cttaatccat taattaatga aatcagcaaa atcatttcag ctgcaggtag cttcgatgtt     2280

aaagaggaaa gaactgcagc ttctttattg cagttgtccg gtaatgccag tgatttttca     2340

tatggacgga actcaataac cctgaccaca tcagcataa                            2379


<210>  246
<211>  792
<212>  PRT
<213>  Artificial

<220>
<223>  SprP-HlyA1 fusion

<400>  246

Met Ala Glu Thr Pro Leu Arg Leu Glu Arg Leu Glu Arg Cys Gly Asp 
1               5                   10                  15      


Leu Leu Ala Ser Glu Arg Gln Glu Trp Cys Leu Arg Val Arg Gly Leu 
            20                  25                  30          


Gly Ala Gly Leu Pro Arg Leu Leu Leu Asp Gly Arg Glu Leu Pro Ala 
        35                  40                  45              


Thr Ala Leu Arg Arg Glu Gly Asp Gly Leu Arg Leu Arg Leu Asp Arg 
    50                  55                  60                  


Arg Gly His Ala Ser Gly Pro Leu Trp Leu Glu Gln Gly Gly Arg Ser 
65                  70                  75                  80  


Ser Asn Pro Val Trp Leu Thr Leu Asn Gly Ser His Val Leu Ala Ala 
                85                  90                  95      


Gly Pro Asp Glu Val Ala Lys Asn Met Asp Gly Leu Thr Thr Tyr Val 
            100                 105                 110         


Asp Leu Val Ser Leu Leu Ile Glu Glu Asn His Asp Gly Arg Arg Glu 
        115                 120                 125             


Ala Glu Arg Leu Ala Asp Lys Tyr Gly Ala Arg Val Val Gly Ala Ile 
    130                 135                 140                 


Pro Pro Leu Asn Leu Tyr Gln Leu Arg Leu Pro Ala Arg Asp Leu Val 
145                 150                 155                 160 


Gln Arg Asp Ala Leu Val Leu Arg Ile Gly Ser Glu Thr Ser Val Asp 
                165                 170                 175     


Ala Val Val Val Glu Glu Ser Ala Pro Glu Lys Gly Glu Glu Thr Glu 
            180                 185                 190         


Ala Ala Arg Arg Pro Val Asp Lys Pro Asp Ser Asp Ser Asp Glu Trp 
        195                 200                 205             


Ala Ala Asn Arg Phe Met Asp Ala Val Asn Tyr Tyr Gln Arg Arg Val 
    210                 215                 220                 


Arg Ala Arg Gln Ala Pro Leu Glu Thr Arg Pro Val Arg Ile Gly Val 
225                 230                 235                 240 


Ile Glu Arg Asp Val Asp Phe Asp Ala Pro Asp Phe Ala Asp Tyr Leu 
                245                 250                 255     


Gly Pro Cys Lys Ala Pro Ala Pro Arg Thr Cys Leu Tyr Ala Arg Asp 
            260                 265                 270         


Ala Glu Arg Pro Asp Asn His Gly Ser Thr Val Ala Gly Ile Leu Ala 
        275                 280                 285             


Ala Arg Trp Asp Gln Gly Gly Asn Ser Gly Phe Leu Arg Gly Leu Asp 
    290                 295                 300                 


Arg Ala Ser Gln Gly Phe Glu Val Ile Val Glu Arg Asn Ser Asp Ala 
305                 310                 315                 320 


Gly Ile Thr Ala Asn Val Ala Ala Ser Val Asn Leu Val Glu Asp Gly 
                325                 330                 335     


Val Arg Val Leu Asn Trp Ser Trp Gly Ile His Arg Val Gly Ala Arg 
            340                 345                 350         


Asp Val Asp Gly Asp Glu Val Asp Ser Leu Val Arg Ser Gly Ile Ala 
        355                 360                 365             


Met Ser Gly Tyr Glu Glu Leu Leu Glu Glu Phe Phe Leu Trp Leu Arg 
    370                 375                 380                 


Lys Glu His Pro Asp Val Leu Val Val Asn Ser Ala Gly Asn Gly Ser 
385                 390                 395                 400 


Ser Tyr Ser Gly Thr Asp Glu Tyr Arg Leu Pro Ser Ser Phe Val Thr 
                405                 410                 415     


Glu Gln Leu Leu Val Val Gly Gly His Gln Arg Ser Glu Arg Gln Gly 
            420                 425                 430         


Leu Ala Val Asp Asp Pro Ala Tyr Ala Val Lys Arg Ser Thr Ser Asn 
        435                 440                 445             


Val Asp Met Arg Val Asp Val Thr Ala Ala Ala Cys Thr His Ala Ser 
    450                 455                 460                 


Thr Leu Glu Arg Asp Ala Arg Gly Glu Val His Cys Gly Thr Ser Tyr 
465                 470                 475                 480 


Ala Thr Pro Met Val Ala Gly Thr Val Ala Ala Met Leu Ser Leu Asn 
                485                 490                 495     


Pro Arg Leu Arg Pro Glu Glu Ile Arg Met Leu Leu Arg Arg Ser Ala 
            500                 505                 510         


Met Thr Ile Gly Gly Asp Tyr Asp Phe Glu Pro Ala Asp Ala Glu Asp 
        515                 520                 525             


Leu Thr Ala Pro Ile Leu Pro Ser Glu Arg Gly Tyr Arg Leu Asp His 
    530                 535                 540                 


Arg Asp Val Gly Arg Ser Ala Arg Leu Asp Met Gln Lys Ala Leu Asp 
545                 550                 555                 560 


Leu Ala Val Lys Ser Arg Glu Arg Val Arg Ile Asp Gly Arg Gly Asn 
                565                 570                 575     


Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu 
            580                 585                 590         


Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp 
        595                 600                 605             


Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly 
    610                 615                 620                 


Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu 
625                 630                 635                 640 


Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly 
                645                 650                 655     


Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly 
            660                 665                 670         


His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly 
        675                 680                 685             


Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg 
    690                 695                 700                 


Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg 
705                 710                 715                 720 


Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly 
                725                 730                 735     


Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile 
            740                 745                 750         


Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser 
        755                 760                 765             


Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn 
    770                 775                 780                 


Ser Ile Thr Leu Thr Thr Ser Ala 
785                 790         


<210>  247
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  247
ctgtattttc agggcgccga aacacccct                                         29


<210>  248
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  248
tgcaagagaa tttccacggc catcaatgcg cacgcgctc                              39


<210>  249
<211>  2574
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  249
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgcaccacca ccaccaccac      180

gaaaacctgt attttcaggc cgaaacaccc ctgcgcctgg agcgcctgga gcgctgcggc      240

gatctcctgg ccagcgagcg gcaggagtgg tgcctgcgcg tgcgcggcct gggcgccggc      300

ctgccgcgcc tgttgctgga cggccgcgaa ctgccggcca ccgccctgcg gcgcgagggc      360

gacggcctgc ggctccgcct ggaccgccgt ggccacgcca gcggtccgct ttggctggag      420

cagggcgggc gcagcagcaa tccggtatgg ctgaccctga acggcagtca tgtgctcgcc      480

gccggtcccg acgaggtggc gaagaacatg gatggcctga ccacctacgt cgacctggtc      540

agcctgttga tcgaggagaa ccacgacggt cgccgggagg ccgaacgcct ggccgataaa      600

tatggcgcgc gggtggtcgg cgcgatcccg ccgttgaacc tctaccagtt gcgcctgccg      660

gcgcgcgacc tcgtccagcg cgacgcgctg gtcctccgca tcggcagcga gaccagcgtg      720

gacgccgtgg tggtggagga gtccgcgccg gagaagggcg aggaaaccga ggcggcgcgc      780

cggcccgtgg acaagccgga cagcgactcc gacgagtggg cggccaatcg tttcatggac      840

gcggtgaact attaccagcg tcgggtccgc gcccgccagg cgccgctgga gacccgcccg      900

gtgcgcatcg gggtgatcga gcgcgacgtc gacttcgacg ctcccgactt cgccgactac      960

ctcggcccct gcaaggcgcc cgcaccgcgt acctgcctct acgcgcgcga tgccgaacgt     1020

cccgacaacc acggttcgac ggtcgccggc atcctcgccg cgcgctggga ccagggcggc     1080

aacagtggct tcctgcgtgg gctggaccgc gccagccagg gtttcgaagt gatcgtcgag     1140

cgcaattcgg atgctggcat cacggccaac gtcgccgcct cggtgaacct ggtggaggat     1200

ggcgtgcggg tgctcaactg gagctggggc atccaccgcg tcggcgctcg cgacgtcgat     1260

ggcgacgagg tggattcgct ggtgcgctcg gggattgcca tgagcggcta cgaggagttg     1320

ctcgaggagt tcttcctctg gctgcgcaag gagcatccgg acgtgctggt ggtcaactcc     1380

gccggcaacg gctcgtccta ctccggtacc gacgaatacc gcctgccgtc ctccttcgtc     1440

accgagcagt tgctggtggt gggcggccac cagcgcagcg agcgccaagg cctggcggtg     1500

gacgacccgg cctacgcggt caagcgcagc acctcgaacg tcgacatgcg ggtggatgtc     1560

accgccgccg cctgtaccca tgcctcgacc ctggagcggg acgcgcgggg cgaggtgcac     1620

tgcggcacct cctatgccac gccgatggtc gccggcacgg tcgccgccat gctttccctc     1680

aacccgcggc tgcgacccga ggagatccgc atgctgctcc ggcgcagcgc catgaccatc     1740

ggcggcgact acgatttcga gccggccgat gccgaggacc tcaccgcacc gatcctgccc     1800

tcggagcgcg gctaccgcct ggaccaccgc gacgtcggcc gctcggcgcg gctggacatg     1860

cagaaagccc tggacctggc ggtgaagagc cgcgagcgcg tgcgcattga tggccgtgga     1920

aattctcttg caaaaaatgt attattcggt ggaaaaggta atgacaagct gtacggcagt     1980

gagggggcag atctgcttga tggtggagag ggggatgatc tcctgaaagg cggatatggt     2040

aatgatattt atcgttatct gtcaggatat ggtcatcata ttattgatga tgatgggggg     2100

aaagaggata aactcagttt ggctgatatt gatttccggg atgtggcctt caagcgagaa     2160

ggtaatgacc tcatcatgta taaagctgaa ggtaatgttc tttccattgg tcataaaaat     2220

ggtattacat tcaggaactg gtttgaaaaa gagtcaggtg atatctctaa tcaccagata     2280

gagcagattt ttgataaaag tggccggata atcacacctg attcccttaa aaaggcactt     2340

gagtatcaac agcgtaataa taaggcaagt tatgtgtatg ggaatgatgc attagcctat     2400

ggaagtcagg gtgatcttaa tccattaatt aatgaaatca gcaaaatcat ttcagctgca     2460

ggtagcttcg atgttaaaga ggaaagaact gcagcttctt tattgcagtt gtccggtaat     2520

gccagtgatt tttcatatgg acggaactca ataaccctga ccacatcagc ataa           2574


<210>  250
<211>  2415
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  250
atgcaccacc accaccacca cgaaaacctg tattttcagg ccgaaacacc cctgcgcctg       60

gagcgcctgg agcgctgcgg cgatctcctg gccagcgagc ggcaggagtg gtgcctgcgc      120

gtgcgcggcc tgggcgccgg cctgccgcgc ctgttgctgg acggccgcga actgccggcc      180

accgccctgc ggcgcgaggg cgacggcctg cggctccgcc tggaccgccg tggccacgcc      240

agcggtccgc tttggctgga gcagggcggg cgcagcagca atccggtatg gctgaccctg      300

aacggcagtc atgtgctcgc cgccggtccc gacgaggtgg cgaagaacat ggatggcctg      360

accacctacg tcgacctggt cagcctgttg atcgaggaga accacgacgg tcgccgggag      420

gccgaacgcc tggccgataa atatggcgcg cgggtggtcg gcgcgatccc gccgttgaac      480

ctctaccagt tgcgcctgcc ggcgcgcgac ctcgtccagc gcgacgcgct ggtcctccgc      540

atcggcagcg agaccagcgt ggacgccgtg gtggtggagg agtccgcgcc ggagaagggc      600

gaggaaaccg aggcggcgcg ccggcccgtg gacaagccgg acagcgactc cgacgagtgg      660

gcggccaatc gtttcatgga cgcggtgaac tattaccagc gtcgggtccg cgcccgccag      720

gcgccgctgg agacccgccc ggtgcgcatc ggggtgatcg agcgcgacgt cgacttcgac      780

gctcccgact tcgccgacta cctcggcccc tgcaaggcgc ccgcaccgcg tacctgcctc      840

tacgcgcgcg atgccgaacg tcccgacaac cacggttcga cggtcgccgg catcctcgcc      900

gcgcgctggg accagggcgg caacagtggc ttcctgcgtg ggctggaccg cgccagccag      960

ggtttcgaag tgatcgtcga gcgcaattcg gatgctggca tcacggccaa cgtcgccgcc     1020

tcggtgaacc tggtggagga tggcgtgcgg gtgctcaact ggagctgggg catccaccgc     1080

gtcggcgctc gcgacgtcga tggcgacgag gtggattcgc tggtgcgctc ggggattgcc     1140

atgagcggct acgaggagtt gctcgaggag ttcttcctct ggctgcgcaa ggagcatccg     1200

gacgtgctgg tggtcaactc cgccggcaac ggctcgtcct actccggtac cgacgaatac     1260

cgcctgccgt cctccttcgt caccgagcag ttgctggtgg tgggcggcca ccagcgcagc     1320

gagcgccaag gcctggcggt ggacgacccg gcctacgcgg tcaagcgcag cacctcgaac     1380

gtcgacatgc gggtggatgt caccgccgcc gcctgtaccc atgcctcgac cctggagcgg     1440

gacgcgcggg gcgaggtgca ctgcggcacc tcctatgcca cgccgatggt cgccggcacg     1500

gtcgccgcca tgctttccct caacccgcgg ctgcgacccg aggagatccg catgctgctc     1560

cggcgcagcg ccatgaccat cggcggcgac tacgatttcg agccggccga tgccgaggac     1620

ctcaccgcac cgatcctgcc ctcggagcgc ggctaccgcc tggaccaccg cgacgtcggc     1680

cgctcggcgc ggctggacat gcagaaagcc ctggacctgg cggtgaagag ccgcgagcgc     1740

gtgcgcattg atggccgtgg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt     1800

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat     1860

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat     1920

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg     1980

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt     2040

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt     2100

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct     2160

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat     2220

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc     2280

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct     2340

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg     2400

accacatcag cataa                                                      2415


<210>  251
<211>  805
<212>  PRT
<213>  Artificial

<220>
<223>  SprP-HlyA1 fusion

<400>  251

Met His His His His His His Glu Asn Leu Tyr Phe Gln Gly Ala Glu 
1               5                   10                  15      


Thr Pro Leu Arg Leu Glu Arg Leu Glu Arg Cys Gly Asp Leu Leu Ala 
            20                  25                  30          


Ser Glu Arg Gln Glu Trp Cys Leu Arg Val Arg Gly Leu Gly Ala Gly 
        35                  40                  45              


Leu Pro Arg Leu Leu Leu Asp Gly Arg Glu Leu Pro Ala Thr Ala Leu 
    50                  55                  60                  


Arg Arg Glu Gly Asp Gly Leu Arg Leu Arg Leu Asp Arg Arg Gly His 
65                  70                  75                  80  


Ala Ser Gly Pro Leu Trp Leu Glu Gln Gly Gly Arg Ser Ser Asn Pro 
                85                  90                  95      


Val Trp Leu Thr Leu Asn Gly Ser His Val Leu Ala Ala Gly Pro Asp 
            100                 105                 110         


Glu Val Ala Lys Asn Met Asp Gly Leu Thr Thr Tyr Val Asp Leu Val 
        115                 120                 125             


Ser Leu Leu Ile Glu Glu Asn His Asp Gly Arg Arg Glu Ala Glu Arg 
    130                 135                 140                 


Leu Ala Asp Lys Tyr Gly Ala Arg Val Val Gly Ala Ile Pro Pro Leu 
145                 150                 155                 160 


Asn Leu Tyr Gln Leu Arg Leu Pro Ala Arg Asp Leu Val Gln Arg Asp 
                165                 170                 175     


Ala Leu Val Leu Arg Ile Gly Ser Glu Thr Ser Val Asp Ala Val Val 
            180                 185                 190         


Val Glu Glu Ser Ala Pro Glu Lys Gly Glu Glu Thr Glu Ala Ala Arg 
        195                 200                 205             


Arg Pro Val Asp Lys Pro Asp Ser Asp Ser Asp Glu Trp Ala Ala Asn 
    210                 215                 220                 


Arg Phe Met Asp Ala Val Asn Tyr Tyr Gln Arg Arg Val Arg Ala Arg 
225                 230                 235                 240 


Gln Ala Pro Leu Glu Thr Arg Pro Val Arg Ile Gly Val Ile Glu Arg 
                245                 250                 255     


Asp Val Asp Phe Asp Ala Pro Asp Phe Ala Asp Tyr Leu Gly Pro Cys 
            260                 265                 270         


Lys Ala Pro Ala Pro Arg Thr Cys Leu Tyr Ala Arg Asp Ala Glu Arg 
        275                 280                 285             


Pro Asp Asn His Gly Ser Thr Val Ala Gly Ile Leu Ala Ala Arg Trp 
    290                 295                 300                 


Asp Gln Gly Gly Asn Ser Gly Phe Leu Arg Gly Leu Asp Arg Ala Ser 
305                 310                 315                 320 


Gln Gly Phe Glu Val Ile Val Glu Arg Asn Ser Asp Ala Gly Ile Thr 
                325                 330                 335     


Ala Asn Val Ala Ala Ser Val Asn Leu Val Glu Asp Gly Val Arg Val 
            340                 345                 350         


Leu Asn Trp Ser Trp Gly Ile His Arg Val Gly Ala Arg Asp Val Asp 
        355                 360                 365             


Gly Asp Glu Val Asp Ser Leu Val Arg Ser Gly Ile Ala Met Ser Gly 
    370                 375                 380                 


Tyr Glu Glu Leu Leu Glu Glu Phe Phe Leu Trp Leu Arg Lys Glu His 
385                 390                 395                 400 


Pro Asp Val Leu Val Val Asn Ser Ala Gly Asn Gly Ser Ser Tyr Ser 
                405                 410                 415     


Gly Thr Asp Glu Tyr Arg Leu Pro Ser Ser Phe Val Thr Glu Gln Leu 
            420                 425                 430         


Leu Val Val Gly Gly His Gln Arg Ser Glu Arg Gln Gly Leu Ala Val 
        435                 440                 445             


Asp Asp Pro Ala Tyr Ala Val Lys Arg Ser Thr Ser Asn Val Asp Met 
    450                 455                 460                 


Arg Val Asp Val Thr Ala Ala Ala Cys Thr His Ala Ser Thr Leu Glu 
465                 470                 475                 480 


Arg Asp Ala Arg Gly Glu Val His Cys Gly Thr Ser Tyr Ala Thr Pro 
                485                 490                 495     


Met Val Ala Gly Thr Val Ala Ala Met Leu Ser Leu Asn Pro Arg Leu 
            500                 505                 510         


Arg Pro Glu Glu Ile Arg Met Leu Leu Arg Arg Ser Ala Met Thr Ile 
        515                 520                 525             


Gly Gly Asp Tyr Asp Phe Glu Pro Ala Asp Ala Glu Asp Leu Thr Ala 
    530                 535                 540                 


Pro Ile Leu Pro Ser Glu Arg Gly Tyr Arg Leu Asp His Arg Asp Val 
545                 550                 555                 560 


Gly Arg Ser Ala Arg Leu Asp Met Gln Lys Ala Leu Asp Leu Ala Val 
                565                 570                 575     


Lys Ser Arg Glu Arg Val Arg Ile Asp Gly Arg Gly Asn Ser Leu Ala 
            580                 585                 590         


Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser 
        595                 600                 605             


Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys 
    610                 615                 620                 


Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His 
625                 630                 635                 640 


His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala 
                645                 650                 655     


Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu 
            660                 665                 670         


Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn 
        675                 680                 685             


Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser 
    690                 695                 700                 


Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr 
705                 710                 715                 720 


Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys 
                725                 730                 735     


Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly 
            740                 745                 750         


Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala 
        755                 760                 765             


Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln 
    770                 775                 780                 


Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr 
785                 790                 795                 800 


Leu Thr Thr Ser Ala 
                805 


<210>  252
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  252
agaggtaatt aaatggccga aacacccctg                                        30


<210>  253
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  253
gtgacggcca tcaatgcgca cgcgctc                                           27


<210>  254
<211>  2556
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  254
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggccgaaac acccctgcgc      180

ctggagcgcc tggagcgctg cggcgatctc ctggccagcg agcggcagga gtggtgcctg      240

cgcgtgcgcg gcctgggcgc cggcctgccg cgcctgttgc tggacggccg cgaactgccg      300

gccaccgccc tgcggcgcga gggcgacggc ctgcggctcc gcctggaccg ccgtggccac      360

gccagcggtc cgctttggct ggagcagggc gggcgcagca gcaatccggt atggctgacc      420

ctgaacggca gtcatgtgct cgccgccggt cccgacgagg tggcgaagaa catggatggc      480

ctgaccacct acgtcgacct ggtcagcctg ttgatcgagg agaaccacga cggtcgccgg      540

gaggccgaac gcctggccga taaatatggc gcgcgggtgg tcggcgcgat cccgccgttg      600

aacctctacc agttgcgcct gccggcgcgc gacctcgtcc agcgcgacgc gctggtcctc      660

cgcatcggca gcgagaccag cgtggacgcc gtggtggtgg aggagtccgc gccggagaag      720

ggcgaggaaa ccgaggcggc gcgccggccc gtggacaagc cggacagcga ctccgacgag      780

tgggcggcca atcgtttcat ggacgcggtg aactattacc agcgtcgggt ccgcgcccgc      840

caggcgccgc tggagacccg cccggtgcgc atcggggtga tcgagcgcga cgtcgacttc      900

gacgctcccg acttcgccga ctacctcggc ccctgcaagg cgcccgcacc gcgtacctgc      960

ctctacgcgc gcgatgccga acgtcccgac aaccacggtt cgacggtcgc cggcatcctc     1020

gccgcgcgct gggaccaggg cggcaacagt ggcttcctgc gtgggctgga ccgcgccagc     1080

cagggtttcg aagtgatcgt cgagcgcaat tcggatgctg gcatcacggc caacgtcgcc     1140

gcctcggtga acctggtgga ggatggcgtg cgggtgctca actggagctg gggcatccac     1200

cgcgtcggcg ctcgcgacgt cgatggcgac gaggtggatt cgctggtgcg ctcggggatt     1260

gccatgagcg gctacgagga gttgctcgag gagttcttcc tctggctgcg caaggagcat     1320

ccggacgtgc tggtggtcaa ctccgccggc aacggctcgt cctactccgg taccgacgaa     1380

taccgcctgc cgtcctcctt cgtcaccgag cagttgctgg tggtgggcgg ccaccagcgc     1440

agcgagcgcc aaggcctggc ggtggacgac ccggcctacg cggtcaagcg cagcacctcg     1500

aacgtcgaca tgcgggtgga tgtcaccgcc gccgcctgta cccatgcctc gaccctggag     1560

cgggacgcgc ggggcgaggt gcactgcggc acctcctatg ccacgccgat ggtcgccggc     1620

acggtcgccg ccatgctttc cctcaacccg cggctgcgac ccgaggagat ccgcatgctg     1680

ctccggcgca gcgccatgac catcggcggc gactacgatt tcgagccggc cgatgccgag     1740

gacctcaccg caccgatcct gccctcggag cgcggctacc gcctggacca ccgcgacgtc     1800

ggccgctcgg cgcggctgga catgcagaaa gccctggacc tggcggtgaa gagccgcgag     1860

cgcgtgcgca ttgatggccg tcaccaccac caccaccacg gaaattctct tgcaaaaaat     1920

gtattattcg gtggaaaagg taatgacaag ctgtacggca gtgagggggc agatctgctt     1980

gatggtggag agggggatga tctcctgaaa ggcggatatg gtaatgatat ttatcgttat     2040

ctgtcaggat atggtcatca tattattgat gatgatgggg ggaaagagga taaactcagt     2100

ttggctgata ttgatttccg ggatgtggcc ttcaagcgag aaggtaatga cctcatcatg     2160

tataaagctg aaggtaatgt tctttccatt ggtcataaaa atggtattac attcaggaac     2220

tggtttgaaa aagagtcagg tgatatctct aatcaccaga tagagcagat ttttgataaa     2280

agtggccgga taatcacacc tgattccctt aaaaaggcac ttgagtatca acagcgtaat     2340

aataaggcaa gttatgtgta tgggaatgat gcattagcct atggaagtca gggtgatctt     2400

aatccattaa ttaatgaaat cagcaaaatc atttcagctg caggtagctt cgatgttaaa     2460

gaggaaagaa ctgcagcttc tttattgcag ttgtccggta atgccagtga tttttcatat     2520

ggacggaact caataaccct gaccacatca gcataa                               2556


<210>  255
<211>  2397
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  255
atggccgaaa cacccctgcg cctggagcgc ctggagcgct gcggcgatct cctggccagc       60

gagcggcagg agtggtgcct gcgcgtgcgc ggcctgggcg ccggcctgcc gcgcctgttg      120

ctggacggcc gcgaactgcc ggccaccgcc ctgcggcgcg agggcgacgg cctgcggctc      180

cgcctggacc gccgtggcca cgccagcggt ccgctttggc tggagcaggg cgggcgcagc      240

agcaatccgg tatggctgac cctgaacggc agtcatgtgc tcgccgccgg tcccgacgag      300

gtggcgaaga acatggatgg cctgaccacc tacgtcgacc tggtcagcct gttgatcgag      360

gagaaccacg acggtcgccg ggaggccgaa cgcctggccg ataaatatgg cgcgcgggtg      420

gtcggcgcga tcccgccgtt gaacctctac cagttgcgcc tgccggcgcg cgacctcgtc      480

cagcgcgacg cgctggtcct ccgcatcggc agcgagacca gcgtggacgc cgtggtggtg      540

gaggagtccg cgccggagaa gggcgaggaa accgaggcgg cgcgccggcc cgtggacaag      600

ccggacagcg actccgacga gtgggcggcc aatcgtttca tggacgcggt gaactattac      660

cagcgtcggg tccgcgcccg ccaggcgccg ctggagaccc gcccggtgcg catcggggtg      720

atcgagcgcg acgtcgactt cgacgctccc gacttcgccg actacctcgg cccctgcaag      780

gcgcccgcac cgcgtacctg cctctacgcg cgcgatgccg aacgtcccga caaccacggt      840

tcgacggtcg ccggcatcct cgccgcgcgc tgggaccagg gcggcaacag tggcttcctg      900

cgtgggctgg accgcgccag ccagggtttc gaagtgatcg tcgagcgcaa ttcggatgct      960

ggcatcacgg ccaacgtcgc cgcctcggtg aacctggtgg aggatggcgt gcgggtgctc     1020

aactggagct ggggcatcca ccgcgtcggc gctcgcgacg tcgatggcga cgaggtggat     1080

tcgctggtgc gctcggggat tgccatgagc ggctacgagg agttgctcga ggagttcttc     1140

ctctggctgc gcaaggagca tccggacgtg ctggtggtca actccgccgg caacggctcg     1200

tcctactccg gtaccgacga ataccgcctg ccgtcctcct tcgtcaccga gcagttgctg     1260

gtggtgggcg gccaccagcg cagcgagcgc caaggcctgg cggtggacga cccggcctac     1320

gcggtcaagc gcagcacctc gaacgtcgac atgcgggtgg atgtcaccgc cgccgcctgt     1380

acccatgcct cgaccctgga gcgggacgcg cggggcgagg tgcactgcgg cacctcctat     1440

gccacgccga tggtcgccgg cacggtcgcc gccatgcttt ccctcaaccc gcggctgcga     1500

cccgaggaga tccgcatgct gctccggcgc agcgccatga ccatcggcgg cgactacgat     1560

ttcgagccgg ccgatgccga ggacctcacc gcaccgatcc tgccctcgga gcgcggctac     1620

cgcctggacc accgcgacgt cggccgctcg gcgcggctgg acatgcagaa agccctggac     1680

ctggcggtga agagccgcga gcgcgtgcgc attgatggcc gtcaccacca ccaccaccac     1740

ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag gtaatgacaa gctgtacggc     1800

agtgaggggg cagatctgct tgatggtgga gagggggatg atctcctgaa aggcggatat     1860

ggtaatgata tttatcgtta tctgtcagga tatggtcatc atattattga tgatgatggg     1920

gggaaagagg ataaactcag tttggctgat attgatttcc gggatgtggc cttcaagcga     1980

gaaggtaatg acctcatcat gtataaagct gaaggtaatg ttctttccat tggtcataaa     2040

aatggtatta cattcaggaa ctggtttgaa aaagagtcag gtgatatctc taatcaccag     2100

atagagcaga tttttgataa aagtggccgg ataatcacac ctgattccct taaaaaggca     2160

cttgagtatc aacagcgtaa taataaggca agttatgtgt atgggaatga tgcattagcc     2220

tatggaagtc agggtgatct taatccatta attaatgaaa tcagcaaaat catttcagct     2280

gcaggtagct tcgatgttaa agaggaaaga actgcagctt ctttattgca gttgtccggt     2340

aatgccagtg atttttcata tggacggaac tcaataaccc tgaccacatc agcataa        2397


<210>  256
<211>  798
<212>  PRT
<213>  Artificial

<220>
<223>  SprP-HlyA1 fusion

<400>  256

Met Ala Glu Thr Pro Leu Arg Leu Glu Arg Leu Glu Arg Cys Gly Asp 
1               5                   10                  15      


Leu Leu Ala Ser Glu Arg Gln Glu Trp Cys Leu Arg Val Arg Gly Leu 
            20                  25                  30          


Gly Ala Gly Leu Pro Arg Leu Leu Leu Asp Gly Arg Glu Leu Pro Ala 
        35                  40                  45              


Thr Ala Leu Arg Arg Glu Gly Asp Gly Leu Arg Leu Arg Leu Asp Arg 
    50                  55                  60                  


Arg Gly His Ala Ser Gly Pro Leu Trp Leu Glu Gln Gly Gly Arg Ser 
65                  70                  75                  80  


Ser Asn Pro Val Trp Leu Thr Leu Asn Gly Ser His Val Leu Ala Ala 
                85                  90                  95      


Gly Pro Asp Glu Val Ala Lys Asn Met Asp Gly Leu Thr Thr Tyr Val 
            100                 105                 110         


Asp Leu Val Ser Leu Leu Ile Glu Glu Asn His Asp Gly Arg Arg Glu 
        115                 120                 125             


Ala Glu Arg Leu Ala Asp Lys Tyr Gly Ala Arg Val Val Gly Ala Ile 
    130                 135                 140                 


Pro Pro Leu Asn Leu Tyr Gln Leu Arg Leu Pro Ala Arg Asp Leu Val 
145                 150                 155                 160 


Gln Arg Asp Ala Leu Val Leu Arg Ile Gly Ser Glu Thr Ser Val Asp 
                165                 170                 175     


Ala Val Val Val Glu Glu Ser Ala Pro Glu Lys Gly Glu Glu Thr Glu 
            180                 185                 190         


Ala Ala Arg Arg Pro Val Asp Lys Pro Asp Ser Asp Ser Asp Glu Trp 
        195                 200                 205             


Ala Ala Asn Arg Phe Met Asp Ala Val Asn Tyr Tyr Gln Arg Arg Val 
    210                 215                 220                 


Arg Ala Arg Gln Ala Pro Leu Glu Thr Arg Pro Val Arg Ile Gly Val 
225                 230                 235                 240 


Ile Glu Arg Asp Val Asp Phe Asp Ala Pro Asp Phe Ala Asp Tyr Leu 
                245                 250                 255     


Gly Pro Cys Lys Ala Pro Ala Pro Arg Thr Cys Leu Tyr Ala Arg Asp 
            260                 265                 270         


Ala Glu Arg Pro Asp Asn His Gly Ser Thr Val Ala Gly Ile Leu Ala 
        275                 280                 285             


Ala Arg Trp Asp Gln Gly Gly Asn Ser Gly Phe Leu Arg Gly Leu Asp 
    290                 295                 300                 


Arg Ala Ser Gln Gly Phe Glu Val Ile Val Glu Arg Asn Ser Asp Ala 
305                 310                 315                 320 


Gly Ile Thr Ala Asn Val Ala Ala Ser Val Asn Leu Val Glu Asp Gly 
                325                 330                 335     


Val Arg Val Leu Asn Trp Ser Trp Gly Ile His Arg Val Gly Ala Arg 
            340                 345                 350         


Asp Val Asp Gly Asp Glu Val Asp Ser Leu Val Arg Ser Gly Ile Ala 
        355                 360                 365             


Met Ser Gly Tyr Glu Glu Leu Leu Glu Glu Phe Phe Leu Trp Leu Arg 
    370                 375                 380                 


Lys Glu His Pro Asp Val Leu Val Val Asn Ser Ala Gly Asn Gly Ser 
385                 390                 395                 400 


Ser Tyr Ser Gly Thr Asp Glu Tyr Arg Leu Pro Ser Ser Phe Val Thr 
                405                 410                 415     


Glu Gln Leu Leu Val Val Gly Gly His Gln Arg Ser Glu Arg Gln Gly 
            420                 425                 430         


Leu Ala Val Asp Asp Pro Ala Tyr Ala Val Lys Arg Ser Thr Ser Asn 
        435                 440                 445             


Val Asp Met Arg Val Asp Val Thr Ala Ala Ala Cys Thr His Ala Ser 
    450                 455                 460                 


Thr Leu Glu Arg Asp Ala Arg Gly Glu Val His Cys Gly Thr Ser Tyr 
465                 470                 475                 480 


Ala Thr Pro Met Val Ala Gly Thr Val Ala Ala Met Leu Ser Leu Asn 
                485                 490                 495     


Pro Arg Leu Arg Pro Glu Glu Ile Arg Met Leu Leu Arg Arg Ser Ala 
            500                 505                 510         


Met Thr Ile Gly Gly Asp Tyr Asp Phe Glu Pro Ala Asp Ala Glu Asp 
        515                 520                 525             


Leu Thr Ala Pro Ile Leu Pro Ser Glu Arg Gly Tyr Arg Leu Asp His 
    530                 535                 540                 


Arg Asp Val Gly Arg Ser Ala Arg Leu Asp Met Gln Lys Ala Leu Asp 
545                 550                 555                 560 


Leu Ala Val Lys Ser Arg Glu Arg Val Arg Ile Asp Gly Arg His His 
                565                 570                 575     


His His His His Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly 
            580                 585                 590         


Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp 
        595                 600                 605             


Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile 
    610                 615                 620                 


Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly 
625                 630                 635                 640 


Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val 
                645                 650                 655     


Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly 
            660                 665                 670         


Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp 
        675                 680                 685             


Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile 
    690                 695                 700                 


Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala 
705                 710                 715                 720 


Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn 
                725                 730                 735     


Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn 
            740                 745                 750         


Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu 
        755                 760                 765             


Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp 
    770                 775                 780                 


Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
785                 790                 795             


<210>  257
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  257
agaggtaatt aaatggatgg cctgaccac                                         29


<210>  258
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  258
tgcaagagaa tttccacggc catcaatgcg cacgcgctc                              39


<210>  259
<211>  2226
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  259
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggatggcct gaccacctac      180

gtcgacctgg tcagcctgtt gatcgaggag aaccacgacg gtcgccggga ggccgaacgc      240

ctggccgata aatatggcgc gcgggtggtc ggcgcgatcc cgccgttgaa cctctaccag      300

ttgcgcctgc cggcgcgcga cctcgtccag cgcgacgcgc tggtcctccg catcggcagc      360

gagaccagcg tggacgccgt ggtggtggag gagtccgcgc cggagaaggg cgaggaaacc      420

gaggcggcgc gccggcccgt ggacaagccg gacagcgact ccgacgagtg ggcggccaat      480

cgtttcatgg acgcggtgaa ctattaccag cgtcgggtcc gcgcccgcca ggcgccgctg      540

gagacccgcc cggtgcgcat cggggtgatc gagcgcgacg tcgacttcga cgctcccgac      600

ttcgccgact acctcggccc ctgcaaggcg cccgcaccgc gtacctgcct ctacgcgcgc      660

gatgccgaac gtcccgacaa ccacggttcg acggtcgccg gcatcctcgc cgcgcgctgg      720

gaccagggcg gcaacagtgg cttcctgcgt gggctggacc gcgccagcca gggtttcgaa      780

gtgatcgtcg agcgcaattc ggatgctggc atcacggcca acgtcgccgc ctcggtgaac      840

ctggtggagg atggcgtgcg ggtgctcaac tggagctggg gcatccaccg cgtcggcgct      900

cgcgacgtcg atggcgacga ggtggattcg ctggtgcgct cggggattgc catgagcggc      960

tacgaggagt tgctcgagga gttcttcctc tggctgcgca aggagcatcc ggacgtgctg     1020

gtggtcaact ccgccggcaa cggctcgtcc tactccggta ccgacgaata ccgcctgccg     1080

tcctccttcg tcaccgagca gttgctggtg gtgggcggcc accagcgcag cgagcgccaa     1140

ggcctggcgg tggacgaccc ggcctacgcg gtcaagcgca gcacctcgaa cgtcgacatg     1200

cgggtggatg tcaccgccgc cgcctgtacc catgcctcga ccctggagcg ggacgcgcgg     1260

ggcgaggtgc actgcggcac ctcctatgcc acgccgatgg tcgccggcac ggtcgccgcc     1320

atgctttccc tcaacccgcg gctgcgaccc gaggagatcc gcatgctgct ccggcgcagc     1380

gccatgacca tcggcggcga ctacgatttc gagccggccg atgccgagga cctcaccgca     1440

ccgatcctgc cctcggagcg cggctaccgc ctggaccacc gcgacgtcgg ccgctcggcg     1500

cggctggaca tgcagaaagc cctggacctg gcggtgaaga gccgcgagcg cgtgcgcatt     1560

gatggccgtg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag     1620

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa     1680

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat     1740

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc     1800

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt     1860

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct     1920

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt     1980

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat     2040

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc     2100

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag     2160

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca     2220

gcataa                                                                2226


<210>  260
<211>  2226
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  260
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggatggcct gaccacctac      180

gtcgacctgg tcagcctgtt gatcgaggag aaccacgacg gtcgccggga ggccgaacgc      240

ctggccgata aatatggcgc gcgggtggtc ggcgcgatcc cgccgttgaa cctctaccag      300

ttgcgcctgc cggcgcgcga cctcgtccag cgcgacgcgc tggtcctccg catcggcagc      360

gagaccagcg tggacgccgt ggtggtggag gagtccgcgc cggagaaggg cgaggaaacc      420

gaggcggcgc gccggcccgt ggacaagccg gacagcgact ccgacgagtg ggcggccaat      480

cgtttcatgg acgcggtgaa ctattaccag cgtcgggtcc gcgcccgcca ggcgccgctg      540

gagacccgcc cggtgcgcat cggggtgatc gagcgcgacg tcgacttcga cgctcccgac      600

ttcgccgact acctcggccc ctgcaaggcg cccgcaccgc gtacctgcct ctacgcgcgc      660

gatgccgaac gtcccgacaa ccacggttcg acggtcgccg gcatcctcgc cgcgcgctgg      720

gaccagggcg gcaacagtgg cttcctgcgt gggctggacc gcgccagcca gggtttcgaa      780

gtgatcgtcg agcgcaattc ggatgctggc atcacggcca acgtcgccgc ctcggtgaac      840

ctggtggagg atggcgtgcg ggtgctcaac tggagctggg gcatccaccg cgtcggcgct      900

cgcgacgtcg atggcgacga ggtggattcg ctggtgcgct cggggattgc catgagcggc      960

tacgaggagt tgctcgagga gttcttcctc tggctgcgca aggagcatcc ggacgtgctg     1020

gtggtcaact ccgccggcaa cggctcgtcc tactccggta ccgacgaata ccgcctgccg     1080

tcctccttcg tcaccgagca gttgctggtg gtgggcggcc accagcgcag cgagcgccaa     1140

ggcctggcgg tggacgaccc ggcctacgcg gtcaagcgca gcacctcgaa cgtcgacatg     1200

cgggtggatg tcaccgccgc cgcctgtacc catgcctcga ccctggagcg ggacgcgcgg     1260

ggcgaggtgc actgcggcac ctcctatgcc acgccgatgg tcgccggcac ggtcgccgcc     1320

atgctttccc tcaacccgcg gctgcgaccc gaggagatcc gcatgctgct ccggcgcagc     1380

gccatgacca tcggcggcga ctacgatttc gagccggccg atgccgagga cctcaccgca     1440

ccgatcctgc cctcggagcg cggctaccgc ctggaccacc gcgacgtcgg ccgctcggcg     1500

cggctggaca tgcagaaagc cctggacctg gcggtgaaga gccgcgagcg cgtgcgcatt     1560

gatggccgtg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag     1620

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa     1680

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat     1740

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc     1800

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt     1860

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct     1920

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt     1980

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat     2040

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc     2100

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag     2160

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca     2220

gcataa                                                                2226


<210>  261
<211>  688
<212>  PRT
<213>  Artificial

<220>
<223>  SprP-HlyA1 fusion

<400>  261

Met Asp Gly Leu Thr Thr Tyr Val Asp Leu Val Ser Leu Leu Ile Glu 
1               5                   10                  15      


Glu Asn His Asp Gly Arg Arg Glu Ala Glu Arg Leu Ala Asp Lys Tyr 
            20                  25                  30          


Gly Ala Arg Val Val Gly Ala Ile Pro Pro Leu Asn Leu Tyr Gln Leu 
        35                  40                  45              


Arg Leu Pro Ala Arg Asp Leu Val Gln Arg Asp Ala Leu Val Leu Arg 
    50                  55                  60                  


Ile Gly Ser Glu Thr Ser Val Asp Ala Val Val Val Glu Glu Ser Ala 
65                  70                  75                  80  


Pro Glu Lys Gly Glu Glu Thr Glu Ala Ala Arg Arg Pro Val Asp Lys 
                85                  90                  95      


Pro Asp Ser Asp Ser Asp Glu Trp Ala Ala Asn Arg Phe Met Asp Ala 
            100                 105                 110         


Val Asn Tyr Tyr Gln Arg Arg Val Arg Ala Arg Gln Ala Pro Leu Glu 
        115                 120                 125             


Thr Arg Pro Val Arg Ile Gly Val Ile Glu Arg Asp Val Asp Phe Asp 
    130                 135                 140                 


Ala Pro Asp Phe Ala Asp Tyr Leu Gly Pro Cys Lys Ala Pro Ala Pro 
145                 150                 155                 160 


Arg Thr Cys Leu Tyr Ala Arg Asp Ala Glu Arg Pro Asp Asn His Gly 
                165                 170                 175     


Ser Thr Val Ala Gly Ile Leu Ala Ala Arg Trp Asp Gln Gly Gly Asn 
            180                 185                 190         


Ser Gly Phe Leu Arg Gly Leu Asp Arg Ala Ser Gln Gly Phe Glu Val 
        195                 200                 205             


Ile Val Glu Arg Asn Ser Asp Ala Gly Ile Thr Ala Asn Val Ala Ala 
    210                 215                 220                 


Ser Val Asn Leu Val Glu Asp Gly Val Arg Val Leu Asn Trp Ser Trp 
225                 230                 235                 240 


Gly Ile His Arg Val Gly Ala Arg Asp Val Asp Gly Asp Glu Val Asp 
                245                 250                 255     


Ser Leu Val Arg Ser Gly Ile Ala Met Ser Gly Tyr Glu Glu Leu Leu 
            260                 265                 270         


Glu Glu Phe Phe Leu Trp Leu Arg Lys Glu His Pro Asp Val Leu Val 
        275                 280                 285             


Val Asn Ser Ala Gly Asn Gly Ser Ser Tyr Ser Gly Thr Asp Glu Tyr 
    290                 295                 300                 


Arg Leu Pro Ser Ser Phe Val Thr Glu Gln Leu Leu Val Val Gly Gly 
305                 310                 315                 320 


His Gln Arg Ser Glu Arg Gln Gly Leu Ala Val Asp Asp Pro Ala Tyr 
                325                 330                 335     


Ala Val Lys Arg Ser Thr Ser Asn Val Asp Met Arg Val Asp Val Thr 
            340                 345                 350         


Ala Ala Ala Cys Thr His Ala Ser Thr Leu Glu Arg Asp Ala Arg Gly 
        355                 360                 365             


Glu Val His Cys Gly Thr Ser Tyr Ala Thr Pro Met Val Ala Gly Thr 
    370                 375                 380                 


Val Ala Ala Met Leu Ser Leu Asn Pro Arg Leu Arg Pro Glu Glu Ile 
385                 390                 395                 400 


Arg Met Leu Leu Arg Arg Ser Ala Met Thr Ile Gly Gly Asp Tyr Asp 
                405                 410                 415     


Phe Glu Pro Ala Asp Ala Glu Asp Leu Thr Ala Pro Ile Leu Pro Ser 
            420                 425                 430         


Glu Arg Gly Tyr Arg Leu Asp His Arg Asp Val Gly Arg Ser Ala Arg 
        435                 440                 445             


Leu Asp Met Gln Lys Ala Leu Asp Leu Ala Val Lys Ser Arg Glu Arg 
    450                 455                 460                 


Val Arg Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu Phe 
465                 470                 475                 480 


Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu 
                485                 490                 495     


Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn 
            500                 505                 510         


Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp 
        515                 520                 525             


Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg 
    530                 535                 540                 


Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala 
545                 550                 555                 560 


Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg 
                565                 570                 575     


Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu 
            580                 585                 590         


Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys 
        595                 600                 605             


Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr 
    610                 615                 620                 


Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu 
625                 630                 635                 640 


Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val 
                645                 650                 655     


Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala 
            660                 665                 670         


Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
        675                 680                 685             


<210>  262
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  262
agaggtaatt aaatggtgcg catcggg                                           27


<210>  263
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  263
tgcaagagaa tttccacggc catcaatgcg cacgcgctc                              39


<210>  264
<211>  1836
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  264
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggtgcgcat cggggtgatc      180

gagcgcgacg tcgacttcga cgctcccgac ttcgccgact acctcggccc ctgcaaggcg      240

cccgcaccgc gtacctgcct ctacgcgcgc gatgccgaac gtcccgacaa ccacggttcg      300

acggtcgccg gcatcctcgc cgcgcgctgg gaccagggcg gcaacagtgg cttcctgcgt      360

gggctggacc gcgccagcca gggtttcgaa gtgatcgtcg agcgcaattc ggatgctggc      420

atcacggcca acgtcgccgc ctcggtgaac ctggtggagg atggcgtgcg ggtgctcaac      480

tggagctggg gcatccaccg cgtcggcgct cgcgacgtcg atggcgacga ggtggattcg      540

ctggtgcgct cggggattgc catgagcggc tacgaggagt tgctcgagga gttcttcctc      600

tggctgcgca aggagcatcc ggacgtgctg gtggtcaact ccgccggcaa cggctcgtcc      660

tactccggta ccgacgaata ccgcctgccg tcctccttcg tcaccgagca gttgctggtg      720

gtgggcggcc accagcgcag cgagcgccaa ggcctggcgg tggacgaccc ggcctacgcg      780

gtcaagcgca gcacctcgaa cgtcgacatg cgggtggatg tcaccgccgc cgcctgtacc      840

catgcctcga ccctggagcg ggacgcgcgg ggcgaggtgc actgcggcac ctcctatgcc      900

acgccgatgg tcgccggcac ggtcgccgcc atgctttccc tcaacccgcg gctgcgaccc      960

gaggagatcc gcatgctgct ccggcgcagc gccatgacca tcggcggcga ctacgatttc     1020

gagccggccg atgccgagga cctcaccgca ccgatcctgc cctcggagcg cggctaccgc     1080

ctggaccacc gcgacgtcgg ccgctcggcg cggctggaca tgcagaaagc cctggacctg     1140

gcggtgaaga gccgcgagcg cgtgcgcatt gatggccgtg gaaattctct tgcaaaaaat     1200

gtattattcg gtggaaaagg taatgacaag ctgtacggca gtgagggggc agatctgctt     1260

gatggtggag agggggatga tctcctgaaa ggcggatatg gtaatgatat ttatcgttat     1320

ctgtcaggat atggtcatca tattattgat gatgatgggg ggaaagagga taaactcagt     1380

ttggctgata ttgatttccg ggatgtggcc ttcaagcgag aaggtaatga cctcatcatg     1440

tataaagctg aaggtaatgt tctttccatt ggtcataaaa atggtattac attcaggaac     1500

tggtttgaaa aagagtcagg tgatatctct aatcaccaga tagagcagat ttttgataaa     1560

agtggccgga taatcacacc tgattccctt aaaaaggcac ttgagtatca acagcgtaat     1620

aataaggcaa gttatgtgta tgggaatgat gcattagcct atggaagtca gggtgatctt     1680

aatccattaa ttaatgaaat cagcaaaatc atttcagctg caggtagctt cgatgttaaa     1740

gaggaaagaa ctgcagcttc tttattgcag ttgtccggta atgccagtga tttttcatat     1800

ggacggaact caataaccct gaccacatca gcataa                               1836


<210>  265
<211>  1677
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  265
atggtgcgca tcggggtgat cgagcgcgac gtcgacttcg acgctcccga cttcgccgac       60

tacctcggcc cctgcaaggc gcccgcaccg cgtacctgcc tctacgcgcg cgatgccgaa      120

cgtcccgaca accacggttc gacggtcgcc ggcatcctcg ccgcgcgctg ggaccagggc      180

ggcaacagtg gcttcctgcg tgggctggac cgcgccagcc agggtttcga agtgatcgtc      240

gagcgcaatt cggatgctgg catcacggcc aacgtcgccg cctcggtgaa cctggtggag      300

gatggcgtgc gggtgctcaa ctggagctgg ggcatccacc gcgtcggcgc tcgcgacgtc      360

gatggcgacg aggtggattc gctggtgcgc tcggggattg ccatgagcgg ctacgaggag      420

ttgctcgagg agttcttcct ctggctgcgc aaggagcatc cggacgtgct ggtggtcaac      480

tccgccggca acggctcgtc ctactccggt accgacgaat accgcctgcc gtcctccttc      540

gtcaccgagc agttgctggt ggtgggcggc caccagcgca gcgagcgcca aggcctggcg      600

gtggacgacc cggcctacgc ggtcaagcgc agcacctcga acgtcgacat gcgggtggat      660

gtcaccgccg ccgcctgtac ccatgcctcg accctggagc gggacgcgcg gggcgaggtg      720

cactgcggca cctcctatgc cacgccgatg gtcgccggca cggtcgccgc catgctttcc      780

ctcaacccgc ggctgcgacc cgaggagatc cgcatgctgc tccggcgcag cgccatgacc      840

atcggcggcg actacgattt cgagccggcc gatgccgagg acctcaccgc accgatcctg      900

ccctcggagc gcggctaccg cctggaccac cgcgacgtcg gccgctcggc gcggctggac      960

atgcagaaag ccctggacct ggcggtgaag agccgcgagc gcgtgcgcat tgatggccgt     1020

ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag gtaatgacaa gctgtacggc     1080

agtgaggggg cagatctgct tgatggtgga gagggggatg atctcctgaa aggcggatat     1140

ggtaatgata tttatcgtta tctgtcagga tatggtcatc atattattga tgatgatggg     1200

gggaaagagg ataaactcag tttggctgat attgatttcc gggatgtggc cttcaagcga     1260

gaaggtaatg acctcatcat gtataaagct gaaggtaatg ttctttccat tggtcataaa     1320

aatggtatta cattcaggaa ctggtttgaa aaagagtcag gtgatatctc taatcaccag     1380

atagagcaga tttttgataa aagtggccgg ataatcacac ctgattccct taaaaaggca     1440

cttgagtatc aacagcgtaa taataaggca agttatgtgt atgggaatga tgcattagcc     1500

tatggaagtc agggtgatct taatccatta attaatgaaa tcagcaaaat catttcagct     1560

gcaggtagct tcgatgttaa agaggaaaga actgcagctt ctttattgca gttgtccggt     1620

aatgccagtg atttttcata tggacggaac tcaataaccc tgaccacatc agcataa        1677


<210>  266
<211>  558
<212>  PRT
<213>  Artificial

<220>
<223>  SprP-HlyA1 fusion

<400>  266

Met Val Arg Ile Gly Val Ile Glu Arg Asp Val Asp Phe Asp Ala Pro 
1               5                   10                  15      


Asp Phe Ala Asp Tyr Leu Gly Pro Cys Lys Ala Pro Ala Pro Arg Thr 
            20                  25                  30          


Cys Leu Tyr Ala Arg Asp Ala Glu Arg Pro Asp Asn His Gly Ser Thr 
        35                  40                  45              


Val Ala Gly Ile Leu Ala Ala Arg Trp Asp Gln Gly Gly Asn Ser Gly 
    50                  55                  60                  


Phe Leu Arg Gly Leu Asp Arg Ala Ser Gln Gly Phe Glu Val Ile Val 
65                  70                  75                  80  


Glu Arg Asn Ser Asp Ala Gly Ile Thr Ala Asn Val Ala Ala Ser Val 
                85                  90                  95      


Asn Leu Val Glu Asp Gly Val Arg Val Leu Asn Trp Ser Trp Gly Ile 
            100                 105                 110         


His Arg Val Gly Ala Arg Asp Val Asp Gly Asp Glu Val Asp Ser Leu 
        115                 120                 125             


Val Arg Ser Gly Ile Ala Met Ser Gly Tyr Glu Glu Leu Leu Glu Glu 
    130                 135                 140                 


Phe Phe Leu Trp Leu Arg Lys Glu His Pro Asp Val Leu Val Val Asn 
145                 150                 155                 160 


Ser Ala Gly Asn Gly Ser Ser Tyr Ser Gly Thr Asp Glu Tyr Arg Leu 
                165                 170                 175     


Pro Ser Ser Phe Val Thr Glu Gln Leu Leu Val Val Gly Gly His Gln 
            180                 185                 190         


Arg Ser Glu Arg Gln Gly Leu Ala Val Asp Asp Pro Ala Tyr Ala Val 
        195                 200                 205             


Lys Arg Ser Thr Ser Asn Val Asp Met Arg Val Asp Val Thr Ala Ala 
    210                 215                 220                 


Ala Cys Thr His Ala Ser Thr Leu Glu Arg Asp Ala Arg Gly Glu Val 
225                 230                 235                 240 


His Cys Gly Thr Ser Tyr Ala Thr Pro Met Val Ala Gly Thr Val Ala 
                245                 250                 255     


Ala Met Leu Ser Leu Asn Pro Arg Leu Arg Pro Glu Glu Ile Arg Met 
            260                 265                 270         


Leu Leu Arg Arg Ser Ala Met Thr Ile Gly Gly Asp Tyr Asp Phe Glu 
        275                 280                 285             


Pro Ala Asp Ala Glu Asp Leu Thr Ala Pro Ile Leu Pro Ser Glu Arg 
    290                 295                 300                 


Gly Tyr Arg Leu Asp His Arg Asp Val Gly Arg Ser Ala Arg Leu Asp 
305                 310                 315                 320 


Met Gln Lys Ala Leu Asp Leu Ala Val Lys Ser Arg Glu Arg Val Arg 
                325                 330                 335     


Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly 
            340                 345                 350         


Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp 
        355                 360                 365             


Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile 
    370                 375                 380                 


Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly 
385                 390                 395                 400 


Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val 
                405                 410                 415     


Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly 
            420                 425                 430         


Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp 
        435                 440                 445             


Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile 
    450                 455                 460                 


Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala 
465                 470                 475                 480 


Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn 
                485                 490                 495     


Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn 
            500                 505                 510         


Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu 
        515                 520                 525             


Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp 
    530                 535                 540                 


Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
545                 550                 555             


<210>  267
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  267
agaggtaatt aaatgccccg ttcgatcgt                                         29


<210>  268
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  268
tgcaagagaa tttccacggc catcaatggg gttcctgaag acgaatac                    48


<210>  269
<211>  2157
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  269
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgccccgttc gatcgtcatc      180

gtccacggct ggagcgacga ttcgaagtcg ttccgccgcc tcgccgagca gttggaagcc      240

tggttcggca gcgcgccgac gcagatccgc ctcaccgact ggatctccct gcaggacgac      300

gtcacctacg ccgacctcgc cgccgccctg gatcgcgcct ggaccgccca gggactgtcg      360

cgggcaccgc gcacggttga cgtggtggtg cacagcaccg gcaccctggt gctgcgcgac      420

tggctgaccc gccacttcga ccccgccagc gcgccggtca agcgcttcct gatgctcgcc      480

ccggccaact tcggctcgcc gctggcgcac aagggacgct ccttcatcgg tcgcgtgctg      540

aaaggctgga accgcttcgt cgggcagacc ggcacccagg tgctgaaggg actggagctg      600

ggctcgccgt actcctggca actcgccgag cgcgacctgt tcggcgccga ggcctggtac      660

ggcgccgacc gcctgctcgc cacggtgctg gtgggcaatg tcggctacag cggcgtcgaa      720

gccatcgcca acgaggccgg cagcgacggc actgtgcgga tcgccacggc gaacctcaac      780

gcctgccgcc tgagcctcga actggatgtc cgccagcgcg ccaggcccgg ctggcgcctg      840

gaagaatcgc gcggcgagat cgccttcgcc atcgtcgacg gcgagaacca cgccagcgtg      900

gcgctgaagg accgcggacc gaagaacccg cataccctgg agctgatccg cgccgcactg      960

gaggtcgagg acgccgatta ccggagcagc ggcgcaagct tcccctggca gcgccgcatc     1020

gatcagctcg accccggcat cgagcgccgc tcgccgcgct acctgaacct ggtcagccac     1080

gtctgcgacg acctcgacca ggaggtgcgc gactacttca tccagttctt ccgcaagctg     1140

aacagcgacc ggcgtttcga gcagcgcttc tacgagcagg tcatcgccga cgtccatccc     1200

tacgaggaca accccgccta ccgctcgctg tacctgtcga tcgagtccct cgacgacctg     1260

ctcgccggct tcgccgtgga caccctgtcg ctcagcgtgt cggcccagcc gccgttcgat     1320

ccgccgcgcc agccggtcgg ctataccgcg gtgggccccg gcgacagcga aggcctggca     1380

attccgctgg cgcaggtgcc gcgcttcctc gcagcccacc gcaccctgct gctgcgcatc     1440

cgcctgacgc gcctggtgga cagcggcgta ttcgtcttca ggaaccccat tgatggccgt     1500

ggaaattctc ttgcaaaaaa tgtattattc ggtggaaaag gtaatgacaa gctgtacggc     1560

agtgaggggg cagatctgct tgatggtgga gagggggatg atctcctgaa aggcggatat     1620

ggtaatgata tttatcgtta tctgtcagga tatggtcatc atattattga tgatgatggg     1680

gggaaagagg ataaactcag tttggctgat attgatttcc gggatgtggc cttcaagcga     1740

gaaggtaatg acctcatcat gtataaagct gaaggtaatg ttctttccat tggtcataaa     1800

aatggtatta cattcaggaa ctggtttgaa aaagagtcag gtgatatctc taatcaccag     1860

atagagcaga tttttgataa aagtggccgg ataatcacac ctgattccct taaaaaggca     1920

cttgagtatc aacagcgtaa taataaggca agttatgtgt atgggaatga tgcattagcc     1980

tatggaagtc agggtgatct taatccatta attaatgaaa tcagcaaaat catttcagct     2040

gcaggtagct tcgatgttaa agaggaaaga actgcagctt ctttattgca gttgtccggt     2100

aatgccagtg atttttcata tggacggaac tcaataaccc tgaccacatc agcataa        2157


<210>  270
<211>  1998
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  270
atgccccgtt cgatcgtcat cgtccacggc tggagcgacg attcgaagtc gttccgccgc       60

ctcgccgagc agttggaagc ctggttcggc agcgcgccga cgcagatccg cctcaccgac      120

tggatctccc tgcaggacga cgtcacctac gccgacctcg ccgccgccct ggatcgcgcc      180

tggaccgccc agggactgtc gcgggcaccg cgcacggttg acgtggtggt gcacagcacc      240

ggcaccctgg tgctgcgcga ctggctgacc cgccacttcg accccgccag cgcgccggtc      300

aagcgcttcc tgatgctcgc cccggccaac ttcggctcgc cgctggcgca caagggacgc      360

tccttcatcg gtcgcgtgct gaaaggctgg aaccgcttcg tcgggcagac cggcacccag      420

gtgctgaagg gactggagct gggctcgccg tactcctggc aactcgccga gcgcgacctg      480

ttcggcgccg aggcctggta cggcgccgac cgcctgctcg ccacggtgct ggtgggcaat      540

gtcggctaca gcggcgtcga agccatcgcc aacgaggccg gcagcgacgg cactgtgcgg      600

atcgccacgg cgaacctcaa cgcctgccgc ctgagcctcg aactggatgt ccgccagcgc      660

gccaggcccg gctggcgcct ggaagaatcg cgcggcgaga tcgccttcgc catcgtcgac      720

ggcgagaacc acgccagcgt ggcgctgaag gaccgcggac cgaagaaccc gcataccctg      780

gagctgatcc gcgccgcact ggaggtcgag gacgccgatt accggagcag cggcgcaagc      840

ttcccctggc agcgccgcat cgatcagctc gaccccggca tcgagcgccg ctcgccgcgc      900

tacctgaacc tggtcagcca cgtctgcgac gacctcgacc aggaggtgcg cgactacttc      960

atccagttct tccgcaagct gaacagcgac cggcgtttcg agcagcgctt ctacgagcag     1020

gtcatcgccg acgtccatcc ctacgaggac aaccccgcct accgctcgct gtacctgtcg     1080

atcgagtccc tcgacgacct gctcgccggc ttcgccgtgg acaccctgtc gctcagcgtg     1140

tcggcccagc cgccgttcga tccgccgcgc cagccggtcg gctataccgc ggtgggcccc     1200

ggcgacagcg aaggcctggc aattccgctg gcgcaggtgc cgcgcttcct cgcagcccac     1260

cgcaccctgc tgctgcgcat ccgcctgacg cgcctggtgg acagcggcgt attcgtcttc     1320

aggaacccca ttgatggccg tggaaattct cttgcaaaaa atgtattatt cggtggaaaa     1380

ggtaatgaca agctgtacgg cagtgagggg gcagatctgc ttgatggtgg agagggggat     1440

gatctcctga aaggcggata tggtaatgat atttatcgtt atctgtcagg atatggtcat     1500

catattattg atgatgatgg ggggaaagag gataaactca gtttggctga tattgatttc     1560

cgggatgtgg ccttcaagcg agaaggtaat gacctcatca tgtataaagc tgaaggtaat     1620

gttctttcca ttggtcataa aaatggtatt acattcagga actggtttga aaaagagtca     1680

ggtgatatct ctaatcacca gatagagcag atttttgata aaagtggccg gataatcaca     1740

cctgattccc ttaaaaaggc acttgagtat caacagcgta ataataaggc aagttatgtg     1800

tatgggaatg atgcattagc ctatggaagt cagggtgatc ttaatccatt aattaatgaa     1860

atcagcaaaa tcatttcagc tgcaggtagc ttcgatgtta aagaggaaag aactgcagct     1920

tctttattgc agttgtccgg taatgccagt gatttttcat atggacggaa ctcaataacc     1980

ctgaccacat cagcataa                                                   1998


<210>  271
<211>  665
<212>  PRT
<213>  Artificial

<220>
<223>  PlaB-HlyA1 fusion

<400>  271

Met Pro Arg Ser Ile Val Ile Val His Gly Trp Ser Asp Asp Ser Lys 
1               5                   10                  15      


Ser Phe Arg Arg Leu Ala Glu Gln Leu Glu Ala Trp Phe Gly Ser Ala 
            20                  25                  30          


Pro Thr Gln Ile Arg Leu Thr Asp Trp Ile Ser Leu Gln Asp Asp Val 
        35                  40                  45              


Thr Tyr Ala Asp Leu Ala Ala Ala Leu Asp Arg Ala Trp Thr Ala Gln 
    50                  55                  60                  


Gly Leu Ser Arg Ala Pro Arg Thr Val Asp Val Val Val His Ser Thr 
65                  70                  75                  80  


Gly Thr Leu Val Leu Arg Asp Trp Leu Thr Arg His Phe Asp Pro Ala 
                85                  90                  95      


Ser Ala Pro Val Lys Arg Phe Leu Met Leu Ala Pro Ala Asn Phe Gly 
            100                 105                 110         


Ser Pro Leu Ala His Lys Gly Arg Ser Phe Ile Gly Arg Val Leu Lys 
        115                 120                 125             


Gly Trp Asn Arg Phe Val Gly Gln Thr Gly Thr Gln Val Leu Lys Gly 
    130                 135                 140                 


Leu Glu Leu Gly Ser Pro Tyr Ser Trp Gln Leu Ala Glu Arg Asp Leu 
145                 150                 155                 160 


Phe Gly Ala Glu Ala Trp Tyr Gly Ala Asp Arg Leu Leu Ala Thr Val 
                165                 170                 175     


Leu Val Gly Asn Val Gly Tyr Ser Gly Val Glu Ala Ile Ala Asn Glu 
            180                 185                 190         


Ala Gly Ser Asp Gly Thr Val Arg Ile Ala Thr Ala Asn Leu Asn Ala 
        195                 200                 205             


Cys Arg Leu Ser Leu Glu Leu Asp Val Arg Gln Arg Ala Arg Pro Gly 
    210                 215                 220                 


Trp Arg Leu Glu Glu Ser Arg Gly Glu Ile Ala Phe Ala Ile Val Asp 
225                 230                 235                 240 


Gly Glu Asn His Ala Ser Val Ala Leu Lys Asp Arg Gly Pro Lys Asn 
                245                 250                 255     


Pro His Thr Leu Glu Leu Ile Arg Ala Ala Leu Glu Val Glu Asp Ala 
            260                 265                 270         


Asp Tyr Arg Ser Ser Gly Ala Ser Phe Pro Trp Gln Arg Arg Ile Asp 
        275                 280                 285             


Gln Leu Asp Pro Gly Ile Glu Arg Arg Ser Pro Arg Tyr Leu Asn Leu 
    290                 295                 300                 


Val Ser His Val Cys Asp Asp Leu Asp Gln Glu Val Arg Asp Tyr Phe 
305                 310                 315                 320 


Ile Gln Phe Phe Arg Lys Leu Asn Ser Asp Arg Arg Phe Glu Gln Arg 
                325                 330                 335     


Phe Tyr Glu Gln Val Ile Ala Asp Val His Pro Tyr Glu Asp Asn Pro 
            340                 345                 350         


Ala Tyr Arg Ser Leu Tyr Leu Ser Ile Glu Ser Leu Asp Asp Leu Leu 
        355                 360                 365             


Ala Gly Phe Ala Val Asp Thr Leu Ser Leu Ser Val Ser Ala Gln Pro 
    370                 375                 380                 


Pro Phe Asp Pro Pro Arg Gln Pro Val Gly Tyr Thr Ala Val Gly Pro 
385                 390                 395                 400 


Gly Asp Ser Glu Gly Leu Ala Ile Pro Leu Ala Gln Val Pro Arg Phe 
                405                 410                 415     


Leu Ala Ala His Arg Thr Leu Leu Leu Arg Ile Arg Leu Thr Arg Leu 
            420                 425                 430         


Val Asp Ser Gly Val Phe Val Phe Arg Asn Pro Ile Asp Gly Arg Gly 
        435                 440                 445             


Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys 
    450                 455                 460                 


Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp 
465                 470                 475                 480 


Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser 
                485                 490                 495     


Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys 
            500                 505                 510         


Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu 
        515                 520                 525             


Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile 
    530                 535                 540                 


Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser 
545                 550                 555                 560 


Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly 
                565                 570                 575     


Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln 
            580                 585                 590         


Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr 
        595                 600                 605             


Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile 
    610                 615                 620                 


Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala 
625                 630                 635                 640 


Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg 
                645                 650                 655     


Asn Ser Ile Thr Leu Thr Thr Ser Ala 
            660                 665 


<210>  272
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  272
agaggtaatt aaatgccccg accactttcc                                        30


<210>  273
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  273
tgcaagagaa tttccacggc catcaatcag acactccccc gcg                         43


<210>  274
<211>  2004
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  274
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgccccgacc actttcccac      180

cggaacttgc ccatgacgcc ccaaggccac tgtgacagcc gtttcgcccc gcttgccgag      240

gccttcgccc ggcttttcga caatccgcag gagcgcggcg cggcgttgtg cctggaggtc      300

ggtggcgaga cggtggtcga cctctggggc ggcgtcgcgg acaaggacgg cgagcagccc      360

tggcagcgcg acaccatcct caatctgttc tcctgcacca agaccttcac cgccgttgcc      420

gtgctgcaac tggtggccga gggcaagctc gaactggacg cgccggtggc acactactgg      480

cccgagttcg ccgcggccgg caaggcagcg atcagcgtgc gccagttgct ctgccatcgc      540

gccggcctgc cggcgctgcg cgagcagatg ccgcccgagg cactctacga ctggcaggcg      600

atgaccacgg cactggccgc cgaggagccc tggtggacgc ctggcgaagc gcacggctat      660

gcaccgatta cctatggctg gctgctcggc gaggtgatcc gccgggtcga cggccgcgag      720

ccgggcgagg ccatcgtggc gcgcaccgcg gcaccgctgg gcctggattt ccatgtcggc      780

ctggacgaca gccagttcgg ccgcgtcgcc cacatggcac ggagcaaggg cagcctcggc      840

gacgctgccg cccagcgcat gctgaagacc atgatgagcg agccattggc gctgaccacc      900

cgtgccttca ccaatccgcc gtcgatcctc accagcacca acaagccgga atggcgacgc      960

atgcagcagc cggccgccaa tggccatggc aacgcgcgcg cgctcgccgg cttctatagc     1020

ggcctgttgc agggacgttt gctggaagat gaactgctgg gccagttggc ccacgaacac     1080

gcggtaggcg aggatcggac cttgctgacc cggacccgct tcggcctcgg caccatgctc     1140

gaccaaccgg gcgtggccaa tgcgacctac ggactcggcc ccaaggcctt cggccaccct     1200

ggggcgggtg gctcgatcgg cttcgccgat cccgagcgcg acctggcttt ttcctttgtc     1260

agcaacgcct tggggccgta tgtgctgatg gatccgcggg cgcagcagct ggcgcgtgtc     1320

gcgggggagt gtctgattga tggccgtgga aattctcttg caaaaaatgt attattcggt     1380

ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga tggtggagag     1440

ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct gtcaggatat     1500

ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt ggctgatatt     1560

gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta taaagctgaa     1620

ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg gtttgaaaaa     1680

gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag tggccggata     1740

atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa taaggcaagt     1800

tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa tccattaatt     1860

aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga ggaaagaact     1920

gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg acggaactca     1980

ataaccctga ccacatcagc ataa                                            2004


<210>  275
<211>  1845
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  275
atgccccgac cactttccca ccggaacttg cccatgacgc cccaaggcca ctgtgacagc       60

cgtttcgccc cgcttgccga ggccttcgcc cggcttttcg acaatccgca ggagcgcggc      120

gcggcgttgt gcctggaggt cggtggcgag acggtggtcg acctctgggg cggcgtcgcg      180

gacaaggacg gcgagcagcc ctggcagcgc gacaccatcc tcaatctgtt ctcctgcacc      240

aagaccttca ccgccgttgc cgtgctgcaa ctggtggccg agggcaagct cgaactggac      300

gcgccggtgg cacactactg gcccgagttc gccgcggccg gcaaggcagc gatcagcgtg      360

cgccagttgc tctgccatcg cgccggcctg ccggcgctgc gcgagcagat gccgcccgag      420

gcactctacg actggcaggc gatgaccacg gcactggccg ccgaggagcc ctggtggacg      480

cctggcgaag cgcacggcta tgcaccgatt acctatggct ggctgctcgg cgaggtgatc      540

cgccgggtcg acggccgcga gccgggcgag gccatcgtgg cgcgcaccgc ggcaccgctg      600

ggcctggatt tccatgtcgg cctggacgac agccagttcg gccgcgtcgc ccacatggca      660

cggagcaagg gcagcctcgg cgacgctgcc gcccagcgca tgctgaagac catgatgagc      720

gagccattgg cgctgaccac ccgtgccttc accaatccgc cgtcgatcct caccagcacc      780

aacaagccgg aatggcgacg catgcagcag ccggccgcca atggccatgg caacgcgcgc      840

gcgctcgccg gcttctatag cggcctgttg cagggacgtt tgctggaaga tgaactgctg      900

ggccagttgg cccacgaaca cgcggtaggc gaggatcgga ccttgctgac ccggacccgc      960

ttcggcctcg gcaccatgct cgaccaaccg ggcgtggcca atgcgaccta cggactcggc     1020

cccaaggcct tcggccaccc tggggcgggt ggctcgatcg gcttcgccga tcccgagcgc     1080

gacctggctt tttcctttgt cagcaacgcc ttggggccgt atgtgctgat ggatccgcgg     1140

gcgcagcagc tggcgcgtgt cgcgggggag tgtctgattg atggccgtgg aaattctctt     1200

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca     1260

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt     1320

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat     1380

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac     1440

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca     1500

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt     1560

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa     1620

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag     1680

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc     1740

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1800

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1845


<210>  276
<211>  614
<212>  PRT
<213>  Artificial

<220>
<223>  PlaK-HlyA1 fusion

<400>  276

Met Pro Arg Pro Leu Ser His Arg Asn Leu Pro Met Thr Pro Gln Gly 
1               5                   10                  15      


His Cys Asp Ser Arg Phe Ala Pro Leu Ala Glu Ala Phe Ala Arg Leu 
            20                  25                  30          


Phe Asp Asn Pro Gln Glu Arg Gly Ala Ala Leu Cys Leu Glu Val Gly 
        35                  40                  45              


Gly Glu Thr Val Val Asp Leu Trp Gly Gly Val Ala Asp Lys Asp Gly 
    50                  55                  60                  


Glu Gln Pro Trp Gln Arg Asp Thr Ile Leu Asn Leu Phe Ser Cys Thr 
65                  70                  75                  80  


Lys Thr Phe Thr Ala Val Ala Val Leu Gln Leu Val Ala Glu Gly Lys 
                85                  90                  95      


Leu Glu Leu Asp Ala Pro Val Ala His Tyr Trp Pro Glu Phe Ala Ala 
            100                 105                 110         


Ala Gly Lys Ala Ala Ile Ser Val Arg Gln Leu Leu Cys His Arg Ala 
        115                 120                 125             


Gly Leu Pro Ala Leu Arg Glu Gln Met Pro Pro Glu Ala Leu Tyr Asp 
    130                 135                 140                 


Trp Gln Ala Met Thr Thr Ala Leu Ala Ala Glu Glu Pro Trp Trp Thr 
145                 150                 155                 160 


Pro Gly Glu Ala His Gly Tyr Ala Pro Ile Thr Tyr Gly Trp Leu Leu 
                165                 170                 175     


Gly Glu Val Ile Arg Arg Val Asp Gly Arg Glu Pro Gly Glu Ala Ile 
            180                 185                 190         


Val Ala Arg Thr Ala Ala Pro Leu Gly Leu Asp Phe His Val Gly Leu 
        195                 200                 205             


Asp Asp Ser Gln Phe Gly Arg Val Ala His Met Ala Arg Ser Lys Gly 
    210                 215                 220                 


Ser Leu Gly Asp Ala Ala Ala Gln Arg Met Leu Lys Thr Met Met Ser 
225                 230                 235                 240 


Glu Pro Leu Ala Leu Thr Thr Arg Ala Phe Thr Asn Pro Pro Ser Ile 
                245                 250                 255     


Leu Thr Ser Thr Asn Lys Pro Glu Trp Arg Arg Met Gln Gln Pro Ala 
            260                 265                 270         


Ala Asn Gly His Gly Asn Ala Arg Ala Leu Ala Gly Phe Tyr Ser Gly 
        275                 280                 285             


Leu Leu Gln Gly Arg Leu Leu Glu Asp Glu Leu Leu Gly Gln Leu Ala 
    290                 295                 300                 


His Glu His Ala Val Gly Glu Asp Arg Thr Leu Leu Thr Arg Thr Arg 
305                 310                 315                 320 


Phe Gly Leu Gly Thr Met Leu Asp Gln Pro Gly Val Ala Asn Ala Thr 
                325                 330                 335     


Tyr Gly Leu Gly Pro Lys Ala Phe Gly His Pro Gly Ala Gly Gly Ser 
            340                 345                 350         


Ile Gly Phe Ala Asp Pro Glu Arg Asp Leu Ala Phe Ser Phe Val Ser 
        355                 360                 365             


Asn Ala Leu Gly Pro Tyr Val Leu Met Asp Pro Arg Ala Gln Gln Leu 
    370                 375                 380                 


Ala Arg Val Ala Gly Glu Cys Leu Ile Asp Gly Arg Gly Asn Ser Leu 
385                 390                 395                 400 


Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly 
                405                 410                 415     


Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu 
            420                 425                 430         


Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly 
        435                 440                 445             


His His Ile Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu 
    450                 455                 460                 


Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp 
465                 470                 475                 480 


Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys 
                485                 490                 495     


Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile 
            500                 505                 510         


Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile 
        515                 520                 525             


Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn 
    530                 535                 540                 


Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln 
545                 550                 555                 560 


Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala 
                565                 570                 575     


Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu 
            580                 585                 590         


Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile 
        595                 600                 605             


Thr Leu Thr Thr Ser Ala 
    610                 


<210>  277
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  277
agaggtaatt aaatgagcgt acgcaccgtc                                        30


<210>  278
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  278
tgcaagagaa tttccacggc catcaatgcg accggccacc                             40


<210>  279
<211>  1692
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  279
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgagcgtacg caccgtcgag      180

cgcggtctcg ccggtctcag cgagcacagc gtgcaggtcg acaacctgga gatcgcctac      240

ctggaaggtg gctcggagaa gaacccgacc ctgttgctga tccacggctt cggcgccgac      300

aaggacaact ggctgcgctt cgcccggccg ctgaccgagc gctaccatgt ggtcgccctc      360

gacctgcccg gcttcggcga cagcagcaag ccgcaacagg ccagctacga cgtcggcacc      420

caggccgagc gagtcgccaa tttcgccgcc gccatcggcg tgcgccgcct gcacctggcc      480

ggcaactcca tgggcgggca catcgccgcg ctctacgcgg cgcgccatcc ggaacaggtg      540

ctatcgctgg cgctgatcga caacgccggg gtgatgccgg cgcgcaagag cgaactgttc      600

gaggacctgg agcgcggcga gaatcccctg gtggtgcgcc agccggaaga cttccagaag      660

ctgctcgact tcgtgttcgt ccagcaaccg ccgctgccgg cgccgctcaa gcgctacctc      720

ggcgagcgcg cggtagccgc gtcggcgttc aacgcgcaga tattcgaaca actgcgccag      780

cgctacatcc cgctggagcc ggaactgccg aagatcgagg caccgaccct gctgctgtgg      840

ggcgaccgcg accgcgtgct ggacgtctcc agcatcgagg tgatgcgtcc gctgctgaag      900

cggcccagcg tggtgatcat ggaaaactgc ggacacgtgc cgatggtcga acgcccggag      960

gaaaccgcgc agcactacca ggccttcctc gacggcgtac ggaacgccca ggtggccggt     1020

cgcattgatg gccgtggaaa ttctcttgca aaaaatgtat tattcggtgg aaaaggtaat     1080

gacaagctgt acggcagtga gggggcagat ctgcttgatg gtggagaggg ggatgatctc     1140

ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg tcatcatatt     1200

attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat     1260

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt     1320

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat     1380

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat     1440

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg     1500

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc     1560

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta     1620

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc     1680

acatcagcat aa                                                         1692


<210>  280
<211>  1533
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  280
atgagcgtac gcaccgtcga gcgcggtctc gccggtctca gcgagcacag cgtgcaggtc       60

gacaacctgg agatcgccta cctggaaggt ggctcggaga agaacccgac cctgttgctg      120

atccacggct tcggcgccga caaggacaac tggctgcgct tcgcccggcc gctgaccgag      180

cgctaccatg tggtcgccct cgacctgccc ggcttcggcg acagcagcaa gccgcaacag      240

gccagctacg acgtcggcac ccaggccgag cgagtcgcca atttcgccgc cgccatcggc      300

gtgcgccgcc tgcacctggc cggcaactcc atgggcgggc acatcgccgc gctctacgcg      360

gcgcgccatc cggaacaggt gctatcgctg gcgctgatcg acaacgccgg ggtgatgccg      420

gcgcgcaaga gcgaactgtt cgaggacctg gagcgcggcg agaatcccct ggtggtgcgc      480

cagccggaag acttccagaa gctgctcgac ttcgtgttcg tccagcaacc gccgctgccg      540

gcgccgctca agcgctacct cggcgagcgc gcggtagccg cgtcggcgtt caacgcgcag      600

atattcgaac aactgcgcca gcgctacatc ccgctggagc cggaactgcc gaagatcgag      660

gcaccgaccc tgctgctgtg gggcgaccgc gaccgcgtgc tggacgtctc cagcatcgag      720

gtgatgcgtc cgctgctgaa gcggcccagc gtggtgatca tggaaaactg cggacacgtg      780

ccgatggtcg aacgcccgga ggaaaccgcg cagcactacc aggccttcct cgacggcgta      840

cggaacgccc aggtggccgg tcgcattgat ggccgtggaa attctcttgc aaaaaatgta      900

ttattcggtg gaaaaggtaa tgacaagctg tacggcagtg agggggcaga tctgcttgat      960

ggtggagagg gggatgatct cctgaaaggc ggatatggta atgatattta tcgttatctg     1020

tcaggatatg gtcatcatat tattgatgat gatgggggga aagaggataa actcagtttg     1080

gctgatattg atttccggga tgtggccttc aagcgagaag gtaatgacct catcatgtat     1140

aaagctgaag gtaatgttct ttccattggt cataaaaatg gtattacatt caggaactgg     1200

tttgaaaaag agtcaggtga tatctctaat caccagatag agcagatttt tgataaaagt     1260

ggccggataa tcacacctga ttcccttaaa aaggcacttg agtatcaaca gcgtaataat     1320

aaggcaagtt atgtgtatgg gaatgatgca ttagcctatg gaagtcaggg tgatcttaat     1380

ccattaatta atgaaatcag caaaatcatt tcagctgcag gtagcttcga tgttaaagag     1440

gaaagaactg cagcttcttt attgcagttg tccggtaatg ccagtgattt ttcatatgga     1500

cggaactcaa taaccctgac cacatcagca taa                                  1533


<210>  281
<211>  510
<212>  PRT
<213>  Artificial

<220>
<223>  PlbF-HlyA1 fusion

<400>  281

Met Ser Val Arg Thr Val Glu Arg Gly Leu Ala Gly Leu Ser Glu His 
1               5                   10                  15      


Ser Val Gln Val Asp Asn Leu Glu Ile Ala Tyr Leu Glu Gly Gly Ser 
            20                  25                  30          


Glu Lys Asn Pro Thr Leu Leu Leu Ile His Gly Phe Gly Ala Asp Lys 
        35                  40                  45              


Asp Asn Trp Leu Arg Phe Ala Arg Pro Leu Thr Glu Arg Tyr His Val 
    50                  55                  60                  


Val Ala Leu Asp Leu Pro Gly Phe Gly Asp Ser Ser Lys Pro Gln Gln 
65                  70                  75                  80  


Ala Ser Tyr Asp Val Gly Thr Gln Ala Glu Arg Val Ala Asn Phe Ala 
                85                  90                  95      


Ala Ala Ile Gly Val Arg Arg Leu His Leu Ala Gly Asn Ser Met Gly 
            100                 105                 110         


Gly His Ile Ala Ala Leu Tyr Ala Ala Arg His Pro Glu Gln Val Leu 
        115                 120                 125             


Ser Leu Ala Leu Ile Asp Asn Ala Gly Val Met Pro Ala Arg Lys Ser 
    130                 135                 140                 


Glu Leu Phe Glu Asp Leu Glu Arg Gly Glu Asn Pro Leu Val Val Arg 
145                 150                 155                 160 


Gln Pro Glu Asp Phe Gln Lys Leu Leu Asp Phe Val Phe Val Gln Gln 
                165                 170                 175     


Pro Pro Leu Pro Ala Pro Leu Lys Arg Tyr Leu Gly Glu Arg Ala Val 
            180                 185                 190         


Ala Ala Ser Ala Phe Asn Ala Gln Ile Phe Glu Gln Leu Arg Gln Arg 
        195                 200                 205             


Tyr Ile Pro Leu Glu Pro Glu Leu Pro Lys Ile Glu Ala Pro Thr Leu 
    210                 215                 220                 


Leu Leu Trp Gly Asp Arg Asp Arg Val Leu Asp Val Ser Ser Ile Glu 
225                 230                 235                 240 


Val Met Arg Pro Leu Leu Lys Arg Pro Ser Val Val Ile Met Glu Asn 
                245                 250                 255     


Cys Gly His Val Pro Met Val Glu Arg Pro Glu Glu Thr Ala Gln His 
            260                 265                 270         


Tyr Gln Ala Phe Leu Asp Gly Val Arg Asn Ala Gln Val Ala Gly Arg 
        275                 280                 285             


Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly 
    290                 295                 300                 


Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp 
305                 310                 315                 320 


Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile 
                325                 330                 335     


Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly 
            340                 345                 350         


Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val 
        355                 360                 365             


Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly 
    370                 375                 380                 


Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp 
385                 390                 395                 400 


Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile 
                405                 410                 415     


Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala 
            420                 425                 430         


Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn 
        435                 440                 445             


Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn 
    450                 455                 460                 


Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu 
465                 470                 475                 480 


Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp 
                485                 490                 495     


Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
            500                 505                 510 


<210>  282
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  282
agaggtaatt aaatgcagac gctgttggtc g                                      31


<210>  283
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  283
tgcaagagaa tttccacggc catcaataag cagcggtttc agcg                        44


<210>  284
<211>  1371
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  284
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgcagacgct gttggtcgtg      180

ggcgatagta tcagcgccgc tttgggactg gataccagcc agggctgggt cgccctgctg      240

cagaagcgcc tcgccgacga aggttacgac taccgggtgg tgaacgcctc gatcagcggc      300

gacacctccg cgggtggcct ggcgcgcctg ccggcgctgc ttgccgagga gaagccggcg      360

ctggtggtga tcgagctggg aggcaacgac gggctgcgcg gaatggcacc ggcgcaattg      420

caacagaatc ttgccagcat ggcgcaaaag gcccgggcgg aaggagcgaa ggtgctgctg      480

ctgggtatcc agttgccacc gaactacggc ccgcgctaca tcgaggcctt ttccagggtc      540

tacggcgcgg tcgcggcgca ggaaaagacc gccctggtgc cgtttttcct cgaaggggtc      600

ggcggggtcc aggggatgat gcaggcggat ggcatccatc cggcgctcgc cgcccagccg      660

aggctcctgg aaaatgtctg gccgacgctg aaaccgctgc ttattgatgg ccgtggaaat      720

tctcttgcaa aaaatgtatt attcggtgga aaaggtaatg acaagctgta cggcagtgag      780

ggggcagatc tgcttgatgg tggagagggg gatgatctcc tgaaaggcgg atatggtaat      840

gatatttatc gttatctgtc aggatatggt catcatatta ttgatgatga tggggggaaa      900

gaggataaac tcagtttggc tgatattgat ttccgggatg tggccttcaa gcgagaaggt      960

aatgacctca tcatgtataa agctgaaggt aatgttcttt ccattggtca taaaaatggt     1020

attacattca ggaactggtt tgaaaaagag tcaggtgata tctctaatca ccagatagag     1080

cagatttttg ataaaagtgg ccggataatc acacctgatt cccttaaaaa ggcacttgag     1140

tatcaacagc gtaataataa ggcaagttat gtgtatggga atgatgcatt agcctatgga     1200

agtcagggtg atcttaatcc attaattaat gaaatcagca aaatcatttc agctgcaggt     1260

agcttcgatg ttaaagagga aagaactgca gcttctttat tgcagttgtc cggtaatgcc     1320

agtgattttt catatggacg gaactcaata accctgacca catcagcata a              1371


<210>  285
<211>  1212
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  285
atgcagacgc tgttggtcgt gggcgatagt atcagcgccg ctttgggact ggataccagc       60

cagggctggg tcgccctgct gcagaagcgc ctcgccgacg aaggttacga ctaccgggtg      120

gtgaacgcct cgatcagcgg cgacacctcc gcgggtggcc tggcgcgcct gccggcgctg      180

cttgccgagg agaagccggc gctggtggtg atcgagctgg gaggcaacga cgggctgcgc      240

ggaatggcac cggcgcaatt gcaacagaat cttgccagca tggcgcaaaa ggcccgggcg      300

gaaggagcga aggtgctgct gctgggtatc cagttgccac cgaactacgg cccgcgctac      360

atcgaggcct tttccagggt ctacggcgcg gtcgcggcgc aggaaaagac cgccctggtg      420

ccgtttttcc tcgaaggggt cggcggggtc caggggatga tgcaggcgga tggcatccat      480

ccggcgctcg ccgcccagcc gaggctcctg gaaaatgtct ggccgacgct gaaaccgctg      540

cttattgatg gccgtggaaa ttctcttgca aaaaatgtat tattcggtgg aaaaggtaat      600

gacaagctgt acggcagtga gggggcagat ctgcttgatg gtggagaggg ggatgatctc      660

ctgaaaggcg gatatggtaa tgatatttat cgttatctgt caggatatgg tcatcatatt      720

attgatgatg atggggggaa agaggataaa ctcagtttgg ctgatattga tttccgggat      780

gtggccttca agcgagaagg taatgacctc atcatgtata aagctgaagg taatgttctt      840

tccattggtc ataaaaatgg tattacattc aggaactggt ttgaaaaaga gtcaggtgat      900

atctctaatc accagataga gcagattttt gataaaagtg gccggataat cacacctgat      960

tcccttaaaa aggcacttga gtatcaacag cgtaataata aggcaagtta tgtgtatggg     1020

aatgatgcat tagcctatgg aagtcagggt gatcttaatc cattaattaa tgaaatcagc     1080

aaaatcattt cagctgcagg tagcttcgat gttaaagagg aaagaactgc agcttcttta     1140

ttgcagttgt ccggtaatgc cagtgatttt tcatatggac ggaactcaat aaccctgacc     1200

acatcagcat aa                                                         1212


<210>  286
<211>  403
<212>  PRT
<213>  Artificial

<220>
<223>  tesA-HlyA1 fusion

<400>  286

Met Gln Thr Leu Leu Val Val Gly Asp Ser Ile Ser Ala Ala Leu Gly 
1               5                   10                  15      


Leu Asp Thr Ser Gln Gly Trp Val Ala Leu Leu Gln Lys Arg Leu Ala 
            20                  25                  30          


Asp Glu Gly Tyr Asp Tyr Arg Val Val Asn Ala Ser Ile Ser Gly Asp 
        35                  40                  45              


Thr Ser Ala Gly Gly Leu Ala Arg Leu Pro Ala Leu Leu Ala Glu Glu 
    50                  55                  60                  


Lys Pro Ala Leu Val Val Ile Glu Leu Gly Gly Asn Asp Gly Leu Arg 
65                  70                  75                  80  


Gly Met Ala Pro Ala Gln Leu Gln Gln Asn Leu Ala Ser Met Ala Gln 
                85                  90                  95      


Lys Ala Arg Ala Glu Gly Ala Lys Val Leu Leu Leu Gly Ile Gln Leu 
            100                 105                 110         


Pro Pro Asn Tyr Gly Pro Arg Tyr Ile Glu Ala Phe Ser Arg Val Tyr 
        115                 120                 125             


Gly Ala Val Ala Ala Gln Glu Lys Thr Ala Leu Val Pro Phe Phe Leu 
    130                 135                 140                 


Glu Gly Val Gly Gly Val Gln Gly Met Met Gln Ala Asp Gly Ile His 
145                 150                 155                 160 


Pro Ala Leu Ala Ala Gln Pro Arg Leu Leu Glu Asn Val Trp Pro Thr 
                165                 170                 175     


Leu Lys Pro Leu Leu Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn 
            180                 185                 190         


Val Leu Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly 
        195                 200                 205             


Ala Asp Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly 
    210                 215                 220                 


Tyr Gly Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile 
225                 230                 235                 240 


Ile Asp Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile 
                245                 250                 255     


Asp Phe Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met 
            260                 265                 270         


Tyr Lys Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile 
        275                 280                 285             


Thr Phe Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His 
    290                 295                 300                 


Gln Ile Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp 
305                 310                 315                 320 


Ser Leu Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser 
                325                 330                 335     


Tyr Val Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu 
            340                 345                 350         


Asn Pro Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser 
        355                 360                 365             


Phe Asp Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser 
    370                 375                 380                 


Gly Asn Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr 
385                 390                 395                 400 


Thr Ser Ala 
            


<210>  287
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  287
agaggtaatt aaatgaaaat cgaagaaggt aaac                                   34


<210>  288
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  288
tgcaagagaa tttccacggc catcaatctt ggtgatacga gtctg                       45


<210>  289
<211>  1941
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  289
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgaaaatcga agaaggtaaa      180

ctggtaatct ggattaacgg cgataaaggc tataacggtc tcgctgaagt cggtaagaaa      240

ttcgagaaag ataccggaat taaagtcacc gttgagcatc cggataaact ggaagagaaa      300

ttcccacagg ttgcggcaac tggcgatggc cctgacatta tcttctgggc acacgaccgc      360

tttggtggct acgctcaatc tggcctgttg gctgaaatca ccccggacaa agcgttccag      420

gacaagctgt atccgtttac ctgggatgcc gtacgttaca acggcaagct gattgcttac      480

ccgatcgctg ttgaagcgtt atcgctgatt tataacaaag atctgctgcc gaacccgcca      540

aaaacctggg aagagatccc ggcgctggat aaagaactga aagcgaaagg taagagcgcg      600

ctgatgttca acctgcaaga accgtacttc acctggccgc tgattgctgc tgacgggggt      660

tatgcgttca agtatgaaaa cggcaagtac gacattaaag acgtgggcgt ggataacgct      720

ggcgcgaaag cgggtctgac cttcctggtt gacctgatta aaaacaaaca catgaatgca      780

gacaccgatt actccatcgc agaagctgcc tttaataaag gcgaaacagc gatgaccatc      840

aacggcccgt gggcatggtc caacatcgac accagcaaag tgaattatgg tgtaacggta      900

ctgccgacct tcaagggtca accatccaaa ccgttcgttg gcgtgctgag cgcaggtatt      960

aacgccgcca gtccgaacaa agagctggcg aaagagttcc tcgaaaacta tctgctgact     1020

gatgaaggtc tggaagcggt taataaagac aaaccgctgg gtgccgtagc gctgaagtct     1080

tacgaggaag agttggcgaa agatccacgt attgccgcca ccatggaaaa cgcccagaaa     1140

ggtgaaatca tgccgaacat cccgcagatg tccgctttct ggtatgccgt gcgtactgcg     1200

gtgatcaacg ccgccagcgg tcgtcagact gtcgatgaag ccctgaaaga cgcgcagact     1260

cgtatcacca agattgatgg ccgtggaaat tctcttgcaa aaaatgtatt attcggtgga     1320

aaaggtaatg acaagctgta cggcagtgag ggggcagatc tgcttgatgg tggagagggg     1380

gatgatctcc tgaaaggcgg atatggtaat gatatttatc gttatctgtc aggatatggt     1440

catcatatta ttgatgatga tggggggaaa gaggataaac tcagtttggc tgatattgat     1500

ttccgggatg tggccttcaa gcgagaaggt aatgacctca tcatgtataa agctgaaggt     1560

aatgttcttt ccattggtca taaaaatggt attacattca ggaactggtt tgaaaaagag     1620

tcaggtgata tctctaatca ccagatagag cagatttttg ataaaagtgg ccggataatc     1680

acacctgatt cccttaaaaa ggcacttgag tatcaacagc gtaataataa ggcaagttat     1740

gtgtatggga atgatgcatt agcctatgga agtcagggtg atcttaatcc attaattaat     1800

gaaatcagca aaatcatttc agctgcaggt agcttcgatg ttaaagagga aagaactgca     1860

gcttctttat tgcagttgtc cggtaatgcc agtgattttt catatggacg gaactcaata     1920

accctgacca catcagcata a                                               1941


<210>  290
<211>  1782
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  290
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt       60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat      120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt      180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc      240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac      300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa      360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg      420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg      480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa      540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt      600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa      660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa      720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt      780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc gaaagagttc      840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg      900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc      960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc     1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa     1080

gccctgaaag acgcgcagac tcgtatcacc aagattgatg gccgtggaaa ttctcttgca     1140

aaaaatgtat tattcggtgg aaaaggtaat gacaagctgt acggcagtga gggggcagat     1200

ctgcttgatg gtggagaggg ggatgatctc ctgaaaggcg gatatggtaa tgatatttat     1260

cgttatctgt caggatatgg tcatcatatt attgatgatg atggggggaa agaggataaa     1320

ctcagtttgg ctgatattga tttccgggat gtggccttca agcgagaagg taatgacctc     1380

atcatgtata aagctgaagg taatgttctt tccattggtc ataaaaatgg tattacattc     1440

aggaactggt ttgaaaaaga gtcaggtgat atctctaatc accagataga gcagattttt     1500

gataaaagtg gccggataat cacacctgat tcccttaaaa aggcacttga gtatcaacag     1560

cgtaataata aggcaagtta tgtgtatggg aatgatgcat tagcctatgg aagtcagggt     1620

gatcttaatc cattaattaa tgaaatcagc aaaatcattt cagctgcagg tagcttcgat     1680

gttaaagagg aaagaactgc agcttcttta ttgcagttgt ccggtaatgc cagtgatttt     1740

tcatatggac ggaactcaat aaccctgacc acatcagcat aa                        1782


<210>  291
<211>  593
<212>  PRT
<213>  Artificial

<220>
<223>  MBP-HlyA1 fusion

<400>  291

Met Lys Ile Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Arg 
        355                 360                 365             


Ile Thr Lys Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu 
    370                 375                 380                 


Phe Gly Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp 
385                 390                 395                 400 


Leu Leu Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly 
                405                 410                 415     


Asn Asp Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp 
            420                 425                 430         


Asp Asp Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe 
        435                 440                 445             


Arg Asp Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys 
    450                 455                 460                 


Ala Glu Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe 
465                 470                 475                 480 


Arg Asn Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile 
                485                 490                 495     


Glu Gln Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu 
            500                 505                 510         


Lys Lys Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val 
        515                 520                 525             


Tyr Gly Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro 
    530                 535                 540                 


Leu Ile Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp 
545                 550                 555                 560 


Val Lys Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn 
                565                 570                 575     


Ala Ser Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser 
            580                 585                 590         


Ala 
    


<210>  292
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  292
agaggtaatt aaatggaaaa cagatggcag gtg                                    33


<210>  293
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  293
tgcaagagaa tttccacggc catcaatgtg tccattcatt gtgtggct                    48


<210>  294
<211>  1404
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  294
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggaaaacag atggcaggtg      180

atgattgtgt ggcaagtaga caggatgagg attaacacat ggaaaagatt agtaaaacac      240

catatgtata tttcaaggaa agctaaggac tggttttata gacatcacta tgaaagtact      300

aatccaaaaa taagttcaga agtacacatc ccactagggg atgctaaatt agtaataaca      360

acatattggg gtctgcatac aggagaaaga gactggcatt tgggtcaggg agtctccata      420

gaatggagga aaaagagata tagcacacaa gtagaccctg acctagcaga ccaactaatt      480

catctgcact attttgattg tttttcagaa tctgctataa gaaataccat attaggacgt      540

atagttagtc ctaggtgtga atatcaagca ggacataaca aggtaggatc tctacagtac      600

ttggcactag cagcattaat aaaaccaaaa cagataaagc cacctttgcc tagtgttagg      660

aaactgacag aggacagatg gaacaagccc cagaagacca agggccacag agggagccac      720

acaatgaatg gacacattga tggccgtgga aattctcttg caaaaaatgt attattcggt      780

ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga tggtggagag      840

ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct gtcaggatat      900

ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt ggctgatatt      960

gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta taaagctgaa     1020

ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg gtttgaaaaa     1080

gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag tggccggata     1140

atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa taaggcaagt     1200

tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa tccattaatt     1260

aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga ggaaagaact     1320

gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg acggaactca     1380

ataaccctga ccacatcagc ataa                                            1404


<210>  295
<211>  1404
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  295
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tggaaaacag atggcaggtg      180

atgattgtgt ggcaagtaga caggatgagg attaacacat ggaaaagatt agtaaaacac      240

catatgtata tttcaaggaa agctaaggac tggttttata gacatcacta tgaaagtact      300

aatccaaaaa taagttcaga agtacacatc ccactagggg atgctaaatt agtaataaca      360

acatattggg gtctgcatac aggagaaaga gactggcatt tgggtcaggg agtctccata      420

gaatggagga aaaagagata tagcacacaa gtagaccctg acctagcaga ccaactaatt      480

catctgcact attttgattg tttttcagaa tctgctataa gaaataccat attaggacgt      540

atagttagtc ctaggtgtga atatcaagca ggacataaca aggtaggatc tctacagtac      600

ttggcactag cagcattaat aaaaccaaaa cagataaagc cacctttgcc tagtgttagg      660

aaactgacag aggacagatg gaacaagccc cagaagacca agggccacag agggagccac      720

acaatgaatg gacacattga tggccgtgga aattctcttg caaaaaatgt attattcggt      780

ggaaaaggta atgacaagct gtacggcagt gagggggcag atctgcttga tggtggagag      840

ggggatgatc tcctgaaagg cggatatggt aatgatattt atcgttatct gtcaggatat      900

ggtcatcata ttattgatga tgatgggggg aaagaggata aactcagttt ggctgatatt      960

gatttccggg atgtggcctt caagcgagaa ggtaatgacc tcatcatgta taaagctgaa     1020

ggtaatgttc tttccattgg tcataaaaat ggtattacat tcaggaactg gtttgaaaaa     1080

gagtcaggtg atatctctaa tcaccagata gagcagattt ttgataaaag tggccggata     1140

atcacacctg attcccttaa aaaggcactt gagtatcaac agcgtaataa taaggcaagt     1200

tatgtgtatg ggaatgatgc attagcctat ggaagtcagg gtgatcttaa tccattaatt     1260

aatgaaatca gcaaaatcat ttcagctgca ggtagcttcg atgttaaaga ggaaagaact     1320

gcagcttctt tattgcagtt gtccggtaat gccagtgatt tttcatatgg acggaactca     1380

ataaccctga ccacatcagc ataa                                            1404


<210>  296
<211>  414
<212>  PRT
<213>  Artificial

<220>
<223>  Vif-HlyA1 fusion

<400>  296

Met Glu Asn Arg Trp Gln Val Met Ile Val Trp Gln Val Asp Arg Met 
1               5                   10                  15      


Arg Ile Asn Thr Trp Lys Arg Leu Val Lys His His Met Tyr Ile Ser 
            20                  25                  30          


Arg Lys Ala Lys Asp Trp Phe Tyr Arg His His Tyr Glu Ser Thr Asn 
        35                  40                  45              


Pro Lys Ile Ser Ser Glu Val His Ile Pro Leu Gly Asp Ala Lys Leu 
    50                  55                  60                  


Val Ile Thr Thr Tyr Trp Gly Leu His Thr Gly Glu Arg Asp Trp His 
65                  70                  75                  80  


Leu Gly Gln Gly Val Ser Ile Glu Trp Arg Lys Lys Arg Tyr Ser Thr 
                85                  90                  95      


Gln Val Asp Pro Asp Leu Ala Asp Gln Leu Ile His Leu His Tyr Phe 
            100                 105                 110         


Asp Cys Phe Ser Glu Ser Ala Ile Arg Asn Thr Ile Leu Gly Arg Ile 
        115                 120                 125             


Val Ser Pro Arg Cys Glu Tyr Gln Ala Gly His Asn Lys Val Gly Ser 
    130                 135                 140                 


Leu Gln Tyr Leu Ala Leu Ala Ala Leu Ile Lys Pro Lys Gln Ile Lys 
145                 150                 155                 160 


Pro Pro Leu Pro Ser Val Arg Lys Leu Thr Glu Asp Arg Trp Asn Lys 
                165                 170                 175     


Pro Gln Lys Thr Lys Gly His Arg Gly Ser His Thr Met Asn Gly His 
            180                 185                 190         


Ile Asp Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly 
        195                 200                 205             


Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp 
    210                 215                 220                 


Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile 
225                 230                 235                 240 


Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly 
                245                 250                 255     


Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val 
            260                 265                 270         


Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly 
        275                 280                 285             


Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp 
    290                 295                 300                 


Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile 
305                 310                 315                 320 


Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala 
                325                 330                 335     


Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn 
            340                 345                 350         


Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn 
        355                 360                 365             


Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu 
    370                 375                 380                 


Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp 
385                 390                 395                 400 


Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
                405                 410                 


<210>  297
<211>  34
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  297
agaggtaatt aaatgggcat ctttagctat aagg                                   34


<210>  298
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  298
tgcaagagaa tttccggcca acaccacctg                                        30


<210>  299
<211>  2655
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  299
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgggcatctt tagctataag      180

gatctggacg aaaacgcgtc aaaggcgctg ttttccgacg ccttggccat ctctacctac      240

gcttaccaca atatcgataa cggcttcgat gaaggctatc accagaccgg tttcgggctc      300

ggtctgccgc tgacgctgat cacggcgctc atcggcagca cccagtcgca gggcggcctg      360

cccggccttc cctggaaccc cgactccgaa caggccgcgc aggaagcggt gaacaatgcc      420

ggctggtcgg tgatcagcgc cacgcagttg ggttacgccg gcaaaaccga tgcgcgcggc      480

acctactacg gcgagaccgc cggttacacc accgcgcagg ccgaggtgct gggaaaatat      540

gacagcgaag gcaatctcac cgccattggc atctcatttc gcggcaccag cggcccgcgc      600

gagtcgttga tcggcgatac catcggcgat gtgattaacg atctgctggc cgggttcggg      660

ccgaaaggct acgccgacgg ctacacgctg aaggcgttcg gcaacttgct gggcgacgtg      720

gcgaaattcg cgcaggccca cgggctgagc ggcgaggacg tggtggtcag cggccacagc      780

ctcggcgggc tggcggtcaa cagcatggcg gcgcagagcg acgccaactg gggcggcttc      840

tacgcgcagt ccaactatgt cgccttcgcc tcgccgaccc agtacgaagc cggcggcaag      900

gtgatcaaca tcggctatga gaacgatccg gtgtttcgcg cgctcgacgg cacctcgctg      960

accctgccgt cattgggcgt tcacgatgcg ccgcatacct ccgccaccaa caatatcgtc     1020

aacttcaacg atcactacgc gtcggacgcc tggaatctgt tgccgttctc cattctcaac     1080

attccgacct ggctatccca cctgccgttc ttctatcagg atggcctgat gcgggtgctg     1140

aactccgagt tttattcgct gaccgacaaa gactcgacca tcatcgtctc caacctgtcg     1200

aacgtgacgc gcggcaatac ctgggtggaa gacctgaacc gcaacgcgga aacgcacagc     1260

gggccgacgt ttatcatcgg cagcgacggc aatgatttga tcaagggcgg caaaggcaat     1320

gactatctcg agggccgcga cggcgacgat atcttccgcg acgccggcgg ctataacctg     1380

atcgccggcg gcaaaggcca caatatcttc gatacccagc aggcgttgaa gaataccgag     1440

gtcgcctacg acggcaacac gctttacctg cgcgacgcca agggcggcat tacgctggca     1500

gacgacatca gcaccctgcg cagcaaagaa acctcctggc ttatcttcaa caaagaagtg     1560

gatcatcagg taaccgccgc cggattgaaa tcggactcag gcctcaaagc ctatgccgcc     1620

gccaccggcg gcgacggcga tgacgtcctg caggctcgca gccacgacgc ctggctgttc     1680

ggcaacgccg gcaacgacac gctgatcggc cacgccggcg gcaacctgac cttcgtcggc     1740

ggcagcggcg atgacatcct gaagggcgtc ggcaacggca acaccttcct gttcagcggc     1800

gatttcggcc gcgaccagct gtatggcttc aacgccagcg ataaactggt gtttatcggc     1860

accgaaggtg ccagcggcaa tatccgcgac tacgccacgc agcaaaacga cgatctggtg     1920

ctggccttcg gccacagcca ggtcacgctg atcggcgtct cgctcgatca catcagcacc     1980

gatcaggtgg tgttggccgg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt     2040

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat     2100

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat     2160

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg     2220

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt     2280

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt     2340

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct     2400

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat     2460

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc     2520

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct     2580

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg     2640

accacatcag cataa                                                      2655


<210>  300
<211>  2655
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  300
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgggcatctt tagctataag      180

gatctggacg aaaacgcgtc aaaggcgctg ttttccgacg ccttggccat ctctacctac      240

gcttaccaca atatcgataa cggcttcgat gaaggctatc accagaccgg tttcgggctc      300

ggtctgccgc tgacgctgat cacggcgctc atcggcagca cccagtcgca gggcggcctg      360

cccggccttc cctggaaccc cgactccgaa caggccgcgc aggaagcggt gaacaatgcc      420

ggctggtcgg tgatcagcgc cacgcagttg ggttacgccg gcaaaaccga tgcgcgcggc      480

acctactacg gcgagaccgc cggttacacc accgcgcagg ccgaggtgct gggaaaatat      540

gacagcgaag gcaatctcac cgccattggc atctcatttc gcggcaccag cggcccgcgc      600

gagtcgttga tcggcgatac catcggcgat gtgattaacg atctgctggc cgggttcggg      660

ccgaaaggct acgccgacgg ctacacgctg aaggcgttcg gcaacttgct gggcgacgtg      720

gcgaaattcg cgcaggccca cgggctgagc ggcgaggacg tggtggtcag cggccacagc      780

ctcggcgggc tggcggtcaa cagcatggcg gcgcagagcg acgccaactg gggcggcttc      840

tacgcgcagt ccaactatgt cgccttcgcc tcgccgaccc agtacgaagc cggcggcaag      900

gtgatcaaca tcggctatga gaacgatccg gtgtttcgcg cgctcgacgg cacctcgctg      960

accctgccgt cattgggcgt tcacgatgcg ccgcatacct ccgccaccaa caatatcgtc     1020

aacttcaacg atcactacgc gtcggacgcc tggaatctgt tgccgttctc cattctcaac     1080

attccgacct ggctatccca cctgccgttc ttctatcagg atggcctgat gcgggtgctg     1140

aactccgagt tttattcgct gaccgacaaa gactcgacca tcatcgtctc caacctgtcg     1200

aacgtgacgc gcggcaatac ctgggtggaa gacctgaacc gcaacgcgga aacgcacagc     1260

gggccgacgt ttatcatcgg cagcgacggc aatgatttga tcaagggcgg caaaggcaat     1320

gactatctcg agggccgcga cggcgacgat atcttccgcg acgccggcgg ctataacctg     1380

atcgccggcg gcaaaggcca caatatcttc gatacccagc aggcgttgaa gaataccgag     1440

gtcgcctacg acggcaacac gctttacctg cgcgacgcca agggcggcat tacgctggca     1500

gacgacatca gcaccctgcg cagcaaagaa acctcctggc ttatcttcaa caaagaagtg     1560

gatcatcagg taaccgccgc cggattgaaa tcggactcag gcctcaaagc ctatgccgcc     1620

gccaccggcg gcgacggcga tgacgtcctg caggctcgca gccacgacgc ctggctgttc     1680

ggcaacgccg gcaacgacac gctgatcggc cacgccggcg gcaacctgac cttcgtcggc     1740

ggcagcggcg atgacatcct gaagggcgtc ggcaacggca acaccttcct gttcagcggc     1800

gatttcggcc gcgaccagct gtatggcttc aacgccagcg ataaactggt gtttatcggc     1860

accgaaggtg ccagcggcaa tatccgcgac tacgccacgc agcaaaacga cgatctggtg     1920

ctggccttcg gccacagcca ggtcacgctg atcggcgtct cgctcgatca catcagcacc     1980

gatcaggtgg tgttggccgg aaattctctt gcaaaaaatg tattattcgg tggaaaaggt     2040

aatgacaagc tgtacggcag tgagggggca gatctgcttg atggtggaga gggggatgat     2100

ctcctgaaag gcggatatgg taatgatatt tatcgttatc tgtcaggata tggtcatcat     2160

attattgatg atgatggggg gaaagaggat aaactcagtt tggctgatat tgatttccgg     2220

gatgtggcct tcaagcgaga aggtaatgac ctcatcatgt ataaagctga aggtaatgtt     2280

ctttccattg gtcataaaaa tggtattaca ttcaggaact ggtttgaaaa agagtcaggt     2340

gatatctcta atcaccagat agagcagatt tttgataaaa gtggccggat aatcacacct     2400

gattccctta aaaaggcact tgagtatcaa cagcgtaata ataaggcaag ttatgtgtat     2460

gggaatgatg cattagccta tggaagtcag ggtgatctta atccattaat taatgaaatc     2520

agcaaaatca tttcagctgc aggtagcttc gatgttaaag aggaaagaac tgcagcttct     2580

ttattgcagt tgtccggtaa tgccagtgat ttttcatatg gacggaactc aataaccctg     2640

accacatcag cataa                                                      2655


<210>  301
<211>  831
<212>  PRT
<213>  Artificial

<220>
<223>  LipA-HlyA1 fusion

<400>  301

Met Gly Ile Phe Ser Tyr Lys Asp Leu Asp Glu Asn Ala Ser Lys Ala 
1               5                   10                  15      


Leu Phe Ser Asp Ala Leu Ala Ile Ser Thr Tyr Ala Tyr His Asn Ile 
            20                  25                  30          


Asp Asn Gly Phe Asp Glu Gly Tyr His Gln Thr Gly Phe Gly Leu Gly 
        35                  40                  45              


Leu Pro Leu Thr Leu Ile Thr Ala Leu Ile Gly Ser Thr Gln Ser Gln 
    50                  55                  60                  


Gly Gly Leu Pro Gly Leu Pro Trp Asn Pro Asp Ser Glu Gln Ala Ala 
65                  70                  75                  80  


Gln Glu Ala Val Asn Asn Ala Gly Trp Ser Val Ile Ser Ala Thr Gln 
                85                  90                  95      


Leu Gly Tyr Ala Gly Lys Thr Asp Ala Arg Gly Thr Tyr Tyr Gly Glu 
            100                 105                 110         


Thr Ala Gly Tyr Thr Thr Ala Gln Ala Glu Val Leu Gly Lys Tyr Asp 
        115                 120                 125             


Ser Glu Gly Asn Leu Thr Ala Ile Gly Ile Ser Phe Arg Gly Thr Ser 
    130                 135                 140                 


Gly Pro Arg Glu Ser Leu Ile Gly Asp Thr Ile Gly Asp Val Ile Asn 
145                 150                 155                 160 


Asp Leu Leu Ala Gly Phe Gly Pro Lys Gly Tyr Ala Asp Gly Tyr Thr 
                165                 170                 175     


Leu Lys Ala Phe Gly Asn Leu Leu Gly Asp Val Ala Lys Phe Ala Gln 
            180                 185                 190         


Ala His Gly Leu Ser Gly Glu Asp Val Val Val Ser Gly His Ser Leu 
        195                 200                 205             


Gly Gly Leu Ala Val Asn Ser Met Ala Ala Gln Ser Asp Ala Asn Trp 
    210                 215                 220                 


Gly Gly Phe Tyr Ala Gln Ser Asn Tyr Val Ala Phe Ala Ser Pro Thr 
225                 230                 235                 240 


Gln Tyr Glu Ala Gly Gly Lys Val Ile Asn Ile Gly Tyr Glu Asn Asp 
                245                 250                 255     


Pro Val Phe Arg Ala Leu Asp Gly Thr Ser Leu Thr Leu Pro Ser Leu 
            260                 265                 270         


Gly Val His Asp Ala Pro His Thr Ser Ala Thr Asn Asn Ile Val Asn 
        275                 280                 285             


Phe Asn Asp His Tyr Ala Ser Asp Ala Trp Asn Leu Leu Pro Phe Ser 
    290                 295                 300                 


Ile Leu Asn Ile Pro Thr Trp Leu Ser His Leu Pro Phe Phe Tyr Gln 
305                 310                 315                 320 


Asp Gly Leu Met Arg Val Leu Asn Ser Glu Phe Tyr Ser Leu Thr Asp 
                325                 330                 335     


Lys Asp Ser Thr Ile Ile Val Ser Asn Leu Ser Asn Val Thr Arg Gly 
            340                 345                 350         


Asn Thr Trp Val Glu Asp Leu Asn Arg Asn Ala Glu Thr His Ser Gly 
        355                 360                 365             


Pro Thr Phe Ile Ile Gly Ser Asp Gly Asn Asp Leu Ile Lys Gly Gly 
    370                 375                 380                 


Lys Gly Asn Asp Tyr Leu Glu Gly Arg Asp Gly Asp Asp Ile Phe Arg 
385                 390                 395                 400 


Asp Ala Gly Gly Tyr Asn Leu Ile Ala Gly Gly Lys Gly His Asn Ile 
                405                 410                 415     


Phe Asp Thr Gln Gln Ala Leu Lys Asn Thr Glu Val Ala Tyr Asp Gly 
            420                 425                 430         


Asn Thr Leu Tyr Leu Arg Asp Ala Lys Gly Gly Ile Thr Leu Ala Asp 
        435                 440                 445             


Asp Ile Ser Thr Leu Arg Ser Lys Glu Thr Ser Trp Leu Ile Phe Asn 
    450                 455                 460                 


Lys Glu Val Asp His Gln Val Thr Ala Ala Gly Leu Lys Ser Asp Ser 
465                 470                 475                 480 


Gly Leu Lys Ala Tyr Ala Ala Ala Thr Gly Gly Asp Gly Asp Asp Val 
                485                 490                 495     


Leu Gln Ala Arg Ser His Asp Ala Trp Leu Phe Gly Asn Ala Gly Asn 
            500                 505                 510         


Asp Thr Leu Ile Gly His Ala Gly Gly Asn Leu Thr Phe Val Gly Gly 
        515                 520                 525             


Ser Gly Asp Asp Ile Leu Lys Gly Val Gly Asn Gly Asn Thr Phe Leu 
    530                 535                 540                 


Phe Ser Gly Asp Phe Gly Arg Asp Gln Leu Tyr Gly Phe Asn Ala Ser 
545                 550                 555                 560 


Asp Lys Leu Val Phe Ile Gly Thr Glu Gly Ala Ser Gly Asn Ile Arg 
                565                 570                 575     


Asp Tyr Ala Thr Gln Gln Asn Asp Asp Leu Val Leu Ala Phe Gly His 
            580                 585                 590         


Ser Gln Val Thr Leu Ile Gly Val Ser Leu Asp His Ile Ser Thr Asp 
        595                 600                 605             


Gln Val Val Leu Ala Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly 
    610                 615                 620                 


Gly Lys Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu 
625                 630                 635                 640 


Asp Gly Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp 
                645                 650                 655     


Ile Tyr Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp 
            660                 665                 670         


Gly Gly Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp 
        675                 680                 685             


Val Ala Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu 
    690                 695                 700                 


Gly Asn Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn 
705                 710                 715                 720 


Trp Phe Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln 
                725                 730                 735     


Ile Phe Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys 
            740                 745                 750         


Ala Leu Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly 
        755                 760                 765             


Asn Asp Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile 
    770                 775                 780                 


Asn Glu Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys 
785                 790                 795                 800 


Glu Glu Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser 
                805                 810                 815     


Asp Phe Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
            820                 825                 830     


<210>  302
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  302
agaggtaatt aaatgagcga agaaccgccg att                                    33


<210>  303
<211>  44
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  303
cggcggttct tcgctgataa tttccatcag tttacggttg ctgt                        44


<210>  304
<211>  1065
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  304
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgagcgaaga accgccgatt      180

tctctggatc tgacctttca tctgctgcgt gaagtgctgg aaatggcacg tgcagaacag      240

ctggcacagc aggcgcacag caaccgtaaa ctgatggaaa ttatcagcga agaaccgccg      300

atttctctgg atctgacctt tcatctgctg cgtgaagtgc tggaaatggc acgtgcagaa      360

cagctggcac agcaggcgca cagcaaccgt aaactgatgg aaattatcgg aaattctctt      420

gcaaaaaatg tattattcgg tggaaaaggt aatgacaagc tgtacggcag tgagggggca      480

gatctgcttg atggtggaga gggggatgat ctcctgaaag gcggatatgg taatgatatt      540

tatcgttatc tgtcaggata tggtcatcat attattgatg atgatggggg gaaagaggat      600

aaactcagtt tggctgatat tgatttccgg gatgtggcct tcaagcgaga aggtaatgac      660

ctcatcatgt ataaagctga aggtaatgtt ctttccattg gtcataaaaa tggtattaca      720

ttcaggaact ggtttgaaaa agagtcaggt gatatctcta atcaccagat agagcagatt      780

tttgataaaa gtggccggat aatcacacct gattccctta aaaaggcact tgagtatcaa      840

cagcgtaata ataaggcaag ttatgtgtat gggaatgatg cattagccta tggaagtcag      900

ggtgatctta atccattaat taatgaaatc agcaaaatca tttcagctgc aggtagcttc      960

gatgttaaag aggaaagaac tgcagcttct ttattgcagt tgtccggtaa tgccagtgat     1020

ttttcatatg gacggaactc aataaccctg accacatcag cataa                     1065


<210>  305
<211>  906
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  305
atgagcgaag aaccgccgat ttctctggat ctgacctttc atctgctgcg tgaagtgctg       60

gaaatggcac gtgcagaaca gctggcacag caggcgcaca gcaaccgtaa actgatggaa      120

attatcagcg aagaaccgcc gatttctctg gatctgacct ttcatctgct gcgtgaagtg      180

ctggaaatgg cacgtgcaga acagctggca cagcaggcgc acagcaaccg taaactgatg      240

gaaattatcg gaaattctct tgcaaaaaat gtattattcg gtggaaaagg taatgacaag      300

ctgtacggca gtgagggggc agatctgctt gatggtggag agggggatga tctcctgaaa      360

ggcggatatg gtaatgatat ttatcgttat ctgtcaggat atggtcatca tattattgat      420

gatgatgggg ggaaagagga taaactcagt ttggctgata ttgatttccg ggatgtggcc      480

ttcaagcgag aaggtaatga cctcatcatg tataaagctg aaggtaatgt tctttccatt      540

ggtcataaaa atggtattac attcaggaac tggtttgaaa aagagtcagg tgatatctct      600

aatcaccaga tagagcagat ttttgataaa agtggccgga taatcacacc tgattccctt      660

aaaaaggcac ttgagtatca acagcgtaat aataaggcaa gttatgtgta tgggaatgat      720

gcattagcct atggaagtca gggtgatctt aatccattaa ttaatgaaat cagcaaaatc      780

atttcagctg caggtagctt cgatgttaaa gaggaaagaa ctgcagcttc tttattgcag      840

ttgtccggta atgccagtga tttttcatat ggacggaact caataaccct gaccacatca      900

gcataa                                                                 906


<210>  306
<211>  301
<212>  PRT
<213>  Artificial

<220>
<223>  2xHCRF-HlyA1 fusion

<400>  306

Met Ser Glu Glu Pro Pro Ile Ser Leu Asp Leu Thr Phe His Leu Leu 
1               5                   10                  15      


Arg Glu Val Leu Glu Met Ala Arg Ala Glu Gln Leu Ala Gln Gln Ala 
            20                  25                  30          


His Ser Asn Arg Lys Leu Met Glu Ile Ile Ser Glu Glu Pro Pro Ile 
        35                  40                  45              


Ser Leu Asp Leu Thr Phe His Leu Leu Arg Glu Val Leu Glu Met Ala 
    50                  55                  60                  


Arg Ala Glu Gln Leu Ala Gln Gln Ala His Ser Asn Arg Lys Leu Met 
65                  70                  75                  80  


Glu Ile Ile Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys 
                85                  90                  95      


Gly Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly 
            100                 105                 110         


Gly Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr 
        115                 120                 125             


Arg Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly 
    130                 135                 140                 


Lys Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala 
145                 150                 155                 160 


Phe Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn 
                165                 170                 175     


Val Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe 
            180                 185                 190         


Glu Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe 
        195                 200                 205             


Asp Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu 
    210                 215                 220                 


Glu Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp 
225                 230                 235                 240 


Ala Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu 
                245                 250                 255     


Ile Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu 
            260                 265                 270         


Arg Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe 
        275                 280                 285             


Ser Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
    290                 295                 300     


<210>  307
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  307
catttaatta cctcttaacc agttaatg                                          28


<210>  308
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  308
agcgaagaac cgccg                                                        15


<210>  309
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  309
ggaaattctc ttgcaaaaaa tgtatta                                           27


<210>  310
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  310
gccctgaaaa tacaggtttt cgtggtggtg gtggtggtgc atttaattac ctcttaacca       60

gttaatg                                                                 67


<210>  311
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  311
tgtgatctgc cgcagac                                                      17


<210>  312
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  312
catttaatta cctcttaacc agttaatgaa aa                                     32


<210>  313
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  313
agaggtaatt aaatgggaaa ttctcttg                                          28


<210>  314
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  314
ctgcggcaga tcacaatcaa tatcagccaa actgagttta tc                          42


<210>  315
<211>  1383
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  315
atgggaaatt ctcttgcaaa aaatgtatta ttcggtggaa aaggtaatga caagctgtac       60

ggcagtgagg gggcagatct gcttgatggt ggagaggggg atgatctcct gaaaggcgga      120

tatggtaatg atatttatcg ttatctgtca ggatatggtc atcatattat tgatgatgat      180

ggggggaaag aggataaact cagtttggct gatattgatt gtgatctgcc gcagactcac      240

tctctgggtt ctcgtcgtac tctgatgctg ctggctcaga tgcgtcgtat ctctcttttc      300

tcctgcttga aggaccgtca tgactttgga tttccccagg aggagtttgg caaccagttc      360

caaaaggctg aaaccatccc tgtcctccat gagatgatcc agcagatctt caatctcttc      420

agcacaaagg actcatctgc tgcttgggat gagaccctcc tagacaaatt ctacactgaa      480

ctctaccagc agctgaatga cctggaagcc tgtgtgatac agggggtggg ggtgacagag      540

actcccctga tgaaggagga ctccattctg gctgtgagga aatacttcca aagaatcact      600

ctctatctga aagagaagaa atacagccct tgtgcctggg aggttgtcag agcagaaatc      660

atgagatctt tttctttgtc aacaaacttg caggaaagtt taagaagtaa ggaaattgat      720

ggccgtggaa attctcttgc aaaaaatgta ttattcggtg gaaaaggtaa tgacaagctg      780

tacggcagtg agggggcaga tctgcttgat ggtggagagg gggatgatct cctgaaaggc      840

ggatatggta atgatattta tcgttatctg tcaggatatg gtcatcatat tattgatgat      900

gatgggggga aagaggataa actcagtttg gctgatattg atttccggga tgtggccttc      960

aagcgagaag gtaatgacct catcatgtat aaagctgaag gtaatgttct ttccattggt     1020

cataaaaatg gtattacatt caggaactgg tttgaaaaag agtcaggtga tatctctaat     1080

caccagatag agcagatttt tgataaaagt ggccggataa tcacacctga ttcccttaaa     1140

aaggcacttg agtatcaaca gcgtaataat aaggcaagtt atgtgtatgg gaatgatgca     1200

ttagcctatg gaagtcaggg tgatcttaat ccattaatta atgaaatcag caaaatcatt     1260

tcagctgcag gtagcttcga tgttaaagag gaaagaactg cagcttcttt attgcagttg     1320

tccggtaatg ccagtgattt ttcatatgga cggaactcaa taaccctgac cacatcagca     1380

taa                                                                   1383


<210>  316
<211>  460
<212>  PRT
<213>  Artificial

<220>
<223>  RTX-IFNa2-HlyA1 fusion

<400>  316

Met Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
1               5                   10                  15      


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
            20                  25                  30          


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
        35                  40                  45              


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
    50                  55                  60                  


Asp Lys Leu Ser Leu Ala Asp Ile Asp Cys Asp Leu Pro Gln Thr His 
65                  70                  75                  80  


Ser Leu Gly Ser Arg Arg Thr Leu Met Leu Leu Ala Gln Met Arg Arg 
                85                  90                  95      


Ile Ser Leu Phe Ser Cys Leu Lys Asp Arg His Asp Phe Gly Phe Pro 
            100                 105                 110         


Gln Glu Glu Phe Gly Asn Gln Phe Gln Lys Ala Glu Thr Ile Pro Val 
        115                 120                 125             


Leu His Glu Met Ile Gln Gln Ile Phe Asn Leu Phe Ser Thr Lys Asp 
    130                 135                 140                 


Ser Ser Ala Ala Trp Asp Glu Thr Leu Leu Asp Lys Phe Tyr Thr Glu 
145                 150                 155                 160 


Leu Tyr Gln Gln Leu Asn Asp Leu Glu Ala Cys Val Ile Gln Gly Val 
                165                 170                 175     


Gly Val Thr Glu Thr Pro Leu Met Lys Glu Asp Ser Ile Leu Ala Val 
            180                 185                 190         


Arg Lys Tyr Phe Gln Arg Ile Thr Leu Tyr Leu Lys Glu Lys Lys Tyr 
        195                 200                 205             


Ser Pro Cys Ala Trp Glu Val Val Arg Ala Glu Ile Met Arg Ser Phe 
    210                 215                 220                 


Ser Leu Ser Thr Asn Leu Gln Glu Ser Leu Arg Ser Lys Glu Ile Asp 
225                 230                 235                 240 


Gly Arg Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly 
                245                 250                 255     


Asn Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly 
            260                 265                 270         


Glu Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg 
        275                 280                 285             


Tyr Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys 
    290                 295                 300                 


Glu Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe 
305                 310                 315                 320 


Lys Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val 
                325                 330                 335     


Leu Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu 
            340                 345                 350         


Lys Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp 
        355                 360                 365             


Lys Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu 
    370                 375                 380                 


Tyr Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala 
385                 390                 395                 400 


Leu Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile 
                405                 410                 415     


Ser Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg 
            420                 425                 430         


Thr Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser 
        435                 440                 445             


Tyr Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
    450                 455                 460 


<210>  317
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  317
agaggtaatt aaatgtgtga tctccctgag ac                                     32


<210>  318
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  318
gtgacggcca tcaatttcct tcctccttaa tctttc                                 36


<210>  319
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  319
agaggtaatt aaatgtgtga tctgcctcag ac                                     32


<210>  320
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  320
gtgacggcca tcaatttcct tactcttcaa tctttttt                               38


<210>  321
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  321
agaggtaatt aaatgtgtga tctgcctcag ac                                     32


<210>  322
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  322
gtgacggcca tcaatatcct tccttcttaa tccttttt                               38


<210>  323
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  323
agaggtaatt aaatgtgtga tctgcctcag ac                                     32


<210>  324
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  324
gtgacggcca tcaatatcct tccttcttaa tccttttt                               38


<210>  325
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  325
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgtgatct ccctgagacc      180

cacagcctgg ataacaggag gaccttgatg ctcctggcac aaatgagcag aatctctcct      240

tcctcctgtc tgatggacag acatgacttt ggatttcccc aggaggagtt tgatggcaac      300

cagttccaga aggctccagc catctctgtc ctccatgagc tgatccagca gatcttcaac      360

ctctttacca caaaagattc atctgctgct tgggatgagg acctcctaga caaattctgc      420

accgaactct accagcagct gaatgacttg gaagcctgtg tgatgcagga ggagagggtg      480

ggagaaactc ccctgatgaa tgcggactcc atcttggctg tgaagaaata cttccgaaga      540

atcactctct atctgacaga gaagaaatac agcccttgtg cctgggaggt tgtcagagca      600

gaaatcatga gatccctctc tttatcaaca aacttgcaag aaagattaag gaggaaggaa      660

attgatggcc gtcaccacca ccaccaccac ggaaattctc ttgcaaaaaa tgtattattc      720

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      780

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      840

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      900

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      960

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa     1020

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg     1080

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca     1140

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta     1200

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga     1260

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac     1320

tcaataaccc tgaccacatc agcataa                                         1347


<210>  326
<211>  1188
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  326
atgtgtgatc tccctgagac ccacagcctg gataacagga ggaccttgat gctcctggca       60

caaatgagca gaatctctcc ttcctcctgt ctgatggaca gacatgactt tggatttccc      120

caggaggagt ttgatggcaa ccagttccag aaggctccag ccatctctgt cctccatgag      180

ctgatccagc agatcttcaa cctctttacc acaaaagatt catctgctgc ttgggatgag      240

gacctcctag acaaattctg caccgaactc taccagcagc tgaatgactt ggaagcctgt      300

gtgatgcagg aggagagggt gggagaaact cccctgatga atgcggactc catcttggct      360

gtgaagaaat acttccgaag aatcactctc tatctgacag agaagaaata cagcccttgt      420

gcctgggagg ttgtcagagc agaaatcatg agatccctct ctttatcaac aaacttgcaa      480

gaaagattaa ggaggaagga aattgatggc cgtcaccacc accaccacca cggaaattct      540

cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg      600

gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata tggtaatgat      660

atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg ggggaaagag      720

gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg agaaggtaat      780

gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa aaatggtatt      840

acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca gatagagcag      900

atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc acttgagtat      960

caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc ctatggaagt     1020

cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc     1080

ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg taatgccagt     1140

gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataa                  1188


<210>  327
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  327
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgtgatct gcctcagact      180

cacagcctgg gtaacaggag ggccttgata ctcctggcac aaatgcgaag aatctctcct      240

ttctcctgcc tgaaggacag acatgacttt gaattccccc aggaggagtt tgatgataaa      300

cagttccaga aggctcaagc catctctgtc ctccatgaga tgatccagca gaccttcaac      360

ctcttcagca caaaggactc atctgctgct ttggatgaga cccttctaga tgaattctac      420

atcgaacttg accagcagct gaatgacctg gagtcctgtg tgatgcagga agtgggggtg      480

atagagtctc ccctgatgta cgaggactcc atcctggctg tgaggaaata cttccaaaga      540

atcactctat atctgacaga gaagaaatac agctcttgtg cctgggaggt tgtcagagca      600

gaaatcatga gatccttctc tttatcaatc aacttgcaaa aaagattgaa gagtaaggaa      660

attgatggcc gtcaccacca ccaccaccac ggaaattctc ttgcaaaaaa tgtattattc      720

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      780

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      840

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      900

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      960

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa     1020

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg     1080

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca     1140

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta     1200

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga     1260

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac     1320

tcaataaccc tgaccacatc agcataa                                         1347


<210>  328
<211>  1188
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  328
atgtgtgatc tgcctcagac tcacagcctg ggtaacagga gggccttgat actcctggca       60

caaatgcgaa gaatctctcc tttctcctgc ctgaaggaca gacatgactt tgaattcccc      120

caggaggagt ttgatgataa acagttccag aaggctcaag ccatctctgt cctccatgag      180

atgatccagc agaccttcaa cctcttcagc acaaaggact catctgctgc tttggatgag      240

acccttctag atgaattcta catcgaactt gaccagcagc tgaatgacct ggagtcctgt      300

gtgatgcagg aagtgggggt gatagagtct cccctgatgt acgaggactc catcctggct      360

gtgaggaaat acttccaaag aatcactcta tatctgacag agaagaaata cagctcttgt      420

gcctgggagg ttgtcagagc agaaatcatg agatccttct ctttatcaat caacttgcaa      480

aaaagattga agagtaagga aattgatggc cgtcaccacc accaccacca cggaaattct      540

cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg      600

gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata tggtaatgat      660

atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg ggggaaagag      720

gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg agaaggtaat      780

gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa aaatggtatt      840

acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca gatagagcag      900

atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc acttgagtat      960

caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc ctatggaagt     1020

cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc     1080

ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg taatgccagt     1140

gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataa                  1188


<210>  329
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  329
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgtgatct gcctcagact      180

cacagcctgg gtaataggag ggccttgata ctcctggcac aaatgggaag aatctctcat      240

ttctcctgcc tgaaggacag atatgatttc ggattccccc aggaggtgtt tgatggcaac      300

cagttccaga aggctcaagc catctctgcc ttccatgaga tgatccagca gaccttcaat      360

ctcttcagca caaaggattc atctgctgct tgggatgaga ccctcctaga caaattctac      420

attgaacttt tccagcaact gaatgaccta gaagcctgtg tgacacagga ggttggggtg      480

gaagagattg ccctgatgaa tgaggactcc atcctggctg tgaggaaata ctttcaaaga      540

atcactcttt atctgatggg gaagaaatac agcccttgtg cctgggaggt tgtcagagca      600

gaaatcatga gatccttctc tttttcaaca aacttgcaaa aaggattaag aaggaaggat      660

attgatggcc gtcaccacca ccaccaccac ggaaattctc ttgcaaaaaa tgtattattc      720

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      780

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      840

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      900

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      960

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa     1020

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg     1080

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca     1140

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta     1200

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga     1260

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac     1320

tcaataaccc tgaccacatc agcataa                                         1347


<210>  330
<211>  1188
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  330
atgtgtgatc tgcctcagac tcacagcctg ggtaatagga gggccttgat actcctggca       60

caaatgggaa gaatctctca tttctcctgc ctgaaggaca gatatgattt cggattcccc      120

caggaggtgt ttgatggcaa ccagttccag aaggctcaag ccatctctgc cttccatgag      180

atgatccagc agaccttcaa tctcttcagc acaaaggatt catctgctgc ttgggatgag      240

accctcctag acaaattcta cattgaactt ttccagcaac tgaatgacct agaagcctgt      300

gtgacacagg aggttggggt ggaagagatt gccctgatga atgaggactc catcctggct      360

gtgaggaaat actttcaaag aatcactctt tatctgatgg ggaagaaata cagcccttgt      420

gcctgggagg ttgtcagagc agaaatcatg agatccttct ctttttcaac aaacttgcaa      480

aaaggattaa gaaggaagga tattgatggc cgtcaccacc accaccacca cggaaattct      540

cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg      600

gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata tggtaatgat      660

atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg ggggaaagag      720

gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg agaaggtaat      780

gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa aaatggtatt      840

acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca gatagagcag      900

atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc acttgagtat      960

caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc ctatggaagt     1020

cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc     1080

ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg taatgccagt     1140

gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataa                  1188


<210>  331
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  331
tcccaaaact catgttggta aagtatcaga atttcatgga ggtaaaattg ataaacagtt       60

agcgaataaa atttttaaac aatatcacca cgagttaata actgaagtaa aaagaaagtc      120

agattttaat ttttcattaa ctggttaaga ggtaattaaa tgtgtgatct gcctcagacc      180

cacagcctgg gtaataggag ggccttgata ctcctggcac aaatgggaag aatctctcct      240

ttctcctgcc tgaaggacag acatgacttt ggattccccc aggaggagtt tgatggcaac      300

cagttccaga aggctcaagc catctctgtc ctccatgaga tgatccagca gaccttcaat      360

ctcttcagca caaaggactc atctgctact tgggaacaga gcctcctaga aaaattttcc      420

actgaactta accagcagct gaatgacctg gaagcctgcg tgatacagga ggttggggtg      480

gaagagactc ccctgatgaa tgtggactcc atcctggctg tgaagaaata cttccaaaga      540

atcactcttt atctgacaga gaagaaatac agcccttgtg cctgggaggt tgtcagagca      600

gaaatcatga gatccttctc tttatcaaaa atttttcaag aaagattaag gaggaaggaa      660

attgatggcc gtcaccacca ccaccaccac ggaaattctc ttgcaaaaaa tgtattattc      720

ggtggaaaag gtaatgacaa gctgtacggc agtgaggggg cagatctgct tgatggtgga      780

gagggggatg atctcctgaa aggcggatat ggtaatgata tttatcgtta tctgtcagga      840

tatggtcatc atattattga tgatgatggg gggaaagagg ataaactcag tttggctgat      900

attgatttcc gggatgtggc cttcaagcga gaaggtaatg acctcatcat gtataaagct      960

gaaggtaatg ttctttccat tggtcataaa aatggtatta cattcaggaa ctggtttgaa     1020

aaagagtcag gtgatatctc taatcaccag atagagcaga tttttgataa aagtggccgg     1080

ataatcacac ctgattccct taaaaaggca cttgagtatc aacagcgtaa taataaggca     1140

agttatgtgt atgggaatga tgcattagcc tatggaagtc agggtgatct taatccatta     1200

attaatgaaa tcagcaaaat catttcagct gcaggtagct tcgatgttaa agaggaaaga     1260

actgcagctt ctttattgca gttgtccggt aatgccagtg atttttcata tggacggaac     1320

tcaataaccc tgaccacatc agcataa                                         1347


<210>  332
<211>  1188
<212>  DNA
<213>  Artificial

<220>
<223>  Expression construct

<400>  332
atgtgtgatc tgcctcagac ccacagcctg ggtaatagga gggccttgat actcctggca       60

caaatgggaa gaatctctcc tttctcctgc ctgaaggaca gacatgactt tggattcccc      120

caggaggagt ttgatggcaa ccagttccag aaggctcaag ccatctctgt cctccatgag      180

atgatccagc agaccttcaa tctcttcagc acaaaggact catctgctac ttgggaacag      240

agcctcctag aaaaattttc cactgaactt aaccagcagc tgaatgacct ggaagcctgc      300

gtgatacagg aggttggggt ggaagagact cccctgatga atgtggactc catcctggct      360

gtgaagaaat acttccaaag aatcactctt tatctgacag agaagaaata cagcccttgt      420

gcctgggagg ttgtcagagc agaaatcatg agatccttct ctttatcaaa aatttttcaa      480

gaaagattaa ggaggaagga aattgatggc cgtcaccacc accaccacca cggaaattct      540

cttgcaaaaa atgtattatt cggtggaaaa ggtaatgaca agctgtacgg cagtgagggg      600

gcagatctgc ttgatggtgg agagggggat gatctcctga aaggcggata tggtaatgat      660

atttatcgtt atctgtcagg atatggtcat catattattg atgatgatgg ggggaaagag      720

gataaactca gtttggctga tattgatttc cgggatgtgg ccttcaagcg agaaggtaat      780

gacctcatca tgtataaagc tgaaggtaat gttctttcca ttggtcataa aaatggtatt      840

acattcagga actggtttga aaaagagtca ggtgatatct ctaatcacca gatagagcag      900

atttttgata aaagtggccg gataatcaca cctgattccc ttaaaaaggc acttgagtat      960

caacagcgta ataataaggc aagttatgtg tatgggaatg atgcattagc ctatggaagt     1020

cagggtgatc ttaatccatt aattaatgaa atcagcaaaa tcatttcagc tgcaggtagc     1080

ttcgatgtta aagaggaaag aactgcagct tctttattgc agttgtccgg taatgccagt     1140

gatttttcat atggacggaa ctcaataacc ctgaccacat cagcataa                  1188


<210>  333
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  IFNA1-HlyA1 fusion

<400>  333

Met Cys Asp Leu Pro Glu Thr His Ser Leu Asp Asn Arg Arg Thr Leu 
1               5                   10                  15      


Met Leu Leu Ala Gln Met Ser Arg Ile Ser Pro Ser Ser Cys Leu Met 
            20                  25                  30          


Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln 
        35                  40                  45              


Phe Gln Lys Ala Pro Ala Ile Ser Val Leu His Glu Leu Ile Gln Gln 
    50                  55                  60                  


Ile Phe Asn Leu Phe Thr Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu 
65                  70                  75                  80  


Asp Leu Leu Asp Lys Phe Cys Thr Glu Leu Tyr Gln Gln Leu Asn Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Met Gln Glu Glu Arg Val Gly Glu Thr Pro Leu 
            100                 105                 110         


Met Asn Ala Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Arg Arg Ile 
        115                 120                 125             


Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val 
    130                 135                 140                 


Val Arg Ala Glu Ile Met Arg Ser Leu Ser Leu Ser Thr Asn Leu Gln 
145                 150                 155                 160 


Glu Arg Leu Arg Arg Lys Glu Ile Asp Gly Arg His His His His His 
                165                 170                 175     


His Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
            180                 185                 190         


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
        195                 200                 205             


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
    210                 215                 220                 


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
225                 230                 235                 240 


Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys 
                245                 250                 255     


Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu 
            260                 265                 270         


Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys 
        275                 280                 285             


Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys 
    290                 295                 300                 


Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr 
305                 310                 315                 320 


Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu 
                325                 330                 335     


Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser 
            340                 345                 350         


Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr 
        355                 360                 365             


Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr 
    370                 375                 380                 


Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
385                 390                 395 


<210>  334
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  IFNA8-HlyA1 fusion

<400>  334

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu 
1               5                   10                  15      


Ile Leu Leu Ala Gln Met Arg Arg Ile Ser Pro Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg His Asp Phe Glu Phe Pro Gln Glu Glu Phe Asp Asp Lys Gln 
        35                  40                  45              


Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln 
    50                  55                  60                  


Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Leu Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Asp Glu Phe Tyr Ile Glu Leu Asp Gln Gln Leu Asn Asp 
                85                  90                  95      


Leu Glu Ser Cys Val Met Gln Glu Val Gly Val Ile Glu Ser Pro Leu 
            100                 105                 110         


Met Tyr Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile 
        115                 120                 125             


Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Ser Cys Ala Trp Glu Val 
    130                 135                 140                 


Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Ile Asn Leu Gln 
145                 150                 155                 160 


Lys Arg Leu Lys Ser Lys Glu Ile Asp Gly Arg His His His His His 
                165                 170                 175     


His Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
            180                 185                 190         


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
        195                 200                 205             


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
    210                 215                 220                 


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
225                 230                 235                 240 


Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys 
                245                 250                 255     


Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu 
            260                 265                 270         


Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys 
        275                 280                 285             


Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys 
    290                 295                 300                 


Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr 
305                 310                 315                 320 


Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu 
                325                 330                 335     


Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser 
            340                 345                 350         


Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr 
        355                 360                 365             


Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr 
    370                 375                 380                 


Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
385                 390                 395 


<210>  335
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  IFNA16-HlyA1 fusion

<400>  335

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu 
1               5                   10                  15      


Ile Leu Leu Ala Gln Met Gly Arg Ile Ser His Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg Tyr Asp Phe Gly Phe Pro Gln Glu Val Phe Asp Gly Asn Gln 
        35                  40                  45              


Phe Gln Lys Ala Gln Ala Ile Ser Ala Phe His Glu Met Ile Gln Gln 
    50                  55                  60                  


Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Ala Trp Asp Glu 
65                  70                  75                  80  


Thr Leu Leu Asp Lys Phe Tyr Ile Glu Leu Phe Gln Gln Leu Asn Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Thr Gln Glu Val Gly Val Glu Glu Ile Ala Leu 
            100                 105                 110         


Met Asn Glu Asp Ser Ile Leu Ala Val Arg Lys Tyr Phe Gln Arg Ile 
        115                 120                 125             


Thr Leu Tyr Leu Met Gly Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val 
    130                 135                 140                 


Val Arg Ala Glu Ile Met Arg Ser Phe Ser Phe Ser Thr Asn Leu Gln 
145                 150                 155                 160 


Lys Gly Leu Arg Arg Lys Asp Ile Asp Gly Arg His His His His His 
                165                 170                 175     


His Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
            180                 185                 190         


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
        195                 200                 205             


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
    210                 215                 220                 


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
225                 230                 235                 240 


Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys 
                245                 250                 255     


Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu 
            260                 265                 270         


Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys 
        275                 280                 285             


Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys 
    290                 295                 300                 


Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr 
305                 310                 315                 320 


Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu 
                325                 330                 335     


Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser 
            340                 345                 350         


Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr 
        355                 360                 365             


Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr 
    370                 375                 380                 


Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
385                 390                 395 


<210>  336
<211>  395
<212>  PRT
<213>  Artificial

<220>
<223>  IFNA21-HlyA1 fusion

<400>  336

Met Cys Asp Leu Pro Gln Thr His Ser Leu Gly Asn Arg Arg Ala Leu 
1               5                   10                  15      


Ile Leu Leu Ala Gln Met Gly Arg Ile Ser Pro Phe Ser Cys Leu Lys 
            20                  25                  30          


Asp Arg His Asp Phe Gly Phe Pro Gln Glu Glu Phe Asp Gly Asn Gln 
        35                  40                  45              


Phe Gln Lys Ala Gln Ala Ile Ser Val Leu His Glu Met Ile Gln Gln 
    50                  55                  60                  


Thr Phe Asn Leu Phe Ser Thr Lys Asp Ser Ser Ala Thr Trp Glu Gln 
65                  70                  75                  80  


Ser Leu Leu Glu Lys Phe Ser Thr Glu Leu Asn Gln Gln Leu Asn Asp 
                85                  90                  95      


Leu Glu Ala Cys Val Ile Gln Glu Val Gly Val Glu Glu Thr Pro Leu 
            100                 105                 110         


Met Asn Val Asp Ser Ile Leu Ala Val Lys Lys Tyr Phe Gln Arg Ile 
        115                 120                 125             


Thr Leu Tyr Leu Thr Glu Lys Lys Tyr Ser Pro Cys Ala Trp Glu Val 
    130                 135                 140                 


Val Arg Ala Glu Ile Met Arg Ser Phe Ser Leu Ser Lys Ile Phe Gln 
145                 150                 155                 160 


Glu Arg Leu Arg Arg Lys Glu Ile Asp Gly Arg His His His His His 
                165                 170                 175     


His Gly Asn Ser Leu Ala Lys Asn Val Leu Phe Gly Gly Lys Gly Asn 
            180                 185                 190         


Asp Lys Leu Tyr Gly Ser Glu Gly Ala Asp Leu Leu Asp Gly Gly Glu 
        195                 200                 205             


Gly Asp Asp Leu Leu Lys Gly Gly Tyr Gly Asn Asp Ile Tyr Arg Tyr 
    210                 215                 220                 


Leu Ser Gly Tyr Gly His His Ile Ile Asp Asp Asp Gly Gly Lys Glu 
225                 230                 235                 240 


Asp Lys Leu Ser Leu Ala Asp Ile Asp Phe Arg Asp Val Ala Phe Lys 
                245                 250                 255     


Arg Glu Gly Asn Asp Leu Ile Met Tyr Lys Ala Glu Gly Asn Val Leu 
            260                 265                 270         


Ser Ile Gly His Lys Asn Gly Ile Thr Phe Arg Asn Trp Phe Glu Lys 
        275                 280                 285             


Glu Ser Gly Asp Ile Ser Asn His Gln Ile Glu Gln Ile Phe Asp Lys 
    290                 295                 300                 


Ser Gly Arg Ile Ile Thr Pro Asp Ser Leu Lys Lys Ala Leu Glu Tyr 
305                 310                 315                 320 


Gln Gln Arg Asn Asn Lys Ala Ser Tyr Val Tyr Gly Asn Asp Ala Leu 
                325                 330                 335     


Ala Tyr Gly Ser Gln Gly Asp Leu Asn Pro Leu Ile Asn Glu Ile Ser 
            340                 345                 350         


Lys Ile Ile Ser Ala Ala Gly Ser Phe Asp Val Lys Glu Glu Arg Thr 
        355                 360                 365             


Ala Ala Ser Leu Leu Gln Leu Ser Gly Asn Ala Ser Asp Phe Ser Tyr 
    370                 375                 380                 


Gly Arg Asn Ser Ile Thr Leu Thr Thr Ser Ala 
385                 390                 395 


<210>  337
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  337
atgacaacaa taaccactgc                                                   20


<210>  338
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Oligonucleotide primer

<400>  338
gaggtaatta aatgacaaca ataac                                             25


